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Vamsi Krishna Mootha, M.D.

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Department
Address
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Other Positions
Title
Institution
Department

Mentoring
Understanding Molecular Events Elicited by Mitochondrial Complex I Loss and Hypoxia
Summer, 06/01/18 - 08/31/18
An integrated approach to the genetic diagnosis of mitochondrial disorders
Summer, 06/13/11 - 08/08/11
Reconstruction of the Mammalian Coenzyme Q Biosynthetic Pathway
Summer, 06/20/05 - 08/12/05
Characterizing the Effects of WFS1 Disruption on Protein Interactions and Mitochondrial Function
Summer, 05/24/10 - 09/01/10

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR071942 (GRABAREK, ZENON) Sep 1, 2018 - Jul 31, 2023
    NIH
    Structure, function, and disease biology of MICU1/MICU2
    Role: Co-Principal Investigator
  2. R35GM122455 (MOOTHA, VAMSI KRISHNA) May 29, 2017 - Apr 30, 2022
    NIH
    Mitochondrial Parts, Pathways, and Pathogenesis
    Role: Principal Investigator
  3. R01HL130143 (CHOU, JAMES JEIWEN) Feb 1, 2017 - Jan 31, 2021
    NIH
    Molecular Architecture Of The Mitochondrial Calcium Uniporter
    Role: Co-Principal Investigator
  4. R01GM099683 (MOOTHA, VAMSI KRISHNA) Sep 30, 2011 - Aug 31, 2016
    NIH
    Molecular prostheses for mitochondrial disorders
    Role: Principal Investigator
  5. R01GM097136 (MOOTHA, VAMSI KRISHNA) Jun 15, 2011 - Feb 29, 2016
    NIH
    Human Mitochondrial Disease: From Novel Gene Variants to Causality and Function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Laricchia KM, Lake NJ, Watts NA, Shand M, Haessly A, Gauthier L, Benjamin D, Banks E, Soto J, Garimella K, Emery J, Rehm HL, MacArthur DG, Tiao G, Lek M, Mootha VK, Calvo SE. Mitochondrial DNA variation across 56,434 individuals in gnomAD. Genome Res. 2022 03; 32(3):569-582. PMID: 35074858.
    Citations:    Fields:    Translation:HumansCells
  2. Wang Z, Guo R, Trudeau SJ, Wolinsky E, Ast T, Liang JH, Jiang C, Ma Y, Teng M, Mootha VK, Gewurz BE. CYB561A3 is the key lysosomal iron reductase required for Burkitt B-cell growth and survival. Blood. 2021 12 02; 138(22):2216-2230. PMID: 34232987.
    Citations: 3     Fields:    Translation:HumansCells
  3. Walker MA, Miranda M, Allred A, Mootha VK. On the dynamic and even reversible nature of Leigh syndrome: Lessons from human imaging and mouse models. Curr Opin Neurobiol. 2022 02; 72:80-90. PMID: 34656053.
    Citations: 1     Fields:    
  4. Gupta R, Karczewski KJ, Howrigan D, Neale BM, Mootha VK. Human genetic analyses of organelles highlight the nucleus in age-related trait heritability. Elife. 2021 09 01; 10. PMID: 34467851.
    Citations: 1     Fields:    Translation:HumansCells
  5. Vishnu N, Hamilton A, Bagge A, Wernersson A, Cowan E, Barnard H, Sancak Y, Kamer KJ, Spégel P, Fex M, Tengholm A, Mootha VK, Nicholls DG, Mulder H. Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion. Mol Metab. 2021 09; 51:101239. PMID: 33932586.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Jourdain AA, Begg BE, Mick E, Shah H, Calvo SE, Skinner OS, Sharma R, Blue SM, Yeo GW, Burge CB, Mootha VK. Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS. Mol Cell. 2021 05 06; 81(9):1905-1919.e12. PMID: 33852893.
    Citations: 3     Fields:    Translation:HumansCells
  7. Zhang Y, Guo R, Kim SH, Shah H, Zhang S, Liang JH, Fang Y, Gentili M, Leary CNO, Elledge SJ, Hung DT, Mootha VK, Gewurz BE. SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication. Nat Commun. 2021 03 15; 12(1):1676. PMID: 33723254.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  8. Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome. Mol Genet Metab. 2021 05; 133(1):83-93. PMID: 33752971.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Chinnery PF, Falk MJ, Mootha VK, Rahman S. Editorial: Mitochondrial medicine special issue. J Inherit Metab Dis. 2021 03; 44(2):289-291. PMID: 33764554.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Sharma R, Reinstadler B, Engelstad K, Skinner OS, Stackowitz E, Haller RG, Clish CB, Pierce K, Walker MA, Fryer R, Oglesbee D, Mao X, Shungu DC, Khatri A, Hirano M, De Vivo DC, Mootha VK. Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity. J Clin Invest. 2021 01 19; 131(2). PMID: 33463549.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  11. Rath S, Sharma R, Gupta R, Ast T, Chan C, Durham TJ, Goodman RP, Grabarek Z, Haas ME, Hung WHW, Joshi PR, Jourdain AA, Kim SH, Kotrys AV, Lam SS, McCoy JG, Meisel JD, Miranda M, Panda A, Patgiri A, Rogers R, Sadre S, Shah H, Skinner OS, To TL, Walker MA, Wang H, Ward PS, Wengrod J, Yuan CC, Calvo SE, Mootha VK. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 2021 01 08; 49(D1):D1541-D1547. PMID: 33174596.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  12. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57. PMID: 33384370.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  13. Hathazi D, Griffin H, Jennings MJ, Giunta M, Powell C, Pearce SF, Munro B, Wei W, Boczonadi V, Poulton J, Pyle A, Calabrese C, Gomez-Duran A, Schara U, Pitceathly RDS, Hanna MG, Joost K, Cotta A, Paim JF, Navarro MM, Duff J, Mattman A, Chapman K, Servidei S, Della Marina A, Uusimaa J, Roos A, Mootha V, Hirano M, Tulinius M, Giri M, Hoffmann EP, Lochmüller H, DiMauro S, Minczuk M, Chinnery PF, Müller JS, Horvath R. Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency. EMBO J. 2020 12 01; 39(23):e105364. PMID: 33128823.
    Citations: 4     Fields:    Translation:HumansCells
  14. Walker MA, Lareau CA, Ludwig LS, Karaa A, Sankaran VG, Regev A, Mootha VK. Purifying Selection against Pathogenic Mitochondrial DNA in Human T Cells. N Engl J Med. 2020 10 15; 383(16):1556-1563. PMID: 32786181.
    Citations: 9     Fields:    Translation:HumansCells
  15. Wang Y, Han Y, She J, Nguyen NX, Mootha VK, Bai XC, Jiang Y. Structural insights into the Ca2+-dependent gating of the human mitochondrial calcium uniporter. Elife. 2020 08 07; 9. PMID: 32762847.
    Citations: 13     Fields:    Translation:HumansCells
  16. MacEwen MJ, Markhard AL, Bozbeyoglu M, Bradford F, Goldberger O, Mootha VK, Sancak Y. Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU. Life Sci Alliance. 2020 10; 3(10). PMID: 32769116.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Frazier AE, Compton AG, Kishita Y, Hock DH, Welch AE, Amarasekera SSC, Rius R, Formosa LE, Imai-Okazaki A, Francis D, Wang M, Lake NJ, Tregoning S, Jabbari JS, Lucattini A, Nitta KR, Ohtake A, Murayama K, Amor DJ, McGillivray G, Wong FY, van der Knaap MS, Jeroen Vermeulen R, Wiltshire EJ, Fletcher JM, Lewis B, Baynam G, Ellaway C, Balasubramaniam S, Bhattacharya K, Freckmann ML, Arbuckle S, Rodriguez M, Taft RJ, Sadedin S, Cowley MJ, Minoche AE, Calvo SE, Mootha VK, Ryan MT, Okazaki Y, Stroud DA, Simons C, Christodoulou J, Thorburn DR. Fatal perinatal mitochondrial cardiac failure caused by recurrent de novo duplications in the ATAD3 locus. Med (N Y). 2021 Jan 15; 2(1):49-73. PMID: 33575671.
    Citations: 7     
  18. Mok BY, de Moraes MH, Zeng J, Bosch DE, Kotrys AV, Raguram A, Hsu F, Radey MC, Peterson SB, Mootha VK, Mougous JD, Liu DR. A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature. 2020 07; 583(7817):631-637. PMID: 32641830.
    Citations: 100     Fields:    Translation:HumansCells
  19. Ghosh S, Basu Ball W, Madaris TR, Srikantan S, Madesh M, Mootha VK, Gohil VM. An essential role for cardiolipin in the stability and function of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16383-16390. PMID: 32601238.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  20. Mick E, Titov DV, Skinner OS, Sharma R, Jourdain AA, Mootha VK. Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell. Elife. 2020 05 28; 9. PMID: 32463360.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  21. Goodman RP, Markhard AL, Shah H, Sharma R, Skinner OS, Clish CB, Deik A, Patgiri A, Hsu YH, Masia R, Noh HL, Suk S, Goldberger O, Hirschhorn JN, Yellen G, Kim JK, Mootha VK. Hepatic NADH reductive stress underlies common variation in metabolic traits. Nature. 2020 07; 583(7814):122-126. PMID: 32461692.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  22. Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK. Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem. 2020 Apr 17; 295(16):5533. PMID: 33509593.
    Citations:    Fields:    
  23. Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK. Correction: Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem. 2020 Apr 17; 295(16):5533. PMID: 32303645.
    Citations:    Fields:    
  24. Jain IH, Calvo SE, Markhard AL, Skinner OS, To TL, Ast T, Mootha VK. Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism. Cell. 2020 04 30; 181(3):716-727.e11. PMID: 32259488.
    Citations: 36     Fields:    Translation:HumansCells
  25. Patgiri A, Skinner OS, Miyazaki Y, Schleifer G, Marutani E, Shah H, Sharma R, Goodman RP, To TL, Robert Bao X, Ichinose F, Zapol WM, Mootha VK. An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance. Nat Biotechnol. 2020 03; 38(3):309-313. PMID: 31932725.
    Citations: 21     Fields:    Translation:HumansCells
  26. To TL, Cuadros AM, Shah H, Hung WHW, Li Y, Kim SH, Rubin DHF, Boe RH, Rath S, Eaton JK, Piccioni F, Goodale A, Kalani Z, Doench JG, Root DE, Schreiber SL, Vafai SB, Mootha VK. A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering. Cell. 2019 11 14; 179(5):1222-1238.e17. PMID: 31730859.
    Citations: 33     Fields:    Translation:HumansCells
  27. Ruetz M, Campanello GC, Purchal M, Shen H, McDevitt L, Gouda H, Wakabayashi S, Zhu J, Rubin EJ, Warncke K, Mootha VK, Koutmos M, Banerjee R. Itaconyl-CoA forms a stable biradical in methylmalonyl-CoA mutase and derails its activity and repair. Science. 2019 11 01; 366(6465):589-593. PMID: 31672889.
    Citations: 17     Fields:    Translation:HumansCells
  28. Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies. Cancer Cell. 2019 10 14; 36(4):369-384.e13. PMID: 31543463.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  29. Ast T, Mootha VK. Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox? Nat Metab. 2019 09; 1(9):858-860. PMID: 32694740.
    Citations: 23     Fields:    Translation:Animals
  30. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3. PMID: 31402314.
    Citations: 27     Fields:    Translation:Animals
  31. Hung V, Lam SS, Udeshi ND, Svinkina T, Guzman G, Mootha VK, Carr SA, Ting AY. Correction: Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation. Elife. 2019 Aug 05; 8. PMID: 31378216.
    Citations: 1     Fields:    
  32. Wang LW, Shen H, Nobre L, Ersing I, Paulo JA, Trudeau S, Wang Z, Smith NA, Ma Y, Reinstadler B, Nomburg J, Sommermann T, Cahir-McFarland E, Gygi SP, Mootha VK, Weekes MP, Gewurz BE. Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation. Cell Metab. 2019 09 03; 30(3):539-555.e11. PMID: 31257153.
    Citations: 36     Fields:    Translation:HumansCells
  33. Flicker D, Sancak Y, Mick E, Goldberger O, Mootha VK. Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics. Cell Rep. 2019 04 30; 27(5):1364-1375.e5. PMID: 31042465.
    Citations: 10     Fields:    Translation:AnimalsCells
  34. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019 05 30; 177(6):1507-1521.e16. PMID: 31031004.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  35. Lake NJ, Formosa LE, Stroud DA, Ryan MT, Calvo SE, Mootha VK, Morar B, Procopis PG, Christodoulou J, Compton AG, Thorburn DR. A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant. Hum Mutat. 2019 07; 40(7):893-898. PMID: 30981218.
    Citations: 2     Fields:    Translation:HumansCells
  36. Kamer KJ, Jiang W, Kaushik VK, Mootha VK, Grabarek Z. Crystal structure of MICU2 and comparison with MICU1 reveal insights into the uniporter gating mechanism. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3546-3555. PMID: 30755530.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  37. Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome. Am J Physiol Lung Cell Mol Physiol. 2019 02 01; 316(2):L391-L399. PMID: 30520688.
    Citations: 2     Fields:    Translation:AnimalsCells
  38. Gray MW, Mootha VK. Evolutionary mitochondrial biology in titisee. IUBMB Life. 2018 12; 70(12):1184-1187. PMID: 30358089.
    Citations:    Fields:    Translation:HumansCells
  39. Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y. Author Correction: Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature. 2018 10; 562(7728):E25. PMID: 30108362.
    Citations:    Fields:    
  40. Gopal RK, Kübler K, Calvo SE, Polak P, Livitz D, Rosebrock D, Sadow PM, Campbell B, Donovan SE, Amin S, Gigliotti BJ, Grabarek Z, Hess JM, Stewart C, Braunstein LZ, Arndt PF, Mordecai S, Shih AR, Chaves F, Zhan T, Lubitz CC, Kim J, Iafrate AJ, Wirth L, Parangi S, Leshchiner I, Daniels GH, Mootha VK, Dias-Santagata D, Getz G, McFadden DG. Widespread Chromosomal Losses and Mitochondrial DNA Alterations as Genetic Drivers in Hürthle Cell Carcinoma. Cancer Cell. 2018 08 13; 34(2):242-255.e5. PMID: 30107175.
    Citations: 52     Fields:    Translation:Humans
  41. Kamer KJ, Sancak Y, Fomina Y, Meisel JD, Chaudhuri D, Grabarek Z, Mootha VK. MICU1 imparts the mitochondrial uniporter with the ability to discriminate between Ca2+ and Mn2+. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E7960-E7969. PMID: 30082385.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  42. Nguyen NX, Armache JP, Lee C, Yang Y, Zeng W, Mootha VK, Cheng Y, Bai XC, Jiang Y. Cryo-EM structure of a fungal mitochondrial calcium uniporter. Nature. 2018 07; 559(7715):570-574. PMID: 29995855.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  43. Gopal RK, Calvo SE, Shih AR, Chaves FL, McGuone D, Mick E, Pierce KA, Li Y, Garofalo A, Van Allen EM, Clish CB, Oliva E, Mootha VK. Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):E6283-E6290. PMID: 29915083.
    Citations: 28     Fields:    Translation:HumansCells
  44. Mootha VK, Chinnery PF. Oxygen in mitochondrial disease: can there be too much of a good thing? J Inherit Metab Dis. 2018 09; 41(5):761-763. PMID: 29948481.
    Citations: 4     Fields:    Translation:Humans
  45. Musa S, Eyaid W, Kamer K, Ali R, Al-Mureikhi M, Shahbeck N, Al Mesaifri F, Makhseed N, Mohamed Z, AlShehhi WA, Mootha VK, Juusola J, Ben-Omran T. A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients. JIMD Rep. 2019; 43:79-83. PMID: 29721912.
    Citations: 24     
  46. Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. Am J Hum Genet. 2018 04 05; 102(4):713. PMID: 29625026.
    Citations: 6     Fields:    
  47. Goodman RP, Calvo SE, Mootha VK. Spatiotemporal compartmentalization of hepatic NADH and NADPH metabolism. J Biol Chem. 2018 05 18; 293(20):7508-7516. PMID: 29514978.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  48. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 02 14; 14(3):206-214. PMID: 29443976.
    Citations: 164     Fields:    Translation:HumansCells
  49. Siegmund SE, Yang H, Sharma R, Javors M, Skinner O, Mootha V, Hirano M, Schon EA. Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome. Hum Mol Genet. 2017 12 01; 26(23):4588-4605. PMID: 28973153.
    Citations: 34     Fields:    Translation:AnimalsCells
  50. Garone C, D'Souza AR, Dallabona C, Lodi T, Rebelo-Guiomar P, Rorbach J, Donati MA, Procopio E, Montomoli M, Guerrini R, Zeviani M, Calvo SE, Mootha VK, DiMauro S, Ferrero I, Minczuk M. Defective mitochondrial rRNA methyltransferase MRM2 causes MELAS-like clinical syndrome. Hum Mol Genet. 2017 11 01; 26(21):4257-4266. PMID: 28973171.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  51. Shen H, Campanello GC, Flicker D, Grabarek Z, Hu J, Luo C, Banerjee R, Mootha VK. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12. Cell. 2017 Nov 02; 171(4):771-782.e11. PMID: 29056341.
    Citations: 35     Fields:    Translation:HumansCells
  52. Udeshi ND, Pedram K, Svinkina T, Fereshetian S, Myers SA, Aygun O, Krug K, Clauser K, Ryan D, Ast T, Mootha VK, Ting AY, Carr SA. Antibodies to biotin enable large-scale detection of biotinylation sites on proteins. Nat Methods. 2017 Dec; 14(12):1167-1170. PMID: 29039416.
    Citations: 38     Fields:    Translation:HumansCells
  53. Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9096-E9104. PMID: 29073106.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  54. Feichtinger RG, Oláhová M, Kishita Y, Garone C, Kremer LS, Yagi M, Uchiumi T, Jourdain AA, Thompson K, D'Souza AR, Kopajtich R, Alston CL, Koch J, Sperl W, Mastantuono E, Strom TM, Wortmann SB, Meitinger T, Pierre G, Chinnery PF, Chrzanowska-Lightowlers ZM, Lightowlers RN, DiMauro S, Calvo SE, Mootha VK, Moggio M, Sciacco M, Comi GP, Ronchi D, Murayama K, Ohtake A, Rebelo-Guiomar P, Kohda M, Kang D, Mayr JA, Taylor RW, Okazaki Y, Minczuk M, Prokisch H. Biallelic C1QBP Mutations Cause Severe Neonatal-, Childhood-, or Later-Onset Cardiomyopathy Associated with Combined Respiratory-Chain Deficiencies. Am J Hum Genet. 2017 Oct 05; 101(4):525-538. PMID: 28942965.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  55. Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK. A genetically encoded tool for manipulation of NADP+/NADPH in living cells. Nat Chem Biol. 2017 Oct; 13(10):1088-1095. PMID: 28805804.
    Citations: 24     Fields:    Translation:HumansCells
  56. Lake NJ, Webb BD, Stroud DA, Richman TR, Ruzzenente B, Compton AG, Mountford HS, Pulman J, Zangarelli C, Rio M, Boddaert N, Assouline Z, Sherpa MD, Schadt EE, Houten SM, Byrnes J, McCormick EM, Zolkipli-Cunningham Z, Haude K, Zhang Z, Retterer K, Bai R, Calvo SE, Mootha VK, Christodoulou J, Rötig A, Filipovska A, Cristian I, Falk MJ, Metodiev MD, Thorburn DR. Biallelic Mutations in MRPS34 Lead to Instability of the Small Mitoribosomal Subunit and Leigh Syndrome. Am J Hum Genet. 2017 Aug 03; 101(2):239-254. PMID: 28777931.
    Citations: 38     Fields:    Translation:HumansCells
  57. Li Y, Jourdain AA, Calvo SE, Liu JS, Mootha VK. CLIC, a tool for expanding biological pathways based on co-expression across thousands of datasets. PLoS Comput Biol. 2017 Jul; 13(7):e1005653. PMID: 28719601.
    Citations: 14     Fields:    Translation:HumansCells
  58. Delaney NF, Sharma R, Tadvalkar L, Clish CB, Haller RG, Mootha VK. Metabolic profiles of exercise in patients with McArdle disease or mitochondrial myopathy. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8402-8407. PMID: 28716914.
    Citations: 18     Fields:    Translation:HumansCells
  59. Kamer KJ, Grabarek Z, Mootha VK. High-affinity cooperative Ca2+ binding by MICU1-MICU2 serves as an on-off switch for the uniporter. EMBO Rep. 2017 08; 18(8):1397-1411. PMID: 28615291.
    Citations: 65     Fields:    Translation:HumansCells
  60. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. PMID: 28483998.
    Citations: 52     Fields:    Translation:AnimalsCells
  61. Hung V, Lam SS, Udeshi ND, Svinkina T, Guzman G, Mootha VK, Carr SA, Ting AY. Proteomic mapping of cytosol-facing outer mitochondrial and ER membranes in living human cells by proximity biotinylation. Elife. 2017 04 25; 6. PMID: 28441135.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  62. Calvo SE, Julien O, Clauser KR, Shen H, Kamer KJ, Wells JA, Mootha VK. Comparative Analysis of Mitochondrial N-Termini from Mouse, Human, and Yeast. Mol Cell Proteomics. 2017 04; 16(4):512-523. PMID: 28122942.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  63. Arroyo JD, Jourdain AA, Calvo SE, Ballarano CA, Doench JG, Root DE, Mootha VK. A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. Cell Metab. 2016 12 13; 24(6):875-885. PMID: 27667664.
    Citations: 92     Fields:    Translation:HumansCells
  64. Vafai SB, Mevers E, Higgins KW, Fomina Y, Zhang J, Mandinova A, Newman D, Shaw SY, Clardy J, Mootha VK. Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors. PLoS One. 2016; 11(9):e0162686. PMID: 27622560.
    Citations: 10     Fields:    Translation:AnimalsCells
  65. Perales-Clemente E, Cook AN, Evans JM, Roellinger S, Secreto F, Emmanuele V, Oglesbee D, Mootha VK, Hirano M, Schon EA, Terzic A, Nelson TJ. Natural underlying mtDNA heteroplasmy as a potential source of intra-person hiPSC variability. EMBO J. 2016 09 15; 35(18):1979-90. PMID: 27436875.
    Citations: 30     Fields:    Translation:HumansCells
  66. Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife. 2016 06 16; 5. PMID: 27307216.
    Citations: 138     Fields:    Translation:HumansCells
  67. Oxenoid K, Dong Y, Cao C, Cui T, Sancak Y, Markhard AL, Grabarek Z, Kong L, Liu Z, Ouyang B, Cong Y, Mootha VK, Chou JJ. Architecture of the mitochondrial calcium uniporter. Nature. 2016 05 12; 533(7602):269-73. PMID: 27135929.
    Citations: 106     Fields:    Translation:AnimalsCells
  68. Titov DV, Cracan V, Goodman RP, Peng J, Grabarek Z, Mootha VK. Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio. Science. 2016 Apr 08; 352(6282):231-5. PMID: 27124460.
    Citations: 91     Fields:    Translation:HumansCells
  69. Lewis-Smith D, Kamer KJ, Griffin H, Childs AM, Pysden K, Titov D, Duff J, Pyle A, Taylor RW, Yu-Wai-Man P, Ramesh V, Horvath R, Mootha VK, Chinnery PF. Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood. Neurol Genet. 2016 Apr; 2(2):e59. PMID: 27123478.
    Citations: 45     
  70. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. PMID: 26917594.
    Citations: 158     Fields:    Translation:HumansAnimalsCells
  71. Rietman A, Stanley TL, Clish C, Mootha V, Mensink M, Grinspoon SK, Makimura H. Associations between plasma branched-chain amino acids, ß-aminoisobutyric acid and body composition. J Nutr Sci. 2016; 5:e6. PMID: 27313851.
    Citations: 15     Fields:    
  72. Chen H, Ren S, Clish C, Jain M, Mootha V, McCaffery JM, Chan DC. Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. J Cell Biol. 2015 Nov 23; 211(4):795-805. PMID: 26598616.
    Citations: 58     Fields:    Translation:AnimalsCells
  73. Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ, Vachon L, Morin C, Laprise C, Rioux JD, Mootha VK, Des Rosiers C. A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome Cell Rep. 2015 11 03; 13(5):981-9. PMID: 26565911.
    Citations: 48     Fields:    Translation:HumansCells
  74. Calvo SE, Clauser KR, Mootha VK. MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins. Nucleic Acids Res. 2016 Jan 04; 44(D1):D1251-7. PMID: 26450961.
    Citations: 573     Fields:    Translation:HumansAnimals
  75. Kamer KJ, Mootha VK. The molecular era of the mitochondrial calcium uniporter. Nat Rev Mol Cell Biol. 2015 Sep; 16(9):545-53. PMID: 26285678.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  76. Kishi S, Campanholle G, Gohil VM, Perocchi F, Brooks CR, Morizane R, Sabbisetti V, Ichimura T, Mootha VK, Bonventre JV. Meclizine Preconditioning Protects the Kidney Against Ischemia-Reperfusion Injury. EBioMedicine. 2015 Sep; 2(9):1090-101. PMID: 26501107.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  77. Fassone E, Duncan AJ, Taanman JW, Pagnamenta AT, Sadowski MI, Holand T, Qasim W, Rutland P, Calvo SE, Mootha VK, Bitner-Glindzicz M, Rahman S. FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. Hum Mol Genet. 2015 Jul 15; 24(14):4183. PMID: 26022995.
    Citations: 3     Fields:    
  78. Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab. 2015 Apr 07; 21(4):609-21. PMID: 25863250.
    Citations: 64     Fields:    Translation:AnimalsCells
  79. Lam SS, Martell JD, Kamer KJ, Deerinck TJ, Ellisman MH, Mootha VK, Ting AY. Directed evolution of APEX2 for electron microscopy and proximity labeling. Nat Methods. 2015 Jan; 12(1):51-4. PMID: 25419960.
    Citations: 364     Fields:    Translation:HumansAnimalsCells
  80. Lennerz BS, Vafai SB, Delaney NF, Clish CB, Deik AA, Pierce KA, Ludwig DS, Mootha VK. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Mol Genet Metab. 2015 Jan; 114(1):73-9. PMID: 25497115.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  81. Sinha A, Köhrer C, Weber MH, Masuda I, Mootha VK, Hou YM, RajBhandary UL. Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase. J Biol Chem. 2014 Nov 21; 289(47):32729-41. PMID: 25288793.
    Citations: 9     Fields:    Translation:HumansCells
  82. Ajroud-Driss S, Fecto F, Ajroud K, Lalani I, Calvo SE, Mootha VK, Deng HX, Siddique N, Tahmoush AJ, Heiman-Patterson TD, Siddique T. Mutation in the novel nuclear-encoded mitochondrial protein CHCHD10 in a family with autosomal dominant mitochondrial myopathy. Neurogenetics. 2015 Jan; 16(1):1-9. PMID: 25193783.
    Citations: 43     Fields:    Translation:HumansCells
  83. Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY. Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol Cell. 2014 Jul 17; 55(2):332-41. PMID: 25002142.
    Citations: 179     Fields:    Translation:HumansCells
  84. Li Y, Calvo SE, Gutman R, Liu JS, Mootha VK. Expansion of biological pathways based on evolutionary inference. Cell. 2014 Jul 03; 158(1):213-25. PMID: 24995987.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  85. Kovács-Bogdán E, Sancak Y, Kamer KJ, Plovanich M, Jambhekar A, Huber RJ, Myre MA, Blower MD, Mootha VK. Reconstitution of the mitochondrial calcium uniporter in yeast. Proc Natl Acad Sci U S A. 2014 Jun 17; 111(24):8985-90. PMID: 24889638.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  86. Kamer KJ, Sancak Y, Mootha VK. The uniporter: from newly identified parts to function. Biochem Biophys Res Commun. 2014 Jul 11; 449(4):370-2. PMID: 24814702.
    Citations: 15     Fields:    Translation:HumansCells
  87. Wolf AR, Mootha VK. Functional genomic analysis of human mitochondrial RNA processing. Cell Rep. 2014 May 08; 7(3):918-31. PMID: 24746820.
    Citations: 42     Fields:    Translation:HumansCells
  88. Lieber DS, Hershman SG, Slate NG, Calvo SE, Sims KB, Schmahmann JD, Mootha VK. Next generation sequencing with copy number variant detection expands the phenotypic spectrum of HSD17B4-deficiency. BMC Med Genet. 2014 Mar 06; 15:30. PMID: 24602372.
    Citations: 22     Fields:    Translation:HumansCells
  89. Jain M, Ngoy S, Sheth SA, Swanson RA, Rhee EP, Liao R, Clish CB, Mootha VK, Nilsson R. A systematic survey of lipids across mouse tissues. Am J Physiol Endocrinol Metab. 2014 Apr 15; 306(8):E854-68. PMID: 24518676.
    Citations: 32     Fields:    Translation:Animals
  90. Kamer KJ, Mootha VK. MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. EMBO Rep. 2014 Mar; 15(3):299-307. PMID: 24503055.
    Citations: 111     Fields:    Translation:HumansCells
  91. Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer. Nat Commun. 2014; 5:3128. PMID: 24451681.
    Citations: 218     Fields:    Translation:HumansCells
  92. Vafai SB, Mootha VK. Medicine. A common pathway for a rare disease? Science. 2013 Dec 20; 342(6165):1453-4. PMID: 24357304.
    Citations: 16     Fields:    Translation:Animals
  93. Strittmatter L, Li Y, Nakatsuka NJ, Calvo SE, Grabarek Z, Mootha VK. CLYBL is a polymorphic human enzyme with malate synthase and ß-methylmalate synthase activity. Hum Mol Genet. 2014 May 01; 23(9):2313-23. PMID: 24334609.
    Citations: 17     Fields:    Translation:Humans
  94. Sancak Y, Markhard AL, Kitami T, Kovács-Bogdán E, Kamer KJ, Udeshi ND, Carr SA, Chaudhuri D, Clapham DE, Li AA, Calvo SE, Goldberger O, Mootha VK. EMRE is an essential component of the mitochondrial calcium uniporter complex. Science. 2013 Dec 13; 342(6164):1379-82. PMID: 24231807.
    Citations: 287     Fields:    Translation:HumansCells
  95. Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J Biol Chem. 2013 Dec 06; 288(49):35387-95. PMID: 24142790.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  96. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 07; 93(5):906-14. PMID: 24119684.
    Citations: 25     Fields:    Translation:HumansAnimals
  97. Chakravarti A, Clark AG, Mootha VK. Distilling pathophysiology from complex disease genetics. Cell. 2013 Sep 26; 155(1):21-6. PMID: 24074858.
    Citations: 42     Fields:    Translation:HumansAnimals
  98. Garone C, Donati MA, Sacchini M, Garcia-Diaz B, Bruno C, Calvo S, Mootha VK, Dimauro S. Mitochondrial encephalomyopathy due to a novel mutation in ACAD9. JAMA Neurol. 2013 Sep 01; 70(9):1177-9. PMID: 23836383.
    Citations: 16     Fields:    Translation:HumansCells
  99. Pfeffer G, Horvath R, Klopstock T, Mootha VK, Suomalainen A, Koene S, Hirano M, Zeviani M, Bindoff LA, Yu-Wai-Man P, Hanna M, Carelli V, McFarland R, Majamaa K, Turnbull DM, Smeitink J, Chinnery PF. New treatments for mitochondrial disease-no time to drop our standards. Nat Rev Neurol. 2013 Aug; 9(8):474-81. PMID: 23817350.
    Citations: 76     Fields:    Translation:Humans
  100. Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkühler S, Thorburn DR, Compton AG. Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes. Hum Mol Genet. 2013 Nov 15; 22(22):4460-73. PMID: 23814038.
    Citations: 48     Fields:    Translation:HumansCells
  101. Csordás G, Golenár T, Seifert EL, Kamer KJ, Sancak Y, Perocchi F, Moffat C, Weaver D, Perez SF, Bogorad R, Koteliansky V, Adijanto J, Mootha VK, Hajnóczky G. MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²? uniporter. Cell Metab. 2013 Jun 04; 17(6):976-987. PMID: 23747253.
    Citations: 232     Fields:    Translation:HumansAnimalsCells
  102. Chaudhuri D, Sancak Y, Mootha VK, Clapham DE. MCU encodes the pore conducting mitochondrial calcium currents. Elife. 2013 Jun 04; 2:e00704. PMID: 23755363.
    Citations: 90     Fields:    Translation:HumansCells
  103. Singh N, Mootha VK, Madan K, Aggarwal AN, Behera D. Tumor cavitation among lung cancer patients receiving first-line chemotherapy at a tertiary care centre in India: association with histology and overall survival. Med Oncol. 2013; 30(3):602. PMID: 23673987.
    Citations: 8     Fields:    Translation:Humans
  104. Lieber DS, Calvo SE, Shanahan K, Slate NG, Liu S, Hershman SG, Gold NB, Chapman BA, Thorburn DR, Berry GT, Schmahmann JD, Borowsky ML, Mueller DM, Sims KB, Mootha VK. Targeted exome sequencing of suspected mitochondrial disorders. Neurology. 2013 May 07; 80(19):1762-70. PMID: 23596069.
    Citations: 70     Fields:    Translation:HumansCells
  105. Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013; 8(2):e55785. PMID: 23409044.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  106. Rhee HW, Zou P, Udeshi ND, Martell JD, Mootha VK, Carr SA, Ting AY. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science. 2013 Mar 15; 339(6125):1328-1331. PMID: 23371551.
    Citations: 411     Fields:    Translation:HumansAnimalsCells
  107. Kornblum C, Nicholls TJ, Haack TB, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, Quinzii CM, DiMauro S, Calvo SE, Mootha VK, Klopstock T, Strom TM, Meitinger T, Minczuk M, Kunz WS, Prokisch H. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nat Genet. 2013 Feb; 45(2):214-9. PMID: 23313956.
    Citations: 93     Fields:    Translation:HumansCells
  108. Rensvold JW, Ong SE, Jeevananthan A, Carr SA, Mootha VK, Pagliarini DJ. Complementary RNA and protein profiling identifies iron as a key regulator of mitochondrial biogenesis. Cell Rep. 2013 Jan 31; 3(1):237-45. PMID: 23318259.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  109. Garone C, Rubio JC, Calvo SE, Naini A, Tanji K, Dimauro S, Mootha VK, Hirano M. MPV17 Mutations Causing Adult-Onset Multisystemic Disorder With Multiple Mitochondrial DNA Deletions. Arch Neurol. 2012 Dec; 69(12):1648-51. PMID: 22964873.
    Citations: 25     Fields:    
  110. Vafai SB, Mootha VK. Mitochondrial disorders as windows into an ancient organelle. Nature. 2012 Nov 15; 491(7424):374-83. PMID: 23151580.
    Citations: 268     Fields:    Translation:HumansCells
  111. Martell JD, Deerinck TJ, Sancak Y, Poulos TL, Mootha VK, Sosinsky GE, Ellisman MH, Ting AY. Engineered ascorbate peroxidase as a genetically encoded reporter for electron microscopy. Nat Biotechnol. 2012 Nov; 30(11):1143-8. PMID: 23086203.
    Citations: 251     Fields:    
  112. Ronchi D, Garone C, Bordoni A, Gutierrez Rios P, Calvo SE, Ripolone M, Ranieri M, Rizzuti M, Villa L, Magri F, Corti S, Bresolin N, Mootha VK, Moggio M, DiMauro S, Comi GP, Sciacco M. Next-generation sequencing reveals DGUOK mutations in adult patients with mitochondrial DNA multiple deletions. Brain. 2012 Nov; 135(Pt 11):3404-15. PMID: 23043144.
    Citations: 38     Fields:    Translation:HumansCells
  113. Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver P, Griffin PR, Clapham DE, Spiegelman BM. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 2012 Sep 28; 151(1):96-110. PMID: 23021218.
    Citations: 143     Fields:    Translation:AnimalsCells
  114. McCormack SE, Shaham O, McCarthy MA, Deik AA, Wang TJ, Gerszten RE, Clish CB, Mootha VK, Grinspoon SK, Fleischman A. Circulating branched-chain amino acid concentrations are associated with obesity and future insulin resistance in children and adolescents. Pediatr Obes. 2013 Feb; 8(1):52-61. PMID: 22961720.
    Citations: 168     Fields:    Translation:Humans
  115. Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25; 336(6084):1040-4. PMID: 22628656.
    Citations: 577     Fields:    Translation:HumansCells
  116. Bick AG, Calvo SE, Mootha VK. Evolutionary diversity of the mitochondrial calcium uniporter. Science. 2012 May 18; 336(6083):886. PMID: 22605770.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  117. Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK. A chemical screen probing the relationship between mitochondrial content and cell size. PLoS One. 2012; 7(3):e33755. PMID: 22479437.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  118. Calvo SE, Compton AG, Hershman SG, Lim SC, Lieber DS, Tucker EJ, Laskowski A, Garone C, Liu S, Jaffe DB, Christodoulou J, Fletcher JM, Bruno DL, Goldblatt J, Dimauro S, Thorburn DR, Mootha VK. Molecular diagnosis of infantile mitochondrial disease with targeted next-generation sequencing. Sci Transl Med. 2012 Jan 25; 4(118):118ra10. PMID: 22277967.
    Citations: 197     Fields:    Translation:HumansCells
  119. Lieber DS, Vafai SB, Horton LC, Slate NG, Liu S, Borowsky ML, Calvo SE, Schmahmann JD, Mootha VK. Atypical case of Wolfram syndrome revealed through targeted exome sequencing in a patient with suspected mitochondrial disease. BMC Med Genet. 2012 Jan 06; 13:3. PMID: 22226368.
    Citations: 14     Fields:    Translation:Humans
  120. Leoni V, Strittmatter L, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab. 2012 Mar; 105(3):463-71. PMID: 22221393.
    Citations: 42     Fields:    Translation:HumansCells
  121. Tucker EJ, Hershman SG, Köhrer C, Belcher-Timme CA, Patel J, Goldberger OA, Christodoulou J, Silberstein JM, McKenzie M, Ryan MT, Compton AG, Jaffe JD, Carr SA, Calvo SE, RajBhandary UL, Thorburn DR, Mootha VK. Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation. Cell Metab. 2011 Sep 07; 14(3):428-34. PMID: 21907147.
    Citations: 68     Fields:    Translation:HumansCells
  122. Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. ACS Chem Biol. 2011 Sep 16; 6(9):900-4. PMID: 21732624.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  123. Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011 Jun 19; 476(7360):341-5. PMID: 21685886.
    Citations: 784     Fields:    Translation:HumansAnimalsCells
  124. Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, O'Donnell CJ, Carr SA, Mootha VK, Florez JC, Souza A, Melander O, Clish CB, Gerszten RE. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011 Apr; 17(4):448-53. PMID: 21423183.
    Citations: 1187     Fields:    Translation:Humans
  125. Mootha VK, Agarwal R, Singh N, Aggarwal AN, Gupta D, Jindal SK. Medical thoracoscopy for undiagnosed pleural effusions: experience from a tertiary care hospital in north India. Indian J Chest Dis Allied Sci. 2011 Jan-Mar; 53(1):21-4. PMID: 21446220.
    Citations: 13     Fields:    Translation:Humans
  126. Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15; 20(2):294-300. PMID: 20977989.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  127. Fassone E, Duncan AJ, Taanman JW, Pagnamenta AT, Sadowski MI, Holand T, Qasim W, Rutland P, Calvo SE, Mootha VK, Bitner-Glindzicz M, Rahman S. FOXRED1, encoding an FAD-dependent oxidoreductase complex-I-specific molecular chaperone, is mutated in infantile-onset mitochondrial encephalopathy. Hum Mol Genet. 2010 Dec 15; 19(24):4837-47. PMID: 20858599.
    Citations: 37     Fields:    Translation:HumansCells
  128. Calvo SE, Tucker EJ, Compton AG, Kirby DM, Crawford G, Burtt NP, Rivas M, Guiducci C, Bruno DL, Goldberger OA, Redman MC, Wiltshire E, Wilson CJ, Altshuler D, Gabriel SB, Daly MJ, Thorburn DR, Mootha VK. High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency. Nat Genet. 2010 Oct; 42(10):851-8. PMID: 20818383.
    Citations: 152     Fields:    Translation:Humans
  129. Segrè AV, Groop L, Mootha VK, Daly MJ, Altshuler D. Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. PLoS Genet. 2010 Aug 12; 6(8). PMID: 20714348.
    Citations: 278     Fields:    
  130. Perocchi F, Gohil VM, Girgis HS, Bao XR, McCombs JE, Palmer AE, Mootha VK. MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake. Nature. 2010 Sep 16; 467(7313):291-6. PMID: 20693986.
    Citations: 397     Fields:    Translation:HumansCells
  131. Gohil VM, Nilsson R, Belcher-Timme CA, Luo B, Root DE, Mootha VK. Mitochondrial and nuclear genomic responses to loss of LRPPRC expression. J Biol Chem. 2010 Apr 30; 285(18):13742-7. PMID: 20220140.
    Citations: 48     Fields:    Translation:HumansCells
  132. Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J. Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses. Am Heart J. 2010 Mar; 159(3):428-33. PMID: 20211305.
    Citations: 2     Fields:    Translation:Humans
  133. Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Giguère V. The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions. Genes Dev. 2010 Mar 15; 24(6):537-42. PMID: 20194433.
    Citations: 71     Fields:    Translation:AnimalsCells
  134. Gohil VM, Sheth SA, Nilsson R, Wojtovich AP, Lee JH, Perocchi F, Chen W, Clish CB, Ayata C, Brookes PS, Mootha VK. Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis. Nat Biotechnol. 2010 Mar; 28(3):249-55. PMID: 20160716.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
  135. Mootha VK, Hirschhorn JN. Inborn variation in metabolism. Nat Genet. 2010 Feb; 42(2):97-8. PMID: 20104246.
    Citations: 9     Fields:    Translation:Humans
  136. Shaham O, Slate NG, Goldberger O, Xu Q, Ramanathan A, Souza AL, Clish CB, Sims KB, Mootha VK. A plasma signature of human mitochondrial disease revealed through metabolic profiling of spent media from cultured muscle cells. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1571-5. PMID: 20080599.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  137. Calvo SE, Mootha VK. The mitochondrial proteome and human disease. Annu Rev Genomics Hum Genet. 2010; 11:25-44. PMID: 20690818.
    Citations: 228     Fields:    Translation:HumansCells
  138. Gupta D, Mootha VK. Neuraminidase inhibitors for influenza in healthy adults: what we don't know. Natl Med J India. 2010 Jan-Feb; 23(1):29-31. PMID: 20839590.
    Citations: 1     Fields:    Translation:Humans
  139. Baughman JM, Nilsson R, Gohil VM, Arlow DH, Gauhar Z, Mootha VK. A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis. PLoS Genet. 2009 Aug; 5(8):e1000590. PMID: 19680543.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  140. Nilsson R, Schultz IJ, Pierce EL, Soltis KA, Naranuntarat A, Ward DM, Baughman JM, Paradkar PN, Kingsley PD, Culotta VC, Kaplan J, Palis J, Paw BH, Mootha VK. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab. 2009 Aug; 10(2):119-30. PMID: 19656490.
    Citations: 96     Fields:    Translation:AnimalsCells
  141. Calvo SE, Pagliarini DJ, Mootha VK. Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7507-12. PMID: 19372376.
    Citations: 380     Fields:    Translation:HumansCells
  142. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Tasan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE. Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. J Clin Invest. 2008 Oct; 118(10):3503-12. PMID: 18769631.
    Citations: 110     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  143. Sugiana C, Pagliarini DJ, McKenzie M, Kirby DM, Salemi R, Abu-Amero KK, Dahl HH, Hutchison WM, Vascotto KA, Smith SM, Newbold RF, Christodoulou J, Calvo S, Mootha VK, Ryan MT, Thorburn DR. Mutation of C20orf7 disrupts complex I assembly and causes lethal neonatal mitochondrial disease. Am J Hum Genet. 2008 Oct; 83(4):468-78. PMID: 18940309.
    Citations: 78     Fields:    Translation:HumansCells
  144. Shaham O, Wei R, Wang TJ, Ricciardi C, Lewis GD, Vasan RS, Carr SA, Thadhani R, Gerszten RE, Mootha VK. Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity. Mol Syst Biol. 2008; 4:214. PMID: 18682704.
    Citations: 168     Fields:    Translation:HumansCells
  145. Pagliarini DJ, Calvo SE, Chang B, Sheth SA, Vafai SB, Ong SE, Walford GA, Sugiana C, Boneh A, Chen WK, Hill DE, Vidal M, Evans JG, Thorburn DR, Carr SA, Mootha VK. A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11; 134(1):112-23. PMID: 18614015.
    Citations: 874     Fields:    Translation:HumansAnimalsCells
  146. Mootha V. Vamsi Mootha: taking an inventory of mitochondria. Interview by Hema Bashyam. J Exp Med. 2008 Jun 09; 205(6):1248-9. PMID: 18541715.
    Citations: 1     Fields:    Translation:Cells
  147. Wagner BK, Kitami T, Gilbert TJ, Peck D, Ramanathan A, Schreiber SL, Golub TR, Mootha VK. Large-scale chemical dissection of mitochondrial function. Nat Biotechnol. 2008 Mar; 26(3):343-51. PMID: 18297058.
    Citations: 87     Fields:    Translation:AnimalsCells
  148. Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007 Nov 29; 450(7170):736-40. PMID: 18046414.
    Citations: 623     Fields:    Translation:AnimalsCells
  149. Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest. 2007 Nov; 117(11):3463-74. PMID: 17932564.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  150. Parikh H, Carlsson E, Chutkow WA, Johansson LE, Storgaard H, Poulsen P, Saxena R, Ladd C, Schulze PC, Mazzini MJ, Jensen CB, Krook A, Björnholm M, Tornqvist H, Zierath JR, Ridderstråle M, Altshuler D, Lee RT, Vaag A, Groop LC, Mootha VK. TXNIP regulates peripheral glucose metabolism in humans. PLoS Med. 2007 May; 4(5):e158. PMID: 17472435.
    Citations: 210     Fields:    Translation:HumansAnimalsCells
  151. Baughman JM, Mootha VK. Buffering mitochondrial DNA variation. Nat Genet. 2006 Nov; 38(11):1232-3. PMID: 17072298.
    Citations: 4     Fields:    Translation:HumansAnimals
  152. Saxena R, de Bakker PI, Singer K, Mootha V, Burtt N, Hirschhorn JN, Gaudet D, Isomaa B, Daly MJ, Groop L, Ardlie KG, Altshuler D. Comprehensive association testing of common mitochondrial DNA variation in metabolic disease. Am J Hum Genet. 2006 Jul; 79(1):54-61. PMID: 16773565.
    Citations: 96     Fields:    Translation:Humans
  153. Foster LJ, de Hoog CL, Zhang Y, Zhang Y, Xie X, Mootha VK, Mann M. A mammalian organelle map by protein correlation profiling. Cell. 2006 Apr 07; 125(1):187-99. PMID: 16615899.
    Citations: 203     Fields:    Translation:AnimalsCells
  154. Spinazzola A, Viscomi C, Fernandez-Vizarra E, Carrara F, D'Adamo P, Calvo S, Marsano RM, Donnini C, Weiher H, Strisciuglio P, Parini R, Sarzi E, Chan A, DiMauro S, Rötig A, Gasparini P, Ferrero I, Mootha VK, Tiranti V, Zeviani M. MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion. Nat Genet. 2006 May; 38(5):570-5. PMID: 16582910.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  155. Calvo S, Jain M, Xie X, Sheth SA, Chang B, Goldberger OA, Spinazzola A, Zeviani M, Carr SA, Mootha VK. Systematic identification of human mitochondrial disease genes through integrative genomics. Nat Genet. 2006 May; 38(5):576-82. PMID: 16582907.
    Citations: 138     Fields:    Translation:HumansCells
  156. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15545-50. PMID: 16199517.
    Citations: 17129     Fields:    Translation:HumansCells
  157. Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, Yialamas M, Groop L, Elahi D, Hayes FJ. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care. 2005 Jul; 28(7):1636-42. PMID: 15983313.
    Citations: 107     Fields:    Translation:HumansCells
  158. Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M. Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals. Nature. 2005 Mar 17; 434(7031):338-45. PMID: 15735639.
    Citations: 883     Fields:    Translation:HumansAnimalsCells
  159. Quinzii CM, Kattah AG, Naini A, Akman HO, Mootha VK, DiMauro S, Hirano M. Coenzyme Q deficiency and cerebellar ataxia associated with an aprataxin mutation. Neurology. 2005 Feb 08; 64(3):539-41. PMID: 15699391.
    Citations: 67     Fields:    Translation:HumansCells
  160. Giallourakis C, Henson C, Reich M, Xie X, Mootha VK. Disease gene discovery through integrative genomics. Annu Rev Genomics Hum Genet. 2005; 6:381-406. PMID: 16124867.
    Citations: 34     Fields:    Translation:Humans
  161. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 01; 119(1):121-35. PMID: 15454086.
    Citations: 560     Fields:    Translation:AnimalsCells
  162. Mancuso M, Filosto M, Mootha VK, Rocchi A, Pistolesi S, Murri L, DiMauro S, Siciliano G. A novel mitochondrial tRNAPhe mutation causes MERRF syndrome. Neurology. 2004 Jun 08; 62(11):2119-21. PMID: 15184630.
    Citations: 15     Fields:    Translation:HumansCells
  163. Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6570-5. PMID: 15100410.
    Citations: 284     Fields:    Translation:AnimalsCells
  164. Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES, Mann M. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell. 2003 Nov 26; 115(5):629-40. PMID: 14651853.
    Citations: 330     Fields:    Translation:HumansAnimalsCells
  165. Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, Ridderstråle M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, Tamayo P, Spiegelman B, Lander ES, Hirschhorn JN, Altshuler D, Groop LC. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003 Jul; 34(3):267-73. PMID: 12808457.
    Citations: 3574     Fields:    Translation:HumansAnimalsCells
  166. Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, Rioux JD, Lander ES. Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):605-10. PMID: 12529507.
    Citations: 235     Fields:    Translation:HumansCells
  167. Ray HN, Mootha VK, Boxwala AA. Building an application framework for integrative genomics. AMIA Annu Symp Proc. 2003; 981. PMID: 14728485.
    Citations:    Fields:    
  168. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82. PMID: 11741533.
    Citations: 287     Fields:    Translation:HumansAnimalsCells
  169. Mootha VK, Wei MC, Buttle KF, Scorrano L, Panoutsakopoulou V, Mannella CA, Korsmeyer SJ. A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c. EMBO J. 2001 Feb 15; 20(4):661-71. PMID: 11179211.
    Citations: 46     Fields:    Translation:AnimalsCells
  170. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 2000 Aug 15; 14(16):2060-71. PMID: 10950869.
    Citations: 371     Fields:    Translation:AnimalsCells
  171. Mootha VK, Feldman J, Mannting F, Winters GL, Johnson W. Pheochromocytoma-induced cardiomyopathy. Circulation. 2000 Jul 04; 102(1):E11-3. PMID: 10880429.
    Citations: 2     Fields:    Translation:Humans
  172. Vidal-Puig AJ, Grujic D, Zhang CY, Hagen T, Boss O, Ido Y, Szczepanik A, Wade J, Mootha V, Cortright R, Muoio DM, Lowell BB. Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem. 2000 May 26; 275(21):16258-66. PMID: 10748196.
    Citations: 158     Fields:    Translation:AnimalsCells
  173. Territo PR, Mootha VK, French SA, Balaban RS. Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Physiol Cell Physiol. 2000 Feb; 278(2):C423-35. PMID: 10666039.