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Shoelson, Steven
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Steven E. Shoelson, M.D., Ph.D.
Title
Professor of Medicine
Institution
Joslin Diabetes Center
Department
Medicine
Address
Joslin Diabetes Center
Research Division
One Joslin Place
Boston MA 02215
Phone
617/732-2528
Fax
617/732-2407
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01DK112153
(SHOELSON, STEVEN E)
May 2, 2018 - Mar 31, 2022
NIH
Feeding Drives HSF1 Transcriptional Programs Required for Global Protein Synthesis
Role: Principal Investigator
R01HL133329
(SHOELSON, STEVEN E)
May 20, 2016 - Mar 31, 2020
NIH
Intrinsic anti-inflammatory actions of AMPK activation rendered through a novel immunometabolic AMPK-mTOR-NFkB Pathway
Role: Principal Investigator
R01DK108936
(SHOELSON, STEVEN E)
May 16, 2016 - Mar 31, 2020
NIH
Xanthine oxidase inhibition raises intracellular purines to activate AMPK, improve glucose control and decrease fatty liver and atherosclerosis in type 2 diabetes
Role: Principal Investigator
R01DK095327
(SHOELSON, STEVEN E)
Apr 1, 2014 - Mar 31, 2018
NIH
Targeting Neutrophils and Leukotrienes to Treat Type 2 Diabetes
Role: Principal Investigator
RC4DK090792
(SHOELSON, STEVEN E)
Sep 30, 2010 - Sep 29, 2012
NIH
Mechanism-Based Biomarkers for Glucose-Lowering in TINSAL-T2D
Role: Principal Investigator
U01DK074556
(SHOELSON, STEVEN E)
Sep 4, 2006 - Jun 30, 2013
NIH
Targeting Inflammation in Type 2 Diabetes: Clinical Trial Using Salsalate
Role: Principal Investigator
P50HL083813
(WELTY, FRANCINE K)
May 1, 2006 - May 31, 2015
NIH
Metabolic Syndrome, Inflammation and Vascular Remodeling
Role: Co-Principal Investigator
R01DK073547
(SHOELSON, STEVEN E)
Feb 15, 2006 - Jun 30, 2011
NIH
TOLL RECEPTOR ACTIVATION OF NF-kB IN INSULIN RESISTANCE AND T2DM
Role: Principal Investigator
R37DK051729
(SHOELSON, STEVEN E)
Sep 21, 1996 - Jun 30, 2011
NIH
Mediators and Modifiers of NF-kappaB in Insulin Resistance
Role: Principal Investigator
R01DK051729
(SHOELSON, STEVEN E)
Sep 21, 1996 - Aug 31, 2005
NIH
IKK MEDIATED INSULIN RESISTANCE AND IN VIVO REVERSAL
Role: Principal Investigator
R01DK045943
(SHOELSON, STEVEN E)
Aug 1, 1996 - Dec 31, 2010
NIH
EFFECTS OF IKKB and NFkB IN INSULIN RESISTANCE
Role: Principal Investigator
R01DK043123
(SHOELSON, STEVEN E)
Sep 30, 1992 - Dec 31, 2009
NIH
Ser/Thr Phosphorylation in Insulin Resistance
Role: Principal Investigator
P30DK036836
(KING, GEORGE L)
Sep 30, 1986 - Mar 31, 2022
NIH
Diabetes Research Center
Role: Co-Principal Investigator
M01RR002635
(GOTTLIEB, GARY L)
Dec 1, 1984 - Mar 31, 2010
NIH
General Clinical Research Center
Role: Co-Principal Investigator
M01RR001032
(SUKHATME, VIKAS P)
Dec 1, 1977 - Mar 31, 2010
NIH
General Clinical Research Center
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Kim OH, Kang GH, Hur J, Lee J, Jung Y, Hong IS, Lee H, Seo SY, Lee DH, Lee CS, Lee IK,
Bonner-Weir S
, Lee J, Park YJ, Kim H,
Shoelson SE
, Oh BC. Externalized phosphatidylinositides on apoptotic cells are eat-me signals recognized by CD14. Cell Death Differ. 2022 07; 29(7):1423-1432.
PMID:
35017647
; PMCID:
PMC9287416
.
Citations:
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Valentine JM, Li ME,
Shoelson SE
, Zhang N, Reddick RL, Musi N. NF?B Regulates Muscle Development and Mitochondrial Function. J Gerontol A Biol Sci Med Sci. 2020 03 09; 75(4):647-653.
PMID:
30423026
; PMCID:
PMC7328192
.
Citations:
5
Fields:
Ger
Geriatrics
Translation:
Animals
Cells
Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K,
Shoelson SE
, Yamamoto H, Higashida H. Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Commun Biol. 2019; 2:76.
PMID:
30820471
.
Citations:
44
Translation:
Humans
Animals
Cells
Salastekar N, Desai T,
Hauser T
, Schaefer EJ, Fowler K, Joseph S,
Shoelson SE
, Goldfine AB. Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin-treated cardiovascular disease: A 30-month randomized placebo-controlled trial. Diabetes Obes Metab. 2017 10; 19(10):1458-1462.
PMID:
28295931
.
Citations:
7
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M,
Shoelson SE
, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N. Sustained NF?B inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell. 2017 08; 16(4):847-858.
PMID:
28556540
; PMCID:
PMC5506420
.
Citations:
12
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Woo JR, Kim SJ, Kim KY, Jang H,
Shoelson SE
, Park S. The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization. Int J Biol Macromol. 2017 Oct; 103:965-971.
PMID:
28545963
; PMCID:
PMC5548637
.
Citations:
3
Fields:
Bio
Biochemistry
Mol
Molecular Biology
Translation:
Humans
Cells
Goldfine AB,
Shoelson SE
. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest. 2017 01 03; 127(1):83-93.
PMID:
28045401
; PMCID:
PMC5199685
.
Citations:
54
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Oh J
,
Sinha I
, Tan KY,
Rosner B
,
Dreyfuss JM
, Gjata O, Tran P,
Shoelson SE
,
Wagers AJ
. Age-associated NF-?B signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 11 14; 8(11):2871-2896.
PMID:
27852976
.
Citations:
26
Fields:
Ger
Geriatrics
Translation:
Humans
Animals
Cells
Hauser TH
, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM,
Weber GM
,
Welty F
,
Clouse M
,
Shoelson SE
, Goldfine AB. Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. JAMA Cardiol. 2016 07 01; 1(4):413-23.
PMID:
27438317
.
Citations:
20
Fields:
Car
Cardiology
Translation:
Humans
Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ,
Shoelson SE
, Lee J. Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metab. 2016 Apr 12; 23(4):685-98.
PMID:
27050305
; PMCID:
PMC4833527
.
Citations:
111
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Animals
Cells
Rubin MR, Goldfine AB, McMahon DJ, Donovan DS, Cremers S, Dworakowski E, Schaefer EJ,
Shoelson SE
, Silverberg SJ. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus. Endocrine. 2015 Nov; 50(2):504-7.
PMID:
25636441
.
Citations:
3
Fields:
End
Endocrinology
Translation:
Humans
Okazaki T,
Liang F
, Li T, Lemaire C, Danialou G,
Shoelson SE
, Petrof BJ. Muscle-specific inhibition of the classical nuclear factor-?B pathway is protective against diaphragmatic weakness in murine endotoxemia. Crit Care Med. 2014 Jul; 42(7):e501-9.
PMID:
24933061
.
Citations:
9
Fields:
Cri
Critical Care
Translation:
Animals
Cells
Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S,
Shoelson S
, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Functional characterization of obesity-associated variants involving the a and ß isoforms of human SH2B1. Endocrinology. 2014 Sep; 155(9):3219-26.
PMID:
24971614
; PMCID:
PMC4138566
.
Citations:
16
Fields:
End
Endocrinology
Translation:
Humans
Cells
Lee J, Miyazaki M,
Romeo GR
,
Shoelson SE
. Insulin receptor activation with transmembrane domain ligands. J Biol Chem. 2014 Jul 11; 289(28):19769-77.
PMID:
24867955
.
Citations:
18
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Goldfine AB, Jablonski KA,
Shoelson SE
, Creager MA. Response to comment on Goldfine et al. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes care 2013;36:4132-4139. Diabetes Care. 2014 May; 37(5):e112.
PMID:
24757239
.
Citations:
Fields:
End
Endocrinology
Translation:
Humans
Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR,
Shoelson SE
, Lee J. Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone. PLoS One. 2013; 8(12):e82847.
PMID:
24376593
.
Citations:
14
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Barzilay JI, Jablonski KA, Fonseca V,
Shoelson SE
, Goldfine AB, Strauch C, Monnier VM. The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. Diabetes Care. 2014 Apr; 37(4):1083-91.
PMID:
24255104
.
Citations:
11
Fields:
End
Endocrinology
Translation:
Humans
CT
Clinical Trials
King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA,
Bonner-Weir S
,
Shoelson SE
,
Weir GC
. Sustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes. PLoS One. 2013; 8(10):e77452.
PMID:
24204831
.
Citations:
3
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Goldfine AB, Buck JS, Desouza C, Fonseca V, Chen YD,
Shoelson SE
, Jablonski KA, Creager MA. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes Care. 2013 Dec; 36(12):4132-9.
PMID:
24130358
.
Citations:
18
Fields:
End
Endocrinology
Translation:
Humans
Romeo GR
, Pae M, Eberlé D, Lee J,
Shoelson SE
. Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes. 2013 Nov; 62(11):3718-26.
PMID:
23884883
; PMCID:
PMC3806603
.
Citations:
14
Fields:
End
Endocrinology
Translation:
Animals
Cells
Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA,
Shoelson SE
. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2013 Jul 02; 159(1):1-12.
PMID:
23817699
; PMCID:
PMC4128629
.
Citations:
95
Fields:
Int
Internal Medicine
Translation:
Humans
CT
Clinical Trials
Goldfine AB,
Conlin PR
, Halperin F, Koska J, Permana P, Schwenke D,
Shoelson SE
, Reaven PD. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia. 2013 Apr; 56(4):714-23.
PMID:
23370525
.
Citations:
52
Fields:
End
Endocrinology
Translation:
Humans
Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J,
Shoelson SE
, Jobin C,
Rask-Madsen C
,
King GL
. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32.
PMID:
23197686
.
Citations:
15
Fields:
Oph
Ophthalmology
Translation:
Animals
Romeo GR
, Lee J,
Shoelson SE
. Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1771-6.
PMID:
22815343
.
Citations:
148
Fields:
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Cipolletta D, Feuerer M, Li A, Kamei N, Lee J,
Shoelson SE
,
Benoist C
,
Mathis D
. PPAR-? is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012 Jun 28; 486(7404):549-53.
PMID:
22722857
.
Citations:
527
Fields:
Sci
Science
Translation:
Animals
Cells
Schakman O, Dehoux M, Bouchuari S, Delaere S, Lause P, Decroly N,
Shoelson SE
, Thissen JP. Role of IGF-I and the TNFa/NF-?B pathway in the induction of muscle atrogenes by acute inflammation. Am J Physiol Endocrinol Metab. 2012 Sep 15; 303(6):E729-39.
PMID:
22739109
.
Citations:
31
Fields:
End
Endocrinology
Met
Metabolism
Phy
Physiology
Translation:
Animals
Cells
Langen RC, Haegens A, Vernooy JH, Wouters EF, de Winther MP, Carlsen H, Steele C,
Shoelson SE
, Schols AM. NF-?B activation is required for the transition of pulmonary inflammation to muscle atrophy. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):288-97.
PMID:
22538866
.
Citations:
34
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Haegens A, Schols AM, Gorissen SH, van Essen AL, Snepvangers F, Gray DA,
Shoelson SE
, Langen RC. NF-?B activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L103-10.
PMID:
22003096
.
Citations:
24
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Phy
Physiology
Pul
Pulmonary Medicine
Translation:
Humans
Animals
Cells
van Diepen JA, Vroegrijk IO, Berbée JF,
Shoelson SE
, Romijn JA, Havekes LM, Rensen PC, Voshol PJ. Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2011 Dec; 301(6):E1099-107.
PMID:
21862721
.
Citations:
9
Fields:
End
Endocrinology
Met
Metabolism
Phy
Physiology
Translation:
Animals
Cells
Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ,
Shoelson SE
, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF. Hepatocyte-specific IKKß expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis. 2012 Feb; 220(2):362-8.
PMID:
21798539
.
Citations:
10
Fields:
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Park SY, Jin W, Woo JR,
Shoelson SE
. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J Biol Chem. 2011 May 20; 286(20):18130-8.
PMID:
21454505
.
Citations:
15
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
van Diepen JA, Wong MC, Guigas B, Bos J, Stienstra R, Hodson L,
Shoelson SE
, Berbée JF, Rensen PC, Romijn JA, Havekes LM, Voshol PJ. Hepatocyte-specific IKK-ß activation enhances VLDL-triglyceride production in APOE*3-Leiden mice. J Lipid Res. 2011 May; 52(5):942-50.
PMID:
21357939
.
Citations:
11
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Mathis D
,
Shoelson SE
. Immunometabolism: an emerging frontier. Nat Rev Immunol. 2011 Feb; 11(2):81.
PMID:
21469396
.
Citations:
199
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
Donath MY,
Shoelson SE
. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011 Feb; 11(2):98-107.
PMID:
21233852
.
Citations:
1142
Fields:
All
Allergy and Immunology
Translation:
Humans
Goldfine AB, Fonseca V,
Shoelson SE
. Therapeutic approaches to target inflammation in type 2 diabetes. Clin Chem. 2011 Feb; 57(2):162-7.
PMID:
21098138
.
Citations:
38
Fields:
Che
Chemistry
Translation:
Humans
Animals
Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA,
Shoelson SE
. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2010 Mar 16; 152(6):346-57.
PMID:
20231565
; PMCID:
PMC3138470
.
Citations:
169
Fields:
Int
Internal Medicine
Translation:
Humans
Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D,
Shoelson S
, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clément K, Guerre-Millo M. Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. J Clin Endocrinol Metab. 2010 Apr; 95(4):1861-8.
PMID:
20164293
.
Citations:
39
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Animals
Cells
Herrero L, Shapiro H, Nayer A, Lee J,
Shoelson SE
. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):240-5.
PMID:
20007767
.
Citations:
83
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Rha GB, Wu G,
Shoelson SE
, Chi YI. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation. J Biol Chem. 2009 Dec 11; 284(50):35165-76.
PMID:
19846556
.
Citations:
15
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB,
Benoist C
,
Shoelson S
,
Mathis D
. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug; 15(8):930-9.
PMID:
19633656
.
Citations:
918
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Animals
Cells
Goldfine AB,
Shoelson SE
, Aguirre V. Expansion and contraction: treating diabetes with bariatric surgery. Nat Med. 2009 Jun; 15(6):616-7.
PMID:
19498374
.
Citations:
17
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Shoelson SE
, Goldfine AB. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat Med. 2009 Apr; 15(4):373-4.
PMID:
19350009
.
Citations:
51
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D,
Shoelson SE
, Gozani O,
Kingston RE
,
Benoist C
,
Mathis D
. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83.
PMID:
18840680
; PMCID:
PMC2572939
.
Citations:
83
Fields:
Sci
Science
Translation:
Animals
Cells
Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J,
Shoelson SE
. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May; 1(1):36-43.
PMID:
19337387
.
Citations:
136
Fields:
Med
Medicine (General)
Translation:
Humans
CT
Clinical Trials
Park SY,
Shoelson SE
. When a domain is not a domain. Nat Struct Mol Biol. 2008 Mar; 15(3):224-6.
PMID:
18319738
.
Citations:
2
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Fleischman A
,
Shoelson SE
, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2008 Feb; 31(2):289-94.
PMID:
17959861
; PMCID:
PMC3226794
.
Citations:
140
Fields:
End
Endocrinology
Translation:
Humans
Abedini A,
Shoelson SE
. Inflammation and obesity: STAMPing out insulin resistance? Immunol Cell Biol. 2007 Aug-Sep; 85(6):399-400.
PMID:
17646847
.
Citations:
5
Fields:
All
Allergy and Immunology
Cel
Cell Biology
Translation:
Humans
Animals
Shoelson SE
, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology. 2007 May; 132(6):2169-80.
PMID:
17498510
.
Citations:
618
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Shoelson SE
. Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol (1985). 2007 02; 102(2):820; author reply 825.
PMID:
17323463
.
Citations:
2
Fields:
Phy
Physiology
Translation:
Humans
Animals
Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D,
Gervino EV
, Johnstone MT, Trischitta V,
Shoelson SE
,
Doria A
. Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes. 2007 Feb; 56(2):499-505.
PMID:
17259397
.
Citations:
37
Fields:
End
Endocrinology
Translation:
Humans
Shoelson SE
. Banking on ATM as a new target in metabolic syndrome. Cell Metab. 2006 Nov; 4(5):337-8.
PMID:
17084707
.
Citations:
13
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Animals
Cells
Shoelson SE
, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006 Jul; 116(7):1793-801.
PMID:
16823477
; PMCID:
PMC1483173
.
Citations:
1466
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Ho RC, Hirshman MF, Li Y, Cai D,
Farmer JR
, Aschenbach WG, Witczak CA,
Shoelson SE
,
Goodyear LJ
. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C794-801.
PMID:
15888549
.
Citations:
37
Fields:
Cel
Cell Biology
Phy
Physiology
Translation:
Animals
Cells
Nishi M, Werner ED, Oh BC, Frantz JD,
Dhe-Paganon S
, Hansen L, Lee J,
Shoelson SE
. Kinase activation through dimerization by human SH2-B. Mol Cell Biol. 2005 Apr; 25(7):2607-21.
PMID:
15767667
; PMCID:
PMC1061652
.
Citations:
29
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J,
Shoelson SE
. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005 Feb; 11(2):183-90.
PMID:
15685173
; PMCID:
PMC1440292
.
Citations:
797
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Cai D, Frantz JD,
Tawa NE
, Melendez PA, Oh BC,
Lidov HG
,
Hasselgren PO
, Frontera WR, Lee J,
Glass DJ
,
Shoelson SE
. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004 Oct 15; 119(2):285-98.
PMID:
15479644
.
Citations:
526
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Dhe-Paganon S
, Werner ED, Nishi M, Hansen L, Chi YI,
Shoelson SE
. A phenylalanine zipper mediates APS dimerization. Nat Struct Mol Biol. 2004 Oct; 11(10):968-74.
PMID:
15378031
.
Citations:
23
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Werner ED, Lee J, Hansen L, Yuan M,
Shoelson SE
. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J Biol Chem. 2004 Aug 20; 279(34):35298-305.
PMID:
15199052
.
Citations:
88
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Duda K, Chi YI,
Shoelson SE
. Structural basis for HNF-4alpha activation by ligand and coactivator binding. J Biol Chem. 2004 May 28; 279(22):23311-6.
PMID:
14982928
.
Citations:
28
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Shoelson SE
, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord. 2003 Dec; 27 Suppl 3:S49-52.
PMID:
14704745
.
Citations:
145
Fields:
Met
Metabolism
Nut
Nutritional Sciences
Translation:
Humans
Animals
Cai D,
Dhe-Paganon S
, Melendez PA, Lee J,
Shoelson SE
. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem. 2003 Jul 11; 278(28):25323-30.
PMID:
12730241
.
Citations:
65
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW,
Shoelson SE
, Lee MS. Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3. Diabetologia. 2003 May; 46(5):721-7.
PMID:
12712243
.
Citations:
10
Fields:
End
Endocrinology
Translation:
Humans
Cells
Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ,
Shoelson SE
, Liu F. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem. 2003 Mar 07; 278(10):8460-7.
PMID:
12493740
.
Citations:
37
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Chi YI, Frantz JD, Oh BC, Hansen L,
Dhe-Paganon S
,
Shoelson SE
. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Mol Cell. 2002 Nov; 10(5):1129-37.
PMID:
12453420
.
Citations:
45
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Rui L, Yuan M, Frantz D,
Shoelson S
,
White MF
. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem. 2002 Nov 01; 277(44):42394-8.
PMID:
12228220
.
Citations:
319
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Dhe-Paganon S
, Duda K, Iwamoto M, Chi YI,
Shoelson SE
. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J Biol Chem. 2002 Oct 11; 277(41):37973-6.
PMID:
12193589
.
Citations:
94
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S,
Shoelson SE
, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest. 2002 May; 109(10):1321-6.
PMID:
12021247
; PMCID:
PMC150979
.
Citations:
213
Fields:
Med
Medicine (General)
Translation:
Humans
Menzaghi C, Plengvidhya N, Ma X, Warram JH,
Shoelson SE
,
Doria A
. Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. J Clin Endocrinol Metab. 2002 Apr; 87(4):1894-7.
PMID:
11932336
.
Citations:
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Dhe-Paganon S
, Werner ED, Chi YI,
Shoelson SE
. Structure of the globular tail of nuclear lamin. J Biol Chem. 2002 May 17; 277(20):17381-4.
PMID:
11901143
.
Citations:
87
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Aguirre V, Werner ED, Giraud J, Lee YH,
Shoelson SE
,
White MF
. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002 Jan 11; 277(2):1531-7.
PMID:
11606564
.
Citations:
318
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M,
Shoelson SE
. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001 Aug 31; 293(5535):1673-7.
PMID:
11533494
.
Citations:
620
Fields:
Sci
Science
Translation:
Animals
Cells
Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P,
Shoelson SE
, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest. 2001 Aug; 108(3):437-46.
PMID:
11489937
; PMCID:
PMC209353
.
Citations:
210
Fields:
Med
Medicine (General)
Translation:
Animals
Cells
Lindholm CK, Frantz JD,
Shoelson SE
, Welsh M. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Biochem Biophys Res Commun. 2000 Nov 30; 278(3):537-43.
PMID:
11095946
.
Citations:
8
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Dhe-Paganon S
, Shigeta R, Chi YI, Ristow M,
Shoelson SE
. Crystal structure of human frataxin. J Biol Chem. 2000 Oct 06; 275(40):30753-6.
PMID:
10900192
.
Citations:
78
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
O'Reilly AM, Pluskey S,
Shoelson SE
, Neel BG. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol. 2000 Jan; 20(1):299-311.
PMID:
10594032
.
Citations:
38
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Dhe-Paganon S
, Ottinger EA, Nolte RT,
Eck MJ
,
Shoelson SE
. Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8378-83.
PMID:
10411883
; PMCID:
PMC17524
.
Citations:
24
Fields:
Sci
Science
Translation:
Humans
Cells
Rapoport I
, Chen YC, Cupers P,
Shoelson SE
,
Kirchhausen T
. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 1998 Apr 15; 17(8):2148-55.
PMID:
9545228
; PMCID:
PMC1170559
.
Citations:
82
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Animals
Cells
Bjørbaek C, Elmquist JK, Frantz JD,
Shoelson SE
,
Flier JS
. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998 Mar; 1(4):619-25.
PMID:
9660946
.
Citations:
260
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Hof P, Pluskey S,
Dhe-Paganon S
,
Eck MJ
,
Shoelson SE
. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 1998 Feb 20; 92(4):441-50.
PMID:
9491886
.
Citations:
264
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M,
Cantley LC
, Band H,
Shoelson SE
. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 1998 Feb 19; 16(7):891-901.
PMID:
9484780
.
Citations:
14
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Kay LE, Muhandiram DR, Wolf G,
Shoelson SE
, Forman-Kay JD. Correlation between binding and dynamics at SH2 domain interfaces. Nat Struct Biol. 1998 Feb; 5(2):156-63.
PMID:
9461082
.
Citations:
36
Fields:
Mol
Molecular Biology
Translation:
Cells
Ottinger EA, Botfield MC,
Shoelson SE
. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J Biol Chem. 1998 Jan 09; 273(2):729-35.
PMID:
9422724
.
Citations:
61
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Lupher ML, Songyang Z,
Shoelson SE
,
Cantley LC
, Band H. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem. 1997 Dec 26; 272(52):33140-4.
PMID:
9407100
.
Citations:
53
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Shoelson SE
. SH2 and PTB domain interactions in tyrosine kinase signal transduction. Curr Opin Chem Biol. 1997 Aug; 1(2):227-34.
PMID:
9667855
.
Citations:
14
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Rapoport I
, Miyazaki M, Boll W, Duckworth B,
Cantley LC
,
Shoelson S
,
Kirchhausen T
. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 01; 16(9):2240-50.
PMID:
9171339
; PMCID:
PMC1169826
.
Citations:
68
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Animals
Cells
Lee J, Pilch PF,
Shoelson SE
, Scarlata SF. Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry. 1997 Mar 04; 36(9):2701-8.
PMID:
9054578
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Giorgetti-Peraldi S, Ottinger E, Wolf G, Ye B, Burke TR,
Shoelson SE
. Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking. Mol Cell Biol. 1997 Mar; 17(3):1180-8.
PMID:
9032245
.
Citations:
3
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Frantz JD, Giorgetti-Peraldi S, Ottinger EA,
Shoelson SE
. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem. 1997 Jan 31; 272(5):2659-67.
PMID:
9006901
.
Citations:
25
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Trüb T, Frantz JD, Miyazaki M, Band H,
Shoelson SE
. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem. 1997 Jan 10; 272(2):894-902.
PMID:
8995379
.
Citations:
35
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Ricketts WA, Rose DW,
Shoelson S
, Olefsky JM. Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling. J Biol Chem. 1996 Oct 18; 271(42):26165-9.
PMID:
8824262
.
Citations:
4
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Sawasdikosol S, Chang JH, Pratt JC, Wolf G,
Shoelson SE
, Burakoff SJ. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J Immunol. 1996 Jul 01; 157(1):110-6.
PMID:
8683103
.
Citations:
8
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Eck MJ
,
Dhe-Paganon S
, Trüb T, Nolte RT,
Shoelson SE
. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell. 1996 May 31; 85(5):695-705.
PMID:
8646778
.
Citations:
72
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Ravichandran KS, Igras V,
Shoelson SE
, Fesik SW, Burakoff SJ. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5275-80.
PMID:
8643566
; PMCID:
PMC39235
.
Citations:
22
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Pratt JC, Weiss M,
Sieff CA
,
Shoelson SE
, Burakoff SJ, Ravichandran KS. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem. 1996 May 24; 271(21):12137-40.
PMID:
8647804
.
Citations:
14
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY,
Shoelson SE
, Druker BJ, Band H. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 05; 271(14):8435-42.
PMID:
8626543
.
Citations:
31
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trüb T,
Shoelson SE
, Fesik SW. Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat Struct Biol. 1996 Apr; 3(4):388-93.
PMID:
8599766
.
Citations:
35
Fields:
Mol
Molecular Biology
Translation:
Cells
Nolte RT,
Eck MJ
, Schlessinger J,
Shoelson SE
,
Harrison SC
. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nat Struct Biol. 1996 Apr; 3(4):364-74.
PMID:
8599763
.
Citations:
54
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Burke TR, Ye B, Akamatsu M, Ford H, Yan X, Kole HK, Wolf G,
Shoelson SE
, Roller PP. 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. J Med Chem. 1996 Mar 01; 39(5):1021-7.
PMID:
8676336
.
Citations:
4
Fields:
Che
Chemistry
Translation:
Humans
Animals
Cells
Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B,
Shoelson S
,
Cantley L
, Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1996 Feb 09; 271(6):3187-94.
PMID:
8621719
.
Citations:
26
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Eck MJ
, Pluskey S, Trüb T,
Harrison SC
,
Shoelson SE
. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature. 1996 Jan 18; 379(6562):277-80.
PMID:
8538796
.
Citations:
53
Fields:
Sci
Science
Translation:
Humans
Cells
Lee J,
Shoelson SE
, Pilch PF. Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity. J Biol Chem. 1995 Dec 29; 270(52):31136-40.
PMID:
8537376
.
Citations:
2
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Sabe H,
Shoelson SE
, Hanafusa H. Possible v-Crk-induced transformation through activation of Src kinases. J Biol Chem. 1995 Dec 29; 270(52):31219-24.
PMID:
8537387
.
Citations:
5
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J,
Shoelson SE
. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem. 1995 Nov 17; 270(46):27407-10.
PMID:
7499194
.
Citations:
47
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Ye B, Akamatsu M,
Shoelson SE
, Wolf G, Giorgetti-Peraldi S, Yan X, Roller PP, Burke TR. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. J Med Chem. 1995 Oct 13; 38(21):4270-5.
PMID:
7473554
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Cells
Ravichandran KS, Lorenz U,
Shoelson SE
, Burakoff SJ. Interaction of Shc with Grb2 regulates the Grb2 association with mSOS. Ann N Y Acad Sci. 1995 Sep 07; 766:202-3.
PMID:
7486657
.
Citations:
4
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B,
Cantley L
,
Shoelson SE
, Band H. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem. 1995 Aug 25; 270(34):20177-82.
PMID:
7544353
.
Citations:
19
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B,
Cantley L
,
Shoelson SE
, Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11; 270(32):19141-50.
PMID:
7642581
.
Citations:
32
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Trüb T, Choi WE, Wolf G, Ottinger E, Chen Y, Weiss M,
Shoelson SE
. Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J Biol Chem. 1995 Aug 04; 270(31):18205-8.
PMID:
7543098
.
Citations:
16
Fields:
Bio
Biochemistry
Translation:
Cells
Songyang Z, Margolis B, Chaudhuri M,
Shoelson SE
,
Cantley LC
. The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif. J Biol Chem. 1995 Jun 23; 270(25):14863-6.
PMID:
7541030
.
Citations:
34
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Burke TR, Barchi JJ, George C, Wolf G,
Shoelson SE
, Yan X. Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. J Med Chem. 1995 Apr 14; 38(8):1386-96.
PMID:
7537333
.
Citations:
4
Fields:
Che
Chemistry
Translation:
Cells
Schneider H, Cai YC, Prasad KV,
Shoelson SE
, Rudd CE. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur J Immunol. 1995 Apr; 25(4):1044-50.
PMID:
7737275
.
Citations:
45
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D,
Shoelson S
, Pawson T. A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol. 1995 Apr 01; 5(4):404-12.
PMID:
7542991
.
Citations:
39
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Pluskey S, Wandless TJ, Walsh CT,
Shoelson SE
. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem. 1995 Feb 17; 270(7):2897-900.
PMID:
7531695
.
Citations:
68
Fields:
Bio
Biochemistry
Translation:
Cells
Yamada K, Carpentier JL, Cheatham B, Goncalves E,
Shoelson SE
,
Kahn CR
. Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor. J Biol Chem. 1995 Feb 17; 270(7):3115-22.
PMID:
7852393
.
Citations:
5
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Ravichandran KS, Lorenz U,
Shoelson SE
, Burakoff SJ. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol. 1995 Feb; 15(2):593-600.
PMID:
7529871
.
Citations:
33
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Yamada K, Goncalves E, Carpentier JL,
Kahn CR
,
Shoelson SE
. Transmembrane domain inversion blocks ER release and insulin receptor signaling. Biochemistry. 1995 Jan 24; 34(3):946-54.
PMID:
7827053
.
Citations:
1
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Schneider H, Prasad KV,
Shoelson SE
, Rudd CE. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J Exp Med. 1995 Jan 01; 181(1):351-5.
PMID:
7807015
; PMCID:
PMC2191832
.
Citations:
41
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Humans
Cells
Garcia P,
Shoelson SE
, Drew JS, Miller WT. Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity. J Biol Chem. 1994 Dec 02; 269(48):30574-9.
PMID:
7527032
.
Citations:
6
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Li SC, Deber CM,
Shoelson SE
. An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization. Biochemistry. 1994 Nov 29; 33(47):14333-8.
PMID:
7947843
.
Citations:
3
Fields:
Bio
Biochemistry
Translation:
Cells
Payne G, Stolz LA, Pei D, Band H,
Shoelson SE
, Walsh CT. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct; 1(2):99-105.
PMID:
9383377
.
Citations:
10
Fields:
Bio
Biochemistry
Bio
Biology
Che
Chemistry
Translation:
Humans
Cells
Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K,
Shoelson S
, Songyang Z,
Cantley L
, Walsh C, Band H. Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn. Mol Cell Biol. 1994 Sep; 14(9):6372-85.
PMID:
7520528
.
Citations:
16
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP,
Shoelson SE
, Olefsky JM. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem. 1994 Aug 19; 269(33):21244-8.
PMID:
8063747
.
Citations:
45
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Burke TR, Nomizu M, Otaka A, Smyth MS, Roller PP, Case RD, Wolf G,
Shoelson SE
. Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. Biochem Biophys Res Commun. 1994 Jun 30; 201(3):1148-53.
PMID:
8024556
.
Citations:
2
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Cells
Burke TR, Smyth MS, Otaka A, Nomizu M, Roller PP, Wolf G, Case R,
Shoelson SE
. Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors. Biochemistry. 1994 May 31; 33(21):6490-4.
PMID:
7515682
.
Citations:
24
Fields:
Bio
Biochemistry
Translation:
Cells
Farrow NA, Muhandiram R, Singer AU, Pascal SM, Kay CM, Gish G,
Shoelson SE
, Pawson T, Forman-Kay JD, Kay LE. Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry. 1994 May 17; 33(19):5984-6003.
PMID:
7514039
.
Citations:
869
Fields:
Bio
Biochemistry
Translation:
Cells
Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J,
Shoelson SE
, Kuriyan J. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure. 1994 May 15; 2(5):423-38.
PMID:
7521735
.
Citations:
46
Fields:
Bio
Biochemistry
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Animals
Cells
Reedquist KA, Fukazawa T, Druker B, Panchamoorthy G,
Shoelson SE
, Band H. Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4135-9.
PMID:
7514295
; PMCID:
PMC43739
.
Citations:
19
Fields:
Sci
Science
Translation:
Humans
Cells
Sugimoto S, Wandless TJ,
Shoelson SE
, Neel BG, Walsh CT. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J Biol Chem. 1994 May 06; 269(18):13614-22.
PMID:
7513703
.
Citations:
53
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Pascal SM, Singer AU, Gish G, Yamazaki T,
Shoelson SE
, Pawson T, Kay LE, Forman-Kay JD. Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell. 1994 May 06; 77(3):461-72.
PMID:
8181064
.
Citations:
49
Fields:
Cel
Cell Biology
Translation:
Cells
Eck MJ
, Atwell SK,
Shoelson SE
,
Harrison SC
. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature. 1994 Apr 21; 368(6473):764-9.
PMID:
7512222
.
Citations:
58
Fields:
Sci
Science
Translation:
Cells
Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG,
Shoelson SE
. SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. J Biol Chem. 1994 Apr 08; 269(14):10467-74.
PMID:
8144631
.
Citations:
22
Fields:
Bio
Biochemistry
Translation:
Cells
Songyang Z,
Shoelson SE
, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol. 1994 Apr; 14(4):2777-85.
PMID:
7511210
.
Citations:
238
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Prasad KV, Cai YC, Raab M, Duckworth B,
Cantley L
,
Shoelson SE
, Rudd CE. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2834-8.
PMID:
8146197
; PMCID:
PMC43465
.
Citations:
79
Fields:
Sci
Science
Translation:
Animals
Cells
Garcia P,
Shoelson SE
, George ST, Hinds DA, Goldberg AR, Miller WT. Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro. J Biol Chem. 1993 Nov 25; 268(33):25146-51.
PMID:
8227078
.
Citations:
14
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Chuang LM, Myers MG, Backer JM,
Shoelson SE
, White MF, Birnbaum MJ,
Kahn CR
. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Mol Cell Biol. 1993 Nov; 13(11):6653-60.
PMID:
8413261
.
Citations:
19
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Williams KP,
Shoelson SE
. Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding. Biochemistry. 1993 Oct 26; 32(42):11279-84.
PMID:
7692962
.
Citations:
7
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Sugimoto S, Lechleider RJ,
Shoelson SE
, Neel BG, Walsh CT. Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. J Biol Chem. 1993 Oct 25; 268(30):22771-6.
PMID:
8226787
.
Citations:
20
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA,
Shoelson SE
, Walsh CT, Neel BG. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J Biol Chem. 1993 Oct 15; 268(29):21478-81.
PMID:
7691811
.
Citations:
71
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Larose L, Gish G,
Shoelson S
, Pawson T. Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. Oncogene. 1993 Sep; 8(9):2493-9.
PMID:
7689724
.
Citations:
7
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Animals
Cells
Cheatham B,
Shoelson SE
, Yamada K, Goncalves E,
Kahn CR
. Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7336-40.
PMID:
7688476
; PMCID:
PMC47132
.
Citations:
13
Fields:
Sci
Science
Translation:
Animals
Cells
Castaño L, Ziegler AG, Ziegler R,
Shoelson S
, Eisenbarth GS. Characterization of insulin autoantibodies in relatives of patients with type I diabetes. Diabetes. 1993 Aug; 42(8):1202-9.
PMID:
8325453
.
Citations:
20
Fields:
End
Endocrinology
Translation:
Humans
Cells
Birge RB, Fajardo JE, Reichman C,
Shoelson SE
, Songyang Z,
Cantley LC
, Hanafusa H. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol. 1993 Aug; 13(8):4648-56.
PMID:
7687742
.
Citations:
81
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Goncalves E, Yamada K, Thatte HS, Backer JM,
Golan DE
,
Kahn CR
,
Shoelson SE
. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5762-6.
PMID:
8390680
; PMCID:
PMC46802
.
Citations:
6
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Payne G,
Shoelson SE
, Gish GD, Pawson T, Walsh CT. Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):4902-6.
PMID:
7685110
; PMCID:
PMC46621
.
Citations:
21
Fields:
Sci
Science
Translation:
Animals
Cells
Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B,
Shoelson S
,
Cantley LC
. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem. 1993 May 05; 268(13):9478-83.
PMID:
7683653
.
Citations:
108
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Backer JM, Myers MG, Sun XJ, Chin DJ,
Shoelson SE
, Miralpeix M, White MF. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem. 1993 Apr 15; 268(11):8204-12.
PMID:
8385139
.
Citations:
34
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J,
Shoelson SE
. Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry. 1993 Apr 06; 32(13):3197-202.
PMID:
8384875
.
Citations:
34
Fields:
Bio
Biochemistry
Translation:
Cells
Williams KP,
Shoelson SE
. A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. J Biol Chem. 1993 Mar 15; 268(8):5361-4.
PMID:
7680644
.
Citations:
5
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Songyang Z,
Shoelson SE
, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al. SH2 domains recognize specific phosphopeptide sequences. Cell. 1993 Mar 12; 72(5):767-78.
PMID:
7680959
.
Citations:
739
Fields:
Cel
Cell Biology
Translation:
Cells
Waksman G,
Shoelson SE
, Pant N, Cowburn D, Kuriyan J. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell. 1993 Mar 12; 72(5):779-90.
PMID:
7680960
.
Citations:
194
Fields:
Cel
Cell Biology
Translation:
Cells
Eck MJ
,
Shoelson SE
,
Harrison SC
. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature. 1993 Mar 04; 362(6415):87-91.
PMID:
7680435
.
Citations:
111
Fields:
Sci
Science
Translation:
Cells
Felder S, Zhou M, Hu P, Ureña J, Ullrich A, Chaudhuri M, White M,
Shoelson SE
, Schlessinger J. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol Cell Biol. 1993 Mar; 13(3):1449-55.
PMID:
7680095
.
Citations:
40
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Shoelson SE
, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. J Biol Chem. 1993 Feb 25; 268(6):4085-91.
PMID:
8382690
.
Citations:
9
Fields:
Bio
Biochemistry
Translation:
Cells
Lee J, O'Hare T, Pilch PF,
Shoelson SE
. Insulin receptor autophosphorylation occurs asymmetrically. J Biol Chem. 1993 Feb 25; 268(6):4092-8.
PMID:
8440700
.
Citations:
12
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Shoelson SE
, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 1993 Feb; 12(2):795-802.
PMID:
8382612
; PMCID:
PMC413268
.
Citations:
38
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Humans
Cells
Hua QX,
Shoelson SE
, Inouye K, Weiss MA. Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):582-6.
PMID:
8421693
; PMCID:
PMC45707
.
Citations:
13
Fields:
Sci
Science
Translation:
Humans
Cells
Kahn CR
, White MF,
Shoelson SE
, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P, et al. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Prog Horm Res. 1993; 48:291-339.
PMID:
7680139
.
Citations:
21
Fields:
End
Endocrinology
Translation:
Humans
Animals
Cells
Hua QX,
Shoelson SE
, Weiss MA. Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition. Biochemistry. 1992 Dec 01; 31(47):11940-51.
PMID:
1445924
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Rhodes CJ, Lincoln B,
Shoelson SE
. Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. J Biol Chem. 1992 Nov 15; 267(32):22719-27.
PMID:
1429623
.
Citations:
24
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Myers MG, Backer JM, Sun XJ,
Shoelson S
, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10350-4.
PMID:
1332046
; PMCID:
PMC50336
.
Citations:
123
Fields:
Sci
Science
Translation:
Animals
Cells
Meyerovitch J, Backer JM, Csermely P,
Shoelson SE
,
Kahn CR
. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 1992 Oct 27; 31(42):10338-44.
PMID:
1420153
.
Citations:
7
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Domchek SM, Auger KR, Chatterjee S, Burke TR,
Shoelson SE
. Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. Biochemistry. 1992 Oct 20; 31(41):9865-70.
PMID:
1382595
.
Citations:
29
Fields:
Bio
Biochemistry
Translation:
Cells
Backer JM, Myers MG,
Shoelson SE
, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 1992 Sep; 11(9):3469-79.
PMID:
1380456
; PMCID:
PMC556882
.
Citations:
244
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Animals
Cells
Backer JM,
Shoelson SE
, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. J Cell Biol. 1992 Aug; 118(4):831-9.
PMID:
1500426
; PMCID:
PMC2289561
.
Citations:
25
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Yamada K, Goncalves E,
Kahn CR
,
Shoelson SE
. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. J Biol Chem. 1992 Jun 25; 267(18):12452-61.
PMID:
1352286
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Auger KR, Carpenter CL,
Shoelson SE
, Piwnica-Worms H,
Cantley LC
. Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15.
PMID:
1372000
.
Citations:
28