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profileRobert S. Langer, SC.D.

TitleSenior Lecturer on Surgery, Part-time
InstitutionMassachusetts Institute of Technology
DepartmentSurgery
AddressMIT - Bldg E25-342
Cambridge MA 02139
Phone617/253-3107
Fax617/258-8827
vCardDownload vCard (login for email)
Other Positions
TitleMember of the Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


Collapse Mentoring 
Collapse completed student projects
Development of a Chlorhexidine Polymer Drug Delivery Vehicle fo rthe Treatment of Periodontal Disease
Part Time/Continuation, 09/01/99 - 06/30/00
Polyorthoester-Based Microspheres as Potentail Endosomolytic Transfection Modulators
Summer, 05/22/00 - 08/31/00

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01EB016101     (LANGER, ROBERT SAMUEL)Apr 1, 2013 - Feb 28, 2018
NIH/NIBIB
A New Device for Electrical & Chemical Modulation of Pathological Neural Activity
Role: Co-Principal Investigator

U54CA151884     (LANGER, ROBERT SAMUEL)Sep 1, 2010 - Jul 31, 2015
NIH/NCI
MIT-Harvard Center of Cancer Nanotechnology Excellence
Role: Principal Investigator

RC1DE020761     (ANDERSON, DANIEL G)Mar 9, 2010 - Sep 30, 2013
NIH/NIDCR
Human Pluripotent Stem Cell Differentiation with Defined O2 &Protein Engagement
Role: Co-Principal Investigator

RC1EB011187     (ANDERSON, DANIEL G)Sep 30, 2009 - Aug 31, 2011
NIH/NIBIB
High throughput cell reprogramming by microfluidic jet injection
Role: Co-Principal Investigator

U54CA119349     (LANGER, ROBERT SAMUEL)Sep 30, 2005 - Aug 31, 2011
NIH/NCI
The MIT-Harvard Center of Cancer Nanotechnology Excelle*
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Schoellhammer CM, Chen Y, Cleveland C, Minahan D, Bensel T, Park JY, Saxton S, Lee YL, Booth L, Langer R, Traverso G. Defining optimal permeant characteristics for ultrasound-mediated gastrointestinal delivery. J Control Release. 2017 Oct 16; 268:113-119. PMID: 29051063.
    View in: PubMed
  2. Spencer KC, Sy JC, Ramadi KB, Graybiel AM, Langer R, Cima MJ. Erratum: Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants. Sci Rep. 2017 Oct 09; 7(1):12812. PMID: 28993678.
    View in: PubMed
  3. Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics. Nat Commun. 2017 Oct 03; 8(1):777. PMID: 28974673.
    View in: PubMed
  4. Aday S, Zoldan J, Besnier M, Carreto L, Saif J, Fernandes R, Santos T, Bernardino L, Langer R, Emanueli C, Ferreira L. Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition. Nat Commun. 2017 Sep 29; 8(1):747. PMID: 28963481.
    View in: PubMed
  5. Bakh NA, Cortinas AB, Weiss MA, Langer RS, Anderson DG, Gu Z, Dutta S, Strano MS. Glucose-responsive insulin by molecular and physical design. Nat Chem. 2017 Sep 22; 9(10):937-943. PMID: 28937662.
    View in: PubMed
  6. McHugh KJ, Nguyen TD, Linehan AR, Yang D, Behrens AM, Rose S, Tochka ZL, Tzeng SY, Norman JJ, Anselmo AC, Xu X, Tomasic S, Taylor MA, Lu J, Guarecuco R, Langer R, Jaklenec A. Fabrication of fillable microparticles and other complex 3D microstructures. Science. 2017 09 15; 357(6356):1138-1142. PMID: 28912242.
    View in: PubMed
  7. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nat Nanotechnol. 2017 Sep 06; 12(9):845-855. PMID: 28875984.
    View in: PubMed
  8. Schneider C, Langer R, Loveday D, Hair D. Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems. J Control Release. 2017 Sep 28; 262:284-295. PMID: 28789964.
    View in: PubMed
  9. Caffarel-Salvador E, Abramson A, Langer R, Traverso G. Oral delivery of biologics using drug-device combinations. Curr Opin Pharmacol. 2017 Aug 02; 36:8-13. PMID: 28779684.
    View in: PubMed
  10. Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD. Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins. Nucleic Acids Res. 2017 Jul 27; 45(13):7602-7614. PMID: 28641400.
    View in: PubMed
  11. Liu J, Pang Y, Zhang S, Cleveland C, Yin X, Booth L, Lin J, Lucy Lee YA, Mazdiyasni H, Saxton S, Kirtane AR, Erlach TV, Rogner J, Langer R, Traverso G. Triggerable tough hydrogels for gastric resident dosage forms. Nat Commun. 2017 07 25; 8(1):124. PMID: 28743858.
    View in: PubMed
  12. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. J Clin Invest. 2017 Aug 01; 127(8):3039-3051. PMID: 28691930.
    View in: PubMed
  13. Yu D, Khan OF, Suvà ML, Dong B, Panek WK, Xiao T, Wu M, Han Y, Ahmed AU, Balyasnikova IV, Zhang HF, Sun C, Langer R, Anderson DG, Lesniak MS. Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression. Proc Natl Acad Sci U S A. 2017 Jul 25; 114(30):E6147-E6156. PMID: 28696296.
    View in: PubMed
  14. Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG. Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes. Adv Mater. 2017 Sep; 29(33). PMID: 28681930.
    View in: PubMed
  15. Guarecuco R, Lu J, McHugh KJ, Norman JJ, Thapa LS, Lydon E, Langer R, Jaklenec A. Immunogenicity of pulsatile-release PLGA microspheres for single-injection vaccination. Vaccine. 2017 Jun 15. PMID: 28625520.
    View in: PubMed
  16. Giwa S, Lewis JK, Alvarez L, Langer R, Roth AE, Church GM, Markmann JF, Sachs DH, Chandraker A, Wertheim JA, Rothblatt M, Boyden ES, Eidbo E, Lee WPA, Pomahac B, Brandacher G, Weinstock DM, Elliott G, Nelson D, Acker JP, Uygun K, Schmalz B, Weegman BP, Tocchio A, Fahy GM, Storey KB, Rubinsky B, Bischof J, Elliott JAW, Woodruff TK, Morris GJ, Demirci U, Brockbank KGM, Woods EJ, Ben RN, Baust JG, Gao D, Fuller B, Rabin Y, Kravitz DC, Taylor MJ, Toner M. The promise of organ and tissue preservation to transform medicine. Nat Biotechnol. 2017 Jun 07; 35(6):530-542. PMID: 28591112.
    View in: PubMed
  17. Zwang Y, Jonas O, Chen C, Rinne ML, Doench JG, Piccioni F, Tan L, Huang HT, Wang J, Ham YJ, O'Connell J, Bhola P, Doshi M, Whitman M, Cima M, Letai A, Root DE, Langer RS, Gray N, Hahn WC. Synergistic interactions with PI3K inhibition that induce apoptosis. Elife. 2017 May 31; 6. PMID: 28561737.
    View in: PubMed
  18. Spencer KC, Sy JC, Ramadi KB, Graybiel AM, Langer R, Cima MJ. Characterization of Mechanically Matched Hydrogel Coatings to Improve the Biocompatibility of Neural Implants. Sci Rep. 2017 May 16; 7(1):1952. PMID: 28512291.
    View in: PubMed
  19. Roper J, Tammela T, Cetinbas NM, Akkad A, Roghanian A, Rickelt S, Almeqdadi M, Wu K, Oberli MA, Sánchez-Rivera F, Park YK, Liang X, Eng G, Taylor MS, Azimi R, Kedrin D, Neupane R, Beyaz S, Sicinska ET, Suarez Y, Yoo J, Chen L, Zukerberg L, Katajisto P, Deshpande V, Bass AJ, Tsichlis PN, Lees J, Langer R, Hynes RO, Chen J, Bhutkar A, Jacks T, Yilmaz ÖH. In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis. Nat Biotechnol. 2017 Jun; 35(6):569-576. PMID: 28459449.
    View in: PubMed
  20. Cha Y, Han MJ, Cha HJ, Zoldan J, Burkart A, Jung JH, Jang Y, Kim CH, Jeong HC, Kim BG, Langer R, Kahn CR, Guarente L, Kim KS. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Nat Cell Biol. 2017 May; 19(5):445-456. PMID: 28436968.
    View in: PubMed
  21. Tibbitt MW, Langer R. Living Biomaterials. Acc Chem Res. 2017 Mar 21; 50(3):508-513. PMID: 28945422.
    View in: PubMed
  22. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 Mar 20; 8:14179. PMID: 28317839.
    View in: PubMed
  23. Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG. Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates. Nat Mater. 2017 Jun; 16(6):671-680. PMID: 28319612.
    View in: PubMed
  24. Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG. Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks. Adv Mater. 2017 May; 29(19). PMID: 28295624.
    View in: PubMed
  25. Schwerdt HN, Kim MJ, Amemori S, Homma D, Yoshida T, Shimazu H, Yerramreddy H, Karasan E, Langer R, Graybiel AM, Cima MJ. Subcellular probes for neurochemical recording from multiple brain sites. Lab Chip. 2017 Mar 14; 17(6):1104-1115. PMID: 28233001.
    View in: PubMed
  26. Ding X, Stewart M, Sharei A, Weaver JC, Langer RS, Jensen KF. High-throughput Nuclear Delivery and Rapid Expression of DNA via Mechanical and Electrical Cell-Membrane Disruption. Nat Biomed Eng. 2017; 1. PMID: 28932622.
    View in: PubMed
  27. Ragelle H, Naba A, Larson BL, Zhou F, Prijic M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG. Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials. 2017 Jun; 128:147-159. PMID: 28327460.
    View in: PubMed
  28. McLean WJ, Yin X, Lu L, Lenz DR, McLean D, Langer R, Karp JM, Edge ASB. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Cell Rep. 2017 Feb 21; 18(8):1917-1929. PMID: 28228258.
    View in: PubMed
  29. Dahlman JE, Kauffman KJ, Xing Y, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET. Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics. Proc Natl Acad Sci U S A. 2017 Feb 21; 114(8):2060-2065. PMID: 28167778.
    View in: PubMed
  30. Nadeau P, El-Damak D, Glettig D, Kong YL, Mo S, Cleveland C, Booth L, Roxhed N, Langer R, Chandrakasan AP, Traverso G. Prolonged energy harvesting for ingestible devices. Nat Biomed Eng. 2017; 1. PMID: 28458955.
    View in: PubMed
  31. van der Ven CF, Wu PJ, Tibbitt MW, van Mil A, Sluijter JP, Langer R, Aikawa E. In vitro 3D model and miRNA drug delivery to target calcific aortic valve disease. Clin Sci (Lond). 2017 Feb 01; 131(3):181-195. PMID: 28057890.
    View in: PubMed
  32. Slotkin JR, Pritchard CD, Luque B, Ye J, Layer RT, Lawrence MS, O'Shea TM, Roy RR, Zhong H, Vollenweider I, Edgerton VR, Courtine G, Woodard EJ, Langer R. Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury. Biomaterials. 2017 Apr; 123:63-76. PMID: 28167393.
    View in: PubMed
  33. Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology. 2017 Apr; 152(5):1151-1160. PMID: 28088460.
    View in: PubMed
  34. Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG. Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors. Nat Med. 2017 Feb; 23(2):235-241. PMID: 28024083.
    View in: PubMed
  35. Luo X, Wang W, Dorkin JR, Veiseh O, Chang PH, Abutbul-Ionita I, Danino D, Langer R, Anderson DG, Dong Y. Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo. Biomater Sci. 2016 Dec 20; 5(1):38-40. PMID: 27921096.
    View in: PubMed
  36. Yesilyurt V, Veiseh O, Doloff JC, Li J, Bose S, Xie X, Bader AR, Chen M, Webber MJ, Vegas AJ, Langer R, Anderson DG. A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings. Adv Healthc Mater. 2017 Feb; 6(4). PMID: 27976536.
    View in: PubMed
  37. Langer R, Basu A, Domb AJ. Special issue: Polylactide (PLA) Based Biopolymers. Adv Drug Deliv Rev. 2016 Dec 15; 107:1-2. PMID: 27938692.
    View in: PubMed
  38. Zugates GT, Peng W, Zumbuehl A, Jhunjhunwala S, Huang YH, Langer R, Sawicki JA, Anderson DG. Rapid Optimization of Gene Delivery by Parallel End-modification of Poly(ß-amino ester)s. Mol Ther. 2007 Jul; 15(7):1306-1312. PMID: 28182918.
    View in: PubMed
  39. Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 03 08; 17(3):1326-1335. PMID: 28273716.
    View in: PubMed
  40. Webber MJ, Appel EA, Vinciguerra B, Cortinas AB, Thapa LS, Jhunjhunwala S, Isaacs L, Langer R, Anderson DG. Supramolecular PEGylation of biopharmaceuticals. Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50):14189-14194. PMID: 27911829.
    View in: PubMed
  41. Bellinger AM, Jafari M, Grant TM, Zhang S, Slater HC, Wenger EA, Mo S, Lee YL, Mazdiyasni H, Kogan L, Barman R, Cleveland C, Booth L, Bensel T, Minahan D, Hurowitz HM, Tai T, Daily J, Nikolic B, Wood L, Eckhoff PA, Langer R, Traverso G. Oral, ultra-long-lasting drug delivery: Application toward malaria elimination goals. Sci Transl Med. 2016 Nov 16; 8(365):365ra157. PMID: 27856796.
    View in: PubMed
  42. Kirtane AR, Langer R, Traverso G. Past, Present, and Future Drug Delivery Systems for Antiretrovirals. J Pharm Sci. 2016 Dec; 105(12):3471-3482. PMID: 27771050.
    View in: PubMed
  43. Ragelle H, Danhier F, Préat V, Langer R, Anderson DG. Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures. Expert Opin Drug Deliv. 2017 Jul; 14(7):851-864. PMID: 27730820.
    View in: PubMed
  44. Stewart MP, Sharei A, Ding X, Sahay G, Langer R, Jensen KF. In vitro and ex vivo strategies for intracellular delivery. Nature. 2016 10 13; 538(7624):183-192. PMID: 27734871.
    View in: PubMed
  45. Tam HH, Melo MB, Kang M, Pelet JM, Ruda VM, Foley MH, Hu JK, Kumari S, Crampton J, Baldeon AD, Sanders RW, Moore JP, Crotty S, Langer R, Anderson DG, Chakraborty AK, Irvine DJ. Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination. Proc Natl Acad Sci U S A. 2016 Oct 25; 113(43):E6639-E6648. PMID: 27702895.
    View in: PubMed
  46. Anselmo AC, McHugh KJ, Webster J, Langer R, Jaklenec A. Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome. Adv Mater. 2016 Nov; 28(43):9486-9490. PMID: 27616140.
    View in: PubMed
  47. Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Interaction between integrin a5 and PDE4D regulates endothelial inflammatory signalling. Nat Cell Biol. 2016 Oct; 18(10):1043-53. PMID: 27595237.
    View in: PubMed
  48. Saung MT, Sharei A, Adalsteinsson VA, Cho N, Kamath T, Ruiz C, Kirkpatrick J, Patel N, Mino-Kenudson M, Thayer SP, Langer R, Jensen KF, Liss AS, Love JC. A Size-Selective Intracellular Delivery Platform. Small. 2016 Sep 04. PMID: 27594517.
    View in: PubMed
  49. Khademhosseini A, Langer R. A decade of progress in tissue engineering. Nat Protoc. 2016 Oct; 11(10):1775-81. PMID: 27583639.
    View in: PubMed
  50. Adlington K, Nguyen NT, Eaves E, Yang J, Chang CY, Li J, Gower AL, Stimpson A, Anderson DG, Langer R, Davies MC, Hook AL, Williams P, Alexander MR, Irvine DJ. Application of Targeted Molecular and Material Property Optimization to Bacterial Attachment-Resistant (Meth)acrylate Polymers. Biomacromolecules. 2016 Sep 12; 17(9):2830-8. PMID: 27461341.
    View in: PubMed
  51. Dong Y, Wang W, Veiseh O, Appel EA, Xue K, Webber MJ, Tang BC, Yang XW, Weir GC, Langer R, Anderson DG. Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation. Langmuir. 2016 Aug 30; 32(34):8743-7. PMID: 27455412.
    View in: PubMed
  52. Hammad M, Rao W, Smith JG, Anderson DG, Langer R, Young LE, Barrett DA, Davies MC, Denning C, Alexander MR. Identification of polymer surface adsorbed proteins implicated in pluripotent human embryonic stem cell expansion. Biomater Sci. 2016 Aug 16; 4(9):1381-91. PMID: 27466628.
    View in: PubMed
  53. Chertok B, Langer R, Anderson DG. Spatial Control of Gene Expression by Nanocarriers Using Heparin Masking and Ultrasound-Targeted Microbubble Destruction. ACS Nano. 2016 Aug 23; 10(8):7267-78. PMID: 27472268.
    View in: PubMed
  54. Detappe A, Kunjachan S, Sancey L, Motto-Ros V, Biancur D, Drane P, Guieze R, Makrigiorgos GM, Tillement O, Langer R, Berbeco R. Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy. J Control Release. 2016 Sep 28; 238:103-113. PMID: 27423325.
    View in: PubMed
  55. Lee HC, Ahsen OO, Liang K, Wang Z, Cleveland C, Booth L, Potsaid B, Jayaraman V, Cable AE, Mashimo H, Langer R, Traverso G, Fujimoto JG. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter. Biomed Opt Express. 2016 Aug 01; 7(8):2927-42. PMID: 27570688; PMCID: PMC4986804.
  56. Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):E4133-42. PMID: 27382155; PMCID: PMC4961123 [Available on 01/19/17].
  57. Kanasty RL, Vegas AJ, Ceo LM, Maier M, Charisse K, Nair JK, Langer R, Anderson DG. Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications. Angew Chem Int Ed Engl. 2016 Aug 08; 55(33):9529-33. PMID: 27365192.
    View in: PubMed
  58. Farah S, Anderson DG, Langer R. Physical and mechanical properties of PLA, and their functions in widespread applications - A comprehensive review. Adv Drug Deliv Rev. 2016 Dec 15; 107:367-392. PMID: 27356150.
    View in: PubMed
  59. Hong AL, Tseng YY, Cowley GS, Jonas O, Cheah JH, Kynnap BD, Doshi MB, Oh C, Meyer SC, Church AJ, Gill S, Bielski CM, Keskula P, Imamovic A, Howell S, Kryukov GV, Clemons PA, Tsherniak A, Vazquez F, Crompton BD, Shamji AF, Rodriguez-Galindo C, Janeway KA, Roberts CW, Stegmaier K, van Hummelen P, Cima MJ, Langer RS, Garraway LA, Schreiber SL, Root DE, Hahn WC, Boehm JS. Integrated genetic and pharmacologic interrogation of rare cancers. Nat Commun. 2016 Jun 22; 7:11987. PMID: 27329820; PMCID: PMC4917959.
  60. Zhang YS, Duchamp M, Oklu R, Ellisen LW, Langer R, Khademhosseini A. Bioprinting the Cancer Microenvironment. ACS Biomater Sci Eng. 2016 Oct 10; 2(10):1710-1721. PMID: 28251176.
    View in: PubMed
  61. Morgan KY, Sklaviadis D, Tochka ZL, Fischer KM, Hearon K, Morgan TD, Langer R, Freed LE. Multi-Material Tissue Engineering Scaffold with Hierarchical Pore Architecture. Adv Funct Mater. 2016 Aug 23; 26(32):5873-5883. PMID: 27942257.
    View in: PubMed
  62. Chen X, Wu B, Jayawardana KW, Hao N, Jayawardena HS, Langer R, Jaklenec A, Yan M. Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria. Adv Healthc Mater. 2016 Aug; 5(16):2007-12. PMID: 27283385.
    View in: PubMed
  63. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 Jun 09; 34(6):666. PMID: 27281428.
    View in: PubMed
  64. Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M. RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction. Sci Transl Med. 2016 Jun 08; 8(342):342ra80. PMID: 27280687.
    View in: PubMed
  65. Zhao X, Hwang NS, Bichara DA, Saris DB, Malda J, Vacanti JP, Pomerantseva I, Sundback CA, Langer R, Anderson DG, Randolph MA. Chondrogenesis by bone marrow-derived mesenchymal stem cells grown in chondrocyte-conditioned medium for auricular reconstruction. J Tissue Eng Regen Med. 2017 Oct; 11(10):2763-2773. PMID: 27256796.
    View in: PubMed
  66. Jonas O, Calligaris D, Methuku KR, Poe MM, Francois JP, Tranghese F, Changelian A, Sieghart W, Ernst M, Krummel DA, Cook JM, Pomeroy SL, Cima M, Agar NY, Langer R, Sengupta S. First In Vivo Testing of Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development. J Biomed Nanotechnol. 2016 Jun; 12(6):1297-302. PMID: 27319222.
    View in: PubMed
  67. Tzeng SY, Guarecuco R, McHugh KJ, Rose S, Rosenberg EM, Zeng Y, Langer R, Jaklenec A. Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release. J Control Release. 2016 Jul 10; 233:101-13. PMID: 27178811; PMCID: PMC4925381.
  68. Yu B, Kang SY, Akthakul A, Ramadurai N, Pilkenton M, Patel A, Nashat A, Anderson DG, Sakamoto FH, Gilchrest BA, Anderson RR, Langer R. An elastic second skin. Nat Mater. 2016 Aug; 15(8):911-8. PMID: 27159017.
    View in: PubMed
  69. Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y. The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages. Nat Commun. 2016 May 06; 7:11385. PMID: 27150562; PMCID: PMC4859070.
  70. Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5552-7. PMID: 27140638; PMCID: PMC4878518 [Available on 11/17/16].
  71. Kimball AB, Javorsky E, Ron ES, Crowley W, Langer R. A novel approach to administration of peptides in women: Systemic absorption of a GnRH agonist via transvaginal ring delivery system. J Control Release. 2016 Jul 10; 233:19-28. PMID: 27130696.
    View in: PubMed
  72. Taylor L, Arnér K, Kolewe M, Pritchard C, Hendy G, Langer R, Ghosh F. Seeing through the interface: poly(e-Caprolactone) surface modification of poly(glycerol-co-sebacic acid) membranes in adult porcine retinal explants. J Tissue Eng Regen Med. 2017 Aug; 11(8):2349-2358. PMID: 27098673.
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  330. Bruggeman JP, Bettinger CJ, Langer R. Biodegradable xylitol-based elastomers: in vivo behavior and biocompatibility. J Biomed Mater Res A. 2010 Oct; 95(1):92-104. PMID: 20540093; PMCID: PMC2935807.
  331. Wang J, Bettinger CJ, Langer RS, Borenstein JT. Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers. Organogenesis. 2010 Oct-Dec; 6(4):212-6. PMID: 21220957; PMCID: PMC3055646.
  332. Pritchard CD, O'Shea TM, Siegwart DJ, Calo E, Anderson DG, Reynolds FM, Thomas JA, Slotkin JR, Woodard EJ, Langer R. An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate. Biomaterials. 2011 Jan; 32(2):587-97. PMID: 20880573; PMCID: PMC4070531.
  333. De Sousa FB, Guerreiro JD, Ma M, Anderson DG, Drum CL, Sinisterra RD, Langer R. Photo-response behavior of electrospun nanofibers based on spiropyran-cyclodextrin modified polymer. J Mater Chem. 2010 Nov 28; 20(44):9910-9917. PMID: 28210069.
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  335. Yang J, Mei Y, Hook AL, Taylor M, Urquhart AJ, Bogatyrev SR, Langer R, Anderson DG, Davies MC, Alexander MR. Polymer surface functionalities that control human embryoid body cell adhesion revealed by high throughput surface characterization of combinatorial material microarrays. Biomaterials. 2010 Dec; 31(34):8827-38. PMID: 20832108; PMCID: PMC2992358.
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  337. Abrahamsson CK, Yang F, Park H, Brunger JM, Valonen PK, Langer R, Welter JF, Caplan AI, Guilak F, Freed LE. Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds. Tissue Eng Part A. 2010 Dec; 16(12):3709-18. PMID: 20673022; PMCID: PMC2991213.
  338. Gao W, Langer R, Farokhzad OC. Poly(ethylene glycol) with observable shedding. Angew Chem Int Ed Engl. 2010 Sep 03; 49(37):6567-71. PMID: 20677297; PMCID: PMC3131112.
  339. Elman NM, Masi BC, Cima MJ, Langer R. Electro-thermally induced structural failure actuator (ETISFA) for implantable controlled drug delivery devices based on micro-electro-mechanical-systems. Lab Chip. 2010 Oct 21; 10(20):2796-804. PMID: 20820485.
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  342. Mahon KP, Love KT, Whitehead KA, Qin J, Akinc A, Leshchiner E, Leshchiner I, Langer R, Anderson DG. Combinatorial approach to determine functional group effects on lipidoid-mediated siRNA delivery. Bioconjug Chem. 2010 Aug 18; 21(8):1448-54. PMID: 20715849; PMCID: PMC2931596.
  343. Yang F, Cho SW, Son SM, Hudson SP, Bogatyrev S, Keung L, Kohane DS, Langer R, Anderson DG. Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D. Biomacromolecules. 2010 Aug 09; 11(8):1909-14. PMID: 20614932; PMCID: PMC2946176.
  344. Tekin H, Anaya M, Brigham MD, Nauman C, Langer R, Khademhosseini A. Stimuli-responsive microwells for formation and retrieval of cell aggregates. Lab Chip. 2010 Sep 21; 10(18):2411-8. PMID: 20664846; PMCID: PMC3118411.
  345. Pritchard CD, Arnér KM, Langer RS, Ghosh FK. Retinal transplantation using surface modified poly(glycerol-co-sebacic acid) membranes. Biomaterials. 2010 Nov; 31(31):7978-84. PMID: 20656341; PMCID: PMC4059040.
  346. Kaji H, Camci-Unal G, Langer R, Khademhosseini A. Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions. Biochim Biophys Acta. 2011 Mar; 1810(3):239-50. PMID: 20655984; PMCID: PMC3026923.
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  348. Park H, Yip MC, Chertok B, Kost J, Kobler JB, Langer R, Zeitels SM. Indirect low-intensity ultrasonic stimulation for tissue engineering. J Tissue Eng. 2010 May 23; 2010:973530. PMID: 21350648; PMCID: PMC3039491.
  349. Luo Y, Kobler JB, Heaton JT, Jia X, Zeitels SM, Langer R. Injectable hyaluronic acid-dextran hydrogels and effects of implantation in ferret vocal fold. J Biomed Mater Res B Appl Biomater. 2010 May; 93(2):386-93. PMID: 20151459; PMCID: PMC4070526.
  350. Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG. Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models. PLoS One. 2010 Apr 06; 5(4):e10032. PMID: 20386609; PMCID: PMC2850367.
  351. Wang AZ, Yuet K, Zhang L, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC. ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation. Nanomedicine (Lond). 2010 Apr; 5(3):361-8. PMID: 20394530; PMCID: PMC2901911.
  352. Epstein-Barash H, Orbey G, Polat BE, Ewoldt RH, Feshitan J, Langer R, Borden MA, Kohane DS. A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery. Biomaterials. 2010 Jul; 31(19):5208-17. PMID: 20347484; PMCID: PMC3072837.
  353. Seto JE, Polat BE, Lopez RF, Blankschtein D, Langer R. Effects of ultrasound and sodium lauryl sulfate on the transdermal delivery of hydrophilic permeants: Comparative in vitro studies with full-thickness and split-thickness pig and human skin. J Control Release. 2010 Jul 01; 145(1):26-32. PMID: 20346994; PMCID: PMC2916660.
  354. Mu CJ, Lavan DA, Langer RS, Zetter BR. Self-assembled gold nanoparticle molecular probes for detecting proteolytic activity in vivo. ACS Nano. 2010 Mar 23; 4(3):1511-20. PMID: 20146506; PMCID: PMC2847389.
  355. Valencia PM, Basto PA, Zhang L, Rhee M, Langer R, Farokhzad OC, Karnik R. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano. 2010 Mar 23; 4(3):1671-9. PMID: 20166699; PMCID: PMC2923464.
  356. Fisher OZ, Khademhosseini A, Langer R, Peppas NA. Bioinspired materials for controlling stem cell fate. Acc Chem Res. 2010 Mar 16; 43(3):419-28. PMID: 20043634; PMCID: PMC2840210.
  357. Shapiro MG, Westmeyer GG, Romero PA, Szablowski JO, Küster B, Shah A, Otey CR, Langer R, Arnold FH, Jasanoff A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine. Nat Biotechnol. 2010 Mar; 28(3):264-70. PMID: 20190737; PMCID: PMC3073400.
  358. Pritchard CD, Slotkin JR, Yu D, Dai H, Lawrence MS, Bronson RT, Reynolds FM, Teng YD, Woodard EJ, Langer RS. Establishing a model spinal cord injury in the African green monkey for the preclinical evaluation of biodegradable polymer scaffolds seeded with human neural stem cells. J Neurosci Methods. 2010 May 15; 188(2):258-69. PMID: 20219534; PMCID: PMC4157751.
  359. Cheng H, Kastrup CJ, Ramanathan R, Siegwart DJ, Ma M, Bogatyrev SR, Xu Q, Whitehead KA, Langer R, Anderson DG. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery. ACS Nano. 2010 Feb 23; 4(2):625-31. PMID: 20121215; PMCID: PMC2836800.
  360. Park H, Karajanagi S, Wolak K, Aanestad J, Daheron L, Kobler JB, Lopez-Guerra G, Heaton JT, Langer RS, Zeitels SM. Three-dimensional hydrogel model using adipose-derived stem cells for vocal fold augmentation. Tissue Eng Part A. 2010 Feb; 16(2):535-43. PMID: 19728785.
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  362. Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomedicine (Lond). 2010 Feb; 5(2):269-85. PMID: 20148638; PMCID: PMC2861897.
  363. Cao Y, Langer R. Optimizing the delivery of cancer drugs that block angiogenesis. Sci Transl Med. 2010 Jan 20; 2(15):15ps3. PMID: 20371469.
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  365. Love KT, Mahon KP, Levins CG, Whitehead KA, Querbes W, Dorkin JR, Qin J, Cantley W, Qin LL, Racie T, Frank-Kamenetsky M, Yip KN, Alvarez R, Sah DW, de Fougerolles A, Fitzgerald K, Koteliansky V, Akinc A, Langer R, Anderson DG. Lipid-like materials for low-dose, in vivo gene silencing. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):1864-9. PMID: 20080679; PMCID: PMC2804742.
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  367. Alexis F, Pridgen EM, Langer R, Farokhzad OC. Nanoparticle technologies for cancer therapy. Handb Exp Pharmacol. 2010; (197):55-86. PMID: 20217526.
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  370. Dvir T, Banghart MR, Timko BP, Langer R, Kohane DS. Photo-targeted nanoparticles. Nano Lett. 2010 Jan; 10(1):250-4. PMID: 19904979; PMCID: PMC2806491.
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  373. Bettinger CJ, Bruggeman JP, Borenstein JT, Langer R. In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers. J Biomed Mater Res A. 2009 Dec 15; 91(4):1077-88. PMID: 19107786.
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  375. Hudson SP, Langer R, Fink GR, Kohane DS. Injectable in situ cross-linking hydrogels for local antifungal therapy. Biomaterials. 2010 Feb; 31(6):1444-52. PMID: 19942285; PMCID: PMC2813953.
  376. George PM, Saigal R, Lawlor MW, Moore MJ, LaVan DA, Marini RP, Selig M, Makhni M, Burdick JA, Langer R, Kohane DS. Three-dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2009 Nov; 91(2):519-27. PMID: 18985787.
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  378. Stone GW, Barzee S, Snarsky V, Santucci C, Tran B, Langer R, Zugates GT, Anderson DG, Kornbluth RS. Nanoparticle-delivered multimeric soluble CD40L DNA combined with Toll-Like Receptor agonists as a treatment for melanoma. PLoS One. 2009 Oct 08; 4(10):e7334. PMID: 19812695; PMCID: PMC2754331.
  379. Hook AL, Anderson DG, Langer R, Williams P, Davies MC, Alexander MR. High throughput methods applied in biomaterial development and discovery. Biomaterials. 2010 Jan; 31(2):187-98. PMID: 19815273.
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  380. Yang F, Cho SW, Son SM, Bogatyrev SR, Singh D, Green JJ, Mei Y, Park S, Bhang SH, Kim BS, Langer R, Anderson DG. Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3317-22. PMID: 19805054; PMCID: PMC2840438.
  381. Dang TT, Xu Q, Bratlie KM, O'Sullivan ES, Chen XY, Langer R, Anderson DG. Microfabrication of homogenous, asymmetric cell-laden hydrogel capsules. Biomaterials. 2009 Dec; 30(36):6896-902. PMID: 19800116.
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  383. Guerrini M, Zhang Z, Shriver Z, Naggi A, Masuko S, Langer R, Casu B, Linhardt RJ, Torri G, Sasisekharan R. Orthogonal analytical approaches to detect potential contaminants in heparin. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):16956-61. PMID: 19805108; PMCID: PMC2749844.
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  387. Bhang SH, Cho SW, Lim JM, Kang JM, Lee TJ, Yang HS, Song YS, Park MH, Kim HS, Yoo KJ, Jang Y, Langer R, Anderson DG, Kim BS. Locally delivered growth factor enhances the angiogenic efficacy of adipose-derived stromal cells transplanted to ischemic limbs. Stem Cells. 2009 Aug; 27(8):1976-86. PMID: 19544425.
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  389. Xu Q, Hashimoto M, Dang TT, Hoare T, Kohane DS, Whitesides GM, Langer R, Anderson DG. Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery. Small. 2009 Jul; 5(13):1575-81. PMID: 19296563; PMCID: PMC2789598.
  390. Yang F, Mei Y, Langer R, Anderson DG. High throughput optimization of stem cell microenvironments. Comb Chem High Throughput Screen. 2009 Jul; 12(6):554-61. PMID: 19601753; PMCID: PMC2748120.
  391. Nguyen DN, Kim P, Martínez-Sobrido L, Beitzel B, García-Sastre A, Langer R, Anderson DG. A novel high-throughput cell-based method for integrated quantification of type I interferons and in vitro screening of immunostimulatory RNA drug delivery. Biotechnol Bioeng. 2009 Jul 01; 103(4):664-75. PMID: 19338049; PMCID: PMC2771114.
  392. Kraehenbuehl TP, Ferreira LS, Zammaretti P, Hubbell JA, Langer R. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials. 2009 Sep; 30(26):4318-24. PMID: 19500842; PMCID: PMC4157733.
  393. Bettinger CJ, Kulig KM, Vacanti JP, Langer R, Borenstein JT. Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture. Tissue Eng Part A. 2009 Jun; 15(6):1321-9. PMID: 18847357; PMCID: PMC2789736.
  394. Lee JS, Green JJ, Love KT, Sunshine J, Langer R, Anderson DG. Gold, poly(beta-amino ester) nanoparticles for small interfering RNA delivery. Nano Lett. 2009 Jun; 9(6):2402-6. PMID: 19422265; PMCID: PMC2728206.
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  397. Yu D, Neeley WL, Pritchard CD, Slotkin JR, Woodard EJ, Langer R, Teng YD. Blockade of peroxynitrite-induced neural stem cell death in the acutely injured spinal cord by drug-releasing polymer. Stem Cells. 2009 May; 27(5):1212-22. PMID: 19418456; PMCID: PMC4070520.
  398. Lu JJ, Langer R, Chen J. A novel mechanism is involved in cationic lipid-mediated functional siRNA delivery. Mol Pharm. 2009 May-Jun; 6(3):763-71. PMID: 19292453; PMCID: PMC2688906.
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  402. Epstein-Barash H, Shichor I, Kwon AH, Hall S, Lawlor MW, Langer R, Kohane DS. Prolonged duration local anesthesia with minimal toxicity. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7125-30. PMID: 19365067; PMCID: PMC2678453.
  403. Redenti S, Neeley WL, Rompani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 2009 Jul; 30(20):3405-14. PMID: 19361860; PMCID: PMC4109162.
  404. Mei Y, Gerecht S, Taylor M, Urquhart AJ, Bogatyrev SR, Cho SW, Davies MC, Alexander MR, Langer RS, Anderson DG. Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells. Adv Mater. 2009 Jul 20; 21(27):2781-2786. PMID: 28794580.
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  406. Bettinger CJ, Bruggeman JP, Misra A, Borenstein JT, Langer R. Biocompatibility of biodegradable semiconducting melanin films for nerve tissue engineering. Biomaterials. 2009 Jun; 30(17):3050-7. PMID: 19286252; PMCID: PMC4059055.
  407. Ellenberg D, Shi J, Jain S, Chang JH, Ripps H, Brady S, Melhem ER, Lakkis F, Adamis A, Chen DF, Ellis-Behnke R, Langer RS, Strittmatter SM, Azar DT. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation. Br J Ophthalmol. 2009 Sep; 93(9):1134-40. PMID: 19286686; PMCID: PMC2850278.
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  409. Shapiro MG, Szablowski JO, Langer R, Jasanoff A. Protein nanoparticles engineered to sense kinase activity in MRI. J Am Chem Soc. 2009 Feb 25; 131(7):2484-6. PMID: 19199639; PMCID: PMC2662502.
  410. Huang YH, Bao Y, Peng W, Goldberg M, Love K, Bumcrot DA, Cole G, Langer R, Anderson DG, Sawicki JA. Claudin-3 gene silencing with siRNA suppresses ovarian tumor growth and metastasis. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3426-30. PMID: 19208807; PMCID: PMC2651300.
  411. Whitehead KA, Langer R, Anderson DG. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov. 2009 Feb; 8(2):129-38. PMID: 19180106.
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  416. Ciolino JB, Hoare TR, Iwata NG, Behlau I, Dohlman CH, Langer R, Kohane DS. A drug-eluting contact lens. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3346-52. PMID: 19136709; PMCID: PMC4657544.
  417. Yang F, Green JJ, Dinio T, Keung L, Cho SW, Park H, Langer R, Anderson DG. Gene delivery to human adult and embryonic cell-derived stem cells using biodegradable nanoparticulate polymeric vectors. Gene Ther. 2009 Apr; 16(4):533-46. PMID: 19129861; PMCID: PMC2688702.
  418. Bettinger CJ, Langer R, Borenstein JT. Engineering substrate topography at the micro- and nanoscale to control cell function. Angew Chem Int Ed Engl. 2009; 48(30):5406-15. PMID: 19492373; PMCID: PMC2834566.
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  420. Gu F, Langer R, Farokhzad OC. Formulation/preparation of functionalized nanoparticles for in vivo targeted drug delivery. Methods Mol Biol. 2009; 544:589-98. PMID: 19488725; PMCID: PMC4059054.
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  432. Cao Y, Langer R. A review of Judah Folkman's remarkable achievements in biomedicine. Proc Natl Acad Sci U S A. 2008 Sep 09; 105(36):13203-5. PMID: 18772371; PMCID: PMC2533169.
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  440. Park H, Williams R, Goldman N, Choe H, Kobler J, Lopez-Guerra G, Heaton JT, Langer R, Zeitels SM. Comparison of effects of 2 harvesting methods on fat autograft. Laryngoscope. 2008 Aug; 118(8):1493-9. PMID: 18496155.
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  446. Green JJ, Langer R, Anderson DG. A combinatorial polymer library approach yields insight into nonviral gene delivery. Acc Chem Res. 2008 Jun; 41(6):749-59. PMID: 18507402; PMCID: PMC3490629.
  447. Wright D, Rajalingam B, Karp JM, Selvarasah S, Ling Y, Yeh J, Langer R, Dokmeci MR, Khademhosseini A. Reusable, reversibly sealable parylene membranes for cell and protein patterning. J Biomed Mater Res A. 2008 May; 85(2):530-8. PMID: 17729252; PMCID: PMC2841044.
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  455. Bettinger CJ, Bruggeman JP, Borenstein JT, Langer RS. Amino alcohol-based degradable poly(ester amide) elastomers. Biomaterials. 2008 May; 29(15):2315-25. PMID: 18295329; PMCID: PMC2880180.
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  462. Sawicki JA, Anderson DG, Langer R. Nanoparticle delivery of suicide DNA for epithelial ovarian cancer therapy. Adv Exp Med Biol. 2008; 622:209-19. PMID: 18546630.
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  464. Bettinger CJ, Zhang Z, Gerecht S, Borenstein JT, Langer R. Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography. Adv Mater. 2008; 20(1):99-103. PMID: 19440248.
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  476. Hong S, Lee D, Zhang H, Zhang JQ, Resvick JN, Khademhosseini A, King MR, Langer R, Karp JM. Covalent immobilization of p-selectin enhances cell rolling. Langmuir. 2007 Nov 20; 23(24):12261-8. PMID: 17949112; PMCID: PMC2546510.
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  490. Kim GY, Tyler BM, Tupper MM, Karp JM, Langer RS, Brem H, Cima MJ. Resorbable polymer microchips releasing BCNU inhibit tumor growth in the rat 9L flank model. J Control Release. 2007 Nov 06; 123(2):172-8. PMID: 17884232.
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  494. Daniel KD, Kim GY, Vassiliou CC, Jalali-Yazdi F, Langer R, Cima MJ. Multi-reservoir device for detecting a soluble cancer biomarker. Lab Chip. 2007 Oct; 7(10):1288-93. PMID: 17896012.
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  613. Stevens MM, Marini RP, Martin I, Langer R, Prasad Shastri V. FGF-2 enhances TGF-beta1-induced periosteal chondrogenesis. J Orthop Res. 2004 Sep; 22(5):1114-9. PMID: 15304287.
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  614. Suh KY, Khademhosseini A, Yoo PJ, Langer R. Patterning and separating infected bacteria using host-parasite and virus-antibody interactions. Biomed Microdevices. 2004 Sep; 6(3):223-9. PMID: 15377832.
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  615. Haining WN, Anderson DG, Little SR, von Bergwelt-Baildon MS, Cardoso AA, Alves P, Kosmatopoulos K, Nadler LM, Langer R, Kohane DS, von Berwelt-Baildon MS. pH-triggered microparticles for peptide vaccination. J Immunol. 2004 Aug 15; 173(4):2578-85. PMID: 15294974.
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  616. Yue IC, Poff J, Cortés ME, Sinisterra RD, Faris CB, Hildgen P, Langer R, Shastri VP. A novel polymeric chlorhexidine delivery device for the treatment of periodontal disease. Biomaterials. 2004 Aug; 25(17):3743-50. PMID: 15020150.
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  617. Khademhosseini A, Suh KY, Yang JM, Eng G, Yeh J, Levenberg S, Langer R. Layer-by-layer deposition of hyaluronic acid and poly-L-lysine for patterned cell co-cultures. Biomaterials. 2004 Aug; 25(17):3583-92. PMID: 15020132.
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  618. Jia X, Colombo G, Padera R, Langer R, Kohane DS. Prolongation of sciatic nerve blockade by in situ cross-linked hyaluronic acid. Biomaterials. 2004 Aug; 25(19):4797-804. PMID: 15120526.
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  619. Khademhosseini A, Yeh J, Jon S, Eng G, Suh KY, Burdick JA, Langer R. Molded polyethylene glycol microstructures for capturing cells within microfluidic channels. Lab Chip. 2004 Oct; 4(5):425-30. PMID: 15472725.
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  620. Suh KY, Khademhosseini A, Eng G, Langer R. Single nanocrystal arrays on patterned poly(ethylene glycol) copolymer microstructures using selective wetting and drying. Langmuir. 2004 Jul 20; 20(15):6080-4. PMID: 15248685.
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  621. Marini RP, Stevens MM, Langer R, Shastri VP. Hydraulic elevation of the periosteum: a novel technique for periosteal harvest. J Invest Surg. 2004 Jul-Aug; 17(4):229-33. PMID: 15371165.
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  622. Langer RS. An audience with... Robert S. Langer [interviewed by Kenneth J. Germeshausen]. Nat Rev Drug Discov. 2004 Jul; 3(7):546. PMID: 15272496.
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  623. Khademhosseini A, Suh KY, Jon S, Eng G, Yeh J, Chen GJ, Langer R. A soft lithographic approach to fabricate patterned microfluidic channels. Anal Chem. 2004 Jul 01; 76(13):3675-81. PMID: 15228340.
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  624. Chau Y, Tan FE, Langer R. Synthesis and characterization of dextran-peptide-methotrexate conjugates for tumor targeting via mediation by matrix metalloproteinase II and matrix metalloproteinase IX. Bioconjug Chem. 2004 Jul-Aug; 15(4):931-41. PMID: 15264885.
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  625. Qi Y, Zhao G, Liu D, Shriver Z, Sundaram M, Sengupta S, Venkataraman G, Langer R, Sasisekharan R. Delivery of therapeutic levels of heparin and low-molecular-weight heparin through a pulmonary route. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9867-72. PMID: 15226520; PMCID: PMC470765.
  626. Burdick JA, Khademhosseini A, Langer R. Fabrication of gradient hydrogels using a microfluidics/photopolymerization process. Langmuir. 2004 Jun 22; 20(13):5153-6. PMID: 15986641.
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  627. Little SR, Lynn DM, Ge Q, Anderson DG, Puram SV, Chen J, Eisen HN, Langer R. Poly-beta amino ester-containing microparticles enhance the activity of nonviral genetic vaccines. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9534-9. PMID: 15210954; PMCID: PMC470709.
  628. Anderson DG, Levenberg S, Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol. 2004 Jul; 22(7):863-6. PMID: 15195101.
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  629. Richards Grayson AC, Cima MJ, Langer R. Molecular release from a polymeric microreservoir device: Influence of chemistry, polymer swelling, and loading on device performance. J Biomed Mater Res A. 2004 Jun 01; 69(3):502-12. PMID: 15127397.
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  630. Thomas TT, Kohane DS, Wang A, Langer R. Microparticulate formulations for the controlled release of interleukin-2. J Pharm Sci. 2004 May; 93(5):1100-9. PMID: 15067687.
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  631. Voskerician G, Shawgo RS, Hiltner PA, Anderson JM, Cima MJ, Langer R. In vivo inflammatory and wound healing effects of gold electrode voltammetry for MEMS micro-reservoir drug delivery device. IEEE Trans Biomed Eng. 2004 Apr; 51(4):627-35. PMID: 15072217.
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  632. Langer R, Tirrell DA. Designing materials for biology and medicine. Nature. 2004 Apr 01; 428(6982):487-92. PMID: 15057821.
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  633. Berry D, Lynn DM, Sasisekharan R, Langer R. Poly(beta-amino ester)s promote cellular uptake of heparin and cancer cell death. Chem Biol. 2004 Apr; 11(4):487-98. PMID: 15123243.
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  634. Langer R. Transdermal drug delivery: past progress, current status, and future prospects. Adv Drug Deliv Rev. 2004 Mar 27; 56(5):557-8. PMID: 15019745.
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  635. Colombo G, Langer R, Kohane DS. Effect of excipient composition on the biocompatibility of bupivacaine-containing microparticles at the sciatic nerve. J Biomed Mater Res A. 2004 Mar 15; 68(4):651-9. PMID: 14986320.
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  636. Lavik E, Langer R. Tissue engineering: current state and perspectives. Appl Microbiol Biotechnol. 2004 Jul; 65(1):1-8. PMID: 15221227.
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  637. Wang C, Ge Q, Ting D, Nguyen D, Shen HR, Chen J, Eisen HN, Heller J, Langer R, Putnam D. Molecularly engineered poly(ortho ester) microspheres for enhanced delivery of DNA vaccines. Nat Mater. 2004 Mar; 3(3):190-6. PMID: 14991022.
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  638. Stevens MM, Qanadilo HF, Langer R, Prasad Shastri V. A rapid-curing alginate gel system: utility in periosteum-derived cartilage tissue engineering. Biomaterials. 2004 Feb; 25(5):887-94. PMID: 14609677.
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  639. Suh KY, Seong J, Khademhosseini A, Laibinis PE, Langer R. A simple soft lithographic route to fabrication of poly(ethylene glycol) microstructures for protein and cell patterning. Biomaterials. 2004 Feb; 25(3):557-63. PMID: 14585705.
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  640. Shastri VP, Padera RF, Tarcha P, Langer R. A preliminary report on the biocompatibility of photopolymerizable semi-interpenetrating anhydride networks. Biomaterials. 2004 Feb; 25(4):715-21. PMID: 14607510.
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  641. Prausnitz MR, Mitragotri S, Langer R. Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov. 2004 Feb; 3(2):115-24. PMID: 15040576.
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  642. Meinel L, Karageorgiou V, Fajardo R, Snyder B, Shinde-Patil V, Zichner L, Kaplan D, Langer R, Vunjak-Novakovic G. Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng. 2004 Jan; 32(1):112-22. PMID: 14964727.
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  643. Pouliot R, Azhari R, Qanadilo HF, Mahmood TA, Triantafyllou MS, Langer R. Tissue engineering of fish skin: behavior of fish cells on poly(ethylene glycol terephthalate)/poly(butylene terephthalate) copolymers in relation to the composition of the polymer substrate as an initial step in constructing a robotic/living tissue hybrid. Tissue Eng. 2004 Jan-Feb; 10(1-2):7-21. PMID: 15009926.
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  644. Grayson AC, Voskerician G, Lynn A, Anderson JM, Cima MJ, Langer R. Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip. J Biomater Sci Polym Ed. 2004; 15(10):1281-304. PMID: 15559850.
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  645. Levenberg S, Langer R. Advances in tissue engineering. Curr Top Dev Biol. 2004; 61:113-34. PMID: 15350399.
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  646. Grovender EA, Kellogg B, Singh J, Blom D, Ploegh H, Wittrup KD, Langer RS, Ameer GA. Single-chain antibody fragment-based adsorbent for the extracorporeal removal of beta2-microglobulin. Kidney Int. 2004 Jan; 65(1):310-22. PMID: 14675065.
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  647. Seidel JO, Pei M, Gray ML, Langer R, Freed LE, Vunjak-Novakovic G. Long-term culture of tissue engineered cartilage in a perfused chamber with mechanical stimulation. Biorheology. 2004; 41(3-4):445-58. PMID: 15299276.
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  648. Yu B, Kim KH, So PT, Blankschtein D, Langer R. Evaluation of fluorescent probe surface intensities as an indicator of transdermal permeant distributions using wide-area two-photon fluorescence microscopy. J Pharm Sci. 2003 Dec; 92(12):2354-65. PMID: 14603481.
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  649. Lee H, Cusick RA, Utsunomiya H, Ma PX, Langer R, Vacanti JP. Effect of implantation site on hepatocytes heterotopically transplanted on biodegradable polymer scaffolds. Tissue Eng. 2003 Dec; 9(6):1227-32. PMID: 14670110.
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  650. Putnam D, Zelikin AN, Izumrudov VA, Langer R. Polyhistidine-PEG:DNA nanocomposites for gene delivery. Biomaterials. 2003 Nov; 24(24):4425-33. PMID: 12922153.
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  651. Richards Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat Mater. 2003 Nov; 2(11):767-72. PMID: 14619935.
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  652. Moses MA, Brem H, Langer R. Advancing the field of drug delivery: taking aim at cancer. Cancer Cell. 2003 Nov; 4(5):337-41. PMID: 14667500.
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  653. Jon S, Anderson DG, Langer R. Degradable poly(amino alcohol esters) as potential DNA vectors with low cytotoxicity. Biomacromolecules. 2003 Nov-Dec; 4(6):1759-62. PMID: 14606906.
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  654. Levenberg S, Huang NF, Lavik E, Rogers AB, Itskovitz-Eldor J, Langer R. Differentiation of human embryonic stem cells on three-dimensional polymer scaffolds. Proc Natl Acad Sci U S A. 2003 Oct 28; 100(22):12741-6. PMID: 14561891; PMCID: PMC240688.
  655. Radisic M, Yang L, Boublik J, Cohen RJ, Langer R, Freed LE, Vunjak-Novakovic G. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(2):H507-16. PMID: 14551059.
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  656. LaVan DA, McGuire T, Langer R. Small-scale systems for in vivo drug delivery. Nat Biotechnol. 2003 Oct; 21(10):1184-91. PMID: 14520404.
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  657. Kohane DS, Anderson DG, Yu C, Langer R. pH-triggered release of macromolecules from spray-dried polymethacrylate microparticles. Pharm Res. 2003 Oct; 20(10):1533-8. PMID: 14620503.
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  658. Akinc A, Anderson DG, Lynn DM, Langer R. Synthesis of poly(beta-amino ester)s optimized for highly effective gene delivery. Bioconjug Chem. 2003 Sep-Oct; 14(5):979-88. PMID: 13129402.
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  659. Shastri VP, Hildgen P, Langer R. In situ pore formation in a polymer matrix by differential polymer degradation. Biomaterials. 2003 Aug; 24(18):3133-7. PMID: 12895586.
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  660. Fu K, Harrell R, Zinski K, Um C, Jaklenec A, Frazier J, Lotan N, Burke P, Klibanov AM, Langer R. A potential approach for decreasing the burst effect of protein from PLGA microspheres. J Pharm Sci. 2003 Aug; 92(8):1582-91. PMID: 12884245.
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  661. Anderson DG, Lynn DM, Langer R. Semi-automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl. 2003 Jul 14; 42(27):3153-8. PMID: 12866105.
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  662. Wang Y, Kim YM, Langer R. In vivo degradation characteristics of poly(glycerol sebacate). J Biomed Mater Res A. 2003 Jul 01; 66(1):192-7. PMID: 12833446.
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  663. Nashat AH, Langer R. Temporal characteristics of activation, deactivation, and restimulation of signal transduction following depolarization in the pheochromocytoma cell line PC12. Mol Cell Biol. 2003 Jul; 23(14):4788-95. PMID: 12832466; PMCID: PMC162208.
  664. Kohane DS, Smith SE, Louis DN, Colombo G, Ghoroghchian P, Hunfeld NG, Berde CB, Langer R. Prolonged duration local anesthesia from tetrodotoxin-enhanced local anesthetic microspheres. Pain. 2003 Jul; 104(1-2):415-21. PMID: 12855352.
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  665. Baroli B, Shastri VP, Langer R. A method to protect sensitive molecules from a light-induced polymerizing environment. J Pharm Sci. 2003 Jun; 92(6):1186-95. PMID: 12761808.
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  666. Radisic M, Euloth M, Yang L, Langer R, Freed LE, Vunjak-Novakovic G. High-density seeding of myocyte cells for cardiac tissue engineering. Biotechnol Bioeng. 2003 May 20; 82(4):403-14. PMID: 12632397.
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  667. Akinc A, Lynn DM, Anderson DG, Langer R. Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery. J Am Chem Soc. 2003 May 07; 125(18):5316-23. PMID: 12720443.
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  668. Voskerician G, Shive MS, Shawgo RS, von Recum H, Anderson JM, Cima MJ, Langer R. Biocompatibility and biofouling of MEMS drug delivery devices. Biomaterials. 2003 May; 24(11):1959-67. PMID: 12615486.
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  669. Lahann J, Balcells M, Lu H, Rodon T, Jensen KF, Langer R. Reactive polymer coatings: a first step toward surface engineering of microfluidic devices. Anal Chem. 2003 May 01; 75(9):2117-22. PMID: 12720350.
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  670. Langer R. Where a pill won't reach. Sci Am. 2003 Apr; 288(4):50-7. PMID: 12661315.
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  671. LaVan DA, George PM, Langer R. Simple, three-dimensional microfabrication of electrodeposited structures. Angew Chem Int Ed Engl. 2003 Mar 17; 42(11):1262-5. PMID: 12645058.
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  672. Yu B, Kim KH, So PT, Blankschtein D, Langer R. Visualization of oleic acid-induced transdermal diffusion pathways using two-photon fluorescence microscopy. J Invest Dermatol. 2003 Mar; 120(3):448-55. PMID: 12603859.
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  673. Lee PJ, Langer R, Shastri VP. Novel microemulsion enhancer formulation for simultaneous transdermal delivery of hydrophilic and hydrophobic drugs. Pharm Res. 2003 Feb; 20(2):264-9. PMID: 12636166.
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  674. Lahann J, Mitragotri S, Tran TN, Kaido H, Sundaram J, Choi IS, Hoffer S, Somorjai GA, Langer R. A reversibly switching surface. Science. 2003 Jan 17; 299(5605):371-4. PMID: 12532011.
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  675. Potineni A, Lynn DM, Langer R, Amiji MM. Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. J Control Release. 2003 Jan 17; 86(2-3):223-34. PMID: 12526819.
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  676. Sundaram M, Qi Y, Shriver Z, Liu D, Zhao G, Venkataraman G, Langer R, Sasisekharan R. Rational design of low-molecular weight heparins with improved in vivo activity. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):651-6. PMID: 12525684; PMCID: PMC141051.
  677. Valente AX, Langer R, Stone HA, Edwards DA. Recent advances in the development of an inhaled insulin product. BioDrugs. 2003; 17(1):9-17. PMID: 12534317.
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  678. Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 2002 Dec; 43(12):1462-8. PMID: 12460246.
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  679. Kumar N, Langer RS, Domb AJ. Polyanhydrides: an overview. Adv Drug Deliv Rev. 2002 Oct 16; 54(7):889-910. PMID: 12384314.
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  680. Katti DS, Lakshmi S, Langer R, Laurencin CT. Toxicity, biodegradation and elimination of polyanhydrides. Adv Drug Deliv Rev. 2002 Oct 16; 54(7):933-61. PMID: 12384316.
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  681. Madry H, Padera R, Seidel J, Langer R, Freed LE, Trippel SB, Vunjak-Novakovic G. Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage. Hum Gene Ther. 2002 Sep 01; 13(13):1621-30. PMID: 12228017.
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  682. Kohane DS, Plesnila N, Thomas SS, Le D, Langer R, Moskowitz MA. Lipid-sugar particles for intracranial drug delivery: safety and biocompatibility. Brain Res. 2002 Aug 16; 946(2):206-13. PMID: 12137923.
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  683. Tang H, Blankschtein D, Langer R. Effects of low-frequency ultrasound on the transdermal permeation of mannitol: comparative studies with in vivo and in vitro skin. J Pharm Sci. 2002 Aug; 91(8):1776-94. PMID: 12115805.
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  684. Tang H, Wang CC, Blankschtein D, Langer R. An investigation of the role of cavitation in low-frequency ultrasound-mediated transdermal drug transport. Pharm Res. 2002 Aug; 19(8):1160-9. PMID: 12240942.
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  685. Tang H, Blankschtein D, Langer R. Prediction of steady-state skin permeabilities of polar and nonpolar permeants across excised pig skin based on measurements of transient diffusion: characterization of hydration effects on the skin porous pathway. J Pharm Sci. 2002 Aug; 91(8):1891-907. PMID: 12115816.
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  686. Rupnick MA, Panigrahy D, Zhang CY, Dallabrida SM, Lowell BB, Langer R, Folkman MJ. Adipose tissue mass can be regulated through the vasculature. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10730-5. PMID: 12149466; PMCID: PMC125027.
  687. Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE, Vunjak-Novakovic G. Effects of oxygen on engineered cardiac muscle. Biotechnol Bioeng. 2002 Jun 20; 78(6):617-25. PMID: 11992527.
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  688. Akinc A, Langer R. Measuring the pH environment of DNA delivered using nonviral vectors: implications for lysosomal trafficking. Biotechnol Bioeng. 2002 Jun 05; 78(5):503-8. PMID: 12115119.
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  689. Wang Y, Ameer GA, Sheppard BJ, Langer R. A tough biodegradable elastomer. Nat Biotechnol. 2002 Jun; 20(6):602-6. PMID: 12042865.
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  690. Yu B, Hean Kim K, So PT, Blankschtein D, Langer R. Topographic heterogeneity in transdermal transport revealed by high-speed two-photon microscopy: determination of representative skin sample sizes. J Invest Dermatol. 2002 Jun; 118(6):1085-8. PMID: 12060407.
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  691. Lee H, Cusick RA, Browne F, Ho Kim T, Ma PX, Utsunomiya H, Langer R, Vacanti JP. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation. 2002 May 27; 73(10):1589-93. PMID: 12042644.
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  692. Zelikin AN, Putnam D, Shastri P, Langer R, Izumrudov VA. Aliphatic ionenes as gene delivery agents: elucidation of structure-function relationship through modification of charge density and polymer length. Bioconjug Chem. 2002 May-Jun; 13(3):548-53. PMID: 12009945.
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  693. Lendlein A, Langer R. Biodegradable, elastic shape-memory polymers for potential biomedical applications. Science. 2002 May 31; 296(5573):1673-6. PMID: 11976407.
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  694. Carrier RL, Rupnick M, Langer R, Schoen FJ, Freed LE, Vunjak-Novakovic G. Perfusion improves tissue architecture of engineered cardiac muscle. Tissue Eng. 2002 Apr; 8(2):175-88. PMID: 12031108.
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  695. Levenberg S, Golub JS, Amit M, Itskovitz-Eldor J, Langer R. Endothelial cells derived from human embryonic stem cells. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4391-6. PMID: 11917100; PMCID: PMC123658.
  696. Terahara T, Mitragotri S, Kost J, Langer R. Dependence of low-frequency sonophoresis on ultrasound parameters; distance of the horn and intensity. Int J Pharm. 2002 Mar 20; 235(1-2):35-42. PMID: 11879737.
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  697. Kohane DS, Lipp M, Kinney RC, Anthony DC, Louis DN, Lotan N, Langer R. Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. J Biomed Mater Res. 2002 Mar 05; 59(3):450-9. PMID: 11774302.
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  698. Terahara T, Mitragotri S, Langer R. Porous resins as a cavitation enhancer for low-frequency sonophoresis. J Pharm Sci. 2002 Mar; 91(3):753-9. PMID: 11920760.
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  699. Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D, Langer R, Snyder EY. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):3024-9. PMID: 11867737; PMCID: PMC122466.
  700. Blunk T, Sieminski AL, Gooch KJ, Courter DL, Hollander AP, Nahir AM, Langer R, Vunjak-Novakovic G, Freed LE. Differential effects of growth factors on tissue-engineered cartilage. Tissue Eng. 2002 Feb; 8(1):73-84. PMID: 11886656.
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  701. Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R. Erodible conducting polymers for potential biomedical applications. Angew Chem Int Ed Engl. 2002 Jan 04; 41(1):141-4. PMID: 12491465.
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  702. LaVan DA, Lynn DM, Langer R. Moving smaller in drug discovery and delivery. Nat Rev Drug Discov. 2002 Jan; 1(1):77-84. PMID: 12119612.
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  703. Lavik E, Teng YD, Snyder E, Langer R. Seeding neural stem cells on scaffolds of PGA, PLA, and their copolymers. Methods Mol Biol. 2002; 198:89-97. PMID: 11951644.
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  704. Ameer GA, Mahmood TA, Langer R. A biodegradable composite scaffold for cell transplantation. J Orthop Res. 2002 Jan; 20(1):16-9. PMID: 11853084.
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  705. Elisseeff J, McIntosh W, Fu K, Blunk BT, Langer R. Controlled-release of IGF-I and TGF-beta1 in a photopolymerizing hydrogel for cartilage tissue engineering. J Orthop Res. 2001 Nov; 19(6):1098-104. PMID: 11781011.
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  706. Choi WS, Murthy GG, Edwards DA, Langer R, Klibanov AM. Inhalation delivery of proteins from ethanol suspensions. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11103-7. PMID: 11562495; PMCID: PMC58690.
  707. Ameer GA, Crumpler ET, Langer R. Cell-killing potential of a water-soluble radical initiator. Int J Cancer. 2001 Sep; 93(6):875-9. PMID: 11519051.
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  708. Lynn DM, Anderson DG, Putnam D, Langer R. Accelerated discovery of synthetic transfection vectors: parallel synthesis and screening of a degradable polymer library. J Am Chem Soc. 2001 Aug 22; 123(33):8155-6. PMID: 11506588.
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  709. Lahann J, Höcker H, Langer R. Synthesis of Amino[2.2]paracyclophanes-Beneficial Monomers for Bioactive Coating of Medical Implant Materials. Angew Chem Int Ed Engl. 2001 Aug 17; 40(16):2947. PMID: 12203613.
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  710. Perez C, Sanchez A, Putnam D, Ting D, Langer R, Alonso MJ. Poly(lactic acid)-poly(ethylene glycol) nanoparticles as new carriers for the delivery of plasmid DNA. J Control Release. 2001 Jul 10; 75(1-2):211-24. PMID: 11451511.
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  711. Langer R. Drug delivery. Drugs on target. Science. 2001 Jul 06; 293(5527):58-9. PMID: 11441170.
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  712. Yu B, Dong CY, So PT, Blankschtein D, Langer R. In vitro visualization and quantification of oleic acid induced changes in transdermal transport using two-photon fluorescence microscopy. J Invest Dermatol. 2001 Jul; 117(1):16-25. PMID: 11442745.
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  713. Lynn DM, Amiji MM, Langer R. pH-Responsive Polymer Microspheres: Rapid Release of Encapsulated Material within the Range of Intracellular pH Financial support was provided by the NSF (Cooperative Agreement No. ECC9843342 to the MIT Biotechnology Process Engineering Center), the NIH (GM26698), and the Department of the Army (Cooperative Agreement DAMD 17-99-2-9-001 to the Center for Innovative Minimally Invasive Therapy). D.M.L. wishes to thank the NIH for a Postdoctoral Fellowship (NRSA Fellowship No. 1 F32 GM20227-01). Scanning electron microscopy and confocal microscopy images were acquired by William Fowle at the Northeastern University Center for Electron Microscopy. Dr. David Putnam, David Ting, and Tommy Thomas are thanked for helpful discussions. Angew Chem Int Ed Engl. 2001 May 04; 40(9):1707-1710. PMID: 11353487.
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  714. Tang H, Mitragotri S, Blankschtein D, Langer R. Theoretical description of transdermal transport of hydrophilic permeants: application to low-frequency sonophoresis. J Pharm Sci. 2001 May; 90(5):545-68. PMID: 11288100.
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  715. Lavik EB, Hrkach JS, Lotan N, Nazarov R, Langer R. A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications. J Biomed Mater Res. 2001 May 01; 58(3):291-4. PMID: 11319743.
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  716. Martin I, Shastri VP, Padera RF, Yang J, Mackay AJ, Langer R, Vunjak-Novakovic G, Freed LE. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 2001 May; 55(2):229-35. PMID: 11255174.
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  717. Lesniak MS, Langer R, Brem H. Drug delivery to tumors of the central nervous system. Curr Neurol Neurosci Rep. 2001 May; 1(3):210-6. PMID: 11898520.
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  718. Ameer GA, Grovender EA, Ploegh H, Ting D, Owen WF, Rupnick M, Langer R. A novel immunoadsorption device for removing beta2-microglobulin from whole blood. Kidney Int. 2001 Apr; 59(4):1544-50. PMID: 11260419.
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  719. Niklason LE, Abbott W, Gao J, Klagges B, Hirschi KK, Ulubayram K, Conroy N, Jones R, Vasanawala A, Sanzgiri S, Langer R. Morphologic and mechanical characteristics of engineered bovine arteries. J Vasc Surg. 2001 Mar; 33(3):628-38. PMID: 11241137.
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  722. Lahann J, Höcker H, Langer R. Synthesis of Amino Angew Chem Int Ed Engl. 2001 Feb 16; 40(4):726-728. PMID: 11241604.
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  723. Niklason LE, Langer R. Prospects for organ and tissue replacement. JAMA. 2001 Feb 07; 285(5):573-6. PMID: 11176861.
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  724. Hirosue S, Müller BG, Mulligan RC, Langer R. Plasmid DNA encapsulation and release from solvent diffusion nanospheres. J Control Release. 2001 Jan 29; 70(1-2):231-42. PMID: 11166423.
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  725. Putnam D, Gentry CA, Pack DW, Langer R. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1200-5. PMID: 11158617; PMCID: PMC14732.
  726. Papadaki M, Bursac N, Langer R, Merok J, Vunjak-Novakovic G, Freed LE. Tissue engineering of functional cardiac muscle: molecular, structural, and electrophysiological studies. Am J Physiol Heart Circ Physiol. 2001 Jan; 280(1):H168-78. PMID: 11123231.
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  727. Papadaki M, Mahmood T, Gupta P, Claase MB, Grijpma DW, Riesle J, van Blitterswijk CA, Langer R. The different behaviors of skeletal muscle cells and chondrocytes on PEGT/PBT block copolymers are related to the surface properties of the substrate. J Biomed Mater Res. 2001 Jan; 54(1):47-58. PMID: 11077402.
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  728. Schaefer D, Martin I, Shastri P, Padera RF, Langer R, Freed LE, Vunjak-Novakovic G. In vitro generation of osteochondral composites. Biomaterials. 2000 Dec; 21(24):2599-606. PMID: 11071609.
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  729. Kohane DS, Lipp M, Kinney RC, Lotan N, Langer R. Sciatic nerve blockade with lipid-protein-sugar particles containing bupivacaine. Pharm Res. 2000 Oct; 17(10):1243-9. PMID: 11145230.
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  730. Lu L, Peter SJ, Lyman MD, Lai HL, Leite SM, Tamada JA, Uyama S, Vacanti JP, Langer R, Mikos AG. In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams. Biomaterials. 2000 Sep; 21(18):1837-45. PMID: 10919687.
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  731. Santini JT, Richards AC, Scheidt RA, Cima MJ, Langer RS. Microchip technology in drug delivery. Ann Med. 2000 Sep; 32(6):377-9. PMID: 11028682.
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  732. Elisseeff J, McIntosh W, Anseth K, Riley S, Ragan P, Langer R. Photoencapsulation of chondrocytes in poly(ethylene oxide)-based semi-interpenetrating networks. J Biomed Mater Res. 2000 Aug; 51(2):164-71. PMID: 10825215.
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  733. Lu L, Peter SJ, Lyman MD, Lai HL, Leite SM, Tamada JA, Vacanti JP, Langer R, Mikos AG. In vitro degradation of porous poly(L-lactic acid) foams. Biomaterials. 2000 Aug; 21(15):1595-605. PMID: 10885732.
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  734. Mitragotri S, Ray D, Farrell J, Tang H, Yu B, Kost J, Blankschtein D, Langer R. Synergistic effect of low-frequency ultrasound and sodium lauryl sulfate on transdermal transport. J Pharm Sci. 2000 Jul; 89(7):892-900. PMID: 10861590.
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  735. Mitragotri S, Coleman M, Kost J, Langer R. Transdermal extraction of analytes using low-frequency ultrasound. Pharm Res. 2000 Apr; 17(4):466-70. PMID: 10870992.
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  736. Shastri VP, Martin I, Langer R. Macroporous polymer foams by hydrocarbon templating. Proc Natl Acad Sci U S A. 2000 Feb 29; 97(5):1970-5. PMID: 10696111; PMCID: PMC15738.
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  739. Pack DW, Putnam D, Langer R. Design of imidazole-containing endosomolytic biopolymers for gene delivery. Biotechnol Bioeng. 2000 Jan 20; 67(2):217-23. PMID: 10592519.
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  741. Chen T, Langer R, Weaver JC. An in vitro system for measuring the transdermal voltage and molecular flux across the skin in real time. Methods Mol Med. 2000; 37:407-36. PMID: 21445757.
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  742. Fu K, Klibanov AM, Langer R. Protein stability in controlled-release systems. Nat Biotechnol. 2000 Jan; 18(1):24-5. PMID: 10625383.
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  743. Fu K, Pack DW, Klibanov AM, Langer R. Visual evidence of acidic environment within degrading poly(lactic-co-glycolic acid) (PLGA) microspheres. Pharm Res. 2000 Jan; 17(1):100-6. PMID: 10714616.
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  744. Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE, Vunjak-Novakovic G. Modulation of the mechanical properties of tissue engineered cartilage. Biorheology. 2000; 37(1-2):141-7. PMID: 10912186.
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  745. Patel N, Bhandari R, Shakesheff KM, Cannizzaro SM, Davies MC, Langer R, Roberts CJ, Tendler SJ, Williams PM. Printing patterns of biospecifically-adsorbed protein. J Biomater Sci Polym Ed. 2000; 11(3):319-31. PMID: 10841282.
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  746. Langer R. Tissue engineering. Mol Ther. 2000 Jan; 1(1):12-5. PMID: 10933907.
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  747. Martin I, Vunjak-Novakovic G, Yang J, Langer R, Freed LE. Mammalian chondrocytes expanded in the presence of fibroblast growth factor 2 maintain the ability to differentiate and regenerate three-dimensional cartilaginous tissue. Exp Cell Res. 1999 Dec 15; 253(2):681-8. PMID: 10585291.
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  748. Shum-Tim D, Stock U, Hrkach J, Shinoka T, Lien J, Moses MA, Stamp A, Taylor G, Moran AM, Landis W, Langer R, Vacanti JP, Mayer JE. Tissue engineering of autologous aorta using a new biodegradable polymer. Ann Thorac Surg. 1999 Dec; 68(6):2298-304; discussion 2305. PMID: 10617020.
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  749. Tobío M, Schwendeman SP, Guo Y, McIver J, Langer R, Alonso MJ. Improved immunogenicity of a core-coated tetanus toxoid delivery system. Vaccine. 1999 Nov 12; 18(7-8):618-22. PMID: 10547420.
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  750. Langer R. Selected advances in drug delivery and tissue engineering. J Control Release. 1999 Nov 01; 62(1-2):7-11. PMID: 10518629.
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  751. Vanbever R, Mintzes JD, Wang J, Nice J, Chen D, Batycky R, Langer R, Edwards DA. Formulation and physical characterization of large porous particles for inhalation. Pharm Res. 1999 Nov; 16(11):1735-42. PMID: 10571280.
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  752. Zewert TE, Pliquett UF, Vanbever R, Langer R, Weaver JC. Creation of transdermal pathways for macromolecule transport by skin electroporation and a low toxicity, pathway-enlarging molecule. Bioelectrochem Bioenerg. 1999 Oct; 49(1):11-20. PMID: 10619443.
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  753. Carrier RL, Papadaki M, Rupnick M, Schoen FJ, Bursac N, Langer R, Freed LE, Vunjak-Novakovic G. Cardiac tissue engineering: cell seeding, cultivation parameters, and tissue construct characterization. Biotechnol Bioeng. 1999 Sep 05; 64(5):580-9. PMID: 10404238.
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  754. Mitragotri S, Johnson ME, Blankschtein D, Langer R. An analysis of the size selectivity of solute partitioning, diffusion, and permeation across lipid bilayers. Biophys J. 1999 Sep; 77(3):1268-83. PMID: 10465741; PMCID: PMC1300418.
  755. Elisseeff J, Anseth K, Sims D, McIntosh W, Randolph M, Yaremchuk M, Langer R. Transdermal photopolymerization of poly(ethylene oxide)-based injectable hydrogels for tissue-engineered cartilage. Plast Reconstr Surg. 1999 Sep; 104(4):1014-22. PMID: 10654741.
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  756. Dillow AK, Dehghani F, Hrkach JS, Foster NR, Langer R. Bacterial inactivation by using near- and supercritical carbon dioxide. Proc Natl Acad Sci U S A. 1999 Aug 31; 96(18):10344-8. PMID: 10468610; PMCID: PMC17890.
  757. Vacanti JP, Langer R. Tissue engineering: the design and fabrication of living replacement devices for surgical reconstruction and transplantation. Lancet. 1999 Jul; 354 Suppl 1:SI32-4. PMID: 10437854.
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  758. Ameer GA, Raghavan S, Sasisekharan R, Harmon W, Cooney CL, Langer R. Regional heparinization via simultaneous separation and reaction in a novel Taylor-Couette flow device. Biotechnol Bioeng. 1999 Jun 05; 63(5):618-24. PMID: 10397818.
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  759. Stading M, Langer R. Mechanical shear properties of cell-polymer cartilage constructs. Tissue Eng. 1999 Jun; 5(3):241-50. PMID: 10434071.
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  760. Sinisterra RD, Shastri VP, Najjar R, Langer R. Encapsulation and release of rhodium(II) citrate and its association complex with hydroxypropyl-beta-cyclodextrin from biodegradable polymer microspheres. J Pharm Sci. 1999 May; 88(5):574-6. PMID: 10229652.
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  761. Zelikin A, Shastri VR, Langer R. Facile Synthesis of 3-Alkylpyrroles. J Org Chem. 1999 Apr 30; 64(9):3379-3380. PMID: 11674451.
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  762. Niklason LE, Gao J, Abbott WM, Hirschi KK, Houser S, Marini R, Langer R. Functional arteries grown in vitro. Science. 1999 Apr 16; 284(5413):489-93. PMID: 10205057.
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  763. Ben-Jebria A, Chen D, Eskew ML, Vanbever R, Langer R, Edwards DA. Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs. Pharm Res. 1999 Apr; 16(4):555-61. PMID: 10227712.
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  764. Langer RS, Vacanti JP. Tissue engineering: the challenges ahead. Sci Am. 1999 Apr; 280(4):86-9. PMID: 10201120.
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  765. Langer RS. An interview with a distinguished pharmaceutical scientist: Robert S. Langer. Pharm Res. 1999 Apr; 16(4):475-7. PMID: 10227699.
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  767. Moses MA, Wiederschain D, Wu I, Fernandez CA, Ghazizadeh V, Lane WS, Flynn E, Sytkowski A, Tao T, Langer R. Troponin I is present in human cartilage and inhibits angiogenesis. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2645-50. PMID: 10077564; PMCID: PMC15822.
  768. Ameer GA, Harmon W, Sasisekharan R, Langer R. Investigation of a whole blood fluidized bed Taylor-Couette flow device for enzymatic heparin neutralization. Biotechnol Bioeng. 1999 Mar 05; 62(5):602-8. PMID: 10099569.
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  769. Ameer GA, Barabino G, Sasisekharan R, Harmon W, Cooney CL, Langer R. Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2350-5. PMID: 10051645; PMCID: PMC26787.
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  771. Chen T, Langer R, Weaver JC. Charged microbeads are not transported across the human stratum corneum in vitro by short high-voltage pulses. Bioelectrochem Bioenerg. 1999 Feb; 48(1):181-92. PMID: 10228586.
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  772. Anseth KS, Shastri VR, Langer R. Photopolymerizable degradable polyanhydrides with osteocompatibility. Nat Biotechnol. 1999 Feb; 17(2):156-9. PMID: 10052351.
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  773. Kohane DS, Kuang Y, Lu NT, Langer R, Strichartz GR, Berde CB. Vanilloid receptor agonists potentiate the in vivo local anesthetic activity of percutaneously injected site 1 sodium channel blockers. Anesthesiology. 1999 Feb; 90(2):524-34. PMID: 9952161.
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  774. Santini JT, Cima MJ, Langer R. A controlled-release microchip. Nature. 1999 Jan 28; 397(6717):335-8. PMID: 9988626.
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  775. Vunjak-Novakovic G, Martin I, Obradovic B, Treppo S, Grodzinsky AJ, Langer R, Freed LE. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage. J Orthop Res. 1999 Jan; 17(1):130-8. PMID: 10073657.
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  776. Ando S, Putnam D, Pack DW, Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J Pharm Sci. 1999 Jan; 88(1):126-30. PMID: 9874713.
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  777. Caponetti G, Hrkach JS, Kriwet B, Poh M, Lotan N, Colombo P, Langer R. Microparticles of novel branched copolymers of lactic acid and amino acids: preparation and characterization. J Pharm Sci. 1999 Jan; 88(1):136-41. PMID: 9874715.
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  778. Gao J, Niklason L, Langer R. Surface hydrolysis of poly(glycolic acid) meshes increases the seeding density of vascular smooth muscle cells. J Biomed Mater Res. 1998 Dec 05; 42(3):417-24. PMID: 9788505.
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  779. Riesle J, Hollander AP, Langer R, Freed LE, Vunjak-Novakovic G. Collagen in tissue-engineered cartilage: types, structure, and crosslinks. J Cell Biochem. 1998 Dec 01; 71(3):313-27. PMID: 9831069.
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  780. Uhrich KE, Ibim SE, Larrier DR, Langer R, Laurencin CT. Chemical changes during in vivo degradation of poly(anhydride-imide) matrices. Biomaterials. 1998 Nov; 19(22):2045-50. PMID: 9870755.
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  781. Chen T, Segall EM, Langer R, Weaver JC. Skin electroporation: rapid measurements of the transdermal voltage and flux of four fluorescent molecules show a transition to large fluxes near 50 V. J Pharm Sci. 1998 Nov; 87(11):1368-74. PMID: 9811492.
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  782. Patel N, Padera R, Sanders GH, Cannizzaro SM, Davies MC, Langer R, Roberts CJ, Tendler SJ, Williams PM, Shakesheff KM. Spatially controlled cell engineering on biodegradable polymer surfaces. FASEB J. 1998 Nov; 12(14):1447-54. PMID: 9806753.
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  783. Hadlock T, Elisseeff J, Langer R, Vacanti J, Cheney M. A tissue-engineered conduit for peripheral nerve repair. Arch Otolaryngol Head Neck Surg. 1998 Oct; 124(10):1081-6. PMID: 9776185.
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  784. Marler JJ, Upton J, Langer R, Vacanti JP. Transplantation of cells in matrices for tissue regeneration. Adv Drug Deliv Rev. 1998 08 03; 33(1-2):165-182. PMID: 10837658.
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  785. Chen T, Langer R, Weaver JC. Skin electroporation causes molecular transport across the stratum corneum through localized transport regions. J Investig Dermatol Symp Proc. 1998 Aug; 3(2):159-65. PMID: 9734832.
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  786. Edwards DA, Ben-Jebria A, Langer R. Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol (1985). 1998 Aug; 85(2):379-85. PMID: 9688708.
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  787. Pollok JM, Kluth D, Cusick RA, Lee H, Utsunomiya H, Ma PX, Langer R, Broelsch CE, Vacanti JP. Formation of spheroidal aggregates of hepatocytes on biodegradable polymers under continuous-flow bioreactor conditions. Eur J Pediatr Surg. 1998 Aug; 8(4):195-9. PMID: 9783140.
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  788. Kohane DS, Yieh J, Lu NT, Langer R, Strichartz GR, Berde CB. A re-examination of tetrodotoxin for prolonged duration local anesthesia. Anesthesiology. 1998 Jul; 89(1):119-31. PMID: 9667302.
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  789. Cannizzaro SM, Padera RF, Langer R, Rogers RA, Black FE, Davies MC, Tendler SJ, Shakesheff KM. A novel biotinylated degradable polymer for cell-interactive applications. Biotechnol Bioeng. 1998 Jun 05; 58(5):529-35. PMID: 10099289.
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  790. Schwendeman SP, Tobío M, Joworowicz M, Alonso MJ, Langer R. New strategies for the microencapsulation of tetanus vaccine. J Microencapsul. 1998 May-Jun; 15(3):299-318. PMID: 9608394.
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  791. Ibim SM, Uhrich KE, Bronson R, El-Amin SF, Langer RS, Laurencin CT. Poly(anhydride-co-imides): in vivo biocompatibility in a rat model. Biomaterials. 1998 May; 19(10):941-51. PMID: 9690836.
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  794. Vunjak-Novakovic G, Obradovic B, Martin I, Bursac PM, Langer R, Freed LE. Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol Prog. 1998 Mar-Apr; 14(2):193-202. PMID: 9548769.
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  795. Costantino HR, Schwendeman SP, Langer R, Klibanov AM. Deterioration of lyophilized pharmaceutical proteins. Biochemistry (Mosc). 1998 Mar; 63(3):357-63. PMID: 9526132.
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  796. Shinoka T, Shum-Tim D, Ma PX, Tanel RE, Isogai N, Langer R, Vacanti JP, Mayer JE. Creation of viable pulmonary artery autografts through tissue engineering. J Thorac Cardiovasc Surg. 1998 Mar; 115(3):536-45; discussion 545-6. PMID: 9535439.
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  797. Evora C, Soriano I, Rogers RA, Shakesheff KN, Hanes J, Langer R. Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: the effect of 1,2-dipalmitoylphosphatidylcholine. J Control Release. 1998 Feb 12; 51(2-3):143-52. PMID: 9685911.
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  799. Ibim SE, Uhrich KE, Attawia M, Shastri VR, El-Amin SF, Bronson R, Langer R, Laurencin CT. Preliminary in vivo report on the osteocompatibility of poly(anhydride-co-imides) evaluated in a tibial model. J Biomed Mater Res. 1998; 43(4):374-9. PMID: 9855196.
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  803. Mooney DJ, Sano K, Kaufmann PM, Majahod K, Schloo B, Vacanti JP, Langer R. Long-term engraftment of hepatocytes transplanted on biodegradable polymer sponges. J Biomed Mater Res. 1997 Dec 05; 37(3):413-20. PMID: 9368146.
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  806. Shinoka T, Shum-Tim D, Ma PX, Tanel RE, Langer R, Vacanti JP, Mayer JE. Tissue-engineered heart valve leaflets: does cell origin affect outcome? Circulation. 1997 Nov 04; 96(9 Suppl):II-102-7. PMID: 9386083.
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  807. Gupta RK, Alroy J, Alonso MJ, Langer R, Siber GR. Chronic local tissue reactions, long-term immunogenicity and immunologic priming of mice and guinea pigs to tetanus toxoid encapsulated in biodegradable polymer microspheres composed of poly lactide-co-glycolide polymers. Vaccine. 1997 Nov; 15(16):1716-23. PMID: 9364673.
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  808. Cook AD, Pajvani UB, Hrkach JS, Cannizzaro SM, Langer R. Colorimetric analysis of surface reactive amino groups on poly(lactic acid-co-lysine):poly(lactic acid) blends. Biomaterials. 1997 Nov; 18(21):1417-24. PMID: 9375843.
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  811. Schmidt CE, Shastri VR, Vacanti JP, Langer R. Stimulation of neurite outgrowth using an electrically conducting polymer. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):8948-53. PMID: 9256415; PMCID: PMC22977.
  812. Chiba M, Hanes J, Langer R. Controlled protein delivery from biodegradable tyrosine-containing poly(anhydride-co-imide) microspheres. Biomaterials. 1997 Jul; 18(13):893-901. PMID: 9199758.
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  815. Cook AD, Hrkach JS, Gao NN, Johnson IM, Pajvani UB, Cannizzaro SM, Langer R. Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial. J Biomed Mater Res. 1997 Jun 15; 35(4):513-23. PMID: 9189829.
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  816. Chen H, Langer R. Magnetically-responsive polymerized liposomes as potential oral delivery vehicles. Pharm Res. 1997 Apr; 14(4):537-40. PMID: 9144746.
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  817. Ernst S, Garro OA, Winkler S, Venkataraman G, Langer R, Cooney CL, Sasisekharan R. Process simulation for recombinant protein production: cost estimation and sensitivity analysis for heparinase I expressed in Escherichia coli. Biotechnol Bioeng. 1997 Mar 20; 53(6):575-82. PMID: 18634058.
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  819. Costantino HR, Griebenow K, Langer R, Klibanov AM. On the pH memory of lyophilized compounds containing protein functional groups. Biotechnol Bioeng. 1997 Feb 05; 53(3):345-8. PMID: 18633990.
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  820. Cusick RA, Lee H, Sano K, Pollok JM, Utsunomiya H, Ma PX, Langer R, Vacanti JP. The effect of donor and recipient age on engraftment of tissue-engineered liver. J Pediatr Surg. 1997 Feb; 32(2):357-60. PMID: 9044153.
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  821. Kim TH, Lee HM, Utsonomiya H, Ma P, Langer R, Schmidt EV, Vacanti JP. Enhanced survival of transgenic hepatocytes expressing hepatocyte growth factor in hepatocyte tissue engineering. Transplant Proc. 1997 Feb-Mar; 29(1-2):858-60. PMID: 9123555.
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  823. Hrkach JS, Peracchia MT, Domb A, Lotan N, Langer R. Nanotechnology for biomaterials engineering: structural characterization of amphiphilic polymeric nanoparticles by 1H NMR spectroscopy. Biomaterials. 1997 Jan; 18(1):27-30. PMID: 9003893.
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  824. Mäder K, Bacic G, Domb A, Elmalak O, Langer R, Swartz HM. Noninvasive in vivo monitoring of drug release and polymer erosion from biodegradable polymers by EPR spectroscopy and NMR imaging. J Pharm Sci. 1997 Jan; 86(1):126-34. PMID: 9002472.
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  825. Prausnitz MR, Gimm JA, Guy RH, Langer R, Weaver JC, Cullander C. Imaging regions of transport across human stratum corneum during high-voltage and low-voltage exposures. J Pharm Sci. 1996 Dec; 85(12):1363-70. PMID: 8961154.
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  826. Brown LR, Edelman ER, Fischel-Ghodsian F, Langer R. Characterization of glucose-mediated insulin release from implantable polymers. J Pharm Sci. 1996 Dec; 85(12):1341-5. PMID: 8961150.
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  827. Costantino HR, Schwendeman SP, Griebenow K, Klibanov AM, Langer R. The secondary structure and aggregation of lyophilized tetanus toxoid. J Pharm Sci. 1996 Dec; 85(12):1290-3. PMID: 8961141.
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  828. Shinoka T, Ma PX, Shum-Tim D, Breuer CK, Cusick RA, Zund G, Langer R, Vacanti JP, Mayer JE. Tissue-engineered heart valves. Autologous valve leaflet replacement study in a lamb model. Circulation. 1996 Nov 01; 94(9 Suppl):II164-8. PMID: 8901739.
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  829. Johnson ME, Berk DA, Blankschtein D, Golan DE, Jain RK, Langer RS. Lateral diffusion of small compounds in human stratum corneum and model lipid bilayer systems. Biophys J. 1996 Nov; 71(5):2656-68. PMID: 8913603; PMCID: PMC1233752.
  830. Chen H, Torchilin V, Langer R. Lectin-bearing polymerized liposomes as potential oral vaccine carriers. Pharm Res. 1996 Sep; 13(9):1378-83. PMID: 8893278.
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  831. Godavarti R, Davis M, Venkataraman G, Cooney C, Langer R, Sasisekharan R. Heparinase III from Flavobacterium heparinum: cloning and recombinant expression in Escherichia coli. Biochem Biophys Res Commun. 1996 Aug 23; 225(3):751-8. PMID: 8780685.
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  833. Langer R. Controlled release of a therapeutic protein. Nat Med. 1996 Jul; 2(7):742-3. PMID: 8673913.
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  834. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials. 1996 Jul; 17(14):1417-22. PMID: 8830969.
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  835. Breuer CK, Shin'oka T, Tanel RE, Zund G, Mooney DJ, Ma PX, Miura T, Colan S, Langer R, Mayer JE, Vacanti JP. Tissue engineering lamb heart valve leaflets. Biotechnol Bioeng. 1996 Jun 05; 50(5):562-7. PMID: 18627019.
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  836. Curley J, Castillo J, Hotz J, Uezono M, Hernandez S, Lim JO, Tigner J, Chasin M, Langer R, Berde C. Prolonged regional nerve blockade. Injectable biodegradable bupivacaine/polyester microspheres. Anesthesiology. 1996 Jun; 84(6):1401-10. PMID: 8669682.
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  837. Sanchez A, Gupta RK, Alonso MJ, Siber GR, Langer R. Pulsed controlled-released system for potential use in vaccine delivery. J Pharm Sci. 1996 Jun; 85(6):547-52. PMID: 8773947.
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  838. Sano K, Cusick RA, Lee H, Pollok JM, Kaufmann PM, Uyama S, Mooney D, Langer R, Vacanti JP. Regenerative signals for heterotopic hepatocyte transplantation. Transplant Proc. 1996 Jun; 28(3):1857-8. PMID: 8658917.
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  839. Godavarti R, Cooney CL, Langer R, Sasisekharan R. Heparinase I from Flavobacterium heparinum. Identification of a critical histidine residue essential for catalysis as probed by chemical modification and site-directed mutagenesis. Biochemistry. 1996 May 28; 35(21):6846-52. PMID: 8639636.
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  840. Mooney DJ, Kaufmann PM, Sano K, Schwendeman SP, Majahod K, Schloo B, Vacanti JP, Langer R. Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes. Biotechnol Bioeng. 1996 May 20; 50(4):422-9. PMID: 18626991.
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  841. Attawia MA, Uhrich KE, Botchwey E, Langer R, Laurencin CT. In vitro bone biocompatibility of poly (anhydride-co-imides) containing pyromellitylimidoalanine. J Orthop Res. 1996 May; 14(3):445-54. PMID: 8676258.
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  842. Ernst S, Venkataraman G, Winkler S, Godavarti R, Langer R, Cooney CL, Sasisekharan R. Expression in Escherichia coli, purification and characterization of heparinase I from Flavobacterium heparinum. Biochem J. 1996 Apr 15; 315 ( Pt 2):589-97. PMID: 8615834; PMCID: PMC1217237.
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  844. Moses MA, Marikovsky M, Harper JW, Vogt P, Eriksson E, Klagsbrun M, Langer R. Temporal study of the activity of matrix metalloproteinases and their endogenous inhibitors during wound healing. J Cell Biochem. 1996 Mar 01; 60(3):379-86. PMID: 8867813.
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  845. Mitragotri S, Blankschtein D, Langer R. Transdermal drug delivery using low-frequency sonophoresis. Pharm Res. 1996 Mar; 13(3):411-20. PMID: 8692734.
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  846. Sasisekharan R, Venkataraman G, Godavarti R, Ernst S, Cooney CL, Langer R. Heparinase I from Flavobacterium heparinum. Mapping and characterization of the heparin binding domain. J Biol Chem. 1996 Feb 09; 271(6):3124-31. PMID: 8621711.
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  847. Venkataraman G, Sasisekharan V, Herr AB, Ornitz DM, Waksman G, Cooney CL, Langer R, Sasisekharan R. Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation. Proc Natl Acad Sci U S A. 1996 Jan 23; 93(2):845-50. PMID: 8570646; PMCID: PMC40145.
  848. Pliquett UF, Zewert TE, Chen T, Langer R, Weaver JC. Imaging of fluorescent molecule and small ion transport through human stratum corneum during high voltage pulsing: localized transport regions are involved. Biophys Chem. 1996 Jan 16; 58(1-2):185-204. PMID: 8679918.
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  849. Mooney DJ, Mazzoni CL, Breuer C, McNamara K, Hern D, Vacanti JP, Langer R. Stabilized polyglycolic acid fibre-based tubes for tissue engineering. Biomaterials. 1996 Jan; 17(2):115-24. PMID: 8624388.
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  850. Schwendeman SP, Costantino HR, Gupta RK, Tobio M, Chang AC, Alonso MJ, Siber GR, Langer R. Strategies for stabilising tetanus toxoid towards the development of a single-dose tetanus vaccine. Dev Biol Stand. 1996; 87:293-306. PMID: 8854030.
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  851. Yaszemski MJ, Payne RG, Hayes WC, Langer R, Mikos AG. Evolution of bone transplantation: molecular, cellular and tissue strategies to engineer human bone. Biomaterials. 1996 Jan; 17(2):175-85. PMID: 8624394.
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  852. Ma PX, Schloo B, Mooney D, Langer R. Development of biomechanical properties and morphogenesis of in vitro tissue engineered cartilage. J Biomed Mater Res. 1995 Dec; 29(12):1587-95. PMID: 8600149.
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  853. Shinoka T, Breuer CK, Tanel RE, Zund G, Miura T, Ma PX, Langer R, Vacanti JP, Mayer JE. Tissue engineering heart valves: valve leaflet replacement study in a lamb model. Ann Thorac Surg. 1995 Dec; 60(6 Suppl):S513-6. PMID: 8604922.
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  855. Costantino HR, Griebenow K, Mishra P, Langer R, Klibanov AM. Fourier-transform infrared spectroscopic investigation of protein stability in the lyophilized form. Biochim Biophys Acta. 1995 Nov 15; 1253(1):69-74. PMID: 7492602.
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  857. Pliquett U, Langer R, Weaver JC. Changes in the passive electrical properties of human stratum corneum due to electroporation. Biochim Biophys Acta. 1995 Nov 01; 1239(2):111-21. PMID: 7488616.
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  858. Prausnitz MR, Edelman ER, Gimm JA, Langer R, Weaver JC. Transdermal delivery of heparin by skin electroporation. Biotechnology (N Y). 1995 Nov; 13(11):1205-9. PMID: 9636293.
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  859. Shefer SD, Rosenberger V, Vahanian G, Wong WT, Langer R. Implantable hollow fiber bioreactor as a potential treatment for hypercholesterolemia: characterization of the catalytic unit. Biotechnol Bioeng. 1995 Oct 05; 48(1):36-41. PMID: 18623458.
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  860. Attawia MA, Uhrich KE, Botchwey E, Fan M, Langer R, Laurencin CT. Cytotoxicity testing of poly(anhydride-co-imides) for orthopedic applications. J Biomed Mater Res. 1995 Oct; 29(10):1233-40. PMID: 8557725.
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  861. Gref R, Domb A, Quellec P, Blunk T, Müller RH, Verbavatz JM, Langer R. The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres. Adv Drug Deliv Rev. 1995 Sep; 16(2-3):215-233. PMID: 25170183.
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  862. Johnson ME, Blankschtein D, Langer R. Permeation of steroids through human skin. J Pharm Sci. 1995 Sep; 84(9):1144-6. PMID: 8537898.
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  866. Zewert TE, Pliquett UF, Langer R, Weaver JC. Transdermal transport of DNA antisense oligonucleotides by electroporation. Biochem Biophys Res Commun. 1995 Jul 17; 212(2):286-92. PMID: 7626040.
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  867. Venkataraman G, Sasisekharan V, Cooney CL, Langer R, Sasisekharan R. Complex flexibility of the transforming growth factor beta superfamily. Proc Natl Acad Sci U S A. 1995 Jun 06; 92(12):5406-10. PMID: 7777520; PMCID: PMC41703.
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  869. Mooney DJ, Langer R, Ingber DE. Cytoskeletal filament assembly and the control of cell spreading and function by extracellular matrix. J Cell Sci. 1995 Jun; 108 ( Pt 6):2311-20. PMID: 7673351.
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  871. Wake MC, Mikos AG, Sarakinos G, Vacanti JP, Langer R. Dynamics of fibrovascular tissue ingrowth in hydrogel foams. Cell Transplant. 1995 May-Jun; 4(3):275-9. PMID: 7543793.
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  875. Shefer SD, Breslau J, Langer R. Computer simulation of low-density lipoprotein removal in the presence of a bioreactor containing phospholipase A2. Biotechnol Prog. 1995 Mar-Apr; 11(2):133-9. PMID: 7766097.
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  876. Takeda T, Kim TH, Lee SK, Langer R, Vacanti JP. Hepatocyte transplantation in biodegradable polymer scaffolds using the Dalmatian dog model of hyperuricosuria. Transplant Proc. 1995 Feb; 27(1):635-6. PMID: 7879127.
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  877. Mooney DJ, Breuer C, McNamara K, Vacanti JP, Langer R. Fabricating tubular devices from polymers of lactic and glycolic Acid for tissue engineering. Tissue Eng. 1995; 1(2):107-18. PMID: 19877920.
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  883. Mooney DJ, Kaufmann PM, Sano K, McNamara KM, Vacanti JP, Langer R. Transplantation of hepatocytes using porous, biodegradable sponges. Transplant Proc. 1994 Dec; 26(6):3425-6. PMID: 7998204.
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  884. Sakata J, Vacanti CA, Schloo B, Healy GB, Langer R, Vacanti JP. Tracheal composites tissue engineered from chondrocytes, tracheal epithelial cells, and synthetic degradable scaffolding. Transplant Proc. 1994 Dec; 26(6):3309-10. PMID: 7998148.
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  885. Prausnitz MR, Pliquett U, Langer R, Weaver JC. Rapid temporal control of transdermal drug delivery by electroporation. Pharm Res. 1994 Dec; 11(12):1834-7. PMID: 7899252.
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  886. Shieh L, Tamada J, Chen I, Pang J, Domb A, Langer R. Erosion of a new family of biodegradable polyanhydrides. J Biomed Mater Res. 1994 Dec; 28(12):1465-75. PMID: 7876286.
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  887. Cao Y, Vacanti JP, Ma X, Paige KT, Upton J, Chowanski Z, Schloo B, Langer R, Vacanti CA. Generation of neo-tendon using synthetic polymers seeded with tenocytes. Transplant Proc. 1994 Dec; 26(6):3390-2. PMID: 7998187.
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  888. Mooney DJ, Hansen LK, Langer R, Vacanti JP, Ingber DE. Extracellular matrix controls tubulin monomer levels in hepatocytes by regulating protein turnover. Mol Biol Cell. 1994 Dec; 5(12):1281-8. PMID: 7696710; PMCID: PMC301157.
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  890. Ferreira JP, Sasisekharan R, Louie O, Langer R. A study on the functional subunits of phospholipases A2 by enzyme immobilization. Biochem J. 1994 Oct 15; 303 ( Pt 2):527-30. PMID: 7980413; PMCID: PMC1137359.
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  892. Puelacher WC, Mooney D, Langer R, Upton J, Vacanti JP, Vacanti CA. Design of nasoseptal cartilage replacements synthesized from biodegradable polymers and chondrocytes. Biomaterials. 1994 Aug; 15(10):774-8. PMID: 7986941.
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  893. Freed LE, Grande DA, Lingbin Z, Emmanual J, Marquis JC, Langer R. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds. J Biomed Mater Res. 1994 Aug; 28(8):891-9. PMID: 7983087.
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  894. Ferreira JP, Sasisekharan R, Louie O, Langer R. Carbodiimide modification enhances activity of pig pancreatic phospholipase A2. Eur J Biochem. 1994 Jul 15; 223(2):611-6. PMID: 8055932.
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  897. Venkataraman G, Sasisekharan V, Cooney CL, Langer R, Sasisekharan R. A stereochemical approach to pyranose ring flexibility: its implications for the conformation of dermatan sulfate. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):6171-5. PMID: 8016133; PMCID: PMC44160.
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  899. Wong JY, Langer R, Ingber DE. Electrically conducting polymers can noninvasively control the shape and growth of mammalian cells. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3201-4. PMID: 8159724; PMCID: PMC43543.
  900. Freed LE, Marquis JC, Langer R, Vunjak-Novakovic G, Emmanual J. Composition of cell-polymer cartilage implants. Biotechnol Bioeng. 1994 Mar 25; 43(7):605-14. PMID: 18615760.
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  901. Freed LE, Marquis JC, Langer R, Vunjak-Novakovic G. Kinetics of chondrocyte growth in cell-polymer implants. Biotechnol Bioeng. 1994 Mar 25; 43(7):597-604. PMID: 18615759.
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  902. Gref R, Minamitake Y, Peracchia MT, Trubetskoy V, Torchilin V, Langer R. Biodegradable long-circulating polymeric nanospheres. Science. 1994 Mar 18; 263(5153):1600-3. PMID: 8128245.
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  904. Wu MP, Tamada JA, Brem H, Langer R. In vivo versus in vitro degradation of controlled release polymers for intracranial surgical therapy. J Biomed Mater Res. 1994 Mar; 28(3):387-95. PMID: 8077254.
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  905. Alonso MJ, Gupta RK, Min C, Siber GR, Langer R. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems. Vaccine. 1994 Mar; 12(4):299-306. PMID: 8178550.
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  906. Sasisekharan R, Moses MA, Nugent MA, Cooney CL, Langer R. Heparinase inhibits neovascularization. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1524-8. PMID: 7509076; PMCID: PMC43192.
  907. Costantino HR, Langer R, Klibanov AM. Moisture-induced aggregation of lyophilized insulin. Pharm Res. 1994 Jan; 11(1):21-9. PMID: 8140052.
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  908. Tabata Y, Domb A, Langer R. Injectable polyanhydride granules provide controlled release of water-soluble drugs with a reduced initial burst. J Pharm Sci. 1994 Jan; 83(1):5-11. PMID: 8138910.
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  909. Mikos AG, Lyman MD, Freed LE, Langer R. Wetting of poly(L-lactic acid) and poly(DL-lactic-co-glycolic acid) foams for tissue culture. Biomaterials. 1994 Jan; 15(1):55-8. PMID: 8161659.
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  911. Prausnitz MR, Bose VG, Langer R, Weaver JC. Electroporation of mammalian skin: a mechanism to enhance transdermal drug delivery. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10504-8. PMID: 8248137; PMCID: PMC47805.
  912. Masters DB, Berde CB, Dutta S, Turek T, Langer R. Sustained local anesthetic release from bioerodible polymer matrices: a potential method for prolonged regional anesthesia. Pharm Res. 1993 Oct; 10(10):1527-32. PMID: 8272418.
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  914. Ferreira JP, Sasisekharan R, Louie O, Langer R. Influence of chemistry in immobilization of cobra venom phospholipase A2: implications as to mechanism. Biochemistry. 1993 Aug 17; 32(32):8098-102. PMID: 8347610.
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  915. Gilbert JC, Takada T, Stein JE, Langer R, Vacanti JP. Cell transplantation of genetically altered cells on biodegradable polymer scaffolds in syngeneic rats. Transplantation. 1993 Aug; 56(2):423-7. PMID: 8356600.
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  923. Sasisekharan R, Bulmer M, Moremen KW, Cooney CL, Langer R. Cloning and expression of heparinase I gene from Flavobacterium heparinum. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3660-4. PMID: 8475114; PMCID: PMC46361.
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  929. Mikos AG, Bao Y, Cima LG, Ingber DE, Vacanti JP, Langer R. Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. J Biomed Mater Res. 1993 Feb; 27(2):183-9. PMID: 8382203.
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  930. Fontaine M, Hansen LK, Thompson S, Uyama S, Ingber DE, Langer R, Vacanti JP. Transplantation of genetically altered hepatocytes using cell-polymer constructs. Transplant Proc. 1993 Feb; 25(1 Pt 2):1002-4. PMID: 8442022.
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  931. Tamada JA, Langer R. Erosion kinetics of hydrolytically degradable polymers. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):552-6. PMID: 8421690; PMCID: PMC45701.
  932. Cohen S, Baño MC, Cima LG, Allcock HR, Vacanti JP, Vacanti CA, Langer R. Design of synthetic polymeric structures for cell transplantation and tissue engineering. Clin Mater. 1993; 13(1-4):3-10. PMID: 10146238.
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  933. Freed LE, Vunjak-Novakovic GV, Drinker PA, Langer R. Bioreactor based on suspended particles of immobilized enzyme. Ann Biomed Eng. 1993; 21(1):57-65. PMID: 8434821.
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  934. Freed LE, Marquis JC, Nohria A, Emmanual J, Mikos AG, Langer R. Neocartilage formation in vitro and in vivo using cells cultured on synthetic biodegradable polymers. J Biomed Mater Res. 1993 Jan; 27(1):11-23. PMID: 8380593.
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  935. Wald HL, Sarakinos G, Lyman MD, Mikos AG, Vacanti JP, Langer R. Cell seeding in porous transplantation devices. Biomaterials. 1993; 14(4):270-8. PMID: 8476996.
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  936. Freed LE, Vunjak-Novakovic GV, Bernstein H, Cooney CL, Langer R. Kinetics of immobilized heparinase in human blood. Ann Biomed Eng. 1993; 21(1):67-76. PMID: 8434822.
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  937. Edelman ER, Fiorino A, Grodzinsky A, Langer R. Mechanical deformation of polymer matrix controlled release devices modulates drug release. J Biomed Mater Res. 1992 Dec; 26(12):1619-31. PMID: 1484066.
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  938. Sluzky V, Klibanov AM, Langer R. Mechanism of insulin aggregation and stabilization in agitated aqueous solutions. Biotechnol Bioeng. 1992 Oct 20; 40(8):895-903. PMID: 18601196.
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  939. D'Emanuele A, Hill J, Tamada JA, Domb AJ, Langer R. Molecular weight changes in polymer erosion. Pharm Res. 1992 Oct; 9(10):1279-83. PMID: 1448426.
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  940. Moses MA, Sudhalter J, Langer R. Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes. J Cell Biol. 1992 Oct; 119(2):475-82. PMID: 1383232; PMCID: PMC2289656.
  941. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 1992 Sep 03; 359(6390):67-70. PMID: 1522889.
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  942. Soltys PJ, Mullon C, Langer R. Oral treatment for jaundice using immobilized bilirubin oxidase. Artif Organs. 1992 Aug; 16(4):331-5. PMID: 10078270.
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  943. Mooney D, Hansen L, Vacanti J, Langer R, Farmer S, Ingber D. Switching from differentiation to growth in hepatocytes: control by extracellular matrix. J Cell Physiol. 1992 Jun; 151(3):497-505. PMID: 1295898.
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  944. Langer R. Angiogenesis--biomedical technology. EXS. 1992; 61:23-5. PMID: 1377534.
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  945. Langer R. Delivery systems for angiogenesis stimulators and inhibitors. EXS. 1992; 61:327-30. PMID: 1377552.
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  946. Tamada J, Langer R. The development of polyanhydrides for drug delivery applications. J Biomater Sci Polym Ed. 1992; 3(4):315-53. PMID: 1350734.
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  947. Park TG, Cohen S, Langer R. Controlled protein release from polyethyleneimine-coated poly(L-lactic acid)/pluronic blend matrices. Pharm Res. 1992 Jan; 9(1):37-9. PMID: 1589407.
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  948. Wintermantel E, Cima L, Schloo B, Langer R. Angiopolarity of cell carriers: directional angiogenesis in resorbable liver cell transplantation devices. EXS. 1992; 61:331-4. PMID: 1377553.
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  949. Cohen S, Bernstein H, Hewes C, Chow M, Langer R. The pharmacokinetics of, and humoral responses to, antigen delivered by microencapsulated liposomes. Proc Natl Acad Sci U S A. 1991 Dec 01; 88(23):10440-4. PMID: 1961708; PMCID: PMC52944.
  950. Sluzky V, Tamada JA, Klibanov AM, Langer R. Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9377-81. PMID: 1946348; PMCID: PMC52720.
  951. Vacanti CA, Langer R, Schloo B, Vacanti JP. Synthetic polymers seeded with chondrocytes provide a template for new cartilage formation. Plast Reconstr Surg. 1991 Nov; 88(5):753-9. PMID: 1924560.
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  952. Moses MA, Langer R. A metalloproteinase inhibitor as an inhibitor of neovascularization. J Cell Biochem. 1991 Nov; 47(3):230-5. PMID: 1724245.
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  953. Edelman ER, Mathiowitz E, Langer R, Klagsbrun M. Controlled and modulated release of basic fibroblast growth factor. Biomaterials. 1991 Sep; 12(7):619-26. PMID: 1742404.
    View in: PubMed
  954. Cima LG, Ingber DE, Vacanti JP, Langer R. Hepatocyte culture on biodegradable polymeric substrates. Biotechnol Bioeng. 1991 Jun 20; 38(2):145-58. PMID: 18600745.
    View in: PubMed
  955. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res. 1991 Jun; 8(6):713-20. PMID: 2062800.
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  956. Cima LG, Vacanti JP, Vacanti C, Ingber D, Mooney D, Langer R. Tissue engineering by cell transplantation using degradable polymer substrates. J Biomech Eng. 1991 May; 113(2):143-51. PMID: 1652042.
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  957. Carmen Bañó M, Cohen S, Visscher KB, Allcock HR, Langer R. A novel synthetic method for hybridoma cell encapsulation. Biotechnology (N Y). 1991 May; 9(5):468-71. PMID: 1367311.
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  958. Volkin DB, Staubli A, Langer R, Klibanov AM. Enzyme thermoinactivation in anhydrous organic solvents. Biotechnol Bioeng. 1991 Apr 15; 37(9):843-53. PMID: 18600684.
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  959. Langer R, Moses M. Biocompatible controlled release polymers for delivery of polypeptides and growth factors. J Cell Biochem. 1991 Apr; 45(4):340-5. PMID: 2045427.
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  960. Cohen S, Bañó MC, Chow M, Langer R. Lipid-alginate interactions render changes in phospholipid bilayer permeability. Biochim Biophys Acta. 1991 Mar 18; 1063(1):95-102. PMID: 2015266.
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  961. Leckband D, Langer R. An approach for the stable immobilization of proteins. Biotechnol Bioeng. 1991 Feb 05; 37(3):227-37. PMID: 18597360.
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  962. Liu WR, Langer R, Klibanov AM. Moisture-induced aggregation of lyophilized proteins in the solid state. Biotechnol Bioeng. 1991 Jan 20; 37(2):177-84. PMID: 18597353.
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  963. Madrid Y, Langer LF, Brem H, Langer R. New directions in the delivery of drugs and other substances to the central nervous system. Adv Pharmacol. 1991; 22:299-324. PMID: 1958504.
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  964. Langer R, Kost J. Real time response polymeric delivery systems. Ann N Y Acad Sci. 1991; 618:330-4. PMID: 2006793.
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  965. Langer R, Cima LG, Tamada JA, Wintermantel E. Future directions in biomaterials. Biomaterials. 1990 Nov; 11(9):738-45. PMID: 2090313.
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  966. Laurencin C, Domb A, Morris C, Brown V, Chasin M, McConnell R, Lange N, Langer R. Poly(anhydride) administration in high doses in vivo: studies of biocompatibility and toxicology. J Biomed Mater Res. 1990 Nov; 24(11):1463-81. PMID: 2279981.
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  967. Langer R. New methods of drug delivery. Science. 1990 Sep 28; 249(4976):1527-33. PMID: 2218494.
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  968. Laurencin CT, Pierre-Jacques HM, Langer R. Toxicology and biocompatibility considerations in the evaluation of polymeric materials for biomedical applications. Clin Lab Med. 1990 Sep; 10(3):549-70. PMID: 2253450.
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  969. Lucas PA, Laurencin C, Syftestad GT, Domb A, Goldberg VM, Caplan AI, Langer R. Ectopic induction of cartilage and bone by water-soluble proteins from bovine bone using a polyanhydride delivery vehicle. J Biomed Mater Res. 1990 Jul; 24(7):901-11. PMID: 2398077.
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  970. Mathiowitz E, Kline D, Langer R. Morphology of polyanhydride microsphere delivery systems. Scanning Microsc. 1990 Jun; 4(2):329-40. PMID: 2205908.
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  971. Kibat PG, Igari Y, Wheatley MA, Eisen HN, Langer R. Enzymatically activated microencapsulated liposomes can provide pulsatile drug release. FASEB J. 1990 May; 4(8):2533-9. PMID: 2110539.
    View in: PubMed
  972. Aiken J, Cima L, Schloo B, Mooney D, Johnson L, Langer R, Vacanti JP. Studies in rat liver perfusion for optimal harvest of hepatocytes. J Pediatr Surg. 1990 Jan; 25(1):140-4; discussion 144-5. PMID: 2153793.
    View in: PubMed
  973. Comfort AR, Berkowitz S, Albert E, Langer R. Immobilized enzyme cellulose hollow fibers: III. Physical properties and in vitro biocompatibility. Biotechnol Bioeng. 1989 Dec 20; 34(11):1383-90. PMID: 18588081.
    View in: PubMed
  974. Comfort AR, Albert E, Langer R. Immobilized enzyme cellulose hollow fibers: II. Kinetic analysis. Biotechnol Bioeng. 1989 Dec 20; 34(11):1374-82. PMID: 18588080.
    View in: PubMed
  975. Comfort AR, Albert EC, Langer R. Immobilized enzyme cellulose hollow fibers: I. Immobilization of heparinase. Biotechnol Bioeng. 1989 Dec 20; 34(11):1366-73. PMID: 18588079.
    View in: PubMed
  976. Langer R, Brem H, Langer LF. New directions in CNS drug delivery. Neurobiol Aging. 1989 Sep-Oct; 10(5):642-4; discussion 648-50. PMID: 2812246.
    View in: PubMed
  977. Levy D, Kost J, Meshulam Y, Langer R. Effect of ultrasound on transdermal drug delivery to rats and guinea pigs. J Clin Invest. 1989 Jun; 83(6):2074-8. PMID: 2498396; PMCID: PMC303933.
  978. Freese A, Sabel BA, Saltzman WM, During MJ, Langer R. Controlled release of dopamine from a polymeric brain implant: in vitro characterization. Exp Neurol. 1989 Mar; 103(3):234-8. PMID: 2920789.
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  979. Larsen AK, Rice KG, Linhardt RJ, Wogan G, Langer R. Resistance of heparinase-derived heparin fragments to biotransformation. J Biol Chem. 1989 Jan 25; 264(3):1570-7. PMID: 2912974.
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  980. Saltzman WM, Langer R. Transport rates of proteins in porous materials with known microgeometry. Biophys J. 1989 Jan; 55(1):163-71. PMID: 2467696; PMCID: PMC1330451.
  981. Brem H, Kader A, Epstein JI, Tamargo RJ, Domb A, Langer R, Leong KW. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Sel Cancer Ther. 1989; 5(2):55-65. PMID: 2772427.
    View in: PubMed
  982. Bernstein H, Langer R. Ex vivo model of an immobilized-enzyme reactor. Proc Natl Acad Sci U S A. 1988 Nov; 85(22):8751-5. PMID: 3186758; PMCID: PMC282539.
  983. Langer R. Biodegradable polymers for drug delivery to the brain. ASAIO Trans. 1988 Oct-Dec; 34(4):945-6. PMID: 2851308.
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  984. Comfort AR, Mullon CJ, Langer R. The influence of bond chemistry on immobilized enzyme systems for ex vivo use. Biotechnol Bioeng. 1988 Aug 05; 32(4):554-63. PMID: 18587754.
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  985. Comfort AR, Mullon CJ, Koh J, Albert E, Tosone CP, Hall J, Langer R. Stability and immunologic activity of immobilized heparinase and bilirubin oxidase. ASAIO Trans. 1988 Jul-Sep; 34(3):538-42. PMID: 3196560.
    View in: PubMed
  986. Freed LE, Vunjak GV, Drinker PA, Langer R. A novel bioreactor based on suspended particles of agarose-immobilized species. ASAIO Trans. 1988 Jul-Sep; 34(3):732-8. PMID: 3196592.
    View in: PubMed
  987. Chang TM, Langer R, Sparks RE, Reach G. Drug delivery systems in biotechnology. Artif Organs. 1988 Jun; 12(3):248-51. PMID: 3291832.
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  988. Million CJ, Klibanov AM, Langer R. Kinetics of bilirubin oxidase and modeling of an immobilized bilirubin oxidase reactor for bilirubin detoxification. Biotechnol Bioeng. 1988 Apr 20; 31(6):536-46. PMID: 18584643.
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  989. Vacanti JP, Morse MA, Saltzman WM, Domb AJ, Perez-Atayde A, Langer R. Selective cell transplantation using bioabsorbable artificial polymers as matrices. J Pediatr Surg. 1988 Jan; 23(1 Pt 2):3-9. PMID: 2895175.
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  990. Kost J, Wolfrum J, Langer R. Magnetically enhanced insulin release in diabetic rats. J Biomed Mater Res. 1987 Dec; 21(12):1367-73. PMID: 3323204.
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  991. Laurencin CT, Koh HJ, Neenan TX, Allcock HR, Langer R. Controlled release using a new bioerodible polyphosphazene matrix system. J Biomed Mater Res. 1987 Oct; 21(10):1231-46. PMID: 3693386.
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  992. Bernstein H, Yang VC, Lund D, Randhawa M, Harmon W, Langer R. Extracorporeal enzymatic heparin removal: use in a sheep dialysis model. Kidney Int. 1987 Oct; 32(4):452-63. PMID: 3430948.
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  993. Bernstein H, Yang VC, Langer R. An investigation of heparinase immobilization. Appl Biochem Biotechnol. 1987 Sep-Dec; 16:129-43. PMID: 3504126.
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  994. Bernstein H, Yang VC, Langer R. Immobilized heparinase: In vitro reactor model. Biotechnol Bioeng. 1987 Aug 05; 30(2):239-50. PMID: 18581305.
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  995. Bernstein H, Yang VC, Langer R. Distribution of heparinase covalently immobilized to agarose: Experimental and theoretical studies. Biotechnol Bioeng. 1987 Aug 05; 30(2):196-207. PMID: 18581300.
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  996. Cuénoud HF, Joris I, Langer RS, Majno G. Focal arteriolar insudation. A response of arterioles to chronic nonspecific irritation. Am J Pathol. 1987 Jun; 127(3):592-604. PMID: 3296773; PMCID: PMC1899760.
  997. Linhardt RJ, Langer R. New approaches for anticoagulation in extracorporeal therapy. Biomater Artif Cells Artif Organs. 1987; 15(1):91-100. PMID: 2835116.
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  998. Kohn J, Niemi SM, Albert EC, Murphy JC, Langer R, Fox JG. Single-step immunization using a controlled release, biodegradable polymer with sustained adjuvant activity. J Immunol Methods. 1986 Dec 04; 95(1):31-8. PMID: 3782824.
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  999. Sung C, Lavin A, Klibanov AM, Langer R. An immobilized enzyme reactor for the detoxification of bilirubin. Biotechnol Bioeng. 1986 Oct; 28(10):1531-9. PMID: 18553870.
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  1000. Blackshear PJ, Robbins DC, Rohde TD, Langer RS, Moses AC, Massey EH. Insulin replacement: current concepts. ASAIO Trans. 1986 Oct-Dec; 32(2):646-55. PMID: 3541984.
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  1001. Leong KW, Kost J, Mathiowitz E, Langer R. Polyanhydrides for controlled release of bioactive agents. Biomaterials. 1986 Sep; 7(5):364-71. PMID: 3778996.
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  1002. Kohn J, Langer R. Poly(iminocarbonates) as potential biomaterials. Biomaterials. 1986 May; 7(3):176-82. PMID: 3719035.
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  1003. Leong KW, D'Amore PD, Marletta M, Langer R. Bioerodible polyanhydrides as drug-carrier matrices. II. Biocompatibility and chemical reactivity. J Biomed Mater Res. 1986 Jan; 20(1):51-64. PMID: 3949823.
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  1004. Niemi SM, Fox JG, Brown LR, Langer R. Evaluation of ethylene-vinyl acetate copolymer as a non-inflammatory alternative to Freund's complete adjuvant in rabbits. Lab Anim Sci. 1985 Dec; 35(6):609-12. PMID: 4094398.
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  1005. Leong KW, Brott BC, Langer R. Bioerodible polyanhydrides as drug-carrier matrices. I: Characterization, degradation, and release characteristics. J Biomed Mater Res. 1985 Oct; 19(8):941-55. PMID: 3880353.
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  1006. Langer R, Siegel R, Brown L, Leong K, Kost J, Edelman E. Controlled release and magnetically modulated systems for macromolecular drugs. Ann N Y Acad Sci. 1985; 446:1-13. PMID: 3893280.
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  1007. Edelman ER, Brown L, Kost J, Taylor J, Langer R. Modulated release from polymeric drug delivery systems using oscillating magnetic fields: in vitro and in vivo characteristics. Trans Am Soc Artif Intern Organs. 1984; 30:445-9. PMID: 6533921.
    View in: PubMed
  1008. Brown LR, Wei CL, Langer R. In vivo and in vitro release of macromolecules from polymeric drug delivery systems. J Pharm Sci. 1983 Oct; 72(10):1181-5. PMID: 6644569.
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  1009. Lee A, Langer R. Shark cartilage contains inhibitors of tumor angiogenesis. Science. 1983 Sep 16; 221(4616):1185-7. PMID: 6193581.
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  1010. Kupchik HZ, Langer RS, Haberern C, El Deriny S, O'Brien M. A new method for the three-dimensional in vitro growth of human cancer cells. Exp Cell Res. 1983 Sep; 147(2):454-60. PMID: 6352294.
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  1011. Rosen HB, Chang J, Wnek GE, Linhardt RJ, Langer R. Bioerodible polyanhydrides for controlled drug delivery. Biomaterials. 1983 Apr; 4(2):131-3. PMID: 6860755.
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  1012. Langer RS, Peppas NA. Present and future applications of biomaterials in controlled drug delivery systems. Biomaterials. 1981 Oct; 2(4):201-14. PMID: 7034798.
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  1013. Langer R, Brem H, Tapper D. Biocompatibility of polymeric delivery systems for macromolecules. J Biomed Mater Res. 1981 Mar; 15(2):267-77. PMID: 7348718.
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  1014. Langer R, Conn H, Vacanti J, Haudenschild C, Folkman J. Control of tumor growth in animals by infusion of an angiogenesis inhibitor. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4331-5. PMID: 6159628; PMCID: PMC349828.
  1015. Tapper D, Langer RS, Conn H, Folkman J. Oxygen content determined by acrylamide polymerization: screening of anticancer agents, generation of oxyhemoglobin dissociation curves, and potential applications. Ann Surg. 1979 Mar; 189(3):275-82. PMID: 85435; PMCID: PMC1397110.
  1016. Preis I, Langer RS. A single-step immunization by sustained antigen release. J Immunol Methods. 1979; 28(1-2):193-7. PMID: 469267.
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  1017. Preis I, Langer R, Brem H, Folkman J. Inhibition of neovascularization by an extract derived from vitreous. Am J Ophthalmol. 1977 Sep; 84(3):323-8. PMID: 900228.
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  1018. Klagsbrun M, Langer R, Levenson R, Smith S, Lillehei C. The stimulation of DNA synthesis and cell division in chondrocytes and 3T3 cells by a growth factor isolated from cartilage. Exp Cell Res. 1977 Mar 01; 105(1):99-108. PMID: 556995.
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  1019. Langer R, Folkman J. Polymers for the sustained release of proteins and other macromolecules. Nature. 1976 Oct 28; 263(5580):797-800. PMID: 995197.
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  1020. Langer R, Brem H, Falterman K, Klein M, Folkman J. Isolations of a cartilage factor that inhibits tumor neovascularization. Science. 1976 Jul 02; 193(4247):70-2. PMID: 935859.
    View in: PubMed
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