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Yasmin Mashhoon, Ph.D.

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2012 - 2017
NIDA K01 Early Onset Cigarette Smoking Effects on Brain Structure, Function and Chemistry
2012 - 2014
Early Onset Cigarette Smoking Effects on Brain Chemistry and Response Inhibition

I currently apply multi-modal neuroimaging approaches to study the effects of early onset cigarette smoking on electrophysiology, structural morphology and neurochemistry, and the relationship of potential alterations to cognitive deficits in nicotine-dependent adults. Empirical evidence from these studies may be used to predict if treatment approaches could be differentially implemented in early vs late onset smokers in order to improve smoking cessation outcomes.

My multidisciplinary approach to studying human behavior and alterations to brain architecture using advanced imaging techniques has resulted in numerous collaborations focused on cortical thickness in emerging adult binge drinkers and marijuana users, zolpidem-induced changes in healthy volunteers, changes in neurometabolite levels in smokers and marijuana users, altered hippocampal and thalamic volume in marijuana users, EEG measures of cue reactivity, and emotional reactivity in schizophrenic patients.

Collectively, my research program aims to elucidate molecular, electrophysiological and structural alterations in neural circuitry related to chronic drug use that destabilize brain function and consequently interfere with cognitive efficiency.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01DA034028 (MASHHOON, YASMIN) Jul 1, 2012 - Jun 30, 2017
    Early Onset Cigarette smoking effects on brain structure, function and chemistry
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mashhoon Y, Betts J, Farmer SL, Lukas SE. Early onset cigarette smokers exhibit greater P300 reactivity to smoking-related stimuli and report greater craving. Brain Res. 2018 May 15; 1687:173-184. PMID: 29524436.
    View in: PubMed
  2. Mashhoon Y, Betts J, Farmer SL, Lukas SE. Early onset tobacco cigarette smokers exhibit deficits in response inhibition and sustained attention. Drug Alcohol Depend. 2018 03 01; 184:48-56. PMID: 29402679.
    View in: PubMed
  3. McHugh RK, Fulciniti F, Mashhoon Y, Weiss RD. Cue-induced craving to paraphernalia and drug images in opioid dependence. Am J Addict. 2016 Mar; 25(2):105-9. PMID: 26848719; PMCID: PMC4883011 [Available on 03/01/17].
  4. Wetherill RR, Hager N, Jagannathan K, Mashhoon Y, Pater H, Childress AR, Franklin TR. Early Versus Late Onset of Cannabis Use: Differences in Striatal Response to Cannabis Cues. Cannabis Cannabinoid Res. 2016; 1(1):229-233. PMID: 28331903.
    View in: PubMed
  5. Maher S, Mashhoon Y, Ekstrom T, Lukas S, Chen Y. Deficient cortical face-sensitive N170 responses and basic visual processing in schizophrenia. Schizophr Res. 2016 Jan; 170(1):87-94. PMID: 26690888; PMCID: PMC4707115 [Available on 01/01/17].
  6. Mashhoon Y, Sava S, Sneider JT, Nickerson LD, Silveri MM. Cortical thinness and volume differences associated with marijuana abuse in emerging adults. Drug Alcohol Depend. 2015 Oct 01; 155:275-83. PMID: 26249265; PMCID: PMC4581973 [Available on 10/01/16].
  7. Mashhoon Y, Czerkawski C, Crowley DJ, Cohen-Gilbert JE, Sneider JT, Silveri MM. Binge alcohol consumption in emerging adults: anterior cingulate cortical "thinness" is associated with alcohol use patterns. Alcohol Clin Exp Res. 2014 Jul; 38(7):1955-64. PMID: 24961871; PMCID: PMC4107054.
  8. Sneider JT, Mashhoon Y, Silveri MM. A Review of Magnetic Resonance Spectroscopy Studies in Marijuana using Adolescents and Adults. J Addict Res Ther. 2013 Apr 24; Suppl 4. PMID: 24587965.
    View in: PubMed
  9. Mashhoon Y, Jensen JE, Sneider JT, Yurgelun-Todd DA, Silveri MM. Lower Left Thalamic Myo-Inositol Levels Associated with Greater Cognitive Impulsivity in Marijuana-Dependent Young Men: Preliminary Spectroscopic Evidence at 4T. J Addict Res Ther. 2013 Mar 20; Suppl 4. PMID: 24558635.
    View in: PubMed
  10. Mashhoon Y, Janes AC, Jensen JE, Prescot AP, Pachas G, Renshaw PF, Fava M, Evins AE, Kaufman MJ. Anterior cingulate proton spectroscopy glutamate levels differ as a function of smoking cessation outcome. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15; 35(7):1709-13. PMID: 21616118; PMCID: PMC3303218.
  11. Licata SC, Mashhoon Y, Maclean RR, Lukas SE. Modest abuse-related subjective effects of zolpidem in drug-naive volunteers. Behav Pharmacol. 2011 Apr; 22(2):160-6. PMID: 21301324; PMCID: PMC3077937.
  12. Mashhoon Y, Wells AM, Kantak KM. Interaction of the rostral basolateral amygdala and prelimbic prefrontal cortex in regulating reinstatement of cocaine-seeking behavior. Pharmacol Biochem Behav. 2010 Sep; 96(3):347-53. PMID: 20600250; PMCID: PMC2940107.
  13. Mashhoon Y, Tsikitas LA, Kantak KM. Dissociable effects of cocaine-seeking behavior following D1 receptor activation and blockade within the caudal and rostral basolateral amygdala in rats. Eur J Neurosci. 2009 Apr; 29(8):1641-53. PMID: 19419427; PMCID: PMC2905154.
  14. Kantak KM, Mashhoon Y, Silverman DN, Janes AC, Goodrich CM. Role of the orbitofrontal cortex and dorsal striatum in regulating the dose-related effects of self-administered cocaine. Behav Brain Res. 2009 Jul 19; 201(1):128-36. PMID: 19428626; PMCID: PMC2905169.
  15. Di Pietro NC, Mashhoon Y, Heaney C, Yager LM, Kantak KM. Role of dopamine D1 receptors in the prefrontal dorsal agranular insular cortex in mediating cocaine self-administration in rats. Psychopharmacology (Berl). 2008 Sep; 200(1):81-91. PMID: 18584153; PMCID: PMC2587221.
  16. Atkins AL, Mashhoon Y, Kantak KM. Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior. Pharmacol Biochem Behav. 2008 Sep; 90(3):481-91. PMID: 18499239; PMCID: PMC2562730.
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