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Hooman Mirzakhani, Ph.D., M.D.


MGH Departmental Award-Clinical Research Day
2015 - 2017
Scholar Award-American Federation for Medical Research
Vitamin D Workshop Travel Award
Junior Investigator Award-IAMA
Clinical Science Award-American Lung Association
Scholarship Award-American Thoracic Society
Doctoral Dissertation Fellowship Award
2018 - 2020
NIH LRP-NHLBI Award (Renewal)
2020 - 2022
NIH LRP-NHLBI Award (Renewal)
Department of Medicine's Research Performance Incentive Program Award

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01HL146977 (MIRZAKHANI, HOOMAN) Jan 3, 2020 - Dec 31, 2024
    Integrative Longitudinal Genomics of Maternal Asthma-Preeclampsia Overlap and Risk of Childhood Asthma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chen YS, Lee-Sarwar KA, Mirzakhani H, O'Connor GT, Bacharier LB, Zeiger RS, Knihtilä HM, Jha A, Kelly RS, Laranjo N, Fichorova RN, Luu N, Weiss ST, Litonjua AA. The association of prenatal C-reactive protein levels with childhood asthma and atopy. J Allergy Clin Immunol Pract. 2022 Sep 12. PMID: 36108928.
  2. Li N, Mirzakhani H, Kiefer A, Koelle J, Vuorinen T, Rauh M, Yang Z, Krammer S, Xepapadaki P, Lewandowska-Polak A, Lukkarinen H, Zhang N, Stanic B, Zimmermann T, Kowalski ML, Jartti T, Bachert C, Akdis M, Papadopoulos NG, Raby BA, Weiss ST, Finotto S. Regulated on Activation, NormalT cell Expressed and Secreted (RANTES) drives the resolution of allergic asthma. iScience. 2021 Oct 22; 24(10):103163. PMID: 34693221.
  3. Chen YS, Mirzakhani H, Lu M, Zeiger RS, O'Connor GT, Sandel MT, Bacharier LB, Beigelman A, Carey VJ, Harshfield BJ, Laranjo N, Litonjua AA, Weiss ST, Lee-Sarwar KA. The Association of Prenatal Vitamin D Sufficiency With Aeroallergen Sensitization and Allergic Rhinitis in Early Childhood. J Allergy Clin Immunol Pract. 2021 10; 9(10):3788-3796.e3. PMID: 34166843.
    Citations:    Fields:    Translation:Humans
  4. Li J, Tiwari A, Mirzakhani H, Wang AL, Kho AT, McGeachie MJ, Litonjua AA, Weiss ST, Tantisira KG. Circulating MicroRNA: Incident Asthma Prediction and Vitamin D Effect Modification. J Pers Med. 2021 Apr 16; 11(4). PMID: 33923455; PMCID: PMC8073146.
    Citations: 1     
  5. Brustad N, Greve JH, Mirzakhani H, Pedersen CT, Eliasen AU, Stokholm J, Lasky-Su J, Bønnelykke K, Litonjua AA, Weiss ST, Bisgaard H, Chawes BL. High-dose vitamin D during pregnancy and pathway gene polymorphisms in prevention of offspring persistent wheeze. Pediatr Allergy Immunol. 2021 05; 32(4):679-689. PMID: 33453076.
    Citations: 1     Fields:    Translation:Humans
  6. McElrath TF, Cantonwine DE, Gray KJ, Mirzakhani H, Doss RC, Khaja N, Khalid M, Page G, Brohman B, Zhang Z, Sarracino D, Rosenblatt KP. Late first trimester circulating microparticle proteins predict the risk of preeclampsia PMID: 33087742.
    Citations: 4     Fields:    Translation:HumansCells
  7. Jakobi M, Kiefer A, Mirzakhani H, Rauh M, Zimmermann T, Xepapadaki P, Stanic B, Akdis M, Papadopoulos NG, Raby BA, Weiss ST, Finotto S. Role of nuclear factor of activated T cells 2 (NFATc2) in allergic asthma. Immun Inflamm Dis. 2020 12; 8(4):704-712. PMID: 33079489.
    Citations: 2     Fields:    Translation:HumansCells
  8. Yadama AP, Maiorino E, Carey VJ, McElrath TF, Litonjua AA, Loscalzo J, Weiss ST, Mirzakhani H. Early-pregnancy transcriptome signatures of preeclampsia: from peripheral blood to placenta. Sci Rep. 2020 10 12; 10(1):17029. PMID: 33046794.
    Citations: 2     Fields:    Translation:HumansCells
  9. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, Wilson ML, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study. BJOG. 2021 01; 128(1):55-65. PMID: 32741103.
    Citations: 4     Fields:    Translation:Humans
  10. Mirzakhani H, Weiss ST. Fetal sex and risk of preeclampsia: Dose maternal race matter? J Matern Fetal Neonatal Med. 2022 Sep; 35(17):3379-3387. PMID: 32924669; PMCID: PMC7954987.
    Citations: 2     Fields:    Translation:Humans
  11. Lu M, Litonjua AA, O'Connor GT, Zeiger RS, Bacharier L, Schatz M, Carey VJ, Weiss ST, Mirzakhani H. Effect of early and late prenatal vitamin D and maternal asthma status on offspring asthma or recurrent wheeze. J Allergy Clin Immunol. 2021 04; 147(4):1234-1241.e3. PMID: 32822692; PMCID: PMC7892633.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  12. Zarei S, Costas Y, Orozco G, Zaydlin M, Mirtar A, Abouali M, Diaz-Marty C, Akhlaghipour G, Fernandez Altamirano P, Gonzalez Cardona AR, Reiley LE, Mirzakhani H. A Web-Based Pharmacogenomics Search Tool for Precision Medicine in Perioperative Care. J Pers Med. 2020 Jul 21; 10(3). PMID: 32708157.
    Citations: 1     
  13. Mirzakhani H, Kelly RS, Yadama AP, Chu SH, Lasky-Su JA, Litonjua AA, Weiss ST. Stability of developmental status and risk of impairment at 24 and 36 months in late preterm infants. Infant Behav Dev. 2020 08; 60:101462. PMID: 32599336.
    Citations:    Fields:    Translation:Humans
  14. He M, Mirzakhani H, Chen L, Wu R, Litonjua AA, Bacharier L, Weiss ST, Nelson DM. Vitamin D Sufficiency Has a Limited Effect on Placental Structure and Pathology: Placental Phenotypes in the VDAART Trial. Endocrinology. 2020 06 01; 161(6). PMID: 32270179; PMCID: PMC7528633.
    Citations:    Fields:    Translation:Humans
  15. Litonjua AA, Carey VJ, Laranjo N, Stubbs BJ, Mirzakhani H, O'Connor GT, Sandel M, Beigelman A, Bacharier LB, Zeiger RS, Schatz M, Hollis BW, Weiss ST. Six-Year Follow-up of a Trial of Antenatal Vitamin D for Asthma Reduction. N Engl J Med. 2020 02 06; 382(6):525-533. PMID: 32023372; PMCID: PMC7444088.
    Citations: 40     Fields:    Translation:Humans
  16. Yadama AP, Mirzakhani H, McElrath TF, Litonjua AA, Weiss ST. Transcriptome analysis of early pregnancy vitamin D status and spontaneous preterm birth. PLoS One. 2020; 15(1):e0227193. PMID: 31995561.
    Citations: 6     Fields:    Translation:HumansCells
  17. Mirzakhani H, McElrath TF, Weiss ST. Vital Considerations for Aspirin in Prevention of Preeclampsia, a Multifaceted Pregnancy Disorder. JAMA Pediatr. 2020 01 01; 174(1):95. PMID: 31682681.
    Citations: 1     Fields:    Translation:Humans
  18. Koch S, Knipfer L, Kölle J, Mirzakhani H, Graser A, Zimmermann T, Kiefer A, Melichar VO, Rascher W, Papadopoulos NG, Rieker RJ, Raby BA, Weiss ST, Wirtz S, Finotto S. Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves experimental asthma by inhibiting Innate Lymphoid Cells group 2 (ILC2). Sci Rep. 2019 10 30; 9(1):15695. PMID: 31666531.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  19. Yadama AP, Kelly RS, Lee-Sarwar K, Mirzakhani H, Chu SH, Kachroo P, Litonjua AA, Lasky-Su J, Weiss ST. Allergic disease and low ASQ communication score in children. Brain Behav Immun. 2020 01; 83:293-297. PMID: 31606476.
    Citations: 4     Fields:    Translation:Humans
  20. Mirzakhani H, Carey VJ, McElrath TF, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Maternal Asthma, Preeclampsia, and Risk for Childhood Asthma at Age Six. Am J Respir Crit Care Med. 2019 09 01; 200(5):638-642. PMID: 31059286; PMCID: PMC6727151.
    Citations: 3     Fields:    Translation:Humans
  21. Kachroo P, Kelly RS, Mirzakhani H, Lee-Sarwar K, Chawes BL, Blighe K, Davaasambuu G, Bisgaard H, Litonjua AA, Weiss ST, Lasky-Su J. Fish oil supplementation during pregnancy is protective against asthma/wheeze in offspring. J Allergy Clin Immunol Pract. 2020 01; 8(1):388-391.e2. PMID: 31226448.
    Citations: 1     Fields:    Translation:Humans
  22. Nozari A, Akeju O, Mirzakhani H, Eskandar E, Ma Z, Hossain MA, Wang Q, Greenblatt DJ, Martyn JAJ. Prolonged therapy with the anticonvulsant carbamazepine leads to increased plasma clearance of fentanyl. J Pharm Pharmacol. 2019 Jun; 71(6):982-987. PMID: 30793320.
    Citations: 2     Fields:    Translation:Humans
  23. Mirzakhani H, Carey VJ, Zeiger R, Bacharier LB, O'Connor GT, Schatz MX, Laranjo N, Weiss ST, Litonjua AA. Impact of parental asthma, prenatal maternal asthma control, and vitamin D status on risk of asthma and recurrent wheeze in 3-year-old children. Clin Exp Allergy. 2019 04; 49(4):419-429. PMID: 30461089; PMCID: PMC6438751.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  24. Mirzakhani H, Carey VJ, McElrath TF, Qiu W, Hollis BW, O'Connor GT, Zeiger RS, Bacharier L, Litonjua AA, Weiss ST. Impact of Preeclampsia on the Relationship between Maternal Asthma and Offspring Asthma. An Observation from the VDAART Clinical Trial. Am J Respir Crit Care Med. 2019 01 01; 199(1):32-42. PMID: 30153046; PMCID: PMC6353019.
    Citations: 6     Fields:    Translation:Humans
  25. Mirzakhani, H, Weiss, ST. Folic Acid and Preeclampsia: Is There an Invisible Accomplice? The BMJ, December. 2018. View Publication.
  26. Mirzakhani, H,Weiss, ST . Mendelian Randomization of Vitamin D for Preeclampsia: Embracing Complexity of Inference. The BMJ, September. 2018. View Publication.
  27. Mirzakhani H, Al-Garawi AA, Carey VJ, Qiu W, Litonjua AA, Weiss ST. Expression network analysis reveals cord blood vitamin D-associated genes affecting risk of early life wheeze. Thorax. 2019 02; 74(2):200-202. PMID: 30021811.
    Citations: 1     Fields:    Translation:Humans
  28. Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension. 2018 08; 72(2):408-416. PMID: 29967039.
    Citations: 20     Fields:    Translation:Humans
  29. Mirzakhani H, Weiss ST, Litonjua AA. Reply. J Allergy Clin Immunol. 2018 02; 141(2):829-830. PMID: 29169707.
    Citations:    Fields:    Translation:Humans
  30. Mirzakhani H, De Vivo I, Leeder JS, Gaedigk R, Vyhlidal CA, Weiss ST, Tantisira K. Early pregnancy intrauterine fetal exposure to maternal smoking and impact on fetal telomere length. Eur J Obstet Gynecol Reprod Biol. 2017 Nov; 218:27-32. PMID: 28926727.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  31. Mirzakhani H, Carey VJ, McElrath TF, Laranjo N, O'Connor G, Iverson RE, Lee-Parritz A, Strunk RC, Bacharier LB, Macones GA, Zeiger RS, Schatz M, Hollis BW, Litonjua AA, Weiss ST. The Association of Maternal Asthma and Early Pregnancy Vitamin D with Risk of Preeclampsia: An Observation From Vitamin D Antenatal Asthma Reduction Trial (VDAART). J Allergy Clin Immunol Pract. 2018 Mar - Apr; 6(2):600-608.e2. PMID: 28923490.
    Citations: 9     Fields:    Translation:Humans
  32. Blighe K, Chawes BL, Kelly RS, Mirzakhani H, McGeachie M, Litonjua AA, Weiss ST, Lasky-Su JA. Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y. Am J Clin Nutr. 2017 Oct; 106(4):1092-1099. PMID: 28835366; PMCID: PMC5611786.
    Citations: 19     Fields:    Translation:Humans
  33. Kelly RS, Giorgio RT, Chawes BL, Palacios NI, Gray KJ, Mirzakhani H, Wu A, Blighe K, Weiss ST, Lasky-Su J. Applications of Metabolomics in the Study and Management of Preeclampsia; A Review of the Literature. Metabolomics. 2017 07; 13(7). PMID: 30473646.
    Citations: 12     Fields:    
  34. Mirzakhani H, O'Connor G, Bacharier LB, Zeiger RS, Schatz MX, Weiss ST, Litonjua AA. Asthma control status in pregnancy, body mass index, and maternal vitamin D levels. J Allergy Clin Immunol. 2017 11; 140(5):1453-1456.e7. PMID: 28606587; PMCID: PMC5708874.
    Citations: 10     Fields:    Translation:Humans
  35. Mirzakhani H, Eikermann M, Bittner E, Nozari A. In Response. Anesth Analg. 2017 04; 124(4):1371-1372. PMID: 28319553.
    Citations:    Fields:    
  36. Mirzakhani H, Eikermann M, Bittner E, Nozari A. In Response: Effective Doses of Neuromuscular Blockers During Electroconvulsive Therapy and the Effect of ECT Parameters. Anesth Analg. 2017 Feb 16. PMID: 28212216.
    Citations:    Fields:    
  37. Kelly RS, Croteau-Chonka DC, Dahlin A, Mirzakhani H, Wu AC, Wan ES, McGeachie MJ, Qiu W, Sordillo JE, Al-Garawi A, Gray KJ, McElrath TF, Carey VJ, Clish CB, Litonjua AA, Weiss ST, Lasky-Su JA. Integration of metabolomic and transcriptomic networks in pregnant women reveals biological pathways and predictive signatures associated with preeclampsia. Metabolomics. 2017 Jan; 13(1). PMID: 28596717; PMCID: PMC5458629.
    Citations: 24     Fields:    
  38. Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016 12 01; 126(12):4702-4715. PMID: 27841759; PMCID: PMC5127689.
    Citations: 49     Fields:    Translation:Humans
  39. Mirzakhani H, Nozari A. In Response. Anesth Analg. 2016 11; 123(5):1329-1330. PMID: 27551738.
    Citations:    Fields:    
  40. Al-Garawi A, Carey VJ, Chhabra D, Mirzakhani H, Morrow J, Lasky-Su J, Qiu W, Laranjo N, Litonjua AA, Weiss ST. The Role of Vitamin D in the Transcriptional Program of Human Pregnancy. PLoS One. 2016; 11(10):e0163832. PMID: 27711190.
    Citations: 14     Fields:    Translation:HumansCells
  41. Mirzakhani H, Bittner E, Eikermann M, Nozari A. In Response. Anesth Analg. 2016 10; 123(4):1060-1. PMID: 27636580.
    Citations:    Fields:    
  42. Sigakis MJ, Leffert LR, Mirzakhani H, Sharawi N, Rajala B, Callaghan WM, Kuklina EV, Creanga AA, Mhyre JM, Bateman BT. The Validity of Discharge Billing Codes Reflecting Severe Maternal Morbidity. Anesth Analg. 2016 09; 123(3):731-8. PMID: 27387839; PMCID: PMC7481827.
    Citations: 9     Fields:    Translation:Humans
  43. Mirzakhani H, Guchelaar HJ, Welch CA, Cusin C, Doran ME, MacDonald TO, Bittner EA, Eikermann M, Nozari A. Minimum Effective Doses of Succinylcholine and Rocuronium During Electroconvulsive Therapy: A Prospective, Randomized, Crossover Trial. Anesth Analg. 2016 09; 123(3):587-96. PMID: 26967896.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  44. Koch S, Graser A, Mirzakhani H, Zimmermann T, Melichar VO, Wölfel M, Croteau-Chonka DC, Raby BA, Weiss ST, Finotto S. Increased expression of nuclear factor of activated T cells 1 drives IL-9-mediated allergic asthma. J Allergy Clin Immunol. 2016 06; 137(6):1898-1902.e7. PMID: 26993036; PMCID: PMC4889777.
    Citations: 7     Fields:    Translation:Humans
  45. Mirzakhani, H. The Role of Clinical Pharmacology and Pharmacogenetics in Electroconvulsive Therapy: From Safety to Efficacy (Doctoral Dissertation). Leiden University Medical Center, Leiden University, The Netherlands (ISBN 9789492026088). 2016. View Publication.
  46. Mirzakhani H, van Dormolen J, van der Weide K, Guchelaar HJ, van Noorden MS, Swen J. Aberrant CYP2D6 metabolizer phenotypes do not show increased frequency in patients undergoing ECT after antidepressant therapy. Pharmacogenet Genomics. 2015 Oct; 25(10):515-7. PMID: 26230381.
    Citations:    Fields:    Translation:Humans
  47. Mirzakhani H, van Noorden MS, Swen J, Nozari A, Guchelaar HJ. Pharmacogenetics in electroconvulsive therapy and adjunctive medications. Pharmacogenomics. 2015; 16(9):1015-31. PMID: 26115083.
    Citations:    Fields:    Translation:Humans
  48. Mirzakhani, H . Impact of Vitamin D and Asthma on Preeclampsia: A Sequential Evidence-Based Approach to Genomic Analysis (Master's Thesis). Harvard Medical School, Boston, MA, USA. 2015.
  49. Mirzakhani H, Al-Garawi A, Weiss ST, Litonjua AA. Vitamin D and the development of allergic disease: how important is it? Clin Exp Allergy. 2015 Jan; 45(1):114-25. PMID: 25307157.
    Citations: 41     Fields:    Translation:Humans
  50. Kamran Hejazi Kenari S, Mirzakhani H, Eslami M, Saidi RF. Current state of the art in management of vascular complications after pediatric liver transplantation. Pediatr Transplant. 2015 Feb; 19(1):18-26. PMID: 25425338.
    Citations: 3     Fields:    Translation:Humans
  51. Kamran Hejazi Kenari S, Mirzakhani H, Saidi RF. Pediatric transplantation and tolerance: past, present, and future. Pediatr Transplant. 2014 Aug; 18(5):435-45. PMID: 24931282.
    Citations: 3     Fields:    Translation:HumansCells
  52. Mirzakhani H, Williams JN, Mello J, Joseph S, Meyer MJ, Waak K, Schmidt U, Kelly E, Eikermann M. Muscle weakness predicts pharyngeal dysfunction and symptomatic aspiration in long-term ventilated patients. Anesthesiology. 2013 Aug; 119(2):389-97. PMID: 23584384.
    Citations: 27     Fields:    Translation:Humans
  53. Mirzakhani H, Nozari A, Ehrenfeld JM, Peterfreund R, Szabo M, Walsh JL, Jiang Y, Sandberg W, Rosow C, Wang J. Case report: profound hypotension after anesthetic induction with propofol in patients treated with rifampin. Anesth Analg. 2013 Jul; 117(1):61-4. PMID: 23687230.
    Citations: 1     Fields:    Translation:Humans
  54. Mirzakhani H, Eikermann M. Train-of-four recovery does not indicate optimal recovery of the margin of safety of neuromuscular transmission. Eur J Anaesthesiol. 2013 Jan; 30(1):40-1. PMID: 22801583.
    Citations:    Fields:    Translation:Humans
  55. Edward Bittner, Arielle Butterly, Hooman Mirzakhani, Abhishek Jayadevappa, Theresa MacDonald, Edward George, Ulrich Schmidt, Matthias Eikermann . Severe postoperative hemodynamic events after spinal anesthesia a prospective observational study. Journal of Anesthesiology & Clinical Science. 2012; 14(1):1-8. View Publication.
  56. Mirzakhani H, Welch CA, Eikermann M, Nozari A. Neuromuscular blocking agents for electroconvulsive therapy: a systematic review. Acta Anaesthesiol Scand. 2012 Jan; 56(1):3-16. PMID: 22092267.
    Citations: 13     Fields:    Translation:Humans
  57. Mirzakhani, H. and Nozari. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood. Ischemia. 2011; Ch10:145-58. View Publication.
  58. Mirzakhani, H. Computer in Plastic Surgery (Doctoral Dissertation). Tehran University of Medical Sciences, Tehran, Iran. 1997.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.