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Nima Saeidi, Ph.D.


2012 - 2015
NIH-NIDDK F32 Postdoctoral Fellowship

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK123219 (SAEIDI, NIMA) Jul 1, 2020 - May 31, 2024
    Central and direct role of the small intestine in the improvement of type 2 diabetes following RYGB
    Role: Principal Investigator
  2. R21OD029996 (STYLOPOULOS, NICHOLAS) Jul 1, 2020 - Jun 30, 2022
    The Burmese Python as a Model System for the Study of Metabolism and Organ Regeneration
    Role: Co-Principal Investigator
  3. R01EY028234 (SAEIDI, NIMA) Sep 30, 2017 - Jul 31, 2022
    A Cell-free Approach to the Engineering of Corneal Stroma
    Role: Principal Investigator
  4. K01DK103947 (SAEIDI, NIMA) Jul 1, 2015 - Jun 30, 2018
    Gastrointestinal Weight Loss Surgery Regulates Glucose Metabolism via Intestinal Metabolic Remodeling
    Role: Principal Investigator
  5. F32DK095558 (SAEIDI, NIMA) Jul 1, 2012 - Jun 30, 2015
    The Role of Adipose Tissue Remodeling in Surgically-Induced Weight Loss
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. He S, Azar DA, Esfahani FN, Azar GA, Shazly T, Saeidi N. Mechanoscopy: A Novel Device and Procedure for in vivo Detection of Chronic Colitis in Mice. Inflamm Bowel Dis. 2022 Aug 01; 28(8):1143-1150. PMID: 35325126; PMCID: PMC9340527.
    Citations:    Fields:    
  2. Spencer RKW, Ha BY, Saeidi N. Interplay between nematic and cholesteric interactions in self-consistent field theory. Phys Rev E. 2022 May; 105(5-1):054501. PMID: 35706232.
    Citations:    Fields:    
  3. Lei P, Chukwudi C, Pannu PR, He S, Saeidi N. Rewiring of the Liver Transcriptome across Multiple Time-Scales Is Associated with the Weight Loss-Independent Resolution of NAFLD Following RYGB. Metabolites. 2022 Apr 02; 12(4). PMID: 35448506; PMCID: PMC9025796.
  4. Spencer RKW, Ha BY, Saeidi N. Self-consistent field theory of chiral nematic worm-like chains. J Chem Phys. 2022 Mar 21; 156(11):114902. PMID: 35317576; PMCID: PMC8934192.
    Citations:    Fields:    
  5. Saeidi N, Stefater M, Stylopoulos N. Effect of Diet versus Gastric Bypass on Metabolic Function in Diabetes. N Engl J Med. 2020 12 10; 383(24):2391-2392. PMID: 33296570.
    Citations:    Fields:    Translation:Humans
  6. Spencer RKW, Saeidi N, Ha BY. Nematic ordering of worm-like polymers near an interface. J Chem Phys. 2020 May 29; 152(20):204907. PMID: 32486695.
    Citations: 1     Fields:    
  7. He S, Green Y, Saeidi N, Li X, Fredberg JJ, Ji B, Pismen LM. A theoretical model of collective cell polarization and alignment. J Mech Phys Solids. 2020 Apr; 137. PMID: 33518805.
    Citations: 3     
  8. Krishnan S, Ding Y, Saeidi N, Choi M, Sridharan GV, Sherr DH, Yarmush ML, Alaniz RC, Jayaraman A, Lee K. Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages. Cell Rep. 2019 Sep 17; 28(12):3285. PMID: 31533048.
    Citations: 6     Fields:    
  9. Li X, Saeidi N, Villiger M, Albadawi H, Jones JD, Quinn KP, Austin WG, Golberg A, Yarmush ML. Rejuvenation of aged rat skin with pulsed electric fields. J Tissue Eng Regen Med. 2018 12; 12(12):2309-2318. PMID: 30353675.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Meoli L, Gupta NK, Saeidi N, Panciotti CA, Biddinger SB, Corey KE, Stylopoulos N. Nonalcoholic fatty liver disease and gastric bypass surgery regulate serum and hepatic levels of pyruvate kinase isoenzyme M2. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E613-E621. PMID: 29462566; PMCID: PMC6230703.
    Citations: 4     Fields:    Translation:HumansAnimals
  11. Sridharan GV, Bruinsma BG, Bale SS, Swaminathan A, Saeidi N, Yarmush ML, Uygun K. Metabolomic Modularity Analysis (MMA) to Quantify Human Liver Perfusion Dynamics. Metabolites. 2017 11 13; 7(4). PMID: 29137180; PMCID: PMC5746738.
    Citations: 4     
  12. Sridharan GV, D'Alessandro M, Bale SS, Bhagat V, Gagnon H, Asara JM, Uygun K, Yarmush ML, Saeidi N. Multi-omic network-based interrogation of rat liver metabolism following gastric bypass surgery featuring SWATH proteomics. Technology (Singap World Sci). 2017 Sep; 5(3):139-184. PMID: 29780857; PMCID: PMC5956888.
    Citations: 1     
  13. Yarmush ML, D'Alessandro M, Saeidi N. Regulation of Energy Homeostasis After Gastric Bypass Surgery. Annu Rev Biomed Eng. 2017 06 21; 19:459-484. PMID: 28633561.
    Citations: 5     Fields:    Translation:Humans
  14. Zareian R, Susilo ME, Paten JA, McLean JP, Hollmann J, Karamichos D, Messer CS, Tambe DT, Saeidi N, Zieske JD, Ruberti JW. Human Corneal Fibroblast Pattern Evolution and Matrix Synthesis on Mechanically Biased Substrates. Tissue Eng Part A. 2016 10; 22(19-20):1204-1217. PMID: 27600605; PMCID: PMC5073220.
    Citations: 7     Fields:    Translation:HumansCells
  15. Bruinsma BG, Sridharan GV, Weeder PD, Avruch JH, Saeidi N, Özer S, Geerts S, Porte RJ, Heger M, van Gulik TM, Martins PN, Markmann JF, Yeh H, Uygun K. Metabolic profiling during ex vivo machine perfusion of the human liver. Sci Rep. 2016 Mar 03; 6:22415. PMID: 26935866.
    Citations: 43     Fields:    Translation:Humans
  16. Bruinsma BG, Uygun K, Yarmush ML, Saeidi N. Surgical models of Roux-en-Y gastric bypass surgery and sleeve gastrectomy in rats and mice. Nat Protoc. 2015 Mar; 10(3):495-507. PMID: 25719268.
    Citations: 34     Fields:    Translation:Animals
  17. Fletcher AL, Elman JS, Astarita J, Murray R, Saeidi N, D'Rozario J, Knoblich K, Brown FD, Schildberg FA, Nieves JM, Heng TS, Boyd RL, Turley SJ, Parekkadan B. Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis. Sci Transl Med. 2014 Aug 13; 6(249):249ra109. PMID: 25122637.
    Citations: 18     Fields:    Translation:AnimalsCells
  18. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919.
    Citations: 44     Fields:    Translation:Animals
  19. Bruinsma BG, Yeh H, Ozer S, Martins PN, Farmer A, Wu W, Saeidi N, Op den Dries S, Berendsen TA, Smith RN, Markmann JF, Porte RJ, Yarmush ML, Uygun K, Izamis ML. Subnormothermic machine perfusion for ex vivo preservation and recovery of the human liver for transplantation. Am J Transplant. 2014 Jun; 14(6):1400-9. PMID: 24758155.
    Citations: 69     Fields:    Translation:Humans
  20. Saeidi N, Meoli L, Nestoridi E, Gupta NK, Kvas S, Kucharczyk J, Bonab AA, Fischman AJ, Yarmush ML, Stylopoulos N. Reprogramming of intestinal glucose metabolism and glycemic control in rats after gastric bypass. Science. 2013 Jul 26; 341(6144):406-10. PMID: 23888041.
    Citations: 152     Fields:    Translation:AnimalsCells
  21. Izamis ML, Calhoun C, Uygun BE, Guzzardi MA, Saeidi N, Price G, Yarmush ML, Uygun K. Simple Machine Perfusion Significantly Enhances Hepatocyte Yields of Ischemic and Fresh Rat Livers. Cell Medicine. 2013; 4(15):109-123.
  22. Izamis ML, Calhoun C, Uygun BE, Guzzardi MA, Price G, Luitje M, Saeidi N, Yarmush ML, Uygun K. SIMPLE MACHINE PERFUSION SIGNIFICANTLY ENHANCES HEPATOCYTE YIELDS OF ISCHEMIC AND FRESH RAT LIVERS. Cell Med. 2013; 4(3):109-123. PMID: 25431743; PMCID: PMC4243527.
    Citations: 7     
  23. Saeidi N, Nestoridi E, Kucharczyk J, Uygun MK, Yarmush ML, Stylopoulos N. Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats. Int J Obes (Lond). 2012 Nov; 36(11):1396-402. PMID: 23044855.
    Citations: 44     Fields:    Translation:Animals
  24. Saeidi N, Karmelek KP, Paten JA, Zareian R, DiMasi E, Ruberti JW. Molecular crowding of collagen: a pathway to produce highly-organized collagenous structures. Biomaterials. 2012 Oct; 33(30):7366-74. PMID: 22846420.
    Citations: 23     Fields:    
  25. Saeidi N, Guo X, Hutcheon AE, Sander EA, Bale SS, Melotti SA, Zieske JD, Trinkaus-Randall V, Ruberti JW. Disorganized collagen scaffold interferes with fibroblast mediated deposition of organized extracellular matrix in vitro. Biotechnol Bioeng. 2012 Oct; 109(10):2683-98. PMID: 22528405.
    Citations: 21     Fields:    Translation:HumansCells
  26. Paten JA, Zareian R, Saeidi N, Melotti SA, Ruberti JW. Design and performance of an optically accessible, low-volume, mechanobioreactor for long-term study of living constructs. Tissue Eng Part C Methods. 2011 Jul; 17(7):775-88. PMID: 21413901.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Saeidi N, Sander EA, Zareian R, Ruberti JW. Production of highly aligned collagen lamellae by combining shear force and thin film confinement. Acta Biomater. 2011 Jun; 7(6):2437-47. PMID: 21362500.
    Citations: 13     Fields:    
  28. Camp RJ, Liles M, Beale J, Saeidi N, Flynn BP, Moore E, Murthy SK, Ruberti JW. Molecular mechanochemistry: low force switch slows enzymatic cleavage of human type I collagen monomer. J Am Chem Soc. 2011 Mar 23; 133(11):4073-8. PMID: 21348512.
    Citations: 37     Fields:    Translation:HumansCells
  29. Uygun BE, Price G, Saedi N, Izamis ML, Berendsen T, Yarmush M, Uygun K. Decellularization and recellularization of whole livers. J Vis Exp. 2011 Feb 04; (48). PMID: 21339718.
    Citations: 14     Fields:    Translation:Animals
  30. Izamis ML, Sharma NS, Uygun B, Bieganski R, Saeidi N, Nahmias Y, Uygun K, Yarmush ML, Berthiaume F. In situ metabolic flux analysis to quantify the liver metabolic response to experimental burn injury. Biotechnol Bioeng. 2011 Apr; 108(4):839-52. PMID: 21404258.
    Citations: 18     Fields:    Translation:AnimalsCells
  31. Flynn BP, Bhole AP, Saeidi N, Liles M, Dimarzio CA, Ruberti JW. Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8). PLoS One. 2010 Aug 23; 5(8):e12337. PMID: 20808784.
    Citations: 74     Fields:    Translation:HumansAnimals
  32. Zareian R, Church KP, Saeidi N, Flynn BP, Beale JW, Ruberti JW. Probing collagen/enzyme mechanochemistry in native tissue with dynamic, enzyme-induced creep. Langmuir. 2010 Jun 15; 26(12):9917-26. PMID: 20429513.
    Citations: 21     Fields:    Translation:AnimalsCells
  33. Bueno EM, Saeidi N, Melotti S, Ruberti JW. Effect of serum and insulin modulation on the organization and morphology of matrix synthesized by bovine corneal stromal cells. Tissue Eng Part A. 2009 Nov; 15(11):3559-73. PMID: 19480568.
    Citations: 3     Fields:    Translation:AnimalsCells
  34. Saeidi N, Sander EA, Ruberti JW. Dynamic shear-influenced collagen self-assembly. Biomaterials. 2009 Dec; 30(34):6581-92. PMID: 19765820.
    Citations: 22     Fields:    Translation:AnimalsCells
  35. Bhole AP, Flynn BP, Liles M, Saeidi N, Dimarzio CA, Ruberti JW. Mechanical strain enhances survivability of collagen micronetworks in the presence of collagenase: implications for load-bearing matrix growth and stability. Philos Trans A Math Phys Eng Sci. 2009 Sep 13; 367(1902):3339-62. PMID: 19657003.
    Citations: 42     Fields:    Translation:Animals
  36. Zareian R, Saeidi N, Ruberti JW. Strain-Influenced Degradation of Native Collagenous Tissue in a Very-Low Volume, Environmentally-Controlled Bioreactor. ASME Conference Proceedings. 2009; 2009(43758):113-118.
  37. Ren R, Hutcheon AE, Guo XQ, Saeidi N, Melotti SA, Ruberti JW, Zieske JD, Trinkaus-Randall V. Human primary corneal fibroblasts synthesize and deposit proteoglycans in long-term 3-D cultures. Dev Dyn. 2008 Oct; 237(10):2705-15. PMID: 18624285.
    Citations: 43     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.