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Anna Greka, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK099465 (GREKA, ANNA) Sep 20, 2014 - Jul 31, 2023
    Ion-channel targeted therapy for progressive kidney diseases
    Role: Principal Investigator
  2. R01DK095045 (GREKA, ANNA) Mar 10, 2014 - Jan 31, 2020
    Molecular mechanisms of AT1R signaling in FSGS
    Role: Principal Investigator
  3. R56DK093746 (GREKA, ANNA) Sep 25, 2012 - Aug 31, 2014
    TRPC-mediated calcium signaling in podocytes
    Role: Principal Investigator
  4. K08DK083511 (GREKA, ANNA) May 15, 2010 - Mar 31, 2015
    TRPC channels in proteinuric kidney disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alimova M, Sidhom EH, Satyam A, Dvela-Levitt M, Melanson M, Chamberlain BT, Alper SL, Santos J, Gutierrez J, Subramanian A, Grinkevich E, Bricio ER, Kim C, Clark A, Watts A, Thompson R, Marshall J, Pablo JL, Coraor J, Roignot J, Vernon KA, Keller K, Campbell A, Emani M, Racette M, Bazua-Valenti S, Padovano V, Weins A, McAdoo SP, Tam FWK, Ronco L, Wagner F, Tsokos GC, Shaw JL, Greka A. A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic. bioRxiv. 2020 Jun 30. PMID: 32637960.
  2. Olinger E, Hofmann P, Kidd K, Dufour I, Belge H, Schaeffer C, Kipp A, Bonny O, Deltas C, Demoulin N, Fehr T, Fuster DG, Gale DP, Goffin E, Hodanová K, Huynh-Do U, Kistler A, Morelle J, Papagregoriou G, Pirson Y, Sandford R, Sayer JA, Torra R, Venzin C, Venzin R, Vogt B, Živná M, Greka A, Dahan K, Rampoldi L, Kmoch S, Bleyer AJ, Devuyst O. Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutations in UMOD and MUC1. Kidney Int. 2020 09; 98(3):717-731. PMID: 32450155.
  3. Clark AR, Greka A. The power of one: advances in single-cell genomics in the kidney. Nat Rev Nephrol. 2020 02; 16(2):73-74. PMID: 31819231.
  4. Subramanian A, Sidhom EH, Emani M, Vernon K, Sahakian N, Zhou Y, Kost-Alimova M, Slyper M, Waldman J, Dionne D, Nguyen LT, Weins A, Marshall JL, Rosenblatt-Rosen O, Regev A, Greka A. Single cell census of human kidney organoids shows reproducibility and diminished off-target cells after transplantation. Nat Commun. 2019 11 29; 10(1):5462. PMID: 31784515.
  5. Pablo JL, Greka A. Charting a TRP to Novel Therapeutic Destinations for Kidney Diseases. Trends Pharmacol Sci. 2019 12; 40(12):911-918. PMID: 31704171.
  6. Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019 07 25; 178(3):521-535.e23. PMID: 31348885.
  7. Bleyer AJ, Kidd K, Robins V, Martin L, Taylor A, Santi A, Tsoumas G, Hunt A, Swain E, Abbas M, Akinbola E, Vidya S, Moossavi S, Bleyer AJ, Živná M, Hartmannová H, Hodanová K, Vyletal P, Votruba M, Harden M, Blumenstiel B, Greka A, Kmoch S. Outcomes of patient self-referral for the diagnosis of several rare inherited kidney diseases. Genet Med. 2020 01; 22(1):142-149. PMID: 31337885.
  8. Bleyer AJ, Kmoch S, Greka A. Diagnostic Utility of Exome Sequencing for Kidney Disease. N Engl J Med. 2019 05 23; 380(21):2080. PMID: 31116938.
  9. Sharma SH, Pablo JL, Montesinos MS, Greka A, Hopkins CR. Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett. 2019 01 15; 29(2):155-159. PMID: 30538066.
    Citations:    Fields:    
  10. Wang L, Fu TM, Zhou Y, Xia S, Greka A, Wu H. Structures and gating mechanism of human TRPM2. Science. 2018 12 21; 362(6421). PMID: 30467180.
    Citations:    Fields:    
  11. Živná M, Kidd K, Pristoupilová A, Barešová V, DeFelice M, Blumenstiel B, Harden M, Conlon P, Lavin P, Connaughton DM, Hartmannová H, Hodanová K, Stránecký V, Vrbacká A, Vyletal P, Živný J, Votruba M, Sovová J, Hulková H, Robins V, Perry R, Wenzel A, Beck BB, Seeman T, Viklický O, Rajnochová-Bloudícková S, Papagregoriou G, Deltas CC, Alper SL, Greka A, Bleyer AJ, Kmoch S. Noninvasive Immunohistochemical Diagnosis and Novel MUC1 Mutations Causing Autosomal Dominant Tubulointerstitial Kidney Disease. J Am Soc Nephrol. 2018 09; 29(9):2418-2431. PMID: 29967284.
    Citations: 1     Fields:    
  12. Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018 02 22; 3(4). PMID: 29467330.
    Citations: 1     Fields:    
  13. Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A. GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death. Cell Chem Biol. 2018 02 15; 25(2):175-184.e4. PMID: 29249695.
    Citations: 4     Fields:    Translation:HumansCells
  14. Zhou Y, Castonguay P, Sidhom EH, Clark AR, Dvela-Levitt M, Kim S, Sieber J, Wieder N, Jung JY, Andreeva S, Reichardt J, Dubois F, Hoffmann SC, Basgen JM, Montesinos MS, Weins A, Johnson AC, Lander ES, Garrett MR, Hopkins CR, Greka A. A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models. Science. 2017 12 08; 358(6368):1332-1336. PMID: 29217578.
    Citations: 13     Fields:    Translation:AnimalsCells
  15. Sieber J, Wieder N, Ostrosky-Frid M, Dvela-Levitt M, Aygün O, Udeshi ND, Carr SA, Greka A. Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress. J Biol Chem. 2017 11 17; 292(46):18878-18885. PMID: 28912266.
    Citations:    Fields:    Translation:AnimalsCells
  16. Trachtman H, Gipson DS, Somers M, Spino C, Adler S, Holzman L, Kopp JB, Sedor J, Overfield S, Elegbe A, Maldonado M, Greka A. Randomized Clinical Trial Design to Assess Abatacept in Resistant Nephrotic Syndrome. Kidney Int Rep. 2018 Jan; 3(1):115-121. PMID: 29340321.
  17. Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, Wang J, Qin Y, Liu Y, Tang C, He L, Greka A, Zhou Z, Liu F, Dong Z, Sun L. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Redox Biol. 2017 04; 11:297-311. PMID: 28033563.
    Citations: 19     Fields:    Translation:AnimalsCells
  18. Siddiqui B, Greka A, Popovtzer M, Rennke HG, Jeselsohn R. Immune Complex-Mediated Proliferative Glomerulonephritis Induced by Paclitaxel Treatment. J Oncol Pract. 2016 12; 12(12):1272-1274. PMID: 27845869.
    Citations:    Fields:    Translation:Humans
  19. Greka A, Gibson D, Mundel P, Demetri G, Hildebrandt F, Pollak M, Florez J. Personalized Comments on Challenges and Opportunities in Kidney Disease Therapeutics: The Glom-NExT Symposium. Semin Nephrol. 2016 11; 36(6):448. PMID: 27987543.
    Citations: 2     Fields:    Translation:Humans
  20. Greka A. Introduction: Toward Precision Medicines for Kidney Disease. Semin Nephrol. 2016 11; 36(6):435. PMID: 27987540.
    Citations:    Fields:    Translation:Humans
  21. Greka A. An Introduction to the Glom-NExT Inaugural Symposium: Toward Precision Medicine in Nephrology. Semin Nephrol. 2016 11; 36(6):448-452. PMID: 27987542.
    Citations:    Fields:    Translation:HumansCells
  22. Buvall L, Wallentin H, Sieber J, Andreeva S, Choi HY, Mundel P, Greka A. Synaptopodin Is a Coincidence Detector of Tyrosine versus Serine/Threonine Phosphorylation for the Modulation of Rho Protein Crosstalk in Podocytes. J Am Soc Nephrol. 2017 Mar; 28(3):837-851. PMID: 27628902.
    Citations: 12     Fields:    Translation:AnimalsCells
  23. Ryu CW, Coutu JP, Greka A, Rosas HD, Jahng GH, Rosen BR, Salat DH. Differential associations between systemic markers of disease and white matter tissue health in middle-aged and older adults. J Cereb Blood Flow Metab. 2017 Nov; 37(11):3568-3579. PMID: 27298238.
    Citations: 1     Fields:    Translation:HumansCells
  24. Zhou Y, Greka A. Calcium-permeable ion channels in the kidney. Am J Physiol Renal Physiol. 2016 06 01; 310(11):F1157-67. PMID: 27029425.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Greka A. Human genetics of nephrotic syndrome and the quest for precision medicine. Curr Opin Nephrol Hypertens. 2016 Mar; 25(2):138-43. PMID: 26808706.
    Citations: 3     Fields:    Translation:HumansCells
  26. Wieder N, Greka A. Calcium, TRPC channels, and regulation of the actin cytoskeleton in podocytes: towards a future of targeted therapies. Pediatr Nephrol. 2016 07; 31(7):1047-54. PMID: 26490951.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  27. Yoon KW, Byun S, Kwon E, Hwang SY, Chu K, Hiraki M, Jo SH, Weins A, Hakroush S, Cebulla A, Sykes DB, Greka A, Mundel P, Fisher DE, Mandinova A, Lee SW. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. 2015 Jul 31; 349(6247):1261669. PMID: 26228159.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  28. Mundel P, Greka A. Developing therapeutic 'arrows' with the precision of William Tell: the time has come for targeted therapies in kidney disease. Curr Opin Nephrol Hypertens. 2015 Jul; 24(4):388-92. PMID: 26050127.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Greka A, Weins A, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2014 03 27; 370(13):1263-6. PMID: 24670178.
    Citations: 2     Fields:    Translation:Humans
  30. Hoeppner MP, Lundquist A, Pirun M, Meadows JR, Zamani N, Johnson J, Sundström G, Cook A, FitzGerald MG, Swofford R, Mauceli E, Moghadam BT, Greka A, Alföldi J, Abouelleil A, Aftuck L, Bessette D, Berlin A, Brown A, Gearin G, Lui A, Macdonald JP, Priest M, Shea T, Turner-Maier J, Zimmer A, Lander ES, di Palma F, Lindblad-Toh K, Grabherr MG. An improved canine genome and a comprehensive catalogue of coding genes and non-coding transcripts. PLoS One. 2014; 9(3):e91172. PMID: 24625832.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  31. Schaldecker T, Kim S, Tarabanis C, Tian D, Hakroush S, Castonguay P, Ahn W, Wallentin H, Heid H, Hopkins CR, Lindsley CW, Riccio A, Buvall L, Weins A, Greka A. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec; 123(12):5298-309. PMID: 24231357.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  32. Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW, Mundel P. Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med. 2013 Dec 19; 369(25):2416-23. PMID: 24206430.
    Citations: 111     Fields:    Translation:HumansCells
  33. Greka A, Dekker JP, Calderwood SB. Case 4-2013: A man with acute flank pain. N Engl J Med. 2013 06 06; 368(23):2237. PMID: 23738559.
    Citations:    Fields:    Translation:HumansCells
  34. Greka A, Bhatia RS, Sabir SH, Dekker JP. Case records of the Massachusetts General Hospital. Case 4-2013. A 50-year-old man with acute flank pain. N Engl J Med. 2013 Jan 31; 368(5):466-72. PMID: 23343037.
    Citations:    Fields:    Translation:HumansCells
  35. Buvall L, Rashmi P, Lopez-Rivera E, Andreeva S, Weins A, Wallentin H, Greka A, Mundel P. Proteasomal degradation of Nck1 but not Nck2 regulates RhoA activation and actin dynamics. Nat Commun. 2013; 4:2863. PMID: 24287595.
    Citations: 12     Fields:    Translation:HumansCells
  36. Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol. 2012 Nov 21; 13:33. PMID: 23171048.
    Citations: 3     Fields:    Translation:HumansCells
  37. Greka A, Mundel P. Calcium regulates podocyte actin dynamics. Semin Nephrol. 2012 Jul; 32(4):319-26. PMID: 22958486.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  38. Greka A, Mundel P. Cell biology and pathology of podocytes. Annu Rev Physiol. 2012; 74:299-323. PMID: 22054238.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  39. Greka A, Mundel P. Balancing calcium signals through TRPC5 and TRPC6 in podocytes. J Am Soc Nephrol. 2011 Nov; 22(11):1969-80. PMID: 21980113.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  40. Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Pavenstaedt H, Hsu HH, Schlondorff J, Ramos A, Greka A. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal. 2010 Oct 26; 3(145):ra77. PMID: 20978238.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  41. Rhee EP, Souza A, Farrell L, Pollak MR, Lewis GD, Steele DJ, Thadhani R, Clish CB, Greka A, Gerszten RE. Metabolite profiling identifies markers of uremia. J Am Soc Nephrol. 2010 Jun; 21(6):1041-1051. PMID: 20378825.
    Citations: 49     Fields:    Translation:Humans
  42. Möller CC, Wei C, Altintas MM, Li J, Greka A, Ohse T, Pippin JW, Rastaldi MP, Wawersik S, Schiavi S, Henger A, Kretzler M, Shankland SJ, Reiser J. Induction of TRPC6 channel in acquired forms of proteinuric kidney disease. J Am Soc Nephrol. 2007 Jan; 18(1):29-36. PMID: 17167110.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  43. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol. 2004 Aug; 6(8):709-20. PMID: 15258588.
    Citations: 190     Fields:    Translation:HumansCells
  44. Greka A, Navarro B, Oancea E, Duggan A, Clapham DE. TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci. 2003 Aug; 6(8):837-45. PMID: 12858178.
    Citations: 105     Fields:    Translation:AnimalsCells
  45. Oancea E, Bezzerides VJ, Greka A, Clapham DE. Mechanism of persistent protein kinase D1 translocation and activation. Dev Cell. 2003 Apr; 4(4):561-74. PMID: 12689594.
    Citations: 16     Fields:    Translation:HumansCells
  46. Greka A, Lipton SA, Zhang D. Expression of GABA(C) receptor rho1 and rho2 subunits during development of the mouse retina. Eur J Neurosci. 2000 Oct; 12(10):3575-82. PMID: 11029627.
    Citations: 10     Fields:    Translation:AnimalsCells
  47. Greka A, Koolen JA, Lipton SA, Zhang D. Cloning and characterization of mouse GABA(C) receptor subunits. Neuroreport. 1998 Jan 26; 9(2):229-32. PMID: 9507960.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.