Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Seth Leo Alper, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Seth Alper and Boris Shmukler.
Connection Strength

13.683
  1. Erythroid-specific inactivation of Slc12a6/Kcc3 by EpoR promoter-driven Cre expression reduces K-Cl cotransport activity in mouse erythrocytes. Physiol Rep. 2022 03; 10(5):e15186.
    View in: PubMed
    Score: 0.990
  2. Corrigendum to "Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease" [Blood Cells Mol. Dis. (2019) start page-end page not yet assigned] https://doi.org/10.1016/j.bcmd.2019.102346. Blood Cells Mol Dis. 2020 Mar; 81:102390.
    View in: PubMed
    Score: 0.853
  3. Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia. Blood Cells Mol Dis. 2020 03; 81:102389.
    View in: PubMed
    Score: 0.846
  4. Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2019 11; 79:102346.
    View in: PubMed
    Score: 0.825
  5. Authors' response to "Comment on: 'Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia'". Haematologica. 2016 Jan; 101(1):e39.
    View in: PubMed
    Score: 0.646
  6. Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia. Haematologica. 2015 Dec; 100(12):e483-5.
    View in: PubMed
    Score: 0.629
  7. Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Arch. 2014 Aug; 466(8):1605-18.
    View in: PubMed
    Score: 0.571
  8. Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.
    View in: PubMed
    Score: 0.548
  9. N-ethylmaleimide activates a Cl(-)-independent component of K(+) flux in mouse erythrocytes. Blood Cells Mol Dis. 2013 Jun; 51(1):9-16.
    View in: PubMed
    Score: 0.531
  10. Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout. Br J Haematol. 2013 May; 161(4):602-4.
    View in: PubMed
    Score: 0.529
  11. Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25.
    View in: PubMed
    Score: 0.496
  12. Hemolytic anemia and distal renal tubular acidosis in two Indian patients homozygous for SLC4A1/AE1 mutation A858D. Am J Hematol. 2010 Oct; 85(10):824-8.
    View in: PubMed
    Score: 0.449
  13. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol. 2008 Mar; 294(3):R1081-91.
    View in: PubMed
    Score: 0.368
  14. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.
    View in: PubMed
    Score: 0.309
  15. Trpv1 and Trpa1 are not essential for Psickle-like activity in red cells of the SAD mouse model of sickle cell disease. Blood Cells Mol Dis. 2021 12; 92:102619.
    View in: PubMed
    Score: 0.242
  16. A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. Haematologica. 2021 10 01; 106(10):2759-2762.
    View in: PubMed
    Score: 0.240
  17. Structure and complex transcription pattern of the mouse SK1 K(Ca) channel gene, KCNN1. Biochim Biophys Acta. 2001 Mar 19; 1518(1-2):36-46.
    View in: PubMed
    Score: 0.232
  18. Structure and genetic polymorphism of the mouse KCC1 gene. Biochim Biophys Acta. 2000 Jul 24; 1492(2-3):353-61.
    View in: PubMed
    Score: 0.221
  19. Short sequence repeat polymorphism in the mouse slc4al gene encoding the AE1 Cl-/HCO3-exchanger. DNA Seq. 2000; 11(5):447-50.
    View in: PubMed
    Score: 0.213
  20. Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells. Am J Physiol Cell Physiol. 2019 08 01; 317(2):C287-C302.
    View in: PubMed
    Score: 0.204
  21. Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M. Hemasphere. 2018 10; 2(5):e55.
    View in: PubMed
    Score: 0.195
  22. Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc. Am J Hematol. 2017 06; 92(6):E108-E110.
    View in: PubMed
    Score: 0.177
  23. Reinterpretation of the RACTK1 K+ channel. Am J Physiol. 1997 Jan; 272(1 Pt 1):C350-4.
    View in: PubMed
    Score: 0.173
  24. Loss of kAE1 expression in collecting ducts of end-stage kidneys from a family with SLC4A1 G609R-associated distal renal tubular acidosis. Clin Kidney J. 2017 Feb; 10(1):135-140.
    View in: PubMed
    Score: 0.169
  25. BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. Am J Physiol Cell Physiol. 2015 Sep 01; 309(5):C332-47.
    View in: PubMed
    Score: 0.156
  26. Congenital chloride-losing diarrhea in a Mexican child with the novel homozygous SLC26A3 mutation G393W. Front Physiol. 2015; 6:179.
    View in: PubMed
    Score: 0.156
  27. Substitution of transmembrane domain Cys residues alters pH(o)-sensitive anion transport by AE2/SLC4A2 anion exchanger. Pflugers Arch. 2013 Jun; 465(6):839-51.
    View in: PubMed
    Score: 0.131
  28. Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50.
    View in: PubMed
    Score: 0.121
  29. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43.
    View in: PubMed
    Score: 0.119
  30. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. Am J Physiol Cell Physiol. 2011 Aug; 301(2):C289-303.
    View in: PubMed
    Score: 0.117
  31. Interactions of mouse glycophorin A with the dRTA-related mutant G719D of the mouse Cl-/HCO3- exchanger Ae1. Biochem Cell Biol. 2011 Apr; 89(2):224-35.
    View in: PubMed
    Score: 0.116
  32. Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. Am J Physiol Cell Physiol. 2011 May; 300(5):C1034-46.
    View in: PubMed
    Score: 0.114
  33. Regulated transport of sulfate and oxalate by SLC26A2/DTDST. Am J Physiol Cell Physiol. 2010 Jun; 298(6):C1363-75.
    View in: PubMed
    Score: 0.108
  34. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732.
    View in: PubMed
    Score: 0.107
  35. Chemical crosslinking studies with the mouse Kcc1 K-Cl cotransporter. Blood Cells Mol Dis. 2009 May-Jun; 42(3):233-40.
    View in: PubMed
    Score: 0.102
  36. Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells. Am J Physiol Renal Physiol. 2009 Jun; 296(6):F1464-76.
    View in: PubMed
    Score: 0.100
  37. Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct. J Med Invest. 2009; 56 Suppl:329-31.
    View in: PubMed
    Score: 0.099
  38. Mouse strain-specific coding polymorphism in the Slc4a2/Ae2 gene encodes Ae2c2 variants differing in isoform-specific dominant negative activity. Exp Physiol. 2008 Apr; 93(4):458-67.
    View in: PubMed
    Score: 0.093
  39. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.
    View in: PubMed
    Score: 0.093
  40. Acute regulation of mouse AE2 anion exchanger requires isoform-specific amino acid residues from most of the transmembrane domain. J Physiol. 2007 Oct 01; 584(Pt 1):59-73.
    View in: PubMed
    Score: 0.090
  41. Alkaline-shifted pHo sensitivity of AE2c1-mediated anion exchange reveals novel regulatory determinants in the AE2 N-terminal cytoplasmic domain. J Biol Chem. 2006 Jan 27; 281(4):1885-96.
    View in: PubMed
    Score: 0.080
  42. Deficient HCO3- transport in an AE1 mutant with normal Cl- transport can be rescued by carbonic anhydrase II presented on an adjacent AE1 protomer. J Biol Chem. 2003 Nov 07; 278(45):44949-58.
    View in: PubMed
    Score: 0.068
  43. Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol. 2003 May 15; 549(Pt 1):3-19.
    View in: PubMed
    Score: 0.067
  44. Regulation of AE2-mediated Cl- transport by intracellular or by extracellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytoplasmic domain. J Gen Physiol. 2002 Nov; 120(5):707-22.
    View in: PubMed
    Score: 0.065
  45. Immunolocalization of potassium-chloride cotransporter polypeptides in rat exocrine glands. Histochem Cell Biol. 2002 Apr; 117(4):335-44.
    View in: PubMed
    Score: 0.062
  46. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 09; 276(45):41870-8.
    View in: PubMed
    Score: 0.060
  47. AE anion exchangers in atrial tumor cells. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H937-45.
    View in: PubMed
    Score: 0.058
  48. Mouse K-Cl cotransporter KCC1: cloning, mapping, pathological expression, and functional regulation. Am J Physiol. 1999 11; 277(5):C899-912.
    View in: PubMed
    Score: 0.053
  49. Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis. Kidney Int. 2020 03; 97(3):567-579.
    View in: PubMed
    Score: 0.053
  50. Expression of AE2 anion exchanger in mouse intestine. Am J Physiol. 1999 08; 277(2):G321-32.
    View in: PubMed
    Score: 0.052
  51. AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. Biochemistry. 1999 Jun 29; 38(26):8521-31.
    View in: PubMed
    Score: 0.051
  52. cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.
    View in: PubMed
    Score: 0.048
  53. Immunolocalization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. J Am Soc Nephrol. 1998 Jun; 9(6):946-59.
    View in: PubMed
    Score: 0.048
  54. Immunolocalization of AE2 anion exchanger in rat kidney. Am J Physiol. 1997 10; 273(4):F601-14.
    View in: PubMed
    Score: 0.046
  55. Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. Sci Rep. 2016 10 26; 6:35986.
    View in: PubMed
    Score: 0.043
  56. Atypical patterns of segregation of familial enlargement of the vestibular aqueduct. Laryngoscope. 2016 07; 126(7):E240-7.
    View in: PubMed
    Score: 0.040
  57. The Clinically Tested Gardos Channel Inhibitor Senicapoc Exhibits Antimalarial Activity. Antimicrob Agents Chemother. 2016 01; 60(1):613-6.
    View in: PubMed
    Score: 0.040
  58. Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (xerocytosis). Am J Hematol. 2015 Oct; 90(10):921-6.
    View in: PubMed
    Score: 0.040
  59. Inhibition of WNK3 Kinase Signaling Reduces Brain Damage and Accelerates Neurological Recovery After Stroke. Stroke. 2015 Jul; 46(7):1956-1965.
    View in: PubMed
    Score: 0.039
  60. Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6.
    View in: PubMed
    Score: 0.036
  61. Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct. JAMA Otolaryngol Head Neck Surg. 2013 Sep; 139(9):907-13.
    View in: PubMed
    Score: 0.034
  62. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 09; 121(19):3925-35, S1-12.
    View in: PubMed
    Score: 0.033
  63. Missense mutations in the ABCB6 transporter cause dominant familial pseudohyperkalemia. Am J Hematol. 2013 Jan; 88(1):66-72.
    View in: PubMed
    Score: 0.033
  64. Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest. 2007 Jun; 117(6):1708-17.
    View in: PubMed
    Score: 0.022
  65. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol. 2007 May; 18(5):1408-18.
    View in: PubMed
    Score: 0.022
  66. Functional and molecular characterization of an anion exchanger in airway serous epithelial cells. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C1016-23.
    View in: PubMed
    Score: 0.014
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.