Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ken Arai, Ph.D.

Co-Author

This page shows the publications co-authored by Ken Arai and Eng Lo.
Connection Strength

14.684
  1. Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche. J Cereb Blood Flow Metab. 2021 08; 41(8):2132-2133.
    View in: PubMed
    Score: 0.970
  2. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8.
    View in: PubMed
    Score: 0.487
  3. Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res. 2010 Mar; 88(4):758-63.
    View in: PubMed
    Score: 0.446
  4. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009 Oct 24; 1:6.
    View in: PubMed
    Score: 0.436
  5. Oligovascular signaling in white matter stroke. Biol Pharm Bull. 2009 Oct; 32(10):1639-44.
    View in: PubMed
    Score: 0.434
  6. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009 Sep; 276(17):4644-52.
    View in: PubMed
    Score: 0.429
  7. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009 Apr 08; 29(14):4351-5.
    View in: PubMed
    Score: 0.420
  8. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9.
    View in: PubMed
    Score: 0.296
  9. Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003 Sep; 43(3):254-64.
    View in: PubMed
    Score: 0.285
  10. Transcriptome Profiling of Mouse Corpus Callosum After Cerebral Hypoperfusion. Front Cell Dev Biol. 2021; 9:685261.
    View in: PubMed
    Score: 0.244
  11. Mature Adult Mice With Exercise-Preconditioning Show Better Recovery After Intracerebral Hemorrhage. Stroke. 2021 May; 52(5):1861-1865.
    View in: PubMed
    Score: 0.241
  12. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem Cell Rev Rep. 2021 Aug; 17(4):1446-1455.
    View in: PubMed
    Score: 0.238
  13. Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke. CNS Neurosci Ther. 2021 01; 27(1):60-70.
    View in: PubMed
    Score: 0.236
  14. AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. Int J Mol Sci. 2020 Nov 28; 21(23).
    View in: PubMed
    Score: 0.235
  15. Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase-9 secretion in cultured rat primary microglial cells. Glia. 2020 07; 68(7):1435-1444.
    View in: PubMed
    Score: 0.223
  16. Heterogeneity of microglia and their differential roles in white matter pathology. CNS Neurosci Ther. 2019 12; 25(12):1290-1298.
    View in: PubMed
    Score: 0.219
  17. Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion. Transl Stroke Res. 2020 06; 11(3):496-502.
    View in: PubMed
    Score: 0.217
  18. Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem Cells Transl Med. 2019 12; 8(12):1242-1248.
    View in: PubMed
    Score: 0.216
  19. Brief review: Can modulating DNA methylation state help the clinical application of oligodendrocyte precursor cells as a source of stem cell therapy? Brain Res. 2019 11 15; 1723:146386.
    View in: PubMed
    Score: 0.215
  20. Effects of angiotensin-II on brain endothelial cell permeability via PPARalpha regulation of para- and trans-cellular pathways. Brain Res. 2019 11 01; 1722:146353.
    View in: PubMed
    Score: 0.214
  21. Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells. Glia. 2019 04; 67(4):718-728.
    View in: PubMed
    Score: 0.205
  22. Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab. 2018 12; 38(12):2236-2250.
    View in: PubMed
    Score: 0.201
  23. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 09; 36(9):1404-1410.
    View in: PubMed
    Score: 0.199
  24. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 07; 146(2):160-172.
    View in: PubMed
    Score: 0.197
  25. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells. 2018 05; 36(5):751-760.
    View in: PubMed
    Score: 0.193
  26. Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress. Neurosci Lett. 2018 03 06; 668:120-125.
    View in: PubMed
    Score: 0.193
  27. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341.
    View in: PubMed
    Score: 0.176
  28. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 2016 10 28; 633:7-13.
    View in: PubMed
    Score: 0.175
  29. Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke. 2016 Apr; 47(4):1094-100.
    View in: PubMed
    Score: 0.169
  30. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016; 25(4):705-14.
    View in: PubMed
    Score: 0.168
  31. Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury. Neurosci Res. 2016 May; 106:66-9.
    View in: PubMed
    Score: 0.167
  32. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2.
    View in: PubMed
    Score: 0.165
  33. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93.
    View in: PubMed
    Score: 0.164
  34. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One. 2015; 10(9):e0138724.
    View in: PubMed
    Score: 0.164
  35. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4.
    View in: PubMed
    Score: 0.163
  36. Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro. Stem Cell Res. 2015 Jul; 15(1):68-74.
    View in: PubMed
    Score: 0.160
  37. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174.
    View in: PubMed
    Score: 0.152
  38. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8.
    View in: PubMed
    Score: 0.146
  39. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci. 2013 Dec 26; 7:275.
    View in: PubMed
    Score: 0.145
  40. Crosstalk between cerebral endothelium and oligodendrocyte. Cell Mol Life Sci. 2014 Mar; 71(6):1055-66.
    View in: PubMed
    Score: 0.144
  41. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21.
    View in: PubMed
    Score: 0.143
  42. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8.
    View in: PubMed
    Score: 0.141
  43. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15.
    View in: PubMed
    Score: 0.139
  44. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203.
    View in: PubMed
    Score: 0.137
  45. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6.
    View in: PubMed
    Score: 0.136
  46. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8.
    View in: PubMed
    Score: 0.136
  47. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80.
    View in: PubMed
    Score: 0.136
  48. Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci. 2012 Jun 13; 32(24):8112-5.
    View in: PubMed
    Score: 0.131
  49. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30.
    View in: PubMed
    Score: 0.130
  50. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10.
    View in: PubMed
    Score: 0.130
  51. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81.
    View in: PubMed
    Score: 0.128
  52. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6.
    View in: PubMed
    Score: 0.128
  53. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70.
    View in: PubMed
    Score: 0.123
  54. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72.
    View in: PubMed
    Score: 0.120
  55. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15.
    View in: PubMed
    Score: 0.114
  56. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7.
    View in: PubMed
    Score: 0.112
  57. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41.
    View in: PubMed
    Score: 0.109
  58. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7.
    View in: PubMed
    Score: 0.109
  59. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009 Jul 15; 10:79.
    View in: PubMed
    Score: 0.107
  60. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23.
    View in: PubMed
    Score: 0.105
  61. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21.
    View in: PubMed
    Score: 0.105
  62. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43.
    View in: PubMed
    Score: 0.104
  63. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5.
    View in: PubMed
    Score: 0.102
  64. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404.
    View in: PubMed
    Score: 0.101
  65. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9.
    View in: PubMed
    Score: 0.097
  66. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8.
    View in: PubMed
    Score: 0.088
  67. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9.
    View in: PubMed
    Score: 0.081
  68. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7.
    View in: PubMed
    Score: 0.071
  69. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Sci Transl Med. 2021 06 02; 13(596).
    View in: PubMed
    Score: 0.061
  70. ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood brain barrier modulation. J Cereb Blood Flow Metab. 2021 Sep; 41(9):2242-2255.
    View in: PubMed
    Score: 0.060
  71. Blood-Brain Barrier Mechanisms in Stroke and Trauma. Handb Exp Pharmacol. 2021 Feb 13.
    View in: PubMed
    Score: 0.060
  72. Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes. J Cereb Blood Flow Metab. 2021 07; 41(7):1523-1535.
    View in: PubMed
    Score: 0.059
  73. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab. 2020 12; 40(1_suppl):S34-S48.
    View in: PubMed
    Score: 0.057
  74. Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology. 2020 03 24; 94(12):e1281-e1293.
    View in: PubMed
    Score: 0.056
  75. Sex-specific differences in white matter microvascular integrity after ischaemic stroke. Stroke Vasc Neurol. 2019 Dec; 4(4):198-205.
    View in: PubMed
    Score: 0.054
  76. Early molecular oxidative stress biomarkers of ischemic penumbra in acute stroke. Neurology. 2019 09 24; 93(13):e1288-e1298.
    View in: PubMed
    Score: 0.054
  77. Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion. J Cereb Blood Flow Metab. 2020 03; 40(3):501-512.
    View in: PubMed
    Score: 0.052
  78. Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke. 2018 04; 49(4):1003-1010.
    View in: PubMed
    Score: 0.049
  79. Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke. 2018 03; 49(3):630-637.
    View in: PubMed
    Score: 0.048
  80. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2018 01; 38(1):75-86.
    View in: PubMed
    Score: 0.046
  81. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211.
    View in: PubMed
    Score: 0.044
  82. Neuregulin1-ß decreases interleukin-1ß-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016 Jan; 136(2):250-7.
    View in: PubMed
    Score: 0.041
  83. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222.
    View in: PubMed
    Score: 0.041
  84. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8.
    View in: PubMed
    Score: 0.039
  85. Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury. Nat Commun. 2014 Sep 17; 5:4952.
    View in: PubMed
    Score: 0.038
  86. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular ß-amyloid. Ann Clin Transl Neurol. 2014 Aug; 1(8):519-33.
    View in: PubMed
    Score: 0.038
  87. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 08; 289(32):21926-36.
    View in: PubMed
    Score: 0.038
  88. AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014; 9(4):e94695.
    View in: PubMed
    Score: 0.037
  89. White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Jul; 23(6):1300-6.
    View in: PubMed
    Score: 0.037
  90. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke. 2013 Feb; 44(2):505-11.
    View in: PubMed
    Score: 0.034
  91. Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step. Methods Mol Biol. 2013; 1013:227-33.
    View in: PubMed
    Score: 0.034
  92. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85.
    View in: PubMed
    Score: 0.033
  93. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7.
    View in: PubMed
    Score: 0.031
  94. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51).
    View in: PubMed
    Score: 0.030
  95. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9.
    View in: PubMed
    Score: 0.029
  96. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67.
    View in: PubMed
    Score: 0.028
  97. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9.
    View in: PubMed
    Score: 0.027
  98. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43.
    View in: PubMed
    Score: 0.025
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.