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Last Name

profileKen Arai, Ph.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Radiology, Rm. 2401
149 13th Street
Charlestown MA 02129
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS065089     (ARAI, KEN)Apr 1, 2009 - Jun 30, 2020
Oligo-Vascular Signaling in Stroke
Role: Principal Investigator

P01NS055104     (LO, ENG H.)Jul 1, 2007 - Apr 30, 2019
Remodeling and recovery in the neurovascular unit
Role: Co-Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Esposito E, Hayakawa K, Ahn BJ, Chan SJ, Xing C, Liang AC, Kim KW, Arai K, Lo EH. Effects of ischemic postconditioning on neuronal VEGF regulation and microglial polarization in a rat model of focal cerebral ischemia. J Neurochem. 2018 Mar 23. PMID: 29570780.
    View in: PubMed
  2. Maki T, Morancho A, Martinez-San Segundo P, Hayakawa K, Takase H, Liang AC, Gabriel-Salazar M, Medina-Gutiérrez E, Washida K, Montaner J, Lok J, Lo EH, Arai K, Rosell A. Endothelial Progenitor Cell Secretome and Oligovascular Repair in a Mouse Model of Prolonged Cerebral Hypoperfusion. Stroke. 2018 Apr; 49(4):1003-1010. PMID: 29511131.
    View in: PubMed
  3. Lorenzano S, Rost NS, Khan M, Li H, Lima FO, Maas MB, Green RE, Thankachan TK, Dipietro AJ, Arai K, Som AT, Pham LD, Wu O, Harris GJ, Lo EH, Blumberg JB, Milbury PE, Feske SK, Furie KL. Oxidative Stress Biomarkers of Brain Damage: Hyperacute Plasma F2-Isoprostane Predicts Infarct Growth in Stroke. Stroke. 2018 03; 49(3):630-637. PMID: 29371434.
    View in: PubMed
  4. Takase H, Liang AC, Miyamoto N, Hamanaka G, Ohtomo R, Maki T, Pham LD, Lok J, Lo EH, Arai K. Protective effects of a radical scavenger edaravone on oligodendrocyte precursor cells against oxidative stress. Neurosci Lett. 2018 Mar 06; 668:120-125. PMID: 29337010.
    View in: PubMed
  5. Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells. 2018 Jan 04. PMID: 29314444.
    View in: PubMed
  6. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Dec; 48(12):e336-e337. PMID: 29084814.
    View in: PubMed
  7. Arai K. Stroke Literature Synopses: Basic Science (2017/Aug). Stroke. 2017 Dec; 48(12):e336-e337. PMID: 29520119.
    View in: PubMed
  8. Arai K. Stroke Literature Synopses: Basic Science (2017/May). Stroke. 2017 Aug; 48(8):e193-e194. PMID: 29515270.
    View in: PubMed
  9. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Aug; 48(8):e193-e194. PMID: 28663511.
    View in: PubMed
  10. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 Jul 15; 26(14):1078-1085. PMID: 28446066.
    View in: PubMed
  11. Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2018 Jan; 38(1):75-86. PMID: 28481164.
    View in: PubMed
  12. Arai K. Stroke Literature Synopses: Basic Science (2017/Jan). Stroke. 2017 Mar; 48(3):e85-e86. PMID: 29507448.
    View in: PubMed
  13. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2017 Mar; 48(3):e85-e86. PMID: 28196942.
    View in: PubMed
  14. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2018 03 15; 340:205-211. PMID: 27829126.
    View in: PubMed
  15. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 11; 47(11):e250-e251. PMID: 27729580.
    View in: PubMed
  16. Arai K. Stroke Literature Synopses: Basic Science (2016/Sep). Stroke. 2016 Nov; 47(11):e250-e251. PMID: 28163335.
    View in: PubMed
  17. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    View in: PubMed
  18. Fujiwara N, Som AT, Pham LD, Lee BJ, Mandeville ET, Lo EH, Arai K. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 2016 10 28; 633:7-13. PMID: 27589890.
    View in: PubMed
  19. Egawa N, Lok J, Washida K, Arai K. Mechanisms of Axonal Damage and Repair after Central Nervous System Injury. Transl Stroke Res. 2017 02; 8(1):14-21. PMID: 27566737.
    View in: PubMed
  20. Arai K. Stroke Literature Synopses: Basic Science (2016/May). Stroke. 2016 Jul; 47(7):e187. PMID: 28163337.
    View in: PubMed
  21. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 07; 47(7):e187. PMID: 27283203.
    View in: PubMed
  22. Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K. Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke. 2016 Apr; 47(4):1094-100. PMID: 26965847; PMCID: PMC4811738 [Available on 04/01/17].
  23. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2016 03; 47(3):e40-1. PMID: 26846863; PMCID: PMC4766057 [Available on 03/01/17].
  24. Arai K. Stroke Literature Synopses: Basic Science (2016/January). Stroke. 2016 Mar; 47(3):e40-e41. PMID: 28163336.
    View in: PubMed
  25. Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016; 25(4):705-14. PMID: 26811151.
    View in: PubMed
  26. Itoh K, Maki T, Shindo A, Egawa N, Liang AC, Itoh N, Lo EH, Lok J, Arai K. Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury. Neurosci Res. 2016 May; 106:66-9. PMID: 26699082; PMCID: PMC4846506 [Available on 05/01/17].
  27. Wu L, Ramirez SH, Andrews AM, Leung W, Itoh K, Wu J, Arai K, Lo EH, Lok J. Neuregulin1-ß decreases interleukin-1ß-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016 Jan; 136(2):250-7. PMID: 26438054.
    View in: PubMed
  28. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 12; 46(12):e250. PMID: 26534972; PMCID: PMC4659724 [Available on 12/01/16].
  29. Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia D. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222. PMID: 26503597; PMCID: PMC4622078.
  30. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    View in: PubMed
  31. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156; PMCID: PMC4821018 [Available on 04/01/17].
  32. Koh SH, Liang AC, Takahashi Y, Maki T, Shindo A, Osumi N, Zhao J, Lin H, Holder JC, Chuang TT, McNeish JD, Arai K, Lo EH. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One. 2015; 10(9):e0138724. PMID: 26407349; PMCID: PMC4583469.
  33. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 Oct; 46(10):e228. PMID: 26374479.
    View in: PubMed
  34. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4. PMID: 26243221; PMCID: PMC4604446.
  35. Arai K. Stroke Literature Synopses: Basic Science. Stroke. 2015 08; 46(8):e180. PMID: 26138129; PMCID: PMC4519385 [Available on 08/01/16].
  36. Arai K. Stroke Literature Synopses: Basic Science (2015/June). Stroke. 2015 Aug; 46(8):e180. PMID: 28163334.
    View in: PubMed
  37. Maki T, Takahashi Y, Miyamoto N, Liang AC, Ihara M, Lo EH, Arai K. Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro. Stem Cell Res. 2015 Jul; 15(1):68-74. PMID: 26002630; PMCID: PMC4516627.
  38. Itoh K, Maki T, Lok J, Arai K. Mechanisms of cell-cell interaction in oligodendrogenesis and remyelination after stroke. Brain Res. 2015 Oct 14; 1623:135-49. PMID: 25960351; PMCID: PMC4569526 [Available on 10/14/16].
  39. Arai K. Stroke literature synopses: basic science. Stroke. 2015 06; 46(6):e133. PMID: 25953364; PMCID: PMC4442048 [Available on 06/01/16].
  40. Maki T, Maeda M, Uemura M, Lo EK, Terasaki Y, Liang AC, Shindo A, Choi YK, Taguchi A, Matsuyama T, Takahashi R, Ihara M, Arai K. Potential interactions between pericytes and oligodendrocyte precursor cells in perivascular regions of cerebral white matter. Neurosci Lett. 2015 Jun 15; 597:164-9. PMID: 25936593; PMCID: PMC4443478.
  41. Arai K. Stroke literature synopses: basic science. Stroke. 2015 04; 46(4):e78. PMID: 25744515.
    View in: PubMed
  42. Arai K. Stroke literature synopses: basic science. Stroke. 2015 Feb; 46(2):e29. PMID: 25586830; PMCID: PMC4341918 [Available on 02/01/16].
  43. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    View in: PubMed
  44. Arai K. Stroke literature synopses: basic science. Stroke. 2014 12; 45(12):e247-8. PMID: 25388425; PMCID: PMC4245317 [Available on 12/01/15].
  45. Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N, Arai K. p38 MAP kinase mediates transforming-growth factor-ß1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes. Brain Res. 2014 Dec 17; 1593:1-8. PMID: 25451097.
    View in: PubMed
  46. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Lee OH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury. Nat Commun. 2014 Sep 17; 5:4952. PMID: 25229625; PMCID: PMC4348065.
  47. Arai K. Stroke literature synopses: basic science. Stroke. 2014 10; 45(10):e201. PMID: 25190437; PMCID: PMC4175139 [Available on 10/01/15].
  48. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174. PMID: 25078775; PMCID: PMC4117639.
  49. Arai K. Stroke literature synopses: basic science. Stroke. 2014 Aug; 45(8):e154. PMID: 25005440.
    View in: PubMed
  50. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular ß-amyloid. Ann Clin Transl Neurol. 2014 Aug; 1(8):519-33. PMID: 25356424; PMCID: PMC4184555.
  51. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 08; 289(32):21926-36. PMID: 24917672; PMCID: PMC4139210.
  52. Miyamoto N, Pham LD, Maki T, Liang AC, Arai K. A radical scavenger edaravone inhibits matrix metalloproteinase-9 upregulation and blood-brain barrier breakdown in a mouse model of prolonged cerebral hypoperfusion. Neurosci Lett. 2014 Jun 24; 573:40-45. PMID: 24820542; PMCID: PMC4055517.
  53. Arai K. Stroke literature synopses: basic science. Stroke. 2014 06; 45(6):e97. PMID: 24781078; PMCID: PMC4102631 [Available on 06/01/15].
  54. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Kim EH, Lee OH, Heo JH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014; 9(4):e94695. PMID: 24760034; PMCID: PMC3997571.
  55. Corbin ZA, Rost NS, Lorenzano S, Kernan WN, Parides MK, Blumberg JB, Milbury PE, Arai K, Hartdegen SN, Lo EH, Feske SK, Furie KL. White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Jul; 23(6):1300-6. PMID: 24439130; PMCID: PMC4058345.
  56. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8. PMID: 24480450; PMCID: PMC3966549.
  57. Maki T, Liang AC, Miyamoto N, Lo EH, Arai K. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci. 2013 Dec 26; 7:275. PMID: 24421755; PMCID: PMC3872787.
  58. Miyamoto N, Pham LD, Seo JH, Kim KW, Lo EH, Arai K. Crosstalk between cerebral endothelium and oligodendrocyte. Cell Mol Life Sci. 2014 Mar; 71(6):1055-66. PMID: 24132511; PMCID: PMC3944198.
  59. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001; PMCID: PMC3985753.
  60. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957; PMCID: PMC3818687.
  61. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847; PMCID: PMC3845030.
  62. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    View in: PubMed
  63. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937; PMCID: PMC3568130.
  64. Campos F, Qin T, Castillo J, Seo JH, Arai K, Lo EH, Waeber C. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke. 2013 Feb; 44(2):505-11. PMID: 23287783; PMCID: PMC3586809.
  65. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396; PMCID: PMC3561802.
  66. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8. PMID: 23564100; PMCID: PMC3985720.
  67. Cao J, Guo S, Arai K, Lo EH, Ning M. Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step. Methods Mol Biol. 2013; 1013:227-33. PMID: 23625503; PMCID: PMC3985769.
  68. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80. PMID: 23227954; PMCID: PMC3604050.
  69. Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, Kida K, Van Leyen K, Arai K, Ichinose F. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012 Sep 14; 287(38):32124-35. PMID: 22815476; PMCID: PMC3442543.
  70. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85. PMID: 22712739; PMCID: PMC3985770.
  71. Murata Y, Fujiwara N, Seo JH, Yan F, Liu X, Terasaki Y, Luo Y, Arai K, Ji X, Lo EH. Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci. 2012 Jun 13; 32(24):8112-5. PMID: 22699892; PMCID: PMC3752060.
  72. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075; PMCID: PMC3985722.
  73. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10. PMID: 22529378; PMCID: PMC3358881.
  74. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631; PMCID: PMC3325331.
  75. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913; PMCID: PMC3302953.
  76. Chou SH, Lee PS, Konigsberg RG, Gallacci D, Chiou T, Arai K, Simmons S, Bauer D, Feske SK, Lo EH, Ning M. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7. PMID: 21940962; PMCID: PMC3537515.
  77. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609; PMCID: PMC3145205.
  78. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695; PMCID: PMC3530192.
  79. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51). PMID: 21587157; PMCID: PMC3197095.
  80. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72. PMID: 21415401.
    View in: PubMed
  81. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997; PMCID: PMC2932799.
  82. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15. PMID: 20222144; PMCID: PMC3814180.
  83. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7. PMID: 20364320; PMCID: PMC3985723.
  84. Arai K, Lo EH. Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res. 2010 Mar; 88(4):758-63. PMID: 19830833; PMCID: PMC3705578.
  85. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575; PMCID: PMC2915762.
  86. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687; PMCID: PMC2822804.
  87. Arai K, Lo EH. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009 Oct 24; 1:6. PMID: 20150984; PMCID: PMC2820444.
  88. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7. PMID: 19840779; PMCID: PMC2797401.
  89. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull. 2009 Oct; 32(10):1639-44. PMID: 19801821; PMCID: PMC3691964.
  90. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346; PMCID: PMC2773137.
  91. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009 Sep; 276(17):4644-52. PMID: 19664070; PMCID: PMC3712842.
  92. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009 Jul 15; 10:79. PMID: 19604385; PMCID: PMC2714858.
  93. Navaratna D, Guo S, Arai K, Lo EH. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23. PMID: 19363301; PMCID: PMC2679890.
  94. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009 Apr 08; 29(14):4351-5. PMID: 19357263; PMCID: PMC3849498.
  95. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21. PMID: 19319147; PMCID: PMC3691988.
  96. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic ZS, Lo EH. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43. PMID: 19240740; PMCID: PMC3712840.
  97. Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5. PMID: 18974377; PMCID: PMC3691992.
  98. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404. PMID: 18772448; PMCID: PMC3712841.
  99. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43. PMID: 18635843; PMCID: PMC2754072.
  100. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9. PMID: 17960827; PMCID: PMC2759176.
  101. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8. PMID: 17053180.
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  102. Nakada C, Satoh S, Tabata Y, Arai K, Watanabe S. Transcriptional repressor foxl1 regulates central nervous system development by suppressing shh expression in zebra fish. Mol Cell Biol. 2006 Oct; 26(19):7246-57. PMID: 16980626; PMCID: PMC1592895.
  103. Sugiyama D, Ogawa M, Nakao K, Osumi N, Nishikawa S, Nishikawa S, Arai K, Nakahata T, Tsuji K. B cell potential can be obtained from pre-circulatory yolk sac, but with low frequency. Dev Biol. 2007 Jan 01; 301(1):53-61. PMID: 17092496.
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  104. Koso H, Ouchi Y, Tabata Y, Aoki Y, Satoh S, Arai K, Watanabe S. SSEA-1 marks regionally restricted immature subpopulations of embryonic retinal progenitor cells that are regulated by the Wnt signaling pathway. Dev Biol. 2006 Apr 01; 292(1):265-76. PMID: 16499901.
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  105. Muto A, Arai K, Watanabe S. Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development. Dev Biol. 2006 Apr 01; 292(1):90-102. PMID: 16457799.
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  106. Sugiyama D, Arai K, Tsuji K. Definitive hematopoiesis from acetyl LDL incorporating endothelial cells in the mouse embryo. Stem Cells Dev. 2005 Dec; 14(6):687-96. PMID: 16433624.
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  107. Ouchi Y, Tabata Y, Arai K, Watanabe S. Negative regulation of retinal-neurite extension by beta-catenin signaling pathway. J Cell Sci. 2005 Oct 01; 118(Pt 19):4473-83. PMID: 16179606.
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  108. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9. PMID: 16051896.
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  109. Yamashita N, Kim JM, Koiwai O, Arai K, Masai H. Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells. Genes Cells. 2005 Jun; 10(6):551-63. PMID: 15938714.
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  110. Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K, Masai H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. J Biol Chem. 2005 Apr 01; 280(13):13062-70. PMID: 15668232.
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  111. Fujii-Yamamoto H, Kim JM, Arai K, Masai H. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J Biol Chem. 2005 Apr 01; 280(13):12976-87. PMID: 15659392.
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  112. Muto E, Tabata Y, Taneda T, Aoki Y, Muto A, Arai K, Watanabe S. Identification and characterization of Veph, a novel gene encoding a PH domain-containing protein expressed in the developing central nervous system of vertebrates. Biochimie. 2004 Aug; 86(8):523-31. PMID: 15388229.
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  113. Tabata Y, Ouchi Y, Kamiya H, Manabe T, Arai K, Watanabe S. Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Mol Cell Biol. 2004 May; 24(10):4513-21. PMID: 15121868; PMCID: PMC400481.
  114. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9. PMID: 15030407.
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  115. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7. PMID: 12960961.
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  116. Arai K, Lee SR, Lo EH. Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003 Sep; 43(3):254-64. PMID: 12898704.
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  117. Furukohri A, Sato N, Masai H, Arai K, Sugino A, Waga S. Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication. J Biochem. 2003 Sep; 134(3):447-57. PMID: 14561731.
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  118. Chen J, Amasaki Y, Kamogawa Y, Nagoya M, Arai N, Arai K, Miyatake S. Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells. J Immunol. 2003 Mar 15; 170(6):3109-17. PMID: 12626567.
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  119. Yasuda Y, Kaneko A, Nishijima I, Miyatake S, Arai K. Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice. Immunology. 2002 Jun; 106(2):212-21. PMID: 12047750; PMCID: PMC1782720.
  120. Zeng R, Aoki Y, Yoshida M, Arai K, Watanabe S. Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. J Immunol. 2002 May 01; 168(9):4567-75. PMID: 11971004.
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  121. Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K, Masai H. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. EMBO J. 2002 May 01; 21(9):2168-79. PMID: 11980714; PMCID: PMC125997.
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