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Mohammed Abdul Sattar Khan, Ph.D.

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Biography
awards and honors
1996 - 2000
Monbusho Fellowsip
2000 - 2002
Science and Technology Agency Award
2002 - 2007
Fogarty Visiting Fellow
2009
Partners in Excellence Award

Overview
overview
Oxidative stress and apoptosis is associated with muscle wasting (atrophy) after muscle disuse (immobilization), denervation and burn injury or critical illness. Reactive oxygen species (ROS) that are generated because of oxidative stress may contribute to several kinds of post-translational modification, for instance carbonylation or phosphorylation of proteins and also induce apoptosis by triggering the cascade of apoptotic signaling. These changes can cause decrease in growth factor (insulin) signaling. Skeletal muscle is a major target of insulin action and insulin-stimulated glucose uptake is an important mechanism in the metabolic pathway. Understanding the signaling pathways and identifying the crucial proteins and genes that are responsible and contribute to disuse muscle atrophy is important in developing counter-measures to prevent this form of skeletal muscle wasting and preserve physiological function.

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sakuma M, Khan MAS, Yasuhara S, Martyn JA, Palaniyar N. Mechanism of pulmonary immunosuppression: extrapulmonary burn injury suppresses bacterial endotoxin-induced pulmonary neutrophil recruitment and neutrophil extracellular trap (NET) formation. FASEB J. 2019 12; 33(12):13602-13616. PMID: 31577450; PMCID: PMC6894048.
    Citations: 10     Fields:    Translation:AnimalsCells
  2. Ma L, Zhou Y, Khan MAS, Yasuhara S, Martyn JAJ. Burn-Induced Microglia Activation is Associated With Motor Neuron Degeneration and Muscle Wasting in Mice. Shock. 2019 05; 51(5):569-579. PMID: 30702509.
    Citations: 9     Fields:    Translation:AnimalsCells
  3. Schaller SJ, Nagashima M, Schönfelder M, Sasakawa T, Schulz F, Khan MAS, Kem WR, Schneider G, Schlegel J, Lewald H, Blobner M, Jeevendra Martyn JA. GTS-21 attenuates loss of body mass, muscle mass, and function in rats having systemic inflammation with and without disuse atrophy. Pflugers Arch. 2018 11; 470(11):1647-1657. PMID: 30006848; PMCID: PMC6330254.
    Citations: 6     Fields:    Translation:Animals
  4. Khan MAS, Khan MF, Kashiwagi S, Kem WR, Yasuhara S, Kaneki M, Tompkins RG, Martyn JAJ. An ALPHA7 Nicotinic Acetylcholine Receptor Agonist (GTS-21) Promotes C2C12 Myonuclear Accretion in Association with Release of Interleukin-6 (IL-6) and Improves Survival in Burned Mice. Shock. 2017 08; 48(2):227-235. PMID: 28282360.
    Citations: 6     Fields:    Translation:AnimalsCells
  5. Kashiwagi S, Khan MA, Yasuhara S, Goto T, Kem WR, Tompkins RG, Kaneki M, Martyn JA. Prevention of Burn-Induced Inflammatory Responses and Muscle Wasting by GTS-21, a Specific Agonist for a7 Nicotinic Acetylcholine Receptors. Shock. 2017 01; 47(1):61-69. PMID: 27529131.
    Citations: 18     Fields:    Translation:Animals
  6. Ueki R, Liu L, Kashiwagi S, Kaneki M, Khan MA, Hirose M, Tompkins RG, Martyn JA, Yasuhara S. Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction: Protective Effects of Glycyrrhizin. Shock. 2016 10; 46(4):382-9. PMID: 27172157.
    Citations: 5     Fields:    Translation:AnimalsCells
  7. Lee S, Yang HS, Sasakawa T, Khan MA, Khatri A, Kaneki M, Martyn JA. Immobilization with atrophy induces de novo expression of neuronal nicotinic a7 acetylcholine receptors in muscle contributing to neurotransmission. Anesthesiology. 2014 Jan; 120(1):76-85. PMID: 24126263; PMCID: PMC3910258.
    Citations: 10     Fields:    Translation:AnimalsCells
  8. Khan MA, Sahani N, Neville KA, Nagashima M, Lee S, Sasakawa T, Kaneki M, Martyn JA. Nonsurgically induced disuse muscle atrophy and neuromuscular dysfunction upregulates alpha7 acetylcholine receptors. Can J Physiol Pharmacol. 2014 Jan; 92(1):1-8. PMID: 24383867.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Zhu S, Nagashima M, Khan MA, Yasuhara S, Kaneki M, Martyn JA. Lack of caspase-3 attenuates immobilization-induced muscle atrophy and loss of tension generation along with mitigation of apoptosis and inflammation. Muscle Nerve. 2013 May; 47(5):711-21. PMID: 23401051.
    Citations: 17     Fields:    Translation:Animals
  10. Mohammed Abdul Sattar Khan, Mina Farkhondeh, Jennifer Crombie, Leslie Jacobson, Masao Kaneki and Jeevendra A. J. Martyn. Lipopolysaccharide Up-regulates Neuronal Alpha7 Acetylcholine Receptors: Stimulation with GTS-21 Mitigates Growth Arrest of Macrophages and Improves Survival in Burned Mice. Shock. 2012; 38(2):213-219. View Publication.
  11. Khan MA, Farkhondeh M, Crombie J, Jacobson L, Kaneki M, Martyn JA. Lipopolysaccharide upregulates a7 acetylcholine receptors: stimulation with GTS-21 mitigates growth arrest of macrophages and improves survival in burned mice. Shock. 2012 Aug; 38(2):213-9. PMID: 22683726.
    Citations: 23     Fields:    Translation:AnimalsCells
  12. Mohammed Abdul Sattar Khan, Mohammed Akbar, Motomitsu Kitaoka and Kiyoshi Hayashi. A unique Thermostable Lichenase from Thermotoga maritime MSB8 with Divergent Sbustrate Specificity. Indian Journal of Biotechnology,. 2007; 6(3):315-320. View Publication.
  13. Mohammed Abdul Sattar Khan, P. Boon Chock and Earl R. Stadtman. Knockout of Caspase-Like Gene, YCA1, Abrogates Apoptosis and Elevates Oxidized Proteins in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 2005; 102(48):17326-17331. View Publication.
  14. Mohammed Abdul Sattar Khan, Hammou Oubrahim and Earl R. Stadtman. Inhibition of Apoptosis in Acute Promyelocytic Leukemia Cells Leads to Increases in Levels of Oxidized Protein and LMP2 Immunoproteasome. Proc. Natl. Acad. Sci. USA. 2004; 101(32):11560-11565. View Publication.
  15. Mohammed Abdul Sattar Khan, Soichiro Nakamura, Masahiro Ogawa, Emmanuel Akita, Hiroyuki Azakami and Akio Kato. Bactericidal Action of Egg yolk Phosvitin against Escherichia coli under Thermal Stress. J. Agric. Food Chem. 2000; 48(5):1503-1506. View Publication.
  16. Mohammed Abdul Sattar Khan, El fadil E. Babiker, Hiroyuki Azakami and Akio Kato. Molecular Mechanism of the Excellent Emulsifying Properties of Phosvitin-Galactomannan Conjugate. J. Agric. Food Chem. 1999; 47(6): 2262-2266. View Publication.
  17. Mohammed Abdul Sattar Khan, El fadil E. Babiker, Hiroyuki Azakami and Akio Kato. Effect of Protease Digestion and Dephosphorylation on High Emulsifying Properties of Hen Egg Yolk Phosvitin. J. Agric. Food Chem. 1998; 48(12):4977-4981. View Publication.
  18. El fadil E. Babiker, Mohammed Abdul Sattar Khan, Naotoshi Matsudomi and Akio Kato. . Polymerization of Soy Protein Digests by Microbial Transglutaminase for Improvement of the Functional Properties. Food Res. Intrl.. 1996; 29(7):627-634.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.