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Last Name

profileRakesh Karmacharya, M.D.,Ph.D.

TitleAssistant Professor of Psychiatry
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Center for Genomic Medicine
185 Cambridge St
Boston MA 02114
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Collapse Biography 
Collapse education and training
Massachusetts Institute of Technology, Cambridge, MA06/1989Physical Sciences
Harvard University, Cambridge, MAA.B.06/1993Biochemical Sciences
Yale University, New Haven, CTM.S.06/1994Molecular Biophysics & Biochemistry
Albert Einstein College of Medicine, Bronx, NYM.D., Ph.D.06/2002Biophysics
Harvard Medical School, Boston, MAM.M.Sc.06/2009Translational Medicine
Collapse awards and honors
2004 - 2004National Institute of Mental Health (NIMH) Outstanding Resident Award
2006 - 2007Dorothy C. Kempf Award, American Psychiatric Association
2007 - 2009Daland Fellow, American Philosophical Society
2007 - 2008Young Minds in Psychiatry International Award, American Psychiatric Association
2009 - 2010Maria Lorenz Pope Fellow, Harvard Medical School
2009 - 2009Alfred Pope Award, McLean Hospital
2010 - 2011NARSAD Young Investigator Award
2011 - 2013Harvard Stem Cell Institute (HSCI) Seed Grant Award
2012 - 2012MIT Koch Institute Image Award
2012 - 2012NCDEU New Investigator Award
2013 - 2014Rappaport Research Scholar in Neuroscience
2015 - 2018Doris Duke Charitable Foundation Clinical Scientist Development Award
2017 - 2022NIMH Biobehavioral Research Awards for Innovative New Scientists
2017 - 2020Robert Wood Johnson Foundation Clinical Scholar Award

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01MH113858     (KARMACHARYA, RAKESH)Jul 1, 2017 - Mar 31, 2022
Ex vivo signature of psychosis and treatment response in patient-derived neurons
Role: Principal Investigator

K08MH086846     (KARMACHARYA, RAKESH)Jul 1, 2010 - Jun 30, 2015
Wnt/GSK3/beta Catenin Signaling as a Target for Treatment of Bipolar Disorder
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Iaconelli J, Lalonde J, Watmuff B, Liu B, Mazitschek R, Haggarty SJ, Karmacharya R. Lysine Deacetylation by HDAC6 Regulates the Kinase Activity of AKT in Human Neural Progenitor Cells. ACS Chem Biol. 2017 Aug 18; 12(8):2139-2148. PMID: 28628306.
    View in: PubMed
  2. Watmuff B, Liu B, Karmacharya R. Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder. Pharmacogenomics. 2017 Apr; 18(5):471-479. PMID: 28346060.
    View in: PubMed
  3. Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017 Feb 03; 16(2):481-493. PMID: 28152600.
    View in: PubMed
  4. Huang JH, Berkovitch SS, Iaconelli J, Watmuff B, Park H, Chattopadhyay S, McPhie D, Öngür D, Cohen BM, Clish CB, Karmacharya R. Perturbational Profiling of Metabolites in Patient Fibroblasts Implicates a-Aminoadipate as a Potential Biomarker for Bipolar Disorder. Mol Neuropsychiatry. 2016 Jul; 2(2):97-106. PMID: 27606323; PMCID: PMC4996006 [Available on 07/01/17].
  5. Wimalasena NK, Le VQ, Wimalasena K, Schreiber SL, Karmacharya R. Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent. ACS Chem Neurosci. 2016 Jul 20; 7(7):857-63. PMID: 27270122.
    View in: PubMed
  6. Karmacharya R, Haggarty SJ. Stem cell models of neuropsychiatric disorders. Mol Cell Neurosci. 2016 06; 73:1-2. PMID: 27013423.
    View in: PubMed
  7. Watmuff B, Berkovitch SS, Huang JH, Iaconelli J, Toffel S, Karmacharya R. Disease signatures for schizophrenia and bipolar disorder using patient-derived induced pluripotent stem cells. Mol Cell Neurosci. 2016 Jun; 73:96-103. PMID: 26777134; PMCID: PMC4867281 [Available on 06/01/17].
  8. Shinn AK, Bolton KW, Karmacharya R, Lewandowski KE, Yuksel C, Baker JT, Chouinard VA, Pingali SM, Bye H, Cederbaum K, Öngür D. McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis. Early Interv Psychiatry. 2017 02; 11(1):83-90. PMID: 26616380.
    View in: PubMed
  9. Kang SH, Han HR, Lee JI, Karmacharya R, Jeon HJ, Roh S. Effects of LEP, LEPR, ADIPOQ, MC4R and FTO polymorphisms on dyslipidemia in Korean patients with schizophrenia who are taking clozapine. Psychiatry Res. 2015 Jul 30; 228(1):177-8. PMID: 25841316.
    View in: PubMed
  10. Chattopadhyay S, Stewart AL, Mukherjee S, Huang C, Hartwell KA, Miller PG, Subramanian R, Carmody LC, Yusuf RZ, Sykes DB, Paulk J, Vetere A, Vallet S, Santo L, Cirstea DD, Hideshima T, Dancík V, Majireck MM, Hussain MM, Singh S, Quiroz R, Iaconelli J, Karmacharya R, Tolliday NJ, Clemons PA, Moore MA, Stern AM, Shamji AF, Ebert BL, Golub TR, Raje NS, Scadden DT, Schreiber SL. Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors. Cell Rep. 2015 Feb 04. PMID: 25660025.
    View in: PubMed
  11. Iaconelli J, Huang JH, Berkovitch SS, Chattopadhyay S, Mazitschek R, Schreiber SL, Haggarty SJ, Karmacharya R. HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of ß-catenin in human iPSC-derived neuronal cells. ACS Chem Biol. 2015 Mar 20; 10(3):883-90. PMID: 25546293; PMCID: PMC4372110.
  12. Berkovitch SS, Iaconelli J, Karmacharya R. Patient-derived iPSCs as a model for schizophrenia. Journal of Stem Cell Research & Regenerative Medicine. 2015; (2):e001.
  13. Haggarty SJ, Singh K, Perlis R, Karmacharya R. Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions (Ed: SP Hoppler, RT Moon). Neuropsychiatric Disease-Associated Genetic Variation in the Wnt Pathway. 2014; Chapter 31.
  14. Haggarty SJ, Singh K, Perlis R, Karmacharya R. Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions (Ed: SP Hoppler, RT Moon). Wnt Signaling in Mood & Psychotic Disorders. 2014; Chapter 30.
  15. Mehrmann C, Karmacharya R. Principles and neurobiological correlates of concentrative, diffuse, and insight meditation. Harv Rev Psychiatry. 2013 Jul-Aug; 21(4):205-18. PMID: 24651509.
    View in: PubMed
  16. Karmacharya R, Lynn SK, Demarco S, Ortiz A, Wang X, Lundy MY, Xie Z, Cohen BM, Miller GM, Buttner EA. Behavioral effects of clozapine: involvement of trace amine pathways in C. elegans and M. musculus. Brain Res. 2011 Jun 01; 1393:91-9. PMID: 21529784; PMCID: PMC3107707.
  17. England ML, Ongür D, Konopaske GT, Karmacharya R. Catatonia in psychotic patients: clinical features and treatment response. J Neuropsychiatry Clin Neurosci. 2011; 23(2):223-6. PMID: 21677256; PMCID: PMC3369314.
  18. Biechele TL, Camp ND, Fass DM, Kulikauskas RM, Robin NC, White BD, Taraska CM, Moore EC, Muster J, Karmacharya R, Haggarty SJ, Chien AJ, Moon RT. Chemical-genetic screen identifies riluzole as an enhancer of Wnt/ß-catenin signaling in melanoma. Chem Biol. 2010 Nov 24; 17(11):1177-82. PMID: 21095567; PMCID: PMC3044442.
  19. Karmacharya R, Sliwoski GR, Lundy MY, Suckow RF, Cohen BM, Buttner EA. Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans. Neuropsychopharmacology. 2009 Jul; 34(8):1968-78. PMID: 19322168; PMCID: PMC3348699.
  20. Karmacharya R, England ML, Ongür D. Delirious mania: clinical features and treatment response. J Affect Disord. 2008 Aug; 109(3):312-6. PMID: 18191210.
    View in: PubMed
  21. Karmacharya R, Mino M, Pirl WF. Clozapine-induced eosinophilic colitis. Am J Psychiatry. 2005 Jul; 162(7):1386-7. PMID: 15994729.
    View in: PubMed
  22. Karmacharya R, Antoniou D, Schwartz SD. Nonequilibrium Solvation and Quantum Kramers Problem: Proton Transfer in Aqueous Glycine. Journal of Physical Chemistry A. 2001; 105(12):2563-7.
  23. Karmacharya R, Gross P, Schwartz SD. The Effect of Coupled Nonreactive Modes on Laser Control of Quantum Wavepacket Dynamics. Journal of Chemical Physics. 1999; 111(15):6864-8.
  24. Karmacharya R, Schwartz SD. Quantum Proton Transfer Coupled to a Quantum Anharmonic Mode. Journal of Chemical Physics. 1999; 110(15):7376-81.
  25. Karmacharya R. Protein Modules in Intracellular Signaling Pathways. Einstein Quarterly Journal of Biology and Medicine. 1996; 2(13):62-71.
  26. Lee AY, Hagihara M, Karmacharya R, Albers MW, Schreiber SL, Clardy J. Atomic Structure of the Trypsin-Cyclotheonamide A Complex: Lessons for the Design of Serine Protease Inhibitors. Journal of the American Chemical Society. 1993; 115(26):12619-20.
  27. Schreiber SL, Liu J, Albers MW, Karmacharya R, Koh E, Martin PK, Rosen MK, Standaert RF, Wandless TJ. Immunophilin-ligand complexes as probes of intracellular signaling pathways. Transplant Proc. 1991 Dec; 23(6):2839-44. PMID: 1721293.
    View in: PubMed
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