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Warren Myron Zapol, M.D.

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  1. R01HL042397 (ZAPOL, WARREN MYRON) Jul 1, 1990 - Jul 31, 2009
    NIH/NHLBI
    Inhaled nitric oxide
    Role: Principal Investigator
  2. P50HL023591 (ZAPOL, WARREN MYRON) Sep 30, 1978 - May 31, 1989
    NIH/NHLBI
    SCOR: ADULT RESPIRATORY FAILURE
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zapol WM. Nitric Oxide Story. Anesthesiology. 2019 Mar; 130(3):435-440. PMID: 30664059.
    Citations:    Fields:    
  2. Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome. Am J Physiol Lung Cell Mol Physiol. 2019 Feb 01; 316(2):L391-L399. PMID: 30520688.
    Citations:    Fields:    
  3. Yu B, Ichinose F, Bloch DB, Zapol WM. Inhaled nitric oxide. Br J Pharmacol. 2019 Jan; 176(2):246-255. PMID: 30288739.
    Citations:    Fields:    
  4. Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R. Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation. Transfusion. 2019 Jan; 59(1):359-370. PMID: 30444016.
    Citations:    Fields:    
  5. Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, Hou L, Chen M, Chen W, Wang H, Zheng Q, Shen J, Jin Z, Chen T, Zhao R, Christie E, Sabbisetti VS, Nordio F, Bonventre JV, Xiong L, Zapol WM. Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery. Am J Respir Crit Care Med. 2018 Nov 15; 198(10):1279-1287. PMID: 29932345.
    Citations:    Fields:    
  6. Fitzsimons MG, Baker K, Malhotra R, Gottlieb A, Lowenstein E, Zapol WM. Reducing the Incidence of Substance Use Disorders in Anesthesiology Residents: 13 Years of Comprehensive Urine Drug Screening. Anesthesiology. 2018 Oct; 129(4):821-828. PMID: 30020101.
    Citations:    Fields:    
  7. Nagasaka Y, Fernandez BO, Steinbicker AU, Spagnolli E, Malhotra R, Bloch DB, Bloch KD, Zapol WM, Feelisch M. Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites. Nitric Oxide. 2018 11 01; 80:52-60. PMID: 30114529.
    Citations:    Fields:    
  8. Goldstein SR, Liu C, Safo MK, Nakagawa A, Zapol WM, Winkler JD. Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin. ACS Med Chem Lett. 2018 Jul 12; 9(7):714-718. PMID: 30034606.
    Citations:    
  9. Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm. 2018 05 07; 15(5):1954-1963. PMID: 29634905.
    Citations:    Fields:    
  10. Yu B, Ferrari M, Schleifer G, Blaesi AH, Wepler M, Zapol WM, Bloch DB. Development of a portable mini-generator to safely produce nitric oxide for the treatment of infants with pulmonary hypertension. Nitric Oxide. 2018 05 01; 75:70-76. PMID: 29486304.
    Citations:    Fields:    
  11. Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I. Pulmonary Delivery of Therapeutic and Diagnostic Gases. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):78-87. PMID: 29451844.
    Citations:    Fields:    
  12. Kassa T, Strader MB, Nakagawa A, Zapol WM, Alayash AI. Targeting ßCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects. Metallomics. 2017 09 20; 9(9):1260-1270. PMID: 28770911.
    Citations: 2     Fields:    Translation:HumansCells
  13. Ichinose F, Zapol WM. Inhaled Pulmonary Vasodilators in Cardiac Surgery Patients: Correct Answer Is "NO". Anesth Analg. 2017 08; 125(2):375-377. PMID: 28731972.
    Citations:    Fields:    Translation:Humans
  14. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. BMC Anesthesiol. 2017 06 14; 17(1):76. PMID: 28615047.
    Citations:    Fields:    Translation:Animals
  15. Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats. Shock. 2017 06; 47(6):735-742. PMID: 27861257.
    Citations:    Fields:    Translation:Animals
  16. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. PMID: 28483998.
    Citations: 5     Fields:    Translation:AnimalsCells
  17. Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM. Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. Am J Physiol Heart Circ Physiol. 2017 Jun 01; 312(6):H1120-H1127. PMID: 28314763.
    Citations: 2     Fields:    Translation:Animals
  18. Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1213-L1221. PMID: 27815261.
    Citations: 1     Fields:    
  19. Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM. Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 01; 194(9):1168-1170. PMID: 27797618.
    Citations: 1     Fields:    Translation:Humans
  20. Muenster S, Beloiartsev A, Yu B, Du E, Abidi S, Dao M, Fabry G, Graw JA, Wepler M, Malhotra R, Fernandez BO, Feelisch M, Bloch KD, Bloch DB, Zapol WM. Exposure of Stored Packed Erythrocytes to Nitric Oxide Prevents Transfusion-associated Pulmonary Hypertension. Anesthesiology. 2016 11; 125(5):952-963. PMID: 27517645.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Yu B, Blaesi AH, Casey N, Raykhtsaum G, Zazzeron L, Jones R, Morrese A, Dobrynin D, Malhotra R, Bloch DB, Goldstein LE, Zapol WM. Detection and removal of impurities in nitric oxide generated from air by pulsed electrical discharge. Nitric Oxide. 2016 11 30; 60:16-23. PMID: 27592386.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  22. Graw JA, Mayeur C, Rosales I, Liu Y, Sabbisetti VS, Riley FE, Rechester O, Malhotra R, Warren HS, Colvin RB, Bonventre JV, Bloch DB, Zapol WM. Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells. Circulation. 2016 09 27; 134(13):945-60. PMID: 27515135.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Rezoagli E, Ichinose F, Strelow S, Roy N, Shelton K, Matsumine R, Chen L, Bittner EA, Bloch DB, Zapol WM, Berra L. Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis. J Cardiothorac Vasc Anesth. 2017 Apr; 31(2):505-515. PMID: 27590461.
    Citations: 1     Fields:    Translation:Humans
  24. Trahanas JM, Kolobow MA, Hardy MA, Berra L, Zapol WM, Bartlett RH. "Treating Lungs": The Scientific Contributions of Dr. Theodor Kolobow. ASAIO J. 2016 Mar-Apr; 62(2):203-10. PMID: 26720733; PMCID: PMC4790827.
    Citations: 1     Fields:    Translation:Humans
  25. Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. PMID: 26917594; PMCID: PMC4860742.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  26. Shahid M, Spagnolli E, Ernande L, Thoonen R, Kolodziej SA, Leyton PA, Cheng J, Tainsh RE, Mayeur C, Rhee DK, Wu MX, Scherrer-Crosbie M, Buys ES, Zapol WM, Bloch KD, Bloch DB. BMP type I receptor ALK2 is required for angiotensin II-induced cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2016 Apr 15; 310(8):H984-94. PMID: 26873969; PMCID: PMC4867336.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning. Am J Respir Crit Care Med. 2015 Nov 15; 192(10):1191-9. PMID: 26214119; PMCID: PMC4731621.
    Citations: 5     Fields:    Translation:Animals
  28. Mwanga-Amumpaire J, Carroll RW, Baudin E, Kemigisha E, Nampijja D, Mworozi K, Santorino D, Nyehangane D, Nathan DI, De Beaudrap P, Etard JF, Feelisch M, Fernandez BO, Berssenbrugge A, Bangsberg D, Bloch KD, Boum Y, Zapol WM. Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial. Open Forum Infect Dis. 2015 Sep; 2(3):ofv111. PMID: 26309894; PMCID: PMC4542141.
    Citations: 5     
  29. Yu B, Muenster S, Blaesi AH, Bloch DB, Zapol WM. Producing nitric oxide by pulsed electrical discharge in air for portable inhalation therapy. Sci Transl Med. 2015 Jul 01; 7(294):294ra107. PMID: 26136478.
    Citations: 6     Fields:    Translation:Animals
  30. Beloiartsev A, da Glória Rodrigues-Machado M, Zhou GL, Tan TC, Zazzeron L, Tainsh RE, Leyton P, Jones RC, Scherrer-Crosbie M, Zapol WM. Pulmonary hypertension after prolonged hypoxic exposure in mice with a congenital deficiency of Cyp2j. Am J Respir Cell Mol Biol. 2015 May; 52(5):563-70. PMID: 25233285; PMCID: PMC4491134.
    Citations: 2     Fields:    Translation:Animals
  31. Berra L, Pinciroli R, Stowell CP, Wang L, Yu B, Fernandez BO, Feelisch M, Mietto C, Hod EA, Chipman D, Scherrer-Crosbie M, Bloch KD, Zapol WM. Autologous transfusion of stored red blood cells increases pulmonary artery pressure. Am J Respir Crit Care Med. 2014 Oct 01; 190(7):800-7. PMID: 25162920; PMCID: PMC4299609.
    Citations: 16     Fields:    Translation:Humans
  32. Rossaint R, Lewandowski K, Zapol WM. Our paper 20 years later: Inhaled nitric oxide for the acute respiratory distress syndrome--discovery, current understanding, and focussed targets of future applications. Intensive Care Med. 2014 Nov; 40(11):1649-58. PMID: 25201565.
    Citations: 3     Fields:    Translation:Humans
  33. Nakagawa A, Lui FE, Wassaf D, Yefidoff-Freedman R, Casalena D, Palmer MA, Meadows J, Mozzarelli A, Ronda L, Abdulmalik O, Bloch KD, Safo MK, Zapol WM. Identification of a small molecule that increases hemoglobin oxygen affinity and reduces SS erythrocyte sickling. ACS Chem Biol. 2014 Oct 17; 9(10):2318-25. PMID: 25061917; PMCID: PMC4205001.
    Citations: 11     Fields:    Translation:HumansCells
  34. Zhou GL, Beloiartsev A, Yu B, Baron DM, Zhou W, Niedra R, Lu N, Tainsh LT, Zapol WM, Seed B, Bloch KD. Deletion of the murine cytochrome P450 Cyp2j locus by fused BAC-mediated recombination identifies a role for Cyp2j in the pulmonary vascular response to hypoxia. PLoS Genet. 2013 Nov; 9(11):e1003950. PMID: 24278032; PMCID: PMC3836722.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  35. Baron DM, Beloiartsev A, Nakagawa A, Martyn T, Stowell CP, Malhotra R, Mayeur C, Bloch KD, Zapol WM. Adverse effects of hemorrhagic shock resuscitation with stored blood are ameliorated by inhaled nitric oxide in lambs*. Crit Care Med. 2013 Nov; 41(11):2492-501. PMID: 23887236; PMCID: PMC3812272.
    Citations: 10     Fields:    Translation:AnimalsCells
  36. Beloiartsev A, Baron DM, Yu B, Bloch KD, Zapol WM. Hemoglobin infusion does not alter murine pulmonary vascular tone. Nitric Oxide. 2013 Apr 01; 30:1-8. PMID: 23313572; PMCID: PMC3764648.
    Citations: 1     Fields:    Translation:Animals
  37. Lei C, Yu B, Shahid M, Beloiartsev A, Bloch KD, Zapol WM. Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock. Anesthesiology. 2012 Dec; 117(6):1190-202. PMID: 23168426; PMCID: PMC3852861.
    Citations: 16     Fields:    Translation:AnimalsCells
  38. Bergmark B, Bergmark R, Beaudrap PD, Boum Y, Mwanga-Amumpaire J, Carroll R, Zapol W. Inhaled nitric oxide and cerebral malaria: basis of a strategy for buying time for pharmacotherapy. Pediatr Infect Dis J. 2012 Dec; 31(12):e250-4. PMID: 22760538.
    Citations: 5     Fields:    Translation:Humans
  39. Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM. Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology. 2012 Jul; 117(1):56-63. PMID: 22531338; PMCID: PMC3980575.
    Citations: 15     Fields:    Translation:Humans
  40. Vaporidi K, Vergadi E, Kaniaris E, Hatziapostolou M, Lagoudaki E, Georgopoulos D, Zapol WM, Bloch KD, Iliopoulos D. Pulmonary microRNA profiling in a mouse model of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 01; 303(3):L199-207. PMID: 22659882; PMCID: PMC3423863.
    Citations: 24     Fields:    Translation:AnimalsCells
  41. Baron DM, Yu B, Lei C, Bagchi A, Beloiartsev A, Stowell CP, Steinbicker AU, Malhotra R, Bloch KD, Zapol WM. Pulmonary hypertension in lambs transfused with stored blood is prevented by breathing nitric oxide. Anesthesiology. 2012 Mar; 116(3):637-47. PMID: 22293717; PMCID: PMC3293704.
    Citations: 22     Fields:    Translation:Animals
  42. Yu B, Lei C, Baron DM, Steinbicker AU, Bloch KD, Zapol WM. Diabetes augments and inhaled nitric oxide prevents the adverse hemodynamic effects of transfusing syngeneic stored blood in mice. Transfusion. 2012 Jul; 52(7):1410-22. PMID: 22233290; PMCID: PMC3794463.
    Citations: 24     Fields:    Translation:AnimalsCells
  43. Derwall M, Malhotra R, Lai CS, Beppu Y, Aikawa E, Seehra JS, Zapol WM, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol. 2012 Mar; 32(3):613-22. PMID: 22223731; PMCID: PMC3679546.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  44. Serghides L, Kim H, Lu Z, Kain DC, Miller C, Francis RC, Liles WC, Zapol WM, Kain KC. Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One. 2011; 6(11):e27714. PMID: 22110737; PMCID: PMC3218025.
    Citations: 29     Fields:    Translation:AnimalsCells
  45. Lui FE, Yu B, Baron DM, Lei C, Zapol WM, Kluger R. Hemodynamic responses to a hemoglobin bis-tetramer and its polyethylene glycol conjugate. Transfusion. 2012 May; 52(5):974-82. PMID: 22070638.
    Citations: 1     Fields:    Translation:Animals
  46. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM. Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov; 115(5):1012-21. PMID: 21912243; PMCID: PMC3752661.
    Citations: 24     Fields:    Translation:Animals
  47. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11. PMID: 21934409; PMCID: PMC3194098.
    Citations: 2     Fields:    Translation:AnimalsCells
  48. Jiang Y, Bao FP, Liang Y, Kimball WR, Liu Y, Zapol WM, Kacmarek RM. Effectiveness of breathing through nasal and oral routes in unconscious apneic adult human subjects: a prospective randomized crossover trial. Anesthesiology. 2011 Jul; 115(1):129-35. PMID: 21572315.
    Citations: 4     Fields:    Translation:Humans
  49. Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011 Oct 30; 25(3):294-302. PMID: 21642009; PMCID: PMC3466086.
    Citations: 5     Fields:    Translation:AnimalsCells
  50. Zapol WM. Life at the frontier: the third annual John W. Severinghaus lecture on translational science. Anesthesiology. 2011 Apr; 114(4):771-81. PMID: 21358318.
    Citations: 1     Fields:    Translation:HumansAnimals
  51. Derwall M, Francis RC, Kida K, Bougaki M, Crimi E, Adrie C, Zapol WM, Ichinose F. Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects. Crit Care. 2011; 15(1):R51. PMID: 21299857; PMCID: PMC3221981.
    Citations: 11     Fields:    Translation:Animals
  52. Nagasaka Y, Buys ES, Spagnolli E, Steinbicker AU, Hayton SR, Rauwerdink KM, Brouckaert P, Zapol WM, Bloch KD. Soluble guanylate cyclase-a1 is required for the cardioprotective effects of inhaled nitric oxide. Am J Physiol Heart Circ Physiol. 2011 Apr; 300(4):H1477-83. PMID: 21257915; PMCID: PMC3075043.
    Citations: 9     Fields:    Translation:Animals
  53. Shahid M, Shen L, Seldin DC, Lu B, Ustyugova IV, Chen X, Zapol WM, Wu MX. Impaired 3',5'-cyclic adenosine monophosphate-mediated signaling in immediate early responsive gene X-1-deficient vascular smooth muscle cells. Hypertension. 2010 Oct; 56(4):705-12. PMID: 20713914; PMCID: PMC3157252.
    Citations: 6     Fields:    Translation:AnimalsCells
  54. Vaporidi K, Francis RC, Bloch KD, Zapol WM. Nitric oxide synthase 3 contributes to ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2010 Aug; 299(2):L150-9. PMID: 20453164; PMCID: PMC2928605.
    Citations: 16     Fields:    Translation:Animals
  55. Yu B, Shahid M, Egorina EM, Sovershaev MA, Raher MJ, Lei C, Wu MX, Bloch KD, Zapol WM. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier. Anesthesiology. 2010 Mar; 112(3):586-94. PMID: 20179495; PMCID: PMC2829726.
    Citations: 23     Fields:    Translation:Animals
  56. Yu B, Bloch KD, Zapol WM. Hemoglobin-based red blood cell substitutes and nitric oxide. Trends Cardiovasc Med. 2009 Apr; 19(3):103-7. PMID: 19679268; PMCID: PMC2756450.
    Citations: 9     Fields:    Translation:HumansAnimals
  57. Yu B, Volpato GP, Chang K, Bloch KD, Zapol WM. Prevention of the pulmonary vasoconstrictor effects of HBOC-201 in awake lambs by continuously breathing nitric oxide. Anesthesiology. 2009 Jan; 110(1):113-22. PMID: 19104178; PMCID: PMC2704389.
    Citations: 11     Fields:    Translation:Animals
  58. Nagasaka Y, Fernandez BO, Garcia-Saura MF, Petersen B, Ichinose F, Bloch KD, Feelisch M, Zapol WM. Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology. 2008 Oct; 109(4):675-82. PMID: 18813047; PMCID: PMC2632955.
    Citations: 31     Fields:    Translation:AnimalsCells
  59. Kitch BT, Cooper JB, Zapol WM, Marder JE, Karson A, Hutter M, Campbell EG. Handoffs causing patient harm: a survey of medical and surgical house staff. Jt Comm J Qual Patient Saf. 2008 Oct; 34(10):563-70. PMID: 18947116.
    Citations: 31     Fields:    Translation:Humans
  60. Fitzsimons MG, Baker KH, Lowenstein E, Zapol WM. Random drug testing to reduce the incidence of addiction in anesthesia residents: preliminary results from one program. Anesth Analg. 2008 Aug; 107(2):630-5. PMID: 18633044.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  61. Liang Y, Kimball WR, Kacmarek RM, Zapol WM, Jiang Y. Nasal ventilation is more effective than combined oral-nasal ventilation during induction of general anesthesia in adult subjects. Anesthesiology. 2008 Jun; 108(6):998-1003. PMID: 18497599.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  62. Falke KJ, Busch T, Hoffmann O, Liggins GC, Liggins J, Mohnhaupt R, Roberts JD, Stanek K, Zapol WM. Breathing pattern, CO2 elimination and the absence of exhaled NO in freely diving Weddell seals. Respir Physiol Neurobiol. 2008 Jun 30; 162(1):85-92. PMID: 18534926.
    Citations: 3     Fields:    Translation:Animals
  63. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90. PMID: 18391111; PMCID: PMC2733227.
    Citations: 42     Fields:    Translation:Animals
  64. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68. PMID: 18362598; PMCID: PMC2838418.
    Citations: 34     Fields:    Translation:Animals
  65. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8. PMID: 18055842.
    Citations: 8     Fields:    Translation:AnimalsCells
  66. Evgenov OV, Kohane DS, Bloch KD, Stasch JP, Volpato GP, Bellas E, Evgenov NV, Buys ES, Gnoth MJ, Graveline AR, Liu R, Hess DR, Langer R, Zapol WM. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1138-45. PMID: 17872487; PMCID: PMC2176100.
    Citations: 17     Fields:    Translation:Animals
  67. Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM. Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1300-5. PMID: 17720871.
    Citations: 2     Fields:    Translation:Animals
  68. Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH, Scherrer-Crosbie M. In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation. 2007 Sep 11; 116(11):1250-7. PMID: 17709634.
    Citations: 19     Fields:    Translation:Animals
  69. Bloch KD, Ichinose F, Roberts JD, Zapol WM. Inhaled NO as a therapeutic agent. Cardiovasc Res. 2007 Jul 15; 75(2):339-48. PMID: 17544387; PMCID: PMC1986790.
    Citations: 35     Fields:    Translation:HumansAnimals
  70. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H620-7. PMID: 17416602.
    Citations: 32     Fields:    Translation:AnimalsCells
  71. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    Citations: 2     Fields:    Translation:Humans
  72. Zapol W. A vision for International Polar year 2007-2008. Alaska Med. 2007; 49(2 Suppl):8-10. PMID: 17929598.
    Citations:    Fields:    Translation:Humans
  73. Jiang Y, Wain JC, Chang AW, Zapol WM, Xie Z. Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery. Anesth Analg. 2006 Aug; 103(2):312-5, table of contents. PMID: 16861410.
    Citations: 2     Fields:    Translation:Humans
  74. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84. PMID: 16443673.
    Citations: 46     Fields:    Translation:Animals
  75. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Inhaled nitric oxide does not reduce systemic vascular resistance in mice. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1826-9. PMID: 16299267.
    Citations: 5     Fields:    Translation:Animals
  76. Evgenov OV, Busch CJ, Evgenov NV, Liu R, Petersen B, Falkowski GE, Petho B, Vas A, Bloch KD, Zapol WM, Ichinose F. Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L723-L729. PMID: 16284211.
    Citations: 10     Fields:    Translation:Animals
  77. Falkowski PG, Katz ME, Milligan AJ, Fennel K, Cramer BS, Aubry MP, Berner RA, Novacek MJ, Zapol WM. The rise of oxygen over the past 205 million years and the evolution of large placental mammals. Science. 2005 Sep 30; 309(5744):2202-4. PMID: 16195457.
    Citations: 40     Fields:    Translation:AnimalsCells
  78. Lepore JJ, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients. J Heart Lung Transplant. 2005 Nov; 24(11):1950-6. PMID: 16297803.
    Citations: 5     Fields:    Translation:Humans
  79. Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):334-43. PMID: 15894604; PMCID: PMC2718472.
    Citations: 17     Fields:    Translation:Animals
  80. Lepore JJ, Maroo A, Bigatello LM, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of sildenafil in patients with congestive heart failure and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005 May; 127(5):1647-53. PMID: 15888841.
    Citations: 40     Fields:    Translation:Humans
  81. Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 2004 Oct 12; 110(15):2253-9. PMID: 15466650.
    Citations: 24     Fields:    Translation:Animals
  82. Zapol WM. Clifford J. Woolf, M.B., B,Ch., Ph.D. Recipient of the 2004 Excellence in Research Award. Anesthesiology. 2004 Oct; 101(4):820-3. PMID: 15461984.
    Citations:    Fields:    Translation:Humans
  83. Inglessis I, Shin JT, Lepore JJ, Palacios IF, Zapol WM, Bloch KD, Semigran MJ. Hemodynamic effects of inhaled nitric oxide in right ventricular myocardial infarction and cardiogenic shock. J Am Coll Cardiol. 2004 Aug 18; 44(4):793-8. PMID: 15312861.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  84. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7. PMID: 15286002.
    Citations: 59     Fields:    Translation:Animals
  85. Ichinose F, Roberts JD, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29; 109(25):3106-11. PMID: 15226227.
    Citations: 42     Fields:    Translation:Humans
  86. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2524-30. PMID: 12907425.
    Citations: 17     Fields:    Translation:AnimalsCells
  87. Baboolal HA, Ichinose F, Ullrich R, Kawai N, Bloch KD, Zapol WM. Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice. Anesthesiology. 2002 Nov; 97(5):1227-33. PMID: 12411809.
    Citations: 9     Fields:    Translation:Animals
  88. Hataishi R, Kobayashi H, Takahashi Y, Hirano S, Zapol WM, Jones RC. Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats. Anesthesiology. 2002 Oct; 97(4):887-95. PMID: 12357155.
    Citations: 3     Fields:    Translation:AnimalsCells
  89. Lepore JJ, Maroo A, Pereira NL, Ginns LC, Dec GW, Zapol WM, Bloch KD, Semigran MJ. Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults