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profileCharles Andrew Czeisler, M.D., PH.D.

TitleFrank Baldino, Jr., Ph.D. Professor of Sleep Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Div of Sleep Medicine Rm 438A
221 Longwood Ave
Boston MA 02115
Phone617/732-4013
Fax617/732-4015
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM105018     (CZEISLER, CHARLES A)Jul 18, 2013 - Mar 31, 2018
NIH/NIGMS
Multi-scale modeling of sleep behaviors in social networks
Role: Principal Investigator

U01HL111478     (CZEISLER, CHARLES A)Sep 15, 2012 - Jan 31, 2018
NIH/NHLBI
Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCC
Role: Principal Investigator

R01HL094654     (CZEISLER, CHARLES A)Jul 1, 2010 - Jun 30, 2014
NIH/NHLBI
Sensitization of Human Circadian Responses to Light
Role: Principal Investigator

P30HL101299     (CZEISLER, CHARLES A)Sep 30, 2009 - Aug 31, 2012
NIH/NHLBI
New Faculty in Sleep Medicine
Role: Principal Investigator

R01HL093279     (CZEISLER, CHARLES A)May 1, 2009 - Apr 30, 2014
NIH/NHLBI
Efficacy of melatonin treatment in a phase advance model of insomnia
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rahman SA, St Hilaire MA, Chang AM, Santhi N, Duffy JF, Kronauer RE, Czeisler CA, Lockley SW, Klerman EB. Circadian phase resetting by a single short-duration light exposure. JCI Insight. 2017 Apr 06; 2(7):e89494. PMID: 28405608.
    View in: PubMed
  2. Cain SW, Chang AM, Vlasac I, Tare A, Anderson C, Czeisler CA, Saxena R. Circadian Rhythms in Plasma Brain-derived Neurotrophic Factor Differ in Men and Women. J Biol Rhythms. 2017 Feb; 32(1):75-82. PMID: 28326910.
    View in: PubMed
  3. Higgins JS, Michael J, Austin R, Åkerstedt T, Van Dongen HP, Watson N, Czeisler C, Pack AI, Rosekind MR. Asleep at the Wheel-The Road to Addressing Drowsy Driving. Sleep. 2017 Feb 01; 40(2). PMID: 28364516.
    View in: PubMed
  4. Sullivan JP, O'Brien CS, Barger LK, Rajaratnam SM, Czeisler CA, Lockley SW. Randomized, Prospective Study of the Impact of a Sleep Health Program on Firefighter Injury and Disability. Sleep. 2017 Jan 01; 40(1). PMID: 28364446.
    View in: PubMed
  5. Czeisler CA, Shanahan TL. Problems Associated With Use of Mobile Devices in the Sleep Environment-Streaming Instead of Dreaming. JAMA Pediatr. 2016 Dec 01; 170(12):1146-1147. PMID: 27802458.
    View in: PubMed
  6. Walsh L, McLoone S, Ronda J, Duffy JF, Czeisler CA. Non-contact Pressure-based Sleep/Wake Discrimination. IEEE Trans Biomed Eng. 2016 Oct 25. PMID: 27845651.
    View in: PubMed
  7. Walsh L, McLoone S, Ronda J, Duffy JF, Czeisler CA. Non-contact Pressure-based Sleep/Wake Discrimination. IEEE Trans Biomed Eng. 2016 Oct 25. PMID: 28113254.
    View in: PubMed
  8. Sullivan JP, O'Brien CS, Barger LK, Rajaratnam SM, Czeisler CA, Lockley SW. Randomized, prospective study of the impact of a sleep health program on firefighter injury and disability. Sleep. 2016 Sep 26. PMID: 27692049.
    View in: PubMed
  9. Czeisler CA. SLEEP. Measuring the passage of brain time. Science. 2016 Aug 12; 353(6300):648-9. PMID: 27516585.
    View in: PubMed
  10. Sigurdardottir LG, Markt SC, Sigurdsson S, Aspelund T, Fall K, Schernhammer E, Rider JR, Launer L, Harris T, Stampfer MJ, Gudnason V, Czeisler CA, Lockley SW, Valdimarsdottir UA, Mucci LA. Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men. J Biol Rhythms. 2016 Oct; 31(5):461-9. PMID: 27449477.
    View in: PubMed
  11. Kales SN, Czeisler CA. Obstructive Sleep Apnea and Work Accidents: Time for Action. Sleep. 2016 06 01; 39(6):1171-3. PMID: 27166231; PMCID: PMC4863202 [Available on 12/01/16].
  12. Barger LK, O'Brien CS, Rajaratnam SM, Qadri S, Sullivan JP, Wang W, Czeisler CA, Lockley SW. Implementing a Sleep Health Education and Sleep Disorders Screening Program in Fire Departments: A Comparison of Methodology. J Occup Environ Med. 2016 Jun; 58(6):601-9. PMID: 27035103; PMCID: PMC4883642.
  13. Burks SV, Anderson JE, Bombyk M, Haider R, Ganzhorn D, Jiao X, Lewis C, Lexvold A, Liu H, Ning J, Toll A, Hickman JS, Mabry E, Berger M, Malhotra A, Czeisler CA, Kales SN. Nonadherence with Employer-Mandated Sleep Apnea Treatment and Increased Risk of Serious Truck Crashes. Sleep. 2016 05 01; 39(5):967-75. PMID: 27070139; PMCID: PMC4835318 [Available on 11/01/16].
  14. Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73. PMID: 27089043.
    View in: PubMed
  15. de la Iglesia HO, Moreno C, Lowden A, Louzada F, Marqueze E, Levandovski R, Pilz LK, Valeggia C, Fernandez-Duque E, Golombek DA, Czeisler CA, Skene DJ, Duffy JF, Roenneberg T. Ancestral sleep. Curr Biol. 2016 Apr 04; 26(7):R271-2. PMID: 27046809.
    View in: PubMed
  16. Bermudez EB, Klerman EB, Czeisler CA, Cohen DA, Wyatt JK, Phillips AJ. Prediction of Vigilant Attention and Cognitive Performance Using Self-Reported Alertness, Circadian Phase, Hours since Awakening, and Accumulated Sleep Loss. PLoS One. 2016; 11(3):e0151770. PMID: 27019198; PMCID: PMC4809494.
  17. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 Jun; 65(6):1741-51. PMID: 26868293; PMCID: PMC4878414 [Available on 06/01/17].
  18. Lee ML, Howard ME, Horrey WJ, Liang Y, Anderson C, Shreeve MS, O'Brien CS, Czeisler CA. High risk of near-crash driving events following night-shift work. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):176-81. PMID: 26699470; PMCID: PMC4711869.
  19. Markt SC, Flynn-Evans EE, Valdimarsdottir UA, Sigurdardottir LG, Tamimi RM, Batista JL, Haneuse S, Lockley SW, Stampfer M, Wilson KM, Czeisler CA, Rider JR, Mucci LA. Sleep Duration and Disruption and Prostate Cancer Risk: a 23-Year Prospective Study. Cancer Epidemiol Biomarkers Prev. 2016 Feb; 25(2):302-8. PMID: 26677208; PMCID: PMC4767658 [Available on 02/01/17].
  20. Arble DM, Bass J, Behn CD, Butler MP, Challet E, Czeisler C, Depner CM, Elmquist J, Franken P, Grandner MA, Hanlon EC, Keene AC, Joyner MJ, Karatsoreos I, Kern PA, Klein S, Morris CJ, Pack AI, Panda S, Ptacek LJ, Punjabi NM, Sassone-Corsi P, Scheer FA, Saxena R, Seaquest ER, Thimgan MS, Van Cauter E, Wright KP. Impact of Sleep and Circadian Disruption on Energy Balance and Diabetes: A Summary of Workshop Discussions. Sleep. 2015 Dec 01; 38(12):1849-60. PMID: 26564131; PMCID: PMC4667373.
  21. Maurer L, Zitting KM, Elliott K, Czeisler CA, Ronda JM, Duffy JF. A new face of sleep: The impact of post-learning sleep on recognition memory for face-name associations. Neurobiol Learn Mem. 2015 Dec; 126:31-8. PMID: 26549626; PMCID: PMC4666502 [Available on 12/01/16].
  22. Rajaratnam SM, Landrigan CP, Czeisler CA. Graduated Driver-Licensing: The Authors Reply. Health Aff (Millwood). 2015 Sep; 34(9):1610. PMID: 26355070.
    View in: PubMed
  23. de la Iglesia HO, Fernández-Duque E, Golombek DA, Lanza N, Duffy JF, Czeisler CA, Valeggia CR. Access to Electric Light Is Associated with Shorter Sleep Duration in a Traditionally Hunter-Gatherer Community. J Biol Rhythms. 2015 Aug; 30(4):342-50. PMID: 26092820.
    View in: PubMed
  24. Rajaratnam SM, Landrigan CP, Wang W, Kaprielian R, Moore RT, Czeisler CA. Teen Crashes Declined After Massachusetts Raised Penalties For Graduated Licensing Law Restricting Night Driving. Health Aff (Millwood). 2015 Jun; 34(6):963-70. PMID: 26056201.
    View in: PubMed
  25. Duffy JF, Zitting KM, Czeisler CA. The Case for Addressing Operator Fatigue. Rev Hum Factors Ergon. 2015 Jun; 10(1):29-78. PMID: 26056516.
    View in: PubMed
  26. Barger LK, Rajaratnam SM, Wang W, O'Brien CS, Sullivan JP, Qadri S, Lockley SW, Czeisler CA. Common sleep disorders increase risk of motor vehicle crashes and adverse health outcomes in firefighters. J Clin Sleep Med. 2015 Mar 15; 11(3):233-40. PMID: 25580602; PMCID: PMC4346644.
  27. Burke TM, Scheer FA, Ronda JM, Czeisler CA, Wright KP. Sleep inertia, sleep homeostatic and circadian influences on higher-order cognitive functions. J Sleep Res. 2015 Aug; 24(4):364-71. PMID: 25773686.
    View in: PubMed
  28. Chang AM, Czeisler CA. Reply to Zeitzer: Good science, in or out of the laboratory, should prevail. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):E1514. PMID: 25762077; PMCID: PMC4386345.
  29. Wright KP, Drake AL, Frey DJ, Fleshner M, Desouza CA, Gronfier C, Czeisler CA. Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance. Brain Behav Immun. 2015 Jul; 47:24-34. PMID: 25640603.
    View in: PubMed
  30. Aronow HD, Gurm HS, Blankenship JC, Czeisler CA, Wang TY, McCoy LA, Neely ML, Spertus JA. Middle-of-the-night percutaneous coronary intervention and its association with percutaneous coronary intervention outcomes performed the following day: an analysis from the National Cardiovascular Data Registry. JACC Cardiovasc Interv. 2015 Jan; 8(1 Pt A):49-56. PMID: 25616817.
    View in: PubMed
  31. Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1232-7. PMID: 25535358; PMCID: PMC4313820.
  32. Rahman SA, Castanon-Cervantes O, Scheer FA, Shea SA, Czeisler CA, Davidson AJ, Lockley SW. Endogenous circadian regulation of pro-inflammatory cytokines and chemokines in the presence of bacterial lipopolysaccharide in humans. Brain Behav Immun. 2015 Jul; 47:4-13. PMID: 25452149; PMCID: PMC4430446.
  33. Markt SC, Valdimarsdottir UA, Shui IM, Sigurdardottir LG, Rider JR, Tamimi RM, Batista JL, Haneuse S, Flynn-Evans E, Lockley SW, Czeisler CA, Stampfer MJ, Launer L, Harris T, Smith AV, Gudnason V, Lindstrom S, Kraft P, Mucci LA. Circadian clock genes and risk of fatal prostate cancer. Cancer Causes Control. 2015 Jan; 26(1):25-33. PMID: 25388799; PMCID: PMC4282953.
  34. Barger LK, Flynn-Evans EE, Kubey A, Walsh L, Ronda JM, Wang W, Wright KP, Czeisler CA. Prevalence of sleep deficiency and use of hypnotic drugs in astronauts before, during, and after spaceflight: an observational study. Lancet Neurol. 2014 Sep; 13(9):904-12. PMID: 25127232; PMCID: PMC4188436.
  35. Sigurdardottir LG, Markt SC, Rider JR, Haneuse S, Fall K, Schernhammer ES, Tamimi RM, Flynn-Evans E, Batista JL, Launer L, Harris T, Aspelund T, Stampfer MJ, Gudnason V, Czeisler CA, Lockley SW, Valdimarsdottir UA, Mucci LA. Urinary melatonin levels, sleep disruption, and risk of prostate cancer in elderly men. Eur Urol. 2015 Feb; 67(2):191-4. PMID: 25107635; PMCID: PMC4318783 [Available on 02/01/16].
  36. Devore EE, Grodstein F, Duffy JF, Stampfer MJ, Czeisler CA, Schernhammer ES. Sleep duration in midlife and later life in relation to cognition. J Am Geriatr Soc. 2014 Jun; 62(6):1073-81. PMID: 24786726; PMCID: PMC4188530.
  37. Rahman SA, Flynn-Evans EE, Aeschbach D, Brainard GC, Czeisler CA, Lockley SW. Diurnal spectral sensitivity of the acute alerting effects of light. Sleep. 2014 Feb 01; 37(2):271-81. PMID: 24501435; PMCID: PMC3900613.
  38. Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF. Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2. J Clin Endocrinol Metab. 2014 Mar; 99(3):E561-6. PMID: 24423319; PMCID: PMC3942237.
  39. Gradisar M, Wolfson AR, Harvey AG, Hale L, Rosenberg R, Czeisler CA. The sleep and technology use of Americans: findings from the National Sleep Foundation's 2011 Sleep in America poll. J Clin Sleep Med. 2013 Dec 15; 9(12):1291-9. PMID: 24340291; PMCID: PMC3836340.
  40. Lucas RJ, Peirson SN, Berson DM, Brown TM, Cooper HM, Czeisler CA, Figueiro MG, Gamlin PD, Lockley SW, O'Hagan JB, Price LL, Provencio I, Skene DJ, Brainard GC. Measuring and using light in the melanopsin age. Trends Neurosci. 2014 Jan; 37(1):1-9. PMID: 24287308; PMCID: PMC4699304.
  41. Anderson C, Chang AM, Sullivan JP, Ronda JM, Czeisler CA. Assessment of drowsiness based on ocular parameters detected by infrared reflectance oculography. J Clin Sleep Med. 2013 Sep 15; 9(9):907-20, 920A-920B. PMID: 23997703; PMCID: PMC3746718.
  42. Chang AM, Scheer FA, Czeisler CA, Aeschbach D. Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46. PMID: 23904684; PMCID: PMC3700721.
  43. Vandewalle G, Collignon O, Hull JT, Daneault V, Albouy G, Lepore F, Phillips C, Doyon J, Czeisler CA, Dumont M, Lockley SW, Carrier J. Blue light stimulates cognitive brain activity in visually blind individuals. J Cogn Neurosci. 2013 Dec; 25(12):2072-85. PMID: 23859643; PMCID: PMC4497579.
  44. Czeisler CA. Perspective: casting light on sleep deficiency. Nature. 2013 May 23; 497(7450):S13. PMID: 23698501.
    View in: PubMed
  45. Sigurdardottir LG, Valdimarsdottir UA, Mucci LA, Fall K, Rider JR, Schernhammer E, Czeisler CA, Launer L, Harris T, Stampfer MJ, Gudnason V, Lockley SW. Sleep disruption among older men and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2013 May; 22(5):872-9. PMID: 23652374; PMCID: PMC3652595.
  46. Shekleton JA, Rajaratnam SM, Gooley JJ, Van Reen E, Czeisler CA, Lockley SW. Improved neurobehavioral performance during the wake maintenance zone. J Clin Sleep Med. 2013 Apr 15; 9(4):353-62. PMID: 23585751; PMCID: PMC3601314.
  47. Czeisler CA, Pellegrini CA, Sade RM. Should sleep-deprived surgeons be prohibited from operating without patients' consent? Ann Thorac Surg. 2013 Feb; 95(2):757-66. PMID: 23336899; PMCID: PMC4497533.
  48. Crowley KE, Rajaratnam SM, Shea SA, Epstein LJ, Czeisler CA, Lockley SW. Evaluation of a single-channel nasal pressure device to assess obstructive sleep apnea risk in laboratory and home environments. J Clin Sleep Med. 2013 Feb 01; 9(2):109-16. PMID: 23372462; PMCID: PMC3544377.
  49. Cohen IG, Czeisler CA, Landrigan CP. Making residency work hour rules work. J Law Med Ethics. 2013; 41(1):310-4. PMID: 23581673.
    View in: PubMed
  50. Rüger M, St Hilaire MA, Brainard GC, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a single 6.5 h pulse of short-wavelength light. J Physiol. 2013 Jan 01; 591(1):353-63. PMID: 23090946; PMCID: PMC3630790.
  51. Gooley JJ, Ho Mien I, St Hilaire MA, Yeo SC, Chua EC, van Reen E, Hanley CJ, Hull JT, Czeisler CA, Lockley SW. Melanopsin and rod-cone photoreceptors play different roles in mediating pupillary light responses during exposure to continuous light in humans. J Neurosci. 2012 Oct 10; 32(41):14242-53. PMID: 23055493; PMCID: PMC3515688.
  52. Lim AS, Chang AM, Shulman JM, Raj T, Chibnik LB, Cain SW, Rothamel K, Benoist C, Myers AJ, Czeisler CA, Buchman AS, Bennett DA, Duffy JF, Saper CB, De Jager PL. A common polymorphism near PER1 and the timing of human behavioral rhythms. Ann Neurol. 2012 Sep; 72(3):324-34. PMID: 23034908; PMCID: PMC3464954.
  53. Berger M, Varvarigou V, Rielly A, Czeisler CA, Malhotra A, Kales SN. Employer-mandated sleep apnea screening and diagnosis in commercial drivers. J Occup Environ Med. 2012 Aug; 54(8):1017-25. PMID: 22850349; PMCID: PMC3415601.
  54. Anderson C, Sullivan JP, Flynn-Evans EE, Cade BE, Czeisler CA, Lockley SW. Deterioration of neurobehavioral performance in resident physicians during repeated exposure to extended duration work shifts. Sleep. 2012 Aug 01; 35(8):1137-46. PMID: 22851809; PMCID: PMC3397817.
  55. Pomplun M, Silva EJ, Ronda JM, Cain SW, Münch MY, Czeisler CA, Duffy JF. The effects of circadian phase, time awake, and imposed sleep restriction on performing complex visual tasks: evidence from comparative visual search. J Vis. 2012 Jul 26; 12(7). PMID: 22836655; PMCID: PMC4503214.
  56. Klerman EB, Wang W, Duffy JF, Dijk DJ, Czeisler CA, Kronauer RE. Survival analysis indicates that age-related decline in sleep continuity occurs exclusively during NREM sleep. Neurobiol Aging. 2013 Jan; 34(1):309-18. PMID: 22727943; PMCID: PMC3469724.
  57. St Hilaire MA, Gooley JJ, Khalsa SB, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light. J Physiol. 2012 Jul 01; 590(13):3035-45. PMID: 22547633; PMCID: PMC3406389.
  58. Chang AM, Santhi N, St Hilaire M, Gronfier C, Bradstreet DS, Duffy JF, Lockley SW, Kronauer RE, Czeisler CA. Human responses to bright light of different durations. J Physiol. 2012 Jul 01; 590(13):3103-12. PMID: 22526883; PMCID: PMC3406393.
  59. Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med. 2012 Apr 11; 4(129):129ra43. PMID: 22496545; PMCID: PMC3678519.
  60. Dijk DJ, Duffy JF, Silva EJ, Shanahan TL, Boivin DB, Czeisler CA. Amplitude reduction and phase shifts of melatonin, cortisol and other circadian rhythms after a gradual advance of sleep and light exposure in humans. PLoS One. 2012; 7(2):e30037. PMID: 22363414; PMCID: PMC3281823.
  61. Sigurdardottir L, Valdimarsdottir UA, Mucci L, Fall K, Rider JR, Schernhammer ES, Czeisler CA, Launer L, Harris TB, Stampfer MJ, Gudnason V, Lockley SW. Insomnia among elderly men and risk of prostate cancer. J Clin Oncol. 2012 Feb 10; 30(5_suppl):78. PMID: 28142941.
    View in: PubMed
  62. Rajaratnam SM, Barger LK, Lockley SW, Shea SA, Wang W, Landrigan CP, O'Brien CS, Qadri S, Sullivan JP, Cade BE, Epstein LJ, White DP, Czeisler CA. Sleep disorders, health, and safety in police officers. JAMA. 2011 Dec 21; 306(23):2567-78. PMID: 22187276.
    View in: PubMed
  63. Mullington JM, Czeisler CA, Goel N, Krueger JM, Balkin TJ, Johns M, Shaw PJ. Panel discussion: current status of measuring sleepiness. J Clin Sleep Med. 2011 Oct 15; 7(5 Suppl):S22-5. PMID: 22003325; PMCID: PMC3190418.
  64. Czeisler CA. Impact of sleepiness and sleep deficiency on public health--utility of biomarkers. J Clin Sleep Med. 2011 Oct 15; 7(5 Suppl):S6-8. PMID: 22003334; PMCID: PMC3190420.
  65. Phillips AJ, Czeisler CA, Klerman EB. Revisiting spontaneous internal desynchrony using a quantitative model of sleep physiology. J Biol Rhythms. 2011 Oct; 26(5):441-53. PMID: 21921298; PMCID: PMC3557950.
  66. Blum AB, Shea S, Czeisler CA, Landrigan CP, Leape L. Implementing the 2009 Institute of Medicine recommendations on resident physician work hours, supervision, and safety. Nat Sci Sleep. 2011; 3:47-85. PMID: 23616719; PMCID: PMC3630963.
  67. Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP, Czeisler CA. Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci U S A. 2011 Sep 13; 108 Suppl 3:15602-8. PMID: 21536890; PMCID: PMC3176605.
  68. Balkin TJ, Horrey WJ, Graeber RC, Czeisler CA, Dinges DF. The challenges and opportunities of technological approaches to fatigue management. Accid Anal Prev. 2011 Mar; 43(2):565-72. PMID: 21130217.
    View in: PubMed
  69. Chang AM, Scheer FA, Czeisler CA. The human circadian system adapts to prior photic history. J Physiol. 2011 Mar 01; 589(Pt 5):1095-102. PMID: 21224217; PMCID: PMC3060589.
  70. Nurok M, Czeisler CA, Lehmann LS. Sleep deprivation, elective surgical procedures, and informed consent. N Engl J Med. 2010 Dec 30; 363(27):2577-9. PMID: 21190452.
    View in: PubMed
  71. Gooley JJ, Chamberlain K, Smith KA, Khalsa SB, Rajaratnam SM, Van Reen E, Zeitzer JM, Czeisler CA, Lockley SW. Exposure to room light before bedtime suppresses melatonin onset and shortens melatonin duration in humans. J Clin Endocrinol Metab. 2011 Mar; 96(3):E463-72. PMID: 21193540; PMCID: PMC3047226.
  72. Gordon JA, Alexander EK, Lockley SW, Flynn-Evans E, Venkatan SK, Landrigan CP, Czeisler CA. Does simulator-based clinical performance correlate with actual hospital behavior? The effect of extended work hours on patient care provided by medical interns. Acad Med. 2010 Oct; 85(10):1583-8. PMID: 20881679; PMCID: PMC3754850.
  73. Jung CM, Ronda JM, Czeisler CA, Wright KP. Comparison of sustained attention assessed by auditory and visual psychomotor vigilance tasks prior to and during sleep deprivation. J Sleep Res. 2011 Jun; 20(2):348-55. PMID: 20819145; PMCID: PMC3603691.
  74. Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N, Schoen MW, Czeisler CA, Duffy JF. Sex differences in phase angle of entrainment and melatonin amplitude in humans. J Biol Rhythms. 2010 Aug; 25(4):288-96. PMID: 20679498; PMCID: PMC3792014.
  75. Blum AB, Raiszadeh F, Shea S, Mermin D, Lurie P, Landrigan CP, Czeisler CA. US public opinion regarding proposed limits on resident physician work hours. BMC Med. 2010 Jun 01; 8:33. PMID: 20515479; PMCID: PMC2901227.
  76. Jung CM, Khalsa SB, Scheer FA, Cajochen C, Lockley SW, Czeisler CA, Wright KP. Acute effects of bright light exposure on cortisol levels. J Biol Rhythms. 2010 Jun; 25(3):208-16. PMID: 20484692; PMCID: PMC3686562.
  77. Grady S, Aeschbach D, Wright KP, Czeisler CA. Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment. Neuropsychopharmacology. 2010 Aug; 35(9):1910-20. PMID: 20505660; PMCID: PMC2904872.
  78. Gooley JJ, Rajaratnam SM, Brainard GC, Kronauer RE, Czeisler CA, Lockley SW. Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light. Sci Transl Med. 2010 May 12; 2(31):31ra33. PMID: 20463367; PMCID: PMC4414925.
  79. Czeisler CA. Wake-promoting therapeutic medications not an appropriate alternative to implementation of safer work schedules for resident physicians. Mayo Clin Proc. 2010 Mar; 85(3):302-3; author reply 303. PMID: 20194158; PMCID: PMC2843118.
  80. Münch M, Silva EJ, Ronda JM, Czeisler CA, Duffy JF. EEG sleep spectra in older adults across all circadian phases during NREM sleep. Sleep. 2010 Mar; 33(3):389-401. PMID: 20337198; PMCID: PMC2831434.
  81. Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB. Uncovering residual effects of chronic sleep loss on human performance. Sci Transl Med. 2010 Jan 13; 2(14):14ra3. PMID: 20371466; PMCID: PMC2892834.
  82. Czeisler CA, Walsh JK, Wesnes KA, Arora S, Roth T. Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study. Mayo Clin Proc. 2009 Nov; 84(11):958-72. PMID: 19880686; PMCID: PMC2770907.
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  184. Brown EN, Choe Y, Shanahan TL, Czeisler CA. A mathematical model of diurnal variations in human plasma melatonin levels. Am J Physiol. 1997 Mar; 272(3 Pt 1):E506-16. PMID: 9124558.
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  185. Boivin DB, Czeisler CA, Dijk DJ, Duffy JF, Folkard S, Minors DS, Totterdell P, Waterhouse JM. Complex interaction of the sleep-wake cycle and circadian phase modulates mood in healthy subjects. Arch Gen Psychiatry. 1997 Feb; 54(2):145-52. PMID: 9040282.
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  186. el-Hajj Fuleihan G, Klerman EB, Brown EN, Choe Y, Brown EM, Czeisler CA. The parathyroid hormone circadian rhythm is truly endogenous--a general clinical research center study. J Clin Endocrinol Metab. 1997 Jan; 82(1):281-6. PMID: 8989274.
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  187. Richardson GS, Wyatt JK, Sullivan JP, Orav EJ, Ward AE, Wolf MA, Czeisler CA. Objective assessment of sleep and alertness in medical house staff and the impact of protected time for sleep. Sleep. 1996 Nov; 19(9):718-26. PMID: 9122559.
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  188. Duffy JF, Kronauer RE, Czeisler CA. Phase-shifting human circadian rhythms: influence of sleep timing, social contact and light exposure. J Physiol. 1996 Aug 15; 495 ( Pt 1):289-97. PMID: 8866371; PMCID: PMC1160744.
  189. Waldstreicher J, Duffy JF, Brown EN, Rogacz S, Allan JS, Czeisler CA. Gender differences in the temporal organization of proclactin (PRL) secretion: evidence for a sleep-independent circadian rhythm of circulating PRL levels- a clinical research center study. J Clin Endocrinol Metab. 1996 Apr; 81(4):1483-7. PMID: 8636355.
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  190. Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Dose-response relationships for resetting of human circadian clock by light. Nature. 1996 Feb 08; 379(6565):540-2. PMID: 8596632.
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  191. Klerman EB, Dijk DJ, Kronauer RE, Czeisler CA. Simulations of light effects on the human circadian pacemaker: implications for assessment of intrinsic period. Am J Physiol. 1996 Jan; 270(1 Pt 2):R271-82. PMID: 8769811.
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  192. Czeisler CA, Dijk DJ. Use of bright light to treat maladaptation to night shift work and circadian rhythm sleep disorders. J Sleep Res. 1995 Dec; 4(S2):70-73. PMID: 10607216.
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  193. Dijk DJ, Czeisler CA. Contribution of the circadian pacemaker and the sleep homeostat to sleep propensity, sleep structure, electroencephalographic slow waves, and sleep spindle activity in humans. J Neurosci. 1995 May; 15(5 Pt 1):3526-38. PMID: 7751928.
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  194. Czeisler CA, Shanahan TL, Klerman EB, Martens H, Brotman DJ, Emens JS, Klein T, Rizzo JF. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med. 1995 Jan 05; 332(1):6-11. PMID: 7990870.
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  195. Czeisler CA. The effect of light on the human circadian pacemaker. Ciba Found Symp. 1995; 183:254-90; discussion 290-302. PMID: 7656689.
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  196. Budnick LD, Lerman SE, Baker TL, Jones H, Czeisler CA. Sleep and alertness in a 12-hour rotating shift work environment. J Occup Med. 1994 Dec; 36(12):1295-300. PMID: 7884570.
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  197. Allan JS, Czeisler CA. Persistence of the circadian thyrotropin rhythm under constant conditions and after light-induced shifts of circadian phase. J Clin Endocrinol Metab. 1994 Aug; 79(2):508-12. PMID: 8045970.
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  198. Dijk DJ, Czeisler CA. Paradoxical timing of the circadian rhythm of sleep propensity serves to consolidate sleep and wakefulness in humans. Neurosci Lett. 1994 Jan 17; 166(1):63-8. PMID: 8190360.
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  199. Boivin DB, Duffy JF, Kronauer RE, Czeisler CA. Sensitivity of the human circadian pacemaker to moderately bright light. J Biol Rhythms. 1994; 9(3-4):315-31. PMID: 7772798.
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  200. Jewett ME, Kronauer RE, Czeisler CA. Phase-amplitude resetting of the human circadian pacemaker via bright light: a further analysis. J Biol Rhythms. 1994; 9(3-4):295-314. PMID: 7772797.
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  201. Dijk DJ, Hayes B, Czeisler CA. Dynamics of electroencephalographic sleep spindles and slow wave activity in men: effect of sleep deprivation. Brain Res. 1993 Oct 29; 626(1-2):190-9. PMID: 8281430.
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  202. Dijk DJ, Czeisler CA. Body temperature is elevated during the rebound of slow-wave sleep following 40-h of sleep deprivation on a constant routine. J Sleep Res. 1993 Sep; 2(3):117-120. PMID: 10607081.
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  203. Klein T, Martens H, Dijk DJ, Kronauer RE, Seely EW, Czeisler CA. Circadian sleep regulation in the absence of light perception: chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule. Sleep. 1993 Jun; 16(4):333-43. PMID: 8341894.
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  204. Kronauer RE, Jewett ME, Czeisler CA. Commentary: the human circadian response to light--strong and weak resetting. J Biol Rhythms. 1993; 8(4):351-60; discussion 361. PMID: 8032094.
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  205. Czeisler CA, Dumont M, Duffy JF, Steinberg JD, Richardson GS, Brown EN, Sánchez R, Ríos CD, Ronda JM. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet. 1992 Oct 17; 340(8825):933-6. PMID: 1357348.
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  206. Hastings JW, Czeisler CA. Day-night differences are not always due to circadian control. Ann Emerg Med. 1992 Oct; 21(10):1236. PMID: 1416304.
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  207. Gold DR, Rogacz S, Bock N, Tosteson TD, Baum TM, Speizer FE, Czeisler CA. Rotating shift work, sleep, and accidents related to sleepiness in hospital nurses. Am J Public Health. 1992 Jul; 82(7):1011-4. PMID: 1609900; PMCID: PMC1694075.
  208. Dijk DJ, Duffy JF, Czeisler CA. Circadian and sleep/wake dependent aspects of subjective alertness and cognitive performance. J Sleep Res. 1992 Jun; 1(2):112-7. PMID: 10607036.
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  209. Johnson MP, Duffy JF, Dijk DJ, Ronda JM, Dyal CM, Czeisler CA. Short-term memory, alertness and performance: a reappraisal of their relationship to body temperature. J Sleep Res. 1992 Mar; 1(1):24-9. PMID: 10607021.
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  210. Brown EN, Czeisler CA. The statistical analysis of circadian phase and amplitude in constant-routine core-temperature data. J Biol Rhythms. 1992; 7(3):177-202. PMID: 1421473.
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  211. Czeisler CA, Richardson GS. Detection and assessment of insomnia. Clin Ther. 1991 Nov-Dec; 13(6):663-79; discussion 662. PMID: 1790541.
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  212. Shanahan TL, Czeisler CA. Light exposure induces equivalent phase shifts of the endogenous circadian rhythms of circulating plasma melatonin and core body temperature in men. J Clin Endocrinol Metab. 1991 Aug; 73(2):227-35. PMID: 1856258.
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  213. Kronauer RE, Jewett ME, Czeisler CA. Human circadian rhythms. Nature. 1991 May 16; 351(6323):193. PMID: 2041564.
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  214. Jewett ME, Kronauer RE, Czeisler CA. Light-induced suppression of endogenous circadian amplitude in humans. Nature. 1991 Mar 07; 350(6313):59-62. PMID: 2002845.
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  215. Wolf MA, Richardson G, Czeisler CA. Improved sleep: a means of reducing the stress of internship. Trans Am Clin Climatol Assoc. 1991; 102:225-9; discussion 229-31. PMID: 2130562; PMCID: PMC2376659.
  216. Czeisler CA, Chiasera AJ, Duffy JF. Research on sleep, circadian rhythms and aging: applications to manned spaceflight. Exp Gerontol. 1991; 26(2-3):217-32. PMID: 1915692.
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  217. Czeisler CA, Johnson MP, Duffy JF, Brown EN, Ronda JM, Kronauer RE. Exposure to bright light and darkness to treat physiologic maladaptation to night work. N Engl J Med. 1990 May 03; 322(18):1253-9. PMID: 2325721.
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  218. Czeisler CA, Kronauer RE, Allan JS, Duffy JF, Jewett ME, Brown EN, Ronda JM. Bright light induction of strong (type 0) resetting of the human circadian pacemaker. Science. 1989 Jun 16; 244(4910):1328-33. PMID: 2734611.
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  219. Richardson GS, Miner JD, Czeisler CA. Impaired driving performance in shiftworkers: the role of the circadian system in a multifactorial model. Alcohol Drugs Driving. 1989-1990; 5-6(4-1):265-73. PMID: 11538713.
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  220. Brezinski DA, Tofler GH, Muller JE, Pohjola-Sintonen S, Willich SN, Schafer AI, Czeisler CA, Williams GH. Morning increase in platelet aggregability. Association with assumption of the upright posture. Circulation. 1988 Jul; 78(1):35-40. PMID: 3289790.
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  221. Mitler MM, Carskadon MA, Czeisler CA, Dement WC, Dinges DF, Graeber RC. Catastrophes, sleep, and public policy: consensus report. Sleep. 1988 Feb; 11(1):100-9. PMID: 3283909; PMCID: PMC2517096.
  222. Czeisler CA, Kronauer RE, Mooney JJ, Anderson JL, Allan JS. Biologic rhythm disorders, depression, and phototherapy. A new hypothesis. Psychiatr Clin North Am. 1987 Dec; 10(4):687-709. PMID: 3332326.
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  223. Strogatz SH, Kronauer RE, Czeisler CA. Circadian pacemaker interferes with sleep onset at specific times each day: role in insomnia. Am J Physiol. 1987 Jul; 253(1 Pt 2):R172-8. PMID: 3605382.
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  224. Tofler GH, Brezinski D, Schafer AI, Czeisler CA, Rutherford JD, Willich SN, Gleason RE, Williams GH, Muller JE. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med. 1987 Jun 11; 316(24):1514-8. PMID: 3587281.
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  225. Czeisler CA, Allan JS. Response: moonlight and circadian rhythms. Science. 1987 Jan 09; 235(4785):145b. PMID: 17778615.
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  226. Gordon NP, Cleary PD, Parker CE, Czeisler CA. The prevalence and health impact of shiftwork. Am J Public Health. 1986 Oct; 76(10):1225-8. PMID: 3752325; PMCID: PMC1646676.
  227. Czeisler CA, Allan JS, Strogatz SH, Ronda JM, Sánchez R, Ríos CD, Freitag WO, Richardson GS, Kronauer RE. Bright light resets the human circadian pacemaker independent of the timing of the sleep-wake cycle. Science. 1986 Aug 08; 233(4764):667-71. PMID: 3726555.
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  228. Strogatz SH, Kronauer RE, Czeisler CA. Circadian regulation dominates homeostatic control of sleep length and prior wake length in humans. Sleep. 1986 Jun; 9(2):353-64. PMID: 3505735.
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  229. Moline ML, Monk TH, Wagner DR, Pollak CP, Kream J, Fookson JE, Weitzman ED, Czeisler CA. Human growth hormone release is decreased during sleep in temporal isolation (free-running). Chronobiologia. 1986 Jan-Mar; 13(1):13-9. PMID: 3720426.
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  230. Muller JE, Stone PH, Turi ZG, Rutherford JD, Czeisler CA, Parker C, Poole WK, Passamani E, Roberts R, Robertson T, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med. 1985 Nov 21; 313(21):1315-22. PMID: 2865677.
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  231. Richardson GS, Moore-Ede MC, Czeisler CA, Dement WC. Circadian rhythms of sleep and wakefulness in mice: analysis using long-term automated recording of sleep. Am J Physiol. 1985 Mar; 248(3 Pt 2):R320-30. PMID: 3838419.
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  232. Gander PH, Kronauer RE, Czeisler CA, Moore-Ede MC. Simulating the action of zeitgebers on a coupled two-oscillator model of the human circadian system. Am J Physiol. 1984 Sep; 247(3 Pt 2):R418-26. PMID: 6476142.
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  233. Gander PH, Kronauer RE, Czeisler CA, Moore-Ede MC. Modeling the action of zeitgebers on the human circadian system: comparisons of simulations and data. Am J Physiol. 1984 Sep; 247(3 Pt 2):R427-44. PMID: 6476143.
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  234. Moore-Ede MC, Czeisler CA, Richardson GS. Circadian timekeeping in health and disease. Part 2. Clinical implications of circadian rhythmicity. N Engl J Med. 1983 Sep 01; 309(9):530-6. PMID: 6348546.
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  235. Moore-Ede MC, Czeisler CA, Richardson GS. Circadian timekeeping in health and disease. Part 1. Basic properties of circadian pacemakers. N Engl J Med. 1983 Aug 25; 309(8):469-76. PMID: 6348541.
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  236. Weitzman ED, Zimmerman JC, Czeisler CA, Ronda J. Cortisol secretion is inhibited during sleep in normal man. J Clin Endocrinol Metab. 1983 Feb; 56(2):352-8. PMID: 6822642.
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  237. Czeisler CA, Moore-Ede MC, Coleman RH. Rotating shift work schedules that disrupt sleep are improved by applying circadian principles. Science. 1982 Jul 30; 217(4558):460-3. PMID: 7089576.
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  238. Weitzman ED, Moline ML, Czeisler CA, Zimmerman JC. Chronobiology of aging: temperature, sleep-wake rhythms and entrainment. Neurobiol Aging. 1982; 3(4):299-309. PMID: 7170047.
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  239. Guilleminault C, Czeisler C, Coleman R, Miles L. Circadian rhythm disturbances and sleep disorders in shift workers. Electroencephalogr Clin Neurophysiol Suppl. 1982; 36:709-14. PMID: 6962057.
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  240. Kronauer RE, Czeisler CA, Pilato SF, Moore-Ede MC, Weitzman ED. Mathematical model of the human circadian system with two interacting oscillators. Am J Physiol. 1982 Jan; 242(1):R3-17. PMID: 7058927.
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  241. Bernstein IL, Zimmerman JC, Czeisler CA, Weitzman ED. Meal patterns in "free-running" humans. Physiol Behav. 1981 Oct; 27(4):621-3. PMID: 7323164.
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  242. Czeisler CA, Richardson GS, Zimmerman JC, Moore-Ede MC, Weitzman ED. Entrainment of human circadian rhythms by light-dark cycles: a reassessment. Photochem Photobiol. 1981 Aug; 34(2):239-47. PMID: 7267730.
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  243. Weitzman ED, Czeisler CA, Coleman RM, Spielman AJ, Zimmerman JC, Dement W, Richardson G, Pollak CP. Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia. Arch Gen Psychiatry. 1981 Jul; 38(7):737-46. PMID: 7247637.
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  244. Weitzman ED, Czeisler CA, Zimmerman JC, Moore-Ede MC. Biological rhythms in man: relationship of sleep-wake, cortisol, growth hormone, and temperature during temporal isolation. Adv Biochem Psychopharmacol. 1981; 28:475-99. PMID: 7010946.
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  245. Czeisler CA, Richardson GS, Coleman RM, Zimmerman JC, Moore-Ede MC, Dement WC, Weitzman ED. Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia. Sleep. 1981; 4(1):1-21. PMID: 7232967.
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  246. Czeisler CA, Weitzman Ed, Moore-Ede MC, Zimmerman JC, Knauer RS. Human sleep: its duration and organization depend on its circadian phase. Science. 1980 Dec 12; 210(4475):1264-7. PMID: 7434029.
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  247. Lydic R, Schoene WC, Czeisler CA, Moore-Ede MC. Suprachiasmatic region of the human hypothalamus: homolog to the primate circadian pacemaker? Sleep. 1980; 2(3):355-61. PMID: 6773133.
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  248. Weitzman ED, Czeisler CA, Zimmerman JC, Ronda JM. Timing of REM and stages 3 + 4 sleep during temporal isolation in man. Sleep. 1980; 2(4):391-407. PMID: 7403740.
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  249. Zimmerman JC, Czeisler CA, Laxminarayan S, Knauer RS, Weitzman ED. REM density is dissociated from REM sleep timing during free-running sleep episodes. Sleep. 1980; 2(4):409-15. PMID: 7403741.
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  250. Weitzman ED, Czeisler CA, Zimmerman JC, Moore-Ede MC, Ronda JM. Sleep duration, sleep stages and waking time are related to circadian phase in young and older men during nonentrained conditions. Trans Am Neurol Assoc. 1980; 105:371-4. PMID: 7348985.
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  251. Czeisler CA, Zimmerman JC, Ronda JM, Moore-Ede MC, Weitzman ED. Timing of REM sleep is coupled to the circadian rhythm of body temperature in man. Sleep. 1980; 2(3):329-46. PMID: 7403736.
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  252. Czeisler CA, Guilleminault C. 250 years ago: tribute to a new discipline (1729--1979). Sleep. 1979; 2(2):155-60. PMID: 397600.
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  253. Weitzman ED, Weinberg U, D'Eletto R, Lynch H, Wurtman RJ, Czeisler C, Erlich S. Studies of the 24 hour rhythm of melatonin in man. J Neural Transm Suppl. 1978; (13):325-37. PMID: 288856.
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  254. Kokkoris CP, Weitzman ED, Pollak CP, Spielman AJ, Czeisler CA, Bradlow H. Long-term ambulatory temperature monitoring in a subject with a hypernychthemeral sleep--wake cycle disturbance. Sleep. 1978; 1(2):177-90. PMID: 756061.
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  255. Czeisler CA, Ede MC, Regestein QR, Kisch ES, Fang VS, Ehrlich EN. Episodic 24-hour cortisol secretory patterns in patients awaiting elective cardiac surgery. J Clin Endocrinol Metab. 1976 Feb; 42(2):273-83. PMID: 1262431.
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