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Last Name
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profileMichael Bruce Yaffe, M.D., PH.D.

TitleInstructor in Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentSurgery
AddressHarvard Medical School
Center for Cancer Research E18-580
77 Massachusetts Ave
Cambridge MA 02139
Phone617/452-2103
Fax617/452-4978
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Characterizing Cell-Specific Radiation Sensitization Induced by HDAC Inhibition
Summer, 05/29/12 - 08/17/12

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
R35ES028374     (YAFFE, MICHAEL B)Sep 1, 2017 - Jul 31, 2025
NIH/NIEHS
Protein Kinase Signaling in the Genotoxic Stress Response
Role: Principal Investigator
R01CA185137     (CHAREST, ALAIN)Sep 1, 2014 - Aug 31, 2018
NIH/NCI
(PQB5)Molecular Wiring and Therapeutic Targeting of EGFR and PDGFR Signaling Netw
Role: Co-Principal Investigator
R01GM104047     (TURK, BENJAMIN E)Sep 10, 2013 - May 31, 2018
NIH/NIGMS
Modeling human phosphorylation networks through kinome-wide profiling
Role: Co-Principal Investigator
R21ES020466     (YAFFE, MICHAEL B)Jul 1, 2012 - Jun 30, 2014
NIH/NIEHS
Phospho-Binding Ligands and Substrates of BRCA1
Role: Principal Investigator
R21NS063917     (YAFFE, MICHAEL B)Jun 15, 2008 - May 31, 2010
NIH/NINDS
High-content screening for modifiers of the DNA damage response
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Barrett CD, Moore HB, Banerjee A, Silliman CC, Moore EE, Yaffe MB. Human Neutrophil Elastase Mediates Fibrinolysis Shutdown Through Competitive Degradation of Plasminogen and Generation of Angiostatin. J Trauma Acute Care Surg. 2017 Aug 23. PMID: 28837538.
    View in: PubMed
  2. Yaffe MB. Highlight: Understanding radiation sialadenitis. Sci Signal. 2017 Jun 06; 10(482). PMID: 28588084.
    View in: PubMed
  3. Yaffe M. Highlight: A new way to block the development of asthma from dust mites. Sci Signal. 2017 Apr 18; 10(475). PMID: 28420752.
    View in: PubMed
  4. Yaffe MB, VanHook AM. Science Signaling Podcast for 14 March 2017: The Cancer Moonshot. Sci Signal. 2017 Mar 14; 10(470). PMID: 28292953.
    View in: PubMed
  5. Xiao H, Qi R, Li T, Awuah SG, Zheng Y, Wei W, Kang X, Song H, Wang Y, Yu Y, Bird MA, Jing X, Yaffe MB, Birrer MJ, Ghoroghchian PP. Maximizing Synergistic Activity When Combining RNAi and Platinum-Based Anticancer Agents. J Am Chem Soc. 2017 Mar 01; 139(8):3033-3044. PMID: 28166401.
    View in: PubMed
  6. Lee MJ, Yaffe MB. Protein Regulation in Signal Transduction. Cold Spring Harb Perspect Biol. 2016 Jun 01; 8(6). PMID: 27252361.
    View in: PubMed
  7. Lam FC, Yaffe MB. Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma. Cancer Cell. 2016 Apr 11; 29(4):435-436. PMID: 27070697.
    View in: PubMed
  8. Yaffe MB, Gough NR. Leveraging signaling research to understand and treat disease. Sci Signal. 2016 Mar 29; 9(421):eg4. PMID: 27025875.
    View in: PubMed
  9. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Dec 14; 28(6):831. PMID: 28843280.
    View in: PubMed
  10. Cannell IG, Merrick KA, Morandell S, Zhu CQ, Braun CJ, Grant RA, Cameron ER, Tsao MS, Hemann MT, Yaffe MB. A Pleiotropic RNA-Binding Protein Controls Distinct Cell Cycle Checkpoints to Drive Resistance of p53-Defective Tumors to Chemotherapy. Cancer Cell. 2015 Nov 09; 28(5):623-637. PMID: 26602816; PMCID: PMC4830093 [Available on 11/09/16].
    View in: PubMed, PubMed Central
  11. Qian WJ, Park JE, Grant R, Lai CC, Kelley JA, Yaffe MB, Lee KS, Burke TR. Neighbor-directed histidine N (t)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles. Biopolymers. 2015 Nov; 104(6):663-73. PMID: 26152807; PMCID: PMC4865893 [Available on 11/01/16].
    View in: PubMed, PubMed Central
  12. Hsu AT, Barrett CD, DeBusk GM, Ellson CD, Gautam S, Talmor DS, Gallagher DC, Yaffe MB. Kinetics and Role of Plasma Matrix Metalloproteinase-9 Expression in Acute Lung Injury and the Acute Respiratory Distress Syndrome. Shock. 2015 Aug; 44(2):128-36. PMID: 26009816; PMCID: PMC4830084.
    View in: PubMed, PubMed Central
  13. Dreaden EC, Kong YW, Morton SW, Correa S, Choi KY, Shopsowitz KE, Renggli K, Drapkin R, Yaffe MB, Hammond PT. Tumor-Targeted Synergistic Blockade of MAPK and PI3K from a Layer-by-Layer Nanoparticle. Clin Cancer Res. 2015 Oct 01; 21(19):4410-9. PMID: 26034127; PMCID: PMC4624301 [Available on 10/01/16].
    View in: PubMed, PubMed Central
  14. Rameseder J, Krismer K, Dayma Y, Ehrenberger T, Hwang MK, Airoldi EM, Floyd SR, Yaffe MB. A Multivariate Computational Method to Analyze High-Content RNAi Screening Data. J Biomol Screen. 2015 Sep; 20(8):985-97. PMID: 25918037.
    View in: PubMed
  15. Zhu EF, Gai SA, Opel CF, Kwan BH, Surana R, Mihm MC, Kauke MJ, Moynihan KD, Angelini A, Williams RT, Stephan MT, Kim JS, Yaffe MB, Irvine DJ, Weiner LM, Dranoff G, Wittrup KD. Synergistic innate and adaptive immune response to combination immunotherapy with anti-tumor antigen antibodies and extended serum half-life IL-2. Cancer Cell. 2015 Apr 13; 27(4):489-501. PMID: 25873172; PMCID: PMC4398916.
    View in: PubMed, PubMed Central
  16. Naegle K, Gough NR, Yaffe MB. Criteria for biological reproducibility: what does "n" mean? Sci Signal. 2015 Apr 07; 8(371):fs7. PMID: 25852186.
    View in: PubMed
  17. Yaffe MB. Reproducibility in science. Sci Signal. 2015 Apr 07; 8(371):eg5. PMID: 25852185.
    View in: PubMed
  18. Bryson BD, Del Rosario AM, Gootenberg JS, Yaffe MB, White FM. Engineered bromodomains to explore the acetylproteome. Proteomics. 2015 May; 15(9):1470-5. PMID: 25641834; PMCID: PMC4535431.
    View in: PubMed, PubMed Central
  19. Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods Mol Biol. 2015; 1278:57-75. PMID: 25859943; PMCID: PMC4435844.
    View in: PubMed, PubMed Central
  20. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Mol Cell. 2015 Jan 08; 57(1):95-107. PMID: 25482511; PMCID: PMC4289430.
    View in: PubMed, PubMed Central
  21. Gates JD, Arabian S, Biddinger P, Blansfield J, Burke P, Chung S, Fischer J, Friedman F, Gervasini A, Goralnick E, Gupta A, Larentzakis A, McMahon M, Mella J, Michaud Y, Mooney D, Rabinovici R, Sweet D, Ulrich A, Velmahos G, Weber C, Yaffe MB. The initial response to the Boston marathon bombing: lessons learned to prepare for the next disaster. Ann Surg. 2014 Dec; 260(6):960-6. PMID: 25386862.
    View in: PubMed
  22. Qian WJ, Park JE, Lim D, Lai CC, Kelley JA, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells. Biopolymers. 2014 Nov; 102(6):444-55. PMID: 25283071; PMCID: PMC4895914.
    View in: PubMed, PubMed Central
  23. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2014 Sep 18; 21(9):1254. PMID: 25368881; PMCID: PMC4379504.
    View in: PubMed, PubMed Central
  24. Peterson LB, Yaffe MB, Imperiali B. Selective mitogen activated protein kinase activity sensors through the application of directionally programmable D domain motifs. Biochemistry. 2014 Sep 16; 53(36):5771-8. PMID: 25153342; PMCID: PMC4165445.
    View in: PubMed, PubMed Central
  25. Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM. Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition. Cell. 2014 Aug 28; 158(5):1094-109. PMID: 25171410; PMCID: PMC4250222.
    View in: PubMed, PubMed Central
  26. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11; 26(2):222-34. PMID: 25117710; PMCID: PMC4169234.
    View in: PubMed, PubMed Central
  27. Liu B, Yang K, Yaffe M, Chen J. TH-A-18A-01: Innovation in Clinical Breast Imaging. Med Phys. 2014 Jun; 41(6):532-533. PMID: 28037992.
    View in: PubMed
  28. Morton SW, Lee MJ, Deng ZJ, Dreaden EC, Siouve E, Shopsowitz KE, Shah NJ, Yaffe MB, Hammond PT. A nanoparticle-based combination chemotherapy delivery system for enhanced tumor killing by dynamic rewiring of signaling pathways. Sci Signal. 2014 May 13; 7(325):ra44. PMID: 24825919; PMCID: PMC4138219.
    View in: PubMed, PubMed Central
  29. Byun MR, Hwang JH, Kim AR, Kim KM, Hwang ES, Yaffe MB, Hong JH. Canonical Wnt signalling activates TAZ through PP1A during osteogenic differentiation. Cell Death Differ. 2014 Jun; 21(6):854-63. PMID: 24510127; PMCID: PMC4013522.
    View in: PubMed, PubMed Central
  30. Sudol M, Yaffe MB. Death of a Titan. Sci Signal. 2013 Dec 17; 6(306):eg6. PMID: 24345678.
    View in: PubMed
  31. Morandell S, Reinhardt HC, Cannell IG, Kim JS, Ruf DM, Mitra T, Couvillon AD, Jacks T, Yaffe MB. A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep. 2013 Nov 27; 5(4):868-77. PMID: 24239348; PMCID: PMC3962842.
    View in: PubMed, PubMed Central
  32. Lim D, Gold DA, Julien L, Rosowski EE, Niedelman W, Yaffe MB, Saeij JP. Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence. J Biol Chem. 2013 Nov 29; 288(48):34968-80. PMID: 24129568; PMCID: PMC3843107.
    View in: PubMed, PubMed Central
  33. Qian WJ, Park JE, Lim D, Park SY, Lee KW, Yaffe MB, Lee KS, Burke TR. Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs. Chem Biol. 2013 Oct 24; 20(10):1255-64. PMID: 24120332; PMCID: PMC3859306.
    View in: PubMed, PubMed Central
  34. Reinhardt HC, Yaffe MB. Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol. 2013 Sep; 14(9):563-80. PMID: 23969844.
    View in: PubMed
  35. Kang SA, Pacold ME, Cervantes CL, Lim D, Lou HJ, Ottina K, Gray NS, Turk BE, Yaffe MB, Sabatini DM. mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science. 2013 Jul 26; 341(6144):1236566. PMID: 23888043; PMCID: PMC3771538.
    View in: PubMed, PubMed Central
  36. Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB. The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature. 2013 Jun 13; 498(7453):246-50. PMID: 23728299; PMCID: PMC3683358.
    View in: PubMed, PubMed Central
  37. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806; PMCID: PMC3759823.
    View in: PubMed, PubMed Central
  38. Yaffe M. Newsmaker interview: Michael Yaffe. Boston bombing victims aided by biologist-surgeon. Interview with Trisha Gura. Science. 2013 May 10; 340(6133):671. PMID: 23661732.
    View in: PubMed
  39. Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR, Winey M, Smerdon SJ, Yaffe MB, Amon A. Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes. Science. 2013 May 17; 340(6134):871-5. PMID: 23579499; PMCID: PMC3884217.
    View in: PubMed, PubMed Central
  40. Yaffe MB. The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment. Sci Signal. 2013 Apr 02; 6(269):pe13. PMID: 23550209.
    View in: PubMed
  41. Murugan RN, Park JE, Lim D, Ahn M, Cheong C, Kwon T, Nam KY, Choi SH, Kim BY, Yoon DY, Yaffe MB, Yu DY, Lee KS, Bang JK. Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1. Bioorg Med Chem. 2013 May 01; 21(9):2623-34. PMID: 23498919.
    View in: PubMed
  42. Weingeist DM, Ge J, Wood DK, Mutamba JT, Huang Q, Rowland EA, Yaffe MB, Floyd S, Engelward BP. Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. Cell Cycle. 2013 Mar 15; 12(6):907-15. PMID: 23422001; PMCID: PMC3637349.
    View in: PubMed, PubMed Central
  43. Yaffe MB, Gough NR. 2012: Signaling breakthroughs of the year. Sci Signal. 2013 Jan 01; 6(256):eg1. PMID: 23281367.
    View in: PubMed
  44. Naegle KM, White FM, Lauffenburger DA, Yaffe MB. Robust co-regulation of tyrosine phosphorylation sites on proteins reveals novel protein interactions. Mol Biosyst. 2012 Oct; 8(10):2771-82. PMID: 22851037; PMCID: PMC3501258.
    View in: PubMed, PubMed Central
  45. Noonan EM, Shah D, Yaffe MB, Lauffenburger DA, Samson LD. O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation. Integr Biol (Camb). 2012 Oct; 4(10):1237-55. PMID: 22892544; PMCID: PMC3574819.
    View in: PubMed, PubMed Central
  46. Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19; 367(1602):2574-83. PMID: 22889908; PMCID: PMC3415838.
    View in: PubMed, PubMed Central
  47. Höpker K, Hagmann H, Khurshid S, Chen S, Hasskamp P, Seeger-Nukpezah T, Schilberg K, Heukamp L, Lamkemeyer T, Sos ML, Thomas RK, Lowery D, Roels F, Fischer M, Liebau MC, Resch U, Kisner T, Röther F, Bartram MP, Müller RU, Fabretti F, Kurschat P, Schumacher B, Gaestel M, Medema RH, Yaffe MB, Schermer B, Reinhardt HC, Benzing T. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis. EMBO J. 2012 Oct 17; 31(20):3961-75. PMID: 22909821; PMCID: PMC3474921.
    View in: PubMed, PubMed Central
  48. Singh N, Basnet H, Wiltshire TD, Mohammad DH, Thompson JR, Héroux A, Botuyan MV, Yaffe MB, Couch FJ, Rosenfeld MG, Mer G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14381-6. PMID: 22908299; PMCID: PMC3437875.
    View in: PubMed, PubMed Central
  49. Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JP. The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog. 2012; 8(6):e1002784. PMID: 22761577; PMCID: PMC3386190.
    View in: PubMed, PubMed Central
  50. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94. PMID: 22579283; PMCID: PMC3501264.
    View in: PubMed, PubMed Central
  51. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Peptoid-Peptide hybrid ligands targeting the polo box domain of polo-like kinase 1. Chembiochem. 2012 Jun 18; 13(9):1291-6. PMID: 22570300; PMCID: PMC4536914.
    View in: PubMed, PubMed Central
  52. Kholodenko B, Yaffe MB, Kolch W. Computational approaches for analyzing information flow in biological networks. Sci Signal. 2012 Apr 17; 5(220):re1. PMID: 22510471.
    View in: PubMed
  53. Liu F, Park JE, Qian WJ, Lim D, Scharow A, Berg T, Yaffe MB, Lee KS, Burke TR. Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol. 2012 May 18; 7(5):805-10. PMID: 22292814; PMCID: PMC3355227.
    View in: PubMed, PubMed Central
  54. Mohammad DH, Yaffe MB. Fixin' to divide. Mol Cell. 2012 Feb 10; 45(3):273-5. PMID: 22325348; PMCID: PMC3501254.
    View in: PubMed, PubMed Central
  55. Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB. Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol. 2012 Jan 31; 8:568. PMID: 22294094; PMCID: PMC3296916.
    View in: PubMed, PubMed Central
  56. Lee CH, Ou WB, Mariño-Enriquez A, Zhu M, Mayeda M, Wang Y, Guo X, Brunner AL, Amant F, French CA, West RB, McAlpine JN, Gilks CB, Yaffe MB, Prentice LM, McPherson A, Jones SJ, Marra MA, Shah SP, van de Rijn M, Huntsman DG, Dal Cin P, Debiec-Rychter M, Nucci MR, Fletcher JA. 14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):929-34. PMID: 22223660; PMCID: PMC3271913.
    View in: PubMed, PubMed Central
  57. Morandell S, Yaffe MB. Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy. Prog Mol Biol Transl Sci. 2012; 110:289-314. PMID: 22749150.
    View in: PubMed
  58. Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, Yaffe MB, Strano S, Blandino G, Di Agostino S. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle. 2011 Dec 15; 10(24):4330-40. PMID: 22134238.
    View in: PubMed
  59. Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKa2 substrates uncovers a network of proteins involved in mitosis. Mol Cell. 2011 Dec 23; 44(6):878-92. PMID: 22137581; PMCID: PMC3246132.
    View in: PubMed, PubMed Central
  60. Hegemann B, Hutchins JR, Hudecz O, Novatchkova M, Rameseder J, Sykora MM, Liu S, Mazanek M, Lénárt P, Hériché JK, Poser I, Kraut N, Hyman AA, Yaffe MB, Mechtler K, Peters JM. Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal. 2011 Nov 08; 4(198):rs12. PMID: 22067460; PMCID: PMC4206221.
    View in: PubMed, PubMed Central
  61. Gardino AK, Yaffe MB. 14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol. 2011 Sep; 22(7):688-95. PMID: 21945648; PMCID: PMC3507455.
    View in: PubMed, PubMed Central
  62. Grosstessner-Hain K, Hegemann B, Novatchkova M, Rameseder J, Joughin BA, Hudecz O, Roitinger E, Pichler P, Kraut N, Yaffe MB, Peters JM, Mechtler K. Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics. 2011 Nov; 10(11):M111.008540. PMID: 21857030; PMCID: PMC3226402.
    View in: PubMed, PubMed Central
  63. Naegle KM, Welsch RE, Yaffe MB, White FM, Lauffenburger DA. MCAM: multiple clustering analysis methodology for deriving hypotheses and insights from high-throughput proteomic datasets. PLoS Comput Biol. 2011 Jul; 7(7):e1002119. PMID: 21799663; PMCID: PMC3140961.
    View in: PubMed, PubMed Central
  64. Liu F, Park JE, Qian WJ, Lim D, Gräber M, Berg T, Yaffe MB, Lee KS, Burke TR. Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol. 2011 Jul 17; 7(9):595-601. PMID: 21765407; PMCID: PMC3158281.
    View in: PubMed, PubMed Central
  65. Cannell IG, Yaffe MB. Salvaging the septic heart through targeting the interleukin-6/p38 mitogen-activated protein kinase signaling network. Crit Care Med. 2011 Jul; 39(7):1836-7. PMID: 21685754; PMCID: PMC3677698.
    View in: PubMed, PubMed Central
  66. Alexander J, Lim D, Joughin BA, Hegemann B, Hutchins JR, Ehrenberger T, Ivins F, Sessa F, Hudecz O, Nigg EA, Fry AM, Musacchio A, Stukenberg PT, Mechtler K, Peters JM, Smerdon SJ, Yaffe MB. Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal. 2011 Jun 28; 4(179):ra42. PMID: 21712545; PMCID: PMC3939359.
    View in: PubMed, PubMed Central
  67. Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D, Peterson TR, Choi Y, Gray NS, Yaffe MB, Marto JA, Sabatini DM. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science. 2011 Jun 10; 332(6035):1317-22. PMID: 21659604; PMCID: PMC3177140.
    View in: PubMed, PubMed Central
  68. Passaperuma K, Plewes DB, Causer P, Hill KA, Messner SJ, Wong J, Jong RA, Wright F, Yaffe M, Ramsay E, Balasingham S, Verity L, Eisen A, Curpen B, Shumak R, Narod S, Warner E. Long-term results of the Toronto magnetic resonance imaging (MRI) breast surveillance study of women with BRCA1 or BRCA2 mutations. J Clin Oncol. 2011 May 20; 29(15_suppl):542. PMID: 28021507.
    View in: PubMed
  69. Gough NR, Yaffe MB. Focus issue: conquering the data mountain. Sci Signal. 2011 Feb 15; 4(160):eg2. PMID: 21325201.
    View in: PubMed
  70. Reinhardt HC, Cannell IG, Morandell S, Yaffe MB. Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle. 2011 Jan 01; 10(1):23-7. PMID: 21173571; PMCID: PMC3048069.
    View in: PubMed, PubMed Central
  71. Pennell S, Westcott S, Ortiz-Lombardía M, Patel D, Li J, Nott TJ, Mohammed D, Buxton RS, Yaffe MB, Verma C, Smerdon SJ. Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure. 2010 Dec 08; 18(12):1587-95. PMID: 21134638.
    View in: PubMed
  72. Reinhardt HC, Hasskamp P, Schmedding I, Morandell S, van Vugt MA, Wang X, Linding R, Ong SE, Weaver D, Carr SA, Yaffe MB. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell. 2010 Oct 08; 40(1):34-49. PMID: 20932473; PMCID: PMC3030122.
    View in: PubMed, PubMed Central
  73. Yaffe MB. Looking ahead to the past. Sci Signal. 2010 Sep 07; 3(138):eg7. PMID: 20823400.
    View in: PubMed
  74. Sander M, Begley TJ, Desaintes C, Gavin AC, Pelroy R, Pothof J, Shiloh Y, van Gent D, Van Houten B, Yaffe M, Mullenders L. 3rd US-EU workshop: systems level understanding of DNA damage responses. Mutat Res. 2010 Oct 13; 692(1-2):53-60. PMID: 20727903; PMCID: PMC2948618.
    View in: PubMed, PubMed Central
  75. Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics. 2010 Nov; 9(11):2558-70. PMID: 20631208; PMCID: PMC2984232.
    View in: PubMed, PubMed Central
  76. Jiang Y, Puliyappadamba VT, Zhang L, Wu W, Wali A, Yaffe MB, Fontana JA, Rishi AK. A novel mechanism of cell growth regulation by Cell Cycle and Apoptosis Regulatory Protein (CARP)-1. J Mol Signal. 2010 Jul 01; 5:7. PMID: 20594350; PMCID: PMC2904743.
    View in: PubMed, PubMed Central
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  79. Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res. 2010 May 01; 70(9):3843-50. PMID: 20406974; PMCID: PMC2862125.
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  82. Asaoka Y, Kanai F, Ichimura T, Tateishi K, Tanaka Y, Ohta M, Seto M, Tada M, Ijichi H, Ikenoue T, Kawabe T, Isobe T, Yaffe MB, Omata M. Identification of a suppressive mechanism for Hedgehog signaling through a novel interaction of Gli with 14-3-3. J Biol Chem. 2010 Feb 05; 285(6):4185-94. PMID: 19996099; PMCID: PMC2823557.
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  88. Jiang H, Reinhardt HC, Bartkova J, Tommiska J, Blomqvist C, Nevanlinna H, Bartek J, Yaffe MB, Hemann MT. The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 2009 Aug 15; 23(16):1895-909. PMID: 19608766; PMCID: PMC2725944.
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  93. Burkard ME, Maciejowski J, Rodriguez-Bravo V, Repka M, Lowery DM, Clauser KR, Zhang C, Shokat KM, Carr SA, Yaffe MB, Jallepalli PV. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol. 2009 May 05; 7(5):e1000111. PMID: 19468302; PMCID: PMC2680336.
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  94. van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA. Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1. PLoS One. 2009; 4(4):e5282. PMID: 19390576; PMCID: PMC2668763.
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  105. Yi C, Wilker EW, Yaffe MB, Stemmer-Rachamimov A, Kissil JL. Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res. 2008 Oct 01; 68(19):7932-7. PMID: 18829550; PMCID: PMC2707059.
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  108. Mazanka E, Alexander J, Yeh BJ, Charoenpong P, Lowery DM, Yaffe M, Weiss EL. The NDR/LATS family kinase Cbk1 directly controls transcriptional asymmetry. PLoS Biol. 2008 Aug 19; 6(8):e203. PMID: 18715118; PMCID: PMC2517623.
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  109. Tian W, Li XJ, Stull ND, Ming W, Suh CI, Bissonnette SA, Yaffe MB, Grinstein S, Atkinson SJ, Dinauer MC. Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome. Blood. 2008 Nov 01; 112(9):3867-77. PMID: 18711001; PMCID: PMC2572805.
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  113. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007 Nov 30; 131(5):901-14. PMID: 18001825; PMCID: PMC2149842.
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  116. Dai S, Zhang Y, Weimbs T, Yaffe MB, Zhou D. Bacteria-generated PtdIns(3)P recruits VAMP8 to facilitate phagocytosis. Traffic. 2007 Oct; 8(10):1365-74. PMID: 17645435.
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  125. Nishikawa K, Watanabe M, Kita E, Igai K, Omata K, Yaffe MB, Natori Y. A multivalent peptide library approach identifies a novel Shiga toxin inhibitor that induces aberrant cellular transport of the toxin. FASEB J. 2006 Dec; 20(14):2597-9. PMID: 17065223.
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  126. Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006 Aug 01; 66(15):7473-81. PMID: 16885344.
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  128. Cheng C, Yaffe MB, Sharp PA. A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev. 2006 Jul 01; 20(13):1715-20. PMID: 16818603; PMCID: PMC1522067.
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  133. Hong JH, Yaffe MB. TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle. 2006 Jan; 5(2):176-9. PMID: 16397409.
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  146. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro. J Biol Chem. 2005 Mar 18; 280(11):9780-5. PMID: 15640142.
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  148. Rubin BB, Downey GP, Koh A, Degousee N, Ghomashchi F, Nallan L, Stefanski E, Harkin DW, Sun C, Smart BP, Lindsay TF, Cherepanov V, Vachon E, Kelvin D, Sadilek M, Brown GE, Yaffe MB, Plumb J, Grinstein S, Glogauer M, Gelb MH. Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. J Biol Chem. 2005 Mar 04; 280(9):7519-29. PMID: 15475363; PMCID: PMC2409062.
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  154. Dalal SN, Yaffe MB, DeCaprio JA. 14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle. 2004 May; 3(5):672-7. PMID: 15107609.
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  155. Clapperton JA, Manke IA, Lowery DM, Ho T, Haire LF, Yaffe MB, Smerdon SJ. Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol. 2004 Jun; 11(6):512-8. PMID: 15133502.
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  156. Brown GE, Stewart MQ, Bissonnette SA, Elia AE, Wilker E, Yaffe MB. Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem. 2004 Jun 25; 279(26):27059-68. PMID: 15102856.
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  167. Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell. 2003 Oct; 12(4):841-9. PMID: 14580336.
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  168. Vázquez ME, Nitz M, Stehn J, Yaffe MB, Imperiali B. Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations. J Am Chem Soc. 2003 Aug 27; 125(34):10150-1. PMID: 12926919.
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  169. Powell DW, Rane MJ, Joughin BA, Kalmukova R, Hong JH, Tidor B, Dean WL, Pierce WM, Klein JB, Yaffe MB, McLeish KR. Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol. 2003 Aug; 23(15):5376-87. PMID: 12861023; PMCID: PMC165733.
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  170. Obenauer JC, Cantley LC, Yaffe MB. Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 2003 Jul 01; 31(13):3635-41. PMID: 12824383; PMCID: PMC168990.
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  171. Stone J, Gunasekara A, Martin LJ, Yaffe M, Minkin S, Boyd NF. The detection of change in mammographic density. Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):625-30. PMID: 12869401.
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  172. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73. PMID: 12832460.
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  173. Manke IA, Yaffe MB. Chk'n out in mitosis. Cell Cycle. 2003 May-Jun; 2(3):236-7. PMID: 12775938.
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  174. Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science. 2003 Feb 21; 299(5610):1228-31. PMID: 12595692.
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  175. Nguyen A, Yaffe MB. Proteomics and systems biology approaches to signal transduction in sepsis. Crit Care Med. 2003 Jan; 31(1 Suppl):S1-6. PMID: 12544970.
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  176. Yaffe MB. Studying the optimal peptide substrate motifs of protein kinase C using oriented peptide libraries. Methods Mol Biol. 2003; 233:273-85. PMID: 12840514.
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  177. Brown GE, Stewart MQ, Liu H, Ha VL, Yaffe MB. A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell. 2003 Jan; 11(1):35-47. PMID: 12535519.
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  178. Boyd NF, Stone J, Martin LJ, Jong R, Fishell E, Yaffe M, Hammond G, Minkin S. The association of breast mitogens with mammographic densities. Br J Cancer. 2002 Oct 07; 87(8):876-82. PMID: 12373602; PMCID: PMC2376176.
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  179. Yaffe MB. The p47phox PX domain: two heads are better than one! Structure. 2002 Oct; 10(10):1288-90. PMID: 12377114.
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  180. Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ. Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell. 2002 May; 9(5):1045-54. PMID: 12049740.
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  181. Johnson BA, Stehn JR, Yaffe MB, Blackwell TK. Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem. 2002 May 17; 277(20):18029-36. PMID: 11886850.
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  182. Yaffe MB. Phosphotyrosine-binding domains in signal transduction. Nat Rev Mol Cell Biol. 2002 Mar; 3(3):177-86. PMID: 11994738.
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  183. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME, Yaffe MB. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002 Mar 04; 156(5):817-28. PMID: 11864996; PMCID: PMC2173313.
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  184. Yaffe MB. How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett. 2002 Feb 20; 513(1):53-7. PMID: 11911880.
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  185. Yaffe MB. MAGUK SH3 domains--swapped and stranded by their kinases? Structure. 2002 Jan; 10(1):3-5. PMID: 11796103.
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  186. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 01; 20(21):5840-52. PMID: 11689425; PMCID: PMC125701.
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  187. He J, Lau AG, Yaffe MB, Hall RA. Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase. J Biol Chem. 2001 Nov 09; 276(45):41559-65. PMID: 11533036.
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  188. Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nat Cell Biol. 2001 Jul; 3(7):675-8. PMID: 11433300.
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  189. Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nat Biotechnol. 2001 Apr; 19(4):348-53. PMID: 11283593.
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  190. Yaffe MB, Elia AE. Phosphoserine/threonine-binding domains. Curr Opin Cell Biol. 2001 Apr; 13(2):131-8. PMID: 11248545.
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  191. Yaffe MB, Smerdon SJ. PhosphoSerine/threonine binding domains: you can't pSERious? Structure. 2001 Mar 07; 9(3):R33-8. PMID: 11286893.
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  192. Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 2000 Dec 15; 19(24):6778-91. PMID: 11118213; PMCID: PMC305881.
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  193. Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17; 275(46):36108-15. PMID: 10945990.
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  194. Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell. 2000 Nov; 6(5):1169-82. PMID: 11106755.
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  195. Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Mol Cell. 2000 Oct; 6(4):969-74. PMID: 11090635.
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  196. Benzing T, Yaffe MB, Arnould T, Sellin L, Schermer B, Schilling B, Schreiber R, Kunzelmann K, Leparc GG, Kim E, Walz G. 14-3-3 interacts with regulator of G protein signaling proteins and modulates their activity. J Biol Chem. 2000 Sep 08; 275(36):28167-72. PMID: 10862767.
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  197. Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell. 2000 Jul; 6(1):41-51. PMID: 10949026.
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  198. Bedford MT, Frankel A, Yaffe MB, Clarke S, Leder P, Richard S. Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. J Biol Chem. 2000 May 26; 275(21):16030-6. PMID: 10748127.
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  199. Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 07; 275(14):10359-69. PMID: 10744724.
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  200. Obata T, Brown GE, Yaffe MB. MAP kinase pathways activated by stress: the p38 MAPK pathway. Crit Care Med. 2000 Apr; 28(4 Suppl):N67-77. PMID: 10807318.
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  201. Yaffe MB, Fink MP. Cellular signaling in critical care--putting the pieces together. Crit Care Med. 2000 Apr; 28(4 Suppl):N1-2. PMID: 10807311.
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  202. Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. J Biol Chem. 2000 Jan 21; 275(3):2219-30. PMID: 10636929.
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  203. Yaffe MB, Cantley LC. Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods Enzymol. 2000; 328:157-70. PMID: 11075345.
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  204. Durocher D, Smerdon SJ, Yaffe MB, Jackson SP. The FHA domain in DNA repair and checkpoint signaling. Cold Spring Harb Symp Quant Biol. 2000; 65:423-31. PMID: 12760058.
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  205. Yaffe MB, Cantley LC. Signal transduction. Grabbing phosphoproteins. Nature. 1999 Nov 04; 402(6757):30-1. PMID: 10573413.
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  206. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999 Oct; 4(4):555-61. PMID: 10549287.
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  207. Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science. 1999 Sep 24; 285(5436):2129-33. PMID: 10497131.
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  208. Yaffe MB, Xu J, Burke PA, Forse RA, Brown GE. Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. Surgery. 1999 Aug; 126(2):248-54. PMID: 10455891.
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  209. Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Mol Cell. 1999 Aug; 4(2):153-66. PMID: 10488331.
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  210. Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Mol Cell. 1998 Sep; 2(3):353-9. PMID: 9774973.
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  211. Boyd NF, Martin L, Lockwood G, Greenberg C, Yaffe M, Tritchler D. Diet and breast cancer. Nutrition. 1998 Sep; 14(9):722-4. PMID: 9760600.
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  212. Samuels TH, Liu FF, Yaffe M, Haider M. Gestational breast cancer. Can Assoc Radiol J. 1998 Jun; 49(3):172-80. PMID: 9640283.
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  213. Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 1997 Dec 26; 91(7):961-71. PMID: 9428519.
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  214. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60. PMID: 9395400.
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  215. Algenstaedt P, Antonetti DA, Yaffe MB, Kahn CR. Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart. J Biol Chem. 1997 Sep 19; 272(38):23696-702. PMID: 9295312.
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  216. Boyd NF, Greenberg C, Lockwood G, Little L, Martin L, Byng J, Yaffe M, Tritchler D. Effects at two years of a low-fat, high-carbohydrate diet on radiologic features of the breast: results from a randomized trial. Canadian Diet and Breast Cancer Prevention Study Group. J Natl Cancer Inst. 1997 Apr 02; 89(7):488-96. PMID: 9086005.
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  217. Burke PA, Luo M, Zhu J, Yaffe MB, Forse RA. Injury induces rapid changes in hepatocyte nuclear factor-1: DNA binding. Surgery. 1996 Aug; 120(2):374-80; discussion 380-1. PMID: 8751607.
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  218. Boyd NF, Connelly P, Byng J, Yaffe M, Draper H, Little L, Jones D, Martin LJ, Lockwood G, Tritchler D. Plasma lipids, lipoproteins, and mammographic densities. Cancer Epidemiol Biomarkers Prev. 1995 Oct-Nov; 4(7):727-33. PMID: 8672989.
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  219. Burke PA, Drotar M, Luo M, Yaffe M, Forse RA. Rapid modulation of liver-specific transcription factors after injury. Surgery. 1994 Aug; 116(2):285-92; discussion 292-3. PMID: 8047996.
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  220. Sternlicht H, Farr GW, Sternlicht ML, Driscoll JK, Willison K, Yaffe MB. The t-complex polypeptide 1 complex is a chaperonin for tubulin and actin in vivo. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9422-6. PMID: 8105476; PMCID: PMC47580.
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  221. Eckert RL, Yaffe MB, Crish JF, Murthy S, Rorke EA, Welter JF. Involucrin--structure and role in envelope assembly. J Invest Dermatol. 1993 May; 100(5):613-7. PMID: 8098344.
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  222. Yaffe MB, Murthy S, Eckert RL. Evidence that involucrin is a covalently linked constituent of highly purified cultured keratinocyte cornified envelopes. J Invest Dermatol. 1993 Jan; 100(1):3-9. PMID: 8423390.
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  223. Yaffe MB, Farr GW, Miklos D, Horwich AL, Sternlicht ML, Sternlicht H. TCP1 complex is a molecular chaperone in tubulin biogenesis. Nature. 1992 Jul 16; 358(6383):245-8. PMID: 1630491.
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  224. Hoffman P, Yaffe MB, Hoffman BL, Yei S, Wold WS, Carlin C. Characterization of the adenovirus E3 protein that down-regulates the epidermal growth factor receptor. Evidence for intermolecular disulfide bonding and plasma membrane localization. J Biol Chem. 1992 Jul 05; 267(19):13480-7. PMID: 1377684.
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  225. Yaffe MB, Beegen H, Eckert RL. Biophysical characterization of involucrin reveals a molecule ideally suited to function as an intermolecular cross-bridge of the keratinocyte cornified envelope. J Biol Chem. 1992 Jun 15; 267(17):12233-8. PMID: 1601889.
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  226. Farr GW, Yaffe MB, Sternlicht H. Alpha-tubulin influences nucleotide binding to beta-tubulin: an assay using picomoles of unpurified protein. Proc Natl Acad Sci U S A. 1990 Jul; 87(13):5041-5. PMID: 2367522; PMCID: PMC54257.
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  227. Yaffe MB, Levison BS, Szasz J, Sternlicht H. Expression of a human alpha-tubulin: properties of the isolated subunit. Biochemistry. 1988 Mar 22; 27(6):1869-80. PMID: 2897863.
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  228. Sternlicht H, Yaffe MB, Farr GW. A model of the nucleotide-binding site in tubulin. FEBS Lett. 1987 Apr 20; 214(2):226-35. PMID: 3106086.
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  229. Szasz J, Yaffe MB, Elzinga M, Blank GS, Sternlicht H. Microtubule assembly is dependent on a cluster of basic residues in alpha-tubulin. Biochemistry. 1986 Aug 12; 25(16):4572-82. PMID: 3768299.
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  230. Blank GS, Yaffe MB, Szasz J, George E, Rosenberry TL, Sternlicht H. The role of Lys 394 in microtubule assembly. Ann N Y Acad Sci. 1986; 466:467-81. PMID: 3089112.
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