Harvard Catalyst Profiles

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Tayyaba Hasan, Ph.D.

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Department
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Other Positions
Title
Institution
Department

Mentoring
Improving photodynamic therapy response in a subcutaneous glioblastoma model
Summer, 02/01/13 - 12/31/13
Combination-Based Photodynamic Therapy to Disrupt Compensatory VEGF Signalling in Pancreatic Cancer
Summer, 06/01/09 - 08/28/09

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54EB015408 (PARRISH, JOHN A) May 21, 2020 - May 31, 2023
    NIH/NIBIB
    Point of Care Technology Research Center in Primary Care
    Role: Co-Principal Investigator
  2. R13CA239610 (HASAN, TAYYABA) Apr 22, 2019 - Mar 31, 2020
    NIH/NCI
    17th Biennial International Photodynamic Association World Congress
    Role: Principal Investigator
  3. R01CA231606 (HASAN, TAYYABA) Apr 1, 2019 - Mar 31, 2024
    NIH/NCI
    Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapy
    Role: Principal Investigator
  4. R21CA220143 (HASAN, TAYYABA) Aug 1, 2017 - Jul 31, 2020
    NIH/NCI
    Optical imaging guided resection and photodynamic therapy of glioma with targeted photoactivable agents
    Role: Principal Investigator
  5. R21TW010202 (HASAN, TAYYABA) Sep 17, 2016 - Aug 31, 2018
    NIH/FIC
    Rapid treatment guidance for antibiotic-resistant disease at the point of care
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Broekgaarden M, Alkhateeb A, Bano S, Bulin AL, Obaid G, Rizvi I, Hasan T. Cabozantinib Inhibits Photodynamic Therapy-Induced Auto- and Paracrine MET Signaling in Heterotypic Pancreatic Microtumors. Cancers (Basel). 2020 May 29; 12(6). PMID: 32485915.
    Citations:    
  2. Hasan T, Kessel D, Greer A. Preface: Memorial Issue Dedicated to Thomas J. Dougherty. Photochem Photobiol. 2020 05; 96(3):453. PMID: 32531143.
    Citations:    
  3. Maytin EV, Hasan T. Vitamin D and Other Differentiation-promoting Agents as Neoadjuvants for Photodynamic Therapy of Cancer. Photochem Photobiol. 2020 05; 96(3):529-538. PMID: 32077114.
    Citations:    
  4. Khan S, Hussain MAB, Khan AP, Liu H, Siddiqui S, Mallidi S, Leon P, Daly L, Rudd G, Cuckov F, Hopper C, Bown SG, Akhtar K, Hasan SA, Siddiqui SA, Hasan T, Celli JP. Clinical evaluation of smartphone-based fluorescence imaging for guidance and monitoring of ALA-PDT treatment of early oral cancer. J Biomed Opt. 2020 Apr; 25(6):1-10. PMID: 32279466.
    Citations:    
  5. Feng Y, Palanisami A, Kuriakose J, Pigula M, Ashraf S, Hasan T. Novel Rapid Test for Detecting Carbapenemase. Emerg Infect Dis. 2020 Apr; 26(4):793-795. PMID: 32186503.
    Citations:    
  6. Nath S, Pigula M, Khan AP, Hanna W, Ruhi MK, Dehkordy FM, Pushpavanam K, Rege K, Moore K, Tsujita Y, Conrad C, Inci F, Carmen MGD, Franco W, Celli JP, Demirci U, Hasan T, Huang HC, Rizvi I. Flow-induced Shear Stress Confers Resistance to Carboplatin in an Adherent Three-Dimensional Model for Ovarian Cancer: A Role for EGFR-Targeted Photoimmunotherapy Informed by Physical Stress. J Clin Med. 2020 Mar 28; 9(4). PMID: 32231055.
    Citations:    
  7. Anbil S, Pigula M, Huang HC, Mallidi S, Broekgaarden M, Baglo Y, De Silva P, Simeone DM, Mino-Kenudson M, Maytin EV, Rizvi I, Hasan T. Vitamin D Receptor Activation and Photodynamic Priming Enables Durable Low-dose Chemotherapy. Mol Cancer Ther. 2020 Jun; 19(6):1308-1319. PMID: 32220968.
    Citations:    
  8. Feng Y, Palanisami A, Ashraf S, Bhayana B, Hasan T. Photodynamic inactivation of bacterial carbapenemases restores bacterial carbapenem susceptibility and enhances carbapenem antibiotic effectiveness. Photodiagnosis Photodyn Ther. 2020 Jun; 30:101693. PMID: 32173586.
    Citations:    
  9. Liang BJ, Pigula M, Baglo Y, Najafali D, Hasan T, Huang HC. Breaking the selectivity-uptake trade-off of photoimmunoconjugates with nanoliposomal irinotecan for synergistic multi-tier cancer targeting. J Nanobiotechnology. 2020 Jan 02; 18(1):1. PMID: 31898555.
    Citations:    
  10. Vincent P, Wang H, Nieskoski M, Gunn JR, Marra K, Hoopes J, Samkoe KS, Doyley M, Hasan T, Pogue B. High-resolution ex vivo elastography to characterize tumor stromal heterogeneity in situ in pancreatic adenocarcinoma. IEEE Trans Biomed Eng. 2020 Jan 01. PMID: 31902753.
    Citations:    
  11. Fisher C, Obaid G, Niu C, Foltz W, Goldstein A, Hasan T, Lilge L. Liposomal Lapatinib in Combination with Low-Dose Photodynamic Therapy for the Treatment of Glioma. J Clin Med. 2019 Dec 14; 8(12). PMID: 31847378.
    Citations:    
  12. Ruiz AJ, LaRochelle EPM, Gunn JR, Hull SM, Hasan T, Chapman MS, Pogue BW. Smartphone fluorescence imager for quantitative dosimetry of protoporphyrin-IX-based photodynamic therapy in skin. J Biomed Opt. 2019 12; 25(6):1-13. PMID: 31820594.
    Citations:    
  13. Nath S, Saad MA, Pigula M, Swain JWR, Hasan T. Photoimmunotherapy of Ovarian Cancer: A Unique Niche in the Management of Advanced Disease. Cancers (Basel). 2019 Nov 27; 11(12). PMID: 31783651.
    Citations:    
  14. Nath S, Obaid G, Hasan T. The Course of Immune Stimulation by Photodynamic Therapy: Bridging Fundamentals of Photochemically Induced Immunogenic Cell Death to the Enrichment of T-Cell Repertoire. Photochem Photobiol. 2019 11; 95(6):1288-1305. PMID: 31602649.
    Citations:    
  15. Mallidi S, Khan AP, Liu H, Daly L, Rudd G, Leon P, Khan S, Hussain BMA, Hasan SA, Siddique SA, Akhtar K, August M, Troulis M, Cuckov F, Celli JP, Hasan T. Platform for ergonomic intraoral photodynamic therapy using low-cost, modular 3D-printed components: Design, comfort and clinical evaluation. Sci Rep. 2019 11 01; 9(1):15830. PMID: 31676807.
    Citations:    
  16. Lu J, Roy B, Anderson M, Leggett CL, Levy MJ, Pogue B, Hasan T, Wang KK. Verteporfin- and sodium porfimer-mediated photodynamic therapy enhances pancreatic cancer cell death without activating stromal cells in the microenvironment. J Biomed Opt. 2019 11; 24(11):1-11. PMID: 31741351.
    Citations:    
  17. LaRochelle EPM, Chapman MS, Maytin EV, Hasan T, Pogue BW. Weather-informed Light-tissue Model-Based Dose Planning for Indoor Daylight Photodynamic Therapy. Photochem Photobiol. 2020 03; 96(2):320-326. PMID: 31581341.
    Citations:    
  18. Obaid G, Bano S, Mallidi S, Broekgaarden M, Kuriakose J, Silber Z, Bulin AL, Wang Y, Mai Z, Jin W, Simeone D, Hasan T. Impacting Pancreatic Cancer Therapy in Heterotypic in Vitro Organoids and in Vivo Tumors with Specificity-Tuned, NIR-Activable Photoimmunonanoconjugates: Towards Conquering Desmoplasia? Nano Lett. 2019 11 13; 19(11):7573-7587. PMID: 31518145.
    Citations:    
  19. Broekgaarden M, Bulin AL, Frederick J, Mai Z, Hasan T. Tracking Photodynamic- and Chemotherapy-Induced Redox-State Perturbations in 3D Culture Models of Pancreatic Cancer: A Tool for Identifying Therapy-Induced Metabolic Changes. J Clin Med. 2019 Sep 06; 8(9). PMID: 31500115.
    Citations:    
  20. Broekgaarden M, Anbil S, Bulin AL, Obaid G, Mai Z, Baglo Y, Rizvi I, Hasan T. Modulation of redox metabolism negates cancer-associated fibroblasts-induced treatment resistance in a heterotypic 3D culture platform of pancreatic cancer. Biomaterials. 2019 11; 222:119421. PMID: 31494503.
    Citations:    
  21. Bulin AL, Broekgaarden M, Simeone D, Hasan T. Low dose photodynamic therapy harmonizes with radiation therapy to induce beneficial effects on pancreatic heterocellular spheroids. Oncotarget. 2019 Apr 05; 10(27):2625-2643. PMID: 31080554.
    Citations:    
  22. Spring BQ, Lang RT, Kercher EM, Rizvi I, Wenham RM, Conejo-Garcia JR, Hasan T, Gatenby RA, Enderling H. Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies. Front Phys. 2019 Apr; 7. PMID: 31123672.
    Citations:    
  23. Rizvi I, Nath S, Obaid G, Ruhi MK, Moore K, Bano S, Kessel D, Hasan T. A Combination of Visudyne and a Lipid-anchored Liposomal Formulation of Benzoporphyrin Derivative Enhances Photodynamic Therapy Efficacy in a 3D Model for Ovarian Cancer. Photochem Photobiol. 2019 01; 95(1):419-429. PMID: 30499113.
    Citations:    Fields:    
  24. Pigula M, Huang HC, Mallidi S, Anbil S, Liu J, Mai Z, Hasan T. Size-dependent Tumor Response to Photodynamic Therapy and Irinotecan Monotherapies Revealed by Longitudinal Ultrasound Monitoring in an Orthotopic Pancreatic Cancer Model. Photochem Photobiol. 2019 01; 95(1):378-386. PMID: 30229942.
    Citations:    Fields:    
  25. Obaid G, Jin W, Bano S, Kessel D, Hasan T. Nanolipid Formulations of Benzoporphyrin Derivative: Exploring the Dependence of Nanoconstruct Photophysics and Photochemistry on Their Therapeutic Index in Ovarian Cancer Cells. Photochem Photobiol. 2019 01; 95(1):364-377. PMID: 30125366.
    Citations:    Fields:    
  26. Liu H, Daly L, Rudd G, Khan AP, Mallidi S, Liu Y, Cuckov F, Hasan T, Celli JP. Development and evaluation of a low-cost, portable, LED-based device for PDT treatment of early-stage oral cancer in resource-limited settings. Lasers Surg Med. 2019 04; 51(4):345-351. PMID: 30168618.
    Citations:    Fields:    
  27. Huang HC, Pigula M, Fang Y, Hasan T. Immobilization of Photo-Immunoconjugates on Nanoparticles Leads to Enhanced Light-Activated Biological Effects. Small. 2018 Jul 01; e1800236. PMID: 29962083.
    Citations:    Fields:    
  28. Marra K, LaRochelle EP, Chapman MS, Hoopes PJ, Lukovits K, Maytin EV, Hasan T, Pogue BW. Comparison of Blue and White Lamp Light with Sunlight for Daylight-Mediated, 5-ALA Photodynamic Therapy, in vivo. Photochem Photobiol. 2018 09; 94(5):1049-1057. PMID: 29663426.
    Citations: 1     Fields:    
  29. Rizvi I, Obaid G, Bano S, Hasan T, Kessel D. Photodynamic therapy: Promoting in vitro efficacy of photodynamic therapy by liposomal formulations of a photosensitizing agent. Lasers Surg Med. 2018 07; 50(5):499-505. PMID: 29527710.
    Citations:    Fields:    
  30. Broekgaarden M, Rizvi I, Bulin AL, Petrovic L, Goldschmidt R, Massodi I, Celli JP, Hasan T. Neoadjuvant photodynamic therapy augments immediate and prolonged oxaliplatin efficacy in metastatic pancreatic cancer organoids. Oncotarget. 2018 Feb 27; 9(16):13009-13022. PMID: 29560127.
    Citations: 1     Fields:    
  31. Bulin AL, Broekgaarden M, Hasan T. Comprehensive high-throughput image analysis for therapeutic efficacy of architecturally complex heterotypic organoids. Sci Rep. 2017 11 30; 7(1):16645. PMID: 29192263.
    Citations: 1     Fields:    
  32. Huang HC, Rizvi I, Liu J, Anbil S, Kalra A, Lee H, Baglo Y, Paz N, Hayden D, Pereira S, Pogue BW, Fitzgerald J, Hasan T. Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery. Cancer Res. 2018 01 15; 78(2):558-571. PMID: 29187403.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Huang HC, Liu J, Baglo Y, Rizvi I, Anbil S, Pigula M, Hasan T. Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis. Mol Cancer Ther. 2018 02; 17(2):508-520. PMID: 29167313.
    Citations:    Fields:    
  34. de Souza ALR, LaRochelle E, Marra K, Gunn J, Davis SC, Samkoe KS, Chapman MS, Maytin EV, Hasan T, Pogue BW. Assessing daylight & low-dose rate photodynamic therapy efficacy, using biomarkers of photophysical, biochemical and biological damage metrics in situ. Photodiagnosis Photodyn Ther. 2017 Dec; 20:227-233. PMID: 29037911.
    Citations: 2     Fields:    Translation:AnimalsCells
  35. Nieskoski MD, Marra K, Gunn JR, Hoopes PJ, Doyley MM, Hasan T, Trembly BS, Pogue BW. Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer. Sci Rep. 2017 08 30; 7(1):10093. PMID: 28855644.
    Citations:    Fields:    
  36. Obaid G, Spring BQ, Bano S, Hasan T. Activatable clinical fluorophore-quencher antibody pairs as dual molecular probes for the enhanced specificity of image-guided surgery. J Biomed Opt. 2017 Aug; 22(12):1-6. PMID: 28853247.
    Citations:    Fields:    Translation:Animals
  37. Nieskoski MD, Marra K, Gunn JR, Kanick SC, Doyley MM, Hasan T, Pereira SP, Stuart Trembly B, Pogue BW. Separation of Solid Stress From Interstitial Fluid Pressure in Pancreas Cancer Correlates With Collagen Area Fraction. J Biomech Eng. 2017 Jun 01; 139(6). PMID: 28388715.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  38. Anand S, Rollakanti KR, Brankov N, Brash DE, Hasan T, Maytin EV. Fluorouracil Enhances Photodynamic Therapy of Squamous Cell Carcinoma via a p53-Independent Mechanism that Increases Protoporphyrin IX levels and Tumor Cell Death. Mol Cancer Ther. 2017 06; 16(6):1092-1101. PMID: 28336806.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  39. Lee HH, Choi MG, Hasan T. Application of photodynamic therapy in gastrointestinal disorders: an outdated or re-emerging technique? Korean J Intern Med. 2017 Jan; 32(1):1-10. PMID: 28049283.
    Citations: 2     Fields:    Translation:Humans
  40. Mallidi S, Anbil S, Bulin AL, Obaid G, Ichikawa M, Hasan T. Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy. Theranostics. 2016; 6(13):2458-2487. PMID: 27877247.
    Citations: 8     Fields:    Translation:Humans
  41. de Souza AL, Marra K, Gunn J, Samkoe KS, Kanick SC, Davis SC, Chapman MS, Maytin EV, Hasan T, Pogue BW. Comparing desferrioxamine and light fractionation enhancement of ALA-PpIX photodynamic therapy in skin cancer. Br J Cancer. 2016 09 27; 115(7):805-13. PMID: 27575852.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  42. Palanisami A, Khan S, Erdem SS, Hasan T. Guiding Empiric Treatment for Serious Bacterial Infections via Point of Care [Formula: see text]-Lactamase Characterization. IEEE J Transl Eng Health Med. 2016; 4:2800410. PMID: 27602307.
    Citations: 1     
  43. Obaid G, Broekgaarden M, Bulin AL, Huang HC, Kuriakose J, Liu J, Hasan T. Photonanomedicine: a convergence of photodynamic therapy and nanotechnology. Nanoscale. 2016 Jul 07; 8(25):12471-503. PMID: 27328309.
    Citations: 2     Fields:    
  44. Wang S, Hüttmann G, Scholzen T, Zhang Z, Vogel A, Hasan T, Rahmanzadeh R. A light-controlled switch after dual targeting of proliferating tumor cells via the membrane receptor EGFR and the nuclear protein Ki-67. Sci Rep. 2016 06 01; 6:27032. PMID: 27246531.
    Citations: 4     Fields:    Translation:HumansCells
  45. Pogue BW, Paulsen KD, Samkoe KS, Elliott JT, Hasan T, Strong TV, Draney DR, Feldwisch J. Vision 20/20: Molecular-guided surgical oncology based upon tumor metabolism or immunologic phenotype: Technological pathways for point of care imaging and intervention. Med Phys. 2016 Jun; 43(6):3143-3156. PMID: 27277060.
    Citations: 2     Fields:    
  46. Kim IW, Park JM, Roh YJ, Kim JH, Choi MG, Hasan T. Direct measurement of singlet oxygen by using a photomultiplier tube-based detection system. J Photochem Photobiol B. 2016 Jun; 159:14-23. PMID: 26995671.
    Citations: 1     Fields:    Translation:HumansCells
  47. Pogue BW, Elliott JT, Kanick SC, Davis SC, Samkoe KS, Maytin EV, Pereira SP, Hasan T. Revisiting photodynamic therapy dosimetry: reductionist & surrogate approaches to facilitate clinical success. Phys Med Biol. 2016 Apr 07; 61(7):R57-89. PMID: 26961864.
    Citations: 4     Fields:    
  48. Spring BQ, Bryan Sears R, Zheng LZ, Mai Z, Watanabe R, Sherwood ME, Schoenfeld DA, Pogue BW, Pereira SP, Villa E, Hasan T. A photoactivable multi-inhibitor nanoliposome for tumour control and simultaneous inhibition of treatment escape pathways. Nat Nanotechnol. 2016 Apr; 11(4):378-87. PMID: 26780659.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  49. Huang HC, Mallidi S, Liu J, Chiang CT, Mai Z, Goldschmidt R, Ebrahim-Zadeh N, Rizvi I, Hasan T. Photodynamic Therapy Synergizes with Irinotecan to Overcome Compensatory Mechanisms and Improve Treatment Outcomes in Pancreatic Cancer. Cancer Res. 2016 Mar 01; 76(5):1066-77. PMID: 26719532.
    Citations: 7     Fields:    Translation:HumansAnimals
  50. Tangutoori S, Spring BQ, Mai Z, Palanisami A, Mensah LB, Hasan T. Simultaneous delivery of cytotoxic and biologic therapeutics using nanophotoactivatable liposomes enhances treatment efficacy in a mouse model of pancreatic cancer. Nanomedicine. 2016 Jan; 12(1):223-34. PMID: 26390832.
    Citations: 5     Fields:    Translation:Animals
  51. Kushibiki T, Tu Y, Abu-Yousif AO, Hasan T. Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation. Sci Rep. 2015 Aug 17; 5:13114. PMID: 26279470.
    Citations: 2     Fields:    Translation:AnimalsCells
  52. Wang S, Hüttmann G, Zhang Z, Vogel A, Birngruber R, Tangutoori S, Hasan T, Rahmanzadeh R. Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67. Mol Pharm. 2015 Sep 08; 12(9):3272-81. PMID: 26226545.
    Citations: 4     Fields:    Translation:HumansCells
  53. Kim JH, Park JM, Roh YJ, Kim IW, Hasan T, Choi MG. Enhanced efficacy of photodynamic therapy by inhibiting ABCG2 in colon cancers. BMC Cancer. 2015 Jul 07; 15:504. PMID: 26149077.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  54. Hempstead J, Jones DP, Ziouche A, Cramer GM, Rizvi I, Arnason S, Hasan T, Celli JP. Low-cost photodynamic therapy devices for global health settings: Characterization of battery-powered LED performance and smartphone imaging in 3D tumor models. Sci Rep. 2015 May 12; 5:10093. PMID: 25965295.
    Citations: 5     Fields:    Translation:Humans
  55. Mallidi S, Spring BQ, Hasan T. Optical Imaging, Photodynamic Therapy and Optically Triggered Combination Treatments. Cancer J. 2015 May-Jun; 21(3):194-205. PMID: 26049699.
    Citations: 6     Fields:    Translation:Humans
  56. Spring BQ, Rizvi I, Xu N, Hasan T. The role of photodynamic therapy in overcoming cancer drug resistance. Photochem Photobiol Sci. 2015 Aug; 14(8):1476-91. PMID: 25856800.
    Citations: 21     Fields:    Translation:HumansAnimals
  57. Mallidi S, Mai Z, Rizvi I, Hempstead J, Arnason S, Celli J, Hasan T. In vivo evaluation of battery-operated light-emitting diode-based photodynamic therapy efficacy using tumor volume and biomarker expression as endpoints. J Biomed Opt. 2015 Apr; 20(4):048003. PMID: 25909707.
    Citations: 1     Fields:    Translation:AnimalsCells
  58. Elliott JT, Samkoe KS, Gunn JR, Stewart EE, Gardner TB, Tichauer KM, Lee TY, Hoopes PJ, Pereira SP, Hasan T, Pogue BW. Perfusion CT estimates photosensitizer uptake and biodistribution in a rabbit orthotopic pancreatic cancer model: a pilot study. Acad Radiol. 2015 May; 22(5):572-9. PMID: 25683500.
    Citations: 2     Fields:    Translation:Animals
  59. Mallidi S, Watanabe K, Timerman D, Schoenfeld D, Hasan T. Prediction of tumor recurrence and therapy monitoring using ultrasound-guided photoacoustic imaging. Theranostics. 2015; 5(3):289-301. PMID: 25553116.
    Citations: 24     Fields:    Translation:Animals
  60. Frenette M, Hatamimoslehabadi M, Bellinger-Buckley S, Laoui S, La J, Bag S, Mallidi S, Hasan T, Bouma B, Yelleswarapu C, Rochford J. Shining light on the dark side of imaging: excited state absorption enhancement of a bis-styryl BODIPY photoacoustic contrast agent. J Am Chem Soc. 2014 Nov 12; 136(45):15853-6. PMID: 25329769.
    Citations: 5     Fields:    Translation:Cells
  61. Tichauer KM, Samkoe KS, Gunn JR, Kanick SC, Hoopes PJ, Barth RJ, Kaufman PA, Hasan T, Pogue BW. Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging. Nat Med. 2014 Nov; 20(11):1348-53. PMID: 25344739.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  62. Samkoe KS, Tichauer KM, Gunn JR, Wells WA, Hasan T, Pogue BW. Quantitative in vivo immunohistochemistry of epidermal growth factor receptor using a receptor concentration imaging approach. Cancer Res. 2014 Dec 15; 74(24):7465-74. PMID: 25344226.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  63. Spring BQ, Palanisami A, Hasan T. Microscale receiver operating characteristic analysis of micrometastasis recognition using activatable fluorescent probes indicates leukocyte imaging as a critical factor to enhance accuracy. J Biomed Opt. 2014 Jun; 19(6):066006. PMID: 24919449.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  64. Anand S, Rollakanti KR, Horst RL, Hasan T, Maytin EV. Combination of oral vitamin D3 with photodynamic therapy enhances tumor cell death in a murine model of cutaneous squamous cell carcinoma. Photochem Photobiol. 2014 Sep-Oct; 90(5):1126-35. PMID: 24807677.
    Citations: 8     Fields:    Translation:HumansAnimals
  65. Ghogare AA, Rizvi I, Hasan T, Greer A. "Pointsource" delivery of a photosensitizer drug and singlet oxygen: eradication of glioma cells in vitro. Photochem Photobiol. 2014 Sep-Oct; 90(5):1119-25. PMID: 24673689.
    Citations: 2     Fields:    Translation:HumansCells
  66. Khan S, Sallum UW, Zheng X, Nau GJ, Hasan T. Rapid optical determination of ß-lactamase and antibiotic activity. BMC Microbiol. 2014 Apr 04; 14:84. PMID: 24708478.
    Citations: 2     Fields:    Translation:HumansCells
  67. Jermyn M, Davis SC, Dehghani H, Huggett MT, Hasan T, Pereira SP, Bown SG, Pogue BW. CT contrast predicts pancreatic cancer treatment response to verteporfin-based photodynamic therapy. Phys Med Biol. 2014 Apr 21; 59(8):1911-21. PMID: 24651456.
    Citations: 2     Fields:    Translation:Humans
  68. Hamzei N, Samkoe KS, Elliott JT, Holt RW, Gunn JR, Hasan T, Pogue BW, Tichauer KM. Comparison of Kinetic Models for Dual-Tracer Receptor Concentration Imaging in Tumors. Austin J Biomed Eng. 2014 Mar 05; 1(1). PMID: 25414912.
    Citations: 8     
  69. Spring BQ, Abu-Yousif AO, Palanisami A, Rizvi I, Zheng X, Mai Z, Anbil S, Sears RB, Mensah LB, Goldschmidt R, Erdem SS, Oliva E, Hasan T. Selective treatment and monitoring of disseminated cancer micrometastases in vivo using dual-function, activatable immunoconjugates. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):E933-42. PMID: 24572574.
    Citations: 24     Fields:    Translation:Animals
  70. Mallidi S, Anbil S, Lee S, Manstein D, Elrington S, Kositratna G, Schoenfeld D, Pogue B, Davis SJ, Hasan T. Photosensitizer fluorescence and singlet oxygen luminescence as dosimetric predictors of topical 5-aminolevulinic acid photodynamic therapy induced clinical erythema. J Biomed Opt. 2014 Feb; 19(2):028001. PMID: 24503639.
    Citations: 6     Fields:    Translation:Humans
  71. Celli JP, Rizvi I, Blanden AR, Massodi I, Glidden MD, Pogue BW, Hasan T. An imaging-based platform for high-content, quantitative evaluation of therapeutic response in 3D tumour models. Sci Rep. 2014 Jan 17; 4:3751. PMID: 24435043.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  72. Erdem SS, Khan S, Palanisami A, Hasan T. Rapid, low-cost fluorescent assay of ß-lactamase-derived antibiotic resistance and related antibiotic susceptibility. J Biomed Opt. 2014; 19(10):105007. PMID: 25321396.
    Citations: 1     Fields:    Translation:Cells
  73. Kanick SC, Davis SC, Zhao Y, Hasan T, Maytin EV, Pogue BW, Chapman MS. Dual-channel red/blue fluorescence dosimetry with broadband reflectance spectroscopic correction measures protoporphyrin IX production during photodynamic therapy of actinic keratosis. J Biomed Opt. 2014; 19(7):75002. PMID: 24996661.
    Citations: 10     Fields:    Translation:Humans
  74. Samkoe KS, Bryant A, Gunn JR, Pereira SP, Hasan T, Pogue BW. Contrast enhanced-magnetic resonance imaging as a surrogate to map verteporfin delivery in photodynamic therapy. J Biomed Opt. 2013 Dec; 18(12):120504. PMID: 24365954.
    Citations: 1     Fields:    Translation:Animals
  75. Tichauer KM, Deharvengt SJ, Samkoe KS, Gunn JR, Bosenberg MW, Turk MJ, Hasan T, Stan RV, Pogue BW. Tumor endothelial marker imaging in melanomas using dual-tracer fluorescence molecular imaging. Mol Imaging Biol. 2014 Jun; 16(3):372-82. PMID: 24217944.
    Citations: 5     Fields:    Translation:Animals
  76. Anbil S, Rizvi I, Celli JP, Alagic N, Pogue BW, Hasan T. Impact of treatment response metrics on photodynamic therapy planning and outcomes in a three-dimensional model of ovarian cancer. J Biomed Opt. 2013 Sep; 18(9):098004. PMID: 24802230.
    Citations: 5     Fields:    Translation:HumansCells
  77. Anand S, Hasan T, Maytin EV. Mechanism of differentiation-enhanced photodynamic therapy for cancer: upregulation of coproporphyrinogen oxidase by C/EBP transcription factors. Mol Cancer Ther. 2013 Aug; 12(8):1638-50. PMID: 23686770.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  78. Davis SC, Samkoe KS, Tichauer KM, Sexton KJ, Gunn JR, Deharvengt SJ, Hasan T, Pogue BW. Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9025-30. PMID: 23671066.
    Citations: 16     Fields:    Translation:AnimalsCells
  79. Rizvi I, Gurkan UA, Tasoglu S, Alagic N, Celli JP, Mensah LB, Mai Z, Demirci U, Hasan T. Flow induces epithelial-mesenchymal transition, cellular heterogeneity and biomarker modulation in 3D ovarian cancer nodules. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):E1974-83. PMID: 23645635.
    Citations: 35     Fields:    Translation:Humans
  80. Bartusik D, Aebisher D, Ghogare A, Ghosh G, Abramova I, Hasan T, Greer A. A fiberoptic (photodynamic therapy type) device with a photosensitizer and singlet oxygen delivery probe tip for ovarian cancer cell killing. Photochem Photobiol. 2013 Jul-Aug; 89(4):936-41. PMID: 23495787.
    Citations: 4     Fields:    Translation:HumansCells
  81. Rizvi I, Anbil S, Alagic N, Celli J, Celli JP, Zheng LZ, Palanisami A, Glidden MD, Pogue BW, Hasan T. PDT dose parameters impact tumoricidal durability and cell death pathways in a 3D ovarian cancer model. Photochem Photobiol. 2013 Jul-Aug; 89(4):942-52. PMID: 23442192.
    Citations: 8     Fields:    Translation:HumansCells
  82. Mir Y, Elrington SA, Hasan T. A new nanoconstruct for epidermal growth factor receptor-targeted photo-immunotherapy of ovarian cancer. Nanomedicine. 2013 Oct; 9(7):1114-22. PMID: 23485748.
    Citations: 9     Fields:    Translation:HumansCells
  83. Kimani S, Ghosh G, Ghogare A, Rudshteyn B, Bartusik D, Hasan T, Greer A. Synthesis and characterization of mono-, di-, and tri-poly(ethylene glycol) chlorin e6 conjugates for the photokilling of human ovarian cancer cells. J Org Chem. 2012 Dec 07; 77(23):10638-47. PMID: 23126407.
    Citations: 5     Fields:    Translation:Humans
  84. Hasan T. Using cellular mechanisms to develop effective combinations of photodynamic therapy and targeted therapies. J Natl Compr Canc Netw. 2012 Oct 01; 10 Suppl 2:S23-6. PMID: 23055209.
    Citations: 1     Fields:    Translation:HumansAnimals
  85. Tichauer KM, Samkoe KS, Sexton KJ, Hextrum SK, Yang HH, Klubben WS, Gunn JR, Hasan T, Pogue BW. In vivo quantification of tumor receptor binding potential with dual-reporter molecular imaging. Mol Imaging Biol. 2012 Oct; 14(5):584-92. PMID: 22203241.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  86. Glidden MD, Celli JP, Massodi I, Rizvi I, Pogue BW, Hasan T. Image-Based Quantification of Benzoporphyrin Derivative Uptake, Localization, and Photobleaching in 3D Tumor Models, for Optimization of PDT Parameters. Theranostics. 2012; 2(9):827-39. PMID: 23082096.
    Citations: 8     Fields:    
  87. Rizvi I, Dinh TA, Yu W, Chang Y, Sherwood ME, Hasan T. Photoimmunotherapy and irradiance modulation reduce chemotherapy cycles and toxicity in a murine model for ovarian carcinomatosis: perspective and results. Isr J Chem. 2012 Sep; 52(8-9):776-787. PMID: 23626376.
    Citations: 10     
  88. Maytin EV, Honari G, Khachemoune A, Taylor CR, Ortel B, Pogue BW, Sznycer-Taub N, Hasan T. Vitamin D Combined with Aminolevulinate (ALA)-Mediated Photodynamic Therapy (PDT) for Human Psoriasis: A Proof-of-Principle Study. Isr J Chem. 2012 Sep; 52(8-9):767-775. PMID: 23264699.
    Citations: 4     
  89. Dhar DK, Olde Damink SW, Brindley JH, Godfrey A, Chapman MH, Sandanayake NS, Andreola F, Mazurek S, Hasan T, Malago M, Pereira SP. Pyruvate kinase M2 is a novel diagnostic marker and predicts tumor progression in human biliary tract cancer. Cancer. 2013 Feb 01; 119(3):575-85. PMID: 22864959.
    Citations: 11     Fields:    Translation:HumansCells
  90. Samkoe KS, Sexton K, Tichauer KM, Hextrum SK, Pardesi O, Davis SC, O'Hara JA, Hoopes PJ, Hasan T, Pogue BW. High vascular delivery of EGF, but low receptor binding rate is observed in AsPC-1 tumors as compared to normal pancreas. Mol Imaging Biol. 2012 Aug; 14(4):472-9. PMID: 21847690.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  91. Torosean S, Flynn B, Axelsson J, Gunn J, Samkoe KS, Hasan T, Doyley MM, Pogue BW. Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure. Nanomedicine. 2013 Feb; 9(2):151-8. PMID: 22841910.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  92. Anand S, Ortel BJ, Pereira SP, Hasan T, Maytin EV. Biomodulatory approaches to photodynamic therapy for solid tumors. Cancer Lett. 2012 Dec 29; 326(1):8-16. PMID: 22842096.
    Citations: 22     Fields:    Translation:Humans
  93. Tichauer KM, Samkoe KS, Sexton KJ, Gunn JR, Hasan T, Pogue BW. Improved tumor contrast achieved by single time point dual-reporter fluorescence imaging. J Biomed Opt. 2012 Jun; 17(6):066001. PMID: 22734757.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  94. Abu-Yousif AO, Moor AC, Zheng X, Savellano MD, Yu W, Selbo PK, Hasan T. Epidermal growth factor receptor-targeted photosensitizer selectively inhibits EGFR signaling and induces targeted phototoxicity in ovarian cancer cells. Cancer Lett. 2012 Aug 28; 321(2):120-7. PMID: 22266098.
    Citations: 12     Fields:    Translation:HumansCells
  95. Celli JP, Solban N, Liang A, Pereira SP, Hasan T. Verteporfin-based photodynamic therapy overcomes gemcitabine insensitivity in a panel of pancreatic cancer cell lines. Lasers Surg Med. 2011 Sep; 43(7):565-74. PMID: 22057484.
    Citations: 30     Fields:    Translation:HumansCells
  96. Evans CL, Abu-Yousif AO, Park YJ, Klein OJ, Celli JP, Rizvi I, Zheng X, Hasan T. Killing hypoxic cell populations in a 3D tumor model with EtNBS-PDT. PLoS One. 2011; 6(8):e23434. PMID: 21876751.
    Citations: 24     Fields:    Translation:HumansCells
  97. Anand S, Wilson C, Hasan T, Maytin EV. Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy. Cancer Res. 2011 Sep 15; 71(18):6040-50. PMID: 21807844.
    Citations: 23     Fields:    Translation:HumansAnimals
  98. Kosaka S, Miyoshi N, Akilov OE, Hasan T, Kawana S. Targeting of sebaceous glands by d-aminolevulinic acid-based photodynamic therapy: An in vivo study. Lasers Surg Med. 2011 Jul; 43(5):376-81. PMID: 21674542.
    Citations: 3     Fields:    Translation:Animals
  99. Akilov OE, Wu MX, Jin Y, Zhou Z, Geskin LJ, Falo LD, Hasan T. Vaccination with photodynamic therapy-treated macrophages induces highly suppressive T-regulatory cells. Photodermatol Photoimmunol Photomed. 2011 Apr; 27(2):97-107. PMID: 21392113.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Xu F, Celli J, Rizvi I, Moon S, Hasan T, Demirci U. A three-dimensional in vitro ovarian cancer coculture model using a high-throughput cell patterning platform. Biotechnol J. 2011 Feb; 6(2):204-212. PMID: 21298805.
    Citations: 34     Fields:    Translation:HumansCells
  101. Kim KH, Park BH, Tu Y, Hasan T, Lee B, Li J, de Boer JF. Polarization-sensitive optical frequency domain imaging based on unpolarized light. Opt Express. 2011 Jan 17; 19(2):552-61. PMID: 21263595.
    Citations: 9     Fields:    
  102. Rizvi I, Celli JP, Evans CL, Abu-Yousif AO, Muzikansky A, Pogue BW, Finkelstein D, Hasan T. Synergistic enhancement of carboplatin efficacy with photodynamic therapy in a three-dimensional model for micrometastatic ovarian cancer. Cancer Res. 2010 Nov 15; 70(22):9319-28. PMID: 21062986.
    Citations: 41     Fields:    Translation:HumansCells
  103. Rahmanzadeh R, Rai P, Celli JP, Rizvi I, Baron-Lühr B, Gerdes J, Hasan T. Ki-67 as a molecular target for therapy in an in vitro three-dimensional model for ovarian cancer. Cancer Res. 2010 Nov 15; 70(22):9234-42. PMID: 21045152.
    Citations: 15     Fields:    Translation:HumansCells
  104. Sallum UW, Zheng X, Verma S, Hasan T. Rapid functional definition of extended spectrum ß-lactamase activity in bacterial cultures via competitive inhibition of fluorescent substrate cleavage. Photochem Photobiol. 2010 Nov-Dec; 86(6):1267-71. PMID: 20854415.
    Citations: 2     Fields:    Translation:Cells
  105. Celli JP, Rizvi I, Evans CL, Abu-Yousif AO, Hasan T. Quantitative imaging reveals heterogeneous growth dynamics and treatment-dependent residual tumor distributions in a three-dimensional ovarian cancer model. J Biomed Opt. 2010 Sep-Oct; 15(5):051603. PMID: 21054077.
    Citations: 30     Fields:    Translation:HumansCells
  106. Rai P, Mallidi S, Zheng X, Rahmanzadeh R, Mir Y, Elrington S, Khurshid A, Hasan T. Development and applications of photo-triggered theranostic agents. Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1094-124. PMID: 20858520.
    Citations: 46     Fields:    Translation:HumansAnimals
  107. Kosaka S, Yasumoto M, Akilov OE, Hasan T, Kawana S. Comparative split-face study of 5-aminolevulinic acid photodynamic therapy with intense pulsed light for photorejuvenation of Asian skin. J Dermatol. 2010 Dec; 37(12):1005-10. PMID: 21083701.
    Citations: 2     Fields:    Translation:Humans
  108. Abu-Yousif AO, Hett EC, Skoczenski AM, Hasan T. The ABC's of industry: a postdoc program provides a sneak peek into industry careers. Nat Biotechnol. 2010 Jun; 28(6):625-6. PMID: 20531344.
    Citations: 1     Fields:    
  109. Latorre-Esteves E, Akilov OE, Rai P, Beverley SM, Hasan T. Monitoring the efficacy of antimicrobial photodynamic therapy in a murine model of cutaneous leishmaniasis using L. major expressing GFP. J Biophotonics. 2010 Jun; 3(5-6):328-35. PMID: 20376860.
    Citations: 3     Fields:    Translation:Animals
  110. Celli JP, Spring BQ, Rizvi I, Evans CL, Samkoe KS, Verma S, Pogue BW, Hasan T. Imaging and photodynamic therapy: mechanisms, monitoring, and optimization. Chem Rev. 2010 May 12; 110(5):2795-838. PMID: 20353192.
    Citations: 120     Fields: &n