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Michael Bruce Yaffe, M.D., PH.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Characterizing Cell-Specific Radiation Sensitization Induced by HDAC Inhibition
Summer, 05/29/12 - 08/17/12

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R35ES028374 (YAFFE, MICHAEL B) Sep 1, 2017 - Jul 31, 2025
    NIH/NIEHS
    Protein Kinase Signaling in the Genotoxic Stress Response
    Role: Principal Investigator
  2. R01CA185137 (CHAREST, ALAIN) Sep 1, 2014 - Aug 31, 2018
    NIH/NCI
    (PQB5)Molecular Wiring and Therapeutic Targeting of EGFR and PDGFR Signaling Netw
    Role: Co-Principal Investigator
  3. R01GM104047 (TURK, BENJAMIN E) Sep 10, 2013 - May 31, 2018
    NIH/NIGMS
    Modeling human phosphorylation networks through kinome-wide profiling
    Role: Co-Principal Investigator
  4. R21ES020466 (YAFFE, MICHAEL B) Jul 1, 2012 - Jun 30, 2014
    NIH/NIEHS
    Phospho-Binding Ligands and Substrates of BRCA1
    Role: Principal Investigator
  5. R21NS063917 (YAFFE, MICHAEL B) Jun 15, 2008 - May 31, 2010
    NIH/NINDS
    High-content screening for modifiers of the DNA damage response
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Barrett CD, Hsu AT, Ellson CD, Y Miyazawa B, Kong YW, Greenwood JD, Dhara S, Neal MD, Sperry JL, Park MS, Cohen MJ, Zuckerbraun BS, Yaffe MB. Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. Clin Exp Immunol. 2018 Oct; 194(1):103-117. PMID: 30260475.
    View in: PubMed
  2. Creixell P, Pandey JP, Palmeri A, Bhattacharyya M, Creixell M, Ranganathan R, Pincus D, Yaffe MB. Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity. Cell Syst. 2018 Sep 05. PMID: 30243563.
    View in: PubMed
  3. Hymel D, Grant RA, Tsuji K, Yaffe MB, Burke TR. Histidine N(t)-cyclized macrocycles as a new genre of polo-like kinase 1 polo-box domain-binding inhibitors. Bioorg Med Chem Lett. 2018 Oct 15; 28(19):3202-3205. PMID: 30174151.
    View in: PubMed
  4. Alkan O, Schoeberl B, Shah M, Koshkaryev A, Heinemann T, Drummond DC, Yaffe MB, Raue A. Modeling chemotherapy-induced stress to identify rational combination therapies in the DNA damage response pathway. Sci Signal. 2018 Jul 24; 11(540). PMID: 30042127.
    View in: PubMed
  5. Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT. Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. Nat Commun. 2018 May 18; 9(1):1991. PMID: 29777137.
    View in: PubMed
  6. Kaczmarek E, Hauser CJ, Kwon WY, Rica I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich M, Itagaki K. A SUBSET OF FIVE HUMAN MITOCHONDRIAL FORMYL PEPTIDES MIMICS BACTERIAL PEPTIDES AND FUNCTIONALLY DEACTIVATES HUMAN NEUETROPHILS. J Trauma Acute Care Surg. 2018 May 04. PMID: 29787548.
    View in: PubMed
  7. Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4236-E4244. PMID: 29666270.
    View in: PubMed
  8. Moya CM, Zaballos MA, Garzón L, Luna C, Simón R, Yaffe MB, Gallego E, Santisteban P, Moreno JC. TAZ/WWTR1 Mediates the Pulmonary Effects of NKX2-1 Mutations in Brain-Lung-Thyroid Syndrome. J Clin Endocrinol Metab. 2018 03 01; 103(3):839-852. PMID: 29294041.
    View in: PubMed
  9. Dreaden EC, Kong YW, Quadir MA, Correa S, Suárez-López L, Barberio AE, Hwang MK, Shi AC, Oberlton B, Gallagher PN, Shopsowitz KE, Elias KM, Yaffe MB, Hammond PT. RNA-Peptide nanoplexes drug DNA damage pathways in high-grade serous ovarian tumors. Bioeng Transl Med. 2018 Jan; 3(1):26-36. PMID: 29376131.
    View in: PubMed
  10. Yaffe MB. Predicting the future of signaling for 2018. Sci Signal. 2018 Jan 02; 11(511). PMID: 29295956.
    View in: PubMed
  11. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human neutrophil elastase mediates fibrinolysis shutdown through competitive degradation of plasminogen and generation of angiostatin. J Trauma Acute Care Surg. 2017 Dec; 83(6):1053-1061. PMID: 28837538.
    View in: PubMed
  12. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol. 2018 May; 11(3):703-715. PMID: 29139475.
    View in: PubMed
  13. Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell. 2017 10 09; 32(4):411-426.e11. PMID: 28966034.
    View in: PubMed
  14. Yaffe MB. Highlight: Understanding radiation sialadenitis. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588084.
    View in: PubMed
  15. Yaffe M. Highlight: A new way to block the development of asthma from dust mites. Sci Signal. 2017 Apr 18; 10(475). PMID: 28420752.
    View in: PubMed
  16. Yaffe MB, VanHook AM. Science Signaling Podcast for 14 March 2017: The Cancer Moonshot. Sci Signal. 2017 Mar 14; 10(470). PMID: 28292953.
    View in: PubMed
  17. Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP. Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents. J Am Chem Soc. 2017 03 01; 139(8):3033-3044. PMID: 28166401.
    View in: PubMed
  18. Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harb Perspect Biol. 2016 Jun 01; 8(6). PMID: 27252361.
    View in: PubMed
  19. Lam FC, Yaffe MB. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Cancer Cell. 2016 Apr 11; 29(4):435-436. PMID: 27070697.
    View in: PubMed
  20. Yaffe MB, Gough NR. Leveraging signaling research to understand and treat disease. Sci Signal. 2016 Mar 29; 9(421):eg4. PMID: 27025875.
    View in: PubMed
  21. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Dec 14; 28(6):831. PMID: 28843280.
    View in: PubMed
  22. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Nov 09; 28(5):623-637. PMID: 26602816.
    View in: PubMed
  23. Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR. Neighbor-directed histidine N (t)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers. 2015 Nov; 104(6):663-73. PMID: 26152807.
    View in: PubMed
  24. Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock. 2015 Aug; 44(2):128-36. PMID: 26009816; PMCID: PMC4830084.
    View in: PubMed, PubMed Central
  25. Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT. Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle. Clin Cancer Res. 2015 Oct 01; 21(19):4410-9. PMID: 26034127; PMCID: PMC4624301 [Available on 10/01/16].
    View in: PubMed, PubMed Central
  26. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. J Biomol Screen. 2015 Sep; 20(8):985-97. PMID: 25918037.
    View in: PubMed
  27. Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 2015 Apr 13; 27(4):489-501. PMID: 25873172; PMCID: PMC4398916.
    View in: PubMed, PubMed Central
  28. Naegle K, Gough NR, Yaffe MB. Criteria for biological reproducibility: what does "n" mean? Sci Signal. 2015 Apr 07; 8(371):fs7. PMID: 25852186.
    View in: PubMed
  29. Yaffe MB. Reproducibility in science. Sci Signal. 2015 Apr 07; 8(371):eg5. PMID: 25852185.
    View in: PubMed
  30. Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM. Engineered bromodomains to explore the acetylproteome. Proteomics. 2015 May; 15(9):1470-5. PMID: 25641834; PMCID: PMC4535431.
    View in: PubMed, PubMed Central
  31. Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods Mol Biol. 2015; 1278:57-75. PMID: 25859943; PMCID: PMC4435844.
    View in: PubMed, PubMed Central
  32. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell. 2015 Jan 08; 57(1):95-107. PMID: 25482511; PMCID: PMC4289430.
    View in: PubMed, PubMed Central
  33. Gates JD, Arabian S, Biddinger P, Blansfield J, Burke P, Chung S, Fischer J, Friedman F, Gervasini A, Goralnick E, Gupta A, Larentzakis A, McMahon M, Mella J, Michaud Y, Mooney D, Rabinovici R, Sweet D, Ulrich A, Velmahos G, Weber C, Yaffe MB. The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster. Ann Surg. 2014 Dec; 260(6):960-6. PMID: 25386862.
    View in: PubMed
  34. Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers. 2014 Nov; 102(6):444-55. PMID: 25283071.
    View in: PubMed
  35. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2014 Sep 18; 21(9):1254. PMID: 25368881; PMCID: PMC4379504.
    View in: PubMed, PubMed Central
  36. Peterson LB, Yaffe MB, Imperiali B. Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs. Biochemistry. 2014 Sep 16; 53(36):5771-8. PMID: 25153342; PMCID: PMC4165445.
    View in: PubMed, PubMed Central
  37. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28; 158(5):1094-1109. PMID: 25171410; PMCID: PMC4250222.
    View in: PubMed, PubMed Central
  38. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11; 26(2):222-34. PMID: 25117710; PMCID: PMC4169234.
    View in: PubMed, PubMed Central
  39. Liu B, Yang K, Yaffe M, Chen J. TH-A-18A-01: Innovation in Clinical Breast Imaging. Med Phys. 2014 Jun; 41(6):532-533. PMID: 28037992.
    View in: PubMed
  40. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014 May 13; 7(325):ra44. PMID: 24825919; PMCID: PMC4138219.
    View in: PubMed, PubMed Central
  41. Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation. Cell Death Differ. 2014 Jun; 21(6):854-63. PMID: 24510127; PMCID: PMC4013522.
    View in: PubMed, PubMed Central
  42. Sudol M, Yaffe MB. Death of a Titan. Sci Signal. 2013 Dec 17; 6(306):eg6. PMID: 24345678.
    View in: PubMed
  43. Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep. 2013 Nov 27; 5(4):868-77. PMID: 24239348; PMCID: PMC3962842.
    View in: PubMed, PubMed Central
  44. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. PMID: 24129568; PMCID: PMC3843107.
    View in: PubMed, PubMed Central
  45. Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2013 Oct 24; 20(10):1255-64. PMID: 24120332.
    View in: PubMed
  46. Reinhardt HC, Yaffe MB. Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol. 2013 Sep; 14(9):563-80. PMID: 23969844.
    View in: PubMed
  47. Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26; 341(6144):1236566. PMID: 23888043; PMCID: PMC3771538.
    View in: PubMed, PubMed Central
  48. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50. PMID: 23728299; PMCID: PMC3683358.
    View in: PubMed, PubMed Central
  49. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
    View in: PubMed
  50. Yaffe M. Newsmaker interview: Michael Yaffe. Boston bombing victims aided by biologist-surgeon. Interview with Trisha Gura. Science. 2013 May 10; 340(6133):671. PMID: 23661732.
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  51. Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR, Winey M, Smerdon SJ, Yaffe MB, Amon A. Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science. 2013 May 17; 340(6134):871-5. PMID: 23579499; PMCID: PMC3884217.
    View in: PubMed, PubMed Central
  52. Yaffe MB. The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment. Sci Signal. 2013 Apr 02; 6(269):pe13. PMID: 23550209.
    View in: PubMed
  53. Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg Med Chem. 2013 May 01; 21(9):2623-34. PMID: 23498919.
    View in: PubMed
  54. Weingeist DM, Ge J, Wood DK, Mutamba JT, Huang Q, Rowland EA, Yaffe MB, Floyd S, Engelward BP. Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle. 2013 Mar 15; 12(6):907-15. PMID: 23422001; PMCID: PMC3637349.
    View in: PubMed, PubMed Central
  55. Yaffe MB, Gough NR. 2012: Signaling breakthroughs of the year. Sci Signal. 2013 Jan 01; 6(256):eg1. PMID: 23281367.
    View in: PubMed
  56. Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Mol Biosyst. 2012 Oct; 8(10):2771-82. PMID: 22851037; PMCID: PMC3501258.
    View in: PubMed, PubMed Central
  57. Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integr Biol (Camb). 2012 Oct; 4(10):1237-55. PMID: 22892544; PMCID: PMC3574819.
    View in: PubMed, PubMed Central
  58. Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2574-83. PMID: 22889908; PMCID: PMC3415838.
    View in: PubMed, PubMed Central
  59. Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J. 2012 Oct 17; 31(20):3961-75. PMID: 22909821; PMCID: PMC3474921.
    View in: PubMed, PubMed Central
  60. Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14381-6. PMID: 22908299; PMCID: PMC3437875.
    View in: PubMed, PubMed Central
  61. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. PMID: 22761577; PMCID: PMC3386190.
    View in: PubMed, PubMed Central
  62. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283; PMCID: PMC3501264.
    View in: PubMed, PubMed Central
  63. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1. Chembiochem. 2012 Jun 18; 13(9):1291-6. PMID: 22570300; PMCID: PMC4536914.
    View in: PubMed, PubMed Central
  64. Kholodenko B, Yaffe MB, Kolch W. Computational approaches for analyzing information flow in biological networks. Sci Signal. 2012 Apr 17; 5(220):re1. PMID: 22510471.
    View in: PubMed
  65. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol. 2012 May 18; 7(5):805-10. PMID: 22292814.
    View in: PubMed
  66. Mohammad DH, Yaffe MB. Fixin' to divide. Mol Cell. 2012 Feb 10; 45(3):273-5. PMID: 22325348; PMCID: PMC3501254.
    View in: PubMed, PubMed Central
  67. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012 Jan 31; 8:568. PMID: 22294094; PMCID: PMC3296916.
    View in: PubMed, PubMed Central
  68. Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):929-34. PMID: 22223660; PMCID: PMC3271913.
    View in: PubMed, PubMed Central
  69. Morandell S, Yaffe MB. Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy. Prog Mol Biol Transl Sci. 2012; 110:289-314. PMID: 22749150.
    View in: PubMed
  70. Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, Yaffe MB, Strano S, Blandino G, Di Agostino S. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle. 2011 Dec 15; 10(24):4330-40. PMID: 22134238.
    View in: PubMed
  71. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011 Dec 23; 44(6):878-92. PMID: 22137581; PMCID: PMC3246132.
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  72. Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM. Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal. 2011 Nov 08; 4(198):rs12. PMID: 22067460; PMCID: PMC4206221.
    View in: PubMed, PubMed Central
  73. Gardino AK, Yaffe MB. 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol. 2011 Sep; 22(7):688-95. PMID: 21945648; PMCID: PMC3507455.
    View in: PubMed, PubMed Central
  74. Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics. 2011 Nov; 10(11):M111.008540. PMID: 21857030; PMCID: PMC3226402.
    View in: PubMed, PubMed Central
  75. Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. PLoS Comput Biol. 2011 Jul; 7(7):e1002119. PMID: 21799663; PMCID: PMC3140961.
    View in: PubMed, PubMed Central
  76. Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol. 2011 Jul 17; 7(9):595-601. PMID: 21765407.
    View in: PubMed
  77. Cannell IG, Yaffe MB. Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network. Crit Care Med. 2011 Jul; 39(7):1836-7. PMID: 21685754; PMCID: PMC3677698.
    View in: PubMed, PubMed Central
  78. Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB. Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal. 2011 Jun 28; 4(179):ra42. PMID: 21712545.
    View in: PubMed
  79. Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10; 332(6035):1317-22. PMID: 21659604; PMCID: PMC3177140.
    View in: PubMed, PubMed Central
  80. Passaperuma K, Plewes DB, Causer P, Hill KA, Messner SJ, Wong J, Jong RA, Wright F, Yaffe M, Ramsay E, Balasingham S, Verity L, Eisen A, Curpen B, Shumak R, Narod S, Warner E. Long-term results of the Toronto magnetic resonance imaging (MRI) breast surveillance study of women with BRCA1 or BRCA2 mutations. J Clin Oncol. 2011 May 20; 29(15_suppl):542. PMID: 28021507.
    View in: PubMed
  81. Gough NR, Yaffe MB. Focus issue: conquering the data mountain. Sci Signal. 2011 Feb 15; 4(160):eg2. PMID: 21325201.
    View in: PubMed
  82. Reinhardt HC, Cannell IG, Morandell S, Yaffe MB. Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle. 2011 Jan 01; 10(1):23-7. PMID: 21173571; PMCID: PMC3048069.
    View in: PubMed, PubMed Central
  83. Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ. Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure. 2010 Dec 08; 18(12):1587-95. PMID: 21134638.
    View in: PubMed
  84. Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell. 2010 Oct 08; 40(1):34-49. PMID: 20932473; PMCID: PMC3030122.
    View in: PubMed, PubMed Central
  85. Yaffe MB. Looking ahead to the past. Sci Signal. 2010 Sep 07; 3(138):eg7. PMID: 20823400.
    View in: PubMed
  86. Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L. 3rd US-EU workshop: systems level understanding of DNA damage responses. Mutat Res. 2010 Oct 13; 692(1-2):53-60. PMID: 20727903; PMCID: PMC2948618.
    View in: PubMed, PubMed Central
  87. Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics. 2010 Nov; 9(11):2558-70. PMID: 20631208; PMCID: PMC2984232.
    View in: PubMed, PubMed Central
  88. Jiang Y, Puliyappadamba VT, Zhang L, Wu W, Wali A, Yaffe MB, Fontana JA, Rishi AK. A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1. J Mol Signal. 2010 Jul 01; 5:7. PMID: 20594350; PMCID: PMC2904743.
    View in: PubMed, PubMed Central
  89. van Vugt MA, Yaffe MB. Cell cycle re-entry mechanisms after DNA damage checkpoints: giving it some gas to shut off the breaks! Cell Cycle. 2010 Jun 01; 9(11):2097-101. PMID: 20505366.
    View in: PubMed
  90. Jeong H, Bae S, An SY, Byun MR, Hwang JH, Yaffe MB, Hong JH, Hwang ES. TAZ as a novel enhancer of MyoD-mediated myogenic differentiation. FASEB J. 2010 Sep; 24(9):3310-20. PMID: 20466877.
    View in: PubMed
  91. Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res. 2010 May 01; 70(9):3843-50. PMID: 20406974; PMCID: PMC2862125.
    View in: PubMed, PubMed Central
  92. Wen J, Wilker EW, Yaffe MB, Jensen KF. Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation. Anal Chem. 2010 Feb 15; 82(4):1253-60. PMID: 20092256; PMCID: PMC2826279.
    View in: PubMed, PubMed Central
  93. van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010 Jan 26; 8(1):e1000287. PMID: 20126263; PMCID: PMC2811157.
    View in: PubMed, PubMed Central
  94. Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M. Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. J Biol Chem. 2010 Feb 05; 285(6):4185-94. PMID: 19996099; PMCID: PMC2823557.
    View in: PubMed, PubMed Central
  95. Yaffe MB. Living by the numbers. Sci Signal. 2009 Dec 01; 2(99):eg15. PMID: 19952368.
    View in: PubMed
  96. Blandino G, Shaul Y, Strano S, Sudol M, Yaffe M. The Hippo tumor suppressor pathway: a brainstorming workshop. Sci Signal. 2009 Nov 03; 2(95):mr6. PMID: 19887678.
    View in: PubMed
  97. Reinhardt HC, Jiang H, Hemann MT, Yaffe MB. Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle. 2009 Oct 01; 8(19):3112-9. PMID: 19755856; PMCID: PMC3057180.
    View in: PubMed, PubMed Central
  98. Yaffe MB. Re-reviewing peer review. Sci Signal. 2009 Aug 25; 2(85):eg11. PMID: 19706869.
    View in: PubMed
  99. Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009 Aug; 60(8):2314-24. PMID: 19644878; PMCID: PMC3080016.
    View in: PubMed, PubMed Central
  100. Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 2009 Aug 15; 23(16):1895-909. PMID: 19608766; PMCID: PMC2725944.
    View in: PubMed, PubMed Central
  101. Yun SM, Moulaei T, Lim D, Bang JK, Park JE, Shenoy SR, Liu F, Kang YH, Liao C, Soung NK, Lee S, Yoon DY, Lim Y, Lee DH, Otaka A, Appella E, McMahon JB, Nicklaus MC, Burke TR, Yaffe MB, Wlodawer A, Lee KS. Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol. 2009 Aug; 16(8):876-82. PMID: 19597481.
    View in: PubMed
  102. Yaffe MB. Challenging times. Sci Signal. 2009 Jun 30; 2(77):eg8. PMID: 19567911.
    View in: PubMed
  103. Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009 Jun; 8(6):1666-75. PMID: 19509266; PMCID: PMC2740925.
    View in: PubMed, PubMed Central
  104. Mohammad DH, Yaffe MB. 14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst). 2009 Sep 02; 8(9):1009-17. PMID: 19481982; PMCID: PMC3263375.
    View in: PubMed, PubMed Central
  105. Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009 May 05; 7(5):e1000111. PMID: 19468302; PMCID: PMC2680336.
    View in: PubMed, PubMed Central
  106. van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS One. 2009; 4(4):e5282. PMID: 19390576; PMCID: PMC2668763.
    View in: PubMed, PubMed Central
  107. Kishi K, van Vugt MA, Okamoto K, Hayashi Y, Yaffe MB. Functional dynamics of Polo-like kinase 1 at the centrosome. Mol Cell Biol. 2009 Jun; 29(11):3134-50. PMID: 19307309; PMCID: PMC2682011.
    View in: PubMed, PubMed Central
  108. Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol. 2009 Apr; 21(2):245-55. PMID: 19230643; PMCID: PMC2699687.
    View in: PubMed, PubMed Central
  109. Yaffe MB. Freedom of materials. Sci Signal. 2009 Jan 27; 2(55):eg2. PMID: 19176512.
    View in: PubMed
  110. Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G. Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):785-90. PMID: 19139404; PMCID: PMC2630102.
    View in: PubMed, PubMed Central
  111. Yaffe MB. Beyond microarrays. Sci Signal. 2008 Dec 23; 1(51):eg11. PMID: 19109235.
    View in: PubMed
  112. Edbauer D, Cheng D, Batterton MN, Wang CF, Duong DM, Yaffe MB, Peng J, Sheng M. Identification and characterization of neuronal mitogen-activated protein kinase substrates using a specific phosphomotif antibody. Mol Cell Proteomics. 2009 Apr; 8(4):681-95. PMID: 19054758; PMCID: PMC2667352.
    View in: PubMed, PubMed Central
  113. Yaffe MB. How to "cell" a genomic or proteomic screen. Sci Signal. 2008 Nov 25; 1(47):eg9. PMID: 19036710.
    View in: PubMed
  114. Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells. Mol Biosyst. 2009 Jan; 5(1):59-67. PMID: 19081932; PMCID: PMC2701618.
    View in: PubMed, PubMed Central
  115. Yaffe MB. Signaling networks and mathematics. Sci Signal. 2008 Oct 28; 1(43):eg7. PMID: 18957689.
    View in: PubMed
  116. Janes KA, Reinhardt HC, Yaffe MB. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell. 2008 Oct 17; 135(2):343-54. PMID: 18957207; PMCID: PMC2635014.
    View in: PubMed, PubMed Central
  117. Yi C, Wilker EW, Yaffe MB, Stemmer-Rachamimov A, Kissil JL. Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res. 2008 Oct 01; 68(19):7932-7. PMID: 18829550; PMCID: PMC2707059.
    View in: PubMed, PubMed Central
  118. Dahele M, Hwang D, Peressotti C, Sun L, Kusano M, Okhai S, Darling G, Yaffe M, Caldwell C, Mah K, Hornby J, Ehrlich L, Raphael S, Tsao M, Behzadi A, Weigensberg C, Ung YC. Developing a methodology for three-dimensional correlation of PET-CT images and whole-mount histopathology in non-small-cell lung cancer. Curr Oncol. 2008 Oct; 15(5):62-9. PMID: 19008992; PMCID: PMC2582510.
    View in: PubMed, PubMed Central
  119. Miller ML, Jensen LJ, Diella F, Jørgensen C, Tinti M, Li L, Hsiung M, Parker SA, Bordeaux J, Sicheritz-Ponten T, Olhovsky M, Pasculescu A, Alexander J, Knapp S, Blom N, Bork P, Li S, Cesareni G, Pawson T, Turk BE, Yaffe MB, Brunak S, Linding R. Linear motif atlas for phosphorylation-dependent signaling. Sci Signal. 2008 Sep 02; 1(35):ra2. PMID: 18765831.
    View in: PubMed
  120. Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 2008 Aug 19; 6(8):e203. PMID: 18715118; PMCID: PMC2517623.
    View in: PubMed, PubMed Central
  121. Tian W, Li XJ, Stull ND, Ming W, Suh CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC. Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome. Blood. 2008 Nov 01; 112(9):3867-77. PMID: 18711001; PMCID: PMC2572805.
    View in: PubMed, PubMed Central
  122. Macurek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, Clouin C, Taylor SS, Yaffe MB, Medema RH. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature. 2008 Sep 04; 455(7209):119-23. PMID: 18615013.
    View in: PubMed
  123. Varelas X, Sakuma R, Samavarchi-Tehrani P, Peerani R, Rao BM, Dembowy J, Yaffe MB, Zandstra PW, Wrana JL. TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol. 2008 Jul; 10(7):837-48. PMID: 18568018.
    View in: PubMed
  124. Bissonnette SA, Glazier CM, Stewart MQ, Brown GE, Ellson CD, Yaffe MB. Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase. J Biol Chem. 2008 Jan 25; 283(4):2108-19. PMID: 18029359; PMCID: PMC2755574.
    View in: PubMed, PubMed Central
  125. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007 Nov 30; 131(5):901-14. PMID: 18001825; PMCID: PMC2149842.
    View in: PubMed, PubMed Central
  126. Linding R, Jensen LJ, Pasculescu A, Olhovsky M, Colwill K, Bork P, Yaffe MB, Pawson T. NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res. 2008 Jan; 36(Database issue):D695-9. PMID: 17981841; PMCID: PMC2238868.
    View in: PubMed, PubMed Central
  127. Snead JL, Sullivan M, Lowery DM, Cohen MS, Zhang C, Randle DH, Taunton J, Yaffe MB, Morgan DO, Shokat KM. A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol. 2007 Nov; 14(11):1261-72. PMID: 18022565; PMCID: PMC2215327.
    View in: PubMed, PubMed Central
  128. Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic. 2007 Oct; 8(10):1365-74. PMID: 17645435.
    View in: PubMed
  129. Tian Y, Kolb R, Hong JH, Carroll J, Li D, You J, Bronson R, Yaffe MB, Zhou J, Benjamin T. TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol. 2007 Sep; 27(18):6383-95. PMID: 17636028; PMCID: PMC2099608.
    View in: PubMed, PubMed Central
  130. Linding R, Jensen LJ, Ostheimer GJ, van Vugt MA, Jørgensen C, Miron IM, Diella F, Colwill K, Taylor L, Elder K, Metalnikov P, Nguyen V, Pasculescu A, Jin J, Park JG, Samson LD, Woodgett JR, Russell RB, Bork P, Yaffe MB, Pawson T. Systematic discovery of in vivo phosphorylation networks. Cell. 2007 Jun 29; 129(7):1415-26. PMID: 17570479; PMCID: PMC2692296.
    View in: PubMed, PubMed Central
  131. Lowery DM, Clauser KR, Hjerrild M, Lim D, Alexander J, Kishi K, Ong SE, Gammeltoft S, Carr SA, Yaffe MB. Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J. 2007 May 02; 26(9):2262-73. PMID: 17446864; PMCID: PMC1864981.
    View in: PubMed, PubMed Central
  132. Manke IA, Yaffe MB. Screening kinase phosphorylation motifs using Peptide libraries. CSH Protoc. 2007 Apr 01; 2007:pdb.prot4640. PMID: 21357059.
    View in: PubMed
  133. Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 2007 Mar 15; 446(7133):329-32. PMID: 17361185.
    View in: PubMed
  134. Reinhardt HC, Aslanian AS, Lees JA, Yaffe MB. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell. 2007 Feb; 11(2):175-89. PMID: 17292828; PMCID: PMC2742175.
    View in: PubMed, PubMed Central
  135. Yaffe MB, White FM. Signaling netwErks get the global treatment. Genome Biol. 2007; 8(1):202. PMID: 17274840; PMCID: PMC1839117.
    View in: PubMed, PubMed Central
  136. Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):820-8. PMID: 17057752.
    View in: PubMed
  137. Nishikawa K, Watanabe M, Kita E, Igai K, Omata K, Yaffe MB, Natori Y. A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin. FASEB J. 2006 Dec; 20(14):2597-9. PMID: 17065223.
    View in: PubMed
  138. Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006 Aug 01; 66(15):7473-81. PMID: 16885344.
    View in: PubMed
  139. Suh CI, Stull ND, Li XJ, Tian W, Price MO, Grinstein S, Yaffe MB, Atkinson S, Dinauer MC. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med. 2006 Aug 07; 203(8):1915-25. PMID: 16880255; PMCID: PMC2118377.
    View in: PubMed, PubMed Central
  140. Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev. 2006 Jul 01; 20(13):1715-20. PMID: 16818603; PMCID: PMC1522067.
    View in: PubMed, PubMed Central
  141. Yaffe MB. "Bits" and pieces. Sci STKE. 2006 Jun 20; 2006(340):pe28. PMID: 16788164.
    View in: PubMed
  142. Yoshida S, Kono K, Lowery DM, Bartolini S, Yaffe MB, Ohya Y, Pellman D. Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science. 2006 Jul 07; 313(5783):108-11. PMID: 16763112.
    View in: PubMed
  143. Gardino AK, Smerdon SJ, Yaffe MB. Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol. 2006 Jun; 16(3):173-82. PMID: 16678437.
    View in: PubMed
  144. Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38. PMID: 16417406; PMCID: PMC1334198.
    View in: PubMed, PubMed Central
  145. Hong JH, Yaffe MB. TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle. 2006 Jan; 5(2):176-9. PMID: 16397409.
    View in: PubMed
  146. Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell. 2005 Dec 29; 123(7):1213-26. PMID: 16377563.
    View in: PubMed
  147. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 09; 310(5754):1646-53. PMID: 16339439.
    View in: PubMed
  148. Yaffe MB. X-ray crystallography and structural biology. Crit Care Med. 2005 Dec; 33(12 Suppl):S435-40. PMID: 16340415.
    View in: PubMed
  149. Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell. 2005 Oct 28; 20(2):199-211. PMID: 16246723.
    View in: PubMed
  150. Mah AS, Elia AE, Devgan G, Ptacek J, Schutkowski M, Snyder M, Yaffe MB, Deshaies RJ. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem. 2005 Oct 21; 6:22. PMID: 16242037; PMCID: PMC1277818.
    View in: PubMed, PubMed Central
  151. Russ WP, Lowery DM, Mishra P, Yaffe MB, Ranganathan R. Natural-like function in artificial WW domains. Nature. 2005 Sep 22; 437(7058):579-83. PMID: 16177795.
    View in: PubMed
  152. Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science. 2005 Aug 12; 309(5737):1074-8. PMID: 16099986.
    View in: PubMed
  153. Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ. Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol. 2005 Jun 21; 15(12):1078-89. PMID: 15964272.
    View in: PubMed
  154. Mahoney WM, Hong JH, Yaffe MB, Farrance IK. The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J. 2005 May 15; 388(Pt 1):217-25. PMID: 15628970; PMCID: PMC1186710.
    View in: PubMed, PubMed Central
  155. Wilker EW, Grant RA, Artim SC, Yaffe MB. A structural basis for 14-3-3sigma functional specificity. J Biol Chem. 2005 May 13; 280(19):18891-8. PMID: 15731107.
    View in: PubMed
  156. Lowery DM, Lim D, Yaffe MB. Structure and function of Polo-like kinases. Oncogene. 2005 Jan 10; 24(2):248-59. PMID: 15640840.
    View in: PubMed
  157. Manke IA, Nguyen A, Lim D, Stewart MQ, Elia AE, Yaffe MB. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell. 2005 Jan 07; 17(1):37-48. PMID: 15629715.
    View in: PubMed
  158. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro. J Biol Chem. 2005 Mar 18; 280(11):9780-5. PMID: 15640142.
    View in: PubMed
  159. Joughin BA, Tidor B, Yaffe MB. A computational method for the analysis and prediction of protein:phosphopeptide-binding sites. Protein Sci. 2005 Jan; 14(1):131-9. PMID: 15576564; PMCID: PMC2253325.
    View in: PubMed, PubMed Central
  160. Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem. 2005 Mar 04; 280(9):7519-29. PMID: 15475363; PMCID: PMC2409062.
    View in: PubMed, PubMed Central
  161. Yaffe MB. Novel at the library. Nat Methods. 2004 Oct; 1(1):13-4. PMID: 15782146.
    View in: PubMed
  162. Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell. 2004 Oct; 7(4):571-83. PMID: 15469845.
    View in: PubMed
  163. Wilker E, Yaffe MB. 14-3-3 Proteins--a focus on cancer and human disease. J Mol Cell Cardiol. 2004 Sep; 37(3):633-42. PMID: 15350836.
    View in: PubMed
  164. Nguyen A, Rothman DM, Stehn J, Imperiali B, Yaffe MB. Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function. Nat Biotechnol. 2004 Aug; 22(8):993-1000. PMID: 15273693.
    View in: PubMed
  165. Diorio C, Pollak M, Byrne C, Mâsse B, Côté G, Hébert-Croteau N, Yaffe M, Bérubé S, Morin C, Brisson J. Insulin-like growth factor-I (IGF-I), IGF-binding protein-3 (IGFBP-3), and mammographic breast density. J Clin Oncol. 2004 Jul 15; 22(14_suppl):9501. PMID: 28016801.
    View in: PubMed
  166. Dalal SN, Yaffe MB, DeCaprio JA. 14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle. 2004 May; 3(5):672-7. PMID: 15107609.
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  167. Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004 Jun; 11(6):512-8. PMID: 15133502.
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  168. Brown GE, Stewart MQ, Bissonnette SA, Elia AE, Wilker E, Yaffe MB. Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem. 2004 Jun 25; 279(26):27059-68. PMID: 15102856.
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  169. Yaffe MB. Master of all things phosphorylated. Biochem J. 2004 Apr 15; 379(Pt 2):e1-2. PMID: 15061704; PMCID: PMC1224097.
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  170. Park KS, Whitsett JA, Di Palma T, Hong JH, Yaffe MB, Zannini M. TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem. 2004 Apr 23; 279(17):17384-90. PMID: 14970209.
    View in: PubMed
  171. Lowery DM, Mohammad DH, Elia AE, Yaffe MB. The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function. Cell Cycle. 2004 Feb; 3(2):128-31. PMID: 14712072.
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  172. Obenauer JC, Yaffe MB. Computational prediction of protein-protein interactions. Methods Mol Biol. 2004; 261:445-68. PMID: 15064475.
    View in: PubMed
  173. Yaffe MB, Smerdon SJ. The use of in vitro peptide-library screens in the analysis of phosphoserine/threonine-binding domain structure and function. Annu Rev Biophys Biomol Struct. 2004; 33:225-44. PMID: 15139812.
    View in: PubMed
  174. Yaffe MB. Study of substrate specificity of MAPKs using oriented peptide libraries. Methods Mol Biol. 2004; 250:237-50. PMID: 14755092.
    View in: PubMed
  175. Endy D, Yaffe MB. Signal transduction: molecular monogamy. Nature. 2003 Dec 11; 426(6967):614-5. PMID: 14668845.
    View in: PubMed
  176. Manke IA, Lowery DM, Nguyen A, Yaffe MB. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science. 2003 Oct 24; 302(5645):636-9. PMID: 14576432.
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  177. Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 2003 Oct 03; 115(1):83-95. PMID: 14532005.
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  178. Kugathasan S, Judd RH, Hoffmann RG, Heikenen J, Telega G, Khan F, Weisdorf-Schindele S, San Pablo W, Perrault J, Park R, Yaffe M, Brown C, Rivera-Bennett MT, Halabi I, Martinez A, Blank E, Werlin SL, Rudolph CD, Binion DG. Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population-based study. J Pediatr. 2003 Oct; 143(4):525-31. PMID: 14571234.
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  179. Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell. 2003 Oct; 12(4):841-9. PMID: 14580336.
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  180. Vázquez ME, Nitz M, Stehn J, Yaffe MB, Imperiali B. Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations. J Am Chem Soc. 2003 Aug 27; 125(34):10150-1. PMID: 12926919.
    View in: PubMed
  181. Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR. Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003 Aug; 23(15):5376-87. PMID: 12861023; PMCID: PMC165733.
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  182. Obenauer JC, Cantley LC, Yaffe MB. Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 2003 Jul 01; 31(13):3635-41. PMID: 12824383; PMCID: PMC168990.
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  183. Stone J, Gunasekara A, Martin LJ, Yaffe M, Minkin S, Boyd NF. The detection of change in mammographic density. Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):625-30. PMID: 12869401.
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  184. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73. PMID: 12832460.
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  185. Manke IA, Yaffe MB. Chk'n out in mitosis. Cell Cycle. 2003 May-Jun; 2(3):236-7. PMID: 12775938.
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  186. Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science. 2003 Feb 21; 299(5610):1228-31. PMID: 12595692.
    View in: PubMed
  187. Nguyen A, Yaffe MB. Proteomics and systems biology approaches to signal transduction in sepsis. Crit Care Med. 2003 Jan; 31(1 Suppl):S1-6. PMID: 12544970.
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  188. Yaffe MB. Studying the optimal peptide substrate motifs of protein kinase C using oriented peptide libraries. Methods Mol Biol. 2003; 233:273-85. PMID: 12840514.
    View in: PubMed
  189. Brown GE, Stewart MQ, Liu H, Ha VL, Yaffe MB. A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell. 2003 Jan; 11(1):35-47. PMID: 12535519.
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  190. Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S. The association of breast mitogens with mammographic densities. Br J Cancer. 2002 Oct 07; 87(8):876-82. PMID: 12373602; PMCID: PMC2376176.
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  191. Yaffe MB. The p47phox PX domain: two heads are better than one! Structure. 2002 Oct; 10(10):1288-90. PMID: 12377114.
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  192. Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ. Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell. 2002 May; 9(5):1045-54. PMID: 12049740.
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  193. Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002 May 17; 277(20):18029-36. PMID: 11886850.
    View in: PubMed
  194. Yaffe MB. Phosphotyrosine-binding domains in signal transduction. Nat Rev Mol Cell Biol. 2002 Mar; 3(3):177-86. PMID: 11994738.
    View in: PubMed
  195. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002 Mar 04; 156(5):817-28. PMID: 11864996.
    View in: PubMed
  196. Yaffe MB. How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett. 2002 Feb 20; 513(1):53-7. PMID: 11911880.
    View in: PubMed
  197. Yaffe MB. MAGUK SH3 domains--swapped and stranded by their kinases? Structure. 2002 Jan; 10(1):3-5. PMID: 11796103.
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  198. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 01; 20(21):5840-52. PMID: 11689425; PMCID: PMC125701.
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  199. He J, Lau AG, Yaffe MB, Hall RA. Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. J Biol Chem. 2001 Nov 09; 276(45):41559-65. PMID: 11533036.
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  200. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol. 2001 Jul; 3(7):675-8. PMID: 11433300.
    View in: PubMed
  201. Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol. 2001 Apr; 19(4):348-53. PMID: 11283593.
    View in: PubMed
  202. Yaffe MB, Elia AE. Phosphoserine/threonine-binding domains. Curr Opin Cell Biol. 2001 Apr; 13(2):131-8. PMID: 11248545.
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  203. Yaffe MB, Smerdon SJ. PhosphoSerine/threonine binding domains: you can't pSERious? Structure. 2001 Mar 07; 9(3):R33-8. PMID: 11286893.
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  204. Johnson BA, Yaffe M, Blackwell TK. Molecular Analysis of TTP, a Key Regulator of TNF Activity. ScientificWorldJournal. 2001; 1:38. PMID: 30147482.
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  205. Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000 Dec 15; 19(24):6778-91. PMID: 11118213; PMCID: PMC305881.
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  206. Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17; 275(46):36108-15. PMID: 10945990.
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  207. Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell. 2000 Nov; 6(5):1169-82. PMID: 11106755.
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  208. Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Mol Cell. 2000 Oct; 6(4):969-74. PMID: 11090635.
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  209. Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. J Biol Chem. 2000 Sep 08; 275(36):28167-72. PMID: 10862767.
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  210. Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell. 2000 Jul; 6(1):41-51. PMID: 10949026.
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  211. Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem. 2000 May 26; 275(21):16030-6. PMID: 10748127.
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  212. Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 07; 275(14):10359-69. PMID: 10744724.
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  213. Obata T, Brown GE, Yaffe MB. MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit Care Med. 2000 Apr; 28(4 Suppl):N67-77. PMID: 10807318.
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  214. Yaffe MB, Fink MP. Cellular signaling in critical care--putting the pieces together. Crit Care Med. 2000 Apr; 28(4 Suppl):N1-2. PMID: 10807311.
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  215. Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21; 275(3):2219-30. PMID: 10636929.
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  216. Yaffe MB, Cantley LC. Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods Enzymol. 2000; 328:157-70. PMID: 11075345.
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  217. Durocher D, Smerdon SJ, Yaffe MB, Jackson SP. The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harb Symp Quant Biol. 2000; 65:423-31. PMID: 12760058.
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  218. Yaffe MB, Cantley LC. Signal transduction. Grabbing phosphoproteins. Nature. 1999 Nov 04; 402(6757):30-1. PMID: 10573413.
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  219. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999 Oct; 4(4):555-61. PMID: 10549287.
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  220. Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24; 285(5436):2129-33. PMID: 10497131.
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  221. Yaffe MB, Xu J, Burke PA, Forse RA, Brown GE. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. Surgery. 1999 Aug; 126(2):248-54. PMID: 10455891.
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  222. Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell. 1999 Aug; 4(2):153-66. PMID: 10488331.
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  223. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. PMID: 9774973.
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  224. Boyd NF, Martin L, Lockwood G, Greenberg C, Yaffe M, Tritchler D. Diet and breast cancer. Nutrition. 1998 Sep; 14(9):722-4. PMID: 9760600.
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  225. Samuels TH, Liu FF, Yaffe M, Haider M. Gestational breast cancer. Can Assoc Radiol J. 1998 Jun; 49(3):172-80. PMID: 9640283.
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  226. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 1997 Dec 26; 91(7):961-71. PMID: 9428519.
    View in: PubMed
  227. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60. PMID: 9395400.
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  228. Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J Biol Chem. 1997 Sep 19; 272(38):23696-702. PMID: 9295312.
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  229. Boyd NF, Greenberg C, Lockwood G, Little L, Martin L, Byng J, Yaffe M, Tritchler D. Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst. 1997 Apr 02; 89(7):488-96. PMID: 9086005.
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  230. Burke PA, Luo M, Zhu J, Yaffe MB, Forse RA. Injury induces rapid changes in hepatocyte nuclear factor-1: DNA binding. Surgery. 1996 Aug; 120(2):374-80; discussion 380-1. PMID: 8751607.
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  231. Boyd NF, Connelly P, Byng J, Yaffe M, Draper H, Little L, Jones D, Martin LJ, Lockwood G, Tritchler D. Plasma lipids, lipoproteins, and mammographic densities. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov; 4(7):727-33. PMID: 8672989.
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  232. Burke PA, Drotar M, Luo M, Yaffe M, Forse RA. Rapid modulation of liver-specific transcription factors after injury. Surgery. 1994 Aug; 116(2):285-92; discussion 292-3. PMID: 8047996.
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  233. Sternlicht H, Farr GW, Sternlicht ML, Driscoll JK, Willison K, Yaffe MB. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9422-6. PMID: 8105476; PMCID: PMC47580.
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  234. Eckert RL, Yaffe MB, Crish JF, Murthy S, Rorke EA, Welter JF. Involucrin--structure and role in envelope assembly. J Invest Dermatol. 1993 May; 100(5):613-7. PMID: 8098344.
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  235. Yaffe MB, Murthy S, Eckert RL. Evidence that involucrin is a covalently linked constituent of highly purified cultured keratinocyte cornified envelopes. J Invest Dermatol. 1993 Jan; 100(1):3-9. PMID: 8423390.
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  236. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature. 1992 Jul 16; 358(6383):245-8. PMID: 1630491.
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  237. Hoffman P, Yaffe MB, Hoffman BL, Yei S, Wold WS, Carlin C. Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor. Evidence for intermolecular disulfide bonding and plasma membrane localization. J Biol Chem. 1992 Jul 05; 267(19):13480-7. PMID: 1377684.
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  238. Yaffe MB, Beegen H, Eckert RL. Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope. J Biol Chem. 1992 Jun 15; 267(17):12233-8. PMID: 1601889.
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  239. Farr GW, Yaffe MB, Sternlicht H. Alpha-tubulin influences nucleotide binding to beta-tubulin: an assay using picomoles of unpurified protein. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5041-5. PMID: 2367522; PMCID: PMC54257.
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  240. Yaffe MB, Levison BS, Szasz J, Sternlicht H. Expression of a human alpha-tubulin: properties of the isolated subunit. Biochemistry. 1988 Mar 22; 27(6):1869-80. PMID: 2897863.
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  241. Sternlicht H, Yaffe MB, Farr GW. A model of the nucleotide-binding site in tubulin. FEBS Lett. 1987 Apr 20; 214(2):226-35. PMID: 3106086.
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  242. Szasz J, Yaffe MB, Elzinga M, Blank GS, Sternlicht H. Microtubule assembly is dependent on a cluster of basic residues in alpha-tubulin. Biochemistry. 1986 Aug 12; 25(16):4572-82. PMID: 3768299.
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  243. Blank GS, Yaffe MB, Szasz J, George E, Rosenberry TL, Sternlicht H. The role of Lys 394 in microtubule assembly. Ann N Y Acad Sci. 1986; 466:467-81. PMID: 3089112.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.