Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ken Arai, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG066478 (ARAI, KEN) Feb 1, 2020 - Jan 31, 2022
    Aging dampens compensatory angiogenesis via downregulation of VEGF signaling in subcortical ischemic vascular dementia
    Role: Principal Investigator
  2. R01NS113556 (ARAI, KEN) Jul 1, 2019 - Jun 30, 2024
    Oligodendrocyte precursor cells regulate white matter remodeling in vascular cognitive impairment and dementia
    Role: Principal Investigator
  3. R01NS065089 (ARAI, KEN) Apr 1, 2009 - Jun 30, 2021
    Oligo-Vascular Signaling in Stroke
    Role: Principal Investigator
  4. P01NS055104 (LO, ENG H.) Jul 1, 2007 - Apr 30, 2020
    Remodeling and recovery in the neurovascular unit
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kinoshita K, Chung KK, Katsuki H, Arai K. Therapeutic potential of prophylactic exercise for intracerebral hemorrhage. Neural Regen Res. 2022 Jul; 17(7):1484-1485. PMID: 34916426.
  2. Egawa N, Hamanaka G, Chung KK, Ishikawa H, Shindo A, Maki T, Takahashi R, Inoue H, Lo EH, Arai K. High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells. Int J Mol Sci. 2022 Feb 17; 23(4). PMID: 35216347.
    Citations:    Fields:    
  3. Ohtomo R, Ishikawa H, Kinoshita K, Chung KK, Hamanaka G, Ohtomo G, Takase H, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K. Treadmill Exercise During Cerebral Hypoperfusion Has Only Limited Effects on Cognitive Function in Middle-Aged Subcortical Ischemic Vascular Dementia Mice. Front Aging Neurosci. 2021; 13:756537. PMID: 34992525.
  4. Takase H, Hamanaka G, Ohtomo R, Ishikawa H, Chung KK, Mandeville ET, Lok J, Fornage M, Herrup K, Tse KH, Lo EH, Arai K. Transcriptome Profiling of Mouse Corpus Callosum After Cerebral Hypoperfusion. Front Cell Dev Biol. 2021; 9:685261. PMID: 34222254.
    Citations: 1     
  5. Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, Tsai CY, Bassal MA, Herbert MK, Washida K, Angeli P, Kozono S, Stucky JE, Baxley S, Lin YM, Sun Y, Rotenberg A, Caldarone BJ, Bigio EH, Chen X, Tenen DG, Zeidel M, Lo EH, Zhou XZ, Lu KP. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Sci Transl Med. 2021 06 02; 13(596). PMID: 34078745.
    Citations: 2     Fields:    Translation:HumansAnimals
  6. Arai K, Lo EH. Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche. J Cereb Blood Flow Metab. 2021 08; 41(8):2132-2133. PMID: 33969732.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Hamanaka G, Chung KK, Arai K. Do phagocytotic mechanisms regulate soluble factor secretion in microglia? Neural Regen Res. 2021 May; 16(5):974-975. PMID: 33229739.
  8. Kinoshita K, Hamanaka G, Ohtomo R, Takase H, Chung KK, Lok J, Lo EH, Katsuki H, Arai K. Mature Adult Mice With Exercise-Preconditioning Show Better Recovery After Intracerebral Hemorrhage. Stroke. 2021 05; 52(5):1861-1865. PMID: 33840224.
    Citations: 3     Fields:    Translation:AnimalsCells
  9. Wu L, Islam MR, Lee J, Takase H, Guo S, Andrews AM, Buzhdygan TP, Mathew J, Li W, Arai K, Lo EH, Ramirez SH, Lok J. ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood brain barrier modulation. J Cereb Blood Flow Metab. 2021 09; 41(9):2242-2255. PMID: 33583260.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Li W, Cao F, Takase H, Arai K, Lo EH, Lok J. Blood-Brain Barrier Mechanisms in Stroke and Trauma. Handb Exp Pharmacol. 2021 Feb 13. PMID: 33580391.
    Citations: 2     Fields:    
  11. Takase H, Hamanaka G, Ohtomo R, Park JH, Chung KK, Gelman IH, Kim KW, Lok J, Lo EH, Arai K. Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum. Stem Cell Rev Rep. 2021 08; 17(4):1446-1455. PMID: 33492625.
    Citations:    Fields:    Translation:AnimalsCells
  12. Shindo A, Takase H, Hamanaka G, Chung KK, Mandeville ET, Egawa N, Maki T, Borlongan M, Takahashi R, Lok J, Tomimoto H, Lo EH, Arai K. Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke. CNS Neurosci Ther. 2021 01; 27(1):60-70. PMID: 33314664.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Seo JH, Maki T, Miyamoto N, Choi YK, Chung KK, Hamanaka G, Park JH, Mandeville ET, Takase H, Hayakawa K, Lok J, Gelman IH, Kim KW, Lo EH, Arai K. AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. Int J Mol Sci. 2020 Nov 28; 21(23). PMID: 33260683.
    Citations: 4     Fields:    Translation:Animals
  14. Park JH, Nakamura Y, Li W, Hamanaka G, Arai K, Lo EH, Hayakawa K. Effects of O-GlcNAcylation on functional mitochondrial transfer from astrocytes. J Cereb Blood Flow Metab. 2021 07; 41(7):1523-1535. PMID: 33153373.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Islam MR, Luo R, Valaris S, Haley EB, Takase H, Chen YI, Dickerson BC, Schon K, Arai K, Nguyen CT, Wrann CD. Diffusion tensor-MRI detects exercise-induced neuroplasticity in the hippocampal microstructure in mice. Brain Plast. 2020 Oct 01; 5(2):147-159. PMID: 33282678.
    Citations: 3     
  16. Arai K. Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease? J Cereb Blood Flow Metab. 2020 08; 40(8):1735-1736. PMID: 32674700.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Kinoshita K, Ohtomo R, Takase H, Hamanaka G, Chung KK, Lok J, Katsuki H, Arai K. Different responses after intracerebral hemorrhage between young and early middle-aged mice. Neurosci Lett. 2020 09 14; 735:135249. PMID: 32673691.
    Citations: 2     Fields:    Translation:Animals
  18. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab. 2020 12; 40(1_suppl):S34-S48. PMID: 33208001.
    Citations: 15     Fields:    Translation:AnimalsCells
  19. Takase H, Chou SH, Hamanaka G, Ohtomo R, Islam MR, Lee JW, Hsu L, Mathew J, Reyes-Bricio E, Hayakawa K, Xing C, Ning MM, Wang X, Arai K, Lo EH, Lok J. Soluble vascular endothelial-cadherin in CSF after subarachnoid hemorrhage. Neurology. 2020 03 24; 94(12):e1281-e1293. PMID: 32107323.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Hamanaka G, Kubo T, Ohtomo R, Takase H, Reyes-Bricio E, Oribe S, Osumi N, Lok J, Lo EH, Arai K. Microglial responses after phagocytosis: Escherichia coli bioparticles, but not cell debris or amyloid beta, induce matrix metalloproteinase-9 secretion in cultured rat primary microglial cells. Glia. 2020 07; 68(7):1435-1444. PMID: 32057146.
    Citations: 3     Fields:    Translation:AnimalsCells
  21. Taniguchi M, Ueda Y, Matsushita M, Nagaya S, Hashizume C, Arai K, Kabayama K, Fukase K, Watanabe K, Wardhani LO, Hayashi K, Okazaki T. Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM-1 reduction. FASEB J. 2020 03; 34(3):3838-3854. PMID: 31970839.
    Citations: 4     Fields:    Translation:AnimalsCells
  22. Ohtomo R, Arai K. Recent updates on mechanisms of cell-cell interaction in oligodendrocyte regeneration after white matter injury. Neurosci Lett. 2020 01 10; 715:134650. PMID: 31770564.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Lee J, Hamanaka G, Lo EH, Arai K. Heterogeneity of microglia and their differential roles in white matter pathology. CNS Neurosci Ther. 2019 12; 25(12):1290-1298. PMID: 31733036.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  24. Ohtomo R, Kinoshita K, Ohtomo G, Takase H, Hamanaka G, Washida K, Islam MR, Wrann CD, Katsuki H, Iwata A, Lok J, Lo EH, Arai K. Treadmill Exercise Suppresses Cognitive Decline and Increases White Matter Oligodendrocyte Precursor Cells in a Mouse Model of Prolonged Cerebral Hypoperfusion. Transl Stroke Res. 2020 06; 11(3):496-502. PMID: 31606888.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Chan SJ, Niu W, Hayakawa K, Hamanaka G, Wang X, Cheah PS, Guo S, Yu Z, Arai K, Selim MH, Kurisawa M, Spector M, Lo EH. Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem Cells Transl Med. 2019 12; 8(12):1242-1248. PMID: 31483567.
    Citations: 5     Fields:    Translation:AnimalsCells
  26. Etherton MR, Wu O, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJRJ, Lauer A, Arai K, Lo EH, Feske SK, Furie KL, Rost NS. Sex-specific differences in white matter microvascular integrity after ischaemic stroke. Stroke Vasc Neurol. 2019 Dec; 4(4):198-205. PMID: 32030203.
    Citations: 2     Fields:    Translation:Humans
  27. Lorenzano S, Rost NS, Khan M, Li H, Batista LM, Chutinet A, Green RE, Thankachan TK, Thornell B, Muzikansky A, Arai K, Som AT, Pham LD, Wu O, Harris GJ, Lo EH, Blumberg JB, Milbury PE, Feske SK, Furie KL. Early molecular oxidative stress biomarkers of ischemic penumbra in acute stroke. Neurology. 2019 09 24; 93(13):e1288-e1298. PMID: 31455665.
    Citations: 8     Fields:    Translation:Humans
  28. Egawa N, Chung KK, Takahashi R, Lo EH, Inoue H, Arai K. Brief review: Can modulating DNA methylation state help the clinical application of oligodendrocyte precursor cells as a source of stem cell therapy? Brain Res. 2019 11 15; 1723:146386. PMID: 31419426.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  29. Guo S, Som AT, Arai K, Lo EH. Effects of angiotensin-II on brain endothelial cell permeability via PPARalpha regulation of para- and trans-cellular pathways. Brain Res. 2019 11 01; 1722:146353. PMID: 31356784.
    Citations: 9     Fields:    Translation:HumansCells
  30. Li B, Ohtomo R, Thunemann M, Adams SR, Yang J, Fu B, Yaseen MA, Ran C, Polimeni JR, Boas DA, Devor A, Lo EH, Arai K, Sakadžic S. Two-photon microscopic imaging of capillary red blood cell flux in mouse brain reveals vulnerability of cerebral white matter to hypoperfusion. J Cereb Blood Flow Metab. 2020 03; 40(3):501-512. PMID: 30829101.
    Citations: 8     Fields:    Translation:AnimalsCells
  31. Arai K. Stroke Literature Synopses: Basic Science (2018/Oct). Stroke. 2019 Jan; 50(1):e2-e3. PMID: 30853724.
  32. Egawa N, Shindo A, Hikawa R, Kinoshita H, Liang AC, Itoh K, Lok J, Maki T, Takahashi R, Lo EH, Arai K. Differential roles of epigenetic regulators in the survival and differentiation of oligodendrocyte precursor cells. Glia. 2019 04; 67(4):718-728. PMID: 30793389.
    Citations: 16     Fields:    Translation:AnimalsCells
  33. Hamanaka G, Ohtomo R, Takase H, Lok J, Arai K. White-matter repair: Interaction between oligodendrocytes and the neurovascular unit. Brain Circ. 2018 Jul-Sep; 4(3):118-123. PMID: 30450418.
    Citations: 15     
  34. Nihei W, Nagafuku M, Hayamizu H, Odagiri Y, Tamura Y, Kikuchi Y, Veillon L, Kanoh H, Inamori KI, Arai K, Kabayama K, Fukase K, Inokuchi JI. NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains. J Lipid Res. 2018 11; 59(11):2181-2187. PMID: 30242108.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  35. Takase H, Lok J, Arai K. A radical scavenger edaravone and oligodendrocyte protection/regeneration. Neural Regen Res. 2018 Sep; 13(9):1550-1551. PMID: 30127114.
  36. Guo S, Tjärnlund-Wolf A, Deng W, Tejima-Mandeville E, Lo LJ, Xing C, Arai K, Ning M, Zhou Y, Lo EH. Comparative transcriptome of neurons after oxygen-glucose deprivation: Potential differences in neuroprotection versus reperfusion. J Cereb Blood Flow Metab. 2018 12; 38(12):2236-2250. PMID: 30152713.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Arai K. Stroke Literature Synopses: Basic Science (2018/May). Stroke. 2018 Aug; 49(8):e270. PMID: 30473590.
    Citations:    Fields:    
  38. Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 09; 36(9):1404-1410. PMID: 29781122.
    Citations: 44     Fields:    Translation:HumansCells
  39. Hamanaka G, Ohtomo R, Takase H, Lok J, Arai K. Role of oligodendrocyte-neurovascular unit in white matter repair. Neurosci Lett. 2018 09 25; 684:175-180. PMID: 30006018.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  40. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2018 Jul 05. PMID: 29976580.
  41. Ohtomo R, Iwata A, Arai K. Molecular Mechanisms of Oligodendrocyte Regeneration in White Matter-Related Diseases. Int J Mol Sci. 2018 06 12; 19(6). PMID: 29895784.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic post-conditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 07; 146(2):160-172. PMID: 29570780.
    Citations: 19     Fields:    Translation:AnimalsCells
  43. Maki T, Morancho A, Martinez-San Segundo P, Hayakawa K, Takase H, Liang AC, Gabriel-Salazar M, Medina-Gutiérrez E, Washida K, Montaner J, Lok J, Lo EH, Arai K, Rosell A. Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke. 2018 04; 49(4):1003-1010. PMID: 29511131.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  44. Arai K. Stroke Literature Synopses: Basic Science (2017/Dec). Stroke. 2018 Mar; 49(3):e39-e40. PMID: 29606777.
    Citations:    Fields:    
  45. Lorenzano S, Rost NS, Khan M, Li H, Lima FO, Maas MB, Green RE, Thankachan TK, Dipietro AJ, Arai K, Som AT, Pham LD, Wu O, Harris GJ, Lo EH, Blumberg JB, Milbury PE, Feske SK, Furie KL. Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke. 2018 03; 49(3):630-637. PMID: 29371434.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  46. Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells. 2018 05; 36(5):751-760. PMID: 29314444.
    Citations: 15     Fields:    Translation:AnimalsCells
  47. Takase H, Liang AC, Miyamoto N, Hamanaka G, Ohtomo R, Maki T, Pham LD, Lok J, Lo EH, Arai K. Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress. Neurosci Lett. 2018 03 06; 668:120-125. PMID: 29337010.
    Citations: 7     Fields:    Translation:AnimalsCells
  48. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Dec; 48(12):e336-e337. PMID: 29084814.
    Citations:    Fields:    
  49. Arai K. Stroke Literature Synopses: Basic Science (2017/Aug). Stroke. 2017 Dec; 48(12):e336-e337. PMID: 29520119.
    Citations:    Fields:    
  50. Arai K. Stroke Literature Synopses: Basic Science (2017/May). Stroke. 2017 Aug; 48(8):e193-e194. PMID: 29515270.
    Citations:    Fields:    
  51. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Aug; 48(8):e193-e194. PMID: 28663511.
    Citations:    Fields:    
  52. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 07 15; 26(14):1078-1085. PMID: 28446066.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2018 01; 38(1):75-86. PMID: 28481164.
    Citations: 23     Fields:    Translation:Humans
  54. Arai K. Stroke Literature Synopses: Basic Science (2017/Jan). Stroke. 2017 Mar; 48(3):e85-e86. PMID: 29507448.
  55. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Mar; 48(3):e85-e86. PMID: 28196942.
  56. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211. PMID: 27829126.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  57. Egawa N, Takase H, Josephine L, Takahashi R, Arai K. Clinical application of oligodendrocyte precursor cells for cell-based therapy. Brain Circ. 2016 Jul-Sep; 2(3):121-125. PMID: 30276286.
    Citations: 3     
  58. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 11; 47(11):e250-e251. PMID: 27729580.
  59. Arai K. Stroke Literature Synopses: Basic Science (2016/Sep). Stroke. 2016 Nov; 47(11):e250-e251. PMID: 28163335.
  60. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  61. Fujiwara N, Som AT, Pham LD, Lee BJ, Mandeville ET, Lo EH, Arai K. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 2016 10 28; 633:7-13. PMID: 27589890.
    Citations: 17     Fields:    Translation:AnimalsCells
  62. Egawa N, Lok J, Washida K, Arai K. Mechanisms of Axonal Damage and Repair after Central Nervous System Injury. Transl Stroke Res. 2017 02; 8(1):14-21. PMID: 27566737.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  63. Arai K. Stroke Literature Synopses: Basic Science (2016/May). Stroke. 2016 Jul; 47(7):e187. PMID: 28163337.
  64. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 07; 47(7):e187. PMID: 27283203.
    Citations:    Fields:    
  65. Egawa N, Lok J, Arai K. Mechanisms of cellular plasticity in cerebral perivascular region. Prog Brain Res. 2016; 225:183-200. PMID: 27130416.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  66. Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K. Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke. 2016 Apr; 47(4):1094-100. PMID: 26965847.
    Citations: 43     Fields:    Translation:AnimalsCells
  67. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 03; 47(3):e40-1. PMID: 26846863; PMCID: PMC4766057.
  68. Arai K. Stroke Literature Synopses: Basic Science (2016/January). Stroke. 2016 Mar; 47(3):e40-e41. PMID: 28163336.
  69. Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016; 25(4):705-14. PMID: 26811151.
    Citations: 9     Fields:    Translation:AnimalsCells
  70. Itoh K, Maki T, Shindo A, Egawa N, Liang AC, Itoh N, Lo EH, Lok J, Arai K. Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury. Neurosci Res. 2016 May; 106:66-9. PMID: 26699082.
    Citations: 10     Fields:    Translation:AnimalsCells
  71. Wu L, Ramirez SH, Andrews AM, Leung W, Itoh K, Wu J, Arai K, Lo EH, Lok J. Neuregulin1-ß decreases interleukin-1ß-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016 Jan; 136(2):250-7. PMID: 26438054.
    Citations: 4     Fields:    Translation:HumansCells
  72. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 12; 46(12):e250. PMID: 26534972.
    Citations:    Fields:    Translation:HumansAnimals
  73. Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia D. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222. PMID: 26503597.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  74. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    Citations: 1     Fields:    Translation:Humans
  75. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156.
    Citations: 20     Fields:    Translation:AnimalsCells
  76. Koh SH, Liang AC, Takahashi Y, Maki T, Shindo A, Osumi N, Zhao J, Lin H, Holder JC, Chuang TT, McNeish JD, Arai K, Lo EH. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One. 2015; 10(9):e0138724. PMID: 26407349.
    Citations: 7     Fields:    Translation:AnimalsCells
  77. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 Oct; 46(10):e228. PMID: 26374479.
  78. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4. PMID: 26243221.
    Citations: 19     Fields:    Translation:Animals
  79. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 08; 46(8):e180. PMID: 26138129.
    Citations:    Fields:    
  80. Arai K. Stroke Literature Synopses: Basic Science (2015/June). Stroke. 2015 Aug; 46(8):e180. PMID: 28163334.
  81. Maki T, Takahashi Y, Miyamoto N, Liang AC, Ihara M, Lo EH, Arai K. Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro. Stem Cell Res. 2015 Jul; 15(1):68-74. PMID: 26002630.
    Citations: 13     Fields:    Translation:AnimalsCells
  82. Itoh K, Maki T, Lok J, Arai K. Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke. Brain Res. 2015 Oct 14; 1623:135-49. PMID: 25960351.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  83. Arai K. Stroke literature synopses: basic science. Stroke. 2015 06; 46(6):e133. PMID: 25953364.
    Citations:    Fields:    
  84. Maki T, Maeda M, Uemura M, Lo EK, Terasaki Y, Liang AC, Shindo A, Choi YK, Taguchi A, Matsuyama T, Takahashi R, Ihara M, Arai K. Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter. Neurosci Lett. 2015 Jun 15; 597:164-9. PMID: 25936593.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  85. Arai K. Stroke literature synopses: basic science. Stroke. 2015 Apr; 46(4):e78. PMID: 25744515.
    Citations:    Fields:    
  86. Arai K. Stroke literature synopses: basic science. Stroke. 2015 Feb; 46(2):e29. PMID: 25586830; PMCID: PMC4341918.
  87. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  88. Arai K. Stroke literature synopses: basic science. Stroke. 2014 12; 45(12):e247-8. PMID: 25388425.
    Citations:    Fields:    
  89. Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N, Arai K. p38 MAP kinase mediates transforming-growth factor-ß1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes. Brain Res. 2014 Dec 17; 1593:1-8. PMID: 25451097.
    Citations: 14     Fields:    Translation:HumansCells
  90. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Lee OH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury. Nat Commun. 2014 Sep 17; 5:4952. PMID: 25229625.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  91. Arai K. Stroke literature synopses: basic science. Stroke. 2014 10; 45(10):e201. PMID: 25190437.
    Citations:    Fields:    
  92. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174. PMID: 25078775.
    Citations: 71     Fields:    Translation:AnimalsCells
  93. Arai K. Stroke literature synopses: basic science. Stroke. 2014 Aug; 45(8):e154. PMID: 25005440.
  94. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular ß-amyloid. Ann Clin Transl Neurol. 2014 Aug; 1(8):519-33. PMID: 25356424.
    Citations: 39     Fields:    
  95. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 08; 289(32):21926-36. PMID: 24917672.
    Citations: 11     Fields:    Translation:AnimalsCells
  96. Miyamoto N, Pham LD, Maki T, Liang AC, Arai K. A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion. Neurosci Lett. 2014 Jun 24; 573:40-45. PMID: 24820542.
    Citations: 10     Fields:    Translation:AnimalsCells
  97. Arai K. Stroke literature synopses: basic science. Stroke. 2014 06; 45(6):e97. PMID: 24781078.
    Citations:    Fields:    
  98. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Kim EH, Lee OH, Heo JH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014; 9(4):e94695. PMID: 24760034.
    Citations: 16     Fields:    Translation:Animals
  99. Corbin ZA, Rost NS, Lorenzano S, Kernan WN, Parides MK, Blumberg JB, Milbury PE, Arai K, Hartdegen SN, Lo EH, Feske SK, Furie KL. White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Jul; 23(6):1300-6. PMID: 24439130.
    Citations: 6     Fields:    Translation:Humans
  100. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8. PMID: 24480450.
    Citations: 22     Fields:    Translation:AnimalsCells
  101. Maki T, Liang AC, Miyamoto N, Lo EH, Arai K. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci. 2013 Dec 26; 7:275. PMID: 24421755.
    Citations: 44     
  102. Miyamoto N, Pham LD, Seo JH, Kim KW, Lo EH, Arai K. Crosstalk between cerebral endothelium and oligodendrocyte. Cell Mol Life Sci. 2014 Mar; 71(6):1055-66. PMID: 24132511.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  103. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001.
    Citations: 64     Fields:    Translation:AnimalsCells
  104. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957.
    Citations: 50     Fields:    Translation:AnimalsCells
  105. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847.
    Citations: 49     Fields:    Translation:HumansCells
  106. Le Sage D, Arai K, Glenn DR, DeVience SJ, Pham LM, Rahn-Lee L, Lukin MD, Yacoby A, Komeili A, Walsworth RL. Optical magnetic imaging of living cells. Nature. 2013 Apr 25; 496(7446):486-9. PMID: 23619694.
    Citations: 76     Fields:    Translation:Cells
  107. Belthangady C, Bar-Gill N, Pham LM, Arai K, Le Sage D, Cappellaro P, Walsworth RL. Dressed-state resonant coupling between bright and dark spins in diamond. Phys Rev Lett. 2013 Apr 12; 110(15):157601. PMID: 25167312.
    Citations: 8     Fields:    
  108. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    Citations: 21     Fields:    Translation:AnimalsCells
  109. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937.
    Citations: 7     Fields:    Translation:Animals
  110. Campos F, Qin T, Castillo J, Seo JH, Arai K, Lo EH, Waeber C. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke. 2013 Feb; 44(2):505-11. PMID: 23287783.
    Citations: 49     Fields:    Translation:Animals
  111. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396.
    Citations: 78     Fields:    Translation:AnimalsCells
  112. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8. PMID: 23564100.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  113. Cao J, Guo S, Arai K, Lo EH, Ning M. Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step. Methods Mol Biol. 2013; 1013:227-33. PMID: 23625503.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  114. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80. PMID: 23227954.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  115. Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, Kida K, Van Leyen K, Arai K, Ichinose F. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012 Sep 14; 287(38):32124-35. PMID: 22815476.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  116. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85. PMID: 22712739.
    Citations: 123     Fields:    Translation:HumansCells
  117. Murata Y, Fujiwara N, Seo JH, Yan F, Liu X, Terasaki Y, Luo Y, Arai K, Ji X, Lo EH. Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci. 2012 Jun 13; 32(24):8112-5. PMID: 22699892.
    Citations: 18     Fields:    Translation:AnimalsCells
  118. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  119. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10. PMID: 22529378.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  120. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631.
    Citations: 53     Fields:    Translation:AnimalsCells
  121. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913.
    Citations: 24     Fields:    Translation:AnimalsCells
  122. Chou SH, Lee PS, Konigsberg RG, Gallacci D, Chiou T, Arai K, Simmons S, Bauer D, Feske SK, Lo EH, Ning M. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7. PMID: 21940962.
    Citations: 24     Fields:    Translation:Humans
  123. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609.
    Citations: 62     Fields:    Translation:AnimalsCells
  124. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  125. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51). PMID: 21587157.
    Citations: 12     Fields:    Translation:Animals
  126. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72. PMID: 21415401.
    Citations: 6     Fields:    Translation:Animals
  127. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997.
    Citations: 149     Fields:    Translation:Animals
  128. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15. PMID: 20222144.
    Citations: 37     Fields:    Translation:AnimalsCells
  129. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7. PMID: 20364320.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  130. Arai K, Lo EH. Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res. 2010 Mar; 88(4):758-63. PMID: 19830833.
    Citations: 43     Fields:    Translation:AnimalsCells
  131. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575.
    Citations: 37     Fields:    Translation:AnimalsCells
  132. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687.
    Citations: 49     Fields:    Translation:AnimalsCells
  133. Arai K, Lo EH. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009 Oct 24; 1:6. PMID: 20150984.
    Citations: 32     
  134. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7. PMID: 19840779.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  135. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull. 2009 Oct; 32(10):1639-44. PMID: 19801821.
    Citations: 38     Fields:    Translation:HumansCells
  136. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346.
    Citations: 60     Fields:    Translation:AnimalsCells
  137. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009 Sep; 276(17):4644-52. PMID: 19664070.
    Citations: 119     Fields:    Translation:HumansAnimals
  138. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009 Jul 15; 10:79. PMID: 19604385.
    Citations: 16     Fields:    Translation:Animals
  139. Toma-Hirano M, Namiki S, Shibata Y, Ishida K, Arase H, Miyatake S, Arai K, Kamogawa-Schifter Y. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation. Eur J Immunol. 2009 May; 39(5):1344-52. PMID: 19350550.
    Citations: 4     Fields:    Translation:AnimalsCells
  140. Navaratna D, Guo S, Arai K, Lo EH. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23. PMID: 19363301.
    Citations: 50     Fields:    Translation:Humans
  141. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009 Apr 08; 29(14):4351-5. PMID: 19357263.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  142. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21. PMID: 19319147.
    Citations: 14     Fields:    Translation:HumansAnimals
  143. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic ZS, Lo EH. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43. PMID: 19240740.
    Citations: 28     Fields:    Translation:AnimalsCells
  144. Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5. PMID: 18974377.
    Citations: 32     Fields:    Translation:HumansCells
  145. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404. PMID: 18772448.
    Citations: 45     Fields:    Translation:Animals
  146. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43. PMID: 18635843.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  147. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9. PMID: 17960827.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  148. Toma-Hirano M, Namiki S, Miyatake S, Arai K, Kamogawa-Schifter Y. Type I interferon regulates pDC maturation and Ly49Q expression. Eur J Immunol. 2007 Oct; 37(10):2707-14. PMID: 17823983.
    Citations: 9     Fields:    Translation:AnimalsCells
  149. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8. PMID: 17053180.
    Citations: 96     Fields:    Translation:AnimalsCells
  150. Nakada C, Satoh S, Tabata Y, Arai K, Watanabe S. Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish. Mol Cell Biol. 2006 Oct; 26(19):7246-57. PMID: 16980626.
    Citations: 11     Fields:    Translation:AnimalsCells
  151. Sugiyama D, Ogawa M, Nakao K, Osumi N, Nishikawa S, Nishikawa S, Arai K, Nakahata T, Tsuji K. B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency. Dev Biol. 2007 Jan 01; 301(1):53-61. PMID: 17092496.
    Citations: 6     Fields:    Translation:AnimalsCells
  152. Koso H, Ouchi Y, Tabata Y, Aoki Y, Satoh S, Arai K, Watanabe S. SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway. Dev Biol. 2006 Apr 01; 292(1):265-76. PMID: 16499901.
    Citations: 18     Fields:    Translation:AnimalsCells
  153. Muto A, Arai K, Watanabe S. Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development. Dev Biol. 2006 Apr 01; 292(1):90-102. PMID: 16457799.
    Citations: 16     Fields:    Translation:AnimalsCells
  154. Sugiyama D, Arai K, Tsuji K. Definitive hematopoiesis from acetyl LDL incorporating endothelial cells in the mouse embryo. Stem Cells Dev. 2005 Dec; 14(6):687-96. PMID: 16433624.
    Citations: 6     Fields:    Translation:AnimalsCells
  155. Ouchi Y, Tabata Y, Arai K, Watanabe S. Negative regulation of retinal-neurite extension by beta-catenin signaling pathway. J Cell Sci. 2005 Oct 01; 118(Pt 19):4473-83. PMID: 16179606.
    Citations: 18     Fields:    Translation:AnimalsCells
  156. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9. PMID: 16051896.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  157. Yamashita N, Kim JM, Koiwai O, Arai K, Masai H. Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells. Genes Cells. 2005 Jun; 10(6):551-63. PMID: 15938714.
    Citations: 8     Fields:    Translation:AnimalsCells
  158. Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K, Masai H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem. 2005 Apr 01; 280(13):13062-70. PMID: 15668232.
    Citations: 26     Fields:    Translation:HumansCells
  159. Fujii-Yamamoto H, Kim JM, Arai K, Masai H. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J Biol Chem. 2005 Apr 01; 280(13):12976-87. PMID: 15659392.
    Citations: 46     Fields:    Translation:AnimalsCells
  160. Muto E, Tabata Y, Taneda T, Aoki Y, Muto A, Arai K, Watanabe S. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Biochimie. 2004 Aug; 86(8):523-31. PMID: 15388229.
    Citations: 10     Fields:    Translation:AnimalsCells
  161. Tabata Y, Ouchi Y, Kamiya H, Manabe T, Arai K, Watanabe S. Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Mol Cell Biol. 2004 May; 24(10):4513-21. PMID: 15121868.
    Citations: 23     Fields:    Translation:AnimalsCells
  162. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9. PMID: 15030407.
    Citations: 24     Fields:    Translation:HumansCells
  163. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7. PMID: 12960961.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  164. Arai K, Lee SR, Lo EH. Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003 Sep; 43(3):254-64. PMID: 12898704.
    Citations: 44     Fields:    Translation:AnimalsCells
  165. Furukohri A, Sato N, Masai H, Arai K, Sugino A, Waga S. Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication. J Biochem. 2003 Sep; 134(3):447-57. PMID: 14561731.
    Citations: 11     Fields:    Translation:AnimalsCells
  166. Chen J, Amasaki Y, Kamogawa Y, Nagoya M, Arai N, Arai K, Miyatake S. Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells. J Immunol. 2003 Mar 15; 170(6):3109-17. PMID: 12626567.
    Citations: 9     Fields:    Translation:AnimalsCells
  167. Yasuda Y, Kaneko A, Nishijima I, Miyatake S, Arai K. Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice. Immunology. 2002 Jun; 106(2):212-21. PMID: 12047750.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  168. Yamada M, Sato N, Taniyama C, Ohtani K, Arai K, Masai H. A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. J Biol Chem. 2002 Aug 02; 277(31):27668-81. PMID: 12015319.
    Citations: 14     Fields:    Translation:HumansCells
  169. Zeng R, Aoki Y, Yoshida M, Arai K, Watanabe S. Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. J Immunol. 2002 May 01; 168(9):4567-75. PMID: 11971004.
    Citations: 30     Fields:    Translation:AnimalsCells
  170. Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K, Masai H. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 2002 May 01; 21(9):2168-79. PMID: 11980714.
    Citations: 24     Fields:    Translation:AnimalsCells
  171. Arai K, Lee K, Berthiaume F, Tompkins RG, Yarmush ML. Intrahepatic amino acid and glucose metabolism in a D-galactosamine-induced rat liver failure model. Hepatology. 2001 Aug; 34(2):360-71. PMID: 11481621.
    Citations: 19     Fields:    Translation:Animals
  172. Vercelli D, Jabara HH, Arai K, Yokota T, Geha RS. Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. Eur J Immunol. 1989 Aug; 19(8):1419-24. PMID: 2789139.
    Citations: 43     Fields:    Translation:HumansCells
  173. Vercelli D, Jabara HH, Arai K, Geha RS. Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens. J Exp Med. 1989 Apr 01; 169(4):1295-307. PMID: 2522501.
    Citations: 66     Fields:    Translation:HumansCells
  174. Jabara HH, Ackerman SJ, Vercelli D, Yokota T, Arai K, Abrams J, Dvorak AM, Lavigne MC, Banchereau J, De Vries J, et al. Induction of interleukin-4-dependent IgE synthesis and interleukin-5-dependent eosinophil differentiation by supernatants of a human helper T-cell clone. J Clin Immunol. 1988 Nov; 8(6):437-46. PMID: 2975669.
    Citations: 16     Fields:    Translation:HumansCells
  175. Collins MK, Downward J, Miyajima A, Maruyama K, Arai K, Mulligan RC. Transfer of functional EGF receptors to an IL3-dependent cell line. J Cell Physiol. 1988 Nov; 137(2):293-8. PMID: 3263970.
    Citations: 16     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.