Harvard Catalyst Profiles

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Ed Harlow, Ph.D.

Title
Institution
Department
Address
Phone

Mentoring
Localization of PRB-Repressed Promoters in Relation to PRB Nuclear FOCI in Confluent Human Fibroblasts
Part Time/Continuation, 09/01/98 - 05/01/99

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21MH087394 (HARLOW, EDWARD E) Jul 4, 2009 - Apr 30, 2011
    NIH/NIMH
    How Genetic Variation in Protein Kinases Affects Drug Response
    Role: Principal Investigator
  2. P01CA080111 (WEINBERG, ROBERT A) Mar 18, 1999 - Jan 31, 2019
    NIH/NCI
    Mechanisms of Breast Development and Carcinogenesis
    Role: Co-Principal Investigator
  3. R01CA060636 (HARLOW, EDWARD E) Aug 5, 1993 - Mar 31, 2005
    NIH/NCI
    FUNCTION OF THE RETINOBLASTOMA PROTEIN
    Role: Principal Investigator
  4. R01CA074498 (HARLOW, EDWARD E) Sep 30, 1992 - Aug 31, 2003
    NIH/NCI
    CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE
    Role: Principal Investigator
  5. R01GM048628 (HARLOW, EDWARD E) Sep 30, 1992 - Aug 31, 1996
    NIH/NIGMS
    CDC2-RELATED KINASES AND THE CONTROL OF CELL CYCLE
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
DNA Resource Core (DF/HCC) - Core services (7), Gene knockdown screening libraries (1), Instruments (7), Plasmids (2) and cDNA libraries (2)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS. GRK3 is essential for metastatic cells and promotes prostate tumor progression. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1521-6. PMID: 24434559.
    Citations: 11     Fields:    Translation:Humans
  2. Demarest SJ, Gardner J, Vendel MC, Ailor E, Szak S, Huang F, Doern A, Tan X, Yang W, Grueneberg DA, Richards EJ, Endege WO, Harlow E, Koopman LA. Evaluation of Tyro3 expression, Gas6-mediated Akt phosphorylation, and the impact of anti-Tyro3 antibodies in melanoma cell lines. Biochemistry. 2013 May 07; 52(18):3102-18. PMID: 23570341.
    Citations: 12     Fields:    Translation:HumansCells
  3. Tschöp K, Conery AR, Litovchick L, Decaprio JA, Settleman J, Harlow E, Dyson N. A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev. 2011 Apr 15; 25(8):814-30. PMID: 21498571.
    Citations: 48     Fields:    Translation:HumansCells
  4. Gonzalez-Malerva L, Park J, Zou L, Hu Y, Moradpour Z, Pearlberg J, Sawyer J, Stevens H, Harlow E, LaBaer J. High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):2058-63. PMID: 21233418.
    Citations: 25     Fields:    Translation:HumansCells
  5. Conery AR, Sever S, Harlow E. Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15461-6. PMID: 20713695.
    Citations: 16     Fields:    Translation:HumansCells
  6. Conery AR, Harlow E. High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15455-60. PMID: 20713694.
    Citations: 7     Fields:    Translation:HumansCells
  7. Baldwin A, Grueneberg DA, Hellner K, Sawyer J, Grace M, Li W, Harlow E, Munger K. Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12463-8. PMID: 20616055.
    Citations: 19     Fields:    Translation:HumansCells
  8. Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochem Pharmacol. 2010 Apr 15; 79(8):1118-24. PMID: 20005212.
    Citations: 76     Fields:    Translation:HumansCells
  9. Malumbres M, Harlow E, Hunt T, Hunter T, Lahti JM, Manning G, Morgan DO, Tsai LH, Wolgemuth DJ. Cyclin-dependent kinases: a family portrait. Nat Cell Biol. 2009 Nov; 11(11):1275-6. PMID: 19884882.
    Citations: 96     Fields:    Translation:HumansCells
  10. Grueneberg DA, Li W, Davies JE, Sawyer J, Pearlberg J, Harlow E. Kinase requirements in human cells: IV. Differential kinase requirements in cervical and renal human tumor cell lines. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16490-5. PMID: 18948597.
    Citations: 15     Fields:    Translation:HumansCells
  11. Grueneberg DA, Degot S, Pearlberg J, Li W, Davies JE, Baldwin A, Endege W, Doench J, Sawyer J, Hu Y, Boyce F, Xian J, Munger K, Harlow E. Kinase requirements in human cells: I. Comparing kinase requirements across various cell types. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16472-7. PMID: 18948591.
    Citations: 35     Fields:    Translation:HumansCells
  12. Bommi-Reddy A, Almeciga I, Sawyer J, Geisen C, Li W, Harlow E, Kaelin WG, Grueneberg DA. Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16484-9. PMID: 18948595.
    Citations: 54     Fields:    Translation:HumansCells
  13. Baldwin A, Li W, Grace M, Pearlberg J, Harlow E, Münger K, Grueneberg DA. Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16478-83. PMID: 18948598.
    Citations: 23     Fields:    Translation:HumansCells
  14. Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J. Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr; 17(4):536-43. PMID: 17322287.
    Citations: 55     Fields:    Translation:AnimalsCells
  15. Park J, Hu Y, Murthy TV, Vannberg F, Shen B, Rolfs A, Hutti JE, Cantley LC, Labaer J, Harlow E, Brizuela L. Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8114-9. PMID: 15928075.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  16. Pearlberg J, Degot S, Endege W, Park J, Davies J, Gelfand E, Sawyer J, Conery A, Doench J, Li W, Gonzalez L, Boyce FM, Brizuela L, Labaer J, Grueneberg D, Harlow E. Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells. Cold Spring Harb Symp Quant Biol. 2005; 70:449-59. PMID: 16869783.
    Citations: 14     Fields:    Translation:HumansCells
  17. Johnson BR, Nitta RT, Frock RL, Mounkes L, Barbie DA, Stewart CL, Harlow E, Kennedy BK. A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9677-82. PMID: 15210943.
    Citations: 92     Fields:    Translation:AnimalsCells
  18. Barbie DA, Kudlow BA, Frock R, Zhao J, Johnson BR, Dyson N, Harlow E, Kennedy BK. Nuclear reorganization of mammalian DNA synthesis prior to cell cycle exit. Mol Cell Biol. 2004 Jan; 24(2):595-607. PMID: 14701733.
    Citations: 15     Fields:    Translation:HumansCells
  19. Kohn MJ, Bronson RT, Harlow E, Dyson NJ, Yamasaki L. Dp1 is required for extra-embryonic development. Development. 2003 Apr; 130(7):1295-305. PMID: 12588846.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Classon M, Harlow E. The retinoblastoma tumour suppressor in development and cancer. Nat Rev Cancer. 2002 Dec; 2(12):910-7. PMID: 12459729.
    Citations: 218     Fields:    Translation:HumansAnimalsCells
  21. Fingar DC, Salama S, Tsou C, Harlow E, Blenis J. Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev. 2002 Jun 15; 16(12):1472-87. PMID: 12080086.
    Citations: 352     Fields:    Translation:HumansAnimalsCells
  22. Braun P, Hu Y, Shen B, Halleck A, Koundinya M, Harlow E, LaBaer J. Proteome-scale purification of human proteins from bacteria. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2654-9. PMID: 11880620.
    Citations: 69     Fields:    Translation:HumansCells
  23. Lee SB, Kim SH, Bell DW, Wahrer DC, Schiripo TA, Jorczak MM, Sgroi DC, Garber JE, Li FP, Nichols KE, Varley JM, Godwin AK, Shannon KM, Harlow E, Haber DA. Destabilization of CHK2 by a missense mutation associated with Li-Fraumeni Syndrome. Cancer Res. 2001 Nov 15; 61(22):8062-7. PMID: 11719428.
    Citations: 31     Fields:    Translation:HumansCells
  24. Kennedy BK, Liu OW, Dick FA, Dyson N, Harlow E, Vidal M. Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8720-5. PMID: 11447271.
    Citations: 11     Fields:    Translation:AnimalsCells
  25. Lai A, Kennedy BK, Barbie DA, Bertos NR, Yang XJ, Theberge MC, Tsai SC, Seto E, Zhang Y, Kuzmichev A, Lane WS, Reinberg D, Harlow E, Branton PE. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. Mol Cell Biol. 2001 Apr; 21(8):2918-32. PMID: 11283269.
    Citations: 79     Fields:    Translation:HumansCells
  26. Stevenson LF, Kennedy BK, Harlow E. A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3946-51. PMID: 11274415.
    Citations: 42     Fields:    Translation:Animals
  27. Mihich E, Harlow E. Twelfth annual Pezcoller symposium: signaling cross-talks in cancer cells. Cancer Res. 2000 Dec 15; 60(24):7177-83. PMID: 11156428.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  28. Kennedy BK, Barbie DA, Classon M, Dyson N, Harlow E. Nuclear organization of DNA replication in primary mammalian cells. Genes Dev. 2000 Nov 15; 14(22):2855-68. PMID: 11090133.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  29. Classon M, Salama S, Gorka C, Mulloy R, Braun P, Harlow E. Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10820-5. PMID: 10995475.
    Citations: 45     Fields:    Translation:AnimalsCells
  30. Classon M, Kennedy BK, Mulloy R, Harlow E. Opposing roles of pRB and p107 in adipocyte differentiation. Proc Natl Acad Sci U S A. 2000 Sep 26; 97(20):10826-31. PMID: 10995476.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  31. Zhao J, Kennedy BK, Lawrence BD, Barbie DA, Matera AG, Fletcher JA, Harlow E. NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription. Genes Dev. 2000 Sep 15; 14(18):2283-97. PMID: 10995386.
    Citations: 130     Fields:    Translation:HumansCells
  32. McCaffrey J, Yamasaki L, Dyson NJ, Harlow E, Griep AE. Disruption of retinoblastoma protein family function by human papillomavirus type 16 E7 oncoprotein inhibits lens development in part through E2F-1. Mol Cell Biol. 1999 Sep; 19(9):6458-68. PMID: 10454591.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  33. Lukas ER, Bartley SM, Graveel CR, Diaz ZM, Dyson N, Harlow E, Yamasaki L, Farnham PJ. No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog. 1999 Aug; 25(4):295-303. PMID: 10449036.
    Citations: 7     Fields:    Translation:Animals
  34. Harrington EA, Bruce JL, Harlow E, Dyson N. pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11945-50. PMID: 9751770.
    Citations: 79     Fields:    Translation:AnimalsCells
  35. Schulman BA, Lindstrom DL, Harlow E. Substrate recruitment to cyclin-dependent kinase 2 by a multipurpose docking site on cyclin A. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10453-8. PMID: 9724724.
    Citations: 129     Fields:    Translation:Cells
  36. Pan H, Yin C, Dyson NJ, Harlow E, Yamasaki L, Van Dyke T. Key roles for E2F1 in signaling p53-dependent apoptosis and in cell division within developing tumors. Mol Cell. 1998 Sep; 2(3):283-92. PMID: 9774967.
    Citations: 53     Fields:    Translation:Animals
  37. Yamasaki L, Bronson R, Williams BO, Dyson NJ, Harlow E, Jacks T. Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice. Nat Genet. 1998 Apr; 18(4):360-4. PMID: 9537419.
    Citations: 86     Fields:    Translation:Animals
  38. Zhao J, Dynlacht B, Imai T, Hori T, Harlow E. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998 Feb 15; 12(4):456-61. PMID: 9472014.
    Citations: 61     Fields:    Translation:HumansCells
  39. Haber D, Harlow E. Tumour-suppressor genes: evolving definitions in the genomic age. Nat Genet. 1997 Aug; 16(4):320-2. PMID: 9241260.
    Citations: 23     Fields:    Translation:Humans
  40. Dynlacht BD, Moberg K, Lees JA, Harlow E, Zhu L. Specific regulation of E2F family members by cyclin-dependent kinases. Mol Cell Biol. 1997 Jul; 17(7):3867-75. PMID: 9199321.
    Citations: 33     Fields:    Translation:Cells
  41. LaBaer J, Garrett MD, Stevenson LF, Slingerland JM, Sandhu C, Chou HS, Fattaey A, Harlow E. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 1997 Apr 01; 11(7):847-62. PMID: 9106657.
    Citations: 349     Fields:    Translation:HumansCells
  42. Goillot E, Raingeaud J, Ranger A, Tepper RI, Davis RJ, Harlow E, Sanchez I. Mitogen-activated protein kinase-mediated Fas apoptotic signaling pathway. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3302-7. PMID: 9096388.
    Citations: 37     Fields:    Translation:HumansCells
  43. Zarkowska T, U S, Harlow E, Mittnacht S. Monoclonal antibodies specific for underphosphorylated retinoblastoma protein identify a cell cycle regulated phosphorylation site targeted by CDKs. Oncogene. 1997 Jan 16; 14(2):249-54. PMID: 9010227.
    Citations: 16     Fields:    Translation:Cells
  44. Dynlacht BD, Ngwu C, Winston J, Swindell EC, Elledge SJ, Harlow E, Harper JW. Purification and analysis of CIP/KIP proteins. Methods Enzymol. 1997; 283:230-44. PMID: 9251023.
    Citations: 6     Fields:    Translation:AnimalsCells
  45. Vidal M, Braun P, Chen E, Boeke JD, Harlow E. Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10321-6. PMID: 8816798.
    Citations: 47     Fields:    Translation:AnimalsCells
  46. Vidal M, Brachmann RK, Fattaey A, Harlow E, Boeke JD. Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10315-20. PMID: 8816797.
    Citations: 127     Fields:    Translation:AnimalsCells
  47. Harlow E. A research shortcut from a common cold virus to human cancer. Cancer. 1996 Aug 01; 78(3):558-65. PMID: 8697405.
    Citations:    Fields:    Translation:HumansAnimalsCells
  48. Magae J, Wu CL, Illenye S, Harlow E, Heintz NH. Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members. J Cell Sci. 1996 Jul; 109 ( Pt 7):1717-26. PMID: 8832394.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  49. Wu CL, Classon M, Dyson N, Harlow E. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol. 1996 Jul; 16(7):3698-706. PMID: 8668186.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  50. Cobrinik D, Lee MH, Hannon G, Mulligan G, Bronson RT, Dyson N, Harlow E, Beach D, Weinberg RA, Jacks T. Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 01; 10(13):1633-44. PMID: 8682294.
    Citations: 140     Fields:    Translation:AnimalsCells
  51. Zukerberg LR, Benedict WF, Arnold A, Dyson N, Harlow E, Harris NL. Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood. 1996 Jul 01; 88(1):268-76. PMID: 8704183.
    Citations: 6     Fields:    Translation:Cells
  52. Lee MH, Williams BO, Mulligan G, Mukai S, Bronson RT, Dyson N, Harlow E, Jacks T. Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 01; 10(13):1621-32. PMID: 8682293.
    Citations: 102     Fields:    Translation:AnimalsCells
  53. Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson NJ. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996 May 17; 85(4):537-48. PMID: 8653789.
    Citations: 190     Fields:    Translation:AnimalsCells
  54. Enders GH, Koh J, Missero C, Rustgi AK, Harlow E. p16 inhibition of transformed and primary squamous epithelial cells. Oncogene. 1996 Mar 21; 12(6):1239-45. PMID: 8649826.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  55. Zhu L, Harlow E, Dynlacht BD. p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F. Genes Dev. 1995 Jul 15; 9(14):1740-52. PMID: 7622038.
    Citations: 87     Fields:    Translation:HumansCells
  56. Koh J, Enders GH, Dynlacht BD, Harlow E. Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition. Nature. 1995 Jun 08; 375(6531):506-10. PMID: 7777061.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  57. Wu CL, Zukerberg LR, Ngwu C, Harlow E, Lees JA. In vivo association of E2F and DP family proteins. Mol Cell Biol. 1995 May; 15(5):2536-46. PMID: 7739537.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  58. Zhu L, Enders G, Lees JA, Beijersbergen RL, Bernards R, Harlow E. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J. 1995 May 01; 14(9):1904-13. PMID: 7743997.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  59. Wade M, Blake MC, Jambou RC, Helin K, Harlow E, Azizkhan JC. An inverted repeat motif stabilizes binding of E2F and enhances transcription of the dihydrofolate reductase gene. J Biol Chem. 1995 Apr 28; 270(17):9783-91. PMID: 7730357.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  60. Saito M, Helin K, Valentine MB, Griffith BB, Willman CL, Harlow E, Look AT. Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line. Genomics. 1995 Jan 01; 25(1):130-8. PMID: 7774910.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  61. Tsai LH, Delalle I, Caviness VS, Chae T, Harlow E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature. 1994 Sep 29; 371(6496):419-23. PMID: 8090221.
    Citations: 223     Fields:    Translation:HumansAnimalsCells
  62. Dynlacht BD, Flores O, Lees JA, Harlow E. Differential regulation of E2F transactivation by cyclin/cdk2 complexes. Genes Dev. 1994 Aug 01; 8(15):1772-86. PMID: 7958856.
    Citations: 119     Fields:    Translation:HumansCells
  63. Helin K, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein. J Virol. 1994 Aug; 68(8):5027-35. PMID: 8035503.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  64. Meyerson M, Harlow E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol. 1994 Mar; 14(3):2077-86. PMID: 8114739.
    Citations: 207     Fields:    Translation:HumansCells
  65. Mittnacht S, Lees JA, Desai D, Harlow E, Morgan DO, Weinberg RA. Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J. 1994 Jan 01; 13(1):118-27. PMID: 8306955.
    Citations: 39     Fields:    Translation:HumansCells
  66. Zhu L, Enders GH, Wu CL, Starz MA, Moberg KH, Lees JA, Dyson N, Harlow E. Growth suppression by members of the retinoblastoma protein family. Cold Spring Harb Symp Quant Biol. 1994; 59:75-84. PMID: 7587134.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  67. van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 1993 Dec 24; 262(5142):2050-4. PMID: 8266103.
    Citations: 335     Fields:    Translation:HumansCells
  68. Fattaey AR, Harlow E, Helin K. Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes. Mol Cell Biol. 1993 Dec; 13(12):7267-77. PMID: 8246949.
    Citations: 52     Fields:    Translation:HumansCells
  69. Tsai LH, Takahashi T, Caviness VS, Harlow E. Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system. Development. 1993 Dec; 119(4):1029-40. PMID: 8306873.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  70. Lees JA, Saito M, Vidal M, Valentine M, Look T, Harlow E, Dyson N, Helin K. The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol. 1993 Dec; 13(12):7813-25. PMID: 8246996.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  71. Fattaey AR, Helin K, Dembski MS, Dyson N, Harlow E, Vuocolo GA, Hanobik MG, Haskell KM, Oliff A, Defeo-Jones D, et al. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene. 1993 Nov; 8(11):3149-56. PMID: 8414517.
    Citations: 52     Fields:    Translation:HumansCells
  72. Helin K, Harlow E, Fattaey A. Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein. Mol Cell Biol. 1993 Oct; 13(10):6501-8. PMID: 8413249.
    Citations: 143     Fields:    Translation:HumansCells
  73. Helin K, Wu CL, Fattaey AR, Lees JA, Dynlacht BD, Ngwu C, Harlow E. Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation. Genes Dev. 1993 Oct; 7(10):1850-61. PMID: 8405995.
    Citations: 152     Fields:    Translation:HumansCells
  74. Zhu L, van den Heuvel S, Helin K, Fattaey A, Ewen M, Livingston D, Dyson N, Harlow E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev. 1993 Jul; 7(7A):1111-25. PMID: 8319904.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  75. Fattaey A, Helin K, Harlow E. Transcriptional inhibition by the retinoblastoma protein. Philos Trans R Soc Lond B Biol Sci. 1993 Jun 29; 340(1293):333-6. PMID: 8103936.
    Citations: 3     Fields:    Translation:AnimalsCells
  76. Tsai LH, Lees E, Faha B, Harlow E, Riabowol K. The cdk2 kinase is required for the G1-to-S transition in mammalian cells. Oncogene. 1993 Jun; 8(6):1593-602. PMID: 8502482.
    Citations: 91     Fields:    Translation:HumansCells
  77. Faha B, Harlow E, Lees E. The adenovirus E1A-associated kinase consists of cyclin E-p33cdk2 and cyclin A-p33cdk2. J Virol. 1993 May; 67(5):2456-65. PMID: 8386263.
    Citations: 27     Fields:    Translation:HumansCells
  78. Lees EM, Harlow E. Sequences within the conserved cyclin box of human cyclin A are sufficient for binding to and activation of cdc2 kinase. Mol Cell Biol. 1993 Feb; 13(2):1194-201. PMID: 8423786.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  79. Dyson N, Guida P, Münger K, Harlow E. Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol. 1992 Dec; 66(12):6893-902. PMID: 1331501.
    Citations: 133     Fields:    Translation:HumansCells
  80. Lees E, Faha B, Dulic V, Reed SI, Harlow E. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 1992 Oct; 6(10):1874-85. PMID: 1398067.
    Citations: 142     Fields:    Translation:HumansCells
  81. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH. A family of human cdc2-related protein kinases. EMBO J. 1992 Aug; 11(8):2909-17. PMID: 1639063.
    Citations: 200     Fields:    Translation:HumansAnimalsCells
  82. Helin K, Lees JA, Vidal M, Dyson N, Harlow E, Fattaey A. A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell. 1992 Jul 24; 70(2):337-50. PMID: 1638634.
    Citations: 211     Fields:    Translation:Cells
  83. Dyson N, Guida P, McCall C, Harlow E. Adenovirus E1A makes two distinct contacts with the retinoblastoma protein. J Virol. 1992 Jul; 66(7):4606-11. PMID: 1534854.
    Citations: 38     Fields:    Translation:Cells
  84. Harlow E. Eleventh annual Sapporo Cancer Seminar. Connecting the dots: assembling the pathways that control cell division. Cancer Res. 1992 Apr 15; 52(8):2362-6. PMID: 1559240.
    Citations:    Fields:    Translation:HumansAnimalsCells
  85. Hu QJ, Lees JA, Buchkovich KJ, Harlow E. The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol. 1992 Mar; 12(3):971-80. PMID: 1545827.
    Citations: 30     Fields:    Translation:HumansCells
  86. Cao L, Faha B, Dembski M, Tsai LH, Harlow E, Dyson N. Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature. 1992 Jan 09; 355(6356):176-9. PMID: 1530885.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  87. Ewen ME, Faha B, Harlow E, Livingston DM. Interaction of p107 with cyclin A independent of complex formation with viral oncoproteins. Science. 1992 Jan 03; 255(5040):85-7. PMID: 1532457.
    Citations: 80     Fields:    Translation:HumansCells
  88. Faha B, Ewen ME, Tsai LH, Livingston DM, Harlow E. Interaction between human cyclin A and adenovirus E1A-associated p107 protein. Science. 1992 Jan 03; 255(5040):87-90. PMID: 1532458.
    Citations: 65     Fields:    Translation:HumansCells
  89. Dyson N, Harlow E. Adenovirus E1A targets key regulators of cell proliferation. Cancer Surv. 1992; 12:161-95. PMID: 1353412.
    Citations: 67     Fields:    Translation:HumansCells
  90. Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E. The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J. 1991 Dec; 10(13):4279-90. PMID: 1756735.
    Citations: 109     Fields:    Translation:HumansCells
  91. Hu QJ, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol Cell Biol. 1991 Nov; 11(11):5792-9. PMID: 1717832.
    Citations: 49     Fields:    Translation:HumansAnimals
  92. Herrmann CH, Su LK, Harlow E. Adenovirus E1A is associated with a serine/threonine protein kinase. J Virol. 1991 Nov; 65(11):5848-59. PMID: 1833561.
    Citations: 21     Fields:    Translation:HumansCells
  93. Giordano A, Lee JH, Scheppler JA, Herrmann C, Harlow E, Deuschle U, Beach D, Franza BR. Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A. Science. 1991 Sep 13; 253(5025):1271-5. PMID: 1653969.
    Citations: 21     Fields:    Translation:HumansCells
  94. Tsai LH, Harlow E, Meyerson M. Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase. Nature. 1991 Sep 12; 353(6340):174-7. PMID: 1653904.
    Citations: 135     Fields:    Translation:HumansCells
  95. Larose A, Dyson N, Sullivan M, Harlow E, Bastin M. Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. J Virol. 1991 May; 65(5):2308-13. PMID: 2016761.
    Citations: 36     Fields:    Translation:AnimalsCells
  96. Meyerson M, Faha B, Su LK, Harlow E, Tsai LH. The cyclin-dependent kinase family. Cold Spring Harb Symp Quant Biol. 1991; 56:177-86. PMID: 1840251.
    Citations: 5     Fields:    Translation:HumansCells
  97. Lee CC, Craigen WJ, Muzny DM, Harlow E, Caskey CT. Cloning and expression of a mammalian peptide chain release factor with sequence similarity to tryptophanyl-tRNA synthetases. Proc Natl Acad Sci U S A. 1990 May; 87(9):3508-12. PMID: 2185472.
    Citations: 18     Fields:    Translation:AnimalsCells
  98. Hu QJ, Dyson N, Harlow E. The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J. 1990 Apr; 9(4):1147-55. PMID: 2138977.
    Citations: 89     Fields:    Translation:HumansCells
  99. Dyson N, Bernards R, Friend SH, Gooding LR, Hassell JA, Major EO, Pipas JM, Vandyke T, Harlow E. Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol. 1990 Mar; 64(3):1353-6. PMID: 2154613.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  100. Buchkovich K, Dyson N, Whyte P, Harlow E. Cellular proteins that are targets for transformation by DNA tumour viruses. Ciba Found Symp. 1990; 150:262-71; discussion 271-8. PMID: 2142644.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  101. Münger K, Werness BA, Dyson N, Phelps WC, Harlow E, Howley PM. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 1989 Dec 20; 8(13):4099-105. PMID: 2556261.
    Citations: 357     Fields:    Translation:HumansCells
  102. Buchkovich K, Duffy LA, Harlow E. The retinoblastoma protein is phosphorylated during specific phases of the cell cycle. Cell. 1989 Sep 22; 58(6):1097-105. PMID: 2673543.
    Citations: 260     Fields:    Translation:HumansCells
  103. Giordano A, Whyte P, Harlow E, Franza BR, Beach D, Draetta G. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell. 1989 Sep 08; 58(5):981-90. PMID: 2570639.
    Citations: 86     Fields:    Translation:HumansCells
  104. Dyson N, Buchkovich K, Whyte P, Harlow E. The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus. Cell. 1989 Jul 28; 58(2):249-55. PMID: 2546678.
    Citations: 110     Fields:    Translation:HumansCells
  105. Dyson N, Howley PM, Münger K, Harlow E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science. 1989 Feb 17; 243(4893):934-7. PMID: 2537532.
    Citations: 772     Fields:    Translation:HumansCells
  106. Horowitz JM, Yandell DW, Park SH, Canning S, Whyte P, Buchkovich K, Harlow E, Weinberg RA, Dryja TP. Point mutational inactivation of the retinoblastoma antioncogene. Science. 1989 Feb 17; 243(4893):937-40. PMID: 2521957.
    Citations: 98     Fields:    Translation:HumansCells
  107. Whyte P, Williamson NM, Harlow E. Cellular targets for transformation by the adenovirus E1A proteins. Cell. 1989 Jan 13; 56(1):67-75. PMID: 2521301.
    Citations: 293     Fields:    Translation:HumansCells
  108. Dyson N, Buchkovich K, Whyte P, Harlow E. Cellular proteins that are targetted by DNA tumor viruses for transformation. Princess Takamatsu Symp. 1989; 20:191-8. PMID: 2488232.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  109. Whyte P, Buchkovich KJ, Horowitz JM, Friend SH, Raybuck M, Weinberg RA, Harlow E. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature. 1988 Jul 14; 334(6178):124-9. PMID: 2968522.
    Citations: 421     Fields:    Translation:Humans
  110. Whyte P, Ruley HE, Harlow E. Two regions of the adenovirus early region 1A proteins are required for transformation. J Virol. 1988 Jan; 62(1):257-65. PMID: 2960834.
    Citations: 99     Fields:    Translation:AnimalsCells
  111. Horowitz JM, Friend SH, Weinberg RA, Whyte P, Buchkovich K, Harlow E. Anti-oncogenes and the negative regulation of cell growth. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 2:843-7. PMID: 2908198.
    Citations: 1     Fields:    Translation:HumansCells
  112. Stephens C, Harlow E. Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins. EMBO J. 1987 Jul; 6(7):2027-35. PMID: 2958276.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  113. Pallas DC, Schley C, Mahoney M, Harlow E, Schaffhausen BS, Roberts TM. Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production. J Virol. 1986 Dec; 60(3):1075-84. PMID: 3023660.
    Citations: 73     Fields:    Translation:Cells
  114. Harlow E, Whyte P, Franza BR, Schley C. Association of adenovirus early-region 1A proteins with cellular polypeptides. Mol Cell Biol. 1986 May; 6(5):1579-89. PMID: 2431282.
    Citations: 149     Fields:    Translation:HumansCells
  115. Harlow E, Williamson NM, Ralston R, Helfman DM, Adams TE. Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53. Mol Cell Biol. 1985 Jul; 5(7):1601-10. PMID: 3894933.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  116. Leppard K, Totty N, Waterfield M, Harlow E, Jenkins J, Crawford L. Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells. EMBO J. 1983; 2(11):1993-9. PMID: 6315411.
    Citations: 11     Fields:    Translation:Cells
  117. Crawford L, Leppard K, Lane D, Harlow E. Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen. J Virol. 1982 May; 42(2):612-20. PMID: 6177872.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  118. Harlow E, Pim DC, Crawford LV. Complex of simian virus 40 large-T antigen and host 53,000-molecular-weight protein in monkey cells. J Virol. 1981 Feb; 37(2):564-73. PMID: 6163871.
    Citations: 55     Fields:    Translation:AnimalsCells
  119. McCormick F, Harlow E. Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells. J Virol. 1980 Apr; 34(1):213-24. PMID: 6246255.
    Citations: 98     Fields:    Translation:AnimalsCells
  120. Crawford LV, Lane DP, Denhardt DT, Harlow EE, Nicklin PM, Osborn K, Pim DC. Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:179-87. PMID: 6253132.
    Citations: 9     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.