Harvard Catalyst Profiles

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Junichi Hanai, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nakajima A, F Shuler C, Gulka AOD, Hanai JI. TGF-ß Signaling and the Epithelial-Mesenchymal Transition during Palatal Fusion. Int J Mol Sci. 2018 Nov 19; 19(11). PMID: 30463190.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  2. Ide N, Ye R, Courbebaisse M, Olauson H, Densmore MJ, Larsson TE, Hanai JI, Lanske B. In vivo evidence for an interplay of FGF23/Klotho/PTH axis on the phosphate handling in renal proximal tubules. Am J Physiol Renal Physiol. 2018 11 01; 315(5):F1261-F1270. PMID: 29993278.
    Citations: 10     Fields:    Translation:AnimalsCells
  3. Ren JG, Seth P, Ye H, Guo K, Hanai JI, Husain Z, Sukhatme VP. Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway. Sci Rep. 2017 07 03; 7(1):4537. PMID: 28674429.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  4. Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 09; 92(3):599-611. PMID: 28396120.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  5. Sato T, Courbebaisse M, Ide N, Fan Y, Hanai JI, Kaludjerovic J, Densmore MJ, Yuan Q, Toka HR, Pollak MR, Hou J, Lanske B. Parathyroid hormone controls paracellular Ca2+ transport in the thick ascending limb by regulating the tight-junction protein Claudin14. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):E3344-E3353. PMID: 28373577.
    Citations: 17     Fields:    Translation:AnimalsCells
  6. Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017 03 07; 25(3):661-672. PMID: 28162969.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  7. Jernigan FE, Hanai JI, Sukhatme VP, Sun L. Discovery of furan carboxylate derivatives as novel inhibitors of ATP-citrate lyase via virtual high-throughput screening. Bioorg Med Chem Lett. 2017 02 15; 27(4):929-935. PMID: 28129980.
    Citations: 2     Fields:    Translation:HumansCells
  8. Koerner SK, Hanai JI, Bai S, Jernigan FE, Oki M, Komaba C, Shuto E, Sukhatme VP, Sun L. Design and synthesis of emodin derivatives as novel inhibitors of ATP-citrate lyase. Eur J Med Chem. 2017 Jan 27; 126:920-928. PMID: 27997879.
    Citations: 14     Fields:    Translation:HumansCells
  9. Tanaka T, Ikegami Y, Nakazawa H, Kuriyama N, Oki M, Hanai J, Sukhatme VP, Kaneki M. Low-Dose Farnesyltransferase Inhibitor Suppresses HIF-1a and Snail Expression in Triple-Negative Breast Cancer MDA-MB-231 Cells In Vitro. J Cell Physiol. 2017 01; 232(1):192-201. PMID: 27137755.
    Citations: 15     Fields:    Translation:HumansCells
  10. Ide N, Olauson H, Sato T, Densmore MJ, Wang H, Hanai JI, Larsson TE, Lanske B. In vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling. Kidney Int. 2016 08; 90(2):348-362. PMID: 27292223.
    Citations: 23     Fields:    Translation:HumansAnimals
  11. Imai R, Asai K, Hanai J, Takenaka M. Transgenic mice overexpressing glia maturation factor-ß, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation. Aging (Albany NY). 2015 Jul; 7(7):486-99. PMID: 26232943.
    Citations: 6     Fields:    Translation:AnimalsCells
  12. Kishi S, Bayliss PE, Hanai J. A prospective epigenetic paradigm between cellular senescence and epithelial-mesenchymal transition in organismal development and aging. Transl Res. 2015 Jan; 165(1):241-9. PMID: 24924348.
    Citations: 8     Fields:    Translation:HumansAnimals
  13. Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell Metab. 2014 May 06; 19(5):795-809. PMID: 24726384.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  14. Hanai JI, Doro N, Seth P, Sukhatme VP. ATP citrate lyase knockdown impacts cancer stem cells in vitro. Cell Death Dis. 2013 Jun 27; 4:e696. PMID: 23807225.
    Citations: 41     Fields:    Translation:HumansCells
  15. Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. J Cell Physiol. 2012 Apr; 227(4):1709-20. PMID: 21688263.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  16. Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK. A small-molecule screening strategy to identify suppressors of statin myopathy. ACS Chem Biol. 2011 Sep 16; 6(9):900-4. PMID: 21732624.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Koshimizu E, Imamura S, Qi J, Toure J, Valdez DM, Carr CE, Hanai J, Kishi S. Embryonic senescence and laminopathies in a progeroid zebrafish model. PLoS One. 2011 Mar 30; 6(3):e17688. PMID: 21479207.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  18. Cao P, Hanai J, Tanksale P, Imamura S, Sukhatme VP, Lecker SH. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J. 2009 Sep; 23(9):2844-54. PMID: 19406843.
    Citations: 38     Fields:    Translation:AnimalsCells
  19. Nakano A, Koinuma D, Miyazawa K, Uchida T, Saitoh M, Kawabata M, Hanai J, Akiyama H, Abe M, Miyazono K, Matsumoto T, Imamura T. Pin1 down-regulates transforming growth factor-beta (TGF-beta) signaling by inducing degradation of Smad proteins. J Biol Chem. 2009 Mar 06; 284(10):6109-15. PMID: 19122240.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  20. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 2008; 3(10):e3364. PMID: 18846223.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  21. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, Kishi S, Yamashita M, Phillips PS, Sukhatme VP, Lecker SH. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007 Dec; 117(12):3940-51. PMID: 17992259.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  22. Hanai J. [BMP in the kidney: signaling, function and pathophysiological significance]. Clin Calcium. 2007 May; 17(5):704-10. PMID: 17470999.
    Citations:    Fields:    Translation:AnimalsCells
  23. Venkatesha S, Hanai J, Seth P, Karumanchi SA, Sukhatme VP. Lipocalin 2 antagonizes the proangiogenic action of ras in transformed cells. Mol Cancer Res. 2006 Nov; 4(11):821-9. PMID: 17114340.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  24. Mochida Y, Parisuthiman D, Kaku M, Hanai J, Sukhatme VP, Yamauchi M. Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. J Biol Chem. 2006 Nov 24; 281(47):36044-51. PMID: 16990280.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Hu G, Tang J, Zhang B, Lin Y, Hanai J, Galloway J, Bedell V, Bahary N, Han Z, Ramchandran R, Thisse B, Thisse C, Zon LI, Sukhatme VP. A novel endothelial-specific heat shock protein HspA12B is required in both zebrafish development and endothelial functions in vitro. J Cell Sci. 2006 Oct 01; 119(Pt 19):4117-26. PMID: 16968741.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  26. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D'Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006 Jun; 12(6):642-9. PMID: 16751767.
    Citations: 580     Fields:    Translation:HumansAnimalsCells
  27. Tang J, Hu G, Hanai J, Yadlapalli G, Lin Y, Zhang B, Galloway J, Bahary N, Sinha S, Thisse B, Thisse C, Jin JP, Zon LI, Sukhatme VP. A critical role for calponin 2 in vascular development. J Biol Chem. 2006 Mar 10; 281(10):6664-72. PMID: 16317011.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  28. Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP. Magic roundabout, a tumor endothelial marker: expression and signaling. Biochem Biophys Res Commun. 2005 Jul 01; 332(2):533-41. PMID: 15894287.
    Citations: 51     Fields:    Translation:HumansCells
  29. Hanai J, Mammoto T, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem. 2005 Apr 08; 280(14):13641-7. PMID: 15691834.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  30. Kale S, Hanai J, Chan B, Karihaloo A, Grotendorst G, Cantley L, Sukhatme VP. Microarray analysis of in vitro pericyte differentiation reveals an angiogenic program of gene expression. FASEB J. 2005 Feb; 19(2):270-1. PMID: 15579670.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  31. Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem. 2004 Apr 16; 279(16):16388-93. PMID: 14754879.
    Citations: 18     Fields:    Translation:AnimalsCells
  32. Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003 Jul; 9(7):964-8. PMID: 12808448.
    Citations: 518     Fields:    Translation:AnimalsCells
  33. Hanai J, Gloy J, Karumanchi SA, Kale S, Tang J, Hu G, Chan B, Ramchandran R, Jha V, Sukhatme VP, Sokol S. Endostatin is a potential inhibitor of Wnt signaling. J Cell Biol. 2002 Aug 05; 158(3):529-39. PMID: 12147676.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  34. Hanai J, Dhanabal M, Karumanchi SA, Albanese C, Waterman M, Chan B, Ramchandran R, Pestell R, Sukhatme VP. Endostatin causes G1 arrest of endothelial cells through inhibition of cyclin D1. J Biol Chem. 2002 May 10; 277(19):16464-9. PMID: 11815623.
    Citations: 63     Fields:    Translation:HumansCells
  35. Ramchandran R, Karumanchi SA, Hanai J, Alper SL, Sukhatme VP. Cellular actions and signaling by endostatin. Crit Rev Eukaryot Gene Expr. 2002; 12(3):175-91. PMID: 12449342.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP. Cell surface glypicans are low-affinity endostatin receptors. Mol Cell. 2001 Apr; 7(4):811-22. PMID: 11336704.
    Citations: 67     Fields:    Translation:AnimalsCells
  37. Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, Hanai JI, Beppu H, Tsukazaki T, Wrana JL, Miyazono K, Sugamura K. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol. 2000 Dec; 20(24):9346-55. PMID: 11094085.
    Citations: 51     Fields:    Translation:AnimalsCells
  38. Zhang YW, Yasui N, Ito K, Huang G, Fujii M, Hanai J, Nogami H, Ochi T, Miyazono K, Ito Y. A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10549-54. PMID: 10962029.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  39. Udagawa Y, Hanai J, Tada K, Grieder NC, Momoeda M, Taketani Y, Affolter M, Kawabata M, Miyazono K. Schnurri interacts with Mad in a Dpp-dependent manner. Genes Cells. 2000 May; 5(5):359-69. PMID: 10886364.
    Citations: 6     Fields:    Translation:AnimalsCells
  40. Hanai J, Miyazono K. [PEBP2/CBF is a nuclear target of Smads in TGF-beta super family signaling]. Tanpakushitsu Kakusan Koso. 2000 Jan; 45(1):48-54. PMID: 10643335.
    Citations:    Fields:    Translation:HumansAnimalsCells
  41. Akiyoshi S, Inoue H, Hanai J, Kusanagi K, Nemoto N, Miyazono K, Kawabata M. c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads. J Biol Chem. 1999 Dec 03; 274(49):35269-77. PMID: 10575014.
    Citations: 103     Fields:    Translation:AnimalsCells
  42. Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, Imamura T, Ishidou Y, Fukuchi M, Shi MJ, Stavnezer J, Kawabata M, Miyazono K, Ito Y. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem. 1999 Oct 29; 274(44):31577-82. PMID: 10531362.
    Citations: 98     Fields:    Translation:Cells
  43. Nishihara A, Hanai J, Imamura T, Miyazono K, Kawabata M. E1A inhibits transforming growth factor-beta signaling through binding to Smad proteins. J Biol Chem. 1999 Oct 01; 274(40):28716-23. PMID: 10497242.
    Citations: 20     Fields:    Translation:AnimalsCells
  44. Takaichi K, Miyajima Y, Hanai JI, Kurokawa K, Fujita T, Warnock DG. Expression of transfected human Na+/H+ exchanger (NHE-1) in the the basolateral membrane of opossum kidney cells. J Cell Physiol. 1999 Jan; 178(1):44-50. PMID: 9886489.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Kawabata M, Imamura T, Inoue H, Hanai J, Nishihara A, Hanyu A, Takase M, Ishidou Y, Udagawa Y, Oeda E, Goto D, Yagi K, Kato M, Miyazono K. Intracellular signaling of the TGF-beta superfamily by Smad proteins. Ann N Y Acad Sci. 1999; 886:73-82. PMID: 10667205.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Nishihara A, Hanai JI, Okamoto N, Yanagisawa J, Kato S, Miyazono K, Kawabata M. Role of p300, a transcriptional coactivator, in signalling of TGF-beta. Genes Cells. 1998 Sep; 3(9):613-23. PMID: 9813111.
    Citations: 30     Fields:    Translation:AnimalsCells
  47. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, Miyazono K. Smad6 inhibits signalling by the TGF-beta superfamily. Nature. 1997 Oct 09; 389(6651):622-6. PMID: 9335505.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  48. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, ten Dijke P. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 1997 Sep 01; 16(17):5353-62. PMID: 9311995.
    Citations: 274     Fields:    Translation:HumansAnimalsCells
  49. Hanai JI, Takaichi K, Miyajima Y, Fujita T, Kurokawa K. Na+/H+ exchanger (NHE) in the basolateral membrane is encoded by NHE-1 mRNA in LLC-PK1 clone 4 cells. J Cell Physiol. 1997 Jun; 171(3):318-24. PMID: 9180901.
    Citations:    Fields:    Translation:AnimalsCells
  50. Tanemoto M, Miyakawa H, Hanai J, Yago M, Kitaoka M, Uchida S. Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis complicating the course of Graves' disease: report of three adult cases. Am J Kidney Dis. 1995 Nov; 26(5):774-80. PMID: 7485130.
    Citations: 9     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.