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Otto Rapalino, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sreedher G, Ho ML, Smith M, Udayasankar UK, Risacher S, Rapalino O, Greer MC, Doria AS, Gee MS. Magnetic resonance imaging quality control, quality assurance and quality improvement. Pediatr Radiol. 2021 May; 51(5):698-708. PMID: 33772641.
    Citations: 1     Fields:    
  2. Douglas VP, Douglas KAA, Rapalino O, Champion SN, Chwalisz BK. Nelson Syndrome: Clival Invasion of Corticotroph Pituitary Adenoma Resulting in Alternating Sixth Nerve Palsies. J Neuroophthalmol. 2021 Mar 01; 41(1):114-118. PMID: 33394640.
    Citations:    Fields:    
  3. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. J Neurol Sci. 2021 02 15; 421:117308. PMID: 33497950.
    Citations: 3     Fields:    Translation:Humans
  4. Rapalino O, Pourvaziri A, Maher M, Jaramillo-Cardoso A, Edlow BL, Conklin J, Huang S, Westover B, Romero JM, Halpern E, Gupta R, Pomerantz S, Schaefer P, Gonzalez RG, Mukerji SS, Lev MH. Clinical, Imaging, and Lab Correlates of Severe COVID-19 Leukoencephalopathy. AJNR Am J Neuroradiol. 2021 Jan 07. PMID: 33414226.
    Citations: 1     Fields:    
  5. Price BH, Perez DL, Rapalino O, Oakley DH. Case 41-2020: A 62-Year-Old Man with Memory Loss and Odd Behavior. N Engl J Med. 2020 Dec 31; 383(27):2666-2675. PMID: 33382934.
    Citations:    Fields:    Translation:Humans
  6. Caplan DN, Rapalino O, Karaa A, Rosovsky RP, Uljon S. Case 35-2020: A 59-Year-Old Woman with Type 1 Diabetes Mellitus and Obtundation. N Engl J Med. 2020 Nov 12; 383(20):1974-1983. PMID: 33176089.
    Citations:    Fields:    Translation:Humans
  7. Rapalino O, Weerasekera A, Moum SJ, Eikermann-Haerter K, Edlow BL, Fischer D, Torrado-Carvajal A, Loggia ML, Mukerji SS, Schaefer PW, Gonzalez RG, Lev MH, Ratai EM. Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations. AJNR Am J Neuroradiol. 2021 01; 42(1):37-41. PMID: 33122208.
    Citations:    Fields:    Translation:Humans
  8. Goncalves Filho ALM, Conklin J, Longo MGF, Cauley SF, Polak D, Liu W, Splitthoff DN, Lo WC, Kirsch JE, Setsompop K, Schaefer PW, Huang SY, Rapalino O. Accelerated Post-contrast Wave-CAIPI T1 SPACE Achieves Equivalent Diagnostic Performance Compared With Standard T1 SPACE for the Detection of Brain Metastases in Clinical 3T MRI. Front Neurol. 2020; 11:587327. PMID: 33193054.
    Citations:    
  9. Fischer D, Threlkeld ZD, Bodien YG, Kirsch JE, Huang SY, Schaefer PW, Rapalino O, Hochberg LR, Rosen BR, Edlow BL. Intact Brain Network Function in an Unresponsive Patient with COVID-19. Ann Neurol. 2020 10; 88(4):851-854. PMID: 32613682.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  10. Longo MGF, Conklin J, Cauley SF, Setsompop K, Tian Q, Polak D, Polackal M, Splitthoff D, Liu W, González RG, Schaefer PW, Kirsch JE, Rapalino O, Huang SY. Evaluation of Ultrafast Wave-CAIPI MPRAGE for Visual Grading and Automated Measurement of Brain Tissue Volume. AJNR Am J Neuroradiol. 2020 08; 41(8):1388-1396. PMID: 32732274.
    Citations: 1     Fields:    Translation:Humans
  11. Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux J, Sabeti P, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Cerebral Microvascular Injury in Severe COVID-19. medRxiv. 2020 Jul 24. PMID: 32743599.
    Citations:    
  12. Schweitzer JS, Song B, Herrington TM, Park TY, Lee N, Ko S, Jeon J, Cha Y, Kim K, Li Q, Henchcliffe C, Kaplitt M, Neff C, Rapalino O, Seo H, Lee IH, Kim J, Kim T, Petsko GA, Ritz J, Cohen BM, Kong SW, Leblanc P, Carter BS, Kim KS. Personalized iPSC-Derived Dopamine Progenitor Cells for Parkinson's Disease. N Engl J Med. 2020 05 14; 382(20):1926-1932. PMID: 32402162.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  13. Berns JS, Rapalino O, Fenves AZ, El Khoury JB, Klepeis VE, Anahtar MN. Case 11-2020: A 37-Year-Old Man with Facial Droop, Dysarthria, and Kidney Failure. N Engl J Med. 2020 Apr 09; 382(15):1457-1466. PMID: 32268031.
    Citations: 1     Fields:    Translation:Humans
  14. Rapalino O. A Direct Window into Brain Cancer Metabolism by Using MRI. Radiology. 2020 04; 295(1):190-191. PMID: 32073381.
    Citations:    Fields:    Translation:Humans
  15. Due-Tønnessen P, Pinho MC, Emblem KE, Hald JK, Kanoto M, Abildgaard A, Sederevicius D, Groote IR, Rapalino O, Bjørnerud A. The Impact of MRI Features and Observer Confidence on the Treatment Decision-Making for Patients with Untreated Glioma. Sci Rep. 2019 12 27; 9(1):19898. PMID: 31882644.
    Citations:    Fields:    Translation:Humans
  16. Conklin J, Longo MGF, Cauley SF, Setsompop K, González RG, Schaefer PW, Kirsch JE, Rapalino O, Huang SY. Validation of Highly Accelerated Wave-CAIPI SWI Compared with Conventional SWI and T2*-Weighted Gradient Recalled-Echo for Routine Clinical Brain MRI at 3T. AJNR Am J Neuroradiol. 2019 12; 40(12):2073-2080. PMID: 31727749.
    Citations: 3     Fields:    Translation:Humans
  17. Chang K, Beers AL, Bai HX, Brown JM, Ly KI, Li X, Senders JT, Kavouridis VK, Boaro A, Su C, Bi WL, Rapalino O, Liao W, Shen Q, Zhou H, Xiao B, Wang Y, Zhang PJ, Pinho MC, Wen PY, Batchelor TT, Boxerman JL, Arnaout O, Rosen BR, Gerstner ER, Yang L, Huang RY, Kalpathy-Cramer J. Automatic assessment of glioma burden: a deep learning algorithm for fully automated volumetric and bidimensional measurement. Neuro Oncol. 2019 11 04; 21(11):1412-1422. PMID: 31190077.
    Citations: 17     Fields:    Translation:Humans
  18. Bale TA, Jordan JT, Rapalino O, Ramamurthy N, Jessop N, DeWitt JC, Nardi V, Alvarez MM, Frosch M, Batchelor TT, Louis DN, Iafrate AJ, Cahill DP, Lennerz JK. Financially effective test algorithm to identify an aggressive, EGFR-amplified variant of IDH-wildtype, lower-grade diffuse glioma. Neuro Oncol. 2019 05 06; 21(5):596-605. PMID: 30496526.
    Citations: 5     Fields:    Translation:Humans
  19. Wang Y, Rapalino O, Heidari P, Loeffler J, Shih HA, Oh K, Mahmood U. C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease and Response to Chemoradiation Therapy. Int J Radiat Oncol Biol Phys. 2018 11 15; 102(4):1024-1028. PMID: 29913253.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  20. Eichler FS, Swoboda KJ, Hunt AL, Cestari DM, Rapalino O. Case 38-2017. A 20-Year-Old Woman with Seizures and Progressive Dystonia. N Engl J Med. 2017 Dec 14; 377(24):2376-2385. PMID: 29236641.
    Citations: 2     Fields:    Translation:Humans
  21. Fagundes J, Longo MG, Huang SY, Rosen BR, Witzel T, Heberlein K, Gonzalez RG, Schaefer P, Rapalino O. Diagnostic Performance of a 10-Minute Gadolinium-Enhanced Brain MRI Protocol Compared with the Standard Clinical Protocol for Detection of Intracranial Enhancing Lesions. AJNR Am J Neuroradiol. 2017 Sep; 38(9):1689-1694. PMID: 28705816.
    Citations: 2     Fields:    Translation:Humans
  22. Rapalino O, Mullins ME. Intracranial Infectious and Inflammatory Diseases Presenting as Neurosurgical Pathologies. Neurosurgery. 2017 Jul 01; 81(1):10-28. PMID: 28575459.
    Citations: 3     Fields:    Translation:Humans
  23. Longo MG, Fagundes J, Huang S, Mehan W, Witzel T, Bhat H, Heberlein K, Rosen BR, Rosenthal D, Gonzalez RG, Schaefer PW, Rapalino O. Simultaneous Multislice-Based 5-Minute Lumbar Spine MRI Protocol: Initial Experience in a Clinical Setting. J Neuroimaging. 2017 09; 27(5):442-446. PMID: 28574665.
    Citations: 2     Fields:    Translation:Humans
  24. MacDonald SM, Rapalino O, Sherry NA, Cohen AB, Ebb DH, Tarbell NJ, Oakley DH. Case 32-2016. A 20-Year-Old Man with Gynecomastia. N Engl J Med. 2016 10 20; 375(16):1567-1579. PMID: 27797319.
    Citations:    Fields:    Translation:Humans
  25. Byrne TN, Stone JH, Pillai SS, Rapalino O, Deshpande V. Case Records of the Massachusetts General Hospital. Case 31-2016. A 53-Year-Old Man with Diplopia, Polydipsia, and Polyuria. N Engl J Med. 2016 10 13; 375(15):1469-1480. PMID: 27732818.
    Citations: 3     Fields:    Translation:Humans
  26. Rapalino O, Ratai EM. Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy. Magn Reson Imaging Clin N Am. 2016 Nov; 24(4):671-686. PMID: 27742109.
    Citations: 6     Fields:    Translation:Humans
  27. Jafari-Khouzani K, Loebel F, Bogner W, Rapalino O, Gonzalez GR, Gerstner E, Chi AS, Batchelor TT, Rosen BR, Unkelbach J, Shih HA, Cahill DP, Andronesi OC. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients. Neuro Oncol. 2016 11; 18(11):1569-1578. PMID: 27382115.
    Citations: 15     Fields:    Translation:Humans
  28. Prakkamakul S, Witzel T, Huang S, Boulter D, Borja MJ, Schaefer P, Rosen B, Heberlein K, Ratai E, Gonzalez G, Rapalino O. Ultrafast Brain MRI: Clinical Deployment and Comparison to Conventional Brain MRI at 3T. J Neuroimaging. 2016 09; 26(5):503-10. PMID: 27273370.
    Citations: 7     Fields:    Translation:Humans
  29. Prakkamakul S, Schaefer P, Gonzalez G, Rapalino O. MRI Patterns of Isolated Lesions in the Medulla Oblongata. J Neuroimaging. 2017 01; 27(1):135-143. PMID: 27221582.
    Citations: 1     Fields:    Translation:Humans
  30. Rapalino O, Batchelor T, González RG. Intra-axial brain tumors. Handb Clin Neurol. 2016; 135:253-274. PMID: 27432670.
    Citations: 1     Fields:    Translation:Humans
  31. Copen WA, Lev MH, Rapalino O. Brain perfusion: computed tomography and magnetic resonance techniques. Handb Clin Neurol. 2016; 135:117-135. PMID: 27432662.
    Citations: 4     Fields:    Translation:Humans
  32. Rapalino O, Smirniotopoulos JG. Extra-axial brain tumors. Handb Clin Neurol. 2016; 135:275-291. PMID: 27432671.
    Citations: 2     Fields:    Translation:Humans
  33. Giantsoudi D, Sethi RV, Yeap BY, Eaton BR, Ebb DH, Caruso PA, Rapalino O, Chen YE, Adams JA, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):287-296. PMID: 26691786.
    Citations: 23     Fields:    Translation:HumansCellsPHPublic Health
  34. Batchelor TT, Chen YB, Rapalino O, Cobos I. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 23-2015. A 51-Year-Old Woman with Headache, Cognitive Impairment, and Weakness. N Engl J Med. 2015 Jul 23; 373(4):367-77. PMID: 26200983.
    Citations:    Fields:    Translation:Humans
  35. Emblem KE, Pinho MC, Zöllner FG, Due-Tonnessen P, Hald JK, Schad LR, Meling TR, Rapalino O, Bjornerud A. A generic support vector machine model for preoperative glioma survival associations. Radiology. 2015 Apr; 275(1):228-34. PMID: 25486589.
    Citations: 24     Fields:    Translation:Humans
  36. Mehan WA, González RG, Buchbinder BR, Chen JW, Copen WA, Gupta R, Hirsch JA, Hunter GJ, Hunter S, Johnson JM, Kelly HR, Larvie M, Lev MH, Pomerantz SR, Rapalino O, Rincon S, Romero JM, Schaefer PW, Shah V. Optimal brain MRI protocol for new neurological complaint. PLoS One. 2014; 9(10):e110803. PMID: 25343371.
    Citations: 3     Fields:    Translation:Humans
  37. Krishnamoorthy KS, Eichler F, Rapalino O, Frosch MP. Case records of the Massachusetts General Hospital. Case 14-2014. An 11-month-old girl with developmental delay. N Engl J Med. 2014 May 08; 370(19):1830-41. PMID: 24806163.
    Citations:    Fields:    Translation:Humans
  38. Sethi RV, Giantsoudi D, Raiford M, Malhi I, Niemierko A, Rapalino O, Caruso P, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):655-63. PMID: 24521681.
    Citations: 19     Fields:    Translation:HumansCells
  39. Reuter M, Gerstner ER, Rapalino O, Batchelor TT, Rosen B, Fischl B. Impact of MRI head placement on glioma response assessment. J Neurooncol. 2014 May; 118(1):123-9. PMID: 24566765.
    Citations: 14     Fields:    Translation:Humans
  40. Eichner C, Jafari-Khouzani K, Cauley S, Bhat H, Polaskova P, Andronesi OC, Rapalino O, Turner R, Wald LL, Stufflebeam S, Setsompop K. Slice accelerated gradient-echo spin-echo dynamic susceptibility contrast imaging with blipped CAIPI for increased slice coverage. Magn Reson Med. 2014 Sep; 72(3):770-8. PMID: 24285593.
    Citations: 16     Fields:    Translation:Humans
  41. Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013 Sep; 123(9):3659-63. PMID: 23999439.
    Citations: 59     Fields:    Translation:Humans
  42. Caruso PA, Johnson J, Thibert R, Rapalino O, Rincon S, Ratai EM. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimaging Clin N Am. 2013 Aug; 23(3):407-24. PMID: 23928197.
    Citations: 2     Fields:    Translation:Humans
  43. González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R. The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg. 2013 May; 5 Suppl 1:i7-12. PMID: 23493340.
    Citations: 22     Fields:    Translation:Humans
  44. Pomerantz SR, Kamalian S, Zhang D, Gupta R, Rapalino O, Sahani DV, Lev MH. Virtual monochromatic reconstruction of dual-energy unenhanced head CT at 65-75 keV maximizes image quality compared with conventional polychromatic CT. Radiology. 2013 Jan; 266(1):318-25. PMID: 23074259.
    Citations: 34     Fields:    Translation:Humans
  45. Musolino PL, Rapalino O, Caruso P, Caviness VS, Eichler FS. Hypoperfusion predicts lesion progression in cerebral X-linked adrenoleukodystrophy. Brain. 2012 Sep; 135(Pt 9):2676-83. PMID: 22961546.
    Citations: 16     Fields:    Translation:HumansCells
  46. Rapalino O, Kamalian S, Kamalian S, Payabvash S, Souza LC, Zhang D, Mukta J, Sahani DV, Lev MH, Pomerantz SR. Cranial CT with adaptive statistical iterative reconstruction: improved image quality with concomitant radiation dose reduction. AJNR Am J Neuroradiol. 2012 Apr; 33(4):609-15. PMID: 22207302.
    Citations: 36     Fields:    Translation:Humans
  47. Fearing MK, Israel EJ, Sahai I, Rapalino O, Lisovsky M. Case records of the Massachusetts General Hospital. Case 12-2011. A 9-month-old boy with acute liver failure. N Engl J Med. 2011 Apr 21; 364(16):1545-56. PMID: 21506744.
    Citations: 4     Fields:    Translation:Humans
  48. Jensen JH, Falangola MF, Hu C, Tabesh A, Rapalino O, Lo C, Helpern JA. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed. 2011 Jun; 24(5):452-7. PMID: 20960579.
    Citations: 63     Fields:    Translation:Humans
  49. Greenberg SM, Rapalino O, Frosch MP. Case records of the Massachusetts General Hospital. Case 22-2010. An 87-year-old woman with dementia and a seizure. N Engl J Med. 2010 Jul 22; 363(4):373-81. PMID: 20660406.
    Citations: 4     Fields:    Translation:Humans
  50. Rapalino O. Thalamic anisotropy and functional disability. AJNR Am J Neuroradiol. 2009 Aug; 30(7):1387. PMID: 19509070.
    Citations: 1     Fields:    Translation:HumansCells
  51. Lin K, Rapalino O, Lee B, Do KG, Sussmann AR, Law M, Pramanik BK. Correlation of volumetric mismatch and mismatch of Alberta Stroke Program Early CT Scores on CT perfusion maps. Neuroradiology. 2009 Jan; 51(1):17-23. PMID: 18787815.
    Citations: 15     Fields:    Translation:Humans
  52. Lu H, Law M, Ge Y, Hesseltine SM, Rapalino O, Jensen JH, Helpern JA. Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR Biomed. 2008 Mar; 21(3):226-32. PMID: 17557363.
    Citations: 4     Fields:    Translation:Humans
  53. Rapalino OA, Levine DN. Developmental apraxia arising from neonatal brachial plexus palsy. Neurology. 2000 Dec 12; 55(11):1761. PMID: 11113250.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.