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Rakesh Karmacharya, M.D.,Ph.D.

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Biography
Massachusetts Institute of Technology, Cambridge, MA06/1989Physical Sciences
Harvard University, Cambridge, MAA.B.06/1993Biochemical Sciences
Yale University, New Haven, CTM.S.06/1994Molecular Biophysics & Biochemistry
Albert Einstein College of Medicine, Bronx, NYM.D., Ph.D.06/2002Biophysics
Harvard Medical School, Boston, MAM.M.Sc.06/2009Translational Medicine
2004 - 2004
National Institute of Mental Health (NIMH) Outstanding Resident Award
2006 - 2007
Dorothy C. Kempf Award, American Psychiatric Association
2007 - 2009
Daland Fellow, American Philosophical Society
2007 - 2008
Young Minds in Psychiatry International Award, American Psychiatric Association
2009 - 2010
Maria Lorenz Pope Fellow, Harvard Medical School
2009 - 2009
Alfred Pope Award, McLean Hospital
2010 - 2011
NARSAD Young Investigator Award
2011 - 2013
Harvard Stem Cell Institute (HSCI) Seed Grant Award
2012 - 2012
MIT Koch Institute Image Award
2012 - 2012
NCDEU New Investigator Award
2013 - 2014
Rappaport Research Scholar in Neuroscience
2015 - 2019
Doris Duke Charitable Foundation Clinical Scientist Development Award
2017 - 2020
Robert Wood Johnson Foundation Clinical Scholar Award
2017 - 2022
NIMH BRAINS Award
2019 - 2021
HSCI Bowes Accelerator Seed Grant Award

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH113858 (KARMACHARYA, RAKESH) Jul 1, 2017 - Mar 31, 2022
    NIH/NIMH
    Ex vivo signature of psychosis and treatment response in patient-derived neurons
    Role: Principal Investigator
  2. K08MH086846 (KARMACHARYA, RAKESH) Jul 1, 2010 - Jun 30, 2015
    NIH/NIMH
    Wnt/GSK3/beta Catenin Signaling as a Target for Treatment of Bipolar Disorder
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kathuria A, Lopez-Lengowski K, Jagtap SS, McPhie D, Perlis RH, Cohen BM, Karmacharya R. Transcriptomic Landscape and Functional Characterization of Induced Pluripotent Stem Cell-Derived Cerebral Organoids in Schizophrenia. JAMA Psychiatry. 2020 Mar 18. PMID: 32186681.
    Citations:    
  2. Cawkwell PB, Bolton KW, Karmacharya R, Öngür D, Shinn AK. Two-year diagnostic stability in a real-world sample of individuals with early psychosis. Early Interv Psychiatry. 2020 Feb 10. PMID: 32043313.
    Citations:    
  3. Kathuria A, Lopez-Lengowski K, Watmuff B, McPhie D, Cohen BM, Karmacharya R. Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine. Transl Psychiatry. 2019 Nov 28; 9(1):321. PMID: 31780643.
    Citations:    
  4. Pedersen GA, Zajkowska Z, Kieling C, Gautam K, Mondelli V, Fisher HL, Swartz JR, Adewuya A, Karmacharya R, Kohrt BA. Protocol for a systematic review of the development of depression among adolescents and young adults: psychological, biological, and contextual perspectives around the world. Syst Rev. 2019 07 20; 8(1):179. PMID: 31325965.
    Citations:    
  5. Kieling C, Adewuya A, Fisher HL, Karmacharya R, Kohrt BA, Swartz JR, Mondelli V. Identifying depression early in adolescence. Lancet Child Adolesc Health. 2019 Apr; 3(4):211-213. PMID: 30878111.
    Citations:    
  6. Iaconelli J, Xuan L, Karmacharya R. HDAC6 Modulates Signaling Pathways Relevant to Synaptic Biology and Neuronal Differentiation in Human Stem-Cell-Derived Neurons. Int J Mol Sci. 2019 Mar 31; 20(7). PMID: 30935091.
    Citations:    
  7. Sellgren CM, Gracias J, Watmuff B, Biag JD, Thanos JM, Whittredge PB, Fu T, Worringer K, Brown HE, Wang J, Kaykas A, Karmacharya R, Goold CP, Sheridan SD, Perlis RH. Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning. Nat Neurosci. 2019 03; 22(3):374-385. PMID: 30718903.
    Citations:    
  8. Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R. Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. ACS Chem Biol. 2017 08 18; 12(8):2139-2148. PMID: 28628306.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  9. Watmuff B, Liu B, Karmacharya R. Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder. Pharmacogenomics. 2017 Apr; 18(5):471-479. PMID: 28346060.
    Citations:    Fields:    Translation:HumansCells
  10. Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017 02 03; 16(2):481-493. PMID: 28152600.
    Citations: 1     Fields:    Translation:HumansCells
  11. Huang JH, Berkovitch SS, Iaconelli J, Watmuff B, Park H, Chattopadhyay S, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates a-Aminoadipate as a Potential Biomarker for Bipolar Disorder. Mol Neuropsychiatry. 2016 Jul; 2(2):97-106. PMID: 27606323.
    Citations:    
  12. Wimalasena NK, Le VQ, Wimalasena K, Schreiber SL, Karmacharya R. Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. ACS Chem Neurosci. 2016 07 20; 7(7):857-63. PMID: 27270122.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Karmacharya R, Haggarty SJ. Stem cell models of neuropsychiatric disorders. Mol Cell Neurosci. 2016 06; 73:1-2. PMID: 27013423.
    Citations:    Fields:    Translation:HumansCells
  14. Watmuff B, Berkovitch SS, Huang JH, Iaconelli J, Toffel S, Karmacharya R. Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells. Mol Cell Neurosci. 2016 06; 73:96-103. PMID: 26777134.
    Citations: 3     Fields:    Translation:HumansCells
  15. Shinn AK, Bolton KW, Karmacharya R, Lewandowski KE, Yuksel C, Baker JT, Chouinard VA, Pingali SM, Bye H, Cederbaum K, Öngür D. McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis. Early Interv Psychiatry. 2017 02; 11(1):83-90. PMID: 26616380.
    Citations: 3     Fields:    Translation:Humans
  16. Kang SH, Han HR, Lee JI, Karmacharya R, Jeon HJ, Roh S. Effects of LEP, LEPR, ADIPOQ, MC4R and FTO polymorphisms on dyslipidemia in Korean patients with schizophrenia who are taking clozapine. Psychiatry Res. 2015 Jul 30; 228(1):177-8. PMID: 25841316.
    Citations: 1     Fields:    
  17. Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MAS, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 10; 10(5):755-770. PMID: 25660025.
    Citations: 6     Fields:    
  18. Iaconelli J, Huang JH, Berkovitch SS, Chattopadhyay S, Mazitschek R, Schreiber SL, Haggarty SJ, Karmacharya R. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ß-catenin in human iPSC-derived neuronal cells. ACS Chem Biol. 2015 Mar 20; 10(3):883-90. PMID: 25546293.
    Citations: 4     Fields:    Translation:HumansCells
  19. Berkovitch SS, Iaconelli J, Karmacharya R. Patient-derived iPSCs as a model for schizophrenia. Journal of Stem Cell Research & Regenerative Medicine. 2015; (2):e001.
  20. Haggarty SJ, Singh K, Perlis R, Karmacharya R. Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions (Ed: SP Hoppler, RT Moon). Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway. 2014; Chapter 31. View Publication.
  21. Haggarty SJ, Singh K, Perlis R, Karmacharya R. Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions (Ed: SP Hoppler, RT Moon). Wnt Signaling in Mood & Psychotic Disorders. 2014; Chapter 30. View Publication.
  22. Mehrmann C, Karmacharya R. Principles and neurobiological correlates of concentrative, diffuse, and insight meditation. Harv Rev Psychiatry. 2013 Jul-Aug; 21(4):205-18. PMID: 24651509.
    Citations:    Fields:    Translation:Humans
  23. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. Brain Res. 2011 Jun 01; 1393:91-9. PMID: 21529784.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  24. England ML, Ongür D, Konopaske GT, Karmacharya R. Catatonia in psychotic patients: clinical features and treatment response. J Neuropsychiatry Clin Neurosci. 2011; 23(2):223-6. PMID: 21677256.
    Citations: 15     Fields:    Translation:Humans
  25. Biechele TL, Camp ND, Fass DM, Kulikauskas RM, Robin NC, White BD, Taraska CM, Moore EC, Muster J, Karmacharya R, Haggarty SJ, Chien AJ, Moon RT. Chemical-genetic screen identifies riluzole as an enhancer of Wnt/ß-catenin signaling in melanoma. Chem Biol. 2010 Nov 24; 17(11):1177-82. PMID: 21095567.
    Citations: 24     Fields:    Translation:AnimalsCells
  26. Karmacharya R, Sliwoski GR, Lundy MY, Suckow RF, Cohen BM, Buttner EA. Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans. Neuropsychopharmacology. 2009 Jul; 34(8):1968-78. PMID: 19322168.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Karmacharya R, England ML, Ongür D. Delirious mania: clinical features and treatment response. J Affect Disord. 2008 Aug; 109(3):312-6. PMID: 18191210.
    Citations: 11     Fields:    Translation:Humans
  28. Karmacharya R, Mino M, Pirl WF. Clozapine-induced eosinophilic colitis. Am J Psychiatry. 2005 Jul; 162(7):1386-7. PMID: 15994729.
    Citations: 9     Fields:    Translation:Humans
  29. Karmacharya R, Antoniou D, Schwartz SD. Nonequilibrium Solvation and Quantum Kramers Problem: Proton Transfer in Aqueous Glycine. Journal of Physical Chemistry A. 2001; 105(12):2563-7. View Publication.
  30. Karmacharya R, Gross P, Schwartz SD. The Effect of Coupled Nonreactive Modes on Laser Control of Quantum Wavepacket Dynamics. Journal of Chemical Physics. 1999; 111(15):6864-8. View Publication.
  31. Karmacharya R, Schwartz SD. Quantum Proton Transfer Coupled to a Quantum Anharmonic Mode. Journal of Chemical Physics. 1999; 110(15):7376-81. View Publication.
  32. Karmacharya R. Protein Modules in Intracellular Signaling Pathways. Einstein Quarterly Journal of Biology and Medicine. 1996; 2(13):62-71.
  33. Lee AY, Hagihara M, Karmacharya R, Albers MW, Schreiber SL, Clardy J. Atomic Structure of the Trypsin-Cyclotheonamide A Complex: Lessons for the Design of Serine Protease Inhibitors. Journal of the American Chemical Society. 1993; 115(26):12619-20. View Publication.
  34. Schreiber SL, Liu J, Albers MW, Karmacharya R, Koh E, Martin PK, Rosen MK, Standaert RF, Wandless TJ. Immunophilin-ligand complexes as probes of intracellular signaling pathways. Transplant Proc. 1991 Dec; 23(6):2839-44. PMID: 1721293.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.