Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Ildiko Van Rhijn, Ph.D.

Title
Institution
Department
Address
Phone
Fax

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shahine A, Reinink P, Reijneveld JF, Gras S, Holzheimer M, Cheng TY, Minnaard AJ, Altman JD, Lenz S, Prandi J, Kubler-Kielb J, Moody DB, Rossjohn J, Van Rhijn I. A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids. Nat Commun. 2019 01 04; 10(1):56. PMID: 30610190.
    Citations:    Fields:    
  2. Wun KS, Reijneveld JF, Cheng TY, Ladell K, Uldrich AP, Le Nours J, Miners KL, McLaren JE, Grant EJ, Haigh OL, Watkins TS, Suliman S, Iwany S, Jimenez J, Calderon R, Tamara KL, Leon SR, Murray MB, Mayfield JA, Altman JD, Purcell AW, Miles JJ, Godfrey DI, Gras S, Price DA, Van Rhijn I, Moody DB, Rossjohn J. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nat Immunol. 2018 Apr; 19(4):397-406. PMID: 29531339.
    Citations: 3     Fields:    
  3. James CA, Yu KKQ, Gilleron M, Prandi J, Yedulla VR, Moleda ZZ, Diamanti E, Khan M, Aggarwal VK, Reijneveld JF, Reinink P, Lenz S, Emerson RO, Scriba TJ, Souter MNT, Godfrey DI, Pellicci DG, Moody DB, Minnaard AJ, Seshadri C, Van Rhijn I. CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis. Cell Chem Biol. 2018 04 19; 25(4):392-402.e14. PMID: 29398561.
    Citations: 2     Fields:    
  4. Gras S, Van Rhijn I, Shahine A, Le Nours J. Molecular recognition of microbial lipid-based antigens by T cells. Cell Mol Life Sci. 2018 05; 75(9):1623-1639. PMID: 29340708.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Shahine A, Van Rhijn I, Cheng TY, Iwany S, Gras S, Moody DB, Rossjohn J. A molecular basis of human T cell receptor autoreactivity toward self-phospholipids. Sci Immunol. 2017 10 20; 2(16). PMID: 29054999.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Van Rhijn I, Iwany SK, Fodran P, Cheng TY, Gapin L, Minnaard AJ, Moody DB. CD1b-mycolic acid tetramers demonstrate T-cell fine specificity for mycobacterial lipid tails. Eur J Immunol. 2017 09; 47(9):1525-1534. PMID: 28665555.
    Citations: 5     Fields:    Translation:HumansCells
  7. Bagchi S, He Y, Zhang H, Cao L, Van Rhijn I, Moody DB, Gudjonsson JE, Wang CR. CD1b-autoreactive T cells contribute to hyperlipidemia-induced skin inflammation in mice. J Clin Invest. 2017 Jun 01; 127(6):2339-2352. PMID: 28463230.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Cheng JM, Liu L, Pellicci DG, Reddiex SJ, Cotton RN, Cheng TY, Young DC, Van Rhijn I, Moody DB, Rossjohn J, Fairlie DP, Godfrey DI, Williams SJ. Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition. Chemistry. 2017 Jan 31; 23(7):1694-1701. PMID: 27925318.
    Citations: 1     Fields:    Translation:HumansCells
  9. Gras S, Van Rhijn I, Shahine A, Cheng TY, Bhati M, Tan LL, Halim H, Tuttle KD, Gapin L, Le Nours J, Moody DB, Rossjohn J. T cell receptor recognition of CD1b presenting a mycobacterial glycolipid. Nat Commun. 2016 10 27; 7:13257. PMID: 27807341.
    Citations: 9     Fields:    Translation:HumansCells
  10. Reinink P, Van Rhijn I. Mammalian CD1 and MR1 genes. Immunogenetics. 2016 Aug; 68(8):515-23. PMID: 27470004; PMCID: PMC5002277.
    Citations: 3     Fields:    Translation:HumansAnimals
  11. Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB. Human autoreactive T cells recognize CD1b and phospholipids. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):380-5. PMID: 26621732.
    Citations:    
  12. Van Rhijn I, Godfrey DI, Rossjohn J, Moody DB. Lipid and small-molecule display by CD1 and MR1. Nat Rev Immunol. 2015 Oct; 15(10):643-54. PMID: 26388332.
    Citations: 40     Fields:    Translation:HumansCells
  13. Van Rhijn I, Moody DB. Donor Unrestricted T Cells: A Shared Human T Cell Response. J Immunol. 2015 Sep 01; 195(5):1927-32. PMID: 26297792; PMCID: PMC4549802.
    Citations: 10     Fields:    Translation:HumansCells
  14. Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I. Correction: Expression Patterns of Bovine CD1 In Vivo and Assessment of the Specificities of the Anti-Bovine CD1 Antibodies. PLoS One. 2015; 10(6):e0129755. PMID: 26046785; PMCID: PMC4457881.
    Citations:    Fields:    
  15. Nguyen TK, Reinink P, El Messlaki C, Im JS, Ercan A, Porcelli SA, Van Rhijn I. Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies. PLoS One. 2015; 10(3):e0121923. PMID: 25815476; PMCID: PMC4376853.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Van Rhijn I, Moody DB. CD1 and mycobacterial lipids activate human T cells. Immunol Rev. 2015 Mar; 264(1):138-53. PMID: 25703557; PMCID: PMC4339259.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. van Schaik B, Klarenbeek P, Doorenspleet M, van Kampen A, Moody DB, de Vries N, Van Rhijn I. Discovery of invariant T cells by next-generation sequencing of the human TCR a-chain repertoire. J Immunol. 2014 Nov 15; 193(10):5338-44. PMID: 25339678; PMCID: PMC4225161.
    Citations: 9     Fields:    Translation:HumansCells
  18. Kawasaki N, Rillahan CD, Cheng TY, Van Rhijn I, Macauley MS, Moody DB, Paulson JC. Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation. J Immunol. 2014 Aug 15; 193(4):1560-6. PMID: 25000981; PMCID: PMC4119498.
    Citations: 11     Fields:    Translation:HumansCells
  19. Van Rhijn I, Gherardin NA, Kasmar A, de Jager W, Pellicci DG, Kostenko L, Tan LL, Bhati M, Gras S, Godfrey DI, Rossjohn J, Moody DB. TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire. J Immunol. 2014 May 01; 192(9):4054-60. PMID: 24683194; PMCID: PMC4019959.
    Citations: 23     Fields:    Translation:HumansCells
  20. de Jong A, Cheng TY, Huang S, Gras S, Birkinshaw RW, Kasmar AG, Van Rhijn I, Peña-Cruz V, Ruan DT, Altman JD, Rossjohn J, Moody DB. CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens. Nat Immunol. 2014 Feb; 15(2):177-85. PMID: 24362891; PMCID: PMC3932764.
    Citations: 52     Fields:    Translation:HumansCells
  21. Kasmar AG, Van Rhijn I, Magalhaes KG, Young DC, Cheng TY, Turner MT, Schiefner A, Kalathur RC, Wilson IA, Bhati M, Gras S, Birkinshaw RW, Tan LL, Rossjohn J, Shires J, Jakobsen S, Altman JD, Moody DB. Cutting Edge: CD1a tetramers and dextramers identify human lipopeptide-specific T cells ex vivo. J Immunol. 2013 Nov 01; 191(9):4499-503. PMID: 24089190; PMCID: PMC3845436.
    Citations: 25     Fields:    Translation:HumansCells
  22. Van Rhijn I, Kasmar A, de Jong A, Gras S, Bhati M, Doorenspleet ME, de Vries N, Godfrey DI, Altman JD, de Jager W, Rossjohn J, Moody DB. A conserved human T cell population targets mycobacterial antigens presented by CD1b. Nat Immunol. 2013 Jul; 14(7):706-13. PMID: 23727893; PMCID: PMC3723453.
    Citations: 67     Fields:    Translation:HumansCells
  23. López-Sagaseta J, Dulberger CL, Crooks JE, Parks CD, Luoma AM, McFedries A, Van Rhijn I, Saghatelian A, Adams EJ. The molecular basis for Mucosal-Associated Invariant T cell recognition of MR1 proteins. Proc Natl Acad Sci U S A. 2013 May 07; 110(19):E1771-8. PMID: 23613577.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  24. Van Rhijn I, Ly D, Moody DB. CD1a, CD1b, and CD1c in immunity against mycobacteria. Adv Exp Med Biol. 2013; 783:181-97. PMID: 23468110.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  25. Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I. Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis. J Immunol. 2013 Jan 01; 190(1):278-84. PMID: 23197260; PMCID: PMC3529834.
    Citations: 9     Fields:    Translation:HumansCells
  26. Wang J, Guillaume J, Pauwels N, Van Calenbergh S, Van Rhijn I, Zajonc DM. Crystal structures of bovine CD1d reveal altered aGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids. PLoS One. 2012; 7(10):e47989. PMID: 23110152.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  27. Looringh van Beeck FA, Leegwater PA, Herrmann T, Broere F, Rutten VP, Willemse T, Van Rhijn I. Tandem repeats modify the structure of the canine CD1D gene. Anim Genet. 2013 Jun; 44(3):352-5. PMID: 22988997.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Nguyen TK, Koets AP, Vordermeier M, Jervis PJ, Cox LR, Graham SP, Santema WJ, Moody DB, van Calenbergh S, Zajonc DM, Besra GS, Van Rhijn I. The bovine CD1D gene has an unusual gene structure and is expressed but cannot present a-galactosylceramide with a C26 fatty acid. Int Immunol. 2013 Feb; 25(2):91-8. PMID: 22968995; PMCID: PMC3619971.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  29. Vrieling M, Santema W, Van Rhijn I, Rutten V, Koets A. ?d T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent. J Immunol. 2012 Jan 15; 188(2):578-84. PMID: 22156593.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Kasmar AG, van Rhijn I, Cheng TY, Turner M, Seshadri C, Schiefner A, Kalathur RC, Annand JW, de Jong A, Shires J, Leon L, Brenner M, Wilson IA, Altman JD, Moody DB. CD1b tetramers bind aß T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans. J Exp Med. 2011 Aug 29; 208(9):1741-7. PMID: 21807869; PMCID: PMC3171094.
    Citations: 52     Fields:    Translation:HumansCells
  31. Nguyen TK, Wieland W, Santema W, Hoeboer J, van Eden W, Rutten V, Koets A, Van Rhijn I. Immune response of cattle immunized with a conjugate of the glycolipid glucose monomycolate and protein. Vet Immunol Immunopathol. 2011 Aug 15; 142(3-4):265-70. PMID: 21640388.
    Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
  32. de Jong A, Peña-Cruz V, Cheng TY, Clark RA, Van Rhijn I, Moody DB. CD1a-autoreactive T cells are a normal component of the human aß T cell repertoire. Nat Immunol. 2010 Dec; 11(12):1102-9. PMID: 21037579; PMCID: PMC3131223.
    Citations: 96     Fields:    Translation:HumansCells
  33. Girardi E, Wang J, Mac TT, Versluis C, Bhowruth V, Besra G, Heck AJ, Van Rhijn I, Zajonc DM. Crystal structure of bovine CD1b3 with endogenously bound ligands. J Immunol. 2010 Jul 01; 185(1):376-86. PMID: 20519644.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  34. Goldfinch N, Reinink P, Connelley T, Koets A, Morrison I, Van Rhijn I. Conservation of mucosal associated invariant T (MAIT) cells and the MR1 restriction element in ruminants, and abundance of MAIT cells in spleen. Vet Res. 2010 Sep-Oct; 41(5):62. PMID: 20507818.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  35. Van Rhijn I, Nguyen TK, Michel A, Cooper D, Govaerts M, Cheng TY, van Eden W, Moody DB, Coetzer JA, Rutten V, Koets AP. Low cross-reactivity of T-cell responses against lipids from Mycobacterium bovis and M. avium paratuberculosis during natural infection. Eur J Immunol. 2009 Nov; 39(11):3031-41. PMID: 19688747; PMCID: PMC3136192.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Maas M, Van Rhijn I, Allsopp MT, Rutten VP. Lion (Panthera leo) and cheetah (Acinonyx jubatus) IFN-gamma sequences. Vet Immunol Immunopathol. 2010 Apr 15; 134(3-4):296-8. PMID: 19913304.
    Citations:    Fields:    Translation:AnimalsCells
  37. Reinink P, Van Rhijn I. The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2. Immunogenetics. 2009 Jul; 61(7):541-9. PMID: 19568741; PMCID: PMC2706379.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  38. Kasmar A, Van Rhijn I, Moody DB. The evolved functions of CD1 during infection. Curr Opin Immunol. 2009 Aug; 21(4):397-403. PMID: 19541469; PMCID: PMC2725205.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  39. Nguyen TK, Koets AP, Santema WJ, van Eden W, Rutten VP, Van Rhijn I. The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle. Vaccine. 2009 Jul 30; 27(35):4818-25. PMID: 19538998; PMCID: PMC2719691.
    Citations: 10     Fields:    Translation:AnimalsCells
  40. Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 08; 206(6):1409-22. PMID: 19468063; PMCID: PMC2715062.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  41. Looringh van Beeck FA, Reinink P, Hermsen R, Zajonc DM, Laven MJ, Fun A, Troskie M, Schoemaker NJ, Morar D, Lenstra JA, Vervelde L, Rutten VP, van Eden W, Van Rhijn I. Functional CD1d and/or NKT cell invariant chain transcript in horse, pig, African elephant and guinea pig, but not in ruminants. Mol Immunol. 2009 Apr; 46(7):1424-31. PMID: 19185921; PMCID: PMC2669151.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  42. Hoek A, Rutten VP, Kool J, Arkesteijn GJ, Bouwstra RJ, Van Rhijn I, Koets AP. Subpopulations of bovine WC1(+) gammadelta T cells rather than CD4(+)CD25(high) Foxp3(+) T cells act as immune regulatory cells ex vivo. Vet Res. 2009 Jan-Feb; 40(1):6. PMID: 18928784; PMCID: PMC2695017.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  43. Looringh van Beeck FA, Zajonc DM, Moore PF, Schlotter YM, Broere F, Rutten VP, Willemse T, Van Rhijn I. Two canine CD1a proteins are differentially expressed in skin. Immunogenetics. 2008 Jun; 60(6):315-24. PMID: 18488214; PMCID: PMC2668647.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  44. Van Rhijn I, Godfroid J, Michel A, Rutten V. Bovine tuberculosis as a model for human tuberculosis: advantages over small animal models. Microbes Infect. 2008 Jun; 10(7):711-5. PMID: 18538612.
    Citations: 18     Fields:    Translation:HumansAnimals
  45. Van Rhijn I, Spiering R, Smits M, van Blokland MT, de Weger R, van Eden W, Rutten VP, Koets AP. Highly diverse TCR delta chain repertoire in bovine tissues due to the use of up to four D segments per delta chain. Mol Immunol. 2007 May; 44(12):3155-61. PMID: 17418895.
    Citations: 6     Fields:    Translation:AnimalsCells
  46. Van Rhijn I, Rutten VPMG, Charleston B, Smits M, van Eden W, Koets AP. Massive, sustained ?d T cell migration from the bovine skin in vivo. J Leukoc Biol. 2007 Apr; 81(4):968-973. PMID: 29350847.
    Citations:    Fields:    
  47. Van Rhijn I, Rutten VP, Charleston B, Smits M, van Eden W, Koets AP. Massive, sustained gammadelta T cell migration from the bovine skin in vivo. J Leukoc Biol. 2007 Apr; 81(4):968-73. PMID: 17234682.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Cheng TY, Relloso M, Van Rhijn I, Young DC, Besra GS, Briken V, Zajonc DM, Wilson IA, Porcelli S, Moody DB. Role of lipid trimming and CD1 groove size in cellular antigen presentation. EMBO J. 2006 Jul 12; 25(13):2989-99. PMID: 16794581; PMCID: PMC1500985.
    Citations: 23     Fields:    Translation:HumansCells
  49. Van Rhijn I, Koets AP, Im JS, Piebes D, Reddington F, Besra GS, Porcelli SA, van Eden W, Rutten VP. The bovine CD1 family contains group 1 CD1 proteins, but no functional CD1d. J Immunol. 2006 Apr 15; 176(8):4888-93. PMID: 16585584.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  50. Van Rhijn I, Zajonc DM, Wilson IA, Moody DB. T-cell activation by lipopeptide antigens. Curr Opin Immunol. 2005 Jun; 17(3):222-9. PMID: 15886110.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  51. Van Rhijn I, Young DC, Im JS, Levery SB, Illarionov PA, Besra GS, Porcelli SA, Gumperz J, Cheng TY, Moody DB. CD1d-restricted T cell activation by nonlipidic small molecules. Proc Natl Acad Sci U S A. 2004 Sep 14; 101(37):13578-83. PMID: 15342907; PMCID: PMC518797.
    Citations: 38     Fields:    Translation:HumansCells
  52. Van Rhijn I, Logtenberg T, Ang CW, Van den Berg LH. Gammadelta T cell non-responsiveness in Campylobacter jejuni-associated Guillain-Barré syndrome patients. Neurology. 2003 Oct 14; 61(7):994-6. PMID: 14557578.
    Citations: 1     Fields:    Translation:HumansCells
  53. Van Rhijn I, Van den Berg LH, Ang CW, Admiraal J, Logtenberg T. Expansion of human gammadelta T cells after in vitro stimulation with Campylobacter jejuni. Int Immunol. 2003 Mar; 15(3):373-82. PMID: 12618481.
    Citations: 2     Fields:    Translation:HumansCells
  54. Van Rhijn I, Bleumink-Pluym NM, Van Putten JP, Van den Berg LH. Campylobacter DNA is present in circulating myelomonocytic cells of healthy persons and in persons with Guillain-Barré syndrome. J Infect Dis. 2002 Jan 15; 185(2):262-5. PMID: 11807702.
    Citations: 2     Fields:    Translation:HumansCells
  55. Van Rhijn I, Van den Berg LH, Bosboom WM, Otten HG, Logtenberg T. Expression of accessory molecules for T-cell activation in peripheral nerve of patients with CIDP and vasculitic neuropathy. Brain. 2000 Oct; 123 ( Pt 10):2020-9. PMID: 11004119.
    Citations: 7     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Van Rhijn's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (252)
Explore
_
Co-Authors (7)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.