Harvard Catalyst Profiles

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Kip Connor, Ph.D.

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Mentoring
Available: 10/16/18, Expires: 10/30/20

Retinal detachment and subsequent neurodegeneration of the retina continues to be a leading cause of visual impairment resulting from ocular trauma. Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD). However, the underlying processes that facilitate this have remained elusive. This project aims to identify the initiating factors involved in photoreceptor cell death (retinal degeneration) in response to traumatic retinal detachment. This study is innovative in that it will begin to define the initiating factors involved in retinal neurodegeneration, a common cause of vision loss. When photoreceptor degeneration occurs it tends to correlate to a rise in immune activity. One possibility is that the immune system is mounting a response against the photoreceptors in the damaged retina to specifically target their removal. This can severely impact visual acuity, understanding the mechanism by which the immune system facilitates photoreceptor apoptosis in retinal detachment remains unresolved and it could be of significant therapeutic value to dampen its effects. The retina is specialized neural tissue and is commonly referred to as the “window into the brain”. Findings in this proposal will likely encompass similar mechanisms found in other neurodegenerations resulting from traumatic brain injury.

The PI and a senior fellow in the laboratory will oversee the student working on this project. They will learn how to effectively employ the mouse model of retinal detachment and utilize key transgenic animals in order to define immune mediators of retinal degeneration. Additionally, if time allows, key pharmaceutical therapeutics will be identified and utilized in vivo in order to temper neurodegeneration.

Characterizing the role of the complement system in vascular regression in a mouse model of retinopathy
Summer, 06/17/13 - 08/16/13

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY029269 (CONNOR, KIP M) Apr 1, 2019 - Mar 31, 2023
    NIH/NEI
    Sex dependent regulation of retinal degeneration
    Role: Principal Investigator
  2. R01EY027303 (CONNOR, KIP M) May 1, 2018 - Apr 30, 2021
    NIH/NEI
    The Alternative Complement System Facilitates Photoreceptor Degeneration in Retinal Detachment.
    Role: Principal Investigator
  3. R01EY022084 (CONNOR, KIP M) Apr 1, 2012 - Mar 31, 2016
    NIH/NEI
    Complement Mediated Neovascularization in Retinopathy
    Role: Principal Investigator
  4. F32EY017789 (CONNOR, KIP M) Feb 13, 2007 - Feb 12, 2009
    NIH/NEI
    Dietary Control Angiogenesis in Retinopathy
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Uchi SH, Yanai R, Kobayashi M, Hatano M, Kobayashi Y, Yamashiro C, Nagai T, Tokuda K, Connor KM, Sonoda KH, Kimura K. Correction: Dendritic cells mediate the anti-inflammatory action of omega-3 long-chain polyunsaturated fatty acids in experimental autoimmune uveitis. PLoS One. 2020; 15(3):e0231277. PMID: 32218588.
    Citations:    
  2. Hughes S, Gumas J, Lee R, Rumano M, Berger N, Gautam AK, Sfyroera G, Chan AL, Gnanaguru G, Connor KM, Kim BJ, Dunaief JL, Ricklin D, Hajishengallis G, Yancopoulou D, Reis ES, Mastellos DC, Lambris JD. Prolonged intraocular residence and retinal tissue distribution of a fourth-generation compstatin-based C3 inhibitor in non-human primates. Clin Immunol. 2020 May; 214:108391. PMID: 32229292.
    Citations:    
  3. Uchi SH, Yanai R, Kobayashi M, Hatano M, Kobayashi Y, Yamashiro C, Nagai T, Tokuda K, Connor KM, Sonoda KH, Kimura K. Dendritic cells mediate the anti-inflammatory action of omega-3 long-chain polyunsaturated fatty acids in experimental autoimmune uveitis. PLoS One. 2019; 14(7):e0219405. PMID: 31335861.
    Citations:    
  4. Park DH, Connor KM, Lambris JD. The Challenges and Promise of Complement Therapeutics for Ocular Diseases. Front Immunol. 2019; 10:1007. PMID: 31156618.
    Citations:    
  5. Okunuki Y, Mukai R, Nakao T, Tabor SJ, Butovsky O, Dana R, Ksander BR, Connor KM. Retinal microglia initiate neuroinflammation in ocular autoimmunity. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):9989-9998. PMID: 31023885.
    Citations:    
  6. Mukai R, Park DH, Okunuki Y, Hasegawa E, Klokman G, Kim CB, Krishnan A, Gregory-Ksander M, Husain D, Miller JW, Connor KM. Mouse model of ocular hypertension with retinal ganglion cell degeneration. PLoS One. 2019; 14(1):e0208713. PMID: 30640920.
    Citations:    Fields:    
  7. Pearsall EA, Connor KM. Atypical Protein Kinase C: Breaking Down Barriers in Ocular Disease? Am J Pathol. 2018 10; 188(10):2142-2146. PMID: 30220553.
    Citations:    Fields:    
  8. Inafuku S, Klokman G, Connor KM. The Alternative Complement System Mediates Cell Death in Retinal Ischemia Reperfusion Injury. Front Mol Neurosci. 2018; 11:278. PMID: 30174588.
    Citations:    
  9. Okunuki Y, Mukai R, Pearsall EA, Klokman G, Husain D, Park DH, Korobkina E, Weiner HL, Butovsky O, Ksander BR, Miller JW, Connor KM. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6264-E6273. PMID: 29915052.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Yanai R, Chen S, Uchi SH, Nanri T, Connor KM, Kimura K. Attenuation of choroidal neovascularization by dietary intake of ?-3 long-chain polyunsaturated fatty acids and lutein in mice. PLoS One. 2018; 13(4):e0196037. PMID: 29694386.
    Citations:    Fields:    Translation:Animals
  11. Mukai R, Okunuki Y, Husain D, Kim CB, Lambris JD, Connor KM. The Complement System Is Critical in Maintaining Retinal Integrity during Aging. Front Aging Neurosci. 2018; 10:15. PMID: 29497373.
    Citations:    
  12. Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM. Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization. Proc Natl Acad Sci U S A. 2017 09 05; 114(36):E7545-E7553. PMID: 28827330.
    Citations:    Fields:    Translation:AnimalsCells
  13. Kim CB, D'Amore PA, Connor KM. Revisiting the mouse model of oxygen-induced retinopathy. Eye Brain. 2016; 8:67-79. PMID: 27499653.
    Citations: 6     
  14. Kim C, Smith KE, Castillejos A, Diaz-Aguilar D, Saint-Geniez M, Connor KM. The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy. FASEB J. 2016 Mar; 30(3):1300-5. PMID: 26631482.
    Citations: 5     Fields:    Translation:Animals
  15. Shoda H, Yanai R, Yoshimura T, Nagai T, Kimura K, Sobrin L, Connor KM, Sakoda Y, Tamada K, Ikeda T, Sonoda KH. Dietary Omega-3 Fatty Acids Suppress Experimental Autoimmune Uveitis in Association with Inhibition of Th1 and Th17 Cell Function. PLoS One. 2015; 10(9):e0138241. PMID: 26393358.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  16. Sweigard JH, Matsumoto H, Smith KE, Kim LA, Paschalis EI, Okonuki Y, Castillejos A, Kataoka K, Hasegawa E, Yanai R, Husain D, Lambris JD, Vavvas D, Miller JW, Connor KM. Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury. Sci Transl Med. 2015 Jul 22; 7(297):297ra116. PMID: 26203084.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM, Panjwani N. Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response. PLoS One. 2015; 10(6):e0130772. PMID: 26126176.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG. Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death. Cell Death Dis. 2015 Apr 23; 6:e1731. PMID: 25906154.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  19. Mulki L, Sweigard JH, Connor KM. Assessing leukocyte-endothelial interactions under flow conditions in an ex vivo autoperfused microflow chamber assay. J Vis Exp. 2014 Dec 30; (94). PMID: 25590688.
    Citations:    Fields:    Translation:AnimalsCells
  20. Hasegawa E, Sweigard H, Husain D, Olivares AM, Chang B, Smith KE, Birsner AE, D'Amato RJ, Michaud NA, Han Y, Vavvas DG, Miller JW, Haider NB, Connor KM. Characterization of a spontaneous retinal neovascular mouse model. PLoS One. 2014; 9(9):e106507. PMID: 25188381.
    Citations: 8     Fields:    Translation:Animals
  21. Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM. Cytochrome P450-generated metabolites derived from ?-3 fatty acids attenuate neovascularization. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9603-8. PMID: 24979774.
    Citations: 13     Fields:    Translation:Animals
  22. Matsumoto H, Murakami Y, Kataoka K, Lin H, Connor KM, Miller JW, Zhou D, Avruch J, Vavvas DG. Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment. Cell Death Dis. 2014 May 29; 5:e1269. PMID: 24874741.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Matsumoto H, Kataoka K, Tsoka P, Connor KM, Miller JW, Vavvas DG. Strain difference in photoreceptor cell death after retinal detachment in mice. Invest Ophthalmol Vis Sci. 2014 May 22; 55(7):4165-74. PMID: 24854853.
    Citations: 15     Fields:    Translation:AnimalsCells
  24. Sweigard JH, Yanai R, Gaissert P, Saint-Geniez M, Kataoka K, Thanos A, Stahl GL, Lambris JD, Connor KM. The alternative complement pathway regulates pathological angiogenesis in the retina. FASEB J. 2014 Jul; 28(7):3171-82. PMID: 24668752.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  25. Takeuchi K, Yanai R, Kumase F, Morizane Y, Suzuki J, Kayama M, Brodowska K, Nakazawa M, Miller JW, Connor KM, Vavvas DG. EGF-like-domain-7 is required for VEGF-induced Akt/ERK activation and vascular tube formation in an ex vivo angiogenesis assay. PLoS One. 2014; 9(3):e91849. PMID: 24647208.
    Citations: 7     Fields:    Translation:AnimalsCells
  26. Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ. Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment. J Clin Invest. 2014 Jan; 124(1):425-36. PMID: 24355922.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  27. Murakami Y, Matsumoto H, Roh M, Giani A, Kataoka K, Morizane Y, Kayama M, Thanos A, Nakatake S, Notomi S, Hisatomi T, Ikeda Y, Ishibashi T, Connor KM, Miller JW, Vavvas DG. Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration. Cell Death Differ. 2014 Feb; 21(2):270-7. PMID: 23954861.
    Citations: 50     Fields:    Translation:AnimalsCells
  28. Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a regulates normal and pathological angiogenesis in the retina. Am J Pathol. 2013 Jan; 182(1):255-65. PMID: 23141926.
    Citations: 16     Fields:    Translation:HumansAnimals
  29. Yanai R, Thanos A, Connor KM. Complement involvement in neovascular ocular diseases. Adv Exp Med Biol. 2012; 946:161-83. PMID: 21948368.
    Citations: 16     Fields:    Translation:Humans
  30. Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. PMID: 21307302.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  31. Stahl A, Sapieha P, Connor KM, Sangiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. PMID: 20634487.
    Citations: 33     Fields:    Translation:Animals
  32. Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, Hua J, Löfqvist C, Hellström A, Smith LE. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. PMID: 20484600.
    Citations: 154     Fields:    Translation:Animals
  33. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. PMID: 19816419.
    Citations: 178     Fields:    Translation:Animals
  34. Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8. PMID: 19242469.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  35. Stahl A, Connor KM, Sapieha P, Willett KL, Krah NM, Dennison RJ, Chen J, Guerin KI, Smith LE. Computer-aided quantification of retinal neovascularization. Angiogenesis. 2009; 12(3):297-301. PMID: 19757106.
    Citations: 59     Fields:    Translation:Animals
  36. Adini A, Fainaru O, Udagawa T, Connor KM, Folkman J, D'Amato RJ. Matrigel cytometry: a novel method for quantifying angiogenesis in vivo. J Immunol Methods. 2009 Mar 15; 342(1-2):78-81. PMID: 19109967.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  37. Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, Chen J, Hellstrom A, Smith LE. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. PMID: 18997086.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  38. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. PMID: 18952918.
    Citations: 61     Fields:    Translation:HumansAnimals
  39. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. PMID: 18219389.
    Citations: 104     Fields:    Translation:AnimalsCells
  40. Connor KM, Hempel N, Nelson KK, Dabiri G, Gamarra A, Belarmino J, Van De Water L, Mian BM, Melendez JA. Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res. 2007 Nov 01; 67(21):10260-7. PMID: 17974967.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  41. Chen J, Connor KM, Smith LE. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. PMID: 17909623.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LEH. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. PMID: 17589522.
    Citations: 207     Fields:    Translation:Animals
  43. Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. PMID: 17567756.
    Citations: 67     Fields:    Translation:HumansAnimalsCTClinical Trials
  44. Connor, K.M., Aderman, C.M, Chen, J., Higuchi, A., SanGiovanni, J.-P., Chew, E.Y., Carper, D., Salem, N., Smith, L.E.H. Dietary omega-3 Long-Chain Polyunsaturated Fatty Acids Protect Against Pathological Retinal Neovascularization Through Modulation of Microglial Derived TNF-alpha. The Association for Research in Vision and Ophthalmology Annual Meeting. 2007.
  45. Lofqvist, C, Chen, C, Connor, K.M., Smith, A.C.H, Aderman, C.M, Liu, N, Pintar, J.E, Ludwig, T, Hellstrom, A, Smith, L.E.H. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. PNAS. 2007; 104(25):10589-94.
  46. Connor, K.M., Aderman, C.M., Chen, J., Higuchi, A., SanGiovanni, J-P., Serhan, C.N., Smith, L.E.H. . Increasing dietary omega-3 PUFA reduces pathological angiogenesis via regulation of local resolvins, protectins and TNF-alpha. Society for Free Radical Biology and Medicine 13th Annual Meeting. 2006.
  47. Dasgupta J, Subbaram S, Connor KM, Rodriguez AM, Tirosh O, Beckman JS, Jourd'Heuil D, Melendez JA. Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2. Antioxid Redox Signal. 2006 Jul-Aug; 8(7-8):1295-305. PMID: 16910777.
    Citations: 29     Fields:    Translation:HumansCells
  48. Connor, K.M., Aderman, C.M, Chen, SanGiovanni, J.-P., Chew, E.Y., Carper, D., Salem, N., Smith, L.E.H. . Dietary and Pharmalogic intervention in Proliferative Retinopathy. The Association for Research in Vision and Ophthalmology Annual Meeting. 2006.
  49. Nelson KK, Subbaram S, Connor KM, Dasgupta J, Ha XF, Meng TC, Tonks NK, Melendez JA. Redox-dependent matrix metalloproteinase-1 expression is regulated by JNK through Ets and AP-1 promoter motifs. J Biol Chem. 2006 May 19; 281(20):14100-10. PMID: 16569638.
    Citations: 25     Fields:    Translation:HumansCells
  50. Smith, L.E. and Connor, K.M. . A Radical Twist in Lipid Mediated Vascular Death. Nature Medicine. 2005; 11(12):1276-6.
  51. Smith LE, Connor KM. A radically twisted lipid regulates vascular death. Nat Med. 2005 Dec; 11(12):1275-6. PMID: 16333261.
    Citations: 1     Fields:    Translation:Humans
  52. Kip M Connor. Manganese Superoxide Dismutase Regulates the Malignant Phenotype through the Production of Mitochondrial Derived Hydrogen Peroxide. 2005.
  53. Connor, K.M., Sita Subbaram, Kevin J. Regan, Kristin K. Nelson, Joseph E. Mazurkiewicz, Peter J. Bartholomew, Andrew E. Aplin, Yu-Tzu Tai, Julio Aguirre-Ghiso, Sonia C. Flores and J. Andres Melendez. Sod2-derived H2O2 Regulates the Angiogenic Phenotype via PTEN Oxidation. Journal of Biological Chemistry. 2005; 280(17):16916-24.
  54. Connor KM, Subbaram S, Regan KJ, Nelson KK, Mazurkiewicz JE, Bartholomew PJ, Aplin AE, Tai YT, Aguirre-Ghiso J, Flores SC, Melendez JA. Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation. J Biol Chem. 2005 Apr 29; 280(17):16916-24. PMID: 15701646.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  55. Connor, K.M., Mazurkiewicz J.E., Melendez, J.A. . Mitochondrial-derived H2O2 mediates the cellular redistribution of phosphoinositides. Society for Free Radical Biology and Medicine 11th Annual Meeting. 2004.
  56. Connor, K.M., Regan K., Nelson, K., Goswami, P., Melendez, J.A. . Hydrogen Peroxide Regulates the PI3K Signaling Cascade via Oxidation of the Tumor Suppressor PTEN. American Association for Cancer Research. 2004.
  57. Connor, K.M., Nelson, K.K., Melendez, J.A. . Mitochondrial-derived Hydrogen Peroxide Regulates PI3K Signaling via PTEN Oxidation. Society for Free Radical Biology and Medicine 10th Annual Meeting. 2003.
  58. Connor, K.M., Nelson, K.K., Goswami, Prabat, Melendez, J.A. . Sod2-Derrived Hydrogen Peroxide Regulates the PI3K Signaling Cascade. Pathobiology of Cancer Workshop, AACR. 2003.
  59. Connor, K.M., Nelson, K.K., Regan, Kevin J., Lotz, S.A., Goswami, P., Melendez, J.A. . Potential Mechanism for the Catalase-dependent Inhibition of Tumor Growth. 9th Annual Meeting of the Oxygen Society. 2002.
  60. Connor, K.M., Rodriguez, A.M., Bennett, J.A., Melendez, J.A. . Inhibition of Tumor Growth by the expression of Mitochondrial Catalase: The Role of Hydrogen Peroxide in Regulating Caspase Activation. 8th Annual Meeting of The Oxygen Society. 2001.
  61. Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000 Dec 21-28; 408(6815):982-5. PMID: 11140686.
    Citations: 392     Fields:    Translation:HumansAnimalsPHPublic Health
  62. Miller J, Connor K. Going to the dogs ... for help. Nursing. 2000 Nov; 30(11):65-7. PMID: 11111661.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  63. Connor K, Miller J. Help from our animal friends. Nurs Manage. 2000 Jul; 31(7):42-6. PMID: 15127507.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  64. Connor K, Miller J. Animal-assisted therapy: an in-depth look. Dimens Crit Care Nurs. 2000 May-Jun; 19(3):20-6. PMID: 11998003.
    Citations:    Fields:    Translation:HumansAnimals
  65. Begara-McGorum I, Wildblood LA, Clarke CJ, Connor KM, Stevenson K, McInnes CJ, Sharp JM, Jones DG. Early immunopathological events in experimental ovine paratuberculosis. Vet Immunol Immunopathol. 1998 May 29; 63(3):265-87. PMID: 9656460.
    Citations:    
  66. Harper N, Connor K, Steinberg M, Safe S. An enzyme-linked immunosorbent assay (ELISA) specific for antibodies to TNP-LPS detects alterations in serum immunoglobulins and isotype switching in C57BL/6 and DBA/2 mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds. Toxicology. 1994 Sep 06; 92(1-3):155-67. PMID: 7940557.
    Citations:    Fields:    Translation:AnimalsCells
  67. Cheng YC, Grill S, Derse D, Chen JY, Caradonna SJ, Connor K. Mode of action of phosphonoformate as an anti-herpes simplex virus agent. Biochim Biophys Acta. 1981 Jan 29; 652(1):90-8. PMID: 6260189.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.