Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Dawn Lisa Demeo, M.D.

Co-Author

This page shows the publications co-authored by Dawn Demeo and Edwin Silverman.
Connection Strength

11.864
  1. Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet. 2009 Oct; 85(4):493-502.
    View in: PubMed
    Score: 0.419
  2. Heritability of lung function in severe alpha-1 antitrypsin deficiency. Hum Hered. 2009; 67(1):38-45.
    View in: PubMed
    Score: 0.392
  3. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. Am J Respir Cell Mol Biol. 2008 Jan; 38(1):114-20.
    View in: PubMed
    Score: 0.361
  4. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax. 2007 Sep; 62(9):806-13.
    View in: PubMed
    Score: 0.352
  5. Genetic determinants of emphysema distribution in the national emphysema treatment trial. Am J Respir Crit Care Med. 2007 Jul 01; 176(1):42-8.
    View in: PubMed
    Score: 0.351
  6. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):502.
    View in: PubMed
    Score: 0.336
  7. The SERPINE2 gene is associated with chronic obstructive pulmonary disease. Am J Hum Genet. 2006 Feb; 78(2):253-64.
    View in: PubMed
    Score: 0.322
  8. Concordance of genotypes in pre- and post-lung transplantation DNA samples. Am J Respir Cell Mol Biol. 2005 Oct; 33(4):402-5.
    View in: PubMed
    Score: 0.312
  9. Genome-wide linkage of forced mid-expiratory flow in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Dec 15; 170(12):1294-301.
    View in: PubMed
    Score: 0.294
  10. Familial aggregation of FEF(25-75) and FEF(25-75)/FVC in families with severe, early onset COPD. Thorax. 2004 May; 59(5):396-400.
    View in: PubMed
    Score: 0.288
  11. Alpha1-antitrypsin deficiency. 2: genetic aspects of alpha(1)-antitrypsin deficiency: phenotypes and genetic modifiers of emphysema risk. Thorax. 2004 Mar; 59(3):259-64.
    View in: PubMed
    Score: 0.284
  12. Genetics of chronic obstructive pulmonary disease. Semin Respir Crit Care Med. 2003 Apr; 24(2):151-60.
    View in: PubMed
    Score: 0.267
  13. Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease. Respir Res. 2022 Mar 24; 23(1):69.
    View in: PubMed
    Score: 0.248
  14. Optimism is associated with respiratory symptoms and functional status in chronic obstructive pulmonary disease. Respir Res. 2022 Jan 29; 23(1):19.
    View in: PubMed
    Score: 0.246
  15. Significant Spirometric Transitions and Preserved Ratio Impaired Spirometry Among Ever Smokers. Chest. 2022 Mar; 161(3):651-661.
    View in: PubMed
    Score: 0.240
  16. DNA methylation perturbations may link altered development and aging in the lung. Aging (Albany NY). 2021 01 19; 13(2):1742-1764.
    View in: PubMed
    Score: 0.229
  17. Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD. Eur Respir J. 2020 10; 56(4).
    View in: PubMed
    Score: 0.226
  18. Sex-specific associations with DNA methylation in lung tissue demonstrate smoking interactions. Epigenetics. 2021 06; 16(6):692-703.
    View in: PubMed
    Score: 0.224
  19. DNA Methylation Is Predictive of Mortality in Current and Former Smokers. Am J Respir Crit Care Med. 2020 05 01; 201(9):1099-1109.
    View in: PubMed
    Score: 0.218
  20. The Association of Multiparity with Lung Function and Chronic Obstructive Pulmonary Disease-Related Phenotypes. Chronic Obstr Pulm Dis. 2020 Apr; 7(2):86-98.
    View in: PubMed
    Score: 0.217
  21. Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Crit Care Med. 2019 09 15; 200(6):677-690.
    View in: PubMed
    Score: 0.209
  22. Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci. Am J Respir Crit Care Med. 2018 05 15; 197(10):1275-1284.
    View in: PubMed
    Score: 0.190
  23. DNA methylation profiling in human lung tissue identifies genes associated with COPD. Epigenetics. 2016 Oct 02; 11(10):730-739.
    View in: PubMed
    Score: 0.170
  24. Genome-wide site-specific differential methylation in the blood of individuals with Klinefelter syndrome. Mol Reprod Dev. 2015 May; 82(5):377-86.
    View in: PubMed
    Score: 0.154
  25. The impact of genetic variation and cigarette smoke on DNA methylation in current and former smokers from the COPDGene study. Epigenetics. 2015; 10(11):1064-73.
    View in: PubMed
    Score: 0.151
  26. Sexually-dimorphic targeting of functionally-related genes in COPD. BMC Syst Biol. 2014 Nov 28; 8:118.
    View in: PubMed
    Score: 0.150
  27. Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency. Respir Res. 2012 Feb 22; 13:16.
    View in: PubMed
    Score: 0.124
  28. Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD. 2011 Apr; 8(2):121-35.
    View in: PubMed
    Score: 0.116
  29. Association of SERPINE2 with asthma. Chest. 2011 Sep; 140(3):667-674.
    View in: PubMed
    Score: 0.116
  30. Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies. Thorax. 2011 Oct; 66(10):903-9.
    View in: PubMed
    Score: 0.114
  31. Clinical predictors of frequent exacerbations in subjects with severe chronic obstructive pulmonary disease (COPD). Respir Med. 2011 Apr; 105(4):588-94.
    View in: PubMed
    Score: 0.114
  32. Association of COPD candidate genes with computed tomography emphysema and airway phenotypes in severe COPD. Eur Respir J. 2011 Jan; 37(1):39-43.
    View in: PubMed
    Score: 0.110
  33. Gender differences in COPD: are women more susceptible to smoking effects than men? Thorax. 2010 Jun; 65(6):480-5.
    View in: PubMed
    Score: 0.110
  34. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. Am J Respir Crit Care Med. 2010 Sep 01; 182(5):605-13.
    View in: PubMed
    Score: 0.109
  35. Polymorphisms in surfactant protein-D are associated with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Mar; 44(3):316-22.
    View in: PubMed
    Score: 0.109
  36. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet. 2010 Mar; 42(3):200-2.
    View in: PubMed
    Score: 0.108
  37. Development of predictive models for airflow obstruction in alpha-1-antitrypsin deficiency. Am J Epidemiol. 2009 Oct 15; 170(8):1005-13.
    View in: PubMed
    Score: 0.104
  38. Genetic association analysis of COPD candidate genes with bronchodilator responsiveness. Respir Med. 2009 Apr; 103(4):552-7.
    View in: PubMed
    Score: 0.099
  39. Polymorphic variation in surfactant protein B is associated with COPD exacerbations. Eur Respir J. 2008 Oct; 32(4):938-44.
    View in: PubMed
    Score: 0.096
  40. National Emphysema Treatment Trial state of the art: genetics of emphysema. Proc Am Thorac Soc. 2008 May 01; 5(4):486-93.
    View in: PubMed
    Score: 0.095
  41. Clinical determinants of exacerbations in severe, early-onset COPD. Eur Respir J. 2007 Dec; 30(6):1124-30.
    View in: PubMed
    Score: 0.090
  42. Xenobiotic metabolizing enzyme gene polymorphisms predict response to lung volume reduction surgery. Respir Res. 2007 Aug 08; 8:59.
    View in: PubMed
    Score: 0.090
  43. Genetic linkage and association analysis of COPD-related traits on chromosome 8p. COPD. 2006 Dec; 3(4):189-94.
    View in: PubMed
    Score: 0.086
  44. Genetic determinants of functional impairment in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):476.
    View in: PubMed
    Score: 0.084
  45. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2006 May 01; 173(9):977-84.
    View in: PubMed
    Score: 0.081
  46. Attempted replication of reported chronic obstructive pulmonary disease candidate gene associations. Am J Respir Cell Mol Biol. 2005 Jul; 33(1):71-8.
    View in: PubMed
    Score: 0.077
  47. Smoke and mirrors: Mouse models as a reflection of human chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004 Nov 01; 170(9):929-31.
    View in: PubMed
    Score: 0.074
  48. Predictors of survival in severe, early onset COPD. Chest. 2004 Nov; 126(5):1443-51.
    View in: PubMed
    Score: 0.074
  49. The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet. 2004 Aug 01; 13(15):1649-56.
    View in: PubMed
    Score: 0.072
  50. Univariate and multivariate family-based association analysis of the IL-13 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol. 2002 Nov; 23(4):335-48.
    View in: PubMed
    Score: 0.065
  51. Interstitial lung abnormalities are associated with decreased mean telomere length. Eur Respir J. 2022 Feb 03.
    View in: PubMed
    Score: 0.062
  52. A Polygenic Risk Score and Age of Diagnosis of Chronic Obstructive Pulmonary Disease. Eur Respir J. 2022 Feb 03.
    View in: PubMed
    Score: 0.062
  53. Alpha-1 Antitrypsin MZ Heterozygosity Is an Endotype of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2022 02 01; 205(3):313-323.
    View in: PubMed
    Score: 0.062
  54. Whole-genome sequencing in diverse subjects identifies genetic correlates of leukocyte traits: The NHLBI TOPMed program. Am J Hum Genet. 2021 10 07; 108(10):1836-1851.
    View in: PubMed
    Score: 0.060
  55. Genetic variation in genes regulating skeletal muscle regeneration and tissue remodelling associated with weight loss in chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2021 12; 12(6):1803-1817.
    View in: PubMed
    Score: 0.060
  56. Secondary polycythemia in chronic obstructive pulmonary disease: prevalence and risk factors. BMC Pulm Med. 2021 Jul 14; 21(1):235.
    View in: PubMed
    Score: 0.059
  57. Genome-wide association analysis of COVID-19 mortality risk in SARS-CoV-2 genomes identifies mutation in the SARS-CoV-2 spike protein that colocalizes with P.1 of the Brazilian strain. Genet Epidemiol. 2021 10; 45(7):685-693.
    View in: PubMed
    Score: 0.059
  58. Epigenetics and pulmonary diseases in the horizon of precision medicine: a review. Eur Respir J. 2021 06; 57(6).
    View in: PubMed
    Score: 0.059
  59. Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD. Respir Res. 2021 Apr 27; 22(1):127.
    View in: PubMed
    Score: 0.058
  60. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 2021 02; 590(7845):290-299.
    View in: PubMed
    Score: 0.058
  61. A Risk Prediction Model for Mortality Among Smokers in the COPDGene® Study. Chronic Obstr Pulm Dis. 2020 Oct; 7(4):346-361.
    View in: PubMed
    Score: 0.056
  62. Somatotypes trajectories during adulthood and their association with COPD phenotypes. ERJ Open Res. 2020 Jul; 6(3).
    View in: PubMed
    Score: 0.056
  63. Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts. Lancet Respir Med. 2020 07; 8(7):696-708.
    View in: PubMed
    Score: 0.055
  64. COPDGene® 2019: Redefining the Diagnosis of Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2019 Nov; 6(5):384-399.
    View in: PubMed
    Score: 0.053
  65. Omics and the Search for Blood Biomarkers in Chronic Obstructive Pulmonary Disease. Insights from COPDGene. Am J Respir Cell Mol Biol. 2019 08; 61(2):143-149.
    View in: PubMed
    Score: 0.052
  66. Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 Jun; 51(6):1067.
    View in: PubMed
    Score: 0.051
  67. Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study. Chest. 2019 08; 156(2):228-238.
    View in: PubMed
    Score: 0.051
  68. Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls. Nicotine Tob Res. 2019 05 21; 21(6):714-722.
    View in: PubMed
    Score: 0.051
  69. RNA-sequencing across three matched tissues reveals shared and tissue-specific gene expression and pathway signatures of COPD. Respir Res. 2019 Apr 02; 20(1):65.
    View in: PubMed
    Score: 0.051
  70. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2019 04; 60(4):388-398.
    View in: PubMed
    Score: 0.051
  71. New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries. Nat Genet. 2019 03; 51(3):481-493.
    View in: PubMed
    Score: 0.050
  72. Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations. Nat Genet. 2019 03; 51(3):494-505.
    View in: PubMed
    Score: 0.050
  73. Longitudinal Phenotypes and Mortality in Preserved Ratio Impaired Spirometry in the COPDGene Study. Am J Respir Crit Care Med. 2018 12 01; 198(11):1397-1405.
    View in: PubMed
    Score: 0.049
  74. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics. 2018 01 15; 12(1):1.
    View in: PubMed
    Score: 0.046
  75. The value of blood cytokines and chemokines in assessing COPD. Respir Res. 2017 10 24; 18(1):180.
    View in: PubMed
    Score: 0.046
  76. Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest. 2018 01; 153(1):65-76.
    View in: PubMed
    Score: 0.045
  77. Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts. J Gen Intern Med. 2017 Dec; 32(12):1315-1322.
    View in: PubMed
    Score: 0.045
  78. Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups. Ann Am Thorac Soc. 2017 Aug; 14(8):1280-1287.
    View in: PubMed
    Score: 0.045
  79. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. Sci Rep. 2017 05 31; 7(1):2504.
    View in: PubMed
    Score: 0.044
  80. Genome-Wide Association Study of the Genetic Determinants of Emphysema Distribution. Am J Respir Crit Care Med. 2017 03 15; 195(6):757-771.
    View in: PubMed
    Score: 0.044
  81. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Sci Rep. 2017 03 13; 7:44232.
    View in: PubMed
    Score: 0.044
  82. Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. Am J Respir Cell Mol Biol. 2017 03; 56(3):332-341.
    View in: PubMed
    Score: 0.044
  83. Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet. 2016 Aug; 12(8):e1006011.
    View in: PubMed
    Score: 0.042
  84. Mitochondrial iron chelation ameliorates cigarette smoke-induced bronchitis and emphysema in mice. Nat Med. 2016 Feb; 22(2):163-74.
    View in: PubMed
    Score: 0.040
  85. A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry. BMC Genet. 2015 Dec 03; 16:138.
    View in: PubMed
    Score: 0.040
  86. Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J. 2016 Jan; 47(1):104-12.
    View in: PubMed
    Score: 0.040
  87. Clinical and Radiologic Disease in Smokers With Normal Spirometry. JAMA Intern Med. 2015 Sep; 175(9):1539-49.
    View in: PubMed
    Score: 0.039
  88. Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc. 2015 May; 12(5):648-56.
    View in: PubMed
    Score: 0.039
  89. A simplified score to quantify comorbidity in COPD. PLoS One. 2014; 9(12):e114438.
    View in: PubMed
    Score: 0.038
  90. Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. BMC Pulm Med. 2014 Oct 24; 14:164.
    View in: PubMed
    Score: 0.037
  91. Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. 2014 Oct; 146(4):941-950.
    View in: PubMed
    Score: 0.037
  92. Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med. 2014 Oct; 108(10):1469-80.
    View in: PubMed
    Score: 0.037
  93. Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res. 2014 Aug 06; 15:89.
    View in: PubMed
    Score: 0.037
  94. Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema. Thorax. 2014 May; 69(5):415-22.
    View in: PubMed
    Score: 0.035
  95. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med. 2014 Mar; 2(3):214-25.
    View in: PubMed
    Score: 0.035
  96. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013; 8(2):e56179.
    View in: PubMed
    Score: 0.033
  97. Racial differences in CT phenotypes in COPD. COPD. 2013 Feb; 10(1):20-7.
    View in: PubMed
    Score: 0.033
  98. Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach. Biostatistics. 2012 Jul; 13(3):468-81.
    View in: PubMed
    Score: 0.030
  99. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet. 2012 Feb 15; 21(4):947-57.
    View in: PubMed
    Score: 0.030
  100. Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):414-20.
    View in: PubMed
    Score: 0.030
  101. Peripheral blood gene expression profiles in COPD subjects. J Clin Bioinforma. 2011 Apr 24; 1(1):12.
    View in: PubMed
    Score: 0.029
  102. Combining disease models to test for gene-environment interaction in nuclear families. Biometrics. 2011 Dec; 67(4):1260-70.
    View in: PubMed
    Score: 0.029
  103. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):304-10.
    View in: PubMed
    Score: 0.028
  104. Polymorphisms in the superoxide dismutase-3 gene are associated with emphysema in COPD. COPD. 2010 Aug; 7(4):262-8.
    View in: PubMed
    Score: 0.028
  105. MMP12, lung function, and COPD in high-risk populations. N Engl J Med. 2009 Dec 31; 361(27):2599-608.
    View in: PubMed
    Score: 0.027
  106. Parsing the effects of individual SNPs in candidate genes with family data. Hum Hered. 2010; 69(2):91-103.
    View in: PubMed
    Score: 0.026
  107. Associations of IL6 polymorphisms with lung function decline and COPD. Thorax. 2009 Aug; 64(8):698-704.
    View in: PubMed
    Score: 0.025
  108. Molecular biomarkers for quantitative and discrete COPD phenotypes. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):359-67.
    View in: PubMed
    Score: 0.024
  109. Testing and estimating gene-environment interactions in family-based association studies. Biometrics. 2008 Jun; 64(2):458-67.
    View in: PubMed
    Score: 0.023
  110. Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood. J Allergy Clin Immunol. 2007 Jul; 120(1):84-90.
    View in: PubMed
    Score: 0.022
  111. Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genes. Proc Am Thorac Soc. 2006 Aug; 3(6):472.
    View in: PubMed
    Score: 0.021
  112. Genomic screening and replication using the same data set in family-based association testing. Nat Genet. 2005 Jul; 37(7):683-91.
    View in: PubMed
    Score: 0.019
  113. A family-based association test for repeatedly measured quantitative traits adjusting for unknown environmental and/or polygenic effects. Stat Appl Genet Mol Biol. 2004; 3:Article17.
    View in: PubMed
    Score: 0.018
  114. PBAT: tools for family-based association studies. Am J Hum Genet. 2004 Feb; 74(2):367-9.
    View in: PubMed
    Score: 0.018
  115. Using the noninformative families in family-based association tests: a powerful new testing strategy. Am J Hum Genet. 2003 Oct; 73(4):801-11.
    View in: PubMed
    Score: 0.017
  116. A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. Hum Hered. 2003; 56(1-3):10-7.
    View in: PubMed
    Score: 0.016
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.