Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Shobha Vasudevan, Ph.D.

Title
Institution
Department
Address

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R35GM134944 (VASUDEVAN, SHOBHA) Jun 9, 2020 - Mar 31, 2025
    NIH/NIGMS
    Specialized post-transcriptional mechanisms of gene expression in quiescence
    Role: Principal Investigator
  2. R21CA220103 (VASUDEVAN, SHOBHA) Jan 15, 2020 - Dec 31, 2021
    NIH/NCI
    Role of RNA methylation in chemoresistant cancer cells
    Role: Principal Investigator
  3. R01GM100202 (VASUDEVAN, SHOBHA) Feb 13, 2015 - Jan 31, 2020
    NIH/NIGMS
    Post-transcriptional Gene Expression of the TNF alpha by an FXR1a-associated microRNP
    Role: Principal Investigator
  4. R01CA185086 (VASUDEVAN, SHOBHA) Jun 1, 2014 - May 31, 2018
    NIH/NCI
    (PQC6) Molecular Determinants of Quiescent Cancer Cells
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen H, Yang H, Zhu X, Yadav T, Ouyang J, Truesdell SS, Tan J, Wang Y, Duan M, Wei L, Zou L, Levine AS, Vasudevan S, Lan L. m5C modification of mRNA serves a DNA damage code to promote homologous recombination. Nat Commun. 2020 06 05; 11(1):2834. PMID: 32503981.
    Citations:    
  2. Lee S, Micalizzi D, Truesdell SS, Bukhari SIA, Boukhali M, Lombardi-Story J, Kato Y, Choo MK, Dey-Guha I, Ji F, Nicholson BT, Myers DT, Lee D, Mazzola MA, Raheja R, Langenbucher A, Haradhvala NJ, Lawrence MS, Gandhi R, Tiedje C, Diaz-Muñoz MD, Sweetser DA, Sadreyev R, Sykes D, Haas W, Haber DA, Maheswaran S, Vasudevan S. A post-transcriptional program of chemoresistance by AU-rich elements and TTP in quiescent leukemic cells. Genome Biol. 2020 02 10; 21(1):33. PMID: 32039742.
    Citations:    
  3. Ebright RY, Lee S, Wittner BS, Niederhoffer KL, Nicholson BT, Bardia A, Truesdell S, Wiley DF, Wesley B, Li S, Mai A, Aceto N, Vincent-Jordan N, Szabolcs A, Chirn B, Kreuzer J, Comaills V, Kalinich M, Haas W, Ting DT, Toner M, Vasudevan S, Haber DA, Maheswaran S, Micalizzi DS. Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis. Science. 2020 03 27; 367(6485):1468-1473. PMID: 32029688.
    Citations:    
  4. Li B, Clohisey SM, Chia BS, Wang B, Cui A, Eisenhaure T, Schweitzer LD, Hoover P, Parkinson NJ, Nachshon A, Smith N, Regan T, Farr D, Gutmann MU, Bukhari SI, Law A, Sangesland M, Gat-Viks I, Digard P, Vasudevan S, Lingwood D, Dockrell DH, Doench JG, Baillie JK, Hacohen N. Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection. Nat Commun. 2020 01 09; 11(1):164. PMID: 31919360.
    Citations:    
  5. Chery J, Petri A, Wagschal A, Lim SY, Cunningham J, Vasudevan S, Kauppinen S, Näär AM. Development of Locked Nucleic Acid Antisense Oligonucleotides Targeting Ebola Viral Proteins and Host Factor Niemann-Pick C1. Nucleic Acid Ther. 2018 10; 28(5):273-284. PMID: 30133337.
    Citations:    Fields:    
  6. Bukhari SIA, Truesdell SS, Vasudevan S. Analysis of MicroRNA-Mediated Translation Activation of In Vitro Transcribed Reporters in Quiescent Cells. Methods Mol Biol. 2018; 1686:251-264. PMID: 29030826.
    Citations: 1     Fields:    Translation:HumansCells
  7. Martinez I, Hayes KE, Barr JA, Harold AD, Xie M, Bukhari SIA, Vasudevan S, Steitz JA, DiMaio D. An Exportin-1-dependent microRNA biogenesis pathway during human cell quiescence. Proc Natl Acad Sci U S A. 2017 06 20; 114(25):E4961-E4970. PMID: 28584122.
    Citations: 6     Fields:    Translation:HumansCells
  8. Bukhari SI, Vasudevan S. FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions. RNA Biol. 2017 02; 14(2):137-145. PMID: 27911187.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Le Tonqueze O, Kollu S, Lee S, Al-Salah M, Truesdell SS, Vasudevan S. Regulation of monocyte induced cell migration by the RNA binding protein, FXR1. Cell Cycle. 2016 07 17; 15(14):1874-82. PMID: 27229378.
    Citations: 3     Fields:    Translation:HumansCells
  10. Bukhari SIA, Truesdell SS, Lee S, Kollu S, Classon A, Boukhali M, Jain E, Mortensen RD, Yanagiya A, Sadreyev RI, Haas W, Vasudevan S. A Specialized Mechanism of Translation Mediated by FXR1a-Associated MicroRNP in Cellular Quiescence. Mol Cell. 2016 Mar 03; 61(5):760-773. PMID: 26942679.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  11. Solé X, Alves CP, Dey-Guha I, Ritsma L, Boukhali M, Lee JH, Chowdhury J, Ross KN, Haas W, Vasudevan S, Ramaswamy S. AKT Inhibition Promotes Nonautonomous Cancer Cell Survival. Mol Cancer Ther. 2016 Jan; 15(1):142-53. PMID: 26637368.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  12. Lee S, Truesdell SS, Bukhari SI, Lee JH, LeTonqueze O, Vasudevan S. Upregulation of eIF5B controls cell-cycle arrest and specific developmental stages. Proc Natl Acad Sci U S A. 2014 Oct 14; 111(41):E4315-22. PMID: 25261552.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA. The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev. 2013 Dec 01; 27(23):2543-8. PMID: 24298054.
    Citations: 32     Fields:    Translation:HumansCells
  14. Lee S, Vasudevan S. Post-transcriptional stimulation of gene expression by microRNAs. Adv Exp Med Biol. 2013; 768:97-126. PMID: 23224967.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  15. Truesdell SS, Mortensen RD, Seo M, Schroeder JC, Lee JH, LeTonqueze O, Vasudevan S. MicroRNA-mediated mRNA translation activation in quiescent cells and oocytes involves recruitment of a nuclear microRNP. Sci Rep. 2012; 2:842. PMID: 23150790.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  16. Vasudevan S. Functional validation of microRNA-target RNA interactions. Methods. 2012 Oct; 58(2):126-34. PMID: 22910526.
    Citations: 7     Fields:    Translation:HumansCells
  17. Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 01; 26(13):1459-72. PMID: 22751500.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  18. Letonqueze O, Lee J, Vasudevan S. MicroRNA-mediated posttranscriptional mechanisms of gene expression in proliferating and quiescent cancer cells. RNA Biol. 2012 Jun; 9(6):871-80. PMID: 22699554.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Vasudevan S. Posttranscriptional upregulation by microRNAs. Wiley Interdiscip Rev RNA. 2012 May-Jun; 3(3):311-30. PMID: 22072587.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  20. Mortensen RD, Serra M, Steitz JA, Vasudevan S. Posttranscriptional activation of gene expression in Xenopus laevis oocytes by microRNA-protein complexes (microRNPs). Proc Natl Acad Sci U S A. 2011 May 17; 108(20):8281-6. PMID: 21536868.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  21. Steitz JA, Vasudevan S. miRNPs: versatile regulators of gene expression in vertebrate cells. Biochem Soc Trans. 2009 Oct; 37(Pt 5):931-5. PMID: 19754429.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  22. Vasudevan S, Tong Y, Steitz JA. Cell-cycle control of microRNA-mediated translation regulation. Cell Cycle. 2008 Jun 01; 7(11):1545-9. PMID: 18469529.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  23. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: microRNAs can up-regulate translation. Science. 2007 Dec 21; 318(5858):1931-4. PMID: 18048652.
    Citations: 905     Fields:    Translation:HumansCells
  24. Vasudevan S, Steitz JA. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell. 2007 Mar 23; 128(6):1105-18. PMID: 17382880.
    Citations: 222     Fields:    Translation:HumansCells
  25. Vasudevan S, Seli E, Steitz JA. Metazoan oocyte and early embryo development program: a progression through translation regulatory cascades. Genes Dev. 2006 Jan 15; 20(2):138-46. PMID: 16418480.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  26. Vasudevan S, Garneau N, Tu Khounh D, Peltz SW. p38 mitogen-activated protein kinase/Hog1p regulates translation of the AU-rich-element-bearing MFA2 transcript. Mol Cell Biol. 2005 Nov; 25(22):9753-63. PMID: 16260593.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Duttagupta R, Vasudevan S, Wilusz CJ, Peltz SW. A yeast homologue of Hsp70, Ssa1p, regulates turnover of the MFA2 transcript through its AU-rich 3' untranslated region. Mol Cell Biol. 2003 Apr; 23(8):2623-32. PMID: 12665566.
    Citations: 14     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Vasudevan's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (177)
Explore
_
Co-Authors (22)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
© 2020 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.