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Daniel M. Goldenholz, M.D.,Ph.D.

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Biography
University of Wisconsin-Madison, Madison, WIB.S.05/2000Electrical and computer engineering
Boston University, Boston, MAMD, PhD05/2008Medicine (MD) and Biomedical Engineering (PhD)
Mass General Hospital, Charleston, MAPostdoc fellowship06/2009Radiology
Alameda County Medical Center, Oakland, CAInternship06/2010Internal medicine
University of California-Davis, Sacramento, CAResidency06/2013Neurology
National Institutes of Health, Bethesda, MDClinical fellowship06/2014Epilepsy
National Institutes of Health, Bethesda, MDClinical fellowship06/2015Clinical Neurophysiology
National Institutes of Health, Bethesda, MDClinical fellowship05/2017Advanced Epilepsy
Duke University, Durham, NCMHsc05/2017Health Science

Overview
Key research interests in data science applied to epilepsy:
1. Natural seizure patterns - this includes understanding the natural fluctuations of seizure counts, seizure clustering, and seizure forecasting.
2. Biosensor dynamics - here we are using biosensors such as ECG and pulse oximetry to understand hidden markers of risk for sudden cardiac death and/or sudden unexpected death in epilepsy (SUDEP).
3. Clinical trial improvements - developing techniques for more rapid, more efficient yet less expensive clinical trials in epilepsy that will accelerate bringing novel treatments to this disease.

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Casassa C, Rathbun Levit E, Goldenholz DM. Opinion and Special Articles: Self-management in epilepsy: Web-based seizure tracking applications. Neurology. 2018 Nov 20; 91(21):e2027-e2030. PMID: 30455263.
    View in: PubMed
  2. Goldenholz DM, Goldenholz SR, Krishnamurthy KB, Halamka J, Karp B, Tyburski M, Wendler D, Moss R, Preston KL, Theodore W. Using mobile location data in biomedical research while preserving privacy. J Am Med Inform Assoc. 2018 Oct 01; 25(10):1402-1406. PMID: 29889279.
    View in: PubMed
  3. Karoly PJ, Goldenholz DM, Freestone DR, Moss RE, Grayden DB, Theodore WH, Cook MJ. Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study. Lancet Neurol. 2018 Nov; 17(11):977-985. PMID: 30219655.
    View in: PubMed
  4. Ferastraoaru V, Goldenholz DM, Chiang S, Moss R, Theodore WH, Haut SR. Characteristics of large patient-reported outcomes: Where can one million seizures get us? Epilepsia Open. 2018 Sep; 3(3):364-373. PMID: 30187007.
    View in: PubMed
  5. Goldenholz DM, Rakesh K, Kapur K, Gaínza-Lein M, Hodgeman R, Moss R, Theodore WH, Loddenkemper T. Different as night and day: Patterns of isolated seizures, clusters, and status epilepticus. Epilepsia. 2018 05; 59(5):e73-e77. PMID: 29683201.
    View in: PubMed
  6. Chiang S, Vannucci M, Goldenholz DM, Moss R, Stern JM. Epilepsy as a dynamic disease: A Bayesian model for differentiating seizure risk from natural variability. Epilepsia Open. 2018 Jun; 3(2):236-246. PMID: 29881802.
    View in: PubMed
  7. Karoly P, Goldenholz DM, Cook M. Are the days of counting seizures numbered? Curr Opin Neurol. 2018 04; 31(2):162-168. PMID: 29369115.
    View in: PubMed
  8. Goldenholz DM, Moss R, Jost DA, Crone NE, Krauss G, Picard R, Caborni C, Cavazos JE, Hixson J, Loddenkemper T, Salazar TD, Lubbers L, Harte-Hargrove LC, Whittemore V, Duun-Henriksen J, Dolan E, Kasturia N, Oberemk M, Cook MJ, Lehmkuhle M, Sperling MR, Shafer PO. Common data elements for epilepsy mobile health systems. Epilepsia. 2018 05; 59(5):1020-1026. PMID: 29604050.
    View in: PubMed
  9. Hodges S, Goldenholz DM, Sato S, Theodore WH, Inati S. Postoperative EEG association with seizure recurrence: Analysis of the NIH epilepsy surgery database. Epilepsia Open. 2018 03; 3(1):109-112. PMID: 29588996.
    View in: PubMed
  10. Goldenholz, D. M., Goldenholz, S. R., Moss, R., French, J., Lowenstein, D., Kuzniecky, R., Haut, S., Cristofaro, S., Detyniecki, K., Hixson, J., Karoly, P., Cook, M., Strashny, A. and Theodore, W. H. Is seizure frequency variance a predictable quantity?. Ann Clin Transl Neurol. 2018.
  11. Goldenholz DM, Goldenholz SR, Moss R, French J, Lowenstein D, Kuzniecky R, Haut S, Cristofaro S, Detyniecki K, Hixson J, Karoly P, Cook M, Strashny A, Theodore WH. Is seizure frequency variance a predictable quantity? Ann Clin Transl Neurol. 2018 02; 5(2):201-207. PMID: 29468180.
    View in: PubMed
  12. Hodges S, Goldenholz DM, Sato S, Theodore WH, Inati S. Post-operative EEG as a tool to predict seizure recurrence: analysis of the NIH epilepsy surgery database. Epilepsia Open. 2018.
  13. Goldenholz DM. Virtual Special Edition: Does Natural Variability in Seizure Frequency Matter?. Seizure. 2018; 53.
  14. Goldenholz DM, Strashny A, Cook M, Moss R, Theodore WH. A multi-dataset time-reversal approach to clinical trial placebo response and the relationship to natural variability in epilepsy. Seizure. 2017 Dec; 53:31-36. PMID: 29102709.
    View in: PubMed
  15. Goldenholz DM, Goldenholz SR, Moss R, French J, Lowenstein D, Kuzniecky R, Haut S, Cristofaro S, Detyniecki K, Hixson J, Karoly P, Cook M, Strashny A, Theodore WH, Pieper C. Does accounting for seizure frequency variability increase clinical trial power? Epilepsy Res. 2017 11; 137:145-151. PMID: 28781216.
    View in: PubMed
  16. Goldenholz DM, Tharayil J, Moss R, Myers E, Theodore WH. Monte Carlo simulations of randomized clinical trials in epilepsy. Ann Clin Transl Neurol. 2017 08; 4(8):544-552. PMID: 28812044.
    View in: PubMed
  17. Tharayil JJ, Chiang S, Moss R, Stern JM, Theodore WH, Goldenholz DM. A big data approach to the development of mixed-effects models for seizure count data. Epilepsia. 2017 05; 58(5):835-844. PMID: 28369781.
    View in: PubMed
  18. Goldenholz DM, Tharayil JJ, Kuzniecky R, Karoly P, Theodore WH, Cook MJ. Simulating Clinical Trials With and Without Intracranial EEG Data. Epilepsia Open. 2017 Jun; 2(2):156-161. PMID: 28758158.
    View in: PubMed
  19. Goldenholz DM, Kuhn A, Austermuehle A, Bachler M, Mayer C, Wassertheurer S, Inati SK, Theodore WH. Long-term monitoring of cardiorespiratory patterns in drug-resistant epilepsy. Epilepsia. 2017 01; 58(1):77-84. PMID: 27864903.
    View in: PubMed
  20. Goldenholz DM, Jow A, Khan OI, Bagic A, Sato S, Auh S, Kufta C, Inati S, Theodore WH. Preoperative prediction of temporal lobe epilepsy surgery outcome. Epilepsy Res. 2016 11; 127:331-338. PMID: 27701046.
    View in: PubMed
  21. Goldenholz DM, Goldenholz SR. Response to placebo in clinical epilepsy trials--Old ideas and new insights. Epilepsy Res. 2016 May; 122:15-25. PMID: 26921852.
    View in: PubMed
  22. Goldenholz DM, Moss R, Scott J, Auh S, Theodore WH. Confusing placebo effect with natural history in epilepsy: A big data approach. Ann Neurol. 2015 Sep; 78(3):329-36. PMID: 26150090.
    View in: PubMed
  23. Goldenholz DM. Right brain: how to treat the untreatable. Neurology. 2013 Oct 15; 81(16):1472-3. PMID: 24127191.
    View in: PubMed
  24. Goldenholz DM, Mehra N, Dahlin B, Cohen SH, Wheelock VL. Teaching neuroimages: fungus in the brain: coccidioidomycosis meningoencephalitis. Neurology. 2013 Feb 19; 80(8):e82. PMID: 23420900.
    View in: PubMed
  25. Goldenholz, DM. Neurology. Media and Book Reviews: Netter's Anatomy Atlas for iPad; Atlas of Human Anatomy (Netter Basic Science) (Kindle Edition With Audio/Video); Atlas of Human Anatomy (Etextbook); Netter's Atlas of Human Anatomy. 2012; 79(18).
  26. Goldenholz, D. Neurology. Media and Book Reviews: Reading EEGs: A Practical Approach. 2012; 79(6).
  27. Goldenholz DM, Wong VS, Bateman LM, Apperson M, Oskarsson B, Akhtar S, Wheelock V. Treatment of ?-aminobutyric acid B receptor-antibody autoimmune encephalitis with oral corticosteroids. Arch Neurol. 2012 Aug; 69(8):1061-3. PMID: 22507884.
    View in: PubMed
  28. Goldenholz DM, Seyal M, Bateman LM, Gotman J, Andrade-Valenca L, Zelmann R, Dubeau F. Interictal scalp fast oscillations as a marker of the seizure onset zone. Neurology. 2012 Jan 17; 78(3):224-5; author reply 225. PMID: 22249499; PMCID: PMC3754949.
  29. Goldenholz DM. Media and book reviews: Introduction: taking the digital plunge. Neurology. 2011 Dec 13; 77(24):e141-2. PMID: 22170947.
    View in: PubMed
  30. Goldenholz DM. Media and book reviews: Medications: how can we know them all? Neurology. 2011 Dec 13; 77(24):e143-4. PMID: 22170948.
    View in: PubMed
  31. Goldenholz, DM. Portable Digital Direct Ophthalmoscope. 2011.
  32. Cooper RJ, Gagnon L, Goldenholz DM, Boas DA, Greve DN. The utility of near-infrared spectroscopy in the regression of low-frequency physiological noise from functional magnetic resonance imaging data. Neuroimage. 2012 Feb 15; 59(4):3128-38. PMID: 22119653; PMCID: PMC3288700.
  33. Gagnon L, Perdue K, Greve DN, Goldenholz D, Kaskhedikar G, Boas DA. Improved recovery of the hemodynamic response in diffuse optical imaging using short optode separations and state-space modeling. Neuroimage. 2011 Jun 01; 56(3):1362-71. PMID: 21385616; PMCID: PMC3085546.
  34. Goldenholz DM, Ahlfors SP, Hämäläinen MS, Sharon D, Ishitobi M, Vaina LM, Stufflebeam SM. Mapping the signal-to-noise-ratios of cortical sources in magnetoencephalography and electroencephalography. Hum Brain Mapp. 2009 Apr; 30(4):1077-86. PMID: 18465745; PMCID: PMC2882168.
  35. Goldenholz, DM. Spatiotemporal techniques in multimodal imaging for brain mapping and epilepsy. 2006.
  36. Goldenholz, D. Liquid computing: A real effect. 2002.
  37. Harel T, Kornfeld J, Felsen B, Haham Y, Goldenholz D. BLOOD FLOW CONTROLLER. 2001.
  38. Felsen B, Darvish N, Goldenholz D . INHIBITION OF ACTION POTENTIALS. 2001.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.