Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael Bruce Yaffe, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Characterizing Cell-Specific Radiation Sensitization Induced by HDAC Inhibition
Summer, 05/29/12 - 08/17/12

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA226898 (YAFFE, MICHAEL B) Dec 7, 2018 - Nov 30, 2023
    NIH
    RNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer Therapies
    Role: Principal Investigator
  2. R35ES028374 (YAFFE, MICHAEL B) Sep 1, 2017 - Jul 31, 2025
    NIH
    Protein Kinase Signaling in the Genotoxic Stress Response
    Role: Principal Investigator
  3. R01CA185137 (CHAREST, ALAIN) Sep 1, 2014 - Aug 31, 2018
    NIH
    (PQB5)Molecular Wiring and Therapeutic Targeting of EGFR and PDGFR Signaling Netw
    Role: Co-Principal Investigator
  4. R01GM104047 (TURK, BENJAMIN E) Sep 10, 2013 - Oct 31, 2018
    NIH
    Modeling human phosphorylation networks through kinome-wide profiling
    Role: Co-Principal Investigator
  5. R21ES020466 (YAFFE, MICHAEL B) Jul 1, 2012 - Jun 30, 2016
    NIH
    Phospho-Binding Ligands and Substrates of BRCA1
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Suarez-Lopez L, Kong YW, Sriram G, Patterson JC, Rosenberg S, Morandell S, Haigis KM, Yaffe MB. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Front Immunol. 2020; 11:607891. PMID: 33708191.
    Citations:    Fields:    
  2. Konecna B, Park J, Kwon WY, Vlkova B, Zhang Q, Huang W, Kim HI, Yaffe MB, Otterbein LE, Itagaki K, Hauser CJ. Monocyte exocytosis of mitochondrial danger-associated molecular patterns in sepsis suppresses neutrophil chemotaxis. J Trauma Acute Care Surg. 2021 01 01; 90(1):46-53. PMID: 33021603.
    Citations:    Fields:    
  3. Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? J Trauma Acute Care Surg. 2020 12; 89(6):991-998. PMID: 33230046.
    Citations:    Fields:    Translation:Humans
  4. Barrett CD, Vigneshwar N, Moore HB, Ghasabyan A, Chandler J, Moore EE, Yaffe MB. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography. Blood Coagul Fibrinolysis. 2020 Dec; 31(8):578-582. PMID: 32732500.
    Citations:    Fields:    
  5. Lam FC, Kong YW, Yaffe MB. Inducing DNA damage through R-loops to kill cancer cells. Mol Cell Oncol. 2020 Nov 20; 8(1):1848233. PMID: 33553604.
    Citations:    
  6. Levy N, Zucco L, Ehrlichman RJ, Hirschberg RE, Hutton Johnson S, Yaffe MB, Ramachandran SK, Bose S, Leibowitz A. Development of Rapid Response Capabilities in a Large COVID-19 Alternate Care Site Using Failure Modes and Effect Analysis with In Situ Simulation. Anesthesiology. 2020 11 01; 133(5):985-996. PMID: 32773686.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  7. Lim DC, Joukov V, Yaffe MB. Are redox changes a critical switch for mitotic progression? Mol Cell Oncol. 2020 Oct 23; 7(6):1832419. PMID: 33235921.
    Citations:    
  8. Kang JH, Katsikis G, Li Z, Sapp KM, Stockslager MA, Lim D, Vander Heiden MG, Yaffe MB, Manalis SR, Miettinen TP. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nat Commun. 2020 10 05; 11(1):4983. PMID: 33020492.
    Citations:    Fields:    Translation:AnimalsCells
  9. Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Ann Surg. 2020 10; 272(4):604-610. PMID: 32932316.
    Citations:    Fields:    Translation:Humans
  10. Barrett CD, Yaffe MB. COVID-19: All the wrong moves in all the wrong places. Sci Signal. 2020 09 15; 13(649). PMID: 32934074.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  11. Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin TEG Rapidly Identifies Trauma Patients at Risk for Massive Transfusion, Mortality and Hyperfibrinolysis: A Diagnostic Tool to Resolve an International Debate on TXA? J Trauma Acute Care Surg. 2020 Sep 09. PMID: 32925578.
    Citations:    Fields:    
  12. Barrett CD, Oren-Grinberg A, Chao E, Moraco AH, Martin MJ, Reddy SH, Ilg AM, Jhunjhunwala R, Uribe M, Moore HB, Moore EE, Baedorf-Kassis EN, Krajewski ML, Talmor DS, Shaefi S, Yaffe MB. Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series. J Trauma Acute Care Surg. 2020 09; 89(3):453-457. PMID: 32427773.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  13. Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Cell Rep. 2020 08 25; 32(8):108064. PMID: 32846122.
    Citations: 1     Fields:    
  14. Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nat Commun. 2020 08 17; 11(1):4124. PMID: 32807787.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Lam FC, Kong YW, Huang Q, Vu Han TL, Maffa AD, Kasper EM, Yaffe MB. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage. Nat Commun. 2020 08 14; 11(1):4083. PMID: 32796829.
    Citations: 1     Fields:    Translation:HumansCells
  16. Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. Redox priming promotes Aurora A activation during mitosis. Sci Signal. 2020 07 21; 13(641). PMID: 32694171.
    Citations: 1     Fields:    
  17. Proctor EA, Dineen SM, Van Nostrand SC, Kuhn MK, Barrett CD, Brubaker DK, Yaffe MB, Lauffenburger DA, Leon LR. Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model. J Thromb Haemost. 2020 08; 18(8):1900-1910. PMID: 32367690.
    Citations: 2     Fields:    
  18. Haider N, Dutt P, van de Kooij B, Ho J, Palomero L, Pujana MA, Yaffe M, Stambolic V. NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Oncogene. 2020 07; 39(30):5252-5266. PMID: 32561851.
    Citations: 2     Fields:    Translation:HumansCells
  19. Barrett CD, Moore HB, Yaffe MB, Moore EE. ISTH interim guidance on recognition and management of coagulopathy in COVID-19: A comment. J Thromb Haemost. 2020 08; 18(8):2060-2063. PMID: 32302462.
    Citations: 55     Fields:    Translation:HumansCellsPHPublic Health
  20. Barrett CD, Moore HB, Moore EE, McIntyre RC, Moore PK, Burke J, Hua F, Apgar J, Talmor DS, Sauaia A, Liptzin DR, Veress LA, Yaffe MB. Fibrinolytic therapy for refractory COVID-19 acute respiratory distress syndrome: Scientific rationale and review. Res Pract Thromb Haemost. 2020 May; 4(4):524-531. PMID: 32542213.
    Citations: 10     
  21. Moore HB, Barrett CD, Moore EE, McIntyre RC, Moore PK, Talmor DS, Moore FA, Yaffe MB. Is there a role for tissue plasminogen activator as a novel treatment for refractory COVID-19 associated acute respiratory distress syndrome? J Trauma Acute Care Surg. 2020 06; 88(6):713-714. PMID: 32281766.
    Citations: 36     Fields:    Translation:HumansCellsPHPublic Health
  22. Moore HB, Barrett CD, Moore EE, Jhunjhnuwala R, McIntyre RC, Moore PK, Wang J, Hajizadeh N, Talmor DS, Sauaia A, Yaffe MB. STudy of Alteplase for Respiratory failure in SARS-Cov2/COVID-19: Study Design of the Phase IIa STARS Trial. Res Pract Thromb Haemost. 2020 May 21. PMID: 32838109.
    Citations: 5     
  23. Wang J, Hajizadeh N, Moore EE, McIntyre RC, Moore PK, Veress LA, Yaffe MB, Moore HB, Barrett CD. Tissue plasminogen activator (tPA) treatment for COVID-19 associated acute respiratory distress syndrome (ARDS): A case series. J Thromb Haemost. 2020 07; 18(7):1752-1755. PMID: 32267998.
    Citations: 154     Fields:    Translation:HumansCellsPHPublic Health
  24. Choudhury R, Barrett CD, Moore HB, Moore EE, McIntyre RC, Moore PK, Talmor DS, Nydam TL, Yaffe MB. Salvage use of tissue plasminogen activator (tPA) in the setting of acute respiratory distress syndrome (ARDS) due to COVID-19 in the USA: a Markov decision analysis. World J Emerg Surg. 2020 04 20; 15(1):29. PMID: 32312290.
    Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
  25. Barrett CD, Yaffe MB. Influence of tranexamic acid on the complement system in trauma. ANZ J Surg. 2020 04; 90(4):418-420. PMID: 32339419.
    Citations:    Fields:    
  26. Barrett CD, Kong YW, Yaffe MB. Influence of Tranexamic Acid on Inflammatory Signaling in Trauma. Semin Thromb Hemost. 2020 Mar; 46(2):183-188. PMID: 32160643.
    Citations:    Fields:    Translation:HumansCells
  27. Cahill LA, Guo F, Nguyen J, Zhang F, Seshadri A, Keegan J, Hauser CJ, Otterbein LE, Robson S, Shaefi S, Yaffe MB, Lederer JA. Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets. Injury. 2020 Apr; 51(4):819-829. PMID: 32171537.
    Citations:    Fields:    Translation:HumansCells
  28. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Crit Care Med. 2020 02; 48(2):e123-e132. PMID: 31939811.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Dhara S, Moore EE, Yaffe MB, Moore HB, Barrett CD. Modern Management of Bleeding, Clotting, and Coagulopathy in Trauma Patients: What Is the Role of Viscoelastic Assays? Curr Trauma Rep. 2020 Mar; 6(1):69-81. PMID: 32864298.
    Citations: 2