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Justin Baker, M.D.,Ph.D.

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Overview
Justin Baker, M.D., Ph.D., is a clinician-scientist in the Department of Psychiatry at Harvard Medical School and the Schizophrenia and Bipolar Disorder Program at McLean Hospital, where he directs the Laboratory for Functional Neuroimaging and Bioinformatics. His research uses a combination of neuroimaging, genetics, and behavioral phenotyping strategies to understand the systems-level neurobiology of human brain networks in healthy and diseased populations, with a focus on psychotic disorders. Dr. Baker obtained his undergraduate degree from Brown University, and his M.D. and Ph.D. degrees from Washington University in St. Louis, where he studied the oculomotor networks of the macaque monkey using a cortical mapping strategy that bridged insights from single-unit electrophysiology and post-mortem histology to in vivo tract-tracing using manganese-enhanced MRI to awake-behaving fMRI and resting-state fMRI. During his residency in psychiatry with the MGH/McLean program, Dr. Baker completed a postdoctoral fellowship with Dost Öngür (McLean Hospital) and Randy Buckner (Harvard / MGH), spearheading the collection of a large structural and functional neuroimaging data set in a cross-diagnostic sample of patients with schizophrenia or psychotic bipolar disorder. His current work is focused on within-patient (i.e., longitudinal) changes in brain network architecture – both in psychosis and other related clinical phenotypes (e.g.,, ultra-high-risk and early psychosis and bipolar depression) – to gain basic neurobiological insights about the factors that influence illness trajectory and therapeutic response across a range of psychopathology.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01MH116925 (BAKER, JUSTIN T) Aug 3, 2018 - May 31, 2022
    NIH/NIMH
    Robust Predictors of Mania and Psychosis
    Role: Principal Investigator
  2. K23MH104515 (BAKER, JUSTIN T) Sep 1, 2014 - Jun 30, 2019
    NIH/NIMH
    Frontoparietal Network Integrity and Risk for Psychosis
    Role: Principal Investigator
  3. F31NS046247 (BAKER, JUSTIN T) May 1, 2003 - Apr 30, 2005
    NIH/NINDS
    Cortical control of the eye and arm in humans &monkeys
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Baker JT, Dillon DG, Patrick LM, Roffman JL, Brady RO, Pizzagalli DA, Öngür D, Holmes AJ. Functional connectomics of affective and psychotic pathology. Proc Natl Acad Sci U S A. 2019 04 30; 116(18):9050-9059. PMID: 30988201.
    Citations:    
  2. Sisk BA, Canavera K, Sharma A, Baker JN, Johnson LM. Ethical issues in the care of adolescent and young adult oncology patients. Pediatr Blood Cancer. 2019 05; 66(5):e27608. PMID: 30623573.
    Citations:    Fields:    
  3. Levine DR, Johnson LM, Snyder A, Wiser RK, Gibson D, Kane JR, Baker JN. Integrating Palliative Care in Pediatric Oncology: Evidence for an Evolving Paradigm for Comprehensive Cancer Care. J Natl Compr Canc Netw. 2016 06; 14(6):741-8. PMID: 27283167.
    Citations: 3     Fields:    Translation:Humans
  4. Torous J, Baker JT. Why Psychiatry Needs Data Science and Data Science Needs Psychiatry: Connecting With Technology. JAMA Psychiatry. 2016 Jan; 73(1):3-4. PMID: 26676879.
    Citations: 9     Fields:    Translation:Humans
  5. Shinn AK, Bolton KW, Karmacharya R, Lewandowski KE, Yuksel C, Baker JT, Chouinard VA, Pingali SM, Bye H, Cederbaum K, Öngür D. McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis. Early Interv Psychiatry. 2017 02; 11(1):83-90. PMID: 26616380.
    Citations: 3     Fields:    Translation:Humans
  6. Wang D, Buckner RL, Fox MD, Holt DJ, Holmes AJ, Stoecklein S, Langs G, Pan R, Qian T, Li K, Baker JT, Stufflebeam SM, Wang K, Wang X, Hong B, Liu H. Parcellating cortical functional networks in individuals. Nat Neurosci. 2015 Dec; 18(12):1853-60. PMID: 26551545.
    Citations: 48     Fields:    Translation:Humans
  7. Shinn AK, Baker JT, Lewandowski KE, Öngür D, Cohen BM. Aberrant cerebellar connectivity in motor and association networks in schizophrenia. Front Hum Neurosci. 2015; 9:134. PMID: 25852520.
    Citations: 10     
  8. Brennan BP, Tkachenko O, Schwab ZJ, Juelich RJ, Ryan EM, Athey AJ, Pope HG, Jenike MA, Baker JT, Killgore WD, Hudson JI, Jensen JE, Rauch SL. An Examination of Rostral Anterior Cingulate Cortex Function and Neurochemistry in Obsessive-Compulsive Disorder. Neuropsychopharmacology. 2015 Jul; 40(8):1866-76. PMID: 25662837.
    Citations: 8     Fields:    Translation:Humans
  9. Satterthwaite TD, Baker JT. How can studies of resting-state functional connectivity help us understand psychosis as a disorder of brain development? Curr Opin Neurobiol. 2015 Feb; 30:85-91. PMID: 25464373.
    Citations: 15     Fields:    Translation:HumansAnimals
  10. Baker JT, Holmes AJ, Masters GA, Yeo BT, Krienen F, Buckner RL, Öngür D. Disruption of cortical association networks in schizophrenia and psychotic bipolar disorder. JAMA Psychiatry. 2014 Feb; 71(2):109-18. PMID: 24306091.
    Citations: 75     Fields:    Translation:Humans
  11. Shinn AK, Baker JT, Cohen BM, Ongür D. Functional connectivity of left Heschl's gyrus in vulnerability to auditory hallucinations in schizophrenia. Schizophr Res. 2013 Feb; 143(2-3):260-8. PMID: 23287311.
    Citations: 24     Fields:    Translation:Humans
  12. Yüksel C, McCarthy J, Shinn A, Pfaff DL, Baker JT, Heckers S, Renshaw P, Ongür D. Gray matter volume in schizophrenia and bipolar disorder with psychotic features. Schizophr Res. 2012 Jul; 138(2-3):177-82. PMID: 22445668.
    Citations: 5     Fields:    Translation:HumansCells
  13. Patel GH, Shulman GL, Baker JT, Akbudak E, Snyder AZ, Snyder LH, Corbetta M. Topographic organization of macaque area LIP. Proc Natl Acad Sci U S A. 2010 Mar 09; 107(10):4728-33. PMID: 20173093.
    Citations: 23     Fields:    Translation:HumansAnimals
  14. Vincent JL, Patel GH, Fox MD, Snyder AZ, Baker JT, Van Essen DC, Zempel JM, Snyder LH, Corbetta M, Raichle ME. Intrinsic functional architecture in the anaesthetized monkey brain. Nature. 2007 May 03; 447(7140):83-6. PMID: 17476267.
    Citations: 604     Fields:    Translation:HumansAnimals
  15. Baker JT, Patel GH, Corbetta M, Snyder LH. Distribution of activity across the monkey cerebral cortical surface, thalamus and midbrain during rapid, visually guided saccades. Cereb Cortex. 2006 Apr; 16(4):447-59. PMID: 15958778.
    Citations: 22     Fields:    Translation:Animals
  16. Baker JT, Harper TM, Snyder LH. Spatial memory following shifts of gaze. I. Saccades to memorized world-fixed and gaze-fixed targets. J Neurophysiol. 2003 May; 89(5):2564-76. PMID: 12740406.
    Citations: 17     Fields:    Translation:Animals
  17. Baker JT, Sanders AL, Maccotta L, Buckner RL. Neural correlates of verbal memory encoding during semantic and structural processing tasks. Neuroreport. 2001 May 08; 12(6):1251-6. PMID: 11338201.
    Citations: 25     Fields:    Translation:Humans
  18. Baker JT, Donoghue JP, Sanes JN. Gaze direction modulates finger movement activation patterns in human cerebral cortex. J Neurosci. 1999 Nov 15; 19(22):10044-52. PMID: 10559412.
    Citations: 21     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.