Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael Bruce Yaffe, M.D., PH.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
Characterizing Cell-Specific Radiation Sensitization Induced by HDAC Inhibition
Summer, 05/29/12 - 08/17/12

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA226898 (YAFFE, MICHAEL B) Dec 7, 2018 - Nov 30, 2023
    NIH/NCI
    RNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer Therapies
    Role: Principal Investigator
  2. R35ES028374 (YAFFE, MICHAEL B) Sep 1, 2017 - Jul 31, 2025
    NIH/NIEHS
    Protein Kinase Signaling in the Genotoxic Stress Response
    Role: Principal Investigator
  3. R01CA185137 (CHAREST, ALAIN) Sep 1, 2014 - Aug 31, 2018
    NIH/NCI
    (PQB5)Molecular Wiring and Therapeutic Targeting of EGFR and PDGFR Signaling Netw
    Role: Co-Principal Investigator
  4. R01GM104047 (TURK, BENJAMIN E) Sep 10, 2013 - May 31, 2018
    NIH/NIGMS
    Modeling human phosphorylation networks through kinome-wide profiling
    Role: Co-Principal Investigator
  5. R21ES020466 (YAFFE, MICHAEL B) Jul 1, 2012 - Jun 30, 2014
    NIH/NIEHS
    Phospho-Binding Ligands and Substrates of BRCA1
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bandopadhayay P, Piccioni F, O'Rourke R, Ho P, Gonzalez EM, Buchan G, Qian K, Gionet G, Girard E, Coxon M, Rees MG, Brenan L, Dubois F, Shapira O, Greenwald NF, Pages M, Balboni Iniguez A, Paolella BR, Meng A, Sinai C, Roti G, Dharia NV, Creech A, Tanenbaum B, Khadka P, Tracy A, Tiv HL, Hong AL, Coy S, Rashid R, Lin JR, Cowley GS, Lam FC, Goodale A, Lee Y, Schoolcraft K, Vazquez F, Hahn WC, Tsherniak A, Bradner JE, Yaffe MB, Milde T, Pfister SM, Qi J, Schenone M, Carr SA, Ligon KL, Kieran MW, Santagata S, Olson JM, Gokhale PC, Jaffe JD, Root DE, Stegmaier K, Johannessen CM, Beroukhim R. Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nat Commun. 2019 06 03; 10(1):2400. PMID: 31160565.
    Citations:    
  2. van de Kooij B, Creixell P, van Vlimmeren A, Joughin B, Miller CJ, Haider N, Simpson CD, Linding R, Stambolic V, Turk BE, Yaffe MB. Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs. Elife. 2019 May 24; 8. PMID: 31124786.
    Citations:    
  3. Chen JK, Yaffe MB. Atlas Drugged. Cell. 2019 May 02; 177(4):803-805. PMID: 31051104.
    Citations:    
  4. Kim JH, Alderton A, Benvenisty N, Brandsten C, Firpo M, Harrison PW, Kawamata S, Kawase E, Kurtz A, Loring JF, Ludwig T, Man J, Mountford JC, Turner ML, Oh S, da Veiga Pereira L, Pranke P, Sheldon M, Steeg R, Sullivan S, Yaffe M, Zhou Q, Stacey GN. A report from a workshop of the International Stem Cell Banking Initiative, held in collaboration GAiT and the Harvard Stem Cell Institute, Boston 2017. Stem Cells. 2019 Apr 25. PMID: 31021472.
    Citations:    
  5. Miller CJ, Lou HJ, Simpson C, van de Kooij B, Ha BH, Fisher OS, Pirman NL, Boggon TJ, Rinehart J, Yaffe MB, Linding R, Turk BE. Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output. PLoS Biol. 2019 Mar; 17(3):e2006540. PMID: 30897078.
    Citations:    
  6. Kasikara C, Davra V, Calianese D, Geng K, Spires TE, Quigley M, Wichroski M, Sriram G, Suarez-Lopez L, Yaffe MB, Kotenko SV, De Lorenzo MS, Birge RB. Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer. Cancer Res. 2019 May 15; 79(10):2669-2683. PMID: 30877108.
    Citations:    
  7. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Correction: Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol. 2019 03; 12(2):580. PMID: 30514887.
    Citations:    Fields:    
  8. Patterson JC, Joughin BA, van de Kooij B, Lim DC, Lauffenburger DA, Yaffe MB. ROS and Oxidative Stress Are Elevated in Mitosis during Asynchronous Cell Cycle Progression and Are Exacerbated by Mitotic Arrest. Cell Syst. 2019 Feb 27; 8(2):163-167.e2. PMID: 30797774.
    Citations:    
  9. Rohani N, Hao L, Alexis MS, Joughin BA, Krismer K, Moufarrej MN, Soltis AR, Lauffenburger DA, Yaffe MB, Burge CB, Bhatia SN, Gertler FB. Acidification of Tumor at Stromal Boundaries Drives Transcriptome Alterations Associated with Aggressive Phenotypes. Cancer Res. 2019 Apr 15; 79(8):1952-1966. PMID: 30755444.
    Citations:    
  10. Hwang JH, Kim AR, Kim KM, Il Park J, Oh HT, Moon SA, Byun MR, Jeong H, Kim HK, Yaffe MB, Hwang ES, Hong JH. TAZ couples Hippo/Wnt signalling and insulin sensitivity through Irs1 expression. Nat Commun. 2019 01 24; 10(1):421. PMID: 30679431.
    Citations:    Fields:    
  11. Yaffe MB. Why geneticists stole cancer research even though cancer is primarily a signaling disease. Sci Signal. 2019 Jan 22; 12(565). PMID: 30670634.
    Citations:    Fields:    
  12. Barrett CD, Moore HB, Kong YW, Chapman MP, Sriram G, Lim D, Moore EE, Yaffe MB. Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner. J Trauma Acute Care Surg. 2019 Jan; 86(1):101-107. PMID: 30575685.
    Citations:    Fields:    
  13. Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K. A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils. J Trauma Acute Care Surg. 2018 Nov; 85(5):936-943. PMID: 29787548.
    Citations: 1     Fields:    
  14. Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB. Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Syst. 2018 Oct 24; 7(4):371-383.e4. PMID: 30243563.
    Citations:    Fields:    
  15. Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB. Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Clin Exp Immunol. 2018 Oct; 194(1):103-117. PMID: 30260475.
    Citations:    Fields:    
  16. Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR. Histidine N(t)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg Med Chem Lett. 2018 10 15; 28(19):3202-3205. PMID: 30174151.
    Citations:    Fields:    
  17. Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond DC, Yaffe MB, Raue A. Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway. Sci Signal. 2018 Jul 24; 11(540). PMID: 30042127.
    Citations:    Fields:    
  18. Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat Commun. 2018 05 18; 9(1):1991. PMID: 29777137.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4236-E4244. PMID: 29666270.
    Citations:    Fields:    Translation:AnimalsCells
  20. Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC. TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome. J Clin Endocrinol Metab. 2018 03 01; 103(3):839-852. PMID: 29294041.
    Citations:    Fields:    Translation:Humans
  21. Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT. RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors. Bioeng Transl Med. 2018 01; 3(1):26-36. PMID: 29376131.
    Citations:    
  22. Yaffe MB. Predicting the future of signaling for 2018. Sci Signal. 2018 01 02; 11(511). PMID: 29295956.
    Citations:    Fields:    
  23. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 12; 83(6):1053-1061. PMID: 28837538.
    Citations:    Fields:    Translation:HumansCells
  24. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol. 2018 05; 11(3):703-715. PMID: 29139475.
    Citations: 1     Fields:    Translation:AnimalsCells
  25. Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell. 2017 10 09; 32(4):411-426.e11. PMID: 28966034.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Yaffe MB. Highlight: Understanding radiation sialadenitis. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588084.
    Citations:    Fields:    
  27. Yaffe M. Highlight: A new way to block the development of asthma from dust mites. Sci Signal. 2017 Apr 18; 10(475). PMID: 28420752.
    Citations:    Fields:    Translation:HumansAnimals
  28. Yaffe MB, VanHook AM. Science Signaling Podcast for 14 March 2017: The Cancer Moonshot. Sci Signal. 2017 Mar 14; 10(470). PMID: 28292953.
    Citations:    Fields:    
  29. Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP. Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents. J Am Chem Soc. 2017 03 01; 139(8):3033-3044. PMID: 28166401.
    Citations: 3     Fields:    Translation:HumansCells
  30. Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harb Perspect Biol. 2016 Jun 01; 8(6). PMID: 27252361.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  31. Lam FC, Yaffe MB. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Cancer Cell. 2016 Apr 11; 29(4):435-436. PMID: 27070697.
    Citations: 4     Fields:    Translation:Humans
  32. Yaffe MB, Gough NR. Leveraging signaling research to understand and treat disease. Sci Signal. 2016 Mar 29; 9(421):eg4. PMID: 27025875.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Dec 14; 28(6):831. PMID: 28843280.
    Citations: 1     Fields:    
  34. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Nov 09; 28(5):623-637. PMID: 26602816.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR. Neighbor-directed histidine N (t)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers. 2015 Nov; 104(6):663-73. PMID: 26152807.
    Citations: 3     Fields:    Translation:Cells
  36. Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock. 2015 Aug; 44(2):128-36. PMID: 26009816.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT. Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle. Clin Cancer Res. 2015 Oct 01; 21(19):4410-9. PMID: 26034127.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  38. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. J Biomol Screen. 2015 Sep; 20(8):985-97. PMID: 25918037.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  39. Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 2015 Apr 13; 27(4):489-501. PMID: 25873172.
    Citations: 23     Fields:    Translation:AnimalsCells
  40. Naegle K, Gough NR, Yaffe MB. Criteria for biological reproducibility: what does "n" mean? Sci Signal. 2015 Apr 07; 8(371):fs7. PMID: 25852186.
    Citations: 1     Fields:    Translation:HumansAnimals
  41. Yaffe MB. Reproducibility in science. Sci Signal. 2015 Apr 07; 8(371):eg5. PMID: 25852185.
    Citations: 4     Fields:    Translation:HumansAnimals
  42. Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM. Engineered bromodomains to explore the acetylproteome. Proteomics. 2015 May; 15(9):1470-5. PMID: 25641834.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  43. Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods Mol Biol. 2015; 1278:57-75. PMID: 25859943.
    Citations: 6     Fields:    Translation:Cells
  44. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell. 2015 Jan 08; 57(1):95-107. PMID: 25482511.
    Citations: 52     Fields:    Translation:AnimalsCells
  45. Gates JD, Arabian S, Biddinger P, Blansfield J, Burke P, Chung S, Fischer J, Friedman F, Gervasini A, Goralnick E, Gupta A, Larentzakis A, McMahon M, Mella J, Michaud Y, Mooney D, Rabinovici R, Sweet D, Ulrich A, Velmahos G, Weber C, Yaffe MB. The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster. Ann Surg. 2014 Dec; 260(6):960-6. PMID: 25386862.
    Citations: 8     Fields:    Translation:Humans
  46. Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers. 2014 Nov; 102(6):444-55. PMID: 25283071.
    Citations: 11     Fields:    Translation:HumansCells
  47. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2014 Sep 18; 21(9):1254. PMID: 25368881.
    Citations:    Fields:    
  48. Peterson LB, Yaffe MB, Imperiali B. Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs. Biochemistry. 2014 Sep 16; 53(36):5771-8. PMID: 25153342.
    Citations: 1     Fields:    Translation:Cells
  49. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28; 158(5):1094-1109. PMID: 25171410.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  50. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11; 26(2):222-34. PMID: 25117710.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  51. Liu B, Yang K, Yaffe M, Chen J. TH-A-18A-01: Innovation in Clinical Breast Imaging. Med Phys. 2014 Jun; 41(6):532-533. PMID: 28037992.
    Citations:    
  52. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014 May 13; 7(325):ra44. PMID: 24825919.
    Citations: 27     Fields:    Translation:Animals
  53. Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation. Cell Death Differ. 2014 Jun; 21(6):854-63. PMID: 24510127.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  54. Sudol M, Yaffe MB. Death of a Titan. Sci Signal. 2013 Dec 17; 6(306):eg6. PMID: 24345678.
    Citations:    Fields:    
  55. Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep. 2013 Nov 27; 5(4):868-77. PMID: 24239348.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  56. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. PMID: 24129568.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  57. Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2013 Oct 24; 20(10):1255-64. PMID: 24120332.
    Citations: 3     Fields:    Translation:HumansCells
  58. Reinhardt HC, Yaffe MB. Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol. 2013 Sep; 14(9):563-80. PMID: 23969844.
    Citations: 71     Fields:    Translation:HumansCells
  59. Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26; 341(6144):1236566. PMID: 23888043.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  60. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50. PMID: 23728299.
    Citations: 76     Fields:    Translation:HumansCells
  61. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
    Citations: 7     Fields:    Translation:Animals
  62. Yaffe M. Newsmaker interview: Michael Yaffe. Boston bombing victims aided by biologist-surgeon. Interview with Trisha Gura. Science. 2013 May 10; 340(6133):671. PMID: 23661732.
    Citations:    Fields:    Translation:Humans
  63. Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR, Winey M, Smerdon SJ, Yaffe MB, Amon A. Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science. 2013 May 17; 340(6134):871-5. PMID: 23579499.
    Citations: 28     Fields:    Translation:AnimalsCells
  64. Yaffe MB. The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment. Sci Signal. 2013 Apr 02; 6(269):pe13. PMID: 23550209.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  65. Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg Med Chem. 2013 May 01; 21(9):2623-34. PMID: 23498919.
    Citations: 9     Fields:    Translation:HumansCells
  66. Weingeist DM, Ge J, Wood DK, Mutamba JT, Huang Q, Rowland EA, Yaffe MB, Floyd S, Engelward BP. Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle. 2013 Mar 15; 12(6):907-15. PMID: 23422001.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  67. Yaffe MB, Gough NR. 2012: Signaling breakthroughs of the year. Sci Signal. 2013 Jan 01; 6(256):eg1. PMID: 23281367.
    Citations:    Fields:    Translation:Cells
  68. Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Mol Biosyst. 2012 Oct; 8(10):2771-82. PMID: 22851037.
    Citations: 6     Fields:    Translation:HumansCells
  69. Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integr Biol (Camb). 2012 Oct; 4(10):1237-55. PMID: 22892544.
    Citations: 11     Fields:    Translation:HumansCells
  70. Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2574-83. PMID: 22889908.
    Citations: 4     Fields:    Translation:HumansCells
  71. Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J. 2012 Oct 17; 31(20):3961-75. PMID: 22909821.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  72. Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14381-6. PMID: 22908299.
    Citations: 21     Fields:    Translation:HumansCells
  73. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. PMID: 22761577.
    Citations: 56     Fields:    Translation:HumansAnimals
  74. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283.
    Citations: 204     Fields:    Translation:HumansCells
  75. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1. Chembiochem. 2012 Jun 18; 13(9):1291-6. PMID: 22570300.
    Citations: 12     Fields:    Translation:Cells
  76. Kholodenko B, Yaffe MB, Kolch W. Computational approaches for analyzing information flow in biological networks. Sci Signal. 2012 Apr 17; 5(220):re1. PMID: 22510471.
    Citations: 56     Fields:    Translation:Cells
  77. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol. 2012 May 18; 7(5):805-10. PMID: 22292814.
    Citations: 21     Fields:    Translation:HumansCells
  78. Mohammad DH, Yaffe MB. Fixin' to divide. Mol Cell. 2012 Feb 10; 45(3):273-5. PMID: 22325348.
    Citations:    Fields:    Translation:HumansCells
  79. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012 Jan 31; 8:568. PMID: 22294094.
    Citations: 28     Fields:    Translation:HumansCells
  80. Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):929-34. PMID: 22223660.
    Citations: 45     Fields:    Translation:HumansCells
  81. Morandell S, Yaffe MB. Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy. Prog Mol Biol Transl Sci. 2012; 110:289-314. PMID: 22749150.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  82. Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, Yaffe MB, Strano S, Blandino G, Di Agostino S. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle. 2011 Dec 15; 10(24):4330-40. PMID: 22134238.
    Citations: 32     Fields:    Translation:HumansCells
  83. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011 Dec 23; 44(6):878-92. PMID: 22137581.
    Citations: 78     Fields:    Translation:HumansCells
  84. Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM. Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal. 2011 Nov 08; 4(198):rs12. PMID: 22067460.
    Citations: 37     Fields:    Translation:HumansCells
  85. Gardino AK, Yaffe MB. 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol. 2011 Sep; 22(7):688-95. PMID: 21945648.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  86. Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics. 2011 Nov; 10(11):M111.008540. PMID: 21857030.
    Citations: 29     Fields:    Translation:HumansCells
  87. Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. PLoS Comput Biol. 2011 Jul; 7(7):e1002119. PMID: 21799663.
    Citations: 12     Fields:    Translation:Humans
  88. Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol. 2011 Jul 17; 7(9):595-601. PMID: 21765407.
    Citations: 33     Fields:    Translation:HumansCells
  89. Cannell IG, Yaffe MB. Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network. Crit Care Med. 2011 Jul; 39(7):1836-7. PMID: 21685754.
    Citations:    Fields:    Translation:HumansCells
  90. Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB. Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal. 2011 Jun 28; 4(179):ra42. PMID: 21712545.
    Citations: 68