Harvard Catalyst Profiles

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Warren Myron Zapol, M.D.

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Mentoring
Available: 12/10/20, Expires: 12/01/21

Can this translational novel device purify CO from blood in an ambulance for firemen/women or soldiers with Acute lung disease Student would join our team building and testing in CO poisoned pigs at MGH lab. No prior experience needed. Joint MGH DACC and Wellman lab project. Mentors Warren Zapol MD and R.Rox Anderson MD.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL042397 (ZAPOL, WARREN MYRON) Jul 1, 1990 - Jul 31, 2009
    NIH
    Inhaled nitric oxide
    Role: Principal Investigator
  2. P50HL023591 (ZAPOL, WARREN MYRON) Sep 30, 1978 - May 31, 1989
    NIH
    SCOR: ADULT RESPIRATORY FAILURE
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gianni S, Di Fenza R, Araujo Morais CC, Fakhr BS, Mueller AL, Yu B, Carroll RW, Ichinose F, Zapol WM, Berra L. A comparison between high dose nitric oxide delivered from pressurized cylinders and nitric oxide produced by an electric generator from air. A safety pilot study. Respir Care. 2021 Aug 19. PMID: 34413210.
    Citations:    Fields:    
  2. Safaee Fakhr B, Di Fenza R, Gianni S, Wiegand SB, Miyazaki Y, Araujo Morais CC, Gibson LE, Chang MG, Mueller AL, Rodriguez-Lopez JM, Ackman JB, Arora P, Scott LK, Bloch DB, Zapol WM, Carroll RW, Ichinose F, Berra L. Inhaled high dose nitric oxide is a safe and effective respiratory treatment in spontaneous breathing hospitalized patients with COVID-19 pneumonia. Nitric Oxide. 2021 11 01; 116:7-13. PMID: 34400339.
    Citations:    Fields:    Translation:Humans
  3. Fischbach A, Wiegand SB, Zazzeron L, Traeger L, di Fenza R, Bagchi A, Farinelli WA, Franco W, Korupolu S, Arens J, Grassi L, Zadek F, Bloch DB, Rox Anderson R, Zapol WM. Veno-venous extracorporeal blood phototherapy increases the rate of carbon monoxide (CO) elimination in CO-poisoned pigs. Lasers Surg Med. 2021 Aug 05. PMID: 34350599.
    Citations:    Fields:    
  4. Traeger L, Wiegand SB, Sauer AJ, Corman BHP, Peneyra KM, Wunderer F, Fischbach A, Bagchi A, Malhotra R, Zapol WM, Bloch DB. UBA6 and NDFIP1 regulate the degradation of ferroportin. Haematologica. 2021 Jul 29. PMID: 34320783.
    Citations:    Fields:    
  5. Pinciroli R, Traeger L, Fischbach A, Gianni S, Morais CCA, Fakhr BS, Di Fenza R, Robinson D, Carroll R, Zapol WM, Berra L. A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects. J Vis Exp. 2021 05 04; (171). PMID: 34028428.
    Citations:    Fields:    Translation:Humans
  6. Grange RMH, Sharma R, Shah H, Reinstadler B, Goldberger O, Cooper MK, Nakagawa A, Miyazaki Y, Hindle AG, Batten AJ, Wojtkiewicz GR, Schleifer G, Bagchi A, Marutani E, Malhotra R, Bloch DB, Ichinose F, Mootha VK, Zapol WM. Hypoxia ameliorates brain hyperoxia and NAD+ deficiency in a murine model of Leigh syndrome. Mol Genet Metab. 2021 05; 133(1):83-93. PMID: 33752971.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J. Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. Science. 2021 01 01; 371(6524):52-57. PMID: 33384370.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Wiegand SB, Traeger L, Nguyen HK, Rouillard KR, Fischbach A, Zadek F, Ichinose F, Schoenfisch MH, Carroll RW, Bloch DB, Zapol WM. Antimicrobial effects of nitric oxide in murine models of Klebsiella pneumonia. Redox Biol. 2021 02; 39:101826. PMID: 33352464.
    Citations:    Fields:    Translation:AnimalsCells
  9. Safaee Fakhr B, Wiegand SB, Pinciroli R, Gianni S, Morais CCA, Ikeda T, Miyazaki Y, Marutani E, Di Fenza R, Larson GM, Parcha V, Gibson LE, Chang MG, Arora P, Carroll RW, Kacmarek RM, Ichinose F, Barth WH, Kaimal A, Hohmann EL, Zapol WM, Berra L. High Concentrations of Nitric Oxide Inhalation Therapy in Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19). Obstet Gynecol. 2020 12; 136(6):1109-1113. PMID: 32852324.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  10. Wiegand SB, Safaee Fakhr B, Carroll RW, Zapol WM, Kacmarek RM, Berra L. Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019. Crit Care Explor. 2020 Nov; 2(11):e0277. PMID: 33225304.
    Citations: 1     
  11. Gianni S, Morais CCA, Larson G, Pinciroli R, Carroll R, Yu B, Zapol WM, Berra L. Ideation and assessment of a nitric oxide delivery system for spontaneously breathing subjects. Nitric Oxide. 2020 11 01; 104-105:29-35. PMID: 32835810.
    Citations: 2     Fields:    Translation:Humans
  12. Yu B, Zadek F, Fischbach A, Wiegand SB, Berra L, Bloch DB, Zapol WM. Intratracheal injection of nitric oxide, generated from air by pulsed electrical discharge, for the treatment of pulmonary hypertension in awake ambulatory lambs. Nitric Oxide. 2020 04 01; 97:11-15. PMID: 31982629.
    Citations: 1     Fields:    Translation:Animals
  13. Patgiri A, Skinner OS, Miyazaki Y, Schleifer G, Marutani E, Shah H, Sharma R, Goodman RP, To TL, Robert Bao X, Ichinose F, Zapol WM, Mootha VK. An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance. Nat Biotechnol. 2020 03; 38(3):309-313. PMID: 31932725.
    Citations: 17     Fields:    Translation:HumansCells
  14. Malhotra R, Mauer AC, Lino Cardenas CL, Guo X, Yao J, Zhang X, Wunderer F, Smith AV, Wong Q, Pechlivanis S, Hwang SJ, Wang J, Lu L, Nicholson CJ, Shelton G, Buswell MD, Barnes HJ, Sigurslid HH, Slocum C, Rourke CO, Rhee DK, Bagchi A, Nigwekar SU, Buys ES, Campbell CY, Harris T, Budoff M, Criqui MH, Rotter JI, Johnson AD, Song C, Franceschini N, Debette S, Hoffmann U, Kälsch H, Nöthen MM, Sigurdsson S, Freedman BI, Bowden DW, Jöckel KH, Moebus S, Erbel R, Feitosa MF, Gudnason V, Thanassoulis G, Zapol WM, Lindsay ME, Bloch DB, Post WS, O'Donnell CJ. HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype. Nat Genet. 2019 11; 51(11):1580-1587. PMID: 31659325.
    Citations: 11     Fields:    Translation:HumansAnimals
  15. Zazzeron L, Fischbach A, Franco W, Farinelli WA, Ichinose F, Bloch DB, Anderson RR, Zapol WM. Phototherapy and extracorporeal membrane oxygenation facilitate removal of carbon monoxide in rats. Sci Transl Med. 2019 10 09; 11(513). PMID: 31597752.
    Citations:    Fields:    Translation:Animals
  16. Lama TT, Berra L, Zapol WM. The Role of Nitric Oxide in Preventing Cardiopulmonary Bypass-associated Acute Kidney Injury. J Cardiothorac Vasc Anesth. 2020 03; 34(3):850-851. PMID: 31606280.
    Citations:    Fields:    Translation:Humans
  17. Yu B, Zapol WM, Berra L. Electrically generated nitric oxide from air: a safe and economical treatment for pulmonary hypertension. Intensive Care Med. 2019 11; 45(11):1612-1614. PMID: 31451859.
    Citations:    Fields:    Translation:Humans
  18. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3. PMID: 31402314.
    Citations: 19     Fields:    Translation:Animals
  19. Marrazzo F, Spina S, Zadek F, Lama T, Xu C, Larson G, Rezoagli E, Malhotra R, Zheng H, Bittner EA, Shelton K, Melnitchouk S, Roy N, Sundt TM, Riley WD, Williams P, Fisher D, Kacmarek RM, Thompson TB, Bonventre J, Zapol W, Ichinose F, Berra L. Protocol of a randomised controlled trial in cardiac surgical patients with endothelial dysfunction aimed to prevent postoperative acute kidney injury by administering nitric oxide gas. BMJ Open. 2019 07 04; 9(7):e026848. PMID: 31278097.
    Citations: 3     Fields:    Translation:Humans
  20. Lei C, Berra L, Xiong L, Zapol WM. Reply to Coutrot et al.: Is Nitric Oxide Nephro- or Cardioprotective? Am J Respir Crit Care Med. 2019 06 01; 199(11):1442-1443. PMID: 30840828.
    Citations: 1     Fields:    Translation:Humans
  21. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019 05 30; 177(6):1507-1521.e16. PMID: 31031004.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  22. Hindle AG, Allen KN, Batten AJ, Hückstädt LA, Turner-Maier J, Schulberg SA, Johnson J, Karlsson E, Lindblad-Toh K, Costa DP, Bloch DB, Zapol WM, Buys ES. Low guanylyl cyclase activity in Weddell seals: implications for peripheral vasoconstriction and perfusion of the brain during diving. . 2019 06 01; 316(6):R704-R715. PMID: 30892912.
    Citations: 6     Translation:AnimalsCells
  23. Zapol WM. Nitric Oxide Story. Anesthesiology. 2019 03; 130(3):435-440. PMID: 30664059.
    Citations: 1     Fields:    Translation:HumansAnimals
  24. Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome. . 2019 02 01; 316(2):L391-L399. PMID: 30520688.
    Citations: 1     Translation:AnimalsCells
  25. Yu B, Ichinose F, Bloch DB, Zapol WM. Inhaled nitric oxide. Br J Pharmacol. 2019 01; 176(2):246-255. PMID: 30288739.
    Citations: 8     Fields:    Translation:HumansAnimals
  26. Wang A, Singh S, Yu B, Bloch DB, Zapol WM, Kluger R. Cross-linked hemoglobin bis-tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation. Transfusion. 2019 01; 59(1):359-370. PMID: 30444016.
    Citations:    Fields:    Translation:HumansAnimals
  27. Lei C, Berra L, Rezoagli E, Yu B, Dong H, Yu S, Hou L, Chen M, Chen W, Wang H, Zheng Q, Shen J, Jin Z, Chen T, Zhao R, Christie E, Sabbisetti VS, Nordio F, Bonventre JV, Xiong L, Zapol WM. Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery. Am J Respir Crit Care Med. 2018 11 15; 198(10):1279-1287. PMID: 29932345.
    Citations: 20     Fields:    Translation:Humans
  28. Fitzsimons MG, Baker K, Malhotra R, Gottlieb A, Lowenstein E, Zapol WM. Reducing the Incidence of Substance Use Disorders in Anesthesiology Residents: 13 Years of Comprehensive Urine Drug Screening. Anesthesiology. 2018 10; 129(4):821-828. PMID: 30020101.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  29. Nagasaka Y, Fernandez BO, Steinbicker AU, Spagnolli E, Malhotra R, Bloch DB, Bloch KD, Zapol WM, Feelisch M. Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites. Nitric Oxide. 2018 11 01; 80:52-60. PMID: 30114529.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Goldstein SR, Liu C, Safo MK, Nakagawa A, Zapol WM, Winkler JD. Design, Synthesis, and Biological Evaluation of Allosteric Effectors That Enhance CO Release from Carboxyhemoglobin. ACS Med Chem Lett. 2018 Jul 12; 9(7):714-718. PMID: 30034606.
    Citations: 1     
  31. Nakagawa A, Ferrari M, Schleifer G, Cooper MK, Liu C, Yu B, Berra L, Klings ES, Safo RS, Chen Q, Musayev FN, Safo MK, Abdulmalik O, Bloch DB, Zapol WM. A Triazole Disulfide Compound Increases the Affinity of Hemoglobin for Oxygen and Reduces the Sickling of Human Sickle Cells. Mol Pharm. 2018 05 07; 15(5):1954-1963. PMID: 29634905.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  32. Yu B, Ferrari M, Schleifer G, Blaesi AH, Wepler M, Zapol WM, Bloch DB. Development of a portable mini-generator to safely produce nitric oxide for the treatment of infants with pulmonary hypertension. Nitric Oxide. 2018 05 01; 75:70-76. PMID: 29486304.
    Citations: 2     Fields:    Translation:Animals
  33. Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I. Pulmonary Delivery of Therapeutic and Diagnostic Gases. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):78-87. PMID: 29451844.
    Citations: 1     Fields:    Translation:Humans
  34. Kassa T, Strader MB, Nakagawa A, Zapol WM, Alayash AI. Targeting ßCys93 in hemoglobin S with an antisickling agent possessing dual allosteric and antioxidant effects. Metallomics. 2017 09 20; 9(9):1260-1270. PMID: 28770911.
    Citations: 7     Fields:    Translation:HumansCells
  35. Ichinose F, Zapol WM. Inhaled Pulmonary Vasodilators in Cardiac Surgery Patients: Correct Answer Is "NO". Anesth Analg. 2017 08; 125(2):375-377. PMID: 28731972.
    Citations: 1     Fields:    Translation:Humans
  36. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. BMC Anesthesiol. 2017 06 14; 17(1):76. PMID: 28615047.
    Citations: 2     Fields:    Translation:Animals
  37. Zazzeron L, Liu C, Franco W, Nakagawa A, Farinelli WA, Bloch DB, Anderson RR, Zapol WM. Pulmonary Phototherapy to Treat Carbon Monoxide Poisoning in Rats. Shock. 2017 06; 47(6):735-742. PMID: 27861257.
    Citations: 2     Fields:    Translation:Animals
  38. Ferrari M, Jain IH, Goldberger O, Rezoagli E, Thoonen R, Cheng KH, Sosnovik DE, Scherrer-Crosbie M, Mootha VK, Zapol WM. Hypoxia treatment reverses neurodegenerative disease in a mouse model of Leigh syndrome. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):E4241-E4250. PMID: 28483998.
    Citations: 41     Fields:    Translation:AnimalsCells
  39. Graw JA, Yu B, Rezoagli E, Warren HS, Buys ES, Bloch DB, Zapol WM. Endothelial dysfunction inhibits the ability of haptoglobin to prevent hemoglobin-induced hypertension. . 2017 Jun 01; 312(6):H1120-H1127. PMID: 28314763.
    Citations: 5     Translation:Animals
  40. Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. . 2016 Dec 01; 311(6):L1213-L1221. PMID: 27815261.
    Citations: 7     Translation:Animals
  41. Berra L, Rodriguez-Lopez J, Rezoagli E, Yu B, Fisher DF, Semigran MJ, Bloch DB, Channick RN, Zapol WM. Electric Plasma-generated Nitric Oxide: Hemodynamic Effects in Patients with Pulmonary Hypertension. Am J Respir Crit Care Med. 2016 11 01; 194(9):1168-1170. PMID: 27797618.
    Citations: