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Hiroshi Mashimo, M.D.,Ph.D.

Title
Institution
Department
Address
Phone
Fax

Biography
Harvard College, Cambridge, MAA.B.Biochemical Sciences
Albert Einstein College of Medicine, Bronx, NYM.S.Biomedical Sciences
Albert Einstein College of Medicine, Bronx, NYPh.D.Microbiology and Immunology
Albert Einstein College of Medicine, Bronx, NYM.D.Medicine
Massachusetts General Hospital, Boston, MAInternal Medicine Internship/Residency
Massachusetts General Hospital, Boston, MAGastroenterology Fellowship
Massachusetts General Hospital, Charlestown, MAResearch Fellowship

Mentoring
Available: 07/01/17, Expires: 09/01/20

Students will participate in ongoing projects of the research group including engineering of stem cells and assessment of changes in cellular expression using cell culture models. Techniques include immunohistochemistry, molecular biology, and proteomics.


Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD. Randomized Trial of Medical versus Surgical Treatment for Refractory Heartburn. N Engl J Med. 2019 10 17; 381(16):1513-1523. PMID: 31618539.
    Citations:    
  2. Ahsen OO, Liang K, Lee HC, Wang Z, Fujimoto JG, Mashimo H. Assessment of chronic radiation proctopathy and radiofrequency ablation treatment follow-up with optical coherence tomography angiography: A pilot study. World J Gastroenterol. 2019 Apr 28; 25(16):1997-2009. PMID: 31086467.
    Citations:    
  3. Goyal RK, Guo Y, Mashimo H. Advances in the physiology of gastric emptying. Neurogastroenterol Motil. 2019 04; 31(4):e13546. PMID: 30740834.
    Citations:    
  4. Mkarimi M, Mashimo H. Advanced Imaging for Barrett's Esophagus and Early Neoplasia: Surface and Subsurface Imaging for Diagnosis and Management. Curr Gastroenterol Rep. 2018 Oct 09; 20(12):54. PMID: 30302571.
    Citations:    Fields:    
  5. Ahsen OO, Liang K, Lee HC, Giacomelli MG, Wang Z, Potsaid B, Figueiredo M, Huang Q, Jayaraman V, Fujimoto JG, Mashimo H. Assessment of Barrett's esophagus and dysplasia with ultrahigh-speed volumetric en face and cross-sectional optical coherence tomography. Endoscopy. 2019 04; 51(4):355-359. PMID: 30261534.
    Citations:    Fields:    
  6. Inadomi J, Alastal H, Bonavina L, Gross S, Hunt RH, Mashimo H, di Pietro M, Rhee H, Shah M, Tolone S, Wang DH, Xie SH. Recent advances in Barrett's esophagus. Ann N Y Acad Sci. 2018 12; 1434(1):227-238. PMID: 29974975.
    Citations:    Fields:    
  7. Huang Q, Cheng Y, Chen L, Mingzhan D, Wang Y, Xu G, Shi J, Fan X, Zhou X, Zhang Y, Guo L, Liu T, Zhou D, Mashimo H, Gold JS, Zou X. Low risk of lymph node metastasis in 495 early gastric cardiac carcinomas: a multicenter clinicopathologic study of 2101 radical gastrectomies for early gastric carcinoma. Mod Pathol. 2018 10; 31(10):1599-1607. PMID: 29802360.
    Citations:    Fields:    
  8. Liang K, Wang Z, Ahsen OO, Lee HC, Potsaid BM, Jayaraman V, Cable A, Mashimo H, Li X, Fujimoto JG. Cycloid scanning for wide field optical coherence tomography endomicroscopy and angiography in vivo. Optica. 2018 Jan 20; 5(1):36-43. PMID: 29682598.
    Citations: 1     
  9. Tsai TH, Leggett CL, Trindade AJ, Sethi A, Swager AF, Joshi V, Bergman JJ, Mashimo H, Nishioka NS, Namati E. Optical coherence tomography in gastroenterology: a review and future outlook. J Biomed Opt. 2017 Dec; 22(12):1-17. PMID: 29260538.
    Citations:    Fields:    Translation:Humans
  10. Ahsen OO, Lee HC, Liang K, Wang Z, Figueiredo M, Huang Q, Potsaid B, Jayaraman V, Fujimoto JG, Mashimo H. Ultrahigh-speed endoscopic optical coherence tomography and angiography enables delineation of lateral margins of endoscopic mucosal resection: a case report. Therap Adv Gastroenterol. 2017 Dec; 10(12):931-936. PMID: 29204188.
    Citations: 1     
  11. Liang K, Ahsen OO, Wang Z, Lee HC, Liang W, Potsaid BM, Tsai TH, Giacomelli MG, Jayaraman V, Mashimo H, Li X, Fujimoto JG. Endoscopic forward-viewing optical coherence tomography and angiography with MHz swept source. Opt Lett. 2017 Aug 15; 42(16):3193-3196. PMID: 28809905.
    Citations: 2     Fields:    
  12. Lee HC, Ahsen OO, Liu JJ, Tsai TH, Huang Q, Mashimo H, Fujimoto JG. Assessment of the radiofrequency ablation dynamics of esophageal tissue with optical coherence tomography. J Biomed Opt. 2017 07 01; 22(7):76001. PMID: 28687822.
    Citations: 2     Fields:    Translation:Humans
  13. Lee HC, Ahsen OO, Liang K, Wang Z, Figueiredo M, Giacomelli MG, Potsaid B, Huang Q, Mashimo H, Fujimoto JG. Endoscopic optical coherence tomography angiography microvascular features associated with dysplasia in Barrett's esophagus (with video). Gastrointest Endosc. 2017 Sep; 86(3):476-484.e3. PMID: 28167119.
    Citations: 4     Fields:    Translation:Humans
  14. Shapiro M, Nandi B, Gonzalez G, Prabhala RH, Mashimo H, Huang Q, Frank NY, Munshi NC, Gold JS. Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis. Oncoimmunology. 2017; 6(1):e1261776. PMID: 28197386.
    Citations:    
  15. Tang Q, Wang J, Frank A, Lin J, Li Z, Chen CW, Jin L, Wu T, Greenwald BD, Mashimo H, Chen Y. Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography. Biomed Opt Express. 2016 Dec 01; 7(12):5218-5232. PMID: 28018738.
    Citations: 5     
  16. Liang K, Ahsen OO, Lee HC, Wang Z, Potsaid BM, Figueiredo M, Jayaraman V, Cable AE, Huang Q, Mashimo H, Fujimoto JG. Volumetric Mapping of Barrett's Esophagus and Dysplasia With en face Optical Coherence Tomography Tethered Capsule. Am J Gastroenterol. 2016 11; 111(11):1664-1666. PMID: 27808130.
    Citations: 7     Fields:    Translation:Humans
  17. Lee HC, Ahsen OO, Liang K, Wang Z, Cleveland C, Booth L, Potsaid B, Jayaraman V, Cable AE, Mashimo H, Langer R, Traverso G, Fujimoto JG. Circumferential optical coherence tomography angiography imaging of the swine esophagus using a micromotor balloon catheter. Biomed Opt Express. 2016 Aug 01; 7(8):2927-42. PMID: 27570688.
    Citations: 8     
  18. Zhao X, Mashimo H. Current and Emerging Medical Therapies for Gastroparesis. Curr Treat Options Gastroenterol. 2015 Dec; 13(4):452-72. PMID: 26507073.
    Citations: 1     
  19. Huang Q, Shi J, Sun Q, Gold JS, Chen J, Wu H, Yu H, Zhang Y, Mashimo H, Yu C, Manasco T, Guan W, Lauwers GY. Clinicopathological characterisation of small (2?cm or less) proximal and distal gastric carcinomas in a Chinese population. Pathology. 2015 Oct; 47(6):526-32. PMID: 26166663.
    Citations: 3     Fields:    Translation:Humans
  20. Lo WK, Mashimo H. Critical Assessment of Endoscopic Techniques for Gastroesophageal Reflux Disease. J Clin Gastroenterol. 2015 Oct; 49(9):720-4. PMID: 26241152.
    Citations: 1     Fields:    Translation:Humans
  21. Huang Q, Fang C, Shi J, Sun Q, Wu H, Gold JS, Weber HC, Guan W, Zhang Y, Yu C, Zou X, Mashimo H. Differences in Clinicopathology of Early Gastric Carcinoma between Proximal and Distal Location in 438 Chinese Patients. Sci Rep. 2015 Aug 27; 5:13439. PMID: 26310451.
    Citations: 8     Fields:    Translation:Humans
  22. Gonzalez G, Huang Q, Mashimo H. Characterization of oncocytes in deep esophageal glands. Dis Esophagus. 2016 Aug; 29(6):670-80. PMID: 26245938.
    Citations: 4     Fields:    Translation:HumansCells
  23. Fang C, Huang Q, Lu L, Shi J, Sun Q, Xu GF, Gold J, Mashimo H, Zou XP. Risk factors of early proximal gastric carcinoma in Chinese diagnosed using WHO criteria. J Dig Dis. 2015 Jun; 16(6):327-36. PMID: 25754397.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  24. Liang K, Traverso G, Lee HC, Ahsen OO, Wang Z, Potsaid B, Giacomelli M, Jayaraman V, Barman R, Cable A, Mashimo H, Langer R, Fujimoto JG. Ultrahigh speed en face OCT capsule for endoscopic imaging. Biomed Opt Express. 2015 Apr 01; 6(4):1146-63. PMID: 25909001.
    Citations: 9     
  25. Niadu, H., Huang, Q., Mashimo, H. Gastric Antral Vascular Ectasia: The Evolution of Therapeutic Modalities. Endoscopy International Open. 2015; 02(02):E67-E73.
  26. Tsai TH, Lee HC, Ahsen OO, Liang K, Giacomelli MG, Potsaid BM, Tao YK, Jayaraman V, Figueiredo M, Huang Q, Cable AE, Fujimoto J, Mashimo H. Ultrahigh speed endoscopic optical coherence tomography for gastroenterology. Biomed Opt Express. 2014 Dec 01; 5(12):4387-404. PMID: 25574446.
    Citations: 9     
  27. Bennett M, Mashimo H. Molecular markers and imaging tools to identify malignant potential in Barrett's esophagus. World J Gastrointest Pathophysiol. 2014 Nov 15; 5(4):438-49. PMID: 25400987.
    Citations: 4     
  28. Ahsen OO, Lee HC, Giacomelli MG, Wang Z, Liang K, Tsai TH, Potsaid B, Mashimo H, Fujimoto JG. Correction of rotational distortion for catheter-based en face OCT and OCT angiography. Opt Lett. 2014 Oct 15; 39(20):5973-6. PMID: 25361133.
    Citations: 11     Fields:    Translation:Humans
  29. Zhou, C., Fujimoto, J.G., Tsai, T.-H., Mashimo, H. . Endoscopic Optical Coherence Tomography and Clinical Applications. In: Optical Coherence Tomography. Ed. Drexler W., Fujimoto J.G. 2014.
  30. Dowli A, Mattar A, Mashimo H, Huang Q, Cohen D, Fisichella PM, Lebenthal A. A pedunculated giant esophageal liposarcoma: a case report and literature review. J Gastrointest Surg. 2014 Dec; 18(12):2208-13. PMID: 25190025.
    Citations: 3     Fields:    Translation:Humans
  31. Bajpai M, Das KM, Lefferts J, Lisovsky M, Mashimo H, Phillips WA, Srivastava A, To H. Molecular epidemiology of and genetic susceptibility to esophageal cancer. Ann N Y Acad Sci. 2014 Sep; 1325:40-8. PMID: 25266013.
    Citations: 1     Fields:    Translation:HumansAnimals
  32. Akiyama J, Komanduri S, Konda VJ, Mashimo H, Noria S, Triadafilopoulos G. Endoscopy for diagnosis and treatment in esophageal cancers: high-technology assessment. Ann N Y Acad Sci. 2014 Sep; 1325:77-88. PMID: 25266017.
    Citations:    Fields:    Translation:HumansAnimals
  33. Tsai TH, Ahsen OO, Lee HC, Liang K, Figueiredo M, Tao YK, Giacomelli MG, Potsaid BM, Jayaraman V, Huang Q, Cable AE, Fujimoto JG, Mashimo H. Endoscopic optical coherence angiography enables 3-dimensional visualization of subsurface microvasculature. Gastroenterology. 2014 Dec; 147(6):1219-21. PMID: 25172015.
    Citations: 15     Fields:    Translation:Humans
  34. Shi J, Sun Q, Xu BY, Yu HP, Zhang YF, Zou XP, Huang L, Gold JS, Mashimo H, Yu CG, Huang Q. Changing trends in the proportions of small (= 2?cm) proximal and non-proximal gastric carcinomas treated at a high-volume tertiary medical center in China. J Dig Dis. 2014 Jul; 15(7):359-66. PMID: 24720626.
    Citations: 5     Fields:    Translation:Humans
  35. Rustagi T, Corbett FS, Mashimo H. Treatment of chronic radiation proctopathy with radiofrequency ablation (with video). Gastrointest Endosc. 2015 Feb; 81(2):428-36. PMID: 24973172.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  36. Naidu H, Huang Q, Mashimo H. Gastric antral vascular ectasia: the evolution of therapeutic modalities. Endosc Int Open. 2014 Jun; 2(2):E67-73. PMID: 26135263.
    Citations: 5     
  37. Tsai TH, Fujimoto JG, Mashimo H. Endoscopic Optical Coherence Tomography for Clinical Gastroenterology. Diagnostics (Basel). 2014 May 05; 4(2):57-93. PMID: 26852678.
    Citations: 3     
  38. Chaudhury, A., Mashimo, H. Current Diagnosis and Treatment in Gastroenterology, Hepatology and Endoscopy. Ed. Greenberger, N. J. Oropharyngeal and Esophageal Motility Disorders, Chapter 13. 2014.
  39. Rustagi, T., Mashimo, H. . Textbook of Internal Medicine--An Intensive Board Review with 1000 MCQs. Ed. Baliga R.R. Disorders of the Esophagus. 2014.
  40. Franciosa M, Mashimo H. Stretta radiofrequency treatment for GERD: a safe and effective modality. Am J Gastroenterol. 2013 Oct; 108(10):1654-5. PMID: 24091508.
    Citations: 4     Fields:    Translation:Humans
  41. Locke GR, Horwhat J, Mashimo H, Savarino E, Zentilin P, Savarino V, Zerbib F, Armbruster SP, Wong RK, Moawad F. Endotherapy for and tailored approaches to treating GERD, and refractory GERD. Ann N Y Acad Sci. 2013 Oct; 1300:166-186. PMID: 24117641.
    Citations: 5     Fields:    Translation:Humans
  42. Franciosa M, Triadafilopoulos G, Mashimo H. Stretta Radiofrequency Treatment for GERD: A Safe and Effective Modality. Gastroenterol Res Pract. 2013; 2013:783815. PMID: 24078808.
    Citations: 6     
  43. Chan WW, Mashimo H. Lubiprostone Increases Small Intestinal Smooth Muscle Contractions Through a Prostaglandin E Receptor 1 (EP1)-mediated Pathway. J Neurogastroenterol Motil. 2013 Jul; 19(3):312-8. PMID: 23875097.
    Citations: 10     
  44. Mashimo H. Subsquamous intestinal metaplasia after ablation of Barrett's esophagus: frequency and importance. Curr Opin Gastroenterol. 2013 Jul; 29(4):454-9. PMID: 23674187.
    Citations: 10     Fields:    Translation:Humans
  45. Basavappa M, Weinberg A, Huang Q, Mashimo H. Markers suggest reduced malignant potential of subsquamous intestinal metaplasia compared with Barrett's esophagus. Dis Esophagus. 2014 Apr; 27(3):262-6. PMID: 23796148.
    Citations: 3     Fields:    Translation:Humans
  46. Tsai TH, Potsaid B, Tao YK, Jayaraman V, Jiang J, Heim PJ, Kraus MF, Zhou C, Hornegger J, Mashimo H, Cable AE, Fujimoto JG. Ultrahigh speed endoscopic optical coherence tomography using micromotor imaging catheter and VCSEL technology. Biomed Opt Express. 2013 Jul 01; 4(7):1119-32. PMID: 23847737.
    Citations: 25     
  47. Sun Q, Huang Q, Feng AN, Fan XS, Wu HY, Mashimo H, Zhou Q, Chen J, Lauwers GY. Columnar-lined esophagus in Chinese patients with proximal gastric carcinomas. J Dig Dis. 2013 Jan; 14(1):22-8. PMID: 23134360.
    Citations: 1     Fields:    Translation:HumansCells
  48. Tsai TH, Zhou C, Tao YK, Lee HC, Ahsen OO, Figueiredo M, Kirtane T, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Structural markers observed with endoscopic 3-dimensional optical coherence tomography correlating with Barrett's esophagus radiofrequency ablation treatment response (with videos). Gastrointest Endosc. 2012 Dec; 76(6):1104-12. PMID: 22831857.
    Citations: 20     Fields:    Translation:Humans
  49. Zhang YF, Shi J, Yu HP, Feng AN, Fan XS, Lauwers GY, Mashimo H, Gold JS, Chen G, Huang Q. Factors predicting survival in patients with proximal gastric carcinoma involving the esophagus. World J Gastroenterol. 2012 Jul 21; 18(27):3602-9. PMID: 22826627.
    Citations: 11     Fields:    Translation:Humans
  50. Tsai TH, Zhou C, Lee HC, Tao YK, Ahsen OO, Figueiredo M, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Comparison of Tissue Architectural Changes between Radiofrequency Ablation and Cryospray Ablation in Barrett's Esophagus Using Endoscopic Three-Dimensional Optical Coherence Tomography. Gastroenterol Res Pract. 2012; 2012:684832. PMID: 22844274.
    Citations: 6     
  51. Huang Q, Shi J, Sun Q, Fan X, Feng A, Wu H, Zhou Q, Yu C, Mashimo H, Lauwers GY. Distal esophageal carcinomas in Chinese patients vary widely in histopathology, but adenocarcinomas remain rare. Hum Pathol. 2012 Dec; 43(12):2138-48. PMID: 22658274.
    Citations: 7     Fields:    Translation:Humans
  52. Zhou C, Kirtane T, Tsai TH, Lee HC, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Cervical inlet patch-optical coherence tomography imaging and clinical significance. World J Gastroenterol. 2012 May 28; 18(20):2502-10. PMID: 22654447.
    Citations: 4     Fields:    Translation:Humans
  53. Zhou C, Tsai TH, Lee HC, Kirtane T, Figueiredo M, Tao YK, Ahsen OO, Adler DC, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos). Gastrointest Endosc. 2012 Jul; 76(1):32-40. PMID: 22482920.
    Citations: 32     Fields:    Translation:Humans
  54. Zhou C, Kirtane T, Tsai TH, Lee HC, Adler DC, Schmitt J, Huang Q, Fujimoto JG, Mashimo H. Three-dimensional endoscopic optical coherence tomography imaging of cervical inlet patch. Gastrointest Endosc. 2012 Mar; 75(3):675-7; discussion 677. PMID: 22341118.
    Citations: 2     Fields:    Translation:Humans
  55. Rustagi T, Mashimo H. Endoscopic management of chronic radiation proctitis. World J Gastroenterol. 2011 Nov 07; 17(41):4554-62. PMID: 22147960.
    Citations: 21     Fields:    Translation:HumansPHPublic Health
  56. Souza RF, Schwartz RE, Mashimo H. Esophageal stem cells and 3D-cell culture models. Ann N Y Acad Sci. 2011 Sep; 1232:316-22. PMID: 21950821.
    Citations: 2     Fields:    Translation:HumansCells
  57. Hershcovici T, Mashimo H, Fass R. The lower esophageal sphincter. Neurogastroenterol Motil. 2011 Sep; 23(9):819-30. PMID: 21711416.
    Citations: 21     Fields:    Translation:HumansAnimals
  58. Shaheen NJ, Overholt BF, Sampliner RE, Wolfsen HC, Wang KK, Fleischer DE, Sharma VK, Eisen GM, Fennerty MB, Hunter JG, Bronner MP, Goldblum JR, Bennett AE, Mashimo H, Rothstein RI, Gordon SR, Edmundowicz SA, Madanick RD, Peery AF, Muthusamy VR, Chang KJ, Kimmey MB, Spechler SJ, Siddiqui AA, Souza RF, Infantolino A, Dumot JA, Falk GW, Galanko JA, Jobe BA, Hawes RH, Hoffman BJ, Sharma P, Chak A, Lightdale CJ. Durability of radiofrequency ablation in Barrett's esophagus with dysplasia. Gastroenterology. 2011 Aug; 141(2):460-8. PMID: 21679712.
    Citations: 109     Fields:    Translation:Humans
  59. Huang Q, Shi J, Feng A, Fan X, Zhang L, Mashimo H, Cohen D, Lauwers G. Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System. Mod Pathol. 2011 Jan; 24(1):138-46. PMID: 20852593.
    Citations: 18     Fields:    Translation:Humans
  60. Mashimo, H., Goyal, R.K. GI Motility Online. Eds. R.K. Goyal, R. Shaker. Physiology of Esophageal Motility. Chapter 3. 2010. View Publication.
  61. Aguirre AD, Chen Y, Bryan B, Mashimo H, Huang Q, Connolly JL, Fujimoto JG. Cellular resolution ex vivo imaging of gastrointestinal tissues with optical coherence microscopy. J Biomed Opt. 2010 Jan-Feb; 15(1):016025. PMID: 20210470.
    Citations: 12     Fields:    Translation:Humans
  62. Adler DC, Zhou C, Tsai TH, Lee HC, Becker L, Schmitt JM, Huang Q, Fujimoto JG, Mashimo H. Three-dimensional optical coherence tomography of Barrett's esophagus and buried glands beneath neosquamous epithelium following radiofrequency ablation. Endoscopy. 2009 Sep; 41(9):773-6. PMID: 19746317.
    Citations: 24     Fields:    Translation:Humans
  63. Becker L, Huang Q, Mashimo H. Lgr5, an intestinal stem cell marker, is abnormally expressed in Barrett's esophagus and esophageal adenocarcinoma. Dis Esophagus. 2010 Feb; 23(2):168-74. PMID: 19549212.
    Citations: 30     Fields:    Translation:HumansCells
  64. Shaheen NJ, Sharma P, Overholt BF, Wolfsen HC, Sampliner RE, Wang KK, Galanko JA, Bronner MP, Goldblum JR, Bennett AE, Jobe BA, Eisen GM, Fennerty MB, Hunter JG, Fleischer DE, Sharma VK, Hawes RH, Hoffman BJ, Rothstein RI, Gordon SR, Mashimo H, Chang KJ, Muthusamy VR, Edmundowicz SA, Spechler SJ, Siddiqui AA, Souza RF, Infantolino A, Falk GW, Kimmey MB, Madanick RD, Chak A, Lightdale CJ. Radiofrequency ablation in Barrett's esophagus with dysplasia. N Engl J Med. 2009 May 28; 360(22):2277-88. PMID: 19474425.
    Citations: 307     Fields:    Translation:Humans
  65. Becker L, Mashimo H. Further promise of stem cells therapies in the enteric nervous system. Gastroenterology. 2009 Jun; 136(7):2055-8. PMID: 19409291.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  66. Adler DC, Zhou C, Tsai TH, Schmitt J, Huang Q, Mashimo H, Fujimoto JG. Three-dimensional endomicroscopy of the human colon using optical coherence tomography. Opt Express. 2009 Jan 19; 17(2):784-96. PMID: 19158891.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  67. Zhou C, Adler DC, Becker L, Chen Y, Tsai TH, Figueiredo M, Schmitt JM, Fujimoto JG, Mashimo H. Effective treatment of chronic radiation proctitis using radiofrequency ablation. Therap Adv Gastroenterol. 2009 Jan 01; 2(3):149-156. PMID: 20593010.
    Citations: 31     
  68. Becker L, Huang Q, Mashimo H. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. ScientificWorldJournal. 2008 Nov 23; 8:1168-76. PMID: 19030762.
    Citations: 39     Fields:    Translation:HumansCells
  69. Sivarao DV, Mashimo H, Goyal RK. Pyloric sphincter dysfunction in nNOS-/- and W/Wv mutant mice: animal models of gastroparesis and duodenogastric reflux. Gastroenterology. 2008 Oct; 135(4):1258-66. PMID: 18640116.
    Citations: 25     Fields:    Translation:Animals
  70. Chen Y, Aguirre AD, Hsiung PL, Huang SW, Mashimo H, Schmitt JM, Fujimoto JG. Effects of axial resolution improvement on optical coherence tomography (OCT) imaging of gastrointestinal tissues. Opt Express. 2008 Feb 18; 16(4):2469-85. PMID: 18542326.
    Citations: 9     Fields:    Translation:Humans
  71. Goyal, R.K., Chaudhury, A., Mashimo, H. . Oropharyngeal and Esophageal Motility Disorders, Chapter 13. 2008.
  72. Zhang Y, Mashimo H, Paterson WG. Regional differences in nitrergic innervation of the smooth muscle of murine lower oesophageal sphincter. Br J Pharmacol. 2008 Feb; 153(3):517-27. PMID: 18037919.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  73. Chen Y, Aguirre AD, Hsiung PL, Desai S, Herz PR, Pedrosa M, Huang Q, Figueiredo M, Huang SW, Koski A, Schmitt JM, Fujimoto JG, Mashimo H. Ultrahigh resolution optical coherence tomography of Barrett's esophagus: preliminary descriptive clinical study correlating images with histology. Endoscopy. 2007 Jul; 39(7):599-605. PMID: 17611914.
    Citations: 50     Fields:    Translation:Humans
  74. Hiroshi Mashimo and Raj K. Goyal. “Smart balloon catheters for diagnosis and therapy of lumen narrowing.”. 2006.
  75. Hiroshi Mashimo and Satish Singh. “Engineered stem cells delivered directly into digestive organs for drug delivery, gene therapy, cell replacement, research and diagnostic applications.”. 2006.
  76. Hsiung PL, Pantanowitz L, Aguirre AD, Chen Y, Phatak D, Ko TH, Bourquin S, Schnitt SJ, Raza S, Connolly JL, Mashimo H, Fujimoto JG. Ultrahigh-resolution and 3-dimensional optical coherence tomography ex vivo imaging of the large and small intestines. Gastrointest Endosc. 2005 Oct; 62(4):561-74. PMID: 16185971.
    Citations: 12     Fields:    Translation:Humans
  77. Terauchi A, Kobayashi D, Mashimo H. Distinct roles of nitric oxide synthases and interstitial cells of Cajal in rectoanal relaxation. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G291-9. PMID: 15845873.
    Citations: 15     Fields:    Translation:Animals
  78. Mashimo H, Wagh MS, Goyal RK. Surveillance and screening for Barrett esophagus and adenocarcinoma. J Clin Gastroenterol. 2005 Apr; 39(4 Suppl 2):S33-41. PMID: 15758657.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  79. Herz P, Chen Y, Aguirre A, Fujimoto J, Mashimo H, Schmitt J, Koski A, Goodnow J, Petersen C. Ultrahigh resolution optical biopsy with endoscopic optical coherence tomography. Opt Express. 2004 Jul 26; 12(15):3532-42. PMID: 19483882.
    Citations: 15     Fields:    
  80. Vallance BA, Dijkstra G, Qiu B, van der Waaij LA, van Goor H, Jansen PL, Mashimo H, Collins SM. Relative contributions of NOS isoforms during experimental colitis: endothelial-derived NOS maintains mucosal integrity. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G865-74. PMID: 15217783.
    Citations: 16     Fields:    Translation:AnimalsCells
  81. Beck PL, Xavier R, Wong J, Ezedi I, Mashimo H, Mizoguchi A, Mizoguchi E, Bhan AK, Podolsky DK. Paradoxical roles of different nitric oxide synthase isoforms in colonic injury. Am J Physiol Gastrointest Liver Physiol. 2004 Jan; 286(1):G137-47. PMID: 14665440.
    Citations: 27     Fields:    Translation:AnimalsCells
  82. Chang HY, Mashimo H, Goyal RK. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am J Physiol Gastrointest Liver Physiol. 2003 Mar; 284(3):G357-66. PMID: 12576302.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  83. Sivarao DV, Mashimo HL, Thatte HS, Goyal RK. Lower esophageal sphincter is achalasic in nNOS(-/-) and hypotensive in W/W(v) mutant mice. Gastroenterology. 2001 Jul; 121(1):34-42. PMID: 11438492.
    Citations: 45     Fields:    Translation:Animals
  84. Li XD, Boppart SA, Van Dam J, Mashimo H, Mutinga M, Drexler W, Klein M, Pitris C, Krinsky ML, Brezinski ME, Fujimoto JG. Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett's esophagus. Endoscopy. 2000 Dec; 32(12):921-30. PMID: 11147939.
    Citations: 47     Fields:    Translation:Humans
  85. Mashimo H, Kjellin A, Goyal RK. Gastric stasis in neuronal nitric oxide synthase-deficient knockout mice. Gastroenterology. 2000 Sep; 119(3):766-73. PMID: 10982771.
    Citations: 42     Fields:    Translation:Animals
  86. Mashimo H, Goyal RK. Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice. Am J Physiol. 1999 10; 277(4):G745-50. PMID: 10516139.
    Citations: 27     Fields:    Translation:AnimalsCells
  87. Kim CD, Goyal RK, Mashimo H. Neuronal NOS provides nitrergic inhibitory neurotransmitter in mouse lower esophageal sphincter. Am J Physiol. 1999 08; 277(2):G280-4. PMID: 10444441.
    Citations: 16     Fields:    Translation:Animals
  88. Koh TJ, Goldenring JR, Ito S, Mashimo H, Kopin AS, Varro A, Dockray GJ, Wang TC. Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice. Gastroenterology. 1997 Sep; 113(3):1015-25. PMID: 9287997.
    Citations: 47     Fields:    Translation:AnimalsCells
  89. Valenzuela D, Han X, Mende U, Fankhauser C, Mashimo H, Huang P, Pfeffer J, Neer EJ, Fishman MC. G alpha(o) is necessary for muscarinic regulation of Ca2+ channels in mouse heart. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1727-32. PMID: 9050846.
    Citations: 34     Fields:    Translation:AnimalsCells
  90. Mashimo H, Wu DC, Podolsky DK, Fishman MC. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science. 1996 Oct 11; 274(5285):262-5. PMID: 8824194.
    Citations: 152     Fields:    Translation:AnimalsCells
  91. Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996 Oct 10; 383(6600):525-8. PMID: 8849723.
    Citations: 119     Fields:    Translation:AnimalsCells
  92. Mashimo H, He XD, Huang PL, Fishman MC, Goyal RK. Neuronal constitutive nitric oxide synthase is involved in murine enteric inhibitory neurotransmission. J Clin Invest. 1996 Jul 01; 98(1):8-13. PMID: 8690808.
    Citations: 32     Fields:    Translation:AnimalsCells
  93. Carpenter C, Honkanen AA, Mashimo H, Goss KA, Huang P, Fishman MC, Asaad M, Dorso CR, Cheung H. Renal abnormalities in mutant mice. Nature. 1996 Mar 28; 380(6572):292. PMID: 8598926.
    Citations: 3     Fields:    Translation:Animals
  94. Mashimo H, He XD, Huang PL, Fishman MC, Goyal RK . Evidence for prejunctional action of VIP in nitric oxide-mediated inhibitory neurotransmission. Digestive Disease and Sciences. 1996; 41:1888.
  95. Huang PL, Huang Z, Mashimo H, Bloch KD, Moskowitz MA, Bevan JA, Fishman MC. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature. 1995 Sep 21; 377(6546):239-42. PMID: 7545787.
    Citations: 414     Fields:    Translation:Animals
  96. Mashimo H, Podolsky DK, Fishman MC. Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 05; 210(1):31-7. PMID: 7741746.
    Citations: 10     Fields:    Translation:AnimalsCells
  97. Strittmatter SM, Fankhauser C, Huang PL, Mashimo H, Fishman MC. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell. 1995 Feb 10; 80(3):445-52. PMID: 7859286.
    Citations: 78     Fields:    Translation:AnimalsCells
  98. Mashimo, H., .Podolsky, D.K., Fishman, M.C. . Structure and expression of murine Intestinal Trefoil Factor: High evolutionary conservation and postnatal expression. Gastroenterology. 1995; 108:A738.
  99. Mashimo H, Chorney MJ, Pontarotti P, Fisher DA, Hood L, Nathenson SG. Nucleotide sequence of the BALB/c H-2T region gene, T3d. Immunogenetics. 1992; 36(5):326-32. PMID: 1339405.
    Citations: 3     Fields:    Translation:AnimalsCells
  100. Zeff RA, Nakagawa M, Mashimo H, Gopas J, Nathenson SG. Failure of cell surface expression of a class I major histocompatibility antigen caused by somatic point mutation. Transplantation. 1990 Apr; 49(4):803-8. PMID: 2326874.
    Citations: 3     Fields:    Translation:AnimalsCells
  101. Chorney MJ, Mashimo H, Bushkin Y, Nathenson SG. Characterization of the thymus leukemia (TL) product encoded by the BALB/c T3c gene by DNA-mediated gene transfer. Comparison to the T13c product and BALB/c leukemia TL. J Immunol. 1989 Dec 01; 143(11):3762-8. PMID: 2584718.
    Citations: 7     Fields:    Translation:Animals
  102. Hiroshi Mashimo. "Conservation and diversity in the murine major histocompatibility complex: studies on the T3 subset of the TLA genes.". 1988.
  103. Zeff RA, Kumar PA, Mashimo H, Nakagawa M, McCue B, Borriello F, Kesari K, Geliebter J, Hemmi S, Pfaffenbach G, et al. Somatic cell variants of the murine major histocompatibility complex. Immunol Res. 1987; 6(1-2):133-44. PMID: 3305735.
    Citations: 1     Fields:    Translation:AnimalsCells
  104. Mashimo, H . Studies on the T3 subset of genes in the Tla region of the Major Histocompatibility Complex. The Einstein Quarterly J Biol Med. 1987; 5:39-40.
  105. Pontarotti PA, Mashimo H, Zeff RA, Fisher DA, Hood L, Mellor A, Flavell RA, Nathenson SG. Conservation and diversity in the class I genes of the major histocompatibility complex: sequence analysis of a Tlab gene and comparison with a Tlac gene. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1782-6. PMID: 3456611.
    Citations: 29     Fields:    Translation:AnimalsCells
  106. Geliebter, J., Ajit Kumar, P., Borriello, F., Hemmi, S., Kesari, K., Mashimo, H., Mc Govern, D., Nakagawa, M., Palmieri-Lehner, E., Pontarotti, P., Pfaffenbach, G.M., Raval, R., Trojnacki, J., Zeff, R.A. and Nathenson, S.G. Polymorphism and diversity in the murine class I gene family: a study of spontaneous mutants. Evolution and Vertebrate Immunity, Kelsoe, G. and Schulze, D.H. 1986; 315-327.
  107. Geliebter, J., Ajit Kumar, P., Borriello, F., Hemmi, S., Kesari, K., Mashimo, H., Nakagawa, M., Pontarotti, P., Pfaffenbach, G.M., Zeff, R.A. and Nathenson, S.G. The use of class I mutants to study polymorphism and diversity in the MHC. Molecular Biology, Schacter, B. 1986; 43-50.
  108. Zeff, R.A., Mashimo, H., Gopas, J., Borriello, F., and Nathenson, S.G. . Somatic variants of the Kb gene provide an approach for the study of the molecular and structural requirements for class I expression. Fifth HLA and H-2 Cloning Workshop. 1986; 5:88.
  109. Pontarotti, P., Mashimo, H., Zeff, R., Fisher, D., Hood, L., Mellor, A., Flavell, R., Nathenson, S. . Diversity in the class I genes in the major histocompatibility complex: sequence analysis of the Tlab gene and comparison with a Tlac gene. Fourth HLA and H-2 Cloning Workshop. 1985; 4:49.
  110. Nathenson, S.G., Geliebter, J., Geier, S.S., Mashimo, H., Hemmi, S., Kumar, A., Mc Govern, D., Nakagawa, M., Pfaffenbach, G., Pontarotti, P. and Zeff, R. The study of H-2 major histocompatibility complex mutants reveals structure-function relationships and mechanisms of generation of diversity and polymorphism. ICSU Short Report 2, Advances in Gene Technology: Molecular Biology of the Immune System. 1985; 37-40.
  111. Zeff, R.A., Geier, S.S., Gopas, J., Geliebter, J., Schulze, D.H., Pease, L.R., Pfaffenbach, G.M., Pontarotti, P., Mashimo, H., McGovern, D.A. and Nathenson, S.G. Mutants of the murine major histocompatibility complex: structural analysis of in vivo and in vitro H-2Kb variants. Cell Biology of the Major Histocompatibility Complex, eds., Pernis, B. and Vogel, H.J. 1985; 41-49.
  112. Mashimo, H., Pontarotti, P., Rosenblatt, B.R., Fisher, D., Hood, L., and Nathenson, S.G. Isolation and DNA sequence analysis of a Tla gene of a Tlab haplotype. Federation Proceedings Abstracts. 1984; 44(6):1596.
  113. Pease, L.R., Schulze, DH., Geliebter, J., Geier, S.S., Pfaffenbach, G.M., Yokoyama, K., Zeff, R.A., Rosenblatt, B.R., Mashimo, H. McGovern, D., Trojnacki, J., Flocco, M. and Nathenson, S.G. . Studies on Class I MHC mutants provide evidence that diversity and polymorphism are generated by a copy mechanism. Second Meeting on Cloning of the HLA and H-2 Regions. 1983; 11.
  114. Hiroshi Mashimo. "Characterization of novel Class I Major Histocompatibility-like proteins associated with thymus leukemia.". 1981.
  115. Cotner T, Mashimo H, Kung PC, Goldstein G, Strominger JL. Human T cell surface antigens bearing a structural relationship to HLA antigens. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3858-62. PMID: 6167992.
    Citations: 17     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.