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Otto Rapalino, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bale TA, Jordan JT, Rapalino O, Ramamurthy N, Jessop N, DeWitt JC, Nardi V, Martinez-Lage Alvarez M, Frosch M, Batchelor TT, Louis DN, Iafrate AJ, Cahill DP, Lennerz JK. Financially Effective Test-Algorithm to Identify an Aggressive, EGFR-amplified Variant of IDH-Wildtype, Lower-Grade Diffuse Glioma. Neuro Oncol. 2018 Nov 28. PMID: 30496526.
    Citations:    Fields:    
  2. Wang Y, Rapalino O, Heidari P, Loeffler J, Shih HA, Oh K, Mahmood U. C11 Methionine PET (MET-PET) Imaging of Glioblastoma for Detecting Postoperative Residual Disease and Response to Chemoradiation Therapy. Int J Radiat Oncol Biol Phys. 2018 Nov 15; 102(4):1024-1028. PMID: 29913253.
    Citations:    Fields:    
  3. Eichler FS, Swoboda KJ, Hunt AL, Cestari DM, Rapalino O. Case 38-2017. A 20-Year-Old Woman with Seizures and Progressive Dystonia. N Engl J Med. 2017 Dec 14; 377(24):2376-2385. PMID: 29236641.
    Citations:    Fields:    Translation:Humans
  4. Fagundes J, Longo MG, Huang SY, Rosen BR, Witzel T, Heberlein K, Gonzalez RG, Schaefer P, Rapalino O. Diagnostic Performance of a 10-Minute Gadolinium-Enhanced Brain MRI Protocol Compared with the Standard Clinical Protocol for Detection of Intracranial Enhancing Lesions. AJNR Am J Neuroradiol. 2017 Sep; 38(9):1689-1694. PMID: 28705816.
    Citations:    Fields:    Translation:Humans
  5. Rapalino O, Mullins ME. Intracranial Infectious and Inflammatory Diseases Presenting as Neurosurgical Pathologies. Neurosurgery. 2017 Jul 01; 81(1):10-28. PMID: 28575459.
    Citations:    Fields:    Translation:Humans
  6. Longo MG, Fagundes J, Huang S, Mehan W, Witzel T, Bhat H, Heberlein K, Rosen BR, Rosenthal D, Gonzalez RG, Schaefer PW, Rapalino O. Simultaneous Multislice-Based 5-Minute Lumbar Spine MRI Protocol: Initial Experience in a Clinical Setting. J Neuroimaging. 2017 09; 27(5):442-446. PMID: 28574665.
    Citations:    Fields:    Translation:Humans
  7. MacDonald SM, Rapalino O, Sherry NA, Cohen AB, Ebb DH, Tarbell NJ, Oakley DH. Case 32-2016. A 20-Year-Old Man with Gynecomastia. N Engl J Med. 2016 10 20; 375(16):1567-1579. PMID: 27797319.
    Citations:    Fields:    Translation:Humans
  8. Byrne TN, Stone JH, Pillai SS, Rapalino O, Deshpande V. Case Records of the Massachusetts General Hospital. Case 31-2016. A 53-Year-Old Man with Diplopia, Polydipsia, and Polyuria. N Engl J Med. 2016 10 13; 375(15):1469-1480. PMID: 27732818.
    Citations: 1     Fields:    Translation:Humans
  9. Rapalino O, Ratai EM. Multiparametric Imaging Analysis: Magnetic Resonance Spectroscopy. Magn Reson Imaging Clin N Am. 2016 Nov; 24(4):671-686. PMID: 27742109.
    Citations: 3     Fields:    Translation:Humans
  10. Jafari-Khouzani K, Loebel F, Bogner W, Rapalino O, Gonzalez GR, Gerstner E, Chi AS, Batchelor TT, Rosen BR, Unkelbach J, Shih HA, Cahill DP, Andronesi OC. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients. Neuro Oncol. 2016 11; 18(11):1569-1578. PMID: 27382115.
    Citations: 5     Fields:    Translation:Humans
  11. Prakkamakul S, Witzel T, Huang S, Boulter D, Borja MJ, Schaefer P, Rosen B, Heberlein K, Ratai E, Gonzalez G, Rapalino O. Ultrafast Brain MRI: Clinical Deployment and Comparison to Conventional Brain MRI at 3T. J Neuroimaging. 2016 09; 26(5):503-10. PMID: 27273370.
    Citations:    Fields:    Translation:Humans
  12. Prakkamakul S, Schaefer P, Gonzalez G, Rapalino O. MRI Patterns of Isolated Lesions in the Medulla Oblongata. J Neuroimaging. 2017 01; 27(1):135-143. PMID: 27221582.
    Citations: 1     Fields:    Translation:Humans
  13. Rapalino O, Batchelor T, González RG. Intra-axial brain tumors. Handb Clin Neurol. 2016; 135:253-274. PMID: 27432670.
    Citations:    Fields:    Translation:Humans
  14. Copen WA, Lev MH, Rapalino O. Brain perfusion: computed tomography and magnetic resonance techniques. Handb Clin Neurol. 2016; 135:117-135. PMID: 27432662.
    Citations: 1     Fields:    Translation:Humans
  15. Rapalino O, Smirniotopoulos JG. Extra-axial brain tumors. Handb Clin Neurol. 2016; 135:275-291. PMID: 27432671.
    Citations: 1     Fields:    Translation:Humans
  16. Giantsoudi D, Sethi RV, Yeap BY, Eaton BR, Ebb DH, Caruso PA, Rapalino O, Chen YL, Adams JA, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Incidence of CNS Injury for a Cohort of 111 Patients Treated With Proton Therapy for Medulloblastoma: LET and RBE Associations for Areas of Injury. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):287-96. PMID: 26691786.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  17. Batchelor TT, Chen YB, Rapalino O, Cobos I. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 23-2015. A 51-Year-Old Woman with Headache, Cognitive Impairment, and Weakness. N Engl J Med. 2015 Jul 23; 373(4):367-77. PMID: 26200983.
    Citations:    Fields:    Translation:Humans
  18. Emblem KE, Pinho MC, Zöllner FG, Due-Tonnessen P, Hald JK, Schad LR, Meling TR, Rapalino O, Bjornerud A. A generic support vector machine model for preoperative glioma survival associations. Radiology. 2015 Apr; 275(1):228-34. PMID: 25486589.
    Citations: 6     Fields:    Translation:Humans
  19. Mehan WA, González RG, Buchbinder BR, Chen JW, Copen WA, Gupta R, Hirsch JA, Hunter GJ, Hunter S, Johnson JM, Kelly HR, Larvie M, Lev MH, Pomerantz SR, Rapalino O, Rincon S, Romero JM, Schaefer PW, Shah V. Optimal brain MRI protocol for new neurological complaint. PLoS One. 2014; 9(10):e110803. PMID: 25343371; PMCID: PMC4208779.
    Citations:    Fields:    Translation:Humans
  20. Krishnamoorthy KS, Eichler F, Rapalino O, Frosch MP. Case records of the Massachusetts General Hospital. Case 14-2014. An 11-month-old girl with developmental delay. N Engl J Med. 2014 May 08; 370(19):1830-41. PMID: 24806163.
    Citations:    Fields:    Translation:Humans
  21. Sethi RV, Giantsoudi D, Raiford M, Malhi I, Niemierko A, Rapalino O, Caruso P, Yock TI, Tarbell NJ, Paganetti H, MacDonald SM. Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses. Int J Radiat Oncol Biol Phys. 2014 Mar 01; 88(3):655-63. PMID: 24521681.
    Citations: 15     Fields:    Translation:HumansCells
  22. Reuter M, Gerstner ER, Rapalino O, Batchelor TT, Rosen B, Fischl B. Impact of MRI head placement on glioma response assessment. J Neurooncol. 2014 May; 118(1):123-9. PMID: 24566765; PMCID: PMC4026260.
    Citations: 12     Fields:    Translation:Humans
  23. Eichner C, Jafari-Khouzani K, Cauley S, Bhat H, Polaskova P, Andronesi OC, Rapalino O, Turner R, Wald LL, Stufflebeam S, Setsompop K. Slice accelerated gradient-echo spin-echo dynamic susceptibility contrast imaging with blipped CAIPI for increased slice coverage. Magn Reson Med. 2014 Sep; 72(3):770-8. PMID: 24285593; PMCID: PMC4002660.
    Citations: 11     Fields:    Translation:Humans
  24. Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013 Sep; 123(9):3659-63. PMID: 23999439; PMCID: PMC3754248.
    Citations: 39     Fields:    Translation:Humans
  25. Caruso PA, Johnson J, Thibert R, Rapalino O, Rincon S, Ratai EM. The use of magnetic resonance spectroscopy in the evaluation of epilepsy. Neuroimaging Clin N Am. 2013 Aug; 23(3):407-24. PMID: 23928197.
    Citations: 1     Fields:    Translation:Humans
  26. González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R. The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg. 2013 May; 5 Suppl 1:i7-12. PMID: 23493340; PMCID: PMC3623036.
    Citations: 16     Fields:    Translation:Humans
  27. Pomerantz SR, Kamalian S, Zhang D, Gupta R, Rapalino O, Sahani DV, Lev MH. Virtual monochromatic reconstruction of dual-energy unenhanced head CT at 65-75 keV maximizes image quality compared with conventional polychromatic CT. Radiology. 2013 Jan; 266(1):318-25. PMID: 23074259.
    Citations: 16     Fields:    Translation:Humans
  28. Musolino PL, Rapalino O, Caruso P, Caviness VS, Eichler FS. Hypoperfusion predicts lesion progression in cerebral X-linked adrenoleukodystrophy. Brain. 2012 Sep; 135(Pt 9):2676-83. PMID: 22961546; PMCID: PMC3437030.
    Citations: 10     Fields:    Translation:HumansCells
  29. Rapalino O, Kamalian S, Kamalian S, Payabvash S, Souza LC, Zhang D, Mukta J, Sahani DV, Lev MH, Pomerantz SR. Cranial CT with adaptive statistical iterative reconstruction: improved image quality with concomitant radiation dose reduction. AJNR Am J Neuroradiol. 2012 Apr; 33(4):609-15. PMID: 22207302.
    Citations: 31     Fields:    Translation:Humans
  30. Fearing MK, Israel EJ, Sahai I, Rapalino O, Lisovsky M. Case records of the Massachusetts General Hospital. Case 12-2011. A 9-month-old boy with acute liver failure. N Engl J Med. 2011 Apr 21; 364(16):1545-56. PMID: 21506744.
    Citations: 2     Fields:    Translation:Humans
  31. Jensen JH, Falangola MF, Hu C, Tabesh A, Rapalino O, Lo C, Helpern JA. Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction. NMR Biomed. 2011 Jun; 24(5):452-7. PMID: 20960579; PMCID: PMC3549661.
    Citations: 49     Fields:    Translation:Humans
  32. Greenberg SM, Rapalino O, Frosch MP. Case records of the Massachusetts General Hospital. Case 22-2010. An 87-year-old woman with dementia and a seizure. N Engl J Med. 2010 Jul 22; 363(4):373-81. PMID: 20660406.
    Citations: 3     Fields:    Translation:Humans
  33. Rapalino O. Thalamic anisotropy and functional disability. AJNR Am J Neuroradiol. 2009 Aug; 30(7):1387. PMID: 19509070.
    Citations: 1     Fields:    Translation:HumansCells
  34. Lin K, Rapalino O, Lee B, Do KG, Sussmann AR, Law M, Pramanik BK. Correlation of volumetric mismatch and mismatch of Alberta Stroke Program Early CT Scores on CT perfusion maps. Neuroradiology. 2009 Jan; 51(1):17-23. PMID: 18787815.
    Citations: 15     Fields:    Translation:Humans
  35. Lu H, Law M, Ge Y, Hesseltine SM, Rapalino O, Jensen JH, Helpern JA. Quantitative measurement of spinal cord blood volume in humans using vascular-space-occupancy MRI. NMR Biomed. 2008 Mar; 21(3):226-32. PMID: 17557363.
    Citations: 3     Fields:    Translation:Humans
  36. Rapalino OA, Levine DN. Developmental apraxia arising from neonatal brachial plexus palsy. Neurology. 2000 Dec 12; 55(11):1761. PMID: 11113250.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.