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profileIonita Calin Ghiran, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Allergy, CLSBldg - Rm 934
3 Blackfan Circle
Boston MA 02115
Phone617/735-4103
Fax617/667-5541
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA218500     (IVANOV, ALEXANDER R.)Mar 15, 2018 - Feb 28, 2023
NIH/NCI
Effect of methodological and biological variability on molecular profiling of extracellular vesicles in cancer detection
Role: Co-Principal Investigator

R21TW009915     (GHIRAN, IONITA CALIN)Sep 10, 2014 - Apr 30, 2016
NIH/FIC
Malaria screening in resource-poor settings using a simple, power-free, cell phone-friendly device
Role: Principal Investigator

U01HL126497     (GHIRAN, IONITA CALIN)Aug 1, 2014 - Apr 30, 2019
NIH/NHLBI
Impact of circadian rhythm in obtaining reference profiles of exRNAs in healthy i
Role: Principal Investigator

R01HL096795     (GHIRAN, IONITA CALIN)May 1, 2011 - Feb 28, 2015
NIH/NHLBI
Modulation of erythrocyte function by complement
Role: Principal Investigator

R21AI057983     (GHIRAN, IONITA CALIN)Mar 15, 2004 - Aug 31, 2006
NIH/NIAID
Neutrophil ecto-Calreticulin: Implications for Immunity
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Smith AS, Nowak RB, Zhou S, Giannetto M, Gokhin DS, Papoin J, Ghiran IC, Blanc L, Wan J, Fowler VM. Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane curvature and deformability. Proc Natl Acad Sci U S A. 2018 Apr 02. PMID: 29610350.
    View in: PubMed
  2. Andersen MS, Lu S, Lopez GJ, Lassen AT, Shapiro NI, Ghiran IC. A Novel Implementation of Magnetic Levitation to Quantify Leukocyte Size, Morphology, and Magnetic Properties to Identify Patients with Sepsis. Shock. 2018 Mar 20. PMID: 29561389.
    View in: PubMed
  3. Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Camacho V, Minami K, Nian Y, Koduru S, El Fatimy R, Ghiran I, Trachtenberg AJ, de la Fuente MA, Azuma H, Akbari O, Tullius SG, Vasudevan A, Elkhal A. Mast cells regulate CD4+ T-cell differentiation in the absence of antigen presentation. J Allergy Clin Immunol. 2018 Feb 20. PMID: 29470999.
    View in: PubMed
  4. Babatunde KA, Mbagwu S, Hernández-Castañeda MA, Adapa SR, Walch M, Filgueira L, Falquet L, Jiang RHY, Ghiran I, Mantel PY. Malaria infected red blood cells release small regulatory RNAs through extracellular vesicles. Sci Rep. 2018 Jan 17; 8(1):884. PMID: 29343745.
    View in: PubMed
  5. Andersen MS, Howard E, Lu S, Richard M, Gregory M, Ogembo G, Mazor O, Gorelik P, Shapiro NI, Sharda AV, Ghiran I. Detection of membrane-bound and soluble antigens by magnetic levitation. Lab Chip. 2017 Oct 11; 17(20):3462-3473. PMID: 28905952.
    View in: PubMed
  6. Shah R, Yeri A, Das A, Courtright-Lim A, Ziegler O, Gervino E, Ocel J, Quintero-Pinzon P, Wooster L, Bailey CS, Tanriverdi K, Beaulieu LM, Freedman JE, Ghiran I, Lewis GD, Van Keuren-Jensen K, Das S. Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: brief report. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1162-H1167. PMID: 28916639.
    View in: PubMed
  7. Bei Y, Xu T, Lv D, Yu P, Xu J, Che L, Das A, Tigges J, Toxavidis V, Ghiran I, Shah R, Li Y, Zhang Y, Das S, Xiao J. Exercise-induced circulating extracellular vesicles protect against cardiac ischemia-reperfusion injury. Basic Res Cardiol. 2017 Jul; 112(4):38. PMID: 28534118.
    View in: PubMed
  8. Simonson B, Subramanya V, Chan MC, Zhang A, Franchino H, Ottaviano F, Mishra MK, Knight AC, Hunt D, Ghiran I, Khurana TS, Kontaridis MI, Rosenzweig A, Das S. DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress. Sci Signal. 2017 Feb 28; 10(468). PMID: 28246202.
    View in: PubMed
  9. Kuo WP, Tigges JC, Toxavidis V, Ghiran I. Red Blood Cells: A Source of Extracellular Vesicles. Methods Mol Biol. 2017; 1660:15-22. PMID: 28828644.
    View in: PubMed
  10. Akuthota P, Carmo LA, Bonjour K, Murphy RO, Silva TP, Gamalier JP, Capron KL, Tigges J, Toxavidis V, Camacho V, Ghiran I, Ueki S, Weller PF, Melo RC. Extracellular Microvesicle Production by Human Eosinophils Activated by "Inflammatory" Stimuli. Front Cell Dev Biol. 2016; 4:117. PMID: 27833910.
    View in: PubMed
  11. Mantel PY, Hjelmqvist D, Walch M, Kharoubi-Hess S, Nilsson S, Ravel D, Ribeiro M, Grüring C, Ma S, Padmanabhan P, Trachtenberg A, Ankarklev J, Brancucci NM, Huttenhower C, Duraisingh MT, Ghiran I, Kuo WP, Filgueira L, Martinelli R, Marti M. Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria. Nat Commun. 2016 Oct 10; 7:12727. PMID: 27721445.
    View in: PubMed
  12. Felton EJ, Velasquez A, Lu S, Murphy RO, ElKhal A, Mazor O, Gorelik P, Sharda A, Ghiran IC. Detection and quantification of subtle changes in red blood cell density using a cell phone. Lab Chip. 2016 Aug 16; 16(17):3286-95. PMID: 27431921.
    View in: PubMed
  13. Elkhal A, Rodriguez Cetina Biefer H, Heinbokel T, Uehara H, Quante M, Seyda M, Schuitenmaker JM, Krenzien F, Camacho V, de la Fuente MA, Ghiran I, Tullius SG. NAD(+) regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4(+) CD25(+) Foxp3(+) T cells independent. Sci Rep. 2016 Mar 01; 6:22325. PMID: 26928119; PMCID: PMC4772111.
  14. Khoory J, Estanislau J, Elkhal A, Lazaar A, Melhorn MI, Brodsky A, Illigens B, Hamachi I, Kurishita Y, Ivanov AR, Shevkoplyas S, Shapiro NI, Ghiran IC. Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function. PLoS One. 2016; 11(1):e0141206. PMID: 26784696; PMCID: PMC4718526.
  15. Danielson KM, Estanislau J, Tigges J, Toxavidis V, Camacho V, Felton EJ, Khoory J, Kreimer S, Ivanov AR, Mantel PY, Jones J, Akuthota P, Das S, Ghiran I. Diurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry. PLoS One. 2016; 11(1):e0144678. PMID: 26745887; PMCID: PMC4706300.
  16. Knowlton SM, Sencan I, Aytar Y, Khoory J, Heeney MM, Ghiran IC, Tasoglu S. Sickle cell detection using a smartphone. Sci Rep. 2015 Oct 22; 5:15022. PMID: 26492382; PMCID: PMC4615037.
  17. Quesenberry PJ, Aliotta J, Camussi G, Abdel-Mageed AB, Wen S, Goldberg L, Zhang HG, Tetta C, Franklin J, Coffey RJ, Danielson K, Subramanya V, Ghiran I, Das S, Chen CC, Pusic KM, Pusic AD, Chatterjee D, Kraig RP, Balaj L, Dooner M. Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:27575. PMID: 26320942; PMCID: PMC4553260.
  18. Knowlton S, Yu CH, Jain N, Ghiran IC, Tasoglu S. Smart-Phone Based Magnetic Levitation for Measuring Densities. PLoS One. 2015; 10(8):e0134400. PMID: 26308615; PMCID: PMC4550410.
  19. Tasoglu S, Khoory JA, Tekin HC, Thomas C, Karnoub AE, Ghiran IC, Demirci U. Cytometry: Levitational Image Cytometry with Temporal Resolution (Adv. Mater. 26/2015). Adv Mater. 2015 Jul; 27(26):3900. PMID: 26149363.
    View in: PubMed
  20. Durmus NG, Tekin HC, Guven S, Sridhar K, Arslan Yildiz A, Calibasi G, Ghiran I, Davis RW, Steinmetz LM, Demirci U. Magnetic levitation of single cells. Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28):E3661-8. PMID: 26124131; PMCID: PMC4507238.
  21. Tasoglu S, Khoory JA, Tekin HC, Thomas C, Karnoub AE, Ghiran IC, Demirci U. Levitational Image Cytometry with Temporal Resolution. Adv Mater. 2015 Jul 08; 27(26):3901-8. PMID: 26058598; PMCID: PMC4631436.
  22. Kreimer S, Belov AM, Ghiran I, Murthy SK, Frank DA, Ivanov AR. Mass-spectrometry-based molecular characterization of extracellular vesicles: lipidomics and proteomics. J Proteome Res. 2015 Jun 05; 14(6):2367-84. PMID: 25927954.
    View in: PubMed
  23. Gokhin DS, Nowak RB, Khoory JA, Piedra Ade L, Ghiran IC, Fowler VM. Dynamic actin filaments control the mechanical behavior of the human red blood cell membrane. Mol Biol Cell. 2015 May 01; 26(9):1699-710. PMID: 25717184; PMCID: PMC4436781.
  24. Tullius SG, Biefer HR, Li S, Trachtenberg AJ, Edtinger K, Quante M, Krenzien F, Uehara H, Yang X, Kissick HT, Kuo WP, Ghiran I, de la Fuente MA, Arredouani MS, Camacho V, Tigges JC, Toxavidis V, El Fatimy R, Smith BD, Vasudevan A, ElKhal A. NAD+ protects against EAE by regulating CD4+ T-cell differentiation. Nat Commun. 2014 Oct 07; 5:5101. PMID: 25290058; PMCID: PMC4205890.
  25. El Assal R, Guven S, Gurkan UA, Gozen I, Shafiee H, Dalbeyler S, Abdalla N, Thomas G, Fuld W, Illigens BM, Estanislau J, Khoory J, Kaufman R, Zylberberg C, Lindeman N, Wen Q, Ghiran I, Demirci U. Bio-inspired cryo-ink preserves red blood cell phenotype and function during nanoliter vitrification. Adv Mater. 2014 Sep 03; 26(33):5815-22. PMID: 25047246; PMCID: PMC4161503.
  26. Muroya T, Kannan L, Ghiran IC, Shevkoplyas SS, Paz Z, Tsokos M, Dalle Lucca JJ, Shapiro NI, Tsokos GC. C4d deposits on the surface of RBCs in trauma patients and interferes with their function. Crit Care Med. 2014 May; 42(5):e364-72. PMID: 24448198; PMCID: PMC4099476.
  27. Melhorn MI, Brodsky AS, Estanislau J, Khoory JA, Illigens B, Hamachi I, Kurishita Y, Fraser AD, Nicholson-Weller A, Dolmatova E, Duffy HS, Ghiran IC. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process. J Biol Chem. 2013 Oct 25; 288(43):31139-53. PMID: 24022490; PMCID: PMC3829426.
  28. Mantel PY, Hoang AN, Goldowitz I, Potashnikova D, Hamza B, Vorobjev I, Ghiran I, Toner M, Irimia D, Ivanov AR, Barteneva N, Marti M. Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host Microbe. 2013 May 15; 13(5):521-34. PMID: 23684304; PMCID: PMC3687518.
  29. Ogembo JG, Kannan L, Ghiran I, Nicholson-Weller A, Finberg RW, Tsokos GC, Fingeroth JD. Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor. Cell Rep. 2013 Feb 21; 3(2):371-85. PMID: 23416052; PMCID: PMC3633082.
  30. Ueki S, Melo RC, Ghiran I, Spencer LA, Dvorak AM, Weller PF. Eosinophil extracellular DNA trap cell death mediates lytic release of free secretion-competent eosinophil granules in humans. Blood. 2013 Mar 14; 121(11):2074-83. PMID: 23303825; PMCID: PMC3596967.
  31. Borschukova O, Paz Z, Ghiran IC, Liu CC, Kao AH, Manzi S, Ahearn JM, Tsokos GC. Complement fragment C3d is colocalized within the lipid rafts of T cells and promotes cytokine production. Lupus. 2012 Oct; 21(12):1294-304. PMID: 22851413.
    View in: PubMed
  32. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. Systemic lupus erythematosus serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2011 Feb; 63(2):503-12. PMID: 21280005; PMCID: PMC3334350.
  33. Ghiran IC. Introduction to fluorescence microscopy. Methods Mol Biol. 2011; 689:93-136. PMID: 21153789.
    View in: PubMed
  34. Ghiran IC, Zeidel ML, Shevkoplyas SS, Burns JM, Tsokos GC, Kyttaris VC. SLE serum deposits C4d on red blood cells, decreases red blood cell membrane deformability, and promotes nitric oxide production. Arthritis Rheum. 2010 Nov 15. PMID: 21080356.
    View in: PubMed
  35. Glodek AM, Mirchev R, Golan DE, Khoory JA, Burns JM, Shevkoplyas SS, Nicholson-Weller A, Ghiran IC. Ligation of complement receptor 1 increases erythrocyte membrane deformability. Blood. 2010 Dec 23; 116(26):6063-71. PMID: 20861458; PMCID: PMC3031392.
  36. Ghiran I, Kuo WP. Examining the role of microvesicles to develop prognostic and diagnostic assays. J Appl Oral Sci. 2010 Sep-Oct; 18(5):i. PMID: 21085796.
    View in: PubMed
  37. Li J, Wang JP, Ghiran I, Cerny A, Szalai AJ, Briles DE, Finberg RW. Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence. Infect Immun. 2010 Jul; 78(7):3129-35. PMID: 20439480; PMCID: PMC2897369.
  38. Celli JP, Turner BS, Afdhal NH, Keates S, Ghiran I, Kelly CP, Ewoldt RH, McKinley GH, So P, Erramilli S, Bansil R. Helicobacter pylori moves through mucus by reducing mucin viscoelasticity. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14321-6. PMID: 19706518; PMCID: PMC2732822.
  39. Lim KH, Salahuddin S, Qiu L, Fang H, Vitkin E, Ghiran IC, Modell MD, Takoudes T, Itzkan I, Hanlon EB, Sachs BP, Perelman LT. Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis. Opt Lett. 2009 May 01; 34(9):1483-5. PMID: 19412313.
    View in: PubMed
  40. Karnchanaphanurach P, Mirchev R, Ghiran I, Asara JM, Papahadjopoulos-Sternberg B, Nicholson-Weller A, Golan DE. C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex. J Clin Invest. 2009 Apr; 119(4):788-801. PMID: 19258706; PMCID: PMC2662546.
  41. Neves JS, Perez SA, Spencer LA, Melo RC, Reynolds L, Ghiran I, Mahmudi-Azer S, Odemuyiwa SO, Dvorak AM, Moqbel R, Weller PF. Eosinophil granules function extracellularly as receptor-mediated secretory organelles. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18478-83. PMID: 19017810; PMCID: PMC2587599.
  42. Ghiran I, Glodek AM, Weaver G, Klickstein LB, Nicholson-Weller A. Ligation of erythrocyte CR1 induces its clustering in complex with scaffolding protein FAP-1. Blood. 2008 Oct 15; 112(8):3465-73. PMID: 18684861; PMCID: PMC2569183.
  43. Costa M, Ghiran I, Peng CK, Nicholson-Weller A, Goldberger AL. Complex dynamics of human red blood cell flickering: alterations with in vivo aging. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Aug; 78(2 Pt 1):020901. PMID: 18850779; PMCID: PMC2633132.
  44. Wang HB, Ghiran I, Matthaei K, Weller PF. Airway eosinophils: allergic inflammation recruited professional antigen-presenting cells. J Immunol. 2007 Dec 01; 179(11):7585-92. PMID: 18025204; PMCID: PMC2735454.
  45. Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17255-60. PMID: 17956980; PMCID: PMC2077242.
  46. Chen CH, Ghiran I, Beurskens FJ, Weaver G, Vincent JA, Nicholson-Weller A, Klickstein LB. Antibody CR1-2B11 recognizes a non-polymorphic epitope of human CR1 (CD35). Clin Exp Immunol. 2007 Jun; 148(3):546-54. PMID: 17493021; PMCID: PMC1941935.
  47. Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PJ, Choe H. SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem. 2006 Feb 10; 281(6):3198-203. PMID: 16339146.
    View in: PubMed
  48. Melo RC, Spencer LA, Perez SA, Ghiran I, Dvorak AM, Weller PF. Human eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments. Traffic. 2005 Nov; 6(11):1047-57. PMID: 16190985; PMCID: PMC2715427.
  49. Honczarenko M, Le Y, Swierkowski M, Ghiran I, Glodek AM, Silberstein LE. Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors. Stem Cells. 2006 Apr; 24(4):1030-41. PMID: 16253981.
    View in: PubMed
  50. Pilsczek FH, Nicholson-Weller A, Ghiran I. Phagocytosis of Salmonella montevideo by human neutrophils: immune adherence increases phagocytosis, whereas the bacterial surface determines the route of intracellular processing. J Infect Dis. 2005 Jul 15; 192(2):200-9. PMID: 15962214.
    View in: PubMed
  51. Repik A, Pincus SE, Ghiran I, Nicholson-Weller A, Asher DR, Cerny AM, Casey LS, Jones SM, Jones SN, Mohamed N, Klickstein LB, Spitalny G, Finberg RW. A transgenic mouse model for studying the clearance of blood-borne pathogens via human complement receptor 1 (CR1). Clin Exp Immunol. 2005 May; 140(2):230-40. PMID: 15807846; PMCID: PMC1809366.
  52. Otabor I, Tyagi S, Beurskens FJ, Ghiran I, Schwab P, Nicholson-Weller A, Klickstein LB. A role for lipid rafts in C1q-triggered O2- generation by human neutrophils. Mol Immunol. 2004 Jun; 41(2-3):185-90. PMID: 15159064.
    View in: PubMed
  53. Bandeira-Melo C, Perez SA, Melo RC, Ghiran I, Weller PF. EliCell assay for the detection of released cytokines from eosinophils. J Immunol Methods. 2003 May 01; 276(1-2):227-37. PMID: 12738376.
    View in: PubMed
  54. Ghiran I, Klickstein LB, Nicholson-Weller A. Calreticulin is at the surface of circulating neutrophils and uses CD59 as an adaptor molecule. J Biol Chem. 2003 Jun 06; 278(23):21024-31. PMID: 12646570.
    View in: PubMed
  55. Ghiran I, Tyagi SR, Klickstein LB, Nicholson-Weller A. Expression and function of C1q receptors and C1q binding proteins at the cell surface. Immunobiology. 2002 Sep; 205(4-5):407-20. PMID: 12396003.
    View in: PubMed
  56. Ghiran I, Barbashov SF, Klickstein LB, Tas SW, Jensenius JC, Nicholson-Weller A. Complement receptor 1/CD35 is a receptor for mannan-binding lectin. J Exp Med. 2000 Dec 18; 192(12):1797-808. PMID: 11120776; PMCID: PMC2213499.
  57. Bandeira-Melo C, Gillard G, Ghiran I, Weller PF. EliCell: a gel-phase dual antibody capture and detection assay to measure cytokine release from eosinophils. J Immunol Methods. 2000 Oct 20; 244(1-2):105-15. PMID: 11033023.
    View in: PubMed
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