Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Veronique VanderHorst, M.D., Ph.D.

Other Positions

Available: 04/05/22, Expires: 06/01/23

1. Neurobiology of walking and circuit mechanisms underlying gait disorders. In mouse models, we study how walking, posture, and tone are controlled by forebrain-brainstem-spinal circuits using chemogenetic, optogenetic and in vivo calcium imaging tools. In parallel, in human postmortem brainstem and spinal cord we study clinical-pathological correlations relevant for gait abnormalities in neurodegenerative diseases. 2. Circuit modulation to improve movement disorders: We apply chemogenetic techniques to alleviate disease symptoms in movement disorders, such as Parkinson's disease, dystonia, gait disorders and sleep apnea in translational animal models. 3. Gait signatures in human subjects with neurological disease. We are developing an approach to quantify and characterize gait disorders in human subjects, which allows for translation to mouse models and can serve as an objective outcome measure in both clinical and pre-clinical studies.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Joshi K, Kirby A, Niu J, VanderHorst V. Stereotaxic Surgical Approach to Microinject the Caudal Brainstem and Upper Cervical Spinal Cord via the Cisterna Magna in Mice. J Vis Exp. 2022 01 21; (179). PMID: 35129178; PMCID: PMC9092805.
    Citations:    Fields:    Translation:Animals
  2. Buchman AS, Capuano AW, VanderHorst V, Wilson RS, Oveisgharan S, Schneider JA, Bennett DA. Brain ß-amyloid links the association of change in BMI with cognitive decline in community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2021 Oct 22. PMID: 34679171.
    Citations:    Fields:    
  3. Manor B, Dagan M, Herman T, Gouskova NA, Vanderhorst VG, Giladi N, Travison TG, Pascual-Leone A, Lipsitz LA, Hausdorff JM. Multitarget Transcranial Electrical Stimulation for Freezing of Gait: A Randomized Controlled Trial. Mov Disord. 2021 11; 36(11):2693-2698. PMID: 34406695.
    Citations: 5     Fields:    Translation:Humans
  4. Broom L, Stephen J, Nayar V, VanderHorst VG. Shifts in Gait Signatures Mark the End of Lifespan in Mice, With Sex Differences in Timing. Front Aging Neurosci. 2021; 13:716993. PMID: 34408647.
  5. Nag S, Yu L, VanderHorst VG, Schneider JA, Bennett DA, Buchman AS, Wilson RS. Neocortical Lewy bodies are associated with impaired odor identification in community-dwelling elders without clinical PD. J Neurol. 2019 Dec; 266(12):3108-3118. PMID: 31535271.
    Citations: 4     Fields:    Translation:HumansCells
  6. Verstegen AMJ, Klymko N, Zhu L, Mathai JC, Kobayashi R, Venner A, Ross RA, VanderHorst VG, Arrigoni E, Geerling JC, Zeidel ML. Non-Crh Glutamatergic Neurons in Barrington's Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus. Curr Biol. 2019 09 09; 29(17):2775-2789.e7. PMID: 31422881.
    Citations: 13     Fields:    Translation:AnimalsCells
  7. Broom L, Worley A, Gao F, Hernandez LD, Ashton CE, Shih LC, VanderHorst VG. Translational methods to detect asymmetries in temporal and spatial walking metrics in parkinsonian mouse models and human subjects with Parkinson's disease. Sci Rep. 2019 02 21; 9(1):2437. PMID: 30792396; PMCID: PMC6385183.
    Citations: 2     Fields:    Translation:HumansAnimals
  8. Buchman AS, Leurgans SE, VanderHorst VGJM, Nag S, Schneider JA, Bennett DA. Spinal motor neurons and motor function in older adults. J Neurol. 2019 Jan; 266(1):174-182. PMID: 30446967.
    Citations: 2     Fields:    Translation:HumansCells
  9. Buchman AS, Nag S, Leurgans SE, Miller J, VanderHorst VGJM, Bennett DA, Schneider JA. Spinal Lewy body pathology in older adults without an antemortem diagnosis of Parkinson's disease. Brain Pathol. 2018 07; 28(4):560-568. PMID: 28960595.
    Citations: 9     Fields:    Translation:Humans
  10. Buchman AS, Leurgans SE, Nag S, VanderHorst VGJM, Kapasi A, Schneider JA, Bennett DA. Spinal Arteriolosclerosis Is Common in Older Adults and Associated With Parkinsonism. Stroke. 2017 10; 48(10):2792-2798. PMID: 28931619.
    Citations: 11     Fields:    Translation:Humans
  11. Buchman NM, Leurgans SE, Shah RJ, VanderHorst V, Wilson RS, Bachner YG, Tanne D, Schneider JA, Bennett DA, Buchman AS. Urinary Incontinence, Incident Parkinsonism, and Parkinson's Disease Pathology in Older Adults. J Gerontol A Biol Sci Med Sci. 2017 Sep 01; 72(9):1295-1301. PMID: 27927762; PMCID: PMC6075180.
    Citations: 1     Fields:    Translation:Humans
  12. Broom L, Ellison BA, Worley A, Wagenaar L, Sörberg E, Ashton C, Bennett DA, Buchman AS, Saper CB, Shih LC, Hausdorff JM, VanderHorst VG. A translational approach to capture gait signatures of neurological disorders in mice and humans. Sci Rep. 2017 06 12; 7(1):3225. PMID: 28607434; PMCID: PMC5468293.
    Citations: 15     Fields:    Translation:HumansAnimals
  13. Gross C, Ellison B, Buchman AS, Terasawa E, VanderHorst VG. A novel approach for assigning levels to monkey and human lumbosacral spinal cord based on ventral horn morphology. PLoS One. 2017; 12(5):e0177243. PMID: 28542213.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  14. Verstegen AMJ, Vanderhorst V, Gray PA, Zeidel ML, Geerling JC. Barrington's nucleus: Neuroanatomic landscape of the mouse "pontine micturition center". J Comp Neurol. 2017 Jul 01; 525(10):2287-2309. PMID: 28340519; PMCID: PMC5832452.
    Citations: 26     Fields:    Translation:Animals
  15. Graebner AK, Tarsy D, Shih LC, Vanderhorst V, Kulkarni O, Kaplan S, Simon DK. Clinical Impact of 123I-Ioflupane SPECT (DaTscan) in a Movement Disorder Center. Neurodegener Dis. 2017; 17(1):38-43. PMID: 27614874.
    Citations: 5     Fields:    Translation:Humans
  16. Buchman AS, Yu L, Wilson RS, Dawe RJ, VanderHorst V, Schneider JA, Bennett DA. Post-mortem brain pathology is related to declining respiratory function in community-dwelling older adults. Front Aging Neurosci. 2015; 7:197. PMID: 26539108; PMCID: PMC4612667.
    Citations: 11     
  17. VanderHorst VG, Samardzic T, Saper CB, Anderson MP, Nag S, Schneider JA, Bennett DA, Buchman AS. a-Synuclein pathology accumulates in sacral spinal visceral sensory pathways. Ann Neurol. 2015 Jul; 78(1):142-9. PMID: 25893830; PMCID: PMC4480165.
    Citations: 21     Fields:    Translation:Humans
  18. Yokota S, Kaur S, VanderHorst VG, Saper CB, Chamberlin NL. Respiratory-related outputs of glutamatergic, hypercapnia-responsive parabrachial neurons in mice. J Comp Neurol. 2015 Apr 15; 523(6):907-20. PMID: 25424719; PMCID: PMC4329052.
    Citations: 35     Fields:    Translation:AnimalsCells
  19. Buchman AS, Leurgans SE, Weiss A, Vanderhorst V, Mirelman A, Dawe R, Barnes LL, Wilson RS, Hausdorff JM, Bennett DA. Associations between quantitative mobility measures derived from components of conventional mobility testing and Parkinsonian gait in older adults. PLoS One. 2014; 9(1):e86262. PMID: 24465997.
    Citations: 23     Fields:    Translation:Humans
  20. Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD. Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities. PLoS One. 2013; 8(3):e59032. PMID: 23516593.
    Citations: 9     Fields:    Translation:Animals
  21. Shih LC, Vanderhorst VG, Lozano AM, Hamani C, Moro E. Improvement of pisa syndrome with contralateral pedunculopontine stimulation. Mov Disord. 2013 Apr; 28(4):555-6. PMID: 23389993.
    Citations: 9     Fields:    Translation:Humans
  22. Buchman AS, Nag S, Shulman JM, Lim AS, VanderHorst VG, Leurgans SE, Schneider JA, Bennett DA. Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease. Mov Disord. 2012 Nov; 27(13):1625-31. PMID: 23038629.
    Citations: 25     Fields:    Translation:HumansCells
  23. Bruinstroop E, Cano G, Vanderhorst VG, Cavalcante JC, Wirth J, Sena-Esteves M, Saper CB. Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats. J Comp Neurol. 2012 Jun 15; 520(9):1985-2001. PMID: 22173709.
    Citations: 68     Fields:    Translation:AnimalsCells
  24. Shih LC, Piel J, Warren A, Kraics L, Silver A, Vanderhorst V, Simon DK, Tarsy D. Singing in groups for Parkinson's disease (SING-PD): a pilot study of group singing therapy for PD-related voice/speech disorders. Parkinsonism Relat Disord. 2012 Jun; 18(5):548-52. PMID: 22436653.
    Citations: 6     Fields:    Translation:Humans
  25. Shih LC, Vanderhorst V, Papavassiliou E, Tarsy D. Sustained dyskinesias following elective cessation and reactivation of chronic subthalamic nucleus deep brain stimulation for a surgical procedure. Neuromodulation. 2011 Nov-Dec; 14(6):512-4; discussion 514. PMID: 21854491.
    Citations:    Fields:    Translation:Humans
  26. Lungu C, Tarulli AW, Tarsy D, Mongiovi P, Vanderhorst VG, Rutkove SB. Quantifying muscle asymmetries in cervical dystonia with electrical impedance: a preliminary assessment. Clin Neurophysiol. 2011 May; 122(5):1027-31. PMID: 20943436.
    Citations: 3     Fields:    Translation:Humans
  27. Vanderhorst VG, Papavassiliou E, Tarsy D, Shih L. Early brain abscess: A rare complication of deep brain stimulation. Mov Disord. 2009 Jul 15; 24(9):1395-7. PMID: 19412938.
    Citations: 2     Fields:    Translation:Humans
  28. Vanderhorst VG, Terasawa E, Ralston HJ. Estrogen receptor-alpha immunoreactive neurons in the brainstem and spinal cord of the female rhesus monkey: species-specific characteristics. Neuroscience. 2009 Jan 23; 158(2):798-810. PMID: 18996446.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. VanderHorst VG, Ulfhake B. The organization of the brainstem and spinal cord of the mouse: relationships between monoaminergic, cholinergic, and spinal projection systems. J Chem Neuroanat. 2006 Jan; 31(1):2-36. PMID: 16183250.
    Citations: 46     Fields:    Translation:AnimalsCells
  30. Vanderhorst VG. Nucleus retroambiguus-spinal pathway in the mouse: Localization, gender differences, and effects of estrogen treatment. J Comp Neurol. 2005 Jul 25; 488(2):180-200. PMID: 15924340.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. Vanderhorst VG, Gustafsson JA, Ulfhake B. Estrogen receptor-alpha and -beta immunoreactive neurons in the brainstem and spinal cord of male and female mice: relationships to monoaminergic, cholinergic, and spinal projection systems. J Comp Neurol. 2005 Jul 25; 488(2):152-79. PMID: 15924341.
    Citations: 63     Fields:    Translation:AnimalsCells
  32. VanderHorst VG, Terasawa E, Ralston HJ. Projections from estrogen receptor-alpha immunoreactive neurons in the periaqueductal gray to the lateral medulla oblongata in the rhesus monkey. Neuroscience. 2004; 125(1):243-53. PMID: 15051163.
    Citations: 5     Fields:    Translation:AnimalsCells
  33. Vanderhorst VG, Terasawa E, Ralston HJ. Axonal sprouting of a brainstem-spinal pathway after estrogen administration in the adult female rhesus monkey. J Comp Neurol. 2002 Dec 02; 454(1):82-103. PMID: 12410620.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Yakovenko S, Mushahwar V, VanderHorst V, Holstege G, Prochazka A. Spatiotemporal activation of lumbosacral motoneurons in the locomotor step cycle. J Neurophysiol. 2002 Mar; 87(3):1542-53. PMID: 11877525.
    Citations: 57     Fields:    Translation:AnimalsCells
  35. Vanderhorst VG, Terasawa E, Ralston HJ. Estrogen receptor-alpha immunoreactive neurons in the ventrolateral periaqueductal gray receive monosynaptic input from the lumbosacral cord in the rhesus monkey. J Comp Neurol. 2002 Jan 28; 443(1):27-42. PMID: 11793345.
    Citations: 9     Fields:    Translation:AnimalsCells
  36. VanderHorst VG, Meijer E, Holstege G. Estrogen receptor-alpha immunoreactivity in parasympathetic preganglionic neurons innervating the bladder in the adult ovariectomized cat. Neurosci Lett. 2001 Feb 09; 298(3):147-50. PMID: 11165428.
    Citations: 8     Fields:    Translation:Animals
  37. VanderHorst VG, Terasawa E, Ralston HJ. Monosynaptic projections from the nucleus retroambiguus region to laryngeal motoneurons in the rhesus monkey. Neuroscience. 2001; 107(1):117-25. PMID: 11744252.
    Citations: 11     Fields:    Translation:AnimalsCells
  38. Vanderhorst VG, Terasawa E, Ralston HJ, Holstege G. Monosynaptic projections from the nucleus retroambiguus to motoneurons supplying the abdominal wall, axial, hindlimb, and pelvic floor muscles in the female rhesus monkey. J Comp Neurol. 2000 Aug 21; 424(2):233-50. PMID: 10906700.
    Citations: 19     Fields:    Translation:AnimalsCells
  39. Vanderhorst VG, Terasawa E, Ralston HJ, Holstege G. Monosynaptic projections from the lateral periaqueductal gray to the nucleus retroambiguus in the rhesus monkey: implications for vocalization and reproductive behavior. J Comp Neurol. 2000 Aug 21; 424(2):251-68. PMID: 10906701.
    Citations: 16     Fields:    Translation:AnimalsCells
  40. VanderHorst VG, Schasfoort FC, Meijer E, van Leeuwen FW, Holstege G. Estrogen receptor-alpha-immunoreactive neurons in the periaqueductal gray of the adult ovariectomized female cat. Neurosci Lett. 1998 Jan 02; 240(1):13-6. PMID: 9488163.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Mouton LJ, VanderHorst VG, Holstege G. Large segmental differences in the spinal projections to the periaqueductal gray in the cat. Neurosci Lett. 1997 Nov 28; 238(1-2):1-4. PMID: 9464640.
    Citations: 4     Fields:    Translation:Animals
  42. VanderHorst VG, Meijer E, Schasfoort FC, Van Leeuwen FW, Holstege G. Estrogen receptor-immunoreactive neurons in the lumbosacral cord projecting to the periaqueductal gray in the ovariectomized female cat. Neurosci Lett. 1997 Oct 24; 236(1):25-8. PMID: 9404943.
    Citations: 4     Fields:    Translation:AnimalsCells
  43. Holstege G, Kerstens L, Moes MC, Vanderhorst VG. Evidence for a periaqueductal gray-nucleus retroambiguus-spinal cord pathway in the rat. Neuroscience. 1997 Sep; 80(2):587-98. PMID: 9284360.
    Citations: 8     Fields:    Translation:Animals
  44. Vanderhorst VG, Holstege G. Organization of lumbosacral motoneuronal cell groups innervating hindlimb, pelvic floor, and axial muscles in the cat. J Comp Neurol. 1997 May 26; 382(1):46-76. PMID: 9136811.
    Citations: 74     Fields:    Translation:AnimalsCells
  45. Vanderhorst VG, Holstege G. Nucleus retroambiguus projections to lumbosacral motoneuronal cell groups in the male cat. J Comp Neurol. 1997 May 26; 382(1):77-88. PMID: 9136812.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. VanderHorst VG, de Weerd H, Holstege G. Evidence for monosynaptic projections from the nucleus retroambiguus to hindlimb motoneurons in the cat. Neurosci Lett. 1997 Mar 07; 224(1):33-6. PMID: 9132684.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. VanderHorst VG, Holstege G. Estrogen induces axonal outgrowth in the nucleus retroambiguus-lumbosacral motoneuronal pathway in the adult female cat. J Neurosci. 1997 Feb 01; 17(3):1122-36. PMID: 8994066; PMCID: PMC6573176.
    Citations: 10     Fields:    Translation:AnimalsCells
  48. Vanderhorst VG, Mouton LJ, Blok BF, Holstege G. Distinct cell groups in the lumbosacral cord of the cat project to different areas in the periaqueductal gray. J Comp Neurol. 1996 Dec 16; 376(3):361-85. PMID: 8956105.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  49. VanderHorst VG, Holstege G. A concept for the final common pathway of vocalization and lordosis behavior in the cat. Prog Brain Res. 1996; 107:327-42. PMID: 8782529.
    Citations: 9     Fields:    Translation:Animals
  50. Vanderhorst VG, Holstege G. Caudal medullary pathways to lumbosacral motoneuronal cell groups in the cat: evidence for direct projections possibly representing the final common pathway for lordosis. J Comp Neurol. 1995 Aug 28; 359(3):457-75. PMID: 7499541.
    Citations: 16     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
VanderHorst's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (222)
Co-Authors (19)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.