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profileWarren Myron Zapol, M.D.

TitleReginald Jenney Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anaesthesia & Critical Care, Thier 503
55 Fruit St
Boston MA 02114
Phone617/726-3030
Fax617/643-5767
vCardDownload vCard (login for email)
Other Positions
TitleMember of the Faculty of the Harvard-MIT Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL042397     (ZAPOL, WARREN MYRON)Jul 1, 1990 - Jul 31, 2009
NIH/NHLBI
Inhaled nitric oxide
Role: Principal Investigator

P50HL023591     (ZAPOL, WARREN MYRON)Sep 30, 1978 - May 31, 1989
NIH/NHLBI
SCOR: ADULT RESPIRATORY FAILURE
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats. Shock. 2017 Jun; 47(6):735-742. PMID: 27861257.
    View in: PubMed
  2. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Chen KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 May 23; 114(21):E4241-E4250. PMID: 28483998.
    View in: PubMed
  3. Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM. Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. Am J Physiol Heart Circ Physiol. 2017 Jun 01; 312(6):H1120-H1127. PMID: 28314763.
    View in: PubMed
  4. Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1213-L1221. PMID: 27815261.
    View in: PubMed
  5. Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM. Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 Nov 01; 194(9):1168-1170. PMID: 27797618.
    View in: PubMed
  6. Muenster S, Beloiartsev A, Yu B, Du E, Abidi S, Dao M, Fabry G, Graw JA, Wepler M, Malhotra R, Fernandez BO, Feelisch M, Bloch KD, Bloch DB, Zapol WM. Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension. Anesthesiology. 2016 Nov; 125(5):952-963. PMID: 27517645.
    View in: PubMed
  7. Yu B, Blaesi AH, Casey N, Raykhtsaum G, Zazzeron L, Jones R, Morrese A, Dobrynin D, Malhotra R, Bloch DB, Goldstein LE, Zapol WM. Detection and removal of impurities in nitric oxide generated from air by pulsed electrical discharge. Nitric Oxide. 2016 Nov 30; 60:16-23. PMID: 27592386.
    View in: PubMed
  8. Graw JA, Mayeur C, Rosales I, Liu Y, Sabbisetti VS, Riley FE, Rechester O, Malhotra R, Warren HS, Colvin RB, Bonventre JV, Bloch DB, Zapol WM. Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells. Circulation. 2016 Sep 27; 134(13):945-60. PMID: 27515135; PMCID: PMC5039096 [Available on 09/27/17].
  9. Rezoagli E, Ichinose F, Strelow S, Roy N, Shelton K, Matsumine R, Chen L, Bittner EA, Bloch DB, Zapol WM, Berra L. Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis. J Cardiothorac Vasc Anesth. 2017 Apr; 31(2):505-515. PMID: 27590461.
    View in: PubMed
  10. Trahanas JM, Kolobow MA, Hardy MA, Berra L, Zapol WM, Bartlett RH. "Treating Lungs": The Scientific Contributions of Dr. Theodor Kolobow. ASAIO J. 2016 Mar-Apr; 62(2):203-10. PMID: 26720733; PMCID: PMC4790827 [Available on 03/01/17].
  11. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. PMID: 26917594; PMCID: PMC4860742 [Available on 10/01/16].
  12. Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2016 Apr 15; 310(8):H984-94. PMID: 26873969; PMCID: PMC4867336 [Available on 04/15/17].
  13. Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2015 Nov 15; 192(10):1191-9. PMID: 26214119; PMCID: PMC4731621 [Available on 11/15/16].
  14. Mwanga-Amumpaire J, Carroll RW, Baudin E, Kemigisha E, Nampijja D, Mworozi K, Santorino D, Nyehangane D, Nathan DI, De Beaudrap P, Etard JF, Feelisch M, Fernandez BO, Berssenbrugge A, Bangsberg D, Bloch KD, Boum Y, Zapol WM. Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial. Open Forum Infect Dis. 2015 Sep; 2(3):ofv111. PMID: 26309894; PMCID: PMC4542141.
  15. Yu B, Muenster S, Blaesi AH, Bloch DB, Zapol WM. Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy. Sci Transl Med. 2015 Jul 01; 7(294):294ra107. PMID: 26136478.
    View in: PubMed
  16. Beloiartsev A, da Glória Rodrigues-Machado M, Zhou GL, Tan TC, Zazzeron L, Tainsh RE, Leyton P, Jones RC, Scherrer-Crosbie M, Zapol WM. Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j. Am J Respir Cell Mol Biol. 2015 May; 52(5):563-70. PMID: 25233285; PMCID: PMC4491134.
  17. Berra L, Pinciroli R, Stowell CP, Wang L, Yu B, Fernandez BO, Feelisch M, Mietto C, Hod EA, Chipman D, Scherrer-Crosbie M, Bloch KD, Zapol WM. Autologous transfusion of stored red blood cells increases pulmonary artery pressure. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):800-7. PMID: 25162920; PMCID: PMC4299609.
  18. Rossaint R, Lewandowski K, Zapol WM. Our paper 20 years later: Inhaled nitric oxide for the acute respiratory distress syndrome--discovery, current understanding, and focussed targets of future applications. Intensive Care Med. 2014 Nov; 40(11):1649-58. PMID: 25201565.
    View in: PubMed
  19. Nakagawa A, Lui FE, Wassaf D, Yefidoff-Freedman R, Casalena D, Palmer MA, Meadows J, Mozzarelli A, Ronda L, Abdulmalik O, Bloch KD, Safo MK, Zapol WM. Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. ACS Chem Biol. 2014 Oct 17; 9(10):2318-25. PMID: 25061917; PMCID: PMC4205001.
  20. Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD. Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia. PLoS Genet. 2013 Nov; 9(11):e1003950. PMID: 24278032; PMCID: PMC3836722.
  21. Baron DM, Beloiartsev A, Nakagawa A, Martyn T, Stowell CP, Malhotra R, Mayeur C, Bloch KD, Zapol WM. Adverse effects of hemorrhagic shock resuscitation with stored blood are ameliorated by inhaled nitric oxide in lambs*. Crit Care Med. 2013 Nov; 41(11):2492-501. PMID: 23887236; PMCID: PMC3812272.
  22. Beloiartsev A, Baron DM, Yu B, Bloch KD, Zapol WM. Hemoglobin infusion does not alter murine pulmonary vascular tone. Nitric Oxide. 2013 Apr 01; 30:1-8. PMID: 23313572; PMCID: PMC3764648.
  23. Lei C, Yu B, Shahid M, Beloiartsev A, Bloch KD, Zapol WM. Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock. Anesthesiology. 2012 Dec; 117(6):1190-202. PMID: 23168426; PMCID: PMC3852861.
  24. Bergmark B, Bergmark R, Beaudrap PD, Boum Y, Mwanga-Amumpaire J, Carroll R, Zapol W. Inhaled nitric oxide and cerebral malaria: basis of a strategy for buying time for pharmacotherapy. Pediatr Infect Dis J. 2012 Dec; 31(12):e250-4. PMID: 22760538.
    View in: PubMed
  25. Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology. 2012 Jul; 117(1):56-63. PMID: 22531338; PMCID: PMC3980575.
  26. Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD, Iliopoulos D. Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 01; 303(3):L199-207. PMID: 22659882; PMCID: PMC3423863.
  27. Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology. 2012 Mar; 116(3):637-47. PMID: 22293717; PMCID: PMC3293704.
  28. Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM. Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion. 2012 Jul; 52(7):1410-22. PMID: 22233290; PMCID: PMC3794463.
  29. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22. PMID: 22223731; PMCID: PMC3679546.
  30. Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One. 2011; 6(11):e27714. PMID: 22110737; PMCID: PMC3218025.
  31. Lui FE, Yu B, Baron DM, Lei C, Zapol WM, Kluger R. Hemodynamic responses to a hemoglobin bis-tetramer and its polyethylene glycol conjugate. Transfusion. 2012 May; 52(5):974-82. PMID: 22070638.
    View in: PubMed
  32. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM. Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov; 115(5):1012-21. PMID: 21912243; PMCID: PMC3752661.
  33. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11. PMID: 21934409; PMCID: PMC3194098.
  34. Jiang Y, Bao FP, Liang Y, Kimball WR, Liu Y, Zapol WM, Kacmarek RM. Effectiveness of breathing through nasal and oral routes in unconscious apneic adult human subjects: a prospective randomized crossover trial. Anesthesiology. 2011 Jul; 115(1):129-35. PMID: 21572315.
    View in: PubMed
  35. Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011 Oct 30; 25(3):294-302. PMID: 21642009; PMCID: PMC3466086.
  36. Zapol WM. Life at the frontier: the third annual John W. Severinghaus lecture on translational science. Anesthesiology. 2011 Apr; 114(4):771-81. PMID: 21358318.
    View in: PubMed
  37. Derwall M, Francis RC, Kida K, Bougaki M, Crimi E, Adrie C, Zapol WM, Ichinose F. Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects. Crit Care. 2011; 15(1):R51. PMID: 21299857; PMCID: PMC3221981.
  38. Nagasaka Y, Buys ES, Spagnolli E, Steinbicker AU, Hayton SR, Rauwerdink KM, Brouckaert P, Zapol WM, Bloch KD. Soluble guanylate cyclase-a1 is required for the cardioprotective effects of inhaled nitric oxide. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1477-83. PMID: 21257915; PMCID: PMC3075043.
  39. Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. Hypertension. 2010 Oct; 56(4):705-12. PMID: 20713914; PMCID: PMC3157252.
  40. Vaporidi K, Francis RC, Bloch KD, Zapol WM. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L150-9. PMID: 20453164; PMCID: PMC2928605.
  41. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar; 112(3):586-94. PMID: 20179495; PMCID: PMC2829726.
  42. Yu B, Bloch KD, Zapol WM. Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med. 2009 Apr; 19(3):103-7. PMID: 19679268; PMCID: PMC2756450.
  43. Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan; 110(1):113-22. PMID: 19104178; PMCID: PMC2704389.
  44. Nagasaka Y, Fernandez BO, Garcia-Saura MF, Petersen B, Ichinose F, Bloch KD, Feelisch M, Zapol WM. Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology. 2008 Oct; 109(4):675-82. PMID: 18813047; PMCID: PMC2632955.
  45. Kitch BT, Cooper JB, Zapol WM, Marder JE, Karson A, Hutter M, Campbell EG. Handoffs causing patient harm: a survey of medical and surgical house staff. Jt Comm J Qual Patient Saf. 2008 Oct; 34(10):563-70. PMID: 18947116.
    View in: PubMed
  46. Fitzsimons MG, Baker KH, Lowenstein E, Zapol WM. Random drug testing to reduce the incidence of addiction in anesthesia residents: preliminary results from one program. Anesth Analg. 2008 Aug; 107(2):630-5. PMID: 18633044.
    View in: PubMed
  47. Liang Y, Kimball WR, Kacmarek RM, Zapol WM, Jiang Y. Nasal ventilation is more effective than combined oral-nasal ventilation during induction of general anesthesia in adult subjects. Anesthesiology. 2008 Jun; 108(6):998-1003. PMID: 18497599.
    View in: PubMed
  48. Falke KJ, Busch T, Hoffmann O, Liggins GC, Liggins J, Mohnhaupt R, Roberts JD, Stanek K, Zapol WM. Breathing pattern, CO2 elimination and the absence of exhaled NO in freely diving Weddell seals. Respir Physiol Neurobiol. 2008 Jun 30; 162(1):85-92. PMID: 18534926.
    View in: PubMed
  49. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90. PMID: 18391111; PMCID: PMC2733227.
  50. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68. PMID: 18362598; PMCID: PMC2838418.
  51. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8. PMID: 18055842.
    View in: PubMed
  52. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. PMID: 17872487; PMCID: PMC2176100.
  53. Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM. Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1300-5. PMID: 17720871.
    View in: PubMed
  54. Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH, Scherrer-Crosbie M. In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation. 2007 Sep 11; 116(11):1250-7. PMID: 17709634.
    View in: PubMed
  55. Bloch KD, Ichinose F, Roberts JD, Zapol WM. Inhaled NO as a therapeutic agent. Cardiovasc Res. 2007 Jul 15; 75(2):339-48. PMID: 17544387; PMCID: PMC1986790.
  56. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H620-7. PMID: 17416602.
    View in: PubMed
  57. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    View in: PubMed
  58. Zapol W. A vision for International Polar year 2007-2008. Alaska Med. 2007; 49(2 Suppl):8-10. PMID: 17929598.
    View in: PubMed
  59. Jiang Y, Wain JC, Chang AW, Zapol WM, Xie Z. Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery. Anesth Analg. 2006 Aug; 103(2):312-5, table of contents. PMID: 16861410.
    View in: PubMed
  60. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84. PMID: 16443673.
    View in: PubMed
  61. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Inhaled nitric oxide does not reduce systemic vascular resistance in mice. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1826-9. PMID: 16299267.
    View in: PubMed
  62. Evgenov OV, Busch CJ, Evgenov NV, Liu R, Petersen B, Falkowski GE, Petho B, Vas A, Bloch KD, Zapol WM, Ichinose F. Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L723-L729. PMID: 16284211.
    View in: PubMed
  63. Falkowski PG, Katz ME, Milligan AJ, Fennel K, Cramer BS, Aubry MP, Berner RA, Novacek MJ, Zapol WM. The rise of oxygen over the past 205 million years and the evolution of large placental mammals. Science. 2005 Sep 30; 309(5744):2202-4. PMID: 16195457.
    View in: PubMed
  64. Lepore JJ, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1950-6. PMID: 16297803.
    View in: PubMed
  65. Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):334-43. PMID: 15894604; PMCID: PMC2718472.
  66. Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005 May; 127(5):1647-53. PMID: 15888841.
    View in: PubMed
  67. Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 2004 Oct 12; 110(15):2253-9. PMID: 15466650.
    View in: PubMed
  68. Zapol WM. Clifford J. Woolf, M.B., B,Ch., Ph.D. Recipient of the 2004 Excellence in Research Award. Anesthesiology. 2004 Oct; 101(4):820-3. PMID: 15461984.
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  69. Inglessis I, Shin JT, Lepore JJ, Palacios IF, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock. J Am Coll Cardiol. 2004 Aug 18; 44(4):793-8. PMID: 15312861.
    View in: PubMed
  70. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7. PMID: 15286002.
    View in: PubMed
  71. Ichinose F, Roberts JD, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29; 109(25):3106-11. PMID: 15226227.
    View in: PubMed
  72. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2524-30. PMID: 12907425.
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  73. Baboolal HA, Ichinose F, Ullrich R, Kawai N, Bloch KD, Zapol WM. Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice. Anesthesiology. 2002 Nov; 97(5):1227-33. PMID: 12411809.
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  74. Hataishi R, Kobayashi H, Takahashi Y, Hirano S, Zapol WM, Jones RC. Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats. Anesthesiology. 2002 Oct; 97(4):887-95. PMID: 12357155.
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  75. Lepore JJ, Maroo A, Pereira NL, Ginns LC, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol. 2002 Sep 15; 90(6):677-80. PMID: 12231108.
    View in: PubMed
  76. Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest. 2002 Jun; 109(11):1493-500. PMID: 12045263; PMCID: PMC150993.
  77. Raveh Y, Ichinose F, Orbach P, Bloch KD, Zapol WM. Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 2002 Apr; 96(4):926-33. PMID: 11964601.
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  78. Scherrer-Crosbie M, Ullrich R, Bloch KD, Nakajima H, Nasseri B, Aretz HT, Lindsey ML, Vançon AC, Huang PL, Lee RT, Zapol WM, Picard MH. Endothelial nitric oxide synthase limits left ventricular remodeling after myocardial infarction in mice. Circulation. 2001 Sep 11; 104(11):1286-91. PMID: 11551881.
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  79. Scherrer-Crosbie M, Streckenbach SC, Zapol WM. Acute cor pulmonale in acute respiratory distress syndrome: a dreaded complication of the past? Crit Care Med. 2001 Aug; 29(8):1641-2. PMID: 11505150.
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  80. Schmidt U, Han RO, DiSalvo TG, Guerrero JL, Gold HK, Zapol WM, Bloch KD, Semigran MJ. Cessation of platelet-mediated cyclic canine coronary occlusion after thrombolysis by combining nitric oxide inhalation with phosphodiesterase-5 inhibition. J Am Coll Cardiol. 2001 Jun 01; 37(7):1981-8. PMID: 11401142.
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  103. Sanchez LS, de la Monte SM, Filippov G, Jones RC, Zapol WM, Bloch KD. Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res. 1998 Feb; 43(2):163-8. PMID: 9475279.
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  112. Saavedra JE, Southan GJ, Davies KM, Lundell A, Markou C, Hanson SR, Adrie C, Hurford WE, Zapol WM, Keefer LK. Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J Med Chem. 1996 Oct 25; 39(22):4361-5. PMID: 8893830.
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  114. Bigatello LM, Zapol WM. New approaches to acute lung injury. Br J Anaesth. 1996 Jul; 77(1):99-109. PMID: 8703635.
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  116. Lee JS, Adrie C, Jacob HJ, Roberts JD, Zapol WM, Bloch KD. Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res. 1996 Feb; 78(2):337-42. PMID: 8575078.
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  117. Hurford WE, Hochachka PW, Schneider RC, Guyton GP, Stanek KS, Zapol DG, Liggins GC, Zapol WM. Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. J Appl Physiol (1985). 1996 Jan; 80(1):298-306. PMID: 8847318.
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  123. Kurrek MM, Castillo L, Bloch KD, Tannenbaum SR, Zapol WM. Inhaled nitric oxide does not alter endotoxin-induced nitric oxide synthase activity during rat lung perfusion. J Appl Physiol (1985). 1995 Oct; 79(4):1088-92. PMID: 8567547.
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  124. Ichinose F, Huang PL, Zapol WM. Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology. 1995 Jul; 83(1):101-8. PMID: 7541615.
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  125. Kawai N, Bloch DB, Filippov G, Rabkina D, Suen HC, Losty PD, Janssens SP, Zapol WM, de la Monte S, Bloch KD. Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol. 1995 Apr; 268(4 Pt 1):L589-95. PMID: 7537461.
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  126. Ichinose F, Adrie C, Hurford WE, Zapol WM. Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs. J Appl Physiol (1985). 1995 Apr; 78(4):1288-95. PMID: 7615435.
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  127. Staples JF, Zapol WM, Bloch KD, Kawai N, Val VM, Hochachka PW. Nitric oxide responses of air-breathing and water-breathing fish. Am J Physiol. 1995 Mar; 268(3 Pt 2):R816-9. PMID: 7535013.
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  128. Roberts JD, Roberts CT, Jones RC, Zapol WM, Bloch KD. Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res. 1995 Feb; 76(2):215-22. PMID: 7834832.
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  129. Kurrek MM, Winkler M, Robinson DR, Zapol WM. Platelet factor 4 injection produces acute pulmonary hypertension in the awake lamb. Anesthesiology. 1995 Jan; 82(1):183-7; discussion 31A. PMID: 7832299.
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  133. Zapol WM, Rimar S, Gillis N, Marletta M, Bosken CH. Nitric oxide and the lung. Am J Respir Crit Care Med. 1994 May; 149(5):1375-80. PMID: 8173780.
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  134. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD, Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology. 1994 Apr; 80(4):761-70. PMID: 8024129.
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  135. Fratacci MD, Kimball WR, Wain JC, Greene EM, Zapol WM. Effects of digoxin on regional diaphragm function after thoracotomy in awake sheep. Respir Physiol. 1994 Mar; 95(3):259-71. PMID: 8059071.
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  140. Shimouchi A, Janssens SP, Bloch DB, Zapol WM, Bloch KD. cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts. Am J Physiol. 1993 Nov; 265(5 Pt 1):L456-61. PMID: 7694505.
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  141. Liggins GC, France JT, Schneider RC, Knox BS, Zapol WM. Concentrations, metabolic clearance rates, production rates and plasma binding of cortisol in Antarctic phocid seals. Acta Endocrinol (Copenh). 1993 Oct; 129(4):356-9. PMID: 8237255.
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  142. Polaner DM, Kimball WR, Fratacci MD, Wain JC, Zapol WM. Thoracic epidural anesthesia increases diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology. 1993 Oct; 79(4):808-16. PMID: 8214761.
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  143. Fratacci MD, Kimball WR, Wain JC, Kacmarek RM, Polaner DM, Zapol WM. Diaphragmatic shortening after thoracic surgery in humans. Effects of mechanical ventilation and thoracic epidural anesthesia. Anesthesiology. 1993 Oct; 79(4):654-65. PMID: 8214744.
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  144. Montalescot G, Fischman AJ, Strauss HW, Wilkinson RA, Ahmad M, Fitzgibbon C, Robinson DW, Zapol WM. Imaging the ovine heparin-protamine interaction with 111In-protamine. J Appl Physiol (1985). 1993 Aug; 75(2):963-71. PMID: 8226502.
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  146. Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology. 1993 Mar; 78(3):427-35. PMID: 8457043.
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  147. Rossaint R, Falke KJ, López F, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med. 1993 Feb 11; 328(6):399-405. PMID: 8357359.
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  148. Roberts JD, Chen TY, Kawai N, Wain J, Dupuy P, Shimouchi A, Bloch K, Polaner D, Zapol WM. Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res. 1993 Feb; 72(2):246-54. PMID: 8380356.
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  149. Torres A, Kacmarek RM, Kimball WR, Qvist J, Stanek K, Whyte R, Zapol WM. Regional diaphragmatic length and EMG activity during inspiratory pressure support and CPAP in awake sheep. J Appl Physiol (1985). 1993 Feb; 74(2):695-703. PMID: 8458784.
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  154. Radermacher P, Falke KJ, Park YS, Ahn DW, Hong SK, Qvist J, Zapol WM. Nitrogen tensions in brachial vein blood of Korean ama divers. J Appl Physiol (1985). 1992 Dec; 73(6):2592-5. PMID: 1490974.
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  156. Zapol WM. Volotrauma and the intravenous oxygenator in patients with adult respiratory distress syndrome. Anesthesiology. 1992 Nov; 77(5):847-9. PMID: 1443735.
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  157. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet. 1992 Oct 03; 340(8823):818-9. PMID: 1357245.
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  158. Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM. Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest. 1992 Aug; 90(2):421-8. PMID: 1644915; PMCID: PMC443117.
  159. Polaner DM, Kimball WR, Fratacci MD, Wain JC, Torres A, Kacmarek RM, Zapol WM. Effects of aminophylline on regional diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology. 1992 Jul; 77(1):93-100. PMID: 1610014.
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  160. Warren HS, Glennon ML, Wainwright N, Amato SF, Black KM, Kirsch SJ, Riveau GR, Whyte RI, Zapol WM, Novitsky TJ. Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor. Infect Immun. 1992 Jun; 60(6):2506-13. PMID: 1587618; PMCID: PMC257189.
  161. Homma S, Jones R, Qvist J, Zapol WM, Reid L. Pulmonary vascular lesions in the adult respiratory distress syndrome caused by inhalation of zinc chloride smoke: a morphometric study. Hum Pathol. 1992 Jan; 23(1):45-50. PMID: 1544669.
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  162. Fratacci MD, Frostell CG, Chen TY, Wain JC, Robinson DR, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology. 1991 Dec; 75(6):990-9. PMID: 1741521.
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  163. Morel DR, Skoskiewicz M, Robinson DR, Bloch KJ, Hoaglin DC, Zapol WM. Leukotrienes, thromboxane A2, and prostaglandins during systemic anaphylaxis in sheep. Am J Physiol. 1991 Sep; 261(3 Pt 2):H782-92. PMID: 1716064.
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  164. Frostell C, Fratacci MD, Wain JC, Jones R, Zapol WM. Inhaled nitric oxide. A selective pulmonary vasodilator reversing hypoxic pulmonary vasoconstriction. Circulation. 1991 Jun; 83(6):2038-47. PMID: 2040056.
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  165. Hurford WE, Lynch KE, Strauss HW, Lowenstein E, Zapol WM. Myocardial perfusion as assessed by thallium-201 scintigraphy during the discontinuation of mechanical ventilation in ventilator-dependent patients. Anesthesiology. 1991 Jun; 74(6):1007-16. PMID: 2042755.
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  166. Zapol WM. A nordic ECMO saga or whither ECMO? Intensive Care Med. 1991; 17(2):69-70. PMID: 1865038.
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  168. Montalescot G, Zapol WM, Carvalho A, Robinson DR, Torres A, Lowenstein E. Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep. Circulation. 1990 Nov; 82(5):1754-64. PMID: 2171807.
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  176. Zapol WM, Hill RD, Qvist J, Falke K, Schneider RC, Liggins GC, Hochachka PW. Arterial gas tensions and hemoglobin concentrations of the freely diving Weddell seal. Undersea Biomed Res. 1989 Sep; 16(5):363-73. PMID: 2800051.
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  177. Kreil EA, Greene E, Fitzgibbon C, Robinson DR, Zapol WM. Effects of recombinant human tumor necrosis factor alpha, lymphotoxin, and Escherichia coli lipopolysaccharide on hemodynamics, lung microvascular permeability, and eicosanoid synthesis in anesthetized sheep. Circ Res. 1989 Aug; 65(2):502-14. PMID: 2665972.
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  179. Montalescot G, Kreil E, Lynch K, Greene EM, Torres A, Carvalho A, Fitzgibbon C, Robinson DR, Lowenstein E, Zapol WM. Effect of platelet depletion on lung vasoconstriction in heparin-protamine reactions. J Appl Physiol (1985). 1989 May; 66(5):2344-50. PMID: 2745299.
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  180. Teboul JL, Zapol WM, Brun-Buisson C, Abrouk F, Rauss A, Lemaire F. A comparison of pulmonary artery occlusion pressure and left ventricular end-diastolic pressure during mechanical ventilation with PEEP in patients with severe ARDS. Anesthesiology. 1989 Feb; 70(2):261-6. PMID: 2643895.
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  181. Zapol WM. Understanding images: correlation between computerized tomographic scans of lung structure with impaired function in ARDS. Anesthesiology. 1988 Dec; 69(6):812-4. PMID: 3057936.
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  182. Hochachka PW, Castellini JM, Hill RD, Schneider RC, Bengtson JL, Hill SE, Liggins GC, Zapol WM. Protective metabolic mechanisms during liver ischemia: transferable lessons from long-diving animals. Mol Cell Biochem. 1988 Nov; 84(1):77-85. PMID: 3231217.
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  183. Lemaire F, Teboul JL, Cinotti L, Giotto G, Abrouk F, Steg G, Macquin-Mavier I, Zapol WM. Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology. 1988 Aug; 69(2):171-9. PMID: 3044189.
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  184. Lichtenstein A, Eckhart WF, Swanson KJ, Vacanti CA, Zapol WM. Unplanned intraoperative and postoperative hemodilution: oxygen transport and consumption during severe anemia. Anesthesiology. 1988 Jul; 69(1):119-22. PMID: 3389548.
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  185. Morel DR, Lowenstein E, Nguyenduy T, Robinson DR, Repine JE, Chenoweth DE, Zapol WM. Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep. Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation. Circ Res. 1988 May; 62(5):905-15. PMID: 3129208.
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  186. Hurford WE, Zapol WM. The right ventricle and critical illness: a review of anatomy, physiology, and clinical evaluation of its function. Intensive Care Med. 1988; 14 Suppl 2:448-57. PMID: 3042829.
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  187. Zapol WM. A letter from Boston. Intensive Care Med. 1988; 14(2):178-9. PMID: 3361024.
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  188. Hjortsø E, Qvist J, Bud MI, Thomsen JL, Andersen JB, Wiberg-Jørgensen F, Jensen NK, Jones R, Reid LM, Zapol WM. ARDS after accidental inhalation of zinc chloride smoke. Intensive Care Med. 1988; 14(1):17-24. PMID: 3278025.
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  189. Hill RD, Schneider RC, Liggins GC, Schuette AH, Elliott RL, Guppy M, Hochachka PW, Qvist J, Falke KJ, Zapol WM. Heart rate and body temperature during free diving of Weddell seals. Am J Physiol. 1987 Aug; 253(2 Pt 2):R344-51. PMID: 3618833.
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  190. Zapol WM, Jones R. Vascular components of ARDS. Clinical pulmonary hemodynamics and morphology. Am Rev Respir Dis. 1987 Aug; 136(2):471-4. PMID: 3619211.
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  191. Carvalho AC, Quinn DA, DeMarinis SM, Beitz JG, Zapol WM. Platelet function in acute respiratory failure. Am J Hematol. 1987 Aug; 25(4):377-88. PMID: 2956879.
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  192. Whalen RL, Hurford WE, Skoskiewicz M, Wonders TR, Zapol WM. A new right ventricular assist device. The extracorporeal pulsatile assist device (EPAD). ASAIO Trans. 1987 Jul-Sep; 33(3):222-6. PMID: 3675948.
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  193. Zapol WM. Diving adaptations of the Weddell seal. Sci Am. 1987 Jun; 256(6):100-5. PMID: 3589643.
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  194. Morel DR, Huttemeier PC, Skoskiewicz MJ, Nguyenduy T, Melvin C, Robinson DR, Zapol WM. Dose-dependent effects of a pyridoquinazoline thromboxane synthetase inhibitor on arachidonic acid metabolites and hemodynamics during E. coli endotoxemia in anesthetized sheep. Prostaglandins. 1987 Jun; 33(6):879-902. PMID: 3118413.
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  195. Collee GG, Lynch KE, Hill RD, Zapol WM. Bedside measurement of pulmonary capillary pressure in patients with acute respiratory failure. Anesthesiology. 1987 May; 66(5):614-20. PMID: 3578875.
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  196. Morel DR, Zapol WM, Thomas SJ, Kitain EM, Robinson DR, Moss J, Chenoweth DE, Lowenstein E. C5a and thromboxane generation associated with pulmonary vaso- and broncho-constriction during protamine reversal of heparin. Anesthesiology. 1987 May; 66(5):597-604. PMID: 3495208.
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  197. Greene R, Lind S, Jantsch H, Wilson R, Lynch K, Jones R, Carvalho A, Reid L, Waltman AC, Zapol W. Pulmonary vascular obstruction in severe ARDS: angiographic alterations after i.v. fibrinolytic therapy. AJR Am J Roentgenol. 1987 Mar; 148(3):501-8. PMID: 3492876.
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  198. Quinn DA, Carvalho AC, Geller E, Khaw BA, Barlaikovach M, Zielonka J, Greene R, Strauss HW, Zapol WM. 99mTc-fibrinogen scanning in adult respiratory distress syndrome. Am Rev Respir Dis. 1987 Jan; 135(1):100-6. PMID: 3800138.
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  199. Michelassi F, Schuette A, Landa L, Zapol WM, Grillo HC. Pulmonary and systemic contribution to canine tracheobronchial blood flow. Ital J Surg Sci. 1987; 17(2):105-12. PMID: 3301739.
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  200. Qvist J, Hill RD, Schneider RC, Falke KJ, Liggins GC, Guppy M, Elliot RL, Hochachka PW, Zapol WM. Hemoglobin concentrations and blood gas tensions of free-diving Weddell seals. J Appl Physiol (1985). 1986 Oct; 61(4):1560-9. PMID: 3096941.
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  201. Robinson DR, Skoskiewicz M, Bloch KJ, Castorena G, Hayes E, Lowenstein E, Melvin C, Michelassi F, Zapol WM. Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. J Exp Med. 1986 Jun 01; 163(6):1509-17. PMID: 3011947; PMCID: PMC2188117.
  202. Jones R, Kirton OC, Zapol WM, Reid L. Rat pulmonary artery wall injury by chronic intermittent infusions of Escherichia coli endotoxin. Obliterative vasculitis and vascular occlusion. Lab Invest. 1986 Mar; 54(3):282-94. PMID: 3079547.
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  203. Guppy M, Hill RD, Schneider RC, Qvist J, Liggins GC, Zapol WM, Hochachka PW. Microcomputer-assisted metabolic studies of voluntary diving of Weddell seals. Am J Physiol. 1986 Feb; 250(2 Pt 2):R175-87. PMID: 3511736.
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  204. Jones R, Zapol WM, Reid L. Oxygen toxicity and restructuring of pulmonary arteries--a morphometric study. The response to 4 weeks' exposure to hyperoxia and return to breathing air. Am J Pathol. 1985 Nov; 121(2):212-23. PMID: 2932915; PMCID: PMC1888055.
  205. Falke KJ, Hill RD, Qvist J, Schneider RC, Guppy M, Liggins GC, Hochachka PW, Elliott RE, Zapol WM. Seal lungs collapse during free diving: evidence from arterial nitrogen tensions. Science. 1985 Aug 09; 229(4713):556-8. PMID: 4023700.
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  206. Jones R, Zapol WM, Reid L. Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol. 1984 Nov; 117(2):273-85. PMID: 6238536; PMCID: PMC1900440.
  207. Kirton OC, Jones R, Zapol WM, Reid L. The development of a model of subacute lung injury after intra-abdominal infection. Surgery. 1984 Aug; 96(2):384-94. PMID: 6379962.
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  208. Geller E, Khaw BA, Strauss HW, Carvalho AC, Rajagopalan B, Jones R, Zapol WM. Technetium-fibrinogen lung scanning in canine lung contusion. J Trauma. 1984 Jul; 24(7):611-8. PMID: 6748122.
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  209. Zapol WM, Wilson R, Hales C, Fish D, Castorena G, Hilgenberg A, Quinn D, Kradin R. Venovenous bypass with a membrane lung to support bilateral lung lavage. JAMA. 1984 Jun 22-29; 251(24):3269-71. PMID: 6727002.
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  210. Schuette AH, Hüttemeier PC, Hill RD, Watkins WD, Wonders TR, Kong D, Zapol WM. Regional blood flow and pulmonary thromboxane release after sublethal endotoxin infusion in sheep. Surgery. 1984 Apr; 95(4):444-53. PMID: 6369593.
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  211. Michelassi F, Castorena G, Hill RD, Lowenstein E, Watkins WD, Petkau AJ, Zapol WM. Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility. Surgery. 1983 Aug; 94(2):267-75. PMID: 6308844.
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  212. Tomashefski JF, Davies P, Boggis C, Greene R, Zapol WM, Reid LM. The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol. 1983 Jul; 112(1):112-26. PMID: 6859225; PMCID: PMC1916312.
  213. Jones R, Zapol WM, Reid L. Pulmonary arterial wall injury and remodelling by hyperoxia. Chest. 1983 May; 83(5 Suppl):40S-42S. PMID: 6839848.
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  214. Hüttemeier PC, Berry D, Bloch KJ, Watkins WD, Zapol WM. Pulmonary vasoconstriction and profound leukopenia in two sheep experimental models. Effects of complement depletion. Chest. 1983 May; 83(5 Suppl):24S-25S. PMID: 6340984.
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  215. Erdmann AJ, Hüttemeier PC, Landolt C, Zapol WM. Pure oxygen breathing increases sheep lung microvascular permeability. Anesthesiology. 1983 Feb; 58(2):153-8. PMID: 6824169.
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  216. Wonders T, Huttemeier P, Berry D, Schuette A, Kong D, Watkins WD, Zapol WM. Complement depletion prevents pulmonary hypertension and leukopenia in sheep extracorporeal membrane oxygenation. Trans Am Soc Artif Intern Organs. 1983; 29:210-4. PMID: 6673232.
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  217. Michelassi F, Landa L, Hill RD, Huttemeier P, Lowenstein E, Zapol WM, Watkins WD. Leukotriene D4: a potent sheep coronary vasoconstrictor not blocked by ibuprofen. Adv Prostaglandin Thromboxane Leukot Res. 1983; 11:397-9. PMID: 6221552.
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  218. Snow RL, Davies P, Pontoppidan H, Zapol WM, Reid L. Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Respir Dis. 1982 Nov; 126(5):887-92. PMID: 7149455.
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  219. Carvalho AC, Bellman SM, Saullo VJ, Quinn D, Zapol WM. Altered factor VIII in acute respiratory failure. N Engl J Med. 1982 Oct 28; 307(18):1113-9. PMID: 6214713.
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  220. Peterson MB, Huttemeier PC, Zapol WM, Martin EG, Watkins WD. Thromboxane mediates acute pulmonary hypertension in sheep extracorporeal perfusion. Am J Physiol. 1982 Sep; 243(3):H471-9. PMID: 7051860.
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  221. Michelassi F, Landa L, Hill RD, Lowenstein E, Watkins WD, Petkau AJ, Zapol WM. Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science. 1982 Aug 27; 217(4562):841-3. PMID: 6808665.
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  222. Hüttemeier PC, Watkins WD, Peterson MB, Zapol WM. Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. Circ Res. 1982 May; 50(5):688-94. PMID: 7042108.
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  223. Schuette AH, Hüttemeier PC, Watkins WD, Zapol WM. Effect of lung thromboxane generation on regional blood flow during sheep bypass. Am J Physiol. 1982 Mar; 242(3):H462-9. PMID: 7065206.
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  224. Murphy BJ, Hochachka PW, Zapol WM, Liggins GC. Free amino acids in the blood of fetal and maternal Weddell seals. Am J Physiol. 1982 Jan; 242(1):R85-8. PMID: 7058934.
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  225. Greene R, Zapol WM, Snider MT, Reid L, Snow R, O'Connell RS, Novelline RA. Early bedside detection of pulmonary vascular occlusion during acute respiratory failure. Am Rev Respir Dis. 1981 Nov; 124(5):593-601. PMID: 7305115.
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  226. Qvist J, Weber RE, Zapol WM. Oxygen equilibrium properties of blood and hemoglobin of fetal and adult Weddell seals. J Appl Physiol Respir Environ Exerc Physiol. 1981 May; 50(5):999-1005. PMID: 7228773.
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  227. Wonders TR, Southmayd JR, Schuette AH, Huttemeier PC, Kong D, Watkins WD, Carvalho A, Zapol WM. Reduced plasma thromboxane elevation during partial cardiopulmonary bypass in thrombocytopenic sheep. Trans Am Soc Artif Intern Organs. 1981; 27:276-9. PMID: 7331082.
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  228. Liggins GC, Qvist J, Hochachka PW, Murphy BJ, Creasy RK, Schneider RC, Snider MT, Zapol WM. Fetal cardiovascular and metabolic responses to simulated diving in the Weddell seal. J Appl Physiol Respir Environ Exerc Physiol. 1980 Sep; 49(3):424-30. PMID: 7204165.
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  229. Schneider RC, Zapol WM, Carvalho AC. Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis. 1980 Sep; 122(3):445-51. PMID: 7416620.
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  230. Zapol WM, Snider MT. Membrane lungs for acute respiratory failure: current status. Am Rev Respir Dis. 1980 Jun; 121(6):907-9. PMID: 6998335.
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  231. Murphy B, Zapol WM, Hochachka PW. Metabolic activities of heart, lung, and brain during diving and recovery in the Weddell seal. J Appl Physiol Respir Environ Exerc Physiol. 1980 Apr; 48(4):596-605. PMID: 7380685.
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  232. Zapol WM, Peterson MB, Wonders TR, Kong D, Watkins WD. Plasma thromboxane and prostacyclin metabolites in sheep partial cardiopulmonary bypass. Trans Am Soc Artif Intern Organs. 1980; 26:556-60. PMID: 7018060.
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  233. Zapol WM, Snider MT, Hill JD, Fallat RJ, Bartlett RH, Edmunds LH, Morris AH, Peirce EC, Thomas AN, Proctor HJ, Drinker PA, Pratt PC, Bagniewski A, Miller RG. Extracorporeal membrane oxygenation in severe acute respiratory failure. A randomized prospective study. JAMA. 1979 Nov 16; 242(20):2193-6. PMID: 490805.
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  234. Zapol WM, Liggins GC, Schneider RC, Qvist J, Snider MT, Creasy RK, Hochachka PW. Regional blood flow during simulated diving in the conscious Weddell seal. J Appl Physiol Respir Environ Exerc Physiol. 1979 Nov; 47(5):968-73. PMID: 511722.
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  235. Zapol WM. What future for ECMO? Int J Artif Organs. 1979 Sep; 2(5):231-2. PMID: 478678.
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  236. Liggins GC, France JT, Knox BS, Zapol WM. High corticosteroid levels in plasma of adult and foetal Weddell seals (Leptonychotes weddelli). Acta Endocrinol (Copenh). 1979 Apr; 90(4):718-26. PMID: 433520.
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  237. Zapol WM, Trelstad RL, Coffey JW, Tsai I, Salvador RA. Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis. 1979 Apr; 119(4):547-54. PMID: 443627.
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  238. Hochachka PW, Murphy B, Liggins CG, Zapol W, Crensy R, Snider M, Schneider R, Quist J. Unusual maternal--fetal blood glucose concentrations in Weddell seal. Nature. 1979 Feb 01; 277(5695):388-9. PMID: 399322.
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  239. Delaney AG, Zapol WM, Erdmann AJ. Lung transvascular fluid dynamics with extracorporeal membrane oxygenation in unanesthetized lambs. J Thorac Cardiovasc Surg. 1979 Feb; 77(2):252-8. PMID: 762967.
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  240. Cooper JD, Richardson P, Kolobow T, Zapol W. Panel conference: prolonged respiratory support. Trans Am Soc Artif Intern Organs. 1979; 25:521-2. PMID: 524633.
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  241. Zapol WM. Membrane lung therapy of acute respiratory failure. Intensive Care Med. 1978 Nov; 4(4):171. PMID: 739074.
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  242. Delaney AG, Zapol WM, Erdmann AJ. Pulmonary transvascular fluid dynamics with extracorporeal membrane oxygenation in awake lambs. Surg Forum. 1978; 29:194-6. PMID: 401134.
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  243. Hochachka PW, Liggins GC, Qvist J, Schneider R, Snider MY, Wonders TR, Zapol WM. Pulmonary metabolism during diving: conditioning blood for the brain. Science. 1977 Nov 25; 198(4319):831-4. PMID: 918664.
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  244. Qvist J, Weber RE, DeVries AL, Zapol WM. pH and haemoglobin oxygen affinity in blood from the Antarctic cod Dissostichus mawsoni. J Exp Biol. 1977 Apr; 67:77-88. PMID: 19549.
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  245. Zapol WM, Snider MT, Schneider RC. Extracorporeal membrane oxygenation for acute respiratory failure. Anesthesiology. 1977 Apr; 46(4):272-85. PMID: 320912.
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  246. Zapol WM, Snider MT. Pulmonary hypertension in severe acute respiratory failure. N Engl J Med. 1977 Mar 03; 296(9):476-80. PMID: 834225.
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  247. Zapol WM, Kobayashi K, Snider MT, Greene R, Laver MB. Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure. Chest. 1977 Feb; 71(2 suppl):306-7. PMID: 836381.
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  248. Boucher R, Zapol WM, Snider M. Week long partial pulmonary bypass with an artificial lung pumped by the right ventricle. Trans Am Soc Artif Intern Organs. 1977; 23:448-55. PMID: 910367.
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  249. Liland AE, Zapol WM, Qvist J, Nash G, Skoskiewicz M, Pontoppidan H, Lowenstein E, Laver MB. Positive airway pressure in lambs spontaneously breathing air and oxygen. J Surg Res. 1976 Feb; 20(2):85-92. PMID: 768639.
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  250. Bloom SR, Snider MT, Petersen R, Wonders TR, Zapol WM. Platelet lifespan and gas exchange during perfusion with spiral coil membrane lungs coated with ethylcellulose perfluorobutyrate. Trans Am Soc Artif Intern Organs. 1976; 22:119-27. PMID: 951833.
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  251. Zapol WM, Schneider R, Snider M, Rie M. Partial bypass with membrane lungs for acute respiratory failure. Int Anesthesiol Clin. 1976; 14(1):119-33. PMID: 1262071.
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  252. McEnany MT, Zapol WM, Seebacher J, Skoskiewicz M, Schneider RC, Erdmann AJ, Snider MT, Kanarek DJ, Peck AG. Cannulation of the proximal aorta during long-term membrane lung perfusion. J Thorac Cardiovasc Surg. 1975 Oct; 70(4):631-43. PMID: 1177476.
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  253. Cooper JD, Duffin J, Zapol WM. Cannulation of ascending aorta for long-term membrane oxygenator support. J Thorac Cardiovasc Surg. 1975 Jun; 69(6):905-8. PMID: 1134116.
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  254. Zapol WM. Membrane lung perfusion for acute respiratory failure. Surg Clin North Am. 1975 Jun; 55(3):603-12. PMID: 1135749.
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  255. Zapol WM, Qvist J, Pontoppidan H, Liland A, McEnany T, Laver MB. Extracorporeal perfusion for acute respiratory failure: recent experience with the spiral coil membrane lung. J Thorac Cardiovasc Surg. 1975 Mar; 69(3):439-49. PMID: 1117737.
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  256. Ketteringham J, Zapol W, Birkett J, Nelsen L, Massucco A, Raith C. A high permeability, nonporpus, blood compatible membrane for membrane lungs: in vivo and in vitro performance. Trans Am Soc Artif Intern Organs. 1975; 21:224-33. PMID: 1145995.
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  257. Zapol WM, Bloom S, Carvalho A, Wonders T, Skoskiewicz M, Schneider R, Snider M. Improved platelet economy using filler free silicone rubber in long term membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1975; 21:587-92. PMID: 167494.
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  258. Kanarek D, Zapol W, Ahluwalia B, Qvist J, Hales C, Liland A. Radionuclide imaging of the circulatory distribution of membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1974; 20A:262-8. PMID: 4450346.
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  259. Bloom S, Zapol W, Wonders T, Berger S, Salzman E. Platelet destruction during 24 hour membrane lung perfusion. Trans Am Soc Artif Intern Organs. 1974; 20A:299-305. PMID: 4450351.
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  260. McCullough NJ, Falke K, Lowenstein E, Buckley MJ, Schmidt V, Zapol WM. Respiratory gas exchange with spiral coil membrane lungs: total cardiopulmonary bypass in adult sheep and clinical experience with long-term perfusion in adult patients. Mt Sinai J Med. 1973 Mar-Apr; 40(2):207-21. PMID: 4632734.
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  261. Ketteringham JM, Zapol WM, Gray DN, Stevenson KK, Massucco AA, Nelsen LL, Cullen DP. Polyalkylsulfone: a new polymer for membrane oxygenators. Trans Am Soc Artif Intern Organs. 1973; 19:61-5. PMID: 4722777.
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  262. Zapol WM, Kitz RJ. Buying time with artificial lungs. N Engl J Med. 1972 Mar 23; 286(12):657-8. PMID: 5060494.
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  263. Zapol W, Pontoppidan H, McCullough N, Schmidt V, Bland J, Kitz R. Clinical membrane lung support for acute respiratory insufficiency. Trans Am Soc Artif Intern Organs. 1972; 18(0):553-60, 562. PMID: 4679912.
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  264. Schmidt V, Zapol W, Prensky W, Wonders T, Wodinsky I, Kitz R. Continuous cancer chemotherapy: nitrosourea diffusion through implanted silicone rubber capsules. Trans Am Soc Artif Intern Organs. 1972; 18(0):45-53. PMID: 4679901.
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  265. Doppman JL, Zapol W, Pierce J. Transcatheter embolization with a silicone rubber preparation. Experimental observations. Invest Radiol. 1971 Sep-Oct; 6(5):304-9. PMID: 5112640.
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  266. Zapol WM, Kolobow T, Doppman J, Pierce JE. Response of ductus arteriosus and pulmonary blood flow to blood oxygen tension in immersed lamb fetuses perfused through an artificial placenta. J Thorac Cardiovasc Surg. 1971 Jun; 61(6):891-903. PMID: 5088579.
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  267. Kolobow T, Spragg RG, Pierce JE, Zapol WM. Extended term (to 16 days) partial extracorporeal blood gas exchange with the spiral membrane lung in unanesthetized lambs. Trans Am Soc Artif Intern Organs. 1971; 17:350-4. PMID: 5158116.
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  268. Kolobow T, Zapol WM, Sigman RL, Pierce J. Partial cardiopulmonary bypass lasting up to seven days in alert lambs with membrane lung blood oxygenation. J Thorac Cardiovasc Surg. 1970 Dec; 60(6):781-8. PMID: 5488068.
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  269. Kolobow T, Zapol W. A new thin-walled nonkinking catheter for peripheral vascular cannulation. Surgery. 1970 Oct; 68(4):625-9. PMID: 5473042.
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  270. Doppman JL, Zapol W, Kolobow T, Pierce J. Angiocardiography of fetal lambs on artificial placenta. Invest Radiol. 1970 May-Jun; 5(3):181-6. PMID: 5535759.
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  271. Zapol WM, Kolobow T, Pierce JEVUREK GG, Bowman RL. Artificial placenta: two days of total extrauterine support of the isolated premature lamb fetus. Science. 1969 Oct 31; 166(3905):617-8. PMID: 5823294.
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  272. Kolobow T, Zapol W, Pierce J. High survival and minimal blood damage in lambs exposed to long term (1 week) veno-venous pumping with a polyurethane chamber roller pump with and without a membrane blood oxygenator. Trans Am Soc Artif Intern Organs. 1969; 15:172-7. PMID: 5791384.
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  273. Kolobow T, Zapol W, Pierce JE, Keeley AF, Replogle RL, Haller A. Partial extracorporeal gas exchange in alert newborn lambs with a membrane artificial lung perfused via an A-V shunt for periods up to 96 hours. Trans Am Soc Artif Intern Organs. 1968; 14:328-34. PMID: 5701553.
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