Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Michael Bruce Yaffe, M.D., Ph.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Characterizing Cell-Specific Radiation Sensitization Induced by HDAC Inhibition
Summer, 05/29/12 - 08/17/12

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA226898 (YAFFE, MICHAEL B) Dec 7, 2018 - Nov 30, 2023
    NIH
    RNA-Binding Proteins as Molecular Integrators that Control the Response of HGSOC to Ant-Cancer Therapies
    Role: Principal Investigator
  2. R35ES028374 (YAFFE, MICHAEL B) Sep 1, 2017 - Jul 31, 2025
    NIH
    Protein Kinase Signaling in the Genotoxic Stress Response
    Role: Principal Investigator
  3. R01CA185137 (CHAREST, ALAIN) Sep 1, 2014 - Aug 31, 2018
    NIH
    (PQB5)Molecular Wiring and Therapeutic Targeting of EGFR and PDGFR Signaling Netw
    Role: Co-Principal Investigator
  4. R01GM104047 (TURK, BENJAMIN E) Sep 10, 2013 - Oct 31, 2018
    NIH
    Modeling human phosphorylation networks through kinome-wide profiling
    Role: Co-Principal Investigator
  5. R21ES020466 (YAFFE, MICHAEL B) Jul 1, 2012 - Jun 30, 2016
    NIH
    Phospho-Binding Ligands and Substrates of BRCA1
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Barrett CD, Moore HB, Moore EE, Wang DJ, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre R, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas I, Schmidt E, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. STudy of Alteplase for Respiratory failure in SARS-Cov2 COVID-19 (STARS): A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized, Controlled Trial. Chest. 2021 Sep 27. PMID: 34592318.
    Citations:    Fields:    
  2. Hymel D, Tsuji K, Grant RA, Chingle RM, Kunciw DL, Yaffe MB, Burke TR. Design and synthesis of a new orthogonally protected glutamic acid analog and its use in the preparation of high affinity polo-like kinase 1 polo-box domain - binding peptide macrocycles. Org Biomol Chem. 2021 Sep 22; 19(36):7843-7854. PMID: 34346472.
    Citations:    Fields:    
  3. Lee GR, Gallo D, Alves de Souza RW, Tiwari-Heckler S, Csizmadia E, Harbison JD, Shankar S, Banner-Goodspeed V, Yaffe MB, Longhi MS, Hauser CJ, Otterbein LE. Trauma-induced heme release increases susceptibility to bacterial infection. JCI Insight. 2021 Sep 14. PMID: 34520397.
    Citations:    Fields:    
  4. Emmons TR, Giridharan T, Singel KL, Khan ANH, Ricciuti J, Howard K, Silva-Del Toro SL, Debreceni IL, Aarts CEM, Brouwer MC, Suzuki S, Kuijpers TW, Jongerius I, Allen LH, Ferreira VP, Schubart A, Sellner H, Eder J, Holland SM, Ram S, Lederer JA, Eng KH, Moysich KB, Odunsi K, Yaffe MB, Zsiros E, Segal BH. Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. Cancer Immunol Res. 2021 Jul; 9(7):790-810. PMID: 33990375.
    Citations: 1     Fields:    
  5. Gaestel M, Nebreda AR, Yaffe MB. Cytokine Storm. N Engl J Med. 2021 Apr 22; 384(16):e59. PMID: 33882214.
    Citations: 1     Fields:    Translation:Humans
  6. Suarez-Lopez L, Kong YW, Sriram G, Patterson JC, Rosenberg S, Morandell S, Haigis KM, Yaffe MB. MAPKAP Kinase-2 Drives Expression of Angiogenic Factors by Tumor-Associated Macrophages in a Model of Inflammation-Induced Colon Cancer. Front Immunol. 2020; 11:607891. PMID: 33708191.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Konecna B, Park J, Kwon WY, Vlkova B, Zhang Q, Huang W, Kim HI, Yaffe MB, Otterbein LE, Itagaki K, Hauser CJ. Monocyte exocytosis of mitochondrial danger-associated molecular patterns in sepsis suppresses neutrophil chemotaxis. J Trauma Acute Care Surg. 2021 01 01; 90(1):46-53. PMID: 33021603.
    Citations: 2     Fields:    Translation:HumansCells
  8. Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? J Trauma Acute Care Surg. 2020 12; 89(6):991-998. PMID: 33230046.
    Citations:    Fields:    Translation:Humans
  9. Barrett CD, Vigneshwar N, Moore HB, Ghasabyan A, Chandler J, Moore EE, Yaffe MB. Tranexamic acid is associated with reduced complement activation in trauma patients with hemorrhagic shock and hyperfibrinolysis on thromboelastography. Blood Coagul Fibrinolysis. 2020 Dec; 31(8):578-582. PMID: 32732500.
    Citations: 1     Fields:    Translation:Humans
  10. Lam FC, Kong YW, Yaffe MB. Inducing DNA damage through R-loops to kill cancer cells. Mol Cell Oncol. 2020 Nov 20; 8(1):1848233. PMID: 33553604.
    Citations: 2     
  11. Levy N, Zucco L, Ehrlichman RJ, Hirschberg RE, Hutton Johnson S, Yaffe MB, Ramachandran SK, Bose S, Leibowitz A. Development of Rapid Response Capabilities in a Large COVID-19 Alternate Care Site Using Failure Modes and Effect Analysis with In Situ Simulation. Anesthesiology. 2020 11 01; 133(5):985-996. PMID: 32773686.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  12. Lim DC, Joukov V, Yaffe MB. Are redox changes a critical switch for mitotic progression? Mol Cell Oncol. 2020 Oct 23; 7(6):1832419. PMID: 33235921.
    Citations:    
  13. Kang JH, Katsikis G, Li Z, Sapp KM, Stockslager MA, Lim D, Vander Heiden MG, Yaffe MB, Manalis SR, Miettinen TP. Monitoring and modeling of lymphocytic leukemia cell bioenergetics reveals decreased ATP synthesis during cell division. Nat Commun. 2020 10 05; 11(1):4983. PMID: 33020492.
    Citations:    Fields:    Translation:AnimalsCells
  14. Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Ann Surg. 2020 10; 272(4):604-610. PMID: 32932316.
    Citations: 1     Fields:    Translation:Humans
  15. Barrett CD, Yaffe MB. COVID-19: All the wrong moves in all the wrong places. Sci Signal. 2020 09 15; 13(649). PMID: 32934074.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  16. Barrett CD, Moore HB, Vigneshwar N, Dhara S, Chandler J, Chapman MP, Sauaia A, Moore EE, Yaffe MB. Plasmin TEG Rapidly Identifies Trauma Patients at Risk for Massive Transfusion, Mortality and Hyperfibrinolysis: A Diagnostic Tool to Resolve an International Debate on TXA? J Trauma Acute Care Surg. 2020 Sep 09. PMID: 32925578.
    Citations:    Fields:    
  17. Barrett CD, Oren-Grinberg A, Chao E, Moraco AH, Martin MJ, Reddy SH, Ilg AM, Jhunjhunwala R, Uribe M, Moore HB, Moore EE, Baedorf-Kassis EN, Krajewski ML, Talmor DS, Shaefi S, Yaffe MB. Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series. J Trauma Acute Care Surg. 2020 09; 89(3):453-457. PMID: 32427773.
    Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
  18. Krismer K, Bird MA, Varmeh S, Handly ED, Gattinger A, Bernwinkler T, Anderson DA, Heinzel A, Joughin BA, Kong YW, Cannell IG, Yaffe MB. Transite: A Computational Motif-Based Analysis Platform That Identifies RNA-Binding Proteins Modulating Changes in Gene Expression. Cell Rep. 2020 08 25; 32(8):108064. PMID: 32846122.
    Citations: 2     Fields:    Translation:Humans
  19. Kong YW, Dreaden EC, Morandell S, Zhou W, Dhara SS, Sriram G, Lam FC, Patterson JC, Quadir M, Dinh A, Shopsowitz KE, Varmeh S, Yilmaz ÖH, Lippard SJ, Reinhardt HC, Hemann MT, Hammond PT, Yaffe MB. Enhancing chemotherapy response through augmented synthetic lethality by co-targeting nucleotide excision repair and cell-cycle checkpoints. Nat Commun. 2020 08 17; 11(1):4124. PMID: 32807787.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Lam FC, Kong YW, Huang Q, Vu Han TL, Maffa AD, Kasper EM, Yaffe MB. BRD4 prevents the accumulation of R-loops and protects against transcription-replication collision events and DNA damage. Nat Commun. 2020 08 14; 11(1):4083. PMID: 32796829.
    Citations: 12     Fields:    Translation:HumansCells
  21. Lim DC, Joukov V, Rettenmaier TJ, Kumagai A, Dunphy WG, Wells JA, Yaffe MB. Redox priming promotes Aurora A activation during mitosis. Sci Signal. 2020 07 21; 13(641). PMID: 32694171.
    Citations: 2