Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Sekar Kathiresan, M.D.

Co-Author

This page shows the publications co-authored by Sekar Kathiresan and Pradeep Natarajan.
Connection Strength

9.336
  1. Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis. Circ Genom Precis Med. 2018 07; 11(7):e001926.
    View in: PubMed
    Score: 0.817
  2. Polygenic Risk Score Identifies Subgroup With Higher Burden of Atherosclerosis and Greater Relative Benefit From Statin Therapy in the Primary Prevention Setting. Circulation. 2017 May 30; 135(22):2091-2101.
    View in: PubMed
    Score: 0.744
  3. PCSK9 Inhibitors. Cell. 2016 May 19; 165(5):1037.
    View in: PubMed
    Score: 0.706
  4. Association of APOC3 Loss-of-Function Mutations With Plasma Lipids and Subclinical Atherosclerosis: The Multi-Ethnic BioImage Study. J Am Coll Cardiol. 2015 Nov 03; 66(18):2053-2055.
    View in: PubMed
    Score: 0.680
  5. Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices. Nat Commun. 2021 04 12; 12(1):2182.
    View in: PubMed
    Score: 0.248
  6. Author Correction: Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2021 Mar; 591(7851):E27.
    View in: PubMed
    Score: 0.246
  7. Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature. 2020 10; 586(7831):763-768.
    View in: PubMed
    Score: 0.239
  8. Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease. Circ Genom Precis Med. 2020 10; 13(5):417-423.
    View in: PubMed
    Score: 0.237
  9. Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. J Am Coll Cardiol. 2020 06 09; 75(22):2769-2780.
    View in: PubMed
    Score: 0.234
  10. Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis. Circulation. 2020 01 14; 141(2):124-131.
    View in: PubMed
    Score: 0.224
  11. Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week. J Am Coll Cardiol. 2019 07 30; 74(4):578-586.
    View in: PubMed
    Score: 0.220
  12. Whole-Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized With Early-Onset Myocardial Infarction. Circulation. 2019 03 26; 139(13):1593-1602.
    View in: PubMed
    Score: 0.215
  13. DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes. Diabetes. 2019 01; 68(1):226-234.
    View in: PubMed
    Score: 0.209
  14. Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nat Commun. 2018 08 23; 9(1):3391.
    View in: PubMed
    Score: 0.206
  15. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations. Nat Genet. 2018 09; 50(9):1219-1224.
    View in: PubMed
    Score: 0.206
  16. Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease. Nat Commun. 2018 04 24; 9(1):1613.
    View in: PubMed
    Score: 0.202
  17. Phenotypic Consequences of a Genetic Predisposition to Enhanced Nitric Oxide Signaling. Circulation. 2018 01 16; 137(3):222-232.
    View in: PubMed
    Score: 0.194
  18. Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 2017 Sep; 49(9):1392-1397.
    View in: PubMed
    Score: 0.191
  19. Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease. Circ Res. 2017 Jun 23; 121(1):81-88.
    View in: PubMed
    Score: 0.189
  20. Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity. Nature. 2017 04 12; 544(7649):235-239.
    View in: PubMed
    Score: 0.188
  21. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. Circ Cardiovasc Genet. 2017 Apr; 10(2).
    View in: PubMed
    Score: 0.187
  22. Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease. JAMA. 2017 02 14; 317(6):626-634.
    View in: PubMed
    Score: 0.186
  23. Evaluation of the Pooled Cohort Equations for Prediction of Cardiovascular Risk in a Contemporary Prospective Cohort. Am J Cardiol. 2017 Mar 15; 119(6):881-885.
    View in: PubMed
    Score: 0.184
  24. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec; 9(6):511-520.
    View in: PubMed
    Score: 0.183
  25. Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. N Engl J Med. 2016 12 15; 375(24):2349-2358.
    View in: PubMed
    Score: 0.182
  26. Aggregate penetrance of genomic variants for actionable disorders in European and African Americans. Sci Transl Med. 2016 11 09; 8(364):364ra151.
    View in: PubMed
    Score: 0.182
  27. Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia. J Am Coll Cardiol. 2016 06 07; 67(22):2578-89.
    View in: PubMed
    Score: 0.175
  28. The future of low-density lipoprotein cholesterol lowering therapy: An end to statin exceptionalism? Eur J Prev Cardiol. 2016 07; 23(10):1062-4.
    View in: PubMed
    Score: 0.167
  29. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27; 371(22):2072-82.
    View in: PubMed
    Score: 0.159
  30. Randomized prospective evaluation of genome sequencing versus standard-of-care as a first molecular diagnostic test. Genet Med. 2021 May 11.
    View in: PubMed
    Score: 0.062
  31. Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease. Nat Commun. 2020 12 18; 11(1):6417.
    View in: PubMed
    Score: 0.061
  32. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 10; 586(7831):769-775.
    View in: PubMed
    Score: 0.060
  33. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. 2020 Oct 27; 142(17):1633-1646.
    View in: PubMed
    Score: 0.060
  34. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 09; 52(9):969-983.
    View in: PubMed
    Score: 0.059
  35. Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2020 Apr 01; 11(1):1715.
    View in: PubMed
    Score: 0.058
  36. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet. 2019 11; 51(11):1574-1579.
    View in: PubMed
    Score: 0.056
  37. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation. 2019 09 17; 140(12):1031-1040.
    View in: PubMed
    Score: 0.055
  38. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 08; 25(8):1274-1279.
    View in: PubMed
    Score: 0.055
  39. Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genet Med. 2019 05; 21(5):1173-1180.
    View in: PubMed
    Score: 0.052
  40. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018 11; 50(11):1514-1523.
    View in: PubMed
    Score: 0.052
  41. Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 08 23; 9(1):3493.
    View in: PubMed
    Score: 0.052
  42. Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nat Commun. 2018 07 04; 9(1):2606.
    View in: PubMed
    Score: 0.051
  43. Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. Nat Commun. 2018 06 13; 9(1):2252.
    View in: PubMed
    Score: 0.051
  44. A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels. Nat Med. 2017 Sep; 23(9):1086-1094.
    View in: PubMed
    Score: 0.048
  45. Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. N Engl J Med. 2017 07 13; 377(2):111-121.
    View in: PubMed
    Score: 0.048
  46. An electronic cardiac rehabilitation referral system increases cardiac rehabilitation referrals. Coron Artery Dis. 2017 Jun; 28(4):342-345.
    View in: PubMed
    Score: 0.047
  47. Genetic Variation at the Sulfonylurea Receptor, Type 2 Diabetes, and Coronary Heart Disease. Diabetes. 2017 08; 66(8):2310-2315.
    View in: PubMed
    Score: 0.047
  48. ANGPTL3 Deficiency and Protection Against Coronary Artery Disease. J Am Coll Cardiol. 2017 Apr 25; 69(16):2054-2063.
    View in: PubMed
    Score: 0.047
  49. Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease. JAMA. 2017 03 07; 317(9):937-946.
    View in: PubMed
    Score: 0.047
  50. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):E327-E336.
    View in: PubMed
    Score: 0.046
  51. Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. J Am Coll Cardiol. 2016 Dec 27; 68(25):2761-2772.
    View in: PubMed
    Score: 0.046
  52. Gene-gene Interaction Analyses for Atrial Fibrillation. Sci Rep. 2016 11 08; 6:35371.
    View in: PubMed
    Score: 0.046
  53. Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nat Neurosci. 2016 12; 19(12):1563-1565.
    View in: PubMed
    Score: 0.045
  54. Analysis of protein-coding genetic variation in 60,706 humans. Nature. 2016 08 18; 536(7616):285-91.
    View in: PubMed
    Score: 0.045
  55. A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans. BMC Endocr Disord. 2016 Jan 28; 16:7.
    View in: PubMed
    Score: 0.043
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.