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Jongsoon Lee, PH.D.


This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J. Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metab. 2016 Apr 12; 23(4):685-98. PMID: 27050305.
    Citations: 23     Fields:    Translation:AnimalsCells
  2. Lee J, Miyazaki M, Romeo GR, Shoelson SE. Insulin receptor activation with transmembrane domain ligands. J Biol Chem. 2014 Jul 11; 289(28):19769-77. PMID: 24867955.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  3. Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J. Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone. PLoS One. 2013; 8(12):e82847. PMID: 24376593.
    Citations: 8     Fields:    Translation:AnimalsCells
  4. Romeo GR, Pae M, Eberlé D, Lee J, Shoelson SE. Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes. 2013 Nov; 62(11):3718-26. PMID: 23884883.
    Citations: 4     Fields:    Translation:AnimalsCells
  5. Lee BC, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta. 2014 Mar; 1842(3):446-62. PMID: 23707515.
    Citations: 100     Fields:    Translation:HumansCells
  6. Lee J. Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 diabetes. Arch Pharm Res. 2013 Feb; 36(2):208-22. PMID: 23397293.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32. PMID: 23197686.
    Citations: 7     Fields:    Translation:Animals
  8. Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1771-6. PMID: 22815343.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  9. Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):240-5. PMID: 20007767.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  10. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug; 15(8):930-9. PMID: 19633656.
    Citations: 552     Fields:    Translation:AnimalsCells
  11. Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May; 1(1):36-43. PMID: 19337387.
    Citations: 101     Fields:    Translation:HumansCTClinical Trials
  12. Lee J, Kim MS. The role of GSK3 in glucose homeostasis and the development of insulin resistance. Diabetes Res Clin Pract. 2007 Sep; 77 Suppl 1:S49-57. PMID: 17478001.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  13. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006 Jul; 116(7):1793-801. PMID: 16823477.
    Citations: 1030     Fields:    Translation:HumansCells
  14. Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE. Kinase activation through dimerization by human SH2-B. Mol Cell Biol. 2005 Apr; 25(7):2607-21. PMID: 15767667.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  15. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005 Feb; 11(2):183-90. PMID: 15685173.
    Citations: 598     Fields:    Translation:HumansAnimalsCells
  16. Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GC. Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol. 2004 Nov; 13(3):191-200. PMID: 15381202.
    Citations: 9     Fields:    Translation:AnimalsCells
  17. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004 Oct 15; 119(2):285-98. PMID: 15479644.
    Citations: 371     Fields:    Translation:HumansAnimalsCells
  18. Werner ED, Lee J, Hansen L, Yuan M, Shoelson SE. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J Biol Chem. 2004 Aug 20; 279(34):35298-305. PMID: 15199052.
    Citations: 72     Fields:    Translation:AnimalsCells
  19. Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord. 2003 Dec; 27 Suppl 3:S49-52. PMID: 14704745.
    Citations: 110     Fields:    Translation:HumansAnimals
  20. Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem. 2003 Jul 11; 278(28):25323-30. PMID: 12730241.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  21. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001 Aug 31; 293(5535):1673-7. PMID: 11533494.
    Citations: 506     Fields:    Translation:AnimalsCells
  22. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest. 2001 Aug; 108(3):437-46. PMID: 11489937.
    Citations: 179     Fields:    Translation:AnimalsCells
  23. Woldin CN, Hing FS, Lee J, Pilch PF, Shipley GG. Structural studies of the detergent-solubilized and vesicle-reconstituted insulin receptor. J Biol Chem. 1999 Dec 03; 274(49):34981-92. PMID: 10574975.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. Lee J, Pilch PF, Shoelson SE, Scarlata SF. Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry. 1997 Mar 04; 36(9):2701-8. PMID: 9054578.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Stephens JM, Lee J, Pilch PF. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction. J Biol Chem. 1997 Jan 10; 272(2):971-6. PMID: 8995390.
    Citations: 110     Fields:    Translation:AnimalsCells
  26. Lee J, Shoelson SE, Pilch PF. Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity. J Biol Chem. 1995 Dec 29; 270(52):31136-40. PMID: 8537376.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  27. Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem. 1995 Nov 17; 270(46):27407-10. PMID: 7499194.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  28. Kublaoui B, Lee J, Pilch PF. Dynamics of signaling during insulin-stimulated endocytosis of its receptor in adipocytes. J Biol Chem. 1995 Jan 06; 270(1):59-65. PMID: 7814420.
    Citations: 21     Fields:    Translation:AnimalsCells
  29. Lee J, Pilch PF. The insulin receptor: structure, function, and signaling. Am J Physiol. 1994 Feb; 266(2 Pt 1):C319-34. PMID: 8141246.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  30. Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. J Biol Chem. 1993 Feb 25; 268(6):4085-91. PMID: 8382690.
    Citations: 8     Fields:    Translation:Cells
  31. Lee J, O'Hare T, Pilch PF, Shoelson SE. Insulin receptor autophosphorylation occurs asymmetrically. J Biol Chem. 1993 Feb 25; 268(6):4092-8. PMID: 8440700.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.