Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Alan Cyril Mullen, M.D.,Ph.D.

Title
Institution
Department
Address
Phone
Fax

Biography
education and training
Penn, PhiladelphiaPhD2002Immunology
Penn, PhiladelphiaMD2004Medicine
Mass General Hospital, Boston2006Internal Medicine Residency
Mass General Hospital, Boston2011Fellowship in Gastroenterology

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01DK116999 (MULLEN, ALAN C) Jul 1, 2019 - May 31, 2023
    NIH
    Long noncoding RNAs regulating liver fibrosis
    Role: Principal Investigator
  2. R01HD092773 (MULLEN, ALAN C) Aug 25, 2017 - Apr 30, 2022
    NIH
    Long noncoding RNAs regulating endoderm differentiation
    Role: Principal Investigator
  3. R03DK104009 (MULLEN, ALAN C) Jan 1, 2015 - Dec 31, 2016
    NIH
    Role of long noncoding RNAs in human endodermal differentiation
    Role: Principal Investigator
  4. K08DK090122 (MULLEN, ALAN C) Mar 1, 2011 - Feb 29, 2016
    NIH
    Role of TGF-beta Signaling in Embryonic Stem Cell Maintenance and Endodermal Differe
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li W, Chen JY, Sun C, Sparks RP, Pantano L, Rahman RU, Moran SP, Pondick JV, Kirchner R, Wrobel D, Bieler M, Sauer A, Ho Sui SJ, Doerner JF, Rippmann JF, Mullen AC. Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. Elife. 2022 05 26; 11. PMID: 35617485; PMCID: PMC9135407.
    Citations:    Fields:    Translation:HumansCells
  2. Estevez M, Li R, Paul B, Daneshvar K, Mullen AC, Romerio F, Addepalli B. Identification and mapping of post-transcriptional modifications on the HIV-1 antisense transcript Ast in human cells. RNA. 2022 05; 28(5):697-710. PMID: 35168996; PMCID: PMC9014878.
    Citations:    Fields:    Translation:HumansCells
  3. Melendez J, Sieiro D, Salgado D, Morin V, Dejardin MJ, Zhou C, Mullen AC, Marcelle C. TGFß signalling acts as a molecular brake of myoblast fusion. Nat Commun. 2021 02 02; 12(1):749. PMID: 33531476; PMCID: PMC7854724.
    Citations: 10     Fields:    Translation:AnimalsCells
  4. Daneshvar K, Ardehali MB, Klein IA, Hsieh FK, Kratkiewicz AJ, Mahpour A, Cancelliere SOL, Zhou C, Cook BM, Li W, Pondick JV, Gupta SK, Moran SP, Young RA, Kingston RE, Mullen AC. lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nat Cell Biol. 2020 10; 22(10):1211-1222. PMID: 32895492; PMCID: PMC8008247.
    Citations: 35     Fields:    Translation:HumansCells
  5. Mahpour A, Mullen AC. Our emerging understanding of the roles of long non-coding RNAs in normal liver function, disease, and malignancy. JHEP Rep. 2021 Feb; 3(1):100177. PMID: 33294829.
    Citations: 14     
  6. Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). PMID: 32817366; PMCID: PMC7976849.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  7. Ufere NN, Donlan J, Waldman L, Patel A, Dienstag JL, Friedman LS, Corey KE, Hashemi N, Carolan P, Mullen AC, Thiim M, Bhan I, Nipp R, Greer J, Temel J, Chung RT, El-Jawahri A. Physicians' Perspectives on Palliative Care for Patients With End-Stage Liver Disease: A National Survey Study. Liver Transpl. 2019 06; 25(6):859-869. PMID: 30963669; PMCID: PMC6529275.
    Citations: 12     Fields:    Translation:Humans
  8. Ufere NN, Donlan J, Waldman L, Dienstag JL, Friedman LS, Corey KE, Hashemi N, Carolan P, Mullen AC, Thiim M, Bhan I, Nipp R, Greer JA, Temel JS, Chung RT, El-Jawahri A. Barriers to Use of Palliative Care and Advance Care Planning Discussions for Patients With End-Stage Liver Disease. Clin Gastroenterol Hepatol. 2019 11; 17(12):2592-2599. PMID: 30885884; PMCID: PMC6745282.
    Citations: 16     Fields:    Translation:Humans
  9. Zhou C, Molinie B, Daneshvar K, Pondick JV, Wang J, Van Wittenberghe N, Xing Y, Giallourakis CC, Mullen AC. Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs. Cell Rep. 2017 Aug 29; 20(9):2262-2276. PMID: 28854373.
    Citations: 165     Fields:    Translation:HumansCells
  10. Mullen AC, Wrana JL. TGF-ß Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7). PMID: 28108485; PMCID: PMC5495062.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  11. Chen JY, Newcomb B, Zhou C, Pondick JV, Ghoshal S, York SR, Motola DL, Coant N, Yi JK, Mao C, Tanabe KK, Bronova I, Berdyshev EV, Fuchs BC, Hannun Y, Chung RT, Mullen AC. Tricyclic Antidepressants Promote Ceramide Accumulation to Regulate Collagen Production in Human Hepatic Stellate Cells. Sci Rep. 2017 03 21; 7:44867. PMID: 28322247.
    Citations: 13     Fields:    Translation:HumansCells
  12. Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140. Sci Immunol. 2017 Mar 03; 2(9). PMID: 28783698.
    Citations: 20     Fields:    
  13. Daneshvar K, Pondick JV, Kim BM, Zhou C, York SR, Macklin JA, Abualteen A, Tan B, Sigova AA, Marcho C, Tremblay KD, Mager J, Choi MY, Mullen AC. DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells. Cell Rep. 2016 10 04; 17(2):353-365. PMID: 27705785.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  14. Molinie B, Wang J, Lim KS, Hillebrand R, Lu ZX, Van Wittenberghe N, Howard BD, Daneshvar K, Mullen AC, Dedon P, Xing Y, Giallourakis CC. m(6)A-LAIC-seq reveals the census and complexity of the m(6)A epitranscriptome. Nat Methods. 2016 08; 13(8):692-8. PMID: 27376769.
    Citations: 130     Fields:    Translation:HumansCells
  15. Zhou C, York SR, Chen JY, Pondick JV, Motola DL, Chung RT, Mullen AC. Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins. Genome Med. 2016 Mar 23; 8(1):31. PMID: 27007663; PMCID: PMC4804564.
    Citations: 26     Fields:    Translation:HumansCells
  16. Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, Wernig M, Mullen AC, Xing Y, Giallourakis CC, Chang HY. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 04; 15(6):707-19. PMID: 25456834.
    Citations: 478     Fields:    Translation:HumansAnimalsCells
  17. Mullen AC. Hippo tips the TGF-ß scale in favor of pluripotency. Cell Stem Cell. 2014 Jan 02; 14(1):6-8. PMID: 24388171; PMCID: PMC3941189.
    Citations: 13     Fields:    Translation:HumansCells
  18. Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2876-81. PMID: 23382218.
    Citations: 251     Fields:    Translation:HumansAnimalsCells
  19. Mullen AC, Orlando DA, Newman JJ, Lovén J, Kumar RM, Bilodeau S, Reddy J, Guenther MG, DeKoter RP, Young RA. Master transcription factors determine cell-type-specific responses to TGF-ß signaling. Cell. 2011 Oct 28; 147(3):565-76. PMID: 22036565.
    Citations: 319     Fields:    Translation:HumansAnimalsCells
  20. Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, Goldrath AW, Ahmed R, Reiner SL. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005 Dec; 6(12):1236-44. PMID: 16273099.
    Citations: 624     Fields:    Translation:HumansAnimalsCells
  21. Pearce EL, Mullen AC, Martins GA, Krawczyk CM, Hutchins AS, Zediak VP, Banica M, DiCioccio CB, Gross DA, Mao CA, Shen H, Cereb N, Yang SY, Lindsten T, Rossant J, Hunter CA, Reiner SL. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science. 2003 Nov 07; 302(5647):1041-3. PMID: 14605368.
    Citations: 465     Fields:    Translation:AnimalsCells
  22. Reiner SL, Mullen AC, Hutchins AS, Pearce EL. Helper T cell differentiation and the problem of cellular inheritance. Immunol Res. 2003; 27(2-3):463-8. PMID: 12857989.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  23. Hutchins AS, Mullen AC, Lee HW, Sykes KJ, High FA, Hendrich BD, Bird AP, Reiner SL. Gene silencing quantitatively controls the function of a developmental trans-activator. Mol Cell. 2002 Jul; 10(1):81-91. PMID: 12150909.
    Citations: 78     Fields:    Translation:AnimalsCells
  24. Mullen AC, Hutchins AS, High FA, Lee HW, Sykes KJ, Chodosh LA, Reiner SL. Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nat Immunol. 2002 Jul; 3(7):652-8. PMID: 12055627.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  25. Mullen AC, Hutchins AS, Villarino AV, Lee HW, High FA, Cereb N, Yang SY, Hua X, Reiner SL. Cell cycle controlling the silencing and functioning of mammalian activators. Curr Biol. 2001 Oct 30; 11(21):1695-9. PMID: 11696328.
    Citations: 16     Fields:    Translation:Cells
  26. Doyle AM, Mullen AC, Villarino AV, Hutchins AS, High FA, Lee HW, Thompson CB, Reiner SL. Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. J Exp Med. 2001 Oct 01; 194(7):893-902. PMID: 11581312; PMCID: PMC2193479.
    Citations: 25     Fields:    Translation:AnimalsCells
  27. Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 2001 Jun 08; 292(5523):1907-10. PMID: 11397944.
    Citations: 254     Fields:    Translation:AnimalsCells
  28. Masteller EL, Chuang E, Mullen AC, Reiner SL, Thompson CB. Structural analysis of CTLA-4 function in vivo. J Immunol. 2000 May 15; 164(10):5319-27. PMID: 10799894.
    Citations: 74     Fields:    Translation:AnimalsCells
  29. Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, Gajewski TF, Wang CR, Reiner SL. Helper T cell differentiation is controlled by the cell cycle. Immunity. 1998 Aug; 9(2):229-37. PMID: 9729043.
    Citations: 249     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Mullen's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (182)
Explore
_
Co-Authors (30)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.