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profileHoward Michael Goodman, Ph.D.

TitleProfessor of Genetics
InstitutionMassachusetts General Hospital
DepartmentGenetics
AddressMassachusetts General Hospital
Dept of Molecular Bio, Wellman 11
55 Fruit St
Boston MA 02114
Phone617/726-5933
Fax617/726-3535
vCardDownload vCard (login for email)
Other Positions
TitleHead of the Department of Molecular Biology At Massachusetts General Hospital
InstitutionMassachusetts General Hospital
DepartmentGenetics


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lazar G, Goodman HM. MAX1, a regulator of the flavonoid pathway, controls vegetative axillary bud outgrowth in Arabidopsis. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):472-6. PMID: 16387852; PMCID: PMC1324789.
  2. Hsieh MH, Goodman HM. The Arabidopsis IspH homolog is involved in the plastid nonmevalonate pathway of isoprenoid biosynthesis. Plant Physiol. 2005 Jun; 138(2):641-53. PMID: 15863698; PMCID: PMC1150385.
  3. Shen B, Goodman HM. Uridine addition after microRNA-directed cleavage. Science. 2004 Nov 05; 306(5698):997. PMID: 15528436.
    View in: PubMed
  4. Lin Y, Cluette-Brown JE, Goodman HM. The peroxisome deficient Arabidopsis mutant sse1 exhibits impaired fatty acid synthesis. Plant Physiol. 2004 Jun; 135(2):814-27. PMID: 15173561; PMCID: PMC514117.
  5. He J, Baldini RL, D├ęziel E, Saucier M, Zhang Q, Liberati NT, Lee D, Urbach J, Goodman HM, Rahme LG. The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2530-5. PMID: 14983043; PMCID: PMC356984.
  6. Hsieh MH, Goodman HM. Molecular characterization of a novel gene family encoding ACT domain repeat proteins in Arabidopsis. Plant Physiol. 2002 Dec; 130(4):1797-806. PMID: 12481063; PMCID: PMC166691.
  7. Lancien M, Martin M, Hsieh MH, Leustek T, Goodman H, Coruzzi GM. Arabidopsis glt1-T mutant defines a role for NADH-GOGAT in the non-photorespiratory ammonium assimilatory pathway. Plant J. 2002 Feb; 29(3):347-58. PMID: 11844111.
    View in: PubMed
  8. Lazar G, Goodman HM. The Arabidopsis splicing factor SR1 is regulated by alternative splicing. Plant Mol Biol. 2000 Mar; 42(4):571-81. PMID: 10809003.
    View in: PubMed
  9. Lin Y, Sun L, Nguyen LV, Rachubinski RA, Goodman HM. The Pex16p homolog SSE1 and storage organelle formation in Arabidopsis seeds. Science. 1999 Apr 09; 284(5412):328-30. PMID: 10195899.
    View in: PubMed
  10. Wang ML, Belmonte S, Kim U, Dolan M, Morris JW, Goodman HM. A cluster of ABA-regulated genes on Arabidopsis thaliana BAC T07M07. Genome Res. 1999 Apr; 9(4):325-33. PMID: 10207155.
    View in: PubMed
  11. Wang ML, Huang L, Bongard-Pierce DK, Belmonte S, Zachgo EA, Morris JW, Dolan M, Goodman HM. Construction of an approximately 2 Mb contig in the region around 80 cM of Arabidopsis thaliana chromosome 2. Plant J. 1997 Sep; 12(3):711-30. PMID: 9351255.
    View in: PubMed
  12. Tague BW, Gallant P, Goodman HM. Expression analysis of an Arabidopsis C2H2 zinc finger protein gene. Plant Mol Biol. 1996 Dec; 32(5):785-96. PMID: 8980531.
    View in: PubMed
  13. Hornstein MD, Goodman HM, Thomas PP, Knapp RC, Harlow BL. Use of a second-generation CA125 assay in gynecologic patients. Gynecol Obstet Invest. 1996; 42(3):196-200. PMID: 8938474.
    View in: PubMed
  14. Zachgo EA, Wang ML, Dewdney J, Bouchez D, Camilleri C, Belmonte S, Huang L, Dolan M, Goodman HM. A physical map of chromosome 2 of Arabidopsis thaliana. Genome Res. 1996 Jan; 6(1):19-25. PMID: 8681135.
    View in: PubMed
  15. Goodman HM, Ecker JR, Dean C. The genome of Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10831-5. PMID: 7479893; PMCID: PMC40525.
  16. Lazar G, Schaal T, Maniatis T, Goodman HM. Identification of a plant serine-arginine-rich protein similar to the mammalian splicing factor SF2/ASF. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7672-6. PMID: 7644475; PMCID: PMC41207.
  17. Hwang I, Goodman HM. An Arabidopsis thaliana root-specific kinase homolog is induced by dehydration, ABA, and NaCl. Plant J. 1995 Jul; 8(1):37-43. PMID: 7655506.
    View in: PubMed
  18. Tague BW, Goodman HM. Characterization of a family of Arabidopsis zinc finger protein cDNAs. Plant Mol Biol. 1995 May; 28(2):267-79. PMID: 7599312.
    View in: PubMed
  19. Zhang H, Wang J, Hwang I, Goodman HM. Isolation and expression of an Arabidopsis 14-3-3-like protein gene. Biochim Biophys Acta. 1995 Apr 06; 1266(1):113-6. PMID: 7718616.
    View in: PubMed
  20. Chiang HH, Hwang I, Goodman HM. Isolation of the Arabidopsis GA4 locus. Plant Cell. 1995 Feb; 7(2):195-201. PMID: 7756830; PMCID: PMC160775.
  21. Muto MG, Welch WR, Mok SC, Bandera CA, Fishbaugh PM, Tsao SW, Lau CC, Goodman HM, Knapp RC, Berkowitz RS. Evidence for a multifocal origin of papillary serous carcinoma of the peritoneum. Cancer Res. 1995 Feb 01; 55(3):490-2. PMID: 7834614.
    View in: PubMed
  22. Zhang H, Wang J, Goodman HM. Expression of the Arabidopsis Gene Akr Coincides with Chloroplast Development. Plant Physiol. 1994 Dec; 106(4):1261-1267. PMID: 12232406.
    View in: PubMed
  23. Zhang H, Wang J, Goodman HM. Differential expression in Arabidopsis of Lhca2, a PSI cab gene. Plant Mol Biol. 1994 Jun; 25(3):551-7. PMID: 8049378.
    View in: PubMed
  24. Wang J, Zhang H, Goodman HM. An Arabidopsis cab gene homologous to Cab-8 of tomato. Plant Physiol. 1994 Jan; 104(1):297. PMID: 8115553; PMCID: PMC159195.
  25. Dewdney J, Conley TR, Shih MC, Goodman HM. Effects of blue and red light on expression of nuclear genes encoding chloroplast glyceraldehyde-3-phosphate dehydrogenase of Arabidopsis thaliana. Plant Physiol. 1993 Dec; 103(4):1115-21. PMID: 8290625; PMCID: PMC159096.
  26. Shirley BW, Goodman HM. An Arabidopsis gene homologous to mammalian and insect genes encoding the largest proteasome subunit. Mol Gen Genet. 1993 Dec; 241(5-6):586-94. PMID: 8264533.
    View in: PubMed
  27. Hwang I, Goodman HM. Cloning of an Arabidopsis ribosomal protein S28 cDNA. Plant Physiol. 1993 Aug; 102(4):1357-8. PMID: 8278557; PMCID: PMC158933.
  28. Lazar G, Zhang H, Goodman HM. The origin of the bifunctional dihydrofolate reductase-thymidylate synthase isogenes of Arabidopsis thaliana. Plant J. 1993 May; 3(5):657-68. PMID: 8374616.
    View in: PubMed
  29. Tsao SW, Mok CH, Knapp RC, Oike K, Muto MG, Welch WR, Goodman HM, Sheets EE, Berkowitz RS, Lau CC. Molecular genetic evidence of a unifocal origin for human serous ovarian carcinomas. Gynecol Oncol. 1993 Jan; 48(1):5-10. PMID: 8423021.
    View in: PubMed
  30. Zhang H, Scheirer DC, Fowle WH, Goodman HM. Expression of antisense or sense RNA of an ankyrin repeat-containing gene blocks chloroplast differentiation in arabidopsis. Plant Cell. 1992 Dec; 4(12):1575-88. PMID: 1281700; PMCID: PMC160243.
  31. Kubasek WL, Shirley BW, McKillop A, Goodman HM, Briggs W, Ausubel FM. Regulation of Flavonoid Biosynthetic Genes in Germinating Arabidopsis Seedlings. Plant Cell. 1992 Oct; 4(10):1229-1236. PMID: 12297632.
    View in: PubMed
  32. Giraudat J, Hauge BM, Valon C, Smalle J, Parcy F, Goodman HM. Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell. 1992 Oct; 4(10):1251-61. PMID: 1359917; PMCID: PMC160212.
  33. Shih MC, Heinrich P, Goodman HM. Cloning and chromosomal mapping of nuclear genes encoding chloroplast and cytosolic glyceraldehyde-3-phosphate-dehydrogenase from Arabidopsis thaliana. Gene. 1992 Oct 01; 119(2):317-9. PMID: 1398114.
    View in: PubMed
  34. Goodman HM, Harlow BL, Sheets EE, Muto MG, Brooks S, Steller M, Knapp RC, Berkowitz RS. The role of cytoreductive surgery in the management of stage IV epithelial ovarian carcinoma. Gynecol Oncol. 1992 Sep; 46(3):367-71. PMID: 1526516.
    View in: PubMed
  35. Shirley BW, Hanley S, Goodman HM. Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell. 1992 Mar; 4(3):333-47. PMID: 1354004; PMCID: PMC160133.
  36. Sun T, Goodman HM, Ausubel FM. Cloning the Arabidopsis GA1 Locus by Genomic Subtraction. Plant Cell. 1992 Feb; 4(2):119-128. PMID: 12297643.
    View in: PubMed
  37. Hwang I, Kohchi T, Hauge BM, Goodman HM, Schmidt R, Cnops G, Dean C, Gibson S, Iba K, Lemieux B, et al. Identification and map position of YAC clones comprising one-third of the Arabidopsis genome. Plant J. 1991 Nov; 1(3):367-74. PMID: 1844889.
    View in: PubMed
  38. Peterman TK, Goodman HM. The glutamine synthetase gene family of Arabidopsis thaliana: light-regulation and differential expression in leaves, roots and seeds. Mol Gen Genet. 1991 Nov; 230(1-2):145-54. PMID: 1684022.
    View in: PubMed
  39. Tsao SW, Mok CH, Oike K, Muto M, Goodman HM, Sheets EE, Berkowitz RS, Knapp RC, Lau CC. Involvement of p53 gene in the allelic deletion of chromosome 17p in human ovarian tumors. Anticancer Res. 1991 Nov-Dec; 11(6):1975-82. PMID: 1776830.
    View in: PubMed
  40. Shih MC, Heinrich P, Goodman HM. Cloning and chromosomal mapping of nuclear genes encoding chloroplast and cytosolic glyceraldehyde-3-phosphate-dehydrogenase from Arabidopsis thaliana. Gene. 1991 Aug 15; 104(2):133-8. PMID: 1916285.
    View in: PubMed
  41. Zhang H, Hanley S, Goodman HM. Isolation, Characterization, and Chromosomal Location of a New cab Gene from Arabidopsis thaliana. Plant Physiol. 1991 Aug; 96(4):1387-8. PMID: 16668349.
    View in: PubMed
  42. Richards EJ, Goodman HM, Ausubel FM. The centromere region of Arabidopsis thaliana chromosome 1 contains telomere-similar sequences. Nucleic Acids Res. 1991 Jun 25; 19(12):3351-7. PMID: 1648204; PMCID: PMC328334.
  43. Cheng CL, Acedo GN, Dewdney J, Goodman HM, Conkling MA. Differential expression of the two Arabidopsis nitrate reductase genes. Plant Physiol. 1991 May; 96(1):275-9. PMID: 16668164.
    View in: PubMed
  44. Hauge BM, Hanley S, Giraudat J, Goodman HM. Mapping the Arabidopsis genome. Symp Soc Exp Biol. 1991; 45:45-56. PMID: 1688208.
    View in: PubMed
  45. Comb M, Goodman HM. CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res. 1990 Jul 11; 18(13):3975-82. PMID: 1695733; PMCID: PMC331101.
  46. Pfitzner AJ, Pfitzner UM, Goodman HM. Nucleotide sequences of two PR-1 pseudogenes from Nicotiana tabacum cv. Wisconsin 38. Nucleic Acids Res. 1990 Jun 11; 18(11):3404. PMID: 2356132; PMCID: PMC330958.
  47. Ross ME, Evinger MJ, Hyman SE, Carroll JM, Mucke L, Comb M, Reis DJ, Joh TH, Goodman HM. Identification of a functional glucocorticoid response element in the phenylethanolamine N-methyltransferase promoter using fusion genes introduced into chromaffin cells in primary culture. J Neurosci. 1990 Feb; 10(2):520-30. PMID: 2303857.
    View in: PubMed
  48. Goodman HM, Niloff JM, Buttlar CA, Welch WR, Marck A, Feuer EJ, Lahman EA, Jenison E, Knapp RC. Adenocarcinoma of the cervical stump. Gynecol Oncol. 1989 Nov; 35(2):188-92. PMID: 2807009.
    View in: PubMed
  49. Lazar G, Toth I, Haakonsen L, Goodman HM. Coregulation of dihydrofolate reductase and thymidylate synthase in overproducer cell lines of wild carrot. Plant Physiol. 1989 Nov; 91(3):1168-73. PMID: 16667128.
    View in: PubMed
  50. Nam HG, Giraudat J, Den Boer B, Moonan F, Loos W, Hauge BM, Goodman HM. Restriction Fragment Length Polymorphism Linkage Map of Arabidopsis thaliana. Plant Cell. 1989 Jul; 1(7):699-705. PMID: 12359906.
    View in: PubMed
  51. Selden RF, Yun JS, Moore DD, Rowe ME, Malia MA, Wagner TE, Goodman HM. Glucocorticoid regulation of human growth hormone expression in transgenic mice and transiently transfected cells. J Endocrinol. 1989 Jul; 122(1):49-60. PMID: 2769161.
    View in: PubMed
  52. Goodman HM, Buttlar CA, Niloff JM, Welch WR, Marck A, Feuer EJ, Lahman EA, Jenison EL, Knapp RC. Adenocarcinoma of the uterine cervix: prognostic factors and patterns of recurrence. Gynecol Oncol. 1989 May; 33(2):241-7. PMID: 2649424.
    View in: PubMed
  53. Hyman SE, Comb M, Pearlberg J, Goodman HM. An AP-2 element acts synergistically with the cyclic AMP- and phorbol ester-inducible enhancer of the human proenkephalin gene. Mol Cell Biol. 1989 Jan; 9(1):321-4. PMID: 2538722; PMCID: PMC362175.
  54. Comb M, Mermod N, Hyman SE, Pearlberg J, Ross ME, Goodman HM. Proteins bound at adjacent DNA elements act synergistically to regulate human proenkephalin cAMP inducible transcription. EMBO J. 1988 Dec 01; 7(12):3793-805. PMID: 2850173; PMCID: PMC454956.
  55. Shih MC, Heinrich P, Goodman HM. Intron existence predated the divergence of eukaryotes and prokaryotes. Science. 1988 Nov 25; 242(4882):1164-6. PMID: 3055302.
    View in: PubMed
  56. Selden RF, Wagner TE, Blethen S, Yun JS, Rowe ME, Goodman HM. Expression of the human growth hormone variant gene in cultured fibroblasts and transgenic mice. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):8241-5. PMID: 3186721; PMCID: PMC282405.
  57. Cheng CL, Dewdney J, Nam HG, den Boer BG, Goodman HM. A new locus (NIA 1) in Arabidopsis thaliana encoding nitrate reductase. EMBO J. 1988 Nov; 7(11):3309-14. PMID: 2905260; PMCID: PMC454825.
  58. Hyman SE, Comb M, Lin YS, Pearlberg J, Green MR, Goodman HM. A common trans-acting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP. Mol Cell Biol. 1988 Oct; 8(10):4225-33. PMID: 2903436; PMCID: PMC365494.
  59. Shih MC, Goodman HM. Differential light regulated expression of nuclear genes encoding chloroplast and cytosolic glyceraldehyde-3-phosphate dehydrogenase in Nicotiana tabacum. EMBO J. 1988 Apr; 7(4):893-8. PMID: 16453834.
    View in: PubMed
  60. Dunn K, Dickstein R, Feinbaum R, Burnett BK, Peterman TK, Thoidis G, Goodman HM, Ausubel FM. Developmental regulation of nodule-specific genes in alfalfa root nodules. Mol Plant Microbe Interact. 1988 Feb; 1(2):66-74. PMID: 2908768.
    View in: PubMed
  61. Grove JR, Price DJ, Goodman HM, Avruch J. Recombinant fragment of protein kinase inhibitor blocks cyclic AMP-dependent gene transcription. Science. 1987 Oct 23; 238(4826):530-3. PMID: 2821622.
    View in: PubMed
  62. Selden RF, Skoskiewicz MJ, Russell PS, Goodman HM. Regulation of insulin-gene expression. Implications for gene therapy. N Engl J Med. 1987 Oct 22; 317(17):1067-76. PMID: 3309655.
    View in: PubMed
  63. Toth I, Lazar G, Goodman HM. Purification and immunochemical characterization of a dihydrofolate reductase-thymidylate synthase enzyme complex from wild-carrot cells. EMBO J. 1987 Jul; 6(7):1853-8. PMID: 16453780.
    View in: PubMed
  64. Cheng CL, Dewdney J, Kleinhofs A, Goodman HM. Cloning and nitrate induction of nitrate reductase mRNA. Proc Natl Acad Sci U S A. 1986 Sep; 83(18):6825-8. PMID: 16593758.
    View in: PubMed
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