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profileElizabeth M. Bradshaw, Ph.D.

TitleAssistant Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressBrigham and Women's Hospital
Neurology - NRB 641
75 Francis St
Boston MA 02115
Phone617/732-5500
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS089674     (BRADSHAW, ELIZABETH M)Sep 1, 2015 - Jun 30, 2019
NIH/NINDS
Influence of genotype on microglia phenotype and function in PD
Role: Principal Investigator

R56NS089674     (BRADSHAW, ELIZABETH M)Sep 30, 2014 - Aug 31, 2015
NIH/NINDS
Influence of genotype on monocyte and microglia phenotype and function in Parkinson's disease (PD)
Role: Principal Investigator

R01AG043617     (BRADSHAW, ELIZABETH M)Sep 30, 2012 - Apr 30, 2017
NIH/NIA
Altered monocyte function in relation to the CD33 Alzheimers disease locus
Role: Principal Investigator

F32AI065100     (BRADSHAW, ELIZABETH M)Apr 1, 2006 - Mar 31, 2009
NIH/NIAID
Characterization of B Cells in Dermatomyositis
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Faridi MH, Khan SQ, Zhao W, Lee HW, Altintas MM, Zhang K, Kumar V, Armstrong AR, Carmona-Rivera C, Dorschner JM, Schnaith AM, Li X, Ghodke-Puranik Y, Moore E, Purmalek M, Irizarry-Caro J, Zhang T, Day R, Stoub D, Hoffmann V, Khaliqdina SJ, Bhargava P, Santander AM, Torroella-Kouri M, Issac B, Cimbaluk DJ, Zloza A, Prabhakar R, Deep S, Jolly M, Koh KH, Reichner JS, Bradshaw EM, Chen J, Moita LF, Yuen PS, Li Tsai W, Singh B, Reiser J, Nath SK, Niewold TB, Vazquez-Padron RI, Kaplan MJ, Gupta V. CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus. J Clin Invest. 2017 Apr 03; 127(4):1271-1283. PMID: 28263189.
    View in: PubMed
  2. Kurdi AT, Bassil R, Olah M, Wu C, Xiao S, Taga M, Frangieh M, Buttrick T, Orent W, Bradshaw EM, Khoury SJ, Elyaman W. Tiam1/Rac1 complex controls Il17a transcription and autoimmunity. Nat Commun. 2016 Oct 11; 7:13048. PMID: 27725632.
    View in: PubMed
  3. Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, De Jager PL, Bradshaw EM. Trans-pQTL study identifies immune crosstalk between Parkinson and Alzheimer loci. Neurol Genet. 2016 Aug; 2(4):e90. PMID: 27504496; PMCID: PMC4962525.
  4. Orent W, Mchenry AR, Rao DA, White C, Klein HU, Bassil R, Srivastava G, Replogle JM, Raj T, Frangieh M, Cimpean M, Cuerdon N, Chibnik L, Khoury SJ, Karlson EW, Brenner MB, De Jager P, Bradshaw EM, Elyaman W. Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells. Hum Mol Genet. 2016 Jan 15; 25(2):404-17. PMID: 26604133; PMCID: PMC4881829 [Available on 01/15/17].
  5. Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, Bennett DA, Chibnik LB, Sperling RA, Bradshaw EM, De Jager PL. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci. 2015 Nov; 18(11):1556-8. PMID: 26414614; PMCID: PMC4682915.
  6. Du Z, Abedalthagafi M, Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O, Machaidze R, Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, Santagata S. Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma. Oncotarget. 2015 Mar 10; 6(7):4704-16. PMID: 25609200; PMCID: PMC4467109.
  7. Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Ann Neurol. 2015 Mar; 77(3):469-77. PMID: 25545807; PMCID: PMC4461024.
  8. Adegbola AA, Cox GF, Bradshaw EM, Hafler DA, Gimelbrant A, Chess A. Monoallelic expression of the human FOXP2 speech gene. Proc Natl Acad Sci U S A. 2015 Jun 02; 112(22):6848-54. PMID: 25422445; PMCID: PMC4460484.
  9. Raj T, Ryan KJ, Replogle JM, Chibnik LB, Rosenkrantz L, Tang A, Rothamel K, Stranger BE, Bennett DA, Evans DA, De Jager PL, Bradshaw EM. CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility. Hum Mol Genet. 2014 May 15; 23(10):2729-36. PMID: 24381305; PMCID: PMC3990171.
  10. Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, Tang A, Rosenkrantz LL, Imboywa S, Lee M, Von Korff A, Morris MC, Evans DA, Johnson K, Sperling RA, Schneider JA, Bennett DA, De Jager PL. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci. 2013 Jul; 16(7):848-50. PMID: 23708142; PMCID: PMC3703870.
  11. Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. PLoS One. 2012; 7(10):e46709. PMID: 23071619; PMCID: PMC3465259.
  12. Elyaman W, Bassil R, Bradshaw EM, Orent W, Lahoud Y, Zhu B, Radtke F, Yagita H, Khoury SJ. Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity. 2012 Apr 20; 36(4):623-34. PMID: 22503540; PMCID: PMC3572366.
  13. Han Q, Bagheri N, Bradshaw EM, Hafler DA, Lauffenburger DA, Love JC. Polyfunctional responses by human T cells result from sequential release of cytokines. Proc Natl Acad Sci U S A. 2012 Jan 31; 109(5):1607-12. PMID: 22160692; PMCID: PMC3277116.
  14. Raddassi K, Kent SC, Yang J, Bourcier K, Bradshaw EM, Seyfert-Margolis V, Nepom GT, Kwok WW, Hafler DA. Increased frequencies of myelin oligodendrocyte glycoprotein/MHC class II-binding CD4 cells in patients with multiple sclerosis. J Immunol. 2011 Jul 15; 187(2):1039-46. PMID: 21653833; PMCID: PMC3131477.
  15. Beriou G, Bradshaw EM, Lozano E, Costantino CM, Hastings WD, Orban T, Elyaman W, Khoury SJ, Kuchroo VK, Baecher-Allan C, Hafler DA. TGF-beta induces IL-9 production from human Th17 cells. J Immunol. 2010 Jul 01; 185(1):46-54. PMID: 20498357; PMCID: PMC2936106.
  16. Han Q, Bradshaw EM, Nilsson B, Hafler DA, Love JC. Multidimensional analysis of the frequencies and rates of cytokine secretion from single cells by quantitative microengraving. Lab Chip. 2010 Jun 07; 10(11):1391-400. PMID: 20376398; PMCID: PMC3128808.
  17. Song Q, Han Q, Bradshaw EM, Kent SC, Raddassi K, Nilsson B, Nepom GT, Hafler DA, Love JC. On-chip activation and subsequent detection of individual antigen-specific T cells. Anal Chem. 2010 Jan 15; 82(2):473-7. PMID: 20000848; PMCID: PMC2828941.
  18. Bradshaw EM, Raddassi K, Elyaman W, Orban T, Gottlieb PA, Kent SC, Hafler DA. Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol. 2009 Oct 01; 183(7):4432-9. PMID: 19748982; PMCID: PMC2770506.
  19. Elyaman W, Bradshaw EM, Uyttenhove C, Dardalhon V, Awasthi A, Imitola J, Bettelli E, Oukka M, van Snick J, Renauld JC, Kuchroo VK, Khoury SJ. IL-9 induces differentiation of TH17 cells and enhances function of FoxP3+ natural regulatory T cells. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12885-90. PMID: 19433802; PMCID: PMC2722314.
  20. Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clin Immunol. 2008 Oct; 129(1):10-8. PMID: 18675591; PMCID: PMC2577144.
  21. Elyaman W, Kivisäkk P, Reddy J, Chitnis T, Raddassi K, Imitola J, Bradshaw E, Kuchroo VK, Yagita H, Sayegh MH, Khoury SJ. Distinct functions of autoreactive memory and effector CD4+ T cells in experimental autoimmune encephalomyelitis. Am J Pathol. 2008 Aug; 173(2):411-22. PMID: 18583313; PMCID: PMC2475778.
  22. Elyaman W, Bradshaw E, Zhu B, Trenado A, Liu YR, Yagita H, Khoury S. Non-redundant roles of Jagged1 and Jagged2 in regulating experimental autoimmune encephalonnyelitis. CLINICAL IMMUNOLOGY. 2008; 127(Suppl. S ):S51-S51.
  23. Bradshaw E, Kent S, Greer A, Elyaman W, Raddassi K , Love JC, Orban T, Hafler D. Ex vivo activated state of type 1 diabetic monocytes. CLINICAL IMMUNOLOGY. 2008; 127 (Suppl. S):S106-S106.
  24. Elyaman W, Bradshaw EM, Wang Y, Oukka M, Kivisäkk P, Chiba S, Yagita H, Khoury SJ. JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J Immunol. 2007 Nov 01; 179(9):5990-8. PMID: 17947672.
    View in: PubMed
  25. Bradshaw EM, Orihuela A, McArdel SL, Salajegheh M, Amato AA, Hafler DA, Greenberg SA, O'Connor KC. A local antigen-driven humoral response is present in the inflammatory myopathies. J Immunol. 2007 Jan 01; 178(1):547-56. PMID: 17182595.
    View in: PubMed
  26. Bradshaw E, Orihuela A, McArdel S, Hafler D, Amato A, O'Connor K. Characterization of single B cell immunoglobulin variable region genes derived from infiltrated muscle tissue of subjects with inflammatory myopathies. CLINICAL IMMUNOLOGY. 2007; 123 (Suppl. S):S152-S152.
  27. O'Connor K, McArdel S, Bradshaw E, Anderson D, Moore N, Brady M, Hafler D. Examination of the B-cell repertoire in the CNS of patients with MS. CLINICAL IMMUNOLOGY. 2006; 119(Suppl. S):S108-S108.
  28. Elyaman W, Bradshaw E, Wang Y, Kivissak P, Oukka M, Yagita H, Sayegh M, Khoury S. Notch signaling regulates experimental autoimmune encephalomyelitis: Crosstalk between autoreactive T-cells and astrocytes. CLINICAL IMMUNOLOGY. 2006; 119(Suppl. S):S38-S38.
  29. Bradshaw E, Orihuela A, Amato A, Hafler D, Greenberg S, O'Connor K. Characterization of B-cell immunoglobulin variable region genes derived from muscle tissue of subjects with inflammatory myopathies. CLINICAL IMMUNOLOGY. 2006; 119(Suppl. S):S115-S115 .
  30. Greenberg SA, Bradshaw EM, Pinkus JL, Pinkus GS, Burleson T, Due B, Bregoli L, Bregoli LS, O'Connor KC, Amato AA. Plasma cells in muscle in inclusion body myositis and polymyositis. Neurology. 2005 Dec 13; 65(11):1782-7. PMID: 16344523.
    View in: PubMed
  31. Elizabeth Bradshaw, PhD. New Technique for Studying Homogeneous Neuronal Cell Populations. Journal Watch Neurology (Martin A. Samuels). 2005.
  32. O'Connor KC, Moore NH, Bregoli L, Bradshaw E, Wucherpfennig K, Hafler DA. Characterization of B cell immunoglobulin variable region genes derived from lesions of patients with MS. CLINICAL IMMUNOLOGY. 2005; 115 (Suppl. 1 ):S102-S102.
  33. Bradshaw EM, Sanford DG, Luo X, Sudmeier JL, Gurard-Levin ZA, Bullock PA, Bachovchin WW. T antigen origin-binding domain of simian virus 40: determinants of specific DNA binding. Biochemistry. 2004 Jun 08; 43(22):6928-36. PMID: 15170330.
    View in: PubMed
  34. Elizabeth M. Bradshaw. Interactions of the Origin DNA-Binding Domain of SV40 T Antigen with DNA . 2004.
  35. Sudmeier JL, Bradshaw EM, Haddad KE, Day RM, Thalhauser CJ, Bullock PA, Bachovchin WW. Identification of histidine tautomers in proteins by 2D 1H/13C(delta2) one-bond correlated NMR. J Am Chem Soc. 2003 Jul 16; 125(28):8430-1. PMID: 12848537.
    View in: PubMed
  36. Bradshaw E, Luo XL, Sanford DG, Sudmeier J, Bullock PA, Bachovchin WW. Structural investigations of SV40 T-antigen DNA-binding domain interacting with DNA. BIOCHEMISTRY. 2001; 40(29):8645-8645.
  37. Ash EL, Sudmeier JL, Day RM, Vincent M, Torchilin EV, Haddad KC, Bradshaw EM, Sanford DG, Bachovchin WW. Unusual 1H NMR chemical shifts support (His) C(epsilon) 1...O==C H-bond: proposal for reaction-driven ring flip mechanism in serine protease catalysis. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10371-6. PMID: 10984533; PMCID: PMC27031.
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