Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Kristopher Thomas Kahle, M.D.,Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01NS117609 (KAHLE, KRISTOPHER) Jul 15, 2020 - Jun 30, 2026
    NIH
    Human genetics and molecular mechanisms of Vein of Galen aneurysmal malformation
    Role: Principal Investigator
  2. R01NS111029 (KAHLE, KRISTOPHER) Feb 1, 2020 - Jan 31, 2025
    NIH
    Human genetics and molecular mechanisms of congenital hydrocephalus
    Role: Principal Investigator
  3. R01NS109358 (KAHLE, KRISTOPHER) Sep 1, 2018 - Jul 31, 2023
    NIH
    Modulation of choroid plexus immuno-secretory function to restore cerebrospinal fluid homeostasis in hydrocephalus
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bramall AN, Anton ES, Kahle KT, Fecci PE. Navigating the ventricles: Novel insights into the pathogenesis of hydrocephalus. EBioMedicine. 2022 Mar 16; 78:103931. PMID: 35306341.
    Citations:    Fields:    
  2. Bhuiyan MIH, Young CB, Jahan I, Hasan MN, Fischer S, Meor Azlan NF, Liu M, Chattopadhyay A, Huang H, Kahle KT, Zhang J, Poloyac SM, Molyneaux BJ, Straub AC, Deng X, Gomez D, Sun D. NF-?B Signaling-Mediated Activation of WNK-SPAK-NKCC1 Cascade in Worsened Stroke Outcomes of Ang II-Hypertensive Mice. Stroke. 2022 Mar 11; STROKEAHA121038351. PMID: 35272484.
    Citations:    Fields:    
  3. Xue Y, Gursky Z, Monte B, Koundal S, Liu X, Lee H, Michurina TV, Mellanson KA, Zhao L, Nemajerova A, Kahle KT, Takemaru KI, Enikolopov G, Peunova NI, Benveniste H. Sustained glymphatic transport and impaired drainage to the nasal cavity observed in multiciliated cell ciliopathies with hydrocephalus. Fluids Barriers CNS. 2022 Mar 05; 19(1):20. PMID: 35248089.
    Citations:    Fields:    
  4. Wang YC, Wu Y, Choi J, Allington G, Zhao S, Khanfar M, Yang K, Fu PY, Wrubel M, Yu X, Mekbib KY, Ocken J, Smith H, Shohfi J, Kahle KT, Lu Q, Jin SC. Computational Genomics in the Era of Precision Medicine: Applications to Variant Analysis and Gene Therapy. J Pers Med. 2022 Jan 27; 12(2). PMID: 35207663.
    Citations:    
  5. Duy PQ, Rakic P, Alper SL, Butler WE, Walsh CA, Sestan N, Geschwind DH, Jin SC, Kahle KT. Brain ventricles as windows into brain development and disease. Neuron. 2022 01 05; 110(1):12-15. PMID: 34990576.
    Citations: 1     Fields:    
  6. Barak T, Ristori E, Ercan-Sencicek AG, Miyagishima DF, Nelson-Williams C, Dong W, Jin SC, Prendergast A, Armero W, Henegariu O, Erson-Omay EZ, Harmanci AS, Guy M, Gültekin B, Kilic D, Rai DK, Goc N, Aguilera SM, Gülez B, Altinok S, Ozcan K, Yarman Y, Coskun S, Sempou E, Deniz E, Hintzen J, Cox A, Fomchenko E, Jung SW, Ozturk AK, Louvi A, Bilgüvar K, Connolly ES, Khokha MK, Kahle KT, Yasuno K, Lifton RP, Mishra-Gorur K, Nicoli S, Günel M. PPIL4 is essential for brain angiogenesis and implicated in intracranial aneurysms in humans. Nat Med. 2021 12; 27(12):2165-2175. PMID: 34887573.
    Citations:    Fields:    Translation:HumansCells
  7. Qi C, Feng I, Costa AR, Pinto-Costa R, Neil JE, Caluseriu O, Li D, Ganetzky RD, Brasch-Andersen C, Fagerberg C, Hansen LK, Bupp C, Muraresku CC, Ruan X, Kang B, Hu K, Zhong R, Brites P, Bhoj EJ, Hill RS, Falk MJ, Hakonarson H, Kahle KT, Sousa MM, Walsh CA, Zhang X. Variants in ADD1 cause intellectual disability, corpus callosum dysgenesis, and ventriculomegaly in humans. Genet Med. 2022 02; 24(2):319-331. PMID: 34906466.
    Citations:    Fields:    
  8. Allington G, Duy PQ, Ryou J, Singh A, Kiziltug E, Robert SM, Kundishora AJ, King S, Haider S, Kahle KT, Jin SC. Genomic approaches to improve the clinical diagnosis and management of patients with congenital hydrocephalus. J Neurosurg Pediatr. 2021 Oct 29; 1-10. PMID: 34715668.
    Citations:    Fields:    
  9. Dinis J, Junn A, Kahle K, Alperovich M. Extended Scalp Expansion for Larger Defects During Staged Cranioplasty. J Craniofac Surg. 2021 Oct 29. PMID: 34723917.
    Citations:    Fields:    
  10. DeSpenza T, Carlson M, Panchagnula S, Robert S, Duy PQ, Mermin-Bunnell N, Reeves BC, Kundishora A, Elsamadicy AA, Smith H, Ocken J, Alper SL, Jin SC, Hoffman EJ, Kahle KT. PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets. Trends Neurosci. 2021 12; 44(12):961-976. PMID: 34625286.
    Citations:    Fields:    
  11. Junn A, Dinis J, Kahle KT, Alperovich M. Stepwise Reconstruction of a Large, Self-Inflicted Calvarial Defect. J Craniofac Surg. 2021 Sep 22. PMID: 34560747.
    Citations:    Fields:    
  12. Kundishora AJ, Peters ST, Pinard A, Duran D, Panchagnula S, Barak T, Miyagishima DF, Dong W, Smith H, Ocken J, Dunbar A, Nelson-Williams C, Haider S, Walker RL, Li B, Zhao H, Thumkeo D, Marlier A, Duy PQ, Diab NS, Reeves BC, Robert SM, Sujijantarat N, Stratman AN, Chen YH, Zhao S, Roszko I, Lu Q, Zhang B, Mane S, Castaldi C, López-Giráldez F, Knight JR, Bamshad MJ, Nickerson DA, Geschwind DH, Chen SL, Storm PB, Diluna ML, Matouk CC, Orbach DB, Alper SL, Smith ER, Lifton RP, Gunel M, Milewicz DM, Jin SC, Kahle KT. DIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease. JAMA Neurol. 2021 08 01; 78(8):993-1003. PMID: 34125151.
    Citations: 2     Fields:    Translation:Humans
  13. Puthenpura V, DeNunzio NJ, Zeng X, Giantsoudi D, Aboian M, Ebb D, Kahle KT, Yock TI, Marks AM. Radiation Necrosis with Proton Therapy in a Patient with Aarskog-Scott Syndrome and Medulloblastoma. Int J Part Ther. 2022; 8(3):58-65. PMID: 35127977.
    Citations:    
  14. Kundishora AJ, Singh AK, Allington G, Duy PQ, Ryou J, Alper SL, Jin SC, Kahle KT. Genomics of human congenital hydrocephalus. Childs Nerv Syst. 2021 11; 37(11):3325-3340. PMID: 34232380.
    Citations: 1     Fields:    Translation:Humans
  15. Diab NS, Barish S, Dong W, Zhao S, Allington G, Yu X, Kahle KT, Brueckner M, Jin SC. Molecular Genetics and Complex Inheritance of Congenital Heart Disease. Genes (Basel). 2021 06 30; 12(7). PMID: 34209044.
    Citations: 1     Fields:    Translation:Humans
  16. Robert SM, Reeves BC, Marlier A, Duy PQ, DeSpenza T, Kundishora A, Kiziltug E, Singh A, Allington G, Alper SL, Kahle KT. Inflammatory hydrocephalus. Childs Nerv Syst. 2021 11; 37(11):3341-3353. PMID: 34164718.
    Citations: 1     Fields:    Translation:Humans
  17. Omer S, Jin SC, Koumangoye R, Robert SM, Duran D, Nelson-Williams C, Huttner A, DiLuna M, Kahle KT, Delpire E. Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination. Clin Genet. 2021 08; 100(2):176-186. PMID: 33904160.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Duy PQ, Kahle KT. Intraventricular CSF Turbulence in Pediatric Communicating Hydrocephalus. Neurology. 2021 08 03; 97(5):246-247. PMID: 34031199.
    Citations:    Fields:    Translation:Humans
  19. Elsamadicy AA, Koo AB, David WB, Freedman IG, Kundishora AJ, Hong CS, Sarkozy M, Sciubba DM, Kahle KT, DiLuna M. Impact of race on outcomes and healthcare utilization following spinal fusion for adolescent idiopathic scoliosis. Clin Neurol Neurosurg. 2021 Jul; 206:106634. PMID: 33979695.
    Citations:    Fields:    Translation:Humans
  20. Rahmati N, Normoyle KP, Glykys J, Dzhala VI, Lillis KP, Kahle KT, Raiyyani R, Jacob T, Staley KJ. Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains. J Neurosci. 2021 06 09; 41(23):4957-4975. PMID: 33903223.
    Citations:    Fields:    Translation:AnimalsCells
  21. Koo AB, Elsamadicy AA, Lin IH, David WB, Reeves BC, Santarosa C, Cord B, Malhotra A, Kahle KT, Matouk CC. Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study. World Neurosurg. 2021 08; 152:e23-e31. PMID: 33862298.
    Citations:    Fields:    Translation:Humans
  22. Diab NS, King S, Dong W, Allington G, Sheth A, Peters ST, Kahle KT, Jin SC. Analysis workflow to assess de novo genetic variants from human whole-exome sequencing. STAR Protoc. 2021 03 19; 2(1):100383. PMID: 33748785.
    Citations:    Fields:    
  23. Sullivan W, Reeves BC, Duy PQ, Nelson-Williams C, Dong W, Jin SC, Kahle KT. Exome Sequencing as a Potential Diagnostic Adjunct in Sporadic Congenital Hydrocephalus. JAMA Pediatr. 2021 03 01; 175(3):310-313. PMID: 33196764.
    Citations: 1     Fields:    Translation:Humans
  24. Elsamadicy AA, Koo AB, David WB, Lee V, Zogg CK, Kundishora AJ, Hong C, Reeves BC, Sarkozy M, Kahle KT, DiLuna M. Post-traumatic seizures following pediatric traumatic brain injury. Clin Neurol Neurosurg. 2021 Apr; 203:106556. PMID: 33636505.
    Citations:    Fields:    Translation:Humans
  25. Elsamadicy AA, Freedman IG, Koo AB, David WB, Havlik J, Kundishora AJ, Sciubba DM, Kahle KT, DiLuna M. The Effects of Pulmonary Risk Factors on Hospital Resource Use After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis Correction. World Neurosurg. 2021 05; 149:e737-e747. PMID: 33548534.
    Citations:    Fields:    Translation:Humans
  26. Fomchenko EI, Reeves BC, Sullivan W, Marks AM, Huttner A, Kahle KT, Erson-Omay EZ. Dual activating FGFR1 mutations in pediatric pilomyxoid astrocytoma. Mol Genet Genomic Med. 2021 02; 9(2):e1597. PMID: 33448156.
    Citations:    Fields:    Translation:Humans
  27. Dur AH, Tang T, Viviano S, Sekuri A, Willsey HR, Tagare HD, Kahle KT, Deniz E. In Xenopus ependymal cilia drive embryonic CSF circulation and brain development independently of cardiac pulsatile forces. Fluids Barriers CNS. 2020 Dec 11; 17(1):72. PMID: 33308296.
    Citations: 4     Fields:    Translation:AnimalsCells
  28. Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, Knight JR, Sullivan W, Duy PQ, DeSpenza T, Reeves BC, Karimy JK, Marlier A, Castaldi C, Tikhonova IR, Li B, Peña HP, Broach JR, Kabachelor EM, Ssenyonga P, Hehnly C, Ge L, Keren B, Timberlake AT, Goto J, Mangano FT, Johnston JM, Butler WE, Warf BC, Smith ER, Schiff SJ, Limbrick DD, Heuer G, Jackson EM, Iskandar BJ, Mane S, Haider S, Guclu B, Bayri Y, Sahin Y, Duncan CC, Apuzzo MLJ, DiLuna ML, Hoffman EJ, Sestan N, Ment LR, Alper SL, Bilguvar K, Geschwind DH, Günel M, Lifton RP, Kahle KT. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nat Med. 2020 11; 26(11):1754-1765. PMID: 33077954.
    Citations: 11     Fields:    Translation:HumansCells
  29. Elsamadicy AA, Freedman IG, Koo AB, David WB, Havlik J, Kundishora AJ, Hong CS, Sciubba DM, Kahle KT, DiLuna M. Impact of Preoperative Anemia on Outcomes After Posterior Spinal Fusion for Adolescent Idiopathic Scoliosis. World Neurosurg. 2021 02; 146:e214-e224. PMID: 33091648.
    Citations:    Fields:    Translation:Humans
  30. Robert SM, Reeves BC, Alper SL, Zhang J, Kahle KT. New drugs on the horizon for cerebral edema: what's in the clinical development pipeline? Expert Opin Investig Drugs. 2020 Oct; 29(10):1099-1105. PMID: 32815401.
    Citations: 2     Fields:    Translation:HumansAnimals
  31. Dong W, Jin SC, Allocco A, Zeng X, Sheth AH, Panchagnula S, Castonguay A, Lorenzo LÉ, Islam B, Brindle G, Bachand K, Hu J, Sularz A, Gaillard J, Choi J, Dunbar A, Nelson-Williams C, Kiziltug E, Furey CG, Conine S, Duy PQ, Kundishora AJ, Loring E, Li B, Lu Q, Zhou G, Liu W, Li X, Sierant MC, Mane S, Castaldi C, López-Giráldez F, Knight JR, Sekula RF, Simard JM, Eskandar EN, Gottschalk C, Moliterno J, Günel M, Gerrard JL, Dib-Hajj S, Waxman SG, Barker FG, Alper SL, Chahine M, Haider S, De Koninck Y, Lifton RP, Kahle KT. Exome Sequencing Implicates Impaired GABA Signaling and Neuronal Ion Transport in Trigeminal Neuralgia. iScience. 2020 Oct 23; 23(10):101552. PMID: 33083721.
    Citations: 3     
  32. Koo AB, Yeung JT, Freedman IG, Lee JH, Ahmed OM, Ma AK, Miyagishima DF, DiLuna M, Kahle K. Clinical and economic burden of neurofibromatosis type 2 in the United States. Clin Neurol Neurosurg. 2020 10; 197:106053. PMID: 32683193.
    Citations:    Fields:    Translation:Humans
  33. Elsamadicy AA, Koo AB, David WB, Kundishora AJ, Hong CS, Sarkozy M, Kahle KT, DiLuna M. Pre-operative headaches and obstructive hydrocephalus predict an extended length of stay following suboccipital decompression for pediatric Chiari I malformation. Childs Nerv Syst. 2021 01; 37(1):91-99. PMID: 32519127.
    Citations:    Fields:    Translation:Humans
  34. Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent STAG2 mutation despite multimodal therapy in recurrent pediatric glioblastoma. NPJ Genom Med. 2020; 5:23. PMID: 32528726.
    Citations: 1     
  35. Elsamadicy AA, Koo AB, Lee V, David WB, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeve BC, DiLuna M, Kahle KT. Risk Factors for the Development of Post-Traumatic Hydrocephalus in Children. World Neurosurg. 2020 09; 141:e105-e111. PMID: 32389871.
    Citations:    Fields:    Translation:Humans
  36. Duy PQ, He M, He Z, Kahle KT. Preclinical insights into therapeutic targeting of KCC2 for disorders of neuronal hyperexcitability. Expert Opin Ther Targets. 2020 07; 24(7):629-637. PMID: 32336175.
    Citations:    Fields:    Translation:HumansAnimalsCells
  37. Karimy JK, Reeves BC, Kahle KT. Targeting TLR4-dependent inflammation in post-hemorrhagic brain injury. Expert Opin Ther Targets. 2020 06; 24(6):525-533. PMID: 32249624.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  38. Karimy JK, Reeves BC, Damisah E, Duy PQ, Antwi P, David W, Wang K, Schiff SJ, Limbrick DD, Alper SL, Warf BC, Nedergaard M, Simard JM, Kahle KT. Inflammation in acquired hydrocephalus: pathogenic mechanisms and therapeutic targets. Nat Rev Neurol. 2020 05; 16(5):285-296. PMID: 32152460.
    Citations: 23     Fields:    Translation:HumansAnimals
  39. Elsamadicy AA, Koo AB, Lee M, David WB, Kundishora AJ, Freedman IG, Zogg CK, Hong CS, DeSpenza T, Sarkozy M, Kahle KT, DiLuna M. Risk Factors Portending Extended Length of Stay After Suboccipital Decompression for Adult Chiari I Malformation. World Neurosurg. 2020 06; 138:e515-e522. PMID: 32147550.
    Citations:    Fields:    Translation:Humans
  40. Elsamadicy AA, Koo AB, David WB, Lee V, Zogg CK, Kundishora AJ, Hong CS, DeSpenza T, Reeves BC, Kahle KT, DiLuna M. Comparison of epidemiology, treatments, and outcomes in pediatric versus adult ependymoma. Neurooncol Adv. 2020 Jan-Dec; 2(1):vdaa019. PMID: 32642681.
    Citations: 4     
  41. Date P, Ackermann P, Furey C, Fink IB, Jonas S, Khokha MK, Kahle KT, Deniz E. Author Correction: Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus. Sci Rep. 2020 Feb 12; 10(1):2791. PMID: 32047215.
    Citations:    Fields:    
  42. Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, Alper SL, Lundgaard I, Nedergaard M, Kahle KT. Glymphatic System Impairment in Alzheimer's Disease and Idiopathic Normal Pressure Hydrocephalus. Trends Mol Med. 2020 03; 26(3):285-295. PMID: 31959516.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  43. Kundishora AJ, Reeves BC, Nelson-Williams C, Hong CS, Gopal PP, Snuderl M, Kahle KT, Erson-Omay EZ. Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm. Clin Genet. 2020 05; 97(5):791-792. PMID: 31925773.
    Citations: 4     Fields:    Translation:Humans
  44. Koo AB, Elsamadicy AA, Kundishora AJ, David WB, Lee M, Hong CS, Lee V, Kahle KT, DiLuna M. Geographic Variation in Outcomes and Costs After Spinal Fusion for Adolescent Idiopathic Scoliosis. World Neurosurg. 2020 Apr; 136:e347-e354. PMID: 31917315.
    Citations: 2     Fields:    Translation:Humans
  45. Zhang J, Bhuiyan MIH, Zhang T, Karimy JK, Wu Z, Fiesler VM, Zhang J, Huang H, Hasan MN, Skrzypiec AE, Mucha M, Duran D, Huang W, Pawlak R, Foley LM, Hitchens TK, Minnigh MB, Poloyac SM, Alper SL, Molyneaux BJ, Trevelyan AJ, Kahle KT, Sun D, Deng X. Modulation of brain cation-Cl- cotransport via the SPAK kinase inhibitor ZT-1a. Nat Commun. 2020 01 07; 11(1):78. PMID: 31911626.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  46. Duy PQ, David WB, Kahle KT. Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation. Front Cell Neurosci. 2019; 13:515. PMID: 31803025.
    Citations: 10     
  47. Fomchenko EI, Erson-Omay EZ, Kundishora AJ, Hong CS, Daniel AA, Allocco A, Duy PQ, Darbinyan A, Marks AM, DiLuna ML, Kahle KT, Huttner A. Genomic alterations underlying spinal metastases in pediatric H3K27M-mutant pineal parenchymal tumor of intermediate differentiation: case report. J Neurosurg Pediatr. 2019 Oct 25; 1-10. PMID: 31653819.
    Citations: 3     Fields:    
  48. Watanabe M, Zhang J, Mansuri MS, Duan J, Karimy JK, Delpire E, Alper SL, Lifton RP, Fukuda A, Kahle KT. Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival. Sci Signal. 2019 10 15; 12(603). PMID: 31615901.
    Citations: 20     Fields:    Translation:AnimalsCells
  49. Pisella LI, Gaiarsa JL, Diabira D, Zhang J, Khalilov I, Duan J, Kahle KT, Medina I. Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology. Sci Signal. 2019 10 15; 12(603). PMID: 31615899.
    Citations: 17     Fields:    Translation:AnimalsCells
  50. Allocco AA, Jin SC, Duy PQ, Furey CG, Zeng X, Dong W, Nelson-Williams C, Karimy JK, DeSpenza T, Hao LT, Reeves B, Haider S, Gunel M, Lifton RP, Kahle KT. Recessive Inheritance of Congenital Hydrocephalus With Other Structural Brain Abnormalities Caused by Compound Heterozygous Mutations in ATP1A3. Front Cell Neurosci. 2019; 13:425. PMID: 31616254.
    Citations: 4     
  51. Elsamadicy AA, Koo AB, Lee M, Kundishora AJ, Hong CS, Hengartner AC, Camara-Quintana J, Kahle KT, DiLuna ML. Reduced influence of affective disorders on perioperative complication rates, length of hospital stay, and healthcare costs following spinal fusion for adolescent idiopathic scoliosis. J Neurosurg Pediatr. 2019 Sep 06; 1-6. PMID: 31491756.
    Citations:    Fields:    
  52. Lanni JS, Peal D, Ekstrom L, Chen H, Stanclift C, Bowen ME, Mercado A, Gamba G, Kahle KT, Harris MP. Integrated K+ channel and K+Cl- cotransporter functions are required for the coordination of size and proportion during development. Dev Biol. 2019 12 15; 456(2):164-178. PMID: 31472116.
    Citations: 9     Fields:    Translation:AnimalsCells
  53. Hong CS, Kundishora AJ, Kahle KT, Diluna ML. Teaching NeuroImages: Unilateral focal segmental hyperhidrosis from spinal tumor progression. Neurology. 2019 08 13; 93(7):e729-e730. PMID: 31405944.
    Citations:    Fields:    Translation:Humans
  54. Jin SC, Furey CG, Zeng X, Allocco A, Nelson-Williams C, Dong W, Karimy JK, Wang K, Ma S, Delpire E, Kahle KT. SLC12A ion transporter mutations in sporadic and familial human congenital hydrocephalus. Mol Genet Genomic Med. 2019 09; 7(9):e892. PMID: 31393094.
    Citations: 10     Fields:    Translation:HumansAnimalsCTClinical Trials
  55. Elsamadicy AA, Koo AB, Kundishora AJ, Chouairi F, Lee M, Hengartner AC, Camara-Quintana J, Kahle KT, DiLuna ML. Impact of patient and hospital-level risk factors on extended length of stay following spinal fusion for adolescent idiopathic scoliosis. J Neurosurg Pediatr. 2019 Aug 02; 1-7. PMID: 31374544.
    Citations: 4     Fields:    
  56. Hong CS, Camara-Quintana J, Kundishora AJ, Diluna ML, Kahle KT. Teaching NeuroImages: Spinal subdural hematoma in pediatric nonaccidental trauma. Neurology. 2019 07 30; 93(5):e522-e523. PMID: 31358679.
    Citations: 1     Fields:    Translation:Humans
  57. Lalioti ME, Kaplani K, Lokka G, Georgomanolis T, Kyrousi C, Dong W, Dunbar A, Parlapani E, Damianidou E, Spassky N, Kahle KT, Papantonis A, Lygerou Z, Taraviras S. GemC1 is a critical switch for neural stem cell generation in the postnatal brain. Glia. 2019 12; 67(12):2360-2373. PMID: 31328313.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  58. Huang H, Song S, Banerjee S, Jiang T, Zhang J, Kahle KT, Sun D, Zhang Z. The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases. Aging Dis. 2019 Jun; 10(3):626-636. PMID: 31165006.
    Citations: 11     
  59. Date P, Ackermann P, Furey C, Fink IB, Jonas S, Khokha MK, Kahle KT, Deniz E. Visualizing flow in an intact CSF network using optical coherence tomography: implications for human congenital hydrocephalus. Sci Rep. 2019 04 17; 9(1):6196. PMID: 30996265.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  60. Duy PQ, Furey CG, Kahle KT. Trim71/lin-41 Links an Ancient miRNA Pathway to Human Congenital Hydrocephalus. Trends Mol Med. 2019 06; 25(6):467-469. PMID: 30975633.
    Citations: 2     Fields:    Translation:HumansCells
  61. Zeng X, Hunt A, Jin SC, Duran D, Gaillard J, Kahle KT. EphrinB2-EphB4-RASA1 Signaling in Human Cerebrovascular Development and Disease. Trends Mol Med. 2019 04; 25(4):265-286. PMID: 30819650.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  62. Panchagnula S, Sularz AK, Kahle KT. Familial Trigeminal Neuralgia Cases Implicate Genetic Factors in Disease Pathogenesis. JAMA Neurol. 2019 01 01; 76(1):9-10. PMID: 30398541.
    Citations: 5     Fields:    Translation:HumansAnimals
  63. Duran D, Zeng X, Jin SC, Choi J, Nelson-Williams C, Yatsula B, Gaillard J, Furey CG, Lu Q, Timberlake AT, Dong W, Sorscher MA, Loring E, Klein J, Allocco A, Hunt A, Conine S, Karimy JK, Youngblood MW, Zhang J, DiLuna ML, Matouk CC, Mane S, Tikhonova IR, Castaldi C, López-Giráldez F, Knight J, Haider S, Soban M, Alper SL, Komiyama M, Ducruet AF, Zabramski JM, Dardik A, Walcott BP, Stapleton CJ, Aagaard-Kienitz B, Rodesch G, Jackson E, Smith ER, Orbach DB, Berenstein A, Bilguvar K, Vikkula M, Gunel M, Lifton RP, Kahle KT. Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation. Neuron. 2019 02 06; 101(3):429-443.e4. PMID: 30578106.
    Citations: 15     Fields:    Translation:HumansCells
  64. Coletti AM, Singh D, Kumar S, Shafin TN, Briody PJ, Babbitt BF, Pan D, Norton ES, Brown EC, Kahle KT, Del Bigio MR, Conover JC. Characterization of the ventricular-subventricular stem cell niche during human brain development. Development. 2018 10 26; 145(20). PMID: 30237244.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Furey C, Antwi P, Duran D, Timberlake AT, Nelson-Williams C, Matouk CC, DiLuna ML, Günel M, Kahle KT. 9p24 triplication in syndromic hydrocephalus with diffuse villous hyperplasia of the choroid plexus. Cold Spring Harb Mol Case Stud. 2018 10; 4(5). PMID: 29895553.
    Citations:    Fields:    Translation:HumansCells
  66. Furey CG, Zeng X, Dong W, Jin SC, Choi J, Timberlake AT, Dunbar AM, Allocco AA, Günel M, Lifton RP, Kahle KT. Human Genetics and Molecular Mechanisms of Congenital Hydrocephalus. World Neurosurg. 2018 Nov; 119:441-443. PMID: 30205212.
    Citations: 3     Fields:    Translation:HumansAnimals
  67. Fomchenko EI, Duran D, Jin SC, Dong W, Erson-Omay EZ, Antwi P, Allocco A, Gaillard JR, Huttner A, Gunel M, DiLuna ML, Kahle KT. De novo MYH9 mutation in congenital scalp hemangioma. Cold Spring Harb Mol Case Stud. 2018 08; 4(4). PMID: 29903892.
    Citations: 2     Fields:    Translation:Humans
  68. Furey CG, Choi J, Jin SC, Zeng X, Timberlake AT, Nelson-Williams C, Mansuri MS, Lu Q, Duran D, Panchagnula S, Allocco A, Karimy JK, Khanna A, Gaillard JR, DeSpenza T, Antwi P, Loring E, Butler WE, Smith ER, Warf BC, Strahle JM, Limbrick DD, Storm PB, Heuer G, Jackson EM, Iskandar BJ, Johnston JM, Tikhonova I, Castaldi C, López-Giráldez F, Bjornson RD, Knight JR, Bilguvar K, Mane S, Alper SL, Haider S, Guclu B, Bayri Y, Sahin Y, Apuzzo MLJ, Duncan CC, DiLuna ML, Günel M, Lifton RP, Kahle KT. De Novo Mutation in Genes Regulating Neural Stem Cell Fate in Human Congenital Hydrocephalus. Neuron. 2018 07 25; 99(2):302-314.e4. PMID: 29983323.
    Citations: 33     Fields:    Translation:HumansCells
  69. Subramanian HE, Mahajan A, Sommaruga S, Falcone GJ, Kahle KT, Matouk CC. The Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure Hydrocephalus. World Neurosurg. 2018 Nov; 119:e46-e52. PMID: 29981467.
    Citations: 2     Fields:    Translation:Humans
  70. Antwi P, Hong CS, Duran D, Jin SC, Dong W, DiLuna M, Kahle KT. A novel association of campomelic dysplasia and hydrocephalus with an unbalanced chromosomal translocation upstream of SOX9. Cold Spring Harb Mol Case Stud. 2018 06; 4(3). PMID: 29695406.
    Citations: 2     Fields:    Translation:Humans
  71. Walcott BP, Winkler EA, Zhou S, Birk H, Guo D, Koch MJ, Stapleton CJ, Spiegelman D, Dionne-Laporte A, Dion PA, Kahle KT, Rouleau GA, Lawton MT. Identification of a rare BMP pathway mutation in a non-syndromic human brain arteriovenous malformation via exome sequencing. Hum Genome Var. 2018; 5:18001. PMID: 29844917.
    Citations: 6     
  72. Montejo JD, Camara-Quintana JQ, Duran D, Rockefeller JM, Conine SB, Blaise AM, Kahle KT, DiLuna ML. Tubular approach to minimally invasive microdiscectomy for pediatric lumbar disc herniation. J Neurosurg Pediatr. 2018 05; 21(5):449-455. PMID: 29473813.
    Citations: 1     Fields:    Translation:Humans
  73. Chesler D, Bram R, Antwi P, Timberlake AT, DiLuna ML, Kahle KT. Non-syndromic single-suture craniosynostosis in triplets. Childs Nerv Syst. 2018 06; 34(6):1241-1245. PMID: 29460062.
    Citations:    Fields:    Translation:Humans
  74. Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW. Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. Pediatr Blood Cancer. 2018 05; 65(5):e26969. PMID: 29380516.
    Citations: 12     Fields:    Translation:Humans
  75. Duran D, Karschnia P, Gaillard JR, Karimy JK, Youngblood MW, DiLuna ML, Matouk CC, Aagaard-Kienitz B, Smith ER, Orbach DB, Rodesch G, Berenstein A, Gunel M, Kahle KT. Human genetics and molecular mechanisms of vein of Galen malformation. J Neurosurg Pediatr. 2018 04; 21(4):367-374. PMID: 29350590.
    Citations: 4     Fields:    Translation:Humans
  76. Penn DL, Lanpher AB, Klein JM, Kozakewich HPW, Kahle KT, Smith ER, Orbach DB. Multimodal treatment approach in a patient with multiple intracranial myxomatous aneurysms. J Neurosurg Pediatr. 2018 03; 21(3):315-321. PMID: 29303459.
    Citations: 4     Fields:    Translation:Humans
  77. Furey CG, Timberlake AT, Nelson-Williams C, Duran D, Li P, Jackson EM, Kahle KT. Xp22.2 Chromosomal Duplication in Familial Intracranial Arachnoid Cyst. JAMA Neurol. 2017 12 01; 74(12):1503-1504. PMID: 29052703.
    Citations: 2     Fields:    Translation:HumansCells
  78. Heubl M, Zhang J, Pressey JC, Al Awabdh S, Renner M, Gomez-Castro F, Moutkine I, Eugène E, Russeau M, Kahle KT, Poncer JC, Lévi S. GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase. Nat Commun. 2017 11 24; 8(1):1776. PMID: 29176664.
    Citations: 27     Fields:    Translation:AnimalsCells
  79. Timberlake AT, Furey CG, Choi J, Nelson-Williams C, Loring E, Galm A, Kahle KT, Steinbacher DM, Larysz D, Persing JA, Lifton RP. De novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis. Proc Natl Acad Sci U S A. 2017 08 29; 114(35):E7341-E7347. PMID: 28808027.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  80. Duran D, Messina RD, Beslow LA, Montejo JD, Karimy JK, Gavankar Furey C, Sheridan AD, Sze G, Yarman Y, DiLuna ML, Kahle KT. Malignant Cerebellar Edema Subsequent to Accidental Prescription Opioid Intoxication in Children. Front Neurol. 2017; 8:362. PMID: 28790973.
    Citations: 5     
  81. Zhang J, Karimy JK, Delpire E, Kahle KT. Pharmacological targeting of SPAK kinase in disorders of impaired epithelial transport. Expert Opin Ther Targets. 2017 08; 21(8):795-804. PMID: 28679296.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  82. Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT. Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus. Nat Med. 2017 Aug; 23(8):997-1003. PMID: 28692063.
    Citations: 78     Fields:    Translation:Animals
  83. Vasquez JC, Huttner A, Zhang L, Marks A, Chan A, Baehring JM, Kahle KT, Dhodapkar KM. SOX2 immunity and tissue resident memory in children and young adults with glioma. J Neurooncol. 2017 Aug; 134(1):41-53. PMID: 28620836.
    Citations: 16     Fields:    Translation:HumansCells
  84. Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends Neurosci. 2017 05; 40(5):276-294. PMID: 28431741.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  85. Grunwald Z, Beslow LA, Urday S, Vashkevich A, Ayres A, Greenberg SM, Goldstein JN, Leasure A, Shi FD, Kahle KT, Battey TW, Simard JM, Rosand J, Kimberly WT, Sheth KN. Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage. Neurocrit Care. 2017 04; 26(2):205-212. PMID: 27844466.
    Citations: 21     Fields:    Translation:Humans
  86. Gaillard J, Klein J, Duran D, Storey A, Scott RM, Kahle K, Smith ER. Incidence, clinical features, and treatment of familial moyamoya in pediatric patients: a single-institution series. J Neurosurg Pediatr. 2017 May; 19(5):553-559. PMID: 28291427.
    Citations:    Fields:    Translation:Humans
  87. Shekarabi M, Zhang J, Khanna AR, Ellison DH, Delpire E, Kahle KT. WNK Kinase Signaling in Ion Homeostasis and Human Disease. Cell Metab. 2017 02 07; 25(2):285-299. PMID: 28178566.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  88. Duran D, Hadzipasic M, Kahle KT. Mystery Case: Acute hydrocephalus caused by radiographically occult fourth ventricular outlet obstruction. Neurology. 2017 01 31; 88(5):e36-e37. PMID: 28138085.
    Citations: 1     Fields:    Translation:Humans
  89. Delpire E, Kahle KT. The KCC3 cotransporter as a therapeutic target for peripheral neuropathy. Expert Opin Ther Targets. 2017 02; 21(2):113-116. PMID: 28019725.
    Citations: 5     Fields:    Translation:HumansAnimals
  90. Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes Dev. 2016 12 15; 30(24):2684-2695. PMID: 28087713.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  91. Duran D, Jin SC, DeSpenza T, Nelson-Williams C, Cogal AG, Abrash EW, Harris PC, Lieske JC, Shimshak SJ, Mane S, Bilguvar K, DiLuna ML, Günel M, Lifton RP, Kahle KT. Digenic mutations of human OCRL paralogs in Dent's disease type 2 associated with Chiari I malformation. Hum Genome Var. 2016; 3:16042. PMID: 28018608.
    Citations: 4     
  92. Karimy JK, Duran D, Hu JK, Gavankar C, Gaillard JR, Bayri Y, Rice H, DiLuna ML, Gerzanich V, Marc Simard J, Kahle KT. Cerebrospinal fluid hypersecretion in pediatric hydrocephalus. Neurosurg Focus. 2016 Nov; 41(5):E10. PMID: 27798982.
    Citations: 17     Fields:    Translation:Humans
  93. Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. Sci Rep. 2016 10 26; 6:35986. PMID: 27782176.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  94. Zhang J, Deng X, Kahle KT. Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition. Sci Signal. 2016 10 18; 9(450):e3. PMID: 27811182.
    Citations: 4     Fields:    Translation:HumansAnimals
  95. Kahle KT, Flores B, Bharucha-Goebel D, Zhang J, Donkervoort S, Hegde M, Hussain G, Duran D, Liang B, Sun D, Bönnemann CG, Delpire E. Peripheral motor neuropathy is associated with defective kinase regulation of the KCC3 cotransporter. Sci Signal. 2016 08 02; 9(439):ra77. PMID: 27485015.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  96. Zhao H, Nepomuceno R, Gao X, Foley LM, Wang S, Begum G, Zhu W, Pigott VM, Falgoust LM, Kahle KT, Yang SS, Lin SH, Alper SL, Hitchens TK, Hu S, Zhang Z, Sun D. Deletion of the WNK3-SPAK kinase complex in mice improves radiographic and clinical outcomes in malignant cerebral edema after ischemic stroke. J Cereb Blood Flow Metab. 2017 Feb; 37(2):550-563. PMID: 26861815.
    Citations: 16     Fields:    Translation:AnimalsCells
  97. Lucchesi KM, Grant R, Kahle KT, Marks AM, DiLuna ML. Primary spinal myxopapillary ependymoma in the pediatric population: a study from the Surveillance, Epidemiology, and End Results (SEER) database. J Neurooncol. 2016 10; 130(1):133-140. PMID: 27423644.
    Citations: 7     Fields:    Translation:Humans
  98. Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. Neuroscientist. 2016 12; 22(6):555-562. PMID: 27130838.
    Citations: 31     Fields:    Translation:HumansAnimals
  99. Kahle KT, Schmouth JF, Lavastre V, Latremoliere A, Zhang J, Andrews N, Omura T, Laganière J, Rochefort D, Hince P, Castonguay G, Gaudet R, Mapplebeck JC, Sotocinal SG, Duan J, Ward C, Khanna AR, Mogil JS, Dion PA, Woolf CJ, Inquimbert P, Rouleau GA. Inhibition of the kinase WNK1/HSN2 ameliorates neuropathic pain by restoring GABA inhibition. Sci Signal. 2016 Mar 29; 9(421):ra32. PMID: 27025876.
    Citations: 18     Fields:    Translation:AnimalsCells
  100. Merner ND, Mercado A, Khanna AR, Hodgkinson A, Bruat V, Awadalla P, Gamba G, Rouleau GA, Kahle KT. Gain-of-function missense variant in SLC12A2, encoding the bumetanide-sensitive NKCC1 cotransporter, identified in human schizophrenia. J Psychiatr Res. 2016 Jun; 77:22-6. PMID: 26955005.
    Citations: 17     Fields:    Translation:AnimalsCells
  101. Terry AR, Kahle KT, Larvie M, Vyas JM, Stemmer-Rachamimov A. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 5-2016. A 43-Year-Old Man with Altered Mental Status and a History of Alcohol Use. N Engl J Med. 2016 Feb 18; 374(7):671-80. PMID: 26886525.
    Citations: 4     Fields:    Translation:HumansAnimals
  102. Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN. Treatment of Edema Associated With Intracerebral Hemorrhage. Curr Treat Options Neurol. 2016 Feb; 18(2):9. PMID: 26874842.
    Citations: 9     
  103. Bhuiyan MIH, Song S, Yuan H, Begum G, Kofler J, Kahle KT, Yang SS, Lin SH, Alper SL, Subramanya AR, Sun D. WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats. J Cereb Blood Flow Metab. 2017 Aug; 37(8):2780-2794. PMID: 27798271.
    Citations: 7     Fields:    Translation:AnimalsCells
  104. Kahle KT, Delpire E. Kinase-KCC2 coupling: Cl- rheostasis, disease susceptibility, therapeutic target. J Neurophysiol. 2016 Jan 01; 115(1):8-18. PMID: 26510764.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  105. Merner ND, Chandler MR, Bourassa C, Liang B, Khanna AR, Dion P, Rouleau GA, Kahle KT. Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia. Front Cell Neurosci. 2015; 9:386. PMID: 26528127.
    Citations: 33     
  106. Kahle KT, Kulkarni AV, Limbrick DD, Warf BC. Hydrocephalus in children. Lancet. 2016 Feb 20; 387(10020):788-99. PMID: 26256071.
    Citations: 116     Fields:    Translation:Humans
  107. Adragna NC, Ravilla NB, Lauf PK, Begum G, Khanna AR, Sun D, Kahle KT. Regulated phosphorylation of the K-Cl cotransporter KCC3 is a molecular switch of intracellular potassium content and cell volume homeostasis. Front Cell Neurosci. 2015; 9:255. PMID: 26217182.
    Citations: 15     
  108. Kahle KT, Khanna AR, Alper SL, Adragna NC, Lauf PK, Sun D, Delpire E. K-Cl cotransporters, cell volume homeostasis, and neurological disease. Trends Mol Med. 2015 Aug; 21(8):513-23. PMID: 26142773.
    Citations: 42     Fields:    Translation:HumansCells
  109. Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J, Khanna AR, Bishop PN, Shokat KM, Medina I. WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Sci Signal. 2015 Jun 30; 8(383):ra65. PMID: 26126716.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  110. Begum G, Yuan H, Kahle KT, Li L, Wang S, Shi Y, Shmukler BE, Yang SS, Lin SH, Alper SL, Sun D. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke. 2015 Jul; 46(7):1956-1965. PMID: 26069258.
    Citations: 38     Fields:    Translation:AnimalsCells
  111. Khanna A, Simard JM, Kahle KT. Progesterone in traumatic brain injury. N Engl J Med. 2015 04 30; 372(18):1765-6. PMID: 25923560.
    Citations: 1     Fields:    Translation:Humans
  112. Ang JW, Khanna A, Walcott BP, Kahle KT, Eskandar EN. Central nervous system lymphoma presenting as trigeminal neuralgia: A diagnostic challenge. J Clin Neurosci. 2015 Jul; 22(7):1188-90. PMID: 25865026.
    Citations: 3     Fields:    Translation:Humans
  113. Karimy JK, Kahle KT, Kurland DB, Yu E, Gerzanich V, Simard JM. A novel method to study cerebrospinal fluid dynamics in rats. J Neurosci Methods. 2015 Feb 15; 241:78-84. PMID: 25554415.
    Citations: 15     Fields:    Translation:Animals
  114. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014 Sep 05; 345(6201):1130. PMID: 25190789.
    Citations: 7     Fields:    Translation:AnimalsCells
  115. Walcott BP, Miller JC, Kwon CS, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM, Kahle KT, Kimberly WT, Sheth KN. Outcomes in severe middle cerebral artery ischemic stroke. Neurocrit Care. 2014 Aug; 21(1):20-6. PMID: 23839704.
    Citations: 20     Fields:    Translation:Humans
  116. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. PMID: 25032616.
    Citations:    
  117. Campbell SL, Robel S, Cuddapah VA, Robert S, Buckingham SC, Kahle KT, Sontheimer H. GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy. Glia. 2015 Jan; 63(1):23-36. PMID: 25066727.
    Citations: 42     Fields:    Translation:AnimalsCells
  118. Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT. The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters. Sci Signal. 2014 Jul 15; 7(334):re3. PMID: 25028718.
    Citations: 102     Fields:    Translation:HumansCells
  119. Kahle KT, Merner ND, Friedel P, Silayeva L, Liang B, Khanna A, Shang Y, Lachance-Touchette P, Bourassa C, Levert A, Dion PA, Walcott B, Spiegelman D, Dionne-Laporte A, Hodgkinson A, Awadalla P, Nikbakht H, Majewski J, Cossette P, Deeb TZ, Moss SJ, Medina I, Rouleau GA. Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy. EMBO Rep. 2014 Jul; 15(7):766-74. PMID: 24928908.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  120. Puskarjov M, Kahle KT, Ruusuvuori E, Kaila K. Pharmacotherapeutic targeting of cation-chloride cotransporters in neonatal seizures. Epilepsia. 2014 Jun; 55(6):806-18. PMID: 24802699.
    Citations: 47     Fields:    Translation:Humans
  121. Kahle KT, Khanna A, Clapham DE, Woolf CJ. Therapeutic restoration of spinal inhibition via druggable enhancement of potassium-chloride cotransporter KCC2-mediated chloride extrusion in peripheral neuropathic pain. JAMA Neurol. 2014 May; 71(5):640-5. PMID: 24615367.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  122. de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J. The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters. Biochem J. 2014 Mar 15; 458(3):559-73. PMID: 24393035.
    Citations: 87     Fields:    Translation:HumansCells
  123. Zhu W, Begum G, Pointer K, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration. Mol Cancer. 2014 Feb 20; 13:31. PMID: 24555568.
    Citations: 33     Fields:    Translation:HumansCells
  124. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science. 2014 Feb 07; 343(6171):670-5. PMID: 24503855.
    Citations: 92     Fields:    Translation:AnimalsCells
  125. Medina I, Friedel P, Rivera C, Kahle KT, Kourdougli N, Uvarov P, Pellegrino C. Current view on the functional regulation of the neuronal K(+)-Cl(-) cotransporter KCC2. Front Cell Neurosci. 2014; 8:27. PMID: 24567703.
    Citations: 75     
  126. Sun D, Kahle KT. Dysregulation of diverse ion transport pathways controlling cell volume homoestasis contribute to neuroglial cell injury following ischemic stroke. Transl Stroke Res. 2014 Feb; 5(1):1-2. PMID: 24464825.
    Citations: 1     Fields:    Translation:HumansCells
  127. Khanna A, Walcott BP, Kahle KT, Simard JM. Effect of glibenclamide on the prevention of secondary brain injury following ischemic stroke in humans. Neurosurg Focus. 2014 Jan; 36(1):E11. PMID: 24380477.
    Citations: 9     Fields:    Translation:Humans
  128. Khanna A, Kahle KT, Walcott BP, Gerzanich V, Simard JM. Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema. Transl Stroke Res. 2014 Feb; 5(1):3-16. PMID: 24323726.
    Citations: 33     Fields:    Translation:HumansCells
  129. Lee HK, Ahmed MM, King KC, Miranpuri GS, Kahle KT, Resnick DK, Sun D. Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury. Spine J. 2014 May 01; 14(5):777-81. PMID: 24239489.
    Citations: 10     Fields:    Translation:AnimalsCells
  130. Kahle KT, Deeb TZ, Puskarjov M, Silayeva L, Liang B, Kaila K, Moss SJ. Modulation of neuronal activity by phosphorylation of the K-Cl cotransporter KCC2. Trends Neurosci. 2013 Dec; 36(12):726-737. PMID: 24139641.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  131. Ryu JH, Walcott BP, Kahle KT, Sheth SA, Peterson RT, Nahed BV, Coumans JV, Simard JM. Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury. Neurocrit Care. 2013 Oct; 19(2):222-31. PMID: 23468135.
    Citations: 6     Fields:    Translation:Humans
  132. Khanna A, Venteicher AS, Walcott BP, Kahle KT, Mordes DA, William CM, Ghogawala Z, Ogilvy CS. Glioblastoma mimicking an arteriovenous malformation. Front Neurol. 2013; 4:144. PMID: 24137154.
    Citations: 5     
  133. Walcott BP, Neal JB, Sheth SA, Kahle KT, Eskandar EN, Coumans JV, Nahed BV. The incidence of complications in elective cranial neurosurgery associated with dural closure material. J Neurosurg. 2014 Jan; 120(1):278-84. PMID: 24032702.
    Citations: 5     Fields:    Translation:Humans
  134. Codd PJ, Venteicher AS, Agarwalla PK, Kahle KT, Jho DH. Endoscopic burr hole evacuation of an acute subdural hematoma. J Clin Neurosci. 2013 Dec; 20(12):1751-3. PMID: 23962631.
    Citations: 8     Fields:    Translation:Humans
  135. Khanna A, Walcott BP, Kahle KT. Limitations of Current GABA Agonists in Neonatal Seizures: Toward GABA Modulation Via the Targeting of Neuronal Cl(-) Transport. Front Neurol. 2013; 4:78. PMID: 23805124.
    Citations: 14     
  136. Kahle KT, Duhaime AC. Intracranial-pressure monitoring in traumatic brain injury. N Engl J Med. 2013 05 02; 368(18):1750. PMID: 23635062.
    Citations: 2     Fields:    Translation:Humans
  137. Arroyo JP, Kahle KT, Gamba G. The SLC12 family of electroneutral cation-coupled chloride cotransporters. Mol Aspects Med. 2013 Apr-Jun; 34(2-3):288-98. PMID: 23506871.
    Citations: 54     Fields:    Translation:Humans
  138. Cleary RT, Sun H, Huynh T, Manning SM, Li Y, Rotenberg A, Talos DM, Kahle KT, Jackson M, Rakhade SN, Berry G, Berry G, Jensen FE. Bumetanide enhances phenobarbital efficacy in a rat model of hypoxic neonatal seizures. PLoS One. 2013; 8(3):e57148. PMID: 23536761.
    Citations: 57     Fields:    Translation:AnimalsCells
  139. Kahle KT, Walcott BP, Simard JM. Continuous hyperosmolar therapy for traumatic brain injury-associated cerebral edema: as good as it gets, or an iatrogenic secondary insult? J Clin Neurosci. 2013 Jan; 20(1):30-1. PMID: 23200533.
    Citations: 4     Fields:    Translation:Humans
  140. Walcott BP, Kahle KT, Simard JM. The DECRA trial and decompressive craniectomy in diffuse traumatic brain injury: is decompression really ineffective? World Neurosurg. 2013 Jan; 79(1):80-1. PMID: 23159659.
    Citations: 3     Fields:    
  141. Algharabil J, Kintner DB, Wang Q, Begum G, Clark PA, Yang SS, Lin SH, Kahle KT, Kuo JS, Sun D. Inhibition of Na(+)-K(+)-2Cl(-) cotransporter isoform 1 accelerates temozolomide-mediated apoptosis in glioblastoma cancer cells. Cell Physiol Biochem. 2012; 30(1):33-48. PMID: 22759954.
    Citations: 25     Fields:    Translation:HumansCells
  142. Walcott BP, Kahle KT, Butler WE. Endoscopic treatment of hydrocephalus. Arch Neurol. 2012 May; 69(5):664. PMID: 22271236.
    Citations:    Fields:    Translation:Humans
  143. Walcott BP, Edlow BL, Xia Z, Kahle KT, Nahed BV, Schmahmann JD. Steroid responsive A3243G mutation MELAS: clinical and radiographic evidence for regional hyperperfusion leading to neuronal loss. Neurologist. 2012 May; 18(3):159-70. PMID: 22549360.
    Citations: 6     Fields:    Translation:Humans
  144. Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E. The GABA excitatory/inhibitory shift in brain maturation and neurological disorders. Neuroscientist. 2012 Oct; 18(5):467-86. PMID: 22547529.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  145. Walcott BP, Nahed BV, Mohyeldin A, Coumans JV, Kahle KT, Ferreira MJ. Chordoma: current concepts, management, and future directions. Lancet Oncol. 2012 Feb; 13(2):e69-76. PMID: 22300861.
    Citations: 189     Fields:    Translation:Humans
  146. Walcott BP, Kahle KT, Simard JM. Novel treatment targets for cerebral edema. Neurotherapeutics. 2012 Jan; 9(1):65-72. PMID: 22125096.
    Citations: 58     Fields:    Translation:Humans
  147. Walcott BP, Nahed BV, Kahle KT, Duhaime AC, Sharma N, Eskandar EN. Deep brain stimulation for medically refractory life-threatening status dystonicus in children. J Neurosurg Pediatr. 2012 Jan; 9(1):99-102. PMID: 22208329.
    Citations: 5     Fields:    Translation:Humans
  148. Walcott BP, Kuklina EV, Nahed BV, George MG, Kahle KT, Simard JM, Asaad WF, Coumans JV. Craniectomy for malignant cerebral infarction: prevalence and outcomes in US hospitals. PLoS One. 2011; 6(12):e29193. PMID: 22195021.
    Citations: 21     Fields:    Translation:Humans
  149. Walcott BP, Kahle KT, Nahed BV, Coumans JV, Asaad WF. The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury. Eur Spine J. 2012 Jun; 21 Suppl 4:S492-4. PMID: 22167452.
    Citations:    Fields:    Translation:Humans
  150. Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53. PMID: 22157079.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  151. Walcott BP, Nahed BV, Sarpong Y, Kahle KT, Sekhar LN, Ferreira MJ. Incidence of cerebrospinal fluid leak following petrosectomy and analysis of avoidance techniques. J Clin Neurosci. 2012 Jan; 19(1):92-4. PMID: 22104349.
    Citations: 1     Fields:    Translation:Humans
  152. Stapleton CJ, Walcott BP, Kahle KT, Codd PJ, Nahed BV, Chen L, Robison NJ, Delalle I, Goumnerova LC, Jackson EM. Diffuse central neurocytoma with craniospinal dissemination. J Clin Neurosci. 2012 Jan; 19(1):163-6. PMID: 22088950.
    Citations: 4     Fields:    Translation:Humans
  153. Walcott BP, Nahed BV, Kahle KT, Sekhar LN, Ferreira MJ. Cerebrovascular bypass and aneurysm trapping for the treatment of an A2-segment anterior cerebral artery pseudoaneurysm and herniation through a skull base defect following trauma. J Clin Neurosci. 2012 Jan; 19(1):149-51. PMID: 22051032.
    Citations: 1     Fields:    Translation:Humans
  154. Kesari S, Advani SJ, Lawson JD, Kahle KT, Ng K, Carter B, Chen CC. DNA damage response and repair: insights into strategies for radiation sensitization of gliomas. Future Oncol. 2011 Nov; 7(11):1335-46. PMID: 22044206.
    Citations: 21     Fields:    Translation:HumansCells
  155. Walcott BP, Coumans JV, Mian MK, Nahed BV, Kahle KT. Interfacility helicopter ambulance transport of neurosurgical patients: observations, utilization, and outcomes from a quaternary level care hospital. PLoS One. 2011; 6(10):e26216. PMID: 22022572.
    Citations: 9     Fields:    Translation:Humans
  156. Walcott BP, Nahed BV, Redjal N, Stein TD, Kahle KT, Coumans JV. Pathological mechanism of lumbar disc herniation resulting in neurogenic muscle hypertrophy. J Clin Neurosci. 2011 Dec; 18(12):1682-4. PMID: 21985744.
    Citations: 3     Fields:    Translation:Humans
  157. Walcott BP, Coumans JV, Kahle KT. Diagnostic pitfalls in spine surgery: masqueraders of surgical spine disease. Neurosurg Focus. 2011 Oct; 31(4):E1. PMID: 21961853.
    Citations:    Fields:    Translation:Humans
  158. Bashinskaya B, Nahed BV, Redjal N, Kahle KT, Walcott BP. Trends in Peptic Ulcer Disease and the Identification of Helicobacter Pylori as a Causative Organism: Population-based Estimates from the US Nationwide Inpatient Sample. J Glob Infect Dis. 2011 Oct; 3(4):366-70. PMID: 22224001.
    Citations: 12     
  159. Schanker BD, Walcott BP, Nahed BV, Kahle KT, Li YM, Coumans JV. Familial Chiari malformation: case series. Neurosurg Focus. 2011 Sep; 31(3):E1. PMID: 21882906.
    Citations: 8     Fields:    Translation:Humans
  160. Coumans JV, Walcott BP, Butler WE, Nahed BV, Kahle KT. Volumetric analysis of syringomyelia following hindbrain decompression for Chiari malformation Type I: syringomyelia resolution follows exponential kinetics. Neurosurg Focus. 2011 Sep; 31(3):E4. PMID: 21882909.
    Citations: 2     Fields:    Translation:Humans
  161. Walcott BP, Kahle KT. Blast-related traumatic brain injury in U.S. military personnel. N Engl J Med. 2011 09 01; 365(9):860. PMID: 21879908.
    Citations: 1     Fields:    Translation:Humans
  162. Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet? Epilepsia. 2011 Sep; 52(9):1559-69. PMID: 21838793.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  163. Simard JM, Kahle KT, Walcott BP. Craniectomy in diffuse traumatic brain injury. N Engl J Med. 2011 07 28; 365(4):374; author reply 376. PMID: 21793753.
    Citations: 1     Fields:    Translation:Humans
  164. Walcott BP, Cvetanovich GL, Barnard ZR, Nahed BV, Kahle KT, Curry WT. Surgical treatment and outcomes of metastatic breast cancer to the spine. J Clin Neurosci. 2011 Oct; 18(10):1336-9. PMID: 21782449.
    Citations: 8     Fields:    Translation:Humans
  165. Aghi MK, Walcott BP, Nahed BV, Cvetanovich GL, Kahle KT, Redjal N, Coumans JV. Determinants of initial bone graft volume loss in posterolateral lumbar fusion. J Clin Neurosci. 2011 Sep; 18(9):1193-6. PMID: 21745744.
    Citations: 1     Fields:    Translation:Humans
  166. Kahle KT, Walcott BP, Nahed BV, Barnard ZR, Lo EH, Buonanno FS, Venna N, Ning M. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci. 2011 Sep; 18(9):1245-8. PMID: 21742505.
    Citations: 7     Fields:    Translation:HumansCells
  167. Rinehart J, Vázquez N, Kahle KT, Hodson CA, Ring AM, Gulcicek EE, Louvi A, Bobadilla NA, Gamba G, Lifton RP. WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters. J Biol Chem. 2011 Aug 26; 286(34):30171-80. PMID: 21733846.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  168. Walcott BP, Nahed BV, Kahle KT, Redjal N, Coumans JV. Determination of geographic variance in stroke prevalence using Internet search engine analytics. Neurosurg Focus. 2011 Jun; 30(6):E19. PMID: 21631220.
    Citations: 14     Fields:    Translation:Humans
  169. Walcott BP, Kahle KT, Wain JC, Borges LF. Giant thoracic meningocele associated with neurofibromatosis 1. Neurology. 2011 May 31; 76(22):1943. PMID: 21624995.
    Citations:    Fields:    Translation:Humans
  170. Walcott BP, Pisapia JM, Nahed BV, Kahle KT, Ogilvy CS. Early experience with flow diverting endoluminal stents for the treatment of intracranial aneurysms. J Clin Neurosci. 2011 Jul; 18(7):891-4. PMID: 21571535.
    Citations: 8     Fields:    Translation:Humans
  171. Stapleton CJ, Walcott BP, Linskey KR, Kahle KT, Nahed BV, Asaad WF. Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity. J Clin Neurosci. 2011 Jun; 18(6):857-60. PMID: 21514167.
    Citations: 4     Fields:    Translation:Humans