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Philip J Kranzusch, Ph.D.


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  1. DP2GM146250 (KRANZUSCH, PHILIP J) Sep 24, 2021 - Aug 31, 2024
    Discovery of cGAS-like signaling enzymes in innate immunity and disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Duncan-Lowey B, Kranzusch PJ. CBASS phage defense and evolution of antiviral nucleotide signaling. Curr Opin Immunol. 2022 Feb; 74:156-163. PMID: 35123147.
    Citations:    Fields:    
  2. Johnson AG, Wein T, Mayer ML, Duncan-Lowey B, Yirmiya E, Oppenheimer-Shaanan Y, Amitai G, Sorek R, Kranzusch PJ. Bacterial gasdermins reveal an ancient mechanism of cell death. Science. 2022 Jan 14; 375(6577):221-225. PMID: 35025633.
    Citations: 6     Fields:    Translation:Cells
  3. Duncan-Lowey B, McNamara-Bordewick NK, Tal N, Sorek R, Kranzusch PJ. Effector-mediated membrane disruption controls cell death in CBASS antiphage defense. Mol Cell. 2021 12 16; 81(24):5039-5051.e5. PMID: 34784509.
    Citations:    Fields:    Translation:Cells
  4. Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, Sorek R. Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell. 2021 11 11; 184(23):5728-5739.e16. PMID: 34644530.
    Citations: 2     Fields:    Translation:Cells
  5. Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila. Nature. 2021 09; 597(7874):109-113. PMID: 34261127.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  6. Govande AA, Duncan-Lowey B, Eaglesham JB, Whiteley AT, Kranzusch PJ. Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep. 2021 06 01; 35(9):109206. PMID: 34077735.
    Citations: 1     Fields:    Translation:Cells
  7. Zhou W, Mohr L, Maciejowski J, Kranzusch PJ. cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol Cell. 2021 02 18; 81(4):739-755.e7. PMID: 33606975.
    Citations: 18     Fields:    Translation:HumansCells
  8. Eaglesham JB, McCarty KL, Kranzusch PJ. Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife. 2020 11 16; 9. PMID: 33191912.
    Citations: 9     Fields:    Translation:AnimalsCells
  9. Lowey B, Kranzusch PJ. CD-NTases and nucleotide second messenger signaling. Curr Biol. 2020 10 05; 30(19):R1106-R1108. PMID: 33022246.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ. STING cyclic dinucleotide sensing originated in bacteria. Nature. 2020 10; 586(7829):429-433. PMID: 32877915.
    Citations: 37     Fields:    Translation:AnimalsCells
  11. Lin B, Berard R, Al Rasheed A, Aladba B, Kranzusch PJ, Henderlight M, Grom A, Kahle D, Torreggiani S, Aue AG, Mitchell J, de Jesus AA, Schulert GS, Goldbach-Mansky R. A novel STING1 variant causes a recessive form of STING-associated vasculopathy with onset in infancy (SAVI). J Allergy Clin Immunol. 2020 11; 146(5):1204-1208.e6. PMID: 32673614.
    Citations: 11     Fields:    Translation:Humans
  12. Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 2020 07 09; 182(1):38-49.e17. PMID: 32544385.
    Citations: 18     Fields:    Translation:Cells
  13. Eaglesham JB, Kranzusch PJ. Conserved strategies for pathogen evasion of cGAS-STING immunity. Curr Opin Immunol. 2020 10; 66:27-34. PMID: 32339908.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  14. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 2020 02 20; 77(4):723-733.e6. PMID: 31932164.
    Citations: 33     Fields:    Translation:Cells
  15. Kranzusch PJ. cGAS and CD-NTase enzymes: structure, mechanism, and evolution. Curr Opin Struct Biol. 2019 12; 59:178-187. PMID: 31593902.
    Citations: 14     Fields:    Translation:HumansCells
  16. Zhou W, Whiteley AT, Kranzusch PJ. Analysis of human cGAS activity and structure. Methods Enzymol. 2019; 625:13-40. PMID: 31455523.
    Citations: 2     Fields:    Translation:HumansCells
  17. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 May; 569(7758):E12. PMID: 31081500.
    Citations: 1     Fields:    
  18. de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-?B Signaling Adaptation. Cell Rep. 2019 04 23; 27(4):1165-1175.e5. PMID: 31018131.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Hallberg ZF, Chan CH, Wright TA, Kranzusch PJ, Doxzen KW, Park JJ, Bond DR, Hammond MC. Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration. Elife. 2019 04 09; 8. PMID: 30964001.
    Citations: 11     Fields:    Translation:Cells
  20. Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. 2019 03 07; 176(6):1432-1446.e11. PMID: 30827685.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  21. Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 2019 03; 567(7747):194-199. PMID: 30787435.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  22. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 02; 566(7743):259-263. PMID: 30728498.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  23. Carey CM, Govande AA, Cooper JM, Hartley MK, Kranzusch PJ, Elde NC. Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates. Cell Host Microbe. 2019 02 13; 25(2):336-343.e4. PMID: 30713099.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  24. Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 2018 07 12; 174(2):300-311.e11. PMID: 30007416.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  25. de Oliveira Mann CC, Kranzusch PJ. cGAS Conducts Micronuclei DNA Surveillance. Trends Cell Biol. 2017 10; 27(10):697-698. PMID: 28882413.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. Brejc K, Bian Q, Uzawa S, Wheeler BS, Anderson EC, King DS, Kranzusch PJ, Preston CG, Meyer BJ. Dynamic Control of X Chromosome Conformation and Repression by a Histone H4K20 Demethylase. Cell. 2017 Sep 21; 171(1):85-102.e23. PMID: 28867287.
    Citations: 27     Fields:    Translation:AnimalsCells
  27. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. 2017 Sep 07; 170(6):1224-1233.e15. PMID: 28844692.
    Citations: 83     Fields:    Translation:HumansCells
  28. Lee AS, Kranzusch PJ, Doudna JA, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 2016 08 04; 536(7614):96-9. PMID: 27462815.
    Citations: 117     Fields:    Translation:HumansCells
  29. Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA. A bacterial Argonaute with noncanonical guide RNA specificity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4057-62. PMID: 27035975.
    Citations: 38     Fields:    Translation:Cells
  30. Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 2015 Nov 26; 527(7579):535-8. PMID: 26503043.
    Citations: 84     Fields:    Translation:Cells
  31. Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol Cell. 2015 Sep 17; 59(6):891-903. PMID: 26300263.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  32. Lee AS, Kranzusch PJ, Cate JH. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature. 2015 Jun 04; 522(7554):111-4. PMID: 25849773.
    Citations: 152     Fields:    Translation:HumansCells
  33. Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA. Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. 2014 Aug 28; 158(5):1011-1021. PMID: 25131990.
    Citations: 48     Fields:    Translation:HumansCells
  34. Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat Struct Mol Biol. 2014 Jun; 21(6):528-34. PMID: 24793649.
    Citations: 189     Fields:    Translation:Cells
  35. Liu W, Li Y, Shaw KS, Learn GH, Plenderleith LJ, Malenke JA, Sundararaman SA, Ramirez MA, Crystal PA, Smith AG, Bibollet-Ruche F, Ayouba A, Locatelli S, Esteban A, Mouacha F, Guichet E, Butel C, Ahuka-Mundeke S, Inogwabini BI, Ndjango JB, Speede S, Sanz CM, Morgan DB, Gonder MK, Kranzusch PJ, Walsh PD, Georgiev AV, Muller MN, Piel AK, Stewart FA, Wilson ML, Pusey AE, Cui L, Wang Z, Färnert A, Sutherland CJ, Nolder D, Hart JA, Hart TB, Bertolani P, Gillis A, LeBreton M, Tafon B, Kiyang J, Djoko CF, Schneider BS, Wolfe ND, Mpoudi-Ngole E, Delaporte E, Carter R, Culleton RL, Shaw GM, Rayner JC, Peeters M, Hahn BH, Sharp PM. African origin of the malaria parasite Plasmodium vivax. Nat Commun. 2014; 5:3346. PMID: 24557500.
    Citations: 94     Fields:    Translation:Animals
  36. Kranzusch PJ, Vance RE. cGAS dimerization entangles DNA recognition. Immunity. 2013 Dec 12; 39(6):992-4. PMID: 24332024.
    Citations: 9     Fields:    Translation:HumansAnimals
  37. Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 2013 May 30; 3(5):1362-8. PMID: 23707061.
    Citations: 140     Fields:    Translation:HumansCells
  38. Morin B, Kranzusch PJ, Rahmeh AA, Whelan SP. The polymerase of negative-stranded RNA viruses. Curr Opin Virol. 2013 Apr; 3(2):103-10. PMID: 23602472.
    Citations: 43     Fields:    Translation:Cells
  39. Kranzusch PJ, Whelan SP. Architecture and regulation of negative-strand viral enzymatic machinery. RNA Biol. 2012 Jul; 9(7):941-8. PMID: 22767259.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  40. Kranzusch PJ, Whelan SP. Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19743-8. PMID: 22106304.
    Citations: 48     Fields:    Translation:AnimalsCells
  41. Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011 Aug 24; 477(7364):340-3. PMID: 21866103.
    Citations: 619     Fields:    Translation:HumansAnimalsCells
  42. Radoshitzky SR, Warfield KL, Chi X, Dong L, Kota K, Bradfute SB, Gearhart JD, Retterer C, Kranzusch PJ, Misasi JN, Hogenbirk MA, Wahl-Jensen V, Volchkov VE, Cunningham JM, Jahrling PB, Aman MJ, Bavari S, Farzan M, Kuhn JH. Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry. J Virol. 2011 Sep; 85(17):8502-13. PMID: 21697477.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  43. Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP. Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20075-80. PMID: 21041632.
    Citations: 58     Fields:    Translation:Cells
  44. Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP. Assembly of a functional Machupo virus polymerase complex. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):20069-74. PMID: 20978208.
    Citations: 43     Fields:    Translation:Cells
  45. Liu W, Li Y, Learn GH, Rudicell RS, Robertson JD, Keele BF, Ndjango JB, Sanz CM, Morgan DB, Locatelli S, Gonder MK, Kranzusch PJ, Walsh PD, Delaporte E, Mpoudi-Ngole E, Georgiev AV, Muller MN, Shaw GM, Peeters M, Sharp PM, Rayner JC, Hahn BH. Origin of the human malaria parasite Plasmodium falciparum in gorillas. Nature. 2010 Sep 23; 467(7314):420-5. PMID: 20864995.
    Citations: 223     Fields:    Translation:HumansAnimals
  46. Radoshitzky SR, Dong L, Chi X, Clester JC, Retterer C, Spurgers K, Kuhn JH, Sandwick S, Ruthel G, Kota K, Boltz D, Warren T, Kranzusch PJ, Whelan SP, Bavari S. Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. J Virol. 2010 Oct; 84(20):10569-80. PMID: 20686043.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  47. Neel C, Etienne L, Li Y, Takehisa J, Rudicell RS, Bass IN, Moudindo J, Mebenga A, Esteban A, Van Heuverswyn F, Liegeois F, Kranzusch PJ, Walsh PD, Sanz CM, Morgan DB, Ndjango JB, Plantier JC, Locatelli S, Gonder MK, Leendertz FH, Boesch C, Todd A, Delaporte E, Mpoudi-Ngole E, Hahn BH, Peeters M. Molecular epidemiology of simian immunodeficiency virus infection in wild-living gorillas. J Virol. 2010 Feb; 84(3):1464-76. PMID: 19906908.
    Citations: 43     Fields:    Translation:AnimalsCells
  48. Rahmeh AA, Li J, Kranzusch PJ, Whelan SP. Ribose 2'-O methylation of the vesicular stomatitis virus mRNA cap precedes and facilitates subsequent guanine-N-7 methylation by the large polymerase protein. J Virol. 2009 Nov; 83(21):11043-50. PMID: 19710136.
    Citations: 56     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.