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Laurie Joy Goodyear, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AG055135 (GOODYEAR, LAURIE J) Dec 15, 2016 - Nov 30, 2022
    NIH/NIA
    Animal Studies Investigating Molecular Transducers of Physical Activity
    Role: Principal Investigator
  2. R01DK112283 (GOODYEAR, LAURIE J) Sep 16, 2016 - Jul 31, 2019
    NIH/NIDDK
    Exercise Regulation of Human Adipose Tissue
    Role: Principal Investigator
  3. R01DK099511 (GOODYEAR, LAURIE J) Apr 10, 2014 - Feb 28, 2019
    NIH/NIDDK
    Novel Mechanisms for Exercise Training Effects on Glucose Homeostasis
    Role: Principal Investigator
  4. R01DK101043 (GOODYEAR, LAURIE J) Sep 16, 2013 - Nov 30, 2022
    NIH/NIDDK
    Exercise regulation of glucose homeostasis
    Role: Principal Investigator
  5. R21DK091764 (GOODYEAR, LAURIE J) Apr 10, 2011 - Mar 31, 2013
    NIH/NIDDK
    Novel Mechanisms for Exercise Training Effects on Glucose Homeostasis
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Animal Physiology Core (JDC) - Core services (9) and Instruments (9)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lehnig AC, Dewal RS, Baer LA, Kitching KM, Munoz VR, Arts PJ, Sindeldecker DA, May FJ, Lauritzen HPMM, Goodyear LJ, Stanford KI. Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue. iScience. 2019 Jan 25; 11:425-439. PMID: 30661000.
    Citations:    
  2. Stanford KI, Rasmussen M, Baer LA, Lehnig AC, Rowland LA, White JD, So K, De Sousa-Coelho AL, Hirshman MF, Patti ME, Rando OJ, Goodyear LJ. Paternal Exercise Improves Glucose Metabolism in Adult Offspring. Diabetes. 2018 12; 67(12):2530-2540. PMID: 30344184.
    Citations:    Fields:    
  3. Sun XL, Lessard SJ, An D, Koh HJ, Esumi H, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart. J Cell Biochem. 2019 Jan; 120(1):685-696. PMID: 30256437.
    Citations:    Fields:    
  4. Wang H, Arias EB, Pataky MW, Goodyear LJ, Cartee GD. Postexercise improvement in glucose uptake occurs concomitant with greater ?3-AMPK activation and AS160 phosphorylation in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2018 Nov 01; 315(5):E859-E871. PMID: 30130149.
    Citations:    Fields:    
  5. Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab. 2018 Nov; 17:61-70. PMID: 30190193.
    Citations:    Fields:    
  6. Lessard SJ, MacDonald TL, Pathak P, Han MS, Coffey VG, Edge J, Rivas DA, Hirshman MF, Davis RJ, Goodyear LJ. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nat Commun. 2018 08 02; 9(1):3030. PMID: 30072727.
    Citations:    Fields:    Translation:HumansAnimalsCells
  7. Stanford KI, Goodyear LJ. Muscle-Adipose Tissue Cross Talk. Cold Spring Harb Perspect Med. 2018 08 01; 8(8). PMID: 28507197.
    Citations: 1     Fields:    
  8. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 Jun 05; 27(6):1357. PMID: 29874569.
    Citations:    Fields:    
  9. Mul JD, Soto M, Cahill ME, Ryan RE, Takahashi H, So K, Zheng J, Croote DE, Hirshman MF, la Fleur SE, Nestler EJ, Goodyear LJ. Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens ?FosB. Neuropsychopharmacology. 2018 08; 43(9):1934-1942. PMID: 29875450.
    Citations: 1     Fields:    
  10. Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake. Cell Metab. 2018 May 01; 27(5):1111-1120.e3. PMID: 29719226.
    Citations: 2     Fields:    
  11. Arbiv OA, Cuvelier G, Klaassen RJ, Fernandez CV, Robitaille N, Steele M, Breakey V, Abish S, Wu J, Sinha R, Silva M, Goodyear L, Jardine L, Lipton JH, Corriveau-Bourque C, Brossard J, Michon B, Ghemlas I, Waespe N, Zlateska B, Sung L, Cada M, Dror Y. Molecular analysis and genotype-phenotype correlation of Diamond-Blackfan anemia. Clin Genet. 2018 Feb; 93(2):320-328. PMID: 29044489.
    Citations: 1     Fields:    
  12. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 Nov 07; 23(11):1384. PMID: 29117173.
    Citations:    Fields:    
  13. Choi RH, McConahay A, Jeong HW, McClellan JL, Hardee JP, Carson JA, Hirshman MF, Goodyear LJ, Koh HJ. Tribbles 3 regulates protein turnover in mouse skeletal muscle. Biochem Biophys Res Commun. 2017 11 25; 493(3):1236-1242. PMID: 28962861.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Laker RC, Drake JC, Wilson RJ, Lira VA, Lewellen BM, Ryall KA, Fisher CC, Zhang M, Saucerman JJ, Goodyear LJ, Kundu M, Yan Z. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat Commun. 2017 09 15; 8(1):548. PMID: 28916822.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  15. Motiani P, Virtanen KA, Motiani KK, Eskelinen JJ, Middelbeek RJ, Goodyear LJ, Savolainen AM, Kemppainen J, Jensen J, Din MU, Saunavaara V, Parkkola R, Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men. Diabetes Obes Metab. 2017 10; 19(10):1379-1388. PMID: 28318098.
    Citations: 2     Fields:    Translation:Humans
  16. Stanford KI, Takahashi H, So K, Alves-Wagner AB, Prince NB, Lehnig AC, Getchell KM, Lee MY, Hirshman MF, Goodyear LJ. Maternal Exercise Improves Glucose Tolerance in Female Offspring. Diabetes. 2017 08; 66(8):2124-2136. PMID: 28572303.
    Citations: 2     Fields:    Translation:Animals
  17. Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med. 2017 May; 23(5):631-637. PMID: 28346411.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  18. May FJ, Baer LA, Lehnig AC, So K, Chen EY, Gao F, Narain NR, Gushchina L, Rose A, Doseff AI, Kiebish MA, Goodyear LJ, Stanford KI. Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling. Cell Rep. 2017 02 07; 18(6):1558-1572. PMID: 28178530.
    Citations: 4     Fields:    Translation:Animals
  19. Mul JD, Zheng J, Goodyear LJ. Validity Assessment of 5 Day Repeated Forced-Swim Stress to Model Human Depression in Young-Adult C57BL/6J and BALB/cJ Mice. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28058270.
    Citations: 4     Fields:    Translation:Animals
  20. O'Neill BT, Lee KY, Klaus K, Softic S, Krumpoch MT, Fentz J, Stanford KI, Robinson MM, Cai W, Kleinridders A, Pereira RO, Hirshman MF, Abel ED, Accili D, Goodyear LJ, Nair KS, Kahn CR. Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis. J Clin Invest. 2016 09 01; 126(9):3433-46. PMID: 27525440.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Lerin C, Goldfine AB, Boes T, Liu M, Kasif S, Dreyfuss JM, De Sousa-Coelho AL, Daher G, Manoli I, Sysol JR, Isganaitis E, Jessen N, Goodyear LJ, Beebe K, Gall W, Venditti CP, Patti ME. Defects in muscle branched-chain amino acid oxidation contribute to impaired lipid metabolism. Mol Metab. 2016 Oct; 5(10):926-936. PMID: 27689005.
    Citations: 15     Fields:    
  22. Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O'Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y, Tseng YH. Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance. Diabetologia. 2016 08; 59(8):1769-77. PMID: 27209464; PMCID: PMC4930470.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Stanford KI, Goodyear LJ. Exercise regulation of adipose tissue. Adipocyte. 2016 Apr-Jun; 5(2):153-62. PMID: 27386159.
    Citations: 9     Fields:    
  24. Lessard SJ, Rivas DA, So K, Koh HJ, Queiroz AL, Hirshman MF, Fielding RA, Goodyear LJ. The AMPK-related kinase SNARK regulates muscle mass and myocyte survival. J Clin Invest. 2016 Feb; 126(2):560-70. PMID: 26690705; PMCID: PMC4731174.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. Ernande L, Stanford KI, Thoonen R, Zhang H, Clerte M, Hirshman MF, Goodyear LJ, Bloch KD, Buys ES, Scherrer-Crosbie M. Relationship of brown adipose tissue perfusion and function: a study through ß2-adrenoreceptor stimulation. J Appl Physiol (1985). 2016 Apr 15; 120(8):825-32. PMID: 26823340; PMCID: PMC4835910.
    Citations: 1     Fields:    Translation:Animals
  26. Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun. 2016 Feb 19; 470(4):783-91. PMID: 26801556.
    Citations: 1     Fields:    Translation:AnimalsCells
  27. Yu H, Fujii NL, Toyoda T, An D, Farese RV, Leitges M, Hirshman MF, Mul JD, Goodyear LJ. Contraction stimulates muscle glucose uptake independent of atypical PKC. Physiol Rep. 2015 Nov; 3(11). PMID: 26564060.
    Citations: 1     Fields:    
  28. Stanford KI, Middelbeek RJ, Goodyear LJ. Erratum. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes 2015;64:2361-2368. Diabetes. 2015 Sep; 64(9):3334. PMID: 26294430; PMCID: PMC4877678.
    Citations: 1     Fields:    
  29. Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR. Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015 Aug 24; 6:8054. PMID: 26299309; PMCID: PMC4552045.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH. MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1a signaling network. EMBO Rep. 2015 Oct; 16(10):1378-93. PMID: 26303948; PMCID: PMC4766451.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  31. Mul JD, Stanford KI, Hirshman MF, Goodyear LJ. Exercise and Regulation of Carbohydrate Metabolism. Prog Mol Biol Transl Sci. 2015; 135:17-37. PMID: 26477909; PMCID: PMC4727532.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  32. Obici S, Magrisso IJ, Ghazarian AS, Shirazian A, Miller JR, Loyd CM, Begg DP, Krawczewski Carhuatanta KA, Haas MK, Davis JF, Woods SC, Sandoval DA, Seeley RJ, Goodyear LJ, Pothos EN, Mul JD. Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation. Mol Metab. 2015 Oct; 4(10):692-705. PMID: 26500841; PMCID: PMC4588435.
    Citations: 5     Fields:    
  33. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015 Jul; 21(7):760-8. PMID: 26076036; PMCID: PMC4496292.
    Citations: 42     Fields:    Translation:HumansCells
  34. Stanford KI, Middelbeek RJ, Goodyear LJ. Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations. Diabetes. 2015 Jul; 64(7):2361-8. PMID: 26050668; PMCID: PMC4477356.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  35. O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, Kahn CR. Differential Role of Insulin/IGF-1 Receptor Signaling in Muscle Growth and Glucose Homeostasis. Cell Rep. 2015 May 26; 11(8):1220-35. PMID: 25981038; PMCID: PMC4449334.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A novel role for subcutaneous adipose tissue in exercise-induced improvements in glucose homeostasis. Diabetes. 2015 Jun; 64(6):2002-14. PMID: 25605808; PMCID: PMC4439563.
    Citations: 45     Fields:    Translation:Animals
  37. Stanford KI, Goodyear LJ. Exercise and type 2 diabetes: molecular mechanisms regulating glucose uptake in skeletal muscle. Adv Physiol Educ. 2014 Dec; 38(4):308-14. PMID: 25434013; PMCID: PMC4315445.
    Citations: 18     Fields:    Translation:Humans
  38. Stanford KI, Lee MY, Getchell KM, So K, Hirshman MF, Goodyear LJ. Exercise before and during pregnancy prevents the deleterious effects of maternal high-fat feeding on metabolic health of male offspring. Diabetes. 2015 Feb; 64(2):427-33. PMID: 25204976; PMCID: PMC4303966.
    Citations: 16     Fields:    Translation:Animals
  39. Rivas DA, Lessard SJ, Rice NP, Lustgarten MS, So K, Goodyear LJ, Parnell LD, Fielding RA. Diminished skeletal muscle microRNA expression with aging is associated with attenuated muscle plasticity and inhibition of IGF-1 signaling. FASEB J. 2014 Sep; 28(9):4133-47. PMID: 24928197.
    Citations: 29     Fields:    Translation:HumansCells
  40. Vendelbo MH, Møller AB, Treebak JT, Gormsen LC, Goodyear LJ, Wojtaszewski JF, Jørgensen JO, Møller N, Jessen N. Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise. J Appl Physiol (1985). 2014 Aug 01; 117(3):289-96. PMID: 24876356; PMCID: PMC4971896.
    Citations: 8     Fields:    Translation:HumansCells
  41. Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, Miller C, Regalado SG, Loffredo FS, Pancoast JR, Hirshman MF, Lebowitz J, Shadrach JL, Cerletti M, Kim MJ, Serwold T, Goodyear LJ, Rosner B, Lee RT, Wagers AJ. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science. 2014 May 09; 344(6184):649-52. PMID: 24797481; PMCID: PMC4104429.
    Citations: 181     Fields:    Translation:AnimalsCells
  42. An D, Lessard SJ, Toyoda T, Lee MY, Koh HJ, Qi L, Hirshman MF, Goodyear LJ. Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice. Am J Physiol Regul Integr Comp Physiol. 2014 Jun 15; 306(12):R925-33. PMID: 24740654; PMCID: PMC4159733.
    Citations: 5     Fields:    Translation:AnimalsCells
  43. Kristensen JM, Treebak JT, Schjerling P, Goodyear L, Wojtaszewski JF. Two weeks of metformin treatment induces AMPK-dependent enhancement of insulin-stimulated glucose uptake in mouse soleus muscle. Am J Physiol Endocrinol Metab. 2014 May 15; 306(10):E1099-109. PMID: 24644243; PMCID: PMC4971810.
    Citations: 7     Fields:    Translation:Animals
  44. Treebak JT, Pehmøller C, Kristensen JM, Kjøbsted R, Birk JB, Schjerling P, Richter EA, Goodyear LJ, Wojtaszewski JF. Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle. J Physiol. 2014 Jan 15; 592(2):351-75. PMID: 24247980; PMCID: PMC3922499.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  45. Stanford KI, Goodyear LJ. The therapeutic potential of brown adipose tissue. Hepatobiliary Surg Nutr. 2013 Oct; 2(5):286-7. PMID: 24570961; PMCID: PMC3924699.
    Citations: 2     
  46. Brandauer J, Vienberg SG, Andersen MA, Ringholm S, Risis S, Larsen PS, Kristensen JM, Frøsig C, Leick L, Fentz J, Jørgensen S, Kiens B, Wojtaszewski JF, Richter EA, Zierath JR, Goodyear LJ, Pilegaard H, Treebak JT. AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol. 2013 Oct 15; 591(20):5207-20. PMID: 23918774; PMCID: PMC3810819.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  47. Olesen J, Ringholm S, Nielsen MM, Brandt CT, Pedersen JT, Halling JF, Goodyear LJ, Pilegaard H. Role of PGC-1a in exercise training- and resveratrol-induced prevention of age-associated inflammation. Exp Gerontol. 2013 Nov; 48(11):1274-84. PMID: 23916840; PMCID: PMC4045249.
    Citations: 8     Fields:    Translation:AnimalsCells
  48. Lauritzen HP, Brandauer J, Schjerling P, Koh HJ, Treebak JT, Hirshman MF, Galbo H, Goodyear LJ. Contraction and AICAR stimulate IL-6 vesicle depletion from skeletal muscle fibers in vivo. Diabetes. 2013 Sep; 62(9):3081-92. PMID: 23761105; PMCID: PMC3749330.
    Citations: 11     Fields:    Translation:AnimalsCells
  49. Middelbeek RJ, Chambers MA, Tantiwong P, Treebak JT, An D, Hirshman MF, Musi N, Goodyear LJ. Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle. Nutr Diabetes. 2013 Jun 10; 3:e74. PMID: 23752133; PMCID: PMC3697402.
    Citations: 7     Fields:    
  50. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Rep. 2013 May 30; 3(5):1449-56. PMID: 23707060; PMCID: PMC3688451.
    Citations: 38     Fields:    Translation:AnimalsCells
  51. Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG, Goodyear LJ. Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes. 2013 Aug; 62(8):2717-27. PMID: 23610057; PMCID: PMC3717870.
    Citations: 16     Fields:    Translation:AnimalsCells
  52. Friedrichsen M, Birk JB, Richter EA, Ribel-Madsen R, Pehmøller C, Hansen BF, Beck-Nielsen H, Hirshman MF, Goodyear LJ, Vaag A, Poulsen P, Wojtaszewski JF. Akt2 influences glycogen synthase activity in human skeletal muscle through regulation of NH2-terminal (sites 2 + 2a) phosphorylation. Am J Physiol Endocrinol Metab. 2013 Mar 15; 304(6):E631-9. PMID: 23321478; PMCID: PMC3774094.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  53. Manabe Y, Gollisch KS, Holton L, Kim YB, Brandauer J, Fujii NL, Hirshman MF, Goodyear LJ. Exercise training-induced adaptations associated with increases in skeletal muscle glycogen content. FEBS J. 2013 Feb; 280(3):916-26. PMID: 23206309; PMCID: PMC3558638.
    Citations: 10     Fields:    Translation:Animals
  54. Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med. 2013 Feb; 19(2):217-26. PMID: 23291629; PMCID: PMC3567215.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  55. Koh HJ, Toyoda T, Didesch MM, Lee MY, Sleeman MW, Kulkarni RN, Musi N, Hirshman MF, Goodyear LJ. Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle. Nat Commun. 2013; 4:1871. PMID: 23695665; PMCID: PMC3707125.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  56. Manabe Y, Miyatake S, Takagi M, Nakamura M, Okeda A, Nakano T, Hirshman MF, Goodyear LJ, Fujii NL. Characterization of an acute muscle contraction model using cultured C2C12 myotubes. PLoS One. 2012; 7(12):e52592. PMID: 23300713; PMCID: PMC3534077.
    Citations: 24     Fields:    Translation:AnimalsCells
  57. Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013 Jan; 123(1):215-23. PMID: 23221344; PMCID: PMC3533266.
    Citations: 214     Fields:    Translation:Animals
  58. Townsend KL, An D, Lynes MD, Huang TL, Zhang H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antioxid Redox Signal. 2013 Jul 20; 19(3):243-57. PMID: 22938691; PMCID: PMC3691916.
    Citations: 21     Fields:    Translation:AnimalsCells
  59. Pehmøller C, Brandt N, Birk JB, Høeg LD, Sjøberg KA, Goodyear LJ, Kiens B, Richter EA, Wojtaszewski JF. Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4. Diabetes. 2012 Nov; 61(11):2743-52. PMID: 22851577; PMCID: PMC3478539.
    Citations: 24     Fields:    Translation:HumansCells
  60. Henstridge DC, Bruce CR, Pang CP, Lancaster GI, Allen TL, Estevez E, Gardner T, Weir JM, Meikle PJ, Lam KSL, Xu A, Fujii N, Goodyear LJ, Febbraio MA. Skeletal muscle-specific overproduction of constitutively activated c-Jun N-terminal kinase (JNK) induces insulin resistance in mice. Diabetologia. 2012 Oct; 55(10):2769-2778. PMID: 22832498; PMCID: PMC3590919.
    Citations: 16     Fields:    Translation:AnimalsCells
  61. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Jan 08; 18(2):244-51. PMID: 22231556; PMCID: PMC3274651.
    Citations: 32     Fields:    Translation:AnimalsCells
  62. Vendelbo MH, Clasen BF, Treebak JT, Møller L, Krusenstjerna-Hafstrøm T, Madsen M, Nielsen TS, Stødkilde-Jørgensen H, Pedersen SB, Jørgensen JO, Goodyear LJ, Wojtaszewski JF, Møller N, Jessen N. Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle. Am J Physiol Endocrinol Metab. 2012 Jan 15; 302(2):E190-200. PMID: 22028408; PMCID: PMC4971894.
    Citations: 17     Fields:    Translation:HumansCells
  63. Jessen N, An D, Lihn AS, Nygren J, Hirshman MF, Thorell A, Goodyear LJ. Exercise increases TBC1D1 phosphorylation in human skeletal muscle. Am J Physiol Endocrinol Metab. 2011 Jul; 301(1):E164-71. PMID: 21505148; PMCID: PMC3129834.
    Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
  64. Toyoda T, An D, Witczak CA, Koh HJ, Hirshman MF, Fujii N, Goodyear LJ. Myo1c regulates glucose uptake in mouse skeletal muscle. J Biol Chem. 2011 Feb 11; 286(6):4133-40. PMID: 21127070; PMCID: PMC3039380.
    Citations: 16     Fields:    Translation:AnimalsCells
  65. Vichaiwong K, Purohit S, An D, Toyoda T, Jessen N, Hirshman MF, Goodyear LJ. Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle. Biochem J. 2010 Oct 15; 431(2):311-20. PMID: 20701589; PMCID: PMC2947193.
    Citations: 26     Fields:    Translation:AnimalsCells
  66. Koh HJ, Toyoda T, Fujii N, Jung MM, Rathod A, Middelbeek RJ, Lessard SJ, Treebak JT, Tsuchihara K, Esumi H, Richter EA, Wojtaszewski JF, Hirshman MF, Goodyear LJ. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15541-6. PMID: 20713714; PMCID: PMC2932588.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  67. Lauritzen HP, Galbo H, Toyoda T, Goodyear LJ. Kinetics of contraction-induced GLUT4 translocation in skeletal muscle fibers from living mice. Diabetes. 2010 Sep; 59(9):2134-44. PMID: 20622170; PMCID: PMC2927934.
    Citations: 29     Fields:    Translation:AnimalsCells
  68. Jessen N, Goodyear LJ. Diabetes: Exercise and type 2 diabetes mellitus--good for body and mind? Nat Rev Endocrinol. 2010 Jun; 6(6):303-4. PMID: 20502463.
    Citations: 2     Fields:    Translation:Humans
  69. Jessen N, Koh HJ, Folmes CD, Wagg C, Fujii N, Løfgren B, Wolf CM, Berul CI, Hirshman MF, Lopaschuk GD, Goodyear LJ. Ablation of LKB1 in the heart leads to energy deprivation and impaired cardiac function. Biochim Biophys Acta. 2010 Jul-Aug; 1802(7-8):593-600. PMID: 20441792; PMCID: PMC2893233.
    Citations: 17     Fields:    Translation:AnimalsCells
  70. An D, Toyoda T, Taylor EB, Yu H, Fujii N, Hirshman MF, Goodyear LJ. TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle. Diabetes. 2010 Jun; 59(6):1358-65. PMID: 20299473; PMCID: PMC2874696.
    Citations: 49     Fields:    Translation:AnimalsCells
  71. Witczak CA, Jessen N, Warro DM, Toyoda T, Fujii N, Anderson ME, Hirshman MF, Goodyear LJ. CaMKII regulates contraction- but not insulin-induced glucose uptake in mouse skeletal muscle. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1150-60. PMID: 20215576; PMCID: PMC2886528.
    Citations: 25     Fields:    Translation:Animals
  72. Sharoff CG, Hagobian TA, Malin SK, Chipkin SR, Yu H, Hirshman MF, Goodyear LJ, Braun B. Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals. Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E815-23. PMID: 20071560; PMCID: PMC3774338.
    Citations: 27     Fields:    Translation:HumansCells
  73. Treebak JT, Taylor EB, Witczak CA, An D, Toyoda T, Koh HJ, Xie J, Feener EP, Wojtaszewski JF, Hirshman MF, Goodyear LJ. Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. Am J Physiol Cell Physiol. 2010 Feb; 298(2):C377-85. PMID: 19923418; PMCID: PMC2822490.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  74. Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL, Goodyear LJ, Tong Q. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY). 2009 Aug 15; 1(9):771-83. PMID: 20157566; PMCID: PMC2815736.
    Citations: 142     Fields:    Translation:AnimalsCells
  75. Gollisch KS, Brandauer J, Jessen N, Toyoda T, Nayer A, Hirshman MF, Goodyear LJ. Effects of exercise training on subcutaneous and visceral adipose tissue in normal- and high-fat diet-fed rats. Am J Physiol Endocrinol Metab. 2009 Aug; 297(2):E495-504. PMID: 19491293; PMCID: PMC2724117.
    Citations: 55     Fields:    Translation:Animals
  76. Chambers MA, Moylan JS, Smith JD, Goodyear LJ, Reid MB. Stretch-stimulated glucose uptake in skeletal muscle is mediated by reactive oxygen species and p38 MAP-kinase. J Physiol. 2009 Jul 01; 587(Pt 13):3363-73. PMID: 19403598; PMCID: PMC2727043.
    Citations: 40     Fields:    Translation:AnimalsCells
  77. Rogers NH, Witczak CA, Hirshman MF, Goodyear LJ, Greenberg AS. Estradiol stimulates Akt, AMP-activated protein kinase (AMPK) and TBC1D1/4, but not glucose uptake in rat soleus. Biochem Biophys Res Commun. 2009 May 15; 382(4):646-50. PMID: 19265681; PMCID: PMC2692044.
    Citations: 35     Fields:    Translation:Animals
  78. Witczak CA, Sharoff CG, Goodyear LJ. AMP-activated protein kinase in skeletal muscle: from structure and localization to its role as a master regulator of cellular metabolism. Cell Mol Life Sci. 2008 Nov; 65(23):3737-55. PMID: 18810325.
    Citations: 73     Fields:    
  79. Goodyear LJ. The exercise pill--too good to be true? N Engl J Med. 2008 Oct 23; 359(17):1842-4. PMID: 18946072.
    Citations: 29     Fields:    Translation:HumansAnimals
  80. Fujii N, Ho RC, Manabe Y, Jessen N, Toyoda T, Holland WL, Summers SA, Hirshman MF, Goodyear LJ. Ablation of AMP-activated protein kinase alpha2 activity exacerbates insulin resistance induced by high-fat feeding of mice. Diabetes. 2008 Nov; 57(11):2958-66. PMID: 18728234; PMCID: PMC2570392.
    Citations: 39     Fields:    Translation:Animals
  81. Norris AW, Hirshman MF, Yao J, Jessen N, Musi N, Chen L, Sivitz WI, Goodyear LJ, Kahn CR. Endogenous peroxisome proliferator-activated receptor-gamma augments fatty acid uptake in oxidative muscle. Endocrinology. 2008 Nov; 149(11):5374-83. PMID: 18653710; PMCID: PMC2584586.
    Citations: 5     Fields:    Translation:AnimalsCells
  82. Cerletti M, Jurga S, Witczak CA, Hirshman MF, Shadrach JL, Goodyear LJ, Wagers AJ. Highly efficient, functional engraftment of skeletal muscle stem cells in dystrophic muscles. Cell. 2008 Jul 11; 134(1):37-47. PMID: 18614009; PMCID: PMC3665268.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  83. Koh HJ, Brandauer J, Goodyear LJ. LKB1 and AMPK and the regulation of skeletal muscle metabolism. Curr Opin Clin Nutr Metab Care. 2008 May; 11(3):227-32. PMID: 18403917; PMCID: PMC2887290.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  84. Röckl KS, Witczak CA, Goodyear LJ. Signaling mechanisms in skeletal muscle: acute responses and chronic adaptations to exercise. IUBMB Life. 2008 Mar; 60(3):145-53. PMID: 18380005; PMCID: PMC2885767.
    Citations: 60     Fields:    Translation:HumansCells
  85. Higaki Y, Mikami T, Fujii N, Hirshman MF, Koyama K, Seino T, Tanaka K, Goodyear LJ. Oxidative stress stimulates skeletal muscle glucose uptake through a phosphatidylinositol 3-kinase-dependent pathway. Am J Physiol Endocrinol Metab. 2008 May; 294(5):E889-97. PMID: 18303121; PMCID: PMC2882683.
    Citations: 33     Fields:    Translation:AnimalsCells
  86. Taylor EB, An D, Kramer HF, Yu H, Fujii NL, Roeckl KS, Bowles N, Hirshman MF, Xie J, Feener EP, Goodyear LJ. Discovery of TBC1D1 as an insulin-, AICAR-, and contraction-stimulated signaling nexus in mouse skeletal muscle. J Biol Chem. 2008 Apr 11; 283(15):9787-96. PMID: 18276596; PMCID: PMC2442306.
    Citations: 80     Fields:    Translation:AnimalsCells
  87. Taylor EB, Goodyear LJ. Targeting skeletal muscle AMP-activated protein kinase to treat type 2 diabetes. Curr Diab Rep. 2007 Dec; 7(6):399-401. PMID: 18254999.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  88. Bouskila M, Hirshman MF, Jensen J, Goodyear LJ, Sakamoto K. Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle. Am J Physiol Endocrinol Metab. 2008 Jan; 294(1):E28-35. PMID: 18003720.
    Citations: 26     Fields:    Translation:AnimalsCells
  89. Lauritzen HP, Galbo H, Brandauer J, Goodyear LJ, Ploug T. Large GLUT4 vesicles are stationary while locally and reversibly depleted during transient insulin stimulation of skeletal muscle of living mice: imaging analysis of GLUT4-enhanced green fluorescent protein vesicle dynamics. Diabetes. 2008 Feb; 57(2):315-24. PMID: 17977960.
    Citations: 24     Fields:    Translation:AnimalsCells
  90. Kramer HF, Taylor EB, Witczak CA, Fujii N, Hirshman MF, Goodyear LJ. Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle. Diabetes. 2007 Dec; 56(12):2854-62. PMID: 17717281.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Ho RC, Fujii N, Witters LA, Hirshman MF, Goodyear LJ. Dissociation of AMP-activated protein kinase and p38 mitogen-activated protein kinase signaling in skeletal muscle. Biochem Biophys Res Commun. 2007 Oct 19; 362(2):354-9. PMID: 17709097; PMCID: PMC2040310.
    Citations: 7     Fields:    Translation:AnimalsCells
  92. Röckl KS, Hirshman MF, Brandauer J, Fujii N, Witters LA, Goodyear LJ. Skeletal muscle adaptation to exercise training: AMP-activated protein kinase mediates muscle fiber type shift. Diabetes. 2007 Aug; 56(8):2062-9. PMID: 17513699.
    Citations: 85     Fields:    Translation:Animals
  93. Koh HJ, Hirshman MF, He H, Li Y, Manabe Y, Balschi JA, Goodyear LJ. Adrenaline is a critical mediator of acute exercise-induced AMP-activated protein kinase activation in adipocytes. Biochem J. 2007 May 01; 403(3):473-81. PMID: 17253964; PMCID: PMC1876380.
    Citations: 39     Fields:    Translation:AnimalsCells
  94. Fujii N, Seifert MM, Kane EM, Peter LE, Ho RC, Winstead S, Hirshman MF, Goodyear LJ. Role of AMP-activated protein kinase in exercise capacity, whole body glucose homeostasis, and glucose transport in skeletal muscle -insight from analysis of a transgenic mouse model-. Diabetes Res Clin Pract. 2007 Sep; 77 Suppl 1:S92-8. PMID: 17452058.
    Citations: 21     Fields:    Translation:Animals
  95. Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R. Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest. 2007 May; 117(5):1432-9. PMID: 17431505; PMCID: PMC1847536.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  96. Kramer HF, Goodyear LJ. Exercise, MAPK, and NF-kappaB signaling in skeletal muscle. J Appl Physiol (1985). 2007 Jul; 103(1):388-95. PMID: 17303713.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  97. Witczak CA, Fujii N, Hirshman MF, Goodyear LJ. Ca2+/calmodulin-dependent protein kinase kinase-alpha regulates skeletal muscle glucose uptake independent of AMP-activated protein kinase and Akt activation. Diabetes. 2007 May; 56(5):1403-9. PMID: 17287469.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  98. Barré L, Richardson C, Hirshman MF, Brozinick J, Fiering S, Kemp BE, Goodyear LJ, Witters LA. Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation. Am J Physiol Endocrinol Metab. 2007 Mar; 292(3):E802-11. PMID: 17106064.
    Citations: 20     Fields:    Translation:Animals
  99. Witczak CA, Hirshman MF, Jessen N, Fujii N, Seifert MM, Brandauer J, Hotamisligil GS, Goodyear LJ. JNK1 deficiency does not enhance muscle glucose metabolism in lean mice. Biochem Biophys Res Commun. 2006 Dec 01; 350(4):1063-8. PMID: 17045576; PMCID: PMC1929018.
    Citations: 6     Fields:    Translation:Animals
  100. Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 2006 Nov; 26(22):8217-27. PMID: 16966378; PMCID: PMC1636784.
    Citations: 85     Fields:    Translation:AnimalsCells
  101. Kramer HF, Witczak CA, Taylor EB, Fujii N, Hirshman MF, Goodyear LJ. AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle. J Biol Chem. 2006 Oct 20; 281(42):31478-85. PMID: 16935857.
    Citations: 88     Fields:    Translation:AnimalsCells
  102. Howlett KF, Sakamoto K, Yu H, Goodyear LJ, Hargreaves M. Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise. Metabolism. 2006 Aug; 55(8):1046-52. PMID: 16839840.
    Citations: 13     Fields:    Translation:HumansCells
  103. Fujii N, Jessen N, Goodyear LJ. AMP-activated protein kinase and the regulation of glucose transport. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E867-77. PMID: 16822958.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  104. Kramer HF, Witczak CA, Fujii N, Jessen N, Taylor EB, Arnolds DE, Sakamoto K, Hirshman MF, Goodyear LJ. Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle. Diabetes. 2006 Jul; 55(7):2067-76. PMID: 16804077.
    Citations: 95     Fields:    Translation:AnimalsCells
  105. Sakamoto K, Arnolds DE, Fujii N, Kramer HF, Hirshman MF, Goodyear LJ. Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1031-7. PMID: 16803855.
    Citations: 20     Fields:    Translation:AnimalsCells
  106. Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metab. 2006 May; 3(5):355-66. PMID: 16679293.
    Citations: 28     Fields:    Translation:AnimalsCells
  107. Yu H, Hirshman MF, Fujii N, Pomerleau JM, Peter LE, Goodyear LJ. Muscle-specific overexpression of wild type and R225Q mutant AMP-activated protein kinase gamma3-subunit differentially regulates glycogen accumulation. Am J Physiol Endocrinol Metab. 2006 Sep; 291(3):E557-65. PMID: 16638825.
    Citations: 10     Fields:    Translation:Animals
  108. Aschenbach WG, Ho RC, Sakamoto K, Fujii N, Li Y, Kim YB, Hirshman MF, Goodyear LJ. Regulation of dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E152-8. PMID: 16478782.
    Citations: 17     Fields:    Translation:AnimalsCells
  109. Musi N, Goodyear LJ. Insulin resistance and improvements in signal transduction. Endocrine. 2006 Feb; 29(1):73-80. PMID: 16622294.
    Citations: 20     Fields:    Translation:HumansCells
  110. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303. PMID: 16434556.
    Citations: 16     Fields:    Translation:HumansCellsCTClinical Trials
  111. Ahmad F, Arad M, Musi N, He H, Wolf C, Branco D, Perez-Atayde AR, Stapleton D, Bali D, Xing Y, Tian R, Goodyear LJ, Berul CI, Ingwall JS, Seidman CE, Seidman JG. Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. Circulation. 2005 Nov 15; 112(20):3140-8. PMID: 16275868.
    Citations: 29     Fields:    Translation:HumansAnimals
  112. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov; 25(21):9713-23. PMID: 16227617; PMCID: PMC1265843.
    Citations: 14     Fields:    Translation:AnimalsCells
  113. Fujii N, Hirshman MF, Kane EM, Ho RC, Peter LE, Seifert MM, Goodyear LJ. AMP-activated protein kinase alpha2 activity is not essential for contraction- and hyperosmolarity-induced glucose transport in skeletal muscle. J Biol Chem. 2005 Nov 25; 280(47):39033-41. PMID: 16186119.
    Citations: 67     Fields:    Translation:AnimalsCells
  114. Jessen N, Goodyear LJ. Contraction signaling to glucose transport in skeletal muscle. J Appl Physiol (1985). 2005 Jul; 99(1):330-7. PMID: 16036906.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  115. Ho RC, Hirshman MF, Li Y, Cai D, Farmer JR, Aschenbach WG, Witczak CA, Shoelson SE, Goodyear LJ. Regulation of IkappaB kinase and NF-kappaB in contracting adult rat skeletal muscle. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C794-801. PMID: 15888549.
    Citations: 31     Fields:    Translation:AnimalsCells
  116. Musi N, Hirshman MF, Arad M, Xing Y, Fujii N, Pomerleau J, Ahmad F, Berul CI, Seidman JG, Tian R, Goodyear LJ. Functional role of AMP-activated protein kinase in the heart during exercise. FEBS Lett. 2005 Apr 11; 579(10):2045-50. PMID: 15811316.
    Citations: 19     Fields:    Translation:AnimalsCells
  117. Pold R, Jensen LS, Jessen N, Buhl ES, Schmitz O, Flyvbjerg A, Fujii N, Goodyear LJ, Gotfredsen CF, Brand CL, Lund S. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes. 2005 Apr; 54(4):928-34. PMID: 15793229.
    Citations: 65     Fields:    Translation:AnimalsCells
  118. Jimenez-Chillaron JC, Hernandez-Valencia M, Reamer C, Fisher S, Joszi A, Hirshman M, Oge A, Walrond S, Przybyla R, Boozer C, Goodyear LJ, Patti ME. Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Diabetes. 2005 Mar; 54(3):702-11. PMID: 15734846.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  119. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
    Citations: 2     Fields:    
  120. Sakamoto K, Arnolds DE, Ekberg I, Thorell A, Goodyear LJ. Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle. Biochem Biophys Res Commun. 2004 Jun 25; 319(2):419-25. PMID: 15178423.
    Citations: 23     Fields:    Translation:HumansCells
  121. Fujii N, Aschenbach WG, Musi N, Hirshman MF, Goodyear LJ. Regulation of glucose transport by the AMP-activated protein kinase. Proc Nutr Soc. 2004 May; 63(2):205-10. PMID: 15294031.
    Citations: 9     Fields:    Translation:HumansCells
  122. Alcazar O, Ho RC, Fujii N, Goodyear LJ. cDNA cloning and functional characterization of a novel splice variant of c-Cbl-associated protein from mouse skeletal muscle. Biochem Biophys Res Commun. 2004 Apr 23; 317(1):285-93. PMID: 15047181.
    Citations: 4     Fields:    Translation:AnimalsCells
  123. Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol. 2004 Jul; 287(1):C200-8. PMID: 15013949.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  124. Omer A, Duvivier-Kali VF, Aschenbach W, Tchipashvili V, Goodyear LJ, Weir GC. Exercise induces hypoglycemia in rats with islet transplantation. Diabetes. 2004 Feb; 53(2):360-5. PMID: 14747286.
    Citations: 8     Fields:    Translation:Animals
  125. Aschenbach WG, Sakamoto K, Goodyear LJ. 5' adenosine monophosphate-activated protein kinase, metabolism and exercise. Sports Med. 2004; 34(2):91-103. PMID: 14965188.
    Citations: 10     Fields:    Translation:HumansCells
  126. Chen D, Mauvais-Jarvis F, Bluher M, Fisher SJ, Jozsi A, Goodyear LJ, Ueki K, Kahn CR. p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. Mol Cell Biol. 2004 Jan; 24(1):320-9. PMID: 14673165; PMCID: PMC303335.
    Citations: 29     Fields:    Translation:Animals
  127. Ho RC, Alcazar O, Fujii N, Hirshman MF, Goodyear LJ. p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R342-9. PMID: 14592936.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  128. Yu H, Fujii N, Hirshman MF, Pomerleau JM, Goodyear LJ. Cloning and characterization of mouse 5'-AMP-activated protein kinase gamma3 subunit. Am J Physiol Cell Physiol. 2004 Feb; 286(2):C283-92. PMID: 14512293.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  129. Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J Clin Invest. 2003 Aug; 112(4):608-18. PMID: 12925701; PMCID: PMC171387.
    Citations: 129     Fields:    Translation:Animals
  130. Musi N, Goodyear LJ. AMP-activated protein kinase and muscle glucose uptake. Acta Physiol Scand. 2003 Aug; 178(4):337-45. PMID: 12864738.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  131. Sakamoto K, Aschenbach WG, Hirshman MF, Goodyear LJ. Akt signaling in skeletal muscle: regulation by exercise and passive stretch. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1081-8. PMID: 12837666.
    Citations: 41     Fields:    Translation:AnimalsCells
  132. El-Haschimi K, Dufresne SD, Hirshman MF, Flier JS, Goodyear LJ, Bjørbaek C. Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes. 2003 Jun; 52(6):1340-6. PMID: 12765942.
    Citations: 10     Fields:    Translation:AnimalsCells
  133. Xing Y, Musi N, Fujii N, Zou L, Luptak I, Hirshman MF, Goodyear LJ, Tian R. Glucose metabolism and energy homeostasis in mouse hearts overexpressing dominant negative alpha2 subunit of AMP-activated protein kinase. J Biol Chem. 2003 Aug 01; 278(31):28372-7. PMID: 12766162.
    Citations: 68     Fields:    Translation:AnimalsCells
  134. Musi N, Yu H, Goodyear LJ. AMP-activated protein kinase regulation and action in skeletal muscle during exercise. Biochem Soc Trans. 2003 Feb; 31(Pt 1):191-5. PMID: 12546683.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  135. Nielsen JN, Mustard KJ, Graham DA, Yu H, MacDonald CS, Pilegaard H, Goodyear LJ, Hardie DG, Richter EA, Wojtaszewski JF. 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J Appl Physiol (1985). 2003 Feb; 94(2):631-41. PMID: 12391032.
    Citations: 41     Fields:    Translation:HumansCells
  136. Stoppani J, Hildebrandt AL, Sakamoto K, Cameron-Smith D, Goodyear LJ, Neufer PD. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2002 Dec; 283(6):E1239-48. PMID: 12388122.
    Citations: 26     Fields:    Translation:AnimalsCells
  137. Musi N, Goodyear LJ. Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes. Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul; 2(2):119-27. PMID: 12476786.
    Citations: 19     Fields:    Translation:HumansAnimals
  138. Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ. Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes. 2002 Jul; 51(7):2074-81. PMID: 12086935.
    Citations: 160     Fields:    Translation:HumansCTClinical Trials
  139. Sakamoto K, Goodyear LJ. Invited review: intracellular signaling in contracting skeletal muscle. J Appl Physiol (1985). 2002 Jul; 93(1):369-83. PMID: 12070227.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  140. Aschenbach WG, Hirshman MF, Fujii N, Sakamoto K, Howlett KF, Goodyear LJ. Effect of AICAR treatment on glycogen metabolism in skeletal muscle. Diabetes. 2002 Mar; 51(3):567-73. PMID: 11872652.
    Citations: 23     Fields:    Translation:AnimalsCells
  141. Howlett KF, Sakamoto K, Hirshman MF, Aschenbach WG, Dow M, White MF, Goodyear LJ. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice. Diabetes. 2002 Feb; 51(2):479-83. PMID: 11812758.
    Citations: 15     Fields:    Translation:AnimalsCells
  142. Sakamoto K, Hirshman MF, Aschenbach WG, Goodyear LJ. Contraction regulation of Akt in rat skeletal muscle. J Biol Chem. 2002 Apr 05; 277(14):11910-7. PMID: 11809761.
    Citations: 49     Fields:    Translation:AnimalsCells
  143. Mauvais-Jarvis F, Ueki K, Fruman DA, Hirshman MF, Sakamoto K, Goodyear LJ, Iannacone M, Accili D, Cantley LC, Kahn CR. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. J Clin Invest. 2002 Jan; 109(1):141-9. PMID: 11781359; PMCID: PMC150818.
    Citations: 75     Fields:    Translation:AnimalsCells
  144. Habinowski SA, Hirshman M, Sakamoto K, Kemp BE, Gould SJ, Goodyear LJ, Witters LA. Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line. Arch Biochem Biophys. 2001 Dec 01; 396(1):71-9. PMID: 11716464.
    Citations: 9     Fields:    Translation:AnimalsCells
  145. Hamdy O, Goodyear LJ, Horton ES. Diet and exercise in type 2 diabetes mellitus. Endocrinol Metab Clin North Am. 2001 Dec; 30(4):883-907. PMID: 11727404.
    Citations: 17     Fields:    Translation:Humans
  146. Tian R, Musi N, D'Agostino J, Hirshman MF, Goodyear LJ. Increased adenosine monophosphate-activated protein kinase activity in rat hearts with pressure-overload hypertrophy. Circulation. 2001 Oct 02; 104(14):1664-9. PMID: 11581146.
    Citations: 79     Fields:    Translation:AnimalsCells
  147. Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct; 108(8):1167-74. PMID: 11602624; PMCID: PMC209533.
    Citations: 1309     Fields:    Translation:HumansAnimalsCells
  148. Aschenbach WG, Suzuki Y, Breeden K, Prats C, Hirshman MF, Dufresne SD, Sakamoto K, Vilardo PG, Steele M, Kim JH, Jing SL, Goodyear LJ, DePaoli-Roach AA. The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise. J Biol Chem. 2001 Oct 26; 276(43):39959-67. PMID: 11522787.
    Citations: 30     Fields:    Translation:AnimalsCells
  149. Musi N, Fujii N, Hirshman MF, Ekberg I, Fröberg S, Ljungqvist O, Thorell A, Goodyear LJ. AMP-activated protein kinase (AMPK) is activated in muscle of subjects with type 2 diabetes during exercise. Diabetes. 2001 May; 50(5):921-7. PMID: