Harvard Catalyst Profiles

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Steven E. Shoelson, M.D., PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK112153 (SHOELSON, STEVEN E) May 2, 2018 - Mar 31, 2022
    NIH/NIDDK
    Feeding Drives HSF1 Transcriptional Programs Required for Global Protein Synthesis
    Role: Principal Investigator
  2. R01HL133329 (SHOELSON, STEVEN E) May 20, 2016 - Mar 31, 2020
    NIH/NHLBI
    Intrinsic anti-inflammatory actions of AMPK activation rendered through a novel immunometabolic AMPK-mTOR-NFkB Pathway
    Role: Principal Investigator
  3. R01DK108936 (SHOELSON, STEVEN E) May 16, 2016 - Mar 31, 2019
    NIH/NIDDK
    Xanthine oxidase inhibition raises intracellular purines to activate AMPK, improve glucose control and decrease fatty liver and atherosclerosis in type 2 diabetes
    Role: Principal Investigator
  4. R01DK095327 (SHOELSON, STEVEN E) Apr 1, 2014 - Mar 31, 2017
    NIH/NIDDK
    Targeting Neutrophils and Leukotrienes to Treat Type 2 Diabetes
    Role: Principal Investigator
  5. RC4DK090792 (SHOELSON, STEVEN E) Sep 30, 2010 - Sep 29, 2012
    NIH/NIDDK
    Mechanism-Based Biomarkers for Glucose-Lowering in TINSAL-T2D
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H. Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Commun Biol. 2019; 2:76. PMID: 30820471.
    Citations:    
  2. Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N. NF?B Regulates Muscle Development and Mitochondrial Function. J Gerontol A Biol Sci Med Sci. 2018 11 13. PMID: 30423026.
    Citations:    Fields:    
  3. Salastekar N, Desai T, Hauser T, Schaefer EJ, Fowler K, Joseph S, Shoelson SE, Goldfine AB. Salsalate improves glycaemia in overweight persons with diabetes risk factors of stable statin-treated cardiovascular disease: A 30-month randomized placebo-controlled trial. Diabetes Obes Metab. 2017 10; 19(10):1458-1462. PMID: 28295931.
    Citations: 1     Fields:    Translation:Humans
  4. Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N. Sustained NF?B inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell. 2017 08; 16(4):847-858. PMID: 28556540.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Woo JR, Kim SJ, Kim KY, Jang H, Shoelson SE, Park S. The carboxy-terminal region of the TBC1D4 (AS160) RabGAP mediates protein homodimerization. Int J Biol Macromol. 2017 Oct; 103:965-971. PMID: 28545963.
    Citations: 1     Fields:    Translation:HumansCells
  6. Goldfine AB, Shoelson SE. Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk. J Clin Invest. 2017 01 03; 127(1):83-93. PMID: 28045401.
    Citations: 4     Fields:    Translation:HumansAnimals
  7. Oh J, Sinha I, Tan KY, Rosner B, Dreyfuss JM, Gjata O, Tran P, Shoelson SE, Wagers AJ. Age-associated NF-?B signaling in myofibers alters the satellite cell niche and re-strains muscle stem cell function. Aging (Albany NY). 2016 11 14; 8(11):2871-2896. PMID: 27852976.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Hauser TH, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM, Weber GM, Welty F, Clouse M, Shoelson SE, Goldfine AB. Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. JAMA Cardiol. 2016 07 01; 1(4):413-23. PMID: 27438317.
    Citations: 5     Fields:    Translation:Humans
  9. Lee BC, Kim MS, Pae M, Yamamoto Y, Eberlé D, Shimada T, Kamei N, Park HS, Sasorith S, Woo JR, You J, Mosher W, Brady HJ, Shoelson SE, Lee J. Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity. Cell Metab. 2016 Apr 12; 23(4):685-98. PMID: 27050305.
    Citations: 23     Fields:    Translation:AnimalsCells
  10. Rubin MR, Goldfine AB, McMahon DJ, Donovan DS, Cremers S, Dworakowski E, Schaefer EJ, Shoelson SE, Silverberg SJ. Effects of the anti-inflammatory drug salsalate on bone turnover in type 2 diabetes mellitus. Endocrine. 2015 Nov; 50(2):504-7. PMID: 25636441.
    Citations: 2     Fields:    Translation:Humans
  11. Okazaki T, Liang F, Li T, Lemaire C, Danialou G, Shoelson SE, Petrof BJ. Muscle-specific inhibition of the classical nuclear factor-?B pathway is protective against diaphragmatic weakness in murine endotoxemia. Crit Care Med. 2014 Jul; 42(7):e501-9. PMID: 24933061.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Pearce LR, Joe R, Doche ME, Su HW, Keogh JM, Henning E, Argetsinger LS, Bochukova EG, Cline JM, Garg S, Saeed S, Shoelson S, O'Rahilly S, Barroso I, Rui L, Farooqi IS, Carter-Su C. Functional characterization of obesity-associated variants involving the a and ß isoforms of human SH2B1. Endocrinology. 2014 Sep; 155(9):3219-26. PMID: 24971614.
    Citations: 9     Fields:    Translation:HumansCells
  13. Lee J, Miyazaki M, Romeo GR, Shoelson SE. Insulin receptor activation with transmembrane domain ligands. J Biol Chem. 2014 Jul 11; 289(28):19769-77. PMID: 24867955.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Goldfine AB, Jablonski KA, Shoelson SE, Creager MA. Response to comment on Goldfine et al. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes care 2013;36:4132-4139. Diabetes Care. 2014 May; 37(5):e112. PMID: 24757239.
    Citations:    Fields:    Translation:Humans
  15. Kim MS, Yamamoto Y, Kim K, Kamei N, Shimada T, Liu L, Moore K, Woo JR, Shoelson SE, Lee J. Regulation of diet-induced adipose tissue and systemic inflammation by salicylates and pioglitazone. PLoS One. 2013; 8(12):e82847. PMID: 24376593.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Barzilay JI, Jablonski KA, Fonseca V, Shoelson SE, Goldfine AB, Strauch C, Monnier VM. The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes. Diabetes Care. 2014 Apr; 37(4):1083-91. PMID: 24255104.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  17. King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes. PLoS One. 2013; 8(10):e77452. PMID: 24204831.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Goldfine AB, Buck JS, Desouza C, Fonseca V, Chen YD, Shoelson SE, Jablonski KA, Creager MA. Targeting inflammation using salsalate in patients with type 2 diabetes: effects on flow-mediated dilation (TINSAL-FMD). Diabetes Care. 2013 Dec; 36(12):4132-9. PMID: 24130358.
    Citations: 13     Fields:    Translation:Humans
  19. Romeo GR, Pae M, Eberlé D, Lee J, Shoelson SE. Profilin-1 haploinsufficiency protects against obesity-associated glucose intolerance and preserves adipose tissue immune homeostasis. Diabetes. 2013 Nov; 62(11):3718-26. PMID: 23884883.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Goldfine AB, Fonseca V, Jablonski KA, Chen YD, Tipton L, Staten MA, Shoelson SE. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2013 Jul 02; 159(1):1-12. PMID: 23817699.
    Citations: 62     Fields:    Translation:HumansCTClinical Trials
  21. Goldfine AB, Conlin PR, Halperin F, Koska J, Permana P, Schwenke D, Shoelson SE, Reaven PD. A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance. Diabetologia. 2013 Apr; 56(4):714-23. PMID: 23370525.
    Citations: 36     Fields:    Translation:Humans
  22. Mima A, Qi W, Hiraoka-Yamomoto J, Park K, Matsumoto M, Kitada M, Li Q, Mizutani K, Yu E, Shimada T, Lee J, Shoelson SE, Jobin C, Rask-Madsen C, King GL. Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes. Invest Ophthalmol Vis Sci. 2012 Dec 19; 53(13):8424-32. PMID: 23197686.
    Citations: 7     Fields:    Translation:Animals
  23. Romeo GR, Lee J, Shoelson SE. Metabolic syndrome, insulin resistance, and roles of inflammation--mechanisms and therapeutic targets. Arterioscler Thromb Vasc Biol. 2012 Aug; 32(8):1771-6. PMID: 22815343.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  24. Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D. PPAR-? is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012 Jun 28; 486(7404):549-53. PMID: 22722857.
    Citations: 259     Fields:    Translation:AnimalsCells
  25. Schakman O, Dehoux M, Bouchuari S, Delaere S, Lause P, Decroly N, Shoelson SE, Thissen JP. Role of IGF-I and the TNFa/NF-?B pathway in the induction of muscle atrogenes by acute inflammation. Am J Physiol Endocrinol Metab. 2012 Sep 15; 303(6):E729-39. PMID: 22739109.
    Citations: 16     Fields:    Translation:AnimalsCells
  26. Langen RC, Haegens A, Vernooy JH, Wouters EF, de Winther MP, Carlsen H, Steele C, Shoelson SE, Schols AM. NF-?B activation is required for the transition of pulmonary inflammation to muscle atrophy. Am J Respir Cell Mol Biol. 2012 Sep; 47(3):288-97. PMID: 22538866.
    Citations: 20     Fields:    Translation:AnimalsCells
  27. Haegens A, Schols AM, Gorissen SH, van Essen AL, Snepvangers F, Gray DA, Shoelson SE, Langen RC. NF-?B activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy. Am J Physiol Lung Cell Mol Physiol. 2012 Jan 01; 302(1):L103-10. PMID: 22003096.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  28. van Diepen JA, Vroegrijk IO, Berbée JF, Shoelson SE, Romijn JA, Havekes LM, Rensen PC, Voshol PJ. Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet. Am J Physiol Endocrinol Metab. 2011 Dec; 301(6):E1099-107. PMID: 21862721.
    Citations: 6     Fields:    Translation:AnimalsCells
  29. Wong MC, van Diepen JA, Hu L, Guigas B, de Boer HC, van Puijvelde GH, Kuiper J, van Zonneveld AJ, Shoelson SE, Voshol PJ, Romijn JA, Havekes LM, Tamsma JT, Rensen PC, Hiemstra PS, Berbée JF. Hepatocyte-specific IKKß expression aggravates atherosclerosis development in APOE*3-Leiden mice. Atherosclerosis. 2012 Feb; 220(2):362-8. PMID: 21798539.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  30. Park SY, Jin W, Woo JR, Shoelson SE. Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. J Biol Chem. 2011 May 20; 286(20):18130-8. PMID: 21454505.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  31. van Diepen JA, Wong MC, Guigas B, Bos J, Stienstra R, Hodson L, Shoelson SE, Berbée JF, Rensen PC, Romijn JA, Havekes LM, Voshol PJ. Hepatocyte-specific IKK-ß activation enhances VLDL-triglyceride production in APOE*3-Leiden mice. J Lipid Res. 2011 May; 52(5):942-50. PMID: 21357939.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  32. Mathis D, Shoelson SE. Immunometabolism: an emerging frontier. Nat Rev Immunol. 2011 Feb; 11(2):81. PMID: 21469396.
    Citations: 88     Fields:    Translation:HumansCells
  33. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011 Feb; 11(2):98-107. PMID: 21233852.
    Citations: 624     Fields:    Translation:Humans
  34. Goldfine AB, Fonseca V, Shoelson SE. Therapeutic approaches to target inflammation in type 2 diabetes. Clin Chem. 2011 Feb; 57(2):162-7. PMID: 21098138.
    Citations: 25     Fields:    Translation:HumansAnimals
  35. Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann Intern Med. 2010 Mar 16; 152(6):346-57. PMID: 20231565.
    Citations: 135     Fields:    Translation:Humans
  36. Naour N, Rouault C, Fellahi S, Lavoie ME, Poitou C, Keophiphath M, Eberlé D, Shoelson S, Rizkalla S, Bastard JP, Rabasa-Lhoret R, Clément K, Guerre-Millo M. Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation. J Clin Endocrinol Metab. 2010 Apr; 95(4):1861-8. PMID: 20164293.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  37. Herrero L, Shapiro H, Nayer A, Lee J, Shoelson SE. Inflammation and adipose tissue macrophages in lipodystrophic mice. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):240-5. PMID: 20007767.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  38. Rha GB, Wu G, Shoelson SE, Chi YI. Multiple binding modes between HNF4alpha and the LXXLL motifs of PGC-1alpha lead to full activation. J Biol Chem. 2009 Dec 11; 284(50):35165-76. PMID: 19846556.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  39. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009 Aug; 15(8):930-9. PMID: 19633656.
    Citations: 552     Fields:    Translation:AnimalsCells
  40. Goldfine AB, Shoelson SE, Aguirre V. Expansion and contraction: treating diabetes with bariatric surgery. Nat Med. 2009 Jun; 15(6):616-7. PMID: 19498374.
    Citations: 13     Fields:    Translation:Humans
  41. Shoelson SE, Goldfine AB. Getting away from glucose: fanning the flames of obesity-induced inflammation. Nat Med. 2009 Apr; 15(4):373-4. PMID: 19350009.
    Citations: 43     Fields:    Translation:Humans
  42. Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D, Shoelson SE, Gozani O, Kingston RE, Benoist C, Mathis D. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83. PMID: 18840680.
    Citations: 69     Fields:    Translation:AnimalsCells
  43. Goldfine AB, Silver R, Aldhahi W, Cai D, Tatro E, Lee J, Shoelson SE. Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes. Clin Transl Sci. 2008 May; 1(1):36-43. PMID: 19337387.
    Citations: 101     Fields:    Translation:HumansCTClinical Trials
  44. Park SY, Shoelson SE. When a domain is not a domain. Nat Struct Mol Biol. 2008 Mar; 15(3):224-6. PMID: 18319738.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  45. Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care. 2008 Feb; 31(2):289-94. PMID: 17959861.
    Citations: 106     Fields:    Translation:Humans
  46. Abedini A, Shoelson SE. Inflammation and obesity: STAMPing out insulin resistance? Immunol Cell Biol. 2007 Aug-Sep; 85(6):399-400. PMID: 17646847.
    Citations: 5     Fields:    Translation:HumansAnimals
  47. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology. 2007 May; 132(6):2169-80. PMID: 17498510.
    Citations: 412     Fields:    Translation:HumansAnimals
  48. Shoelson SE. Point-counterpoint: Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol (1985). 2007 Feb; 102(2):820; author reply 825. PMID: 17323463.
    Citations: 2     Fields:    Translation:HumansAnimals
  49. Boonyasrisawat W, Eberle D, Bacci S, Zhang YY, Nolan D, Gervino EV, Johnstone MT, Trischitta V, Shoelson SE, Doria A. Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes. Diabetes. 2007 Feb; 56(2):499-505. PMID: 17259397.
    Citations: 29     Fields:    Translation:Humans
  50. Shoelson SE. Banking on ATM as a new target in metabolic syndrome. Cell Metab. 2006 Nov; 4(5):337-8. PMID: 17084707.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006 Jul; 116(7):1793-801. PMID: 16823477.
    Citations: 1030     Fields:    Translation:HumansCells
  52. Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C794-801. PMID: 15888549.
    Citations: 31     Fields:    Translation:AnimalsCells
  53. Nishi M, Werner ED, Oh BC, Frantz JD, Dhe-Paganon S, Hansen L, Lee J, Shoelson SE. Kinase activation through dimerization by human SH2-B. Mol Cell Biol. 2005 Apr; 25(7):2607-21. PMID: 15767667.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  54. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005 Feb; 11(2):183-90. PMID: 15685173.
    Citations: 598     Fields:    Translation:HumansAnimalsCells
  55. Cai D, Frantz JD, Tawa NE, Melendez PA, Oh BC, Lidov HG, Hasselgren PO, Frontera WR, Lee J, Glass DJ, Shoelson SE. IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. Cell. 2004 Oct 15; 119(2):285-98. PMID: 15479644.
    Citations: 371     Fields:    Translation:HumansAnimalsCells
  56. Dhe-Paganon S, Werner ED, Nishi M, Hansen L, Chi YI, Shoelson SE. A phenylalanine zipper mediates APS dimerization. Nat Struct Mol Biol. 2004 Oct; 11(10):968-74. PMID: 15378031.
    Citations: 20     Fields:    Translation:HumansCells
  57. Werner ED, Lee J, Hansen L, Yuan M, Shoelson SE. Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302. J Biol Chem. 2004 Aug 20; 279(34):35298-305. PMID: 15199052.
    Citations: 72     Fields:    Translation:AnimalsCells
  58. Duda K, Chi YI, Shoelson SE. Structural basis for HNF-4alpha activation by ligand and coactivator binding. J Biol Chem. 2004 May 28; 279(22):23311-6. PMID: 14982928.
    Citations: 13     Fields:    Translation:HumansCells
  59. Shoelson SE, Lee J, Yuan M. Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance. Int J Obes Relat Metab Disord. 2003 Dec; 27 Suppl 3:S49-52. PMID: 14704745.
    Citations: 110     Fields:    Translation:HumansAnimals
  60. Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE. Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem. 2003 Jul 11; 278(28):25323-30. PMID: 12730241.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  61. Kim KA, Kang K, Chi YI, Chang I, Lee MK, Kim KW, Shoelson SE, Lee MS. Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1alpha gene in a Korean family with MODY3. Diabetologia. 2003 May; 46(5):721-7. PMID: 12712243.
    Citations: 6     Fields:    Translation:HumansCells
  62. Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, Shoelson SE, Liu F. Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem. 2003 Mar 07; 278(10):8460-7. PMID: 12493740.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  63. Chi YI, Frantz JD, Oh BC, Hansen L, Dhe-Paganon S, Shoelson SE. Diabetes mutations delineate an atypical POU domain in HNF-1alpha. Mol Cell. 2002 Nov; 10(5):1129-37. PMID: 12453420.
    Citations: 23     Fields:    Translation:HumansCells
  64. Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem. 2002 Nov 01; 277(44):42394-8. PMID: 12228220.
    Citations: 244     Fields:    Translation:HumansAnimals
  65. Dhe-Paganon S, Duda K, Iwamoto M, Chi YI, Shoelson SE. Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand. J Biol Chem. 2002 Oct 11; 277(41):37973-6. PMID: 12193589.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  66. Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest. 2002 May; 109(10):1321-6. PMID: 12021247.
    Citations: 162     Fields:    Translation:Humans
  67. Menzaghi C, Plengvidhya N, Ma X, Warram JH, Shoelson SE, Doria A. Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes. J Clin Endocrinol Metab. 2002 Apr; 87(4):1894-7. PMID: 11932336.
    Citations:    Fields:    Translation:Humans
  68. Dhe-Paganon S, Werner ED, Chi YI, Shoelson SE. Structure of the globular tail of nuclear lamin. J Biol Chem. 2002 May 17; 277(20):17381-4. PMID: 11901143.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  69. Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem. 2002 Jan 11; 277(2):1531-7. PMID: 11606564.
    Citations: 247     Fields:    Translation:HumansAnimalsCells
  70. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science. 2001 Aug 31; 293(5535):1673-7. PMID: 11533494.
    Citations: 506     Fields:    Translation:AnimalsCells
  71. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest. 2001 Aug; 108(3):437-46. PMID: 11489937.
    Citations: 179     Fields:    Translation:AnimalsCells
  72. Lindholm CK, Frantz JD, Shoelson SE, Welsh M. Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor regulation of apoptosis. Biochem Biophys Res Commun. 2000 Nov 30; 278(3):537-43. PMID: 11095946.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  73. Dhe-Paganon S, Shigeta R, Chi YI, Ristow M, Shoelson SE. Crystal structure of human frataxin. J Biol Chem. 2000 Oct 06; 275(40):30753-6. PMID: 10900192.
    Citations: 51     Fields:    Translation:HumansCells
  74. O'Reilly AM, Pluskey S, Shoelson SE, Neel BG. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol. 2000 Jan; 20(1):299-311. PMID: 10594032.
    Citations: 32     Fields:    Translation:AnimalsCells
  75. Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE. Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8378-83. PMID: 10411883.
    Citations: 16     Fields:    Translation:HumansCells
  76. Rapoport I, Chen YC, Cupers P, Shoelson SE, Kirchhausen T. Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site. EMBO J. 1998 Apr 15; 17(8):2148-55. PMID: 9545228.
    Citations: 77     Fields:    Translation:AnimalsCells
  77. Bjørbaek C, Elmquist JK, Frantz JD, Shoelson SE, Flier JS. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell. 1998 Mar; 1(4):619-25. PMID: 9660946.
    Citations: 198     Fields:    Translation:AnimalsCells
  78. Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 1998 Feb 20; 92(4):441-50. PMID: 9491886.
    Citations: 169     Fields:    Translation:HumansCells
  79. Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE. Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins. Oncogene. 1998 Feb 19; 16(7):891-901. PMID: 9484780.
    Citations: 9     Fields:    Translation:HumansCells
  80. Kay LE, Muhandiram DR, Wolf G, Shoelson SE, Forman-Kay JD. Correlation between binding and dynamics at SH2 domain interfaces. Nat Struct Biol. 1998 Feb; 5(2):156-63. PMID: 9461082.
    Citations: 31     Fields:    Translation:Cells
  81. Ottinger EA, Botfield MC, Shoelson SE. Tandem SH2 domains confer high specificity in tyrosine kinase signaling. J Biol Chem. 1998 Jan 09; 273(2):729-35. PMID: 9422724.
    Citations: 44     Fields:    Translation:HumansCells
  82. Lupher ML, Songyang Z, Shoelson SE, Cantley LC, Band H. The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70. J Biol Chem. 1997 Dec 26; 272(52):33140-4. PMID: 9407100.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  83. Shoelson SE. SH2 and PTB domain interactions in tyrosine kinase signal transduction. Curr Opin Chem Biol. 1997 Aug; 1(2):227-34. PMID: 9667855.
    Citations: 13     Fields:    Translation:HumansCells
  84. Rapoport I, Miyazaki M, Boll W, Duckworth B, Cantley LC, Shoelson S, Kirchhausen T. Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes. EMBO J. 1997 May 01; 16(9):2240-50. PMID: 9171339.
    Citations: 61     Fields:    Translation:AnimalsCells
  85. Lee J, Pilch PF, Shoelson SE, Scarlata SF. Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry. 1997 Mar 04; 36(9):2701-8. PMID: 9054578.
    Citations: 6     Fields:    Translation:AnimalsCells
  86. Giorgetti-Peraldi S, Ottinger E, Wolf G, Ye B, Burke TR, Shoelson SE. Cellular effects of phosphotyrosine-binding domain inhibitors on insulin receptor signaling and trafficking. Mol Cell Biol. 1997 Mar; 17(3):1180-8. PMID: 9032245.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  87. Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE. Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains. J Biol Chem. 1997 Jan 31; 272(5):2659-67. PMID: 9006901.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  88. Trüb T, Frantz JD, Miyazaki M, Band H, Shoelson SE. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem. 1997 Jan 10; 272(2):894-902. PMID: 8995379.
    Citations: 33     Fields:    Translation:AnimalsCells
  89. Ricketts WA, Rose DW, Shoelson S, Olefsky JM. Functional roles of the Shc phosphotyrosine binding and Src homology 2 domains in insulin and epidermal growth factor signaling. J Biol Chem. 1996 Oct 18; 271(42):26165-9. PMID: 8824262.
    Citations: 4     Fields:    Translation:AnimalsCells
  90. Sawasdikosol S, Chang JH, Pratt JC, Wolf G, Shoelson SE, Burakoff SJ. Tyrosine-phosphorylated Cbl binds to Crk after T cell activation. J Immunol. 1996 Jul 01; 157(1):110-6. PMID: 8683103.
    Citations: 6     Fields:    Translation:AnimalsCells
  91. Eck MJ, Dhe-Paganon S, Trüb T, Nolte RT, Shoelson SE. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell. 1996 May 31; 85(5):695-705. PMID: 8646778.
    Citations: 58     Fields:    Translation:HumansCells
  92. Ravichandran KS, Igras V, Shoelson SE, Fesik SW, Burakoff SJ. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5275-80. PMID: 8643566.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  93. Pratt JC, Weiss M, Sieff CA, Shoelson SE, Burakoff SJ, Ravichandran KS. Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem. 1996 May 24; 271(21):12137-40. PMID: 8647804.
    Citations: 14     Fields:    Translation:AnimalsCells
  94. Reedquist KA, Fukazawa T, Panchamoorthy G, Langdon WY, Shoelson SE, Druker BJ, Band H. Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G. J Biol Chem. 1996 Apr 05; 271(14):8435-42. PMID: 8626543.
    Citations: 26     Fields:    Translation:HumansCells
  95. Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nat Struct Biol. 1996 Apr; 3(4):364-74. PMID: 8599763.
    Citations: 30     Fields:    Translation:HumansCells
  96. Zhou MM, Huang B, Olejniczak ET, Meadows RP, Shuker SB, Miyazaki M, Trüb T, Shoelson SE, Fesik SW. Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat Struct Biol. 1996 Apr; 3(4):388-93. PMID: 8599766.
    Citations: 28     Fields:    Translation:Cells
  97. Burke TR, Ye B, Akamatsu M, Ford H, Yan X, Kole HK, Wolf G, Shoelson SE, Roller PP. 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine: a phosphotyrosyl mimic for the preparation of signal transduction inhibitory peptides. J Med Chem. 1996 Mar 01; 39(5):1021-7. PMID: 8676336.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  98. Panchamoorthy G, Fukazawa T, Miyake S, Soltoff S, Reedquist K, Druker B, Shoelson S, Cantley L, Band H. p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1996 Feb 09; 271(6):3187-94. PMID: 8621719.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  99. Eck MJ, Pluskey S, Trüb T, Harrison SC, Shoelson SE. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature. 1996 Jan 18; 379(6562):277-80. PMID: 8538796.
    Citations: 40     Fields:    Translation:HumansCells
  100. Sabe H, Shoelson SE, Hanafusa H. Possible v-Crk-induced transformation through activation of Src kinases. J Biol Chem. 1995 Dec 29; 270(52):31219-24. PMID: 8537387.
    Citations: 5     Fields:    Translation:AnimalsCells
  101. Lee J, Shoelson SE, Pilch PF. Intermolecular phosphorylation between insulin holoreceptors does not stimulate substrate kinase activity. J Biol Chem. 1995 Dec 29; 270(52):31136-40. PMID: 8537376.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  102. Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem. 1995 Nov 17; 270(46):27407-10. PMID: 7499194.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  103. Ye B, Akamatsu M, Shoelson SE, Wolf G, Giorgetti-Peraldi S, Yan X, Roller PP, Burke TR. L-O-(2-malonyl)tyrosine: a new phosphotyrosyl mimetic for the preparation of Src homology 2 domain inhibitory peptides. J Med Chem. 1995 Oct 13; 38(21):4270-5. PMID: 7473554.
    Citations: 2     Fields:    Translation:Cells
  104. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates the Grb2 association with mSOS. Ann N Y Acad Sci. 1995 Sep 07; 766:202-3. PMID: 7486657.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  105. Fukazawa T, Reedquist KA, Panchamoorthy G, Soltoff S, Trub T, Druker B, Cantley L, Shoelson SE, Band H. T cell activation-dependent association between the p85 subunit of the phosphatidylinositol 3-kinase and Grb2/phospholipase C-gamma 1-binding phosphotyrosyl protein pp36/38. J Biol Chem. 1995 Aug 25; 270(34):20177-82. PMID: 7544353.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  106. Fukazawa T, Reedquist KA, Trub T, Soltoff S, Panchamoorthy G, Druker B, Cantley L, Shoelson SE, Band H. The SH3 domain-binding T cell tyrosyl phosphoprotein p120. Demonstration of its identity with the c-cbl protooncogene product and in vivo complexes with Fyn, Grb2, and phosphatidylinositol 3-kinase. J Biol Chem. 1995 Aug 11; 270(32):19141-50. PMID: 7642581.
    Citations: 31     Fields:    Translation:HumansCells
  107. Trüb T, Choi WE, Wolf G, Ottinger E, Chen Y, Weiss M, Shoelson SE. Specificity of the PTB domain of Shc for beta turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J Biol Chem. 1995 Aug 04; 270(31):18205-8. PMID: 7543098.
    Citations: 16     Fields:    Translation:Cells
  108. Songyang Z, Margolis B, Chaudhuri M, Shoelson SE, Cantley LC. The phosphotyrosine interaction domain of SHC recognizes tyrosine-phosphorylated NPXY motif. J Biol Chem. 1995 Jun 23; 270(25):14863-6. PMID: 7541030.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  109. Burke TR, Barchi JJ, George C, Wolf G, Shoelson SE, Yan X. Conformationally constrained phosphotyrosyl mimetics designed as monomeric Src homology 2 domain inhibitors. J Med Chem. 1995 Apr 14; 38(8):1386-96. PMID: 7537333.
    Citations: 3     Fields:    Translation:Cells
  110. Schneider H, Cai YC, Prasad KV, Shoelson SE, Rudd CE. T cell antigen CD28 binds to the GRB-2/SOS complex, regulators of p21ras. Eur J Immunol. 1995 Apr; 25(4):1044-50. PMID: 7737275.
    Citations: 34     Fields:    Translation:HumansCells
  111. van der Geer P, Wiley S, Lai VK, Olivier JP, Gish GD, Stephens R, Kaplan D, Shoelson S, Pawson T. A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides. Curr Biol. 1995 Apr 01; 5(4):404-12. PMID: 7542991.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  112. Pluskey S, Wandless TJ, Walsh CT, Shoelson SE. Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem. 1995 Feb 17; 270(7):2897-900. PMID: 7531695.
    Citations: 46     Fields:    Translation:Cells
  113. Yamada K, Carpentier JL, Cheatham B, Goncalves E, Shoelson SE, Kahn CR. Role of the transmembrane domain and flanking amino acids in internalization and down-regulation of the insulin receptor. J Biol Chem. 1995 Feb 17; 270(7):3115-22. PMID: 7852393.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  114. Ravichandran KS, Lorenz U, Shoelson SE, Burakoff SJ. Interaction of Shc with Grb2 regulates association of Grb2 with mSOS. Mol Cell Biol. 1995 Feb; 15(2):593-600. PMID: 7529871.
    Citations: 28     Fields:    Translation:AnimalsCells
  115. Yamada K, Goncalves E, Carpentier JL, Kahn CR, Shoelson SE. Transmembrane domain inversion blocks ER release and insulin receptor signaling. Biochemistry. 1995 Jan 24; 34(3):946-54. PMID: 7827053.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  116. Schneider H, Prasad KV, Shoelson SE, Rudd CE. CTLA-4 binding to the lipid kinase phosphatidylinositol 3-kinase in T cells. J Exp Med. 1995 Jan 01; 181(1):351-5. PMID: 7807015.
    Citations: 35     Fields:    Translation:HumansCells
  117. Garcia P, Shoelson SE, Drew JS, Miller WT. Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity. J Biol Chem. 1994 Dec 02; 269(48):30574-9. PMID: 7527032.
    Citations: 4     Fields:    Translation:AnimalsCells
  118. Li SC, Deber CM, Shoelson SE. An irregularity in the transmembrane domain helix correlates with the rate of insulin receptor internalization. Biochemistry. 1994 Nov 29; 33(47):14333-8. PMID: 7947843.
    Citations: 3     Fields:    Translation:Cells
  119. Payne G, Stolz LA, Pei D, Band H, Shoelson SE, Walsh CT. The phosphopeptide-binding specificity of Src family SH2 domains. Chem Biol. 1994 Oct; 1(2):99-105. PMID: 9383377.
    Citations: 6     Fields:    Translation:HumansCells
  120. Panchamoorthy G, Fukazawa T, Stolz L, Payne G, Reedquist K, Shoelson S, Songyang Z, Cantley L, Walsh C, Band H. Physical and functional interactions between SH2 and SH3 domains of the Src family protein tyrosine kinase p59fyn. Mol Cell Biol. 1994 Sep; 14(9):6372-85. PMID: 7520528.
    Citations: 16     Fields:    Translation:HumansCells
  121. Xiao S, Rose DW, Sasaoka T, Maegawa H, Burke TR, Roller PP, Shoelson SE, Olefsky JM. Syp (SH-PTP2) is a positive mediator of growth factor-stimulated mitogenic signal transduction. J Biol Chem. 1994 Aug 19; 269(33):21244-8. PMID: 8063747.
    Citations: 43     Fields:    Translation:AnimalsCells
  122. Burke TR, Nomizu M, Otaka A, Smyth MS, Roller PP, Case RD, Wolf G, Shoelson SE. Cyclic peptide inhibitors of phosphatidylinositol 3-kinase p85 SH2 domain binding. Biochem Biophys Res Commun. 1994 Jun 30; 201(3):1148-53. PMID: 8024556.
    Citations: 2     Fields:    Translation:Cells
  123. Burke TR, Smyth MS, Otaka A, Nomizu M, Roller PP, Wolf G, Case R, Shoelson SE. Nonhydrolyzable phosphotyrosyl mimetics for the preparation of phosphatase-resistant SH2 domain inhibitors. Biochemistry. 1994 May 31; 33(21):6490-4. PMID: 7515682.
    Citations: 20     Fields:    Translation:Cells
  124. Farrow NA, Muhandiram R, Singer AU, Pascal SM, Kay CM, Gish G, Shoelson SE, Pawson T, Forman-Kay JD, Kay LE. Backbone dynamics of a free and phosphopeptide-complexed Src homology 2 domain studied by 15N NMR relaxation. Biochemistry. 1994 May 17; 33(19):5984-6003. PMID: 7514039.
    Citations: 707     Fields:    Translation:Cells
  125. Lee CH, Kominos D, Jacques S, Margolis B, Schlessinger J, Shoelson SE, Kuriyan J. Crystal structures of peptide complexes of the amino-terminal SH2 domain of the Syp tyrosine phosphatase. Structure. 1994 May 15; 2(5):423-38. PMID: 7521735.
    Citations: 30     Fields:    Translation:AnimalsCells
  126. Reedquist KA, Fukazawa T, Druker B, Panchamoorthy G, Shoelson SE, Band H. Rapid T-cell receptor-mediated tyrosine phosphorylation of p120, an Fyn/Lck Src homology 3 domain-binding protein. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4135-9. PMID: 7514295.
    Citations: 19     Fields:    Translation:HumansCells
  127. Pascal SM, Singer AU, Gish G, Yamazaki T, Shoelson SE, Pawson T, Kay LE, Forman-Kay JD. Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide. Cell. 1994 May 06; 77(3):461-72. PMID: 8181064.
    Citations: 40     Fields:    Translation:Cells
  128. Sugimoto S, Wandless TJ, Shoelson SE, Neel BG, Walsh CT. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J Biol Chem. 1994 May 06; 269(18):13614-22. PMID: 7513703.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  129. Eck MJ, Atwell SK, Shoelson SE, Harrison SC. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature. 1994 Apr 21; 368(6473):764-9. PMID: 7512222.
    Citations: 47     Fields:    Translation:Cells
  130. Case RD, Piccione E, Wolf G, Benett AM, Lechleider RJ, Neel BG, Shoelson SE. SH-PTP2/Syp SH2 domain binding specificity is defined by direct interactions with platelet-derived growth factor beta-receptor, epidermal growth factor receptor, and insulin receptor substrate-1-derived phosphopeptides. J Biol Chem. 1994 Apr 08; 269(14):10467-74. PMID: 8144631.
    Citations: 19     Fields:    Translation:Cells
  131. Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Mol Cell Biol. 1994 Apr; 14(4):2777-85. PMID: 7511210.
    Citations: 215     Fields:    Translation:AnimalsCells
  132. Prasad KV, Cai YC, Raab M, Duckworth B, Cantley L, Shoelson SE, Rudd CE. T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif. Proc Natl Acad Sci U S A. 1994 Mar 29; 91(7):2834-8. PMID: 8146197.
    Citations: 70     Fields:    Translation:AnimalsCells
  133. Garcia P, Shoelson SE, George ST, Hinds DA, Goldberg AR, Miller WT. Phosphorylation of synthetic peptides containing Tyr-Met-X-Met motifs by nonreceptor tyrosine kinases in vitro. J Biol Chem. 1993 Nov 25; 268(33):25146-51. PMID: 8227078.
    Citations: 13     Fields:    Translation:AnimalsCells
  134. Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Mol Cell Biol. 1993 Nov; 13(11):6653-60. PMID: 8413261.
    Citations: 16     Fields:    Translation:AnimalsCells
  135. Williams KP, Shoelson SE. Cooperative self-assembly of SH2 domain fragments restores phosphopeptide binding. Biochemistry. 1993 Oct 26; 32(42):11279-84. PMID: 7692962.
    Citations: 5     Fields:    Translation:HumansCells
  136. Sugimoto S, Lechleider RJ, Shoelson SE, Neel BG, Walsh CT. Expression, purification, and characterization of SH2-containing protein tyrosine phosphatase, SH-PTP2. J Biol Chem. 1993 Oct 25; 268(30):22771-6. PMID: 8226787.
    Citations: 17     Fields:    Translation:HumansCells
  137. Lechleider RJ, Sugimoto S, Bennett AM, Kashishian AS, Cooper JA, Shoelson SE, Walsh CT, Neel BG. Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor. J Biol Chem. 1993 Oct 15; 268(29):21478-81. PMID: 7691811.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  138. Larose L, Gish G, Shoelson S, Pawson T. Identification of residues in the beta platelet-derived growth factor receptor that confer specificity for binding to phospholipase C-gamma 1. Oncogene. 1993 Sep; 8(9):2493-9. PMID: 7689724.
    Citations: 7     Fields:    Translation:AnimalsCells
  139. Castaño L, Ziegler AG, Ziegler R, Shoelson S, Eisenbarth GS. Characterization of insulin autoantibodies in relatives of patients with type I diabetes. Diabetes. 1993 Aug; 42(8):1202-9. PMID: 8325453.
    Citations: 18     Fields:    Translation:HumansCells
  140. Birge RB, Fajardo JE, Reichman C, Shoelson SE, Songyang Z, Cantley LC, Hanafusa H. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol. 1993 Aug; 13(8):4648-56. PMID: 7687742.
    Citations: 77     Fields:    Translation:AnimalsCells
  141. Cheatham B, Shoelson SE, Yamada K, Goncalves E, Kahn CR. Substitution of the erbB-2 oncoprotein transmembrane domain activates the insulin receptor and modulates the action of insulin and insulin-receptor substrate 1. Proc Natl Acad Sci U S A. 1993 Aug 01; 90(15):7336-40. PMID: 7688476.
    Citations: 12     Fields:    Translation:AnimalsCells
  142. Goncalves E, Yamada K, Thatte HS, Backer JM, Golan DE, Kahn CR, Shoelson SE. Optimizing transmembrane domain helicity accelerates insulin receptor internalization and lateral mobility. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5762-6. PMID: 8390680.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  143. Payne G, Shoelson SE, Gish GD, Pawson T, Walsh CT. Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):4902-6. PMID: 7685110.
    Citations: 17     Fields:    Translation:AnimalsCells
  144. Carpenter CL, Auger KR, Chanudhuri M, Yoakim M, Schaffhausen B, Shoelson S, Cantley LC. Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit. J Biol Chem. 1993 May 05; 268(13):9478-83. PMID: 7683653.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  145. Backer JM, Myers MG, Sun XJ, Chin DJ, Shoelson SE, Miralpeix M, White MF. Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem. 1993 Apr 15; 268(11):8204-12. PMID: 8385139.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  146. Piccione E, Case RD, Domchek SM, Hu P, Chaudhuri M, Backer JM, Schlessinger J, Shoelson SE. Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry. 1993 Apr 06; 32(13):3197-202. PMID: 8384875.
    Citations: 28     Fields:    Translation:Cells
  147. Williams KP, Shoelson SE. A photoaffinity scan maps regions of the p85 SH2 domain involved in phosphoprotein binding. J Biol Chem. 1993 Mar 15; 268(8):5361-4. PMID: 7680644.
    Citations: 5     Fields:    Translation:HumansCells
  148. Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al. SH2 domains recognize specific phosphopeptide sequences. Cell. 1993 Mar 12; 72(5):767-78. PMID: 7680959.
    Citations: 653     Fields:    Translation:Cells
  149. Waksman G, Shoelson SE, Pant N, Cowburn D, Kuriyan J. Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell. 1993 Mar 12; 72(5):779-90. PMID: 7680960.
    Citations: 157     Fields:    Translation:Cells
  150. Eck MJ, Shoelson SE, Harrison SC. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature. 1993 Mar 04; 362(6415):87-91. PMID: 7680435.
    Citations: 86     Fields:    Translation:Cells
  151. Felder S, Zhou M, Hu P, Ureña J, Ullrich A, Chaudhuri M, White M, Shoelson SE, Schlessinger J. SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Mol Cell Biol. 1993 Mar; 13(3):1449-55. PMID: 7680095.
    Citations: 35     Fields:    Translation:HumansCells
  152. Shoelson SE, Lee J, Lynch CS, Backer JM, Pilch PF. BpaB25 insulins. Photoactivatable analogues that quantitatively cross-link, radiolabel, and activate the insulin receptor. J Biol Chem. 1993 Feb 25; 268(6):4085-91. PMID: 8382690.
    Citations: 8     Fields:    Translation:Cells
  153. Lee J, O'Hare T, Pilch PF, Shoelson SE. Insulin receptor autophosphorylation occurs asymmetrically. J Biol Chem. 1993 Feb 25; 268(6):4092-8. PMID: 8440700.
    Citations: 10     Fields:    Translation:AnimalsCells
  154. Shoelson SE, Sivaraja M, Williams KP, Hu P, Schlessinger J, Weiss MA. Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO J. 1993 Feb; 12(2):795-802. PMID: 8382612.
    Citations: 36     Fields:    Translation:HumansCells
  155. Hua QX, Shoelson SE, Inouye K, Weiss MA. Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):582-6. PMID: 8421693.
    Citations: 7     Fields:    Translation:HumansCells
  156. Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P, et al. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Prog Horm Res. 1993; 48:291-339. PMID: 7680139.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  157. Hua QX, Shoelson SE, Weiss MA. Nonlocal structural perturbations in a mutant human insulin: sequential resonance assignment and 13C-isotope-aided 2D-NMR studies of [PheB24-->Gly]insulin with implications for receptor recognition. Biochemistry. 1992 Dec 01; 31(47):11940-51. PMID: 1445924.
    Citations: 7     Fields:    Translation:HumansCells
  158. Rhodes CJ, Lincoln B, Shoelson SE. Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing. J Biol Chem. 1992 Nov 15; 267(32):22719-27. PMID: 1429623.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  159. Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10350-4. PMID: 1332046.
    Citations: 108     Fields:    Translation:AnimalsCells
  160. Meyerovitch J, Backer JM, Csermely P, Shoelson SE, Kahn CR. Insulin differentially regulates protein phosphotyrosine phosphatase activity in rat hepatoma cells. Biochemistry. 1992 Oct 27; 31(42):10338-44. PMID: 1420153.
    Citations: 7     Fields:    Translation:AnimalsCells
  161. Domchek SM, Auger KR, Chatterjee S, Burke TR, Shoelson SE. Inhibition of SH2 domain/phosphoprotein association by a nonhydrolyzable phosphonopeptide. Biochemistry. 1992 Oct 20; 31(41):9865-70. PMID: 1382595.
    Citations: 22     Fields:    Translation:Cells
  162. Backer JM, Myers MG, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, et al. Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J. 1992 Sep; 11(9):3469-79. PMID: 1380456.
    Citations: 228     Fields:    Translation:AnimalsCells
  163. Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. J Cell Biol. 1992 Aug; 118(4):831-9. PMID: 1500426.
    Citations: 23     Fields:    Translation:AnimalsCells
  164. Yamada K, Goncalves E, Kahn CR, Shoelson SE. Substitution of the insulin receptor transmembrane domain with the c-neu/erbB2 transmembrane domain constitutively activates the insulin receptor kinase in vitro. J Biol Chem. 1992 Jun 25; 267(18):12452-61. PMID: 1352286.
    Citations: 10     Fields:    Translation:AnimalsCells
  165. Auger KR, Carpenter CL, Shoelson SE, Piwnica-Worms H, Cantley LC. Polyoma virus middle T antigen-pp60c-src complex associates with purified phosphatidylinositol 3-kinase in vitro. J Biol Chem. 1992 Mar 15; 267(8):5408-15. PMID: 1372000.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  166. Shoelson SE, Chatterjee S, Chaudhuri M, White MF. YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2027-31. PMID: 1312712.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  167. Shoelson SE, Lu ZX, Parlautan L, Lynch CS, Weiss MA. Mutations at the dimer, hexamer, and receptor-binding surfaces of insulin independently affect insulin-insulin and insulin-receptor interactions. Biochemistry. 1992 Feb 18; 31(6):1757-67. PMID: 1737029.
    Citations: 14     Fields:    Translation:HumansCells
  168. Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. J Cell Biol. 1991 Dec; 115(6):1535-45. PMID: 1757462.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  169. Hua QX, Shoelson SE, Kochoyan M, Weiss MA. Receptor binding redefined by a structural switch in a mutant human insulin. Nature. 1991 Nov 21; 354(6350):238-41. PMID: 1961250.
    Citations: 47     Fields:    Translation:HumansCells
  170. Shoelson SE, Boni-Schnetzler M, Pilch PF, Kahn CR. Autophosphorylation within insulin receptor beta-subunits can occur as an intramolecular process. Biochemistry. 1991 Aug 06; 30(31):7740-6. PMID: 1651107.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  171. Weiss MA, Hua QX, Lynch CS, Frank BH, Shoelson SE. Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design. Biochemistry. 1991 Jul 30; 30(30):7373-89. PMID: 1906742.
    Citations: 26     Fields:    Translation:HumansCells
  172. Weiss MA, Frank BH, Khait I, Pekar A, Heiney R, Shoelson SE, Neuringer LJ. NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition. Biochemistry. 1990 Sep 11; 29(36):8389-401. PMID: 2252901.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  173. Weiss MA, Nguyen DT, Khait I, Inouye K, Frank BH, Beckage M, O'Shea E, Shoelson SE, Karplus M, Neuringer LJ. Two-dimensional NMR and photo-CIDNP studies of the insulin monomer: assignment of aromatic resonances with application to protein folding, structure, and dynamics. Biochemistry. 1989 Dec 12; 28(25):9855-73. PMID: 2692717.
    Citations: 6     Fields:    Translation:HumansCells
  174. Shoelson SE, White MF, Kahn CR. Nonphosphorylatable substrate analogs selectively block autophosphorylation and activation of the insulin receptor, epidermal growth factor receptor, and pp60v-src kinases. J Biol Chem. 1989 May 15; 264(14):7831-6. PMID: 2498306.
    Citations: 5     Fields:    Translation:Cells
  175. Karasik A, Pepinsky RB, Shoelson SE, Kahn CR. Lipocortins 1 and 2 as substrates for the insulin receptor kinase in rat liver. J Biol Chem. 1988 Aug 25; 263(24):11862-7. PMID: 2457028.
    Citations: 19     Fields:    Translation:AnimalsCells
  176. Shoelson SE, White MF, Kahn CR. Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem. 1988 Apr 05; 263(10):4852-60. PMID: 2832409.
    Citations: 38     Fields:    Translation:Cells
  177. White MF, Shoelson SE, Keutmann H, Kahn CR. A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem. 1988 Feb 25; 263(6):2969-80. PMID: 2449432.
    Citations: 105     Fields:    Translation:HumansCells
  178. Halban PA, Rhodes CJ, Shoelson SE. High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin. Diabetologia. 1986 Dec; 29(12):893-6. PMID: 3552815.
    Citations: 5     Fields:    Translation:Animals
  179. Shoelson SE, Marshall S, Horikoshi H, Kolterman OG, Rubenstein AH, Olefsky JM. Antiinsulin receptor antibodies in an insulin-dependent diabetic may arise as autoantiidiotypes. J Clin Endocrinol Metab. 1986 Jul; 63(1):56-61. PMID: 3486878.
    Citations: 6     Fields:    Translation:HumansCells
  180. Shoelson SE, Polonsky KS, Nakabayashi T, Jaspan JB, Tager HS. Circulating forms of somatostatinlike immunoreactivity in human plasma. Am J Physiol. 1986 Apr; 250(4 Pt 1):E428-34. PMID: 3963183.
    Citations: 2     Fields:    Translation:Humans
  181. Given BD, Cohen RM, Shoelson SE, Frank BH, Rubenstein AH, Tager HS. Biochemical and clinical implications of proinsulin conversion intermediates. J Clin Invest. 1985 Oct; 76(4):1398-405. PMID: 3902891.
    Citations: 12     Fields:    Translation:HumansCells
  182. Robbins DC, Shoelson SE, Tager HS, Mead PM, Gaynor DH. Products of therapeutic insulins in the blood of insulin-dependent (type I) diabetic patients. Diabetes. 1985 May; 34(5):510-9. PMID: 3886464.
    Citations: 3     Fields:    Translation:Humans
  183. Cohen RM, Nakabayashi T, Blix PM, Rue PA, Shoelson SE, Root MA, Frank BH, Revers RR, Rubenstein AH. A radioimmunoassay for circulating human proinsulin. Diabetes. 1985 Jan; 34(1):84-91. PMID: 3880551.
    Citations: