Harvard Catalyst Profiles

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Seth Leo Alper, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Seth Alper and David Vandorpe.
Connection Strength

5.645
  1. A Grammastola spatulata mechanotoxin-4 (GsMTx4)-sensitive cation channel mediates increased cation permeability in human hereditary spherocytosis of multiple genetic etiologies. Haematologica. 2021 Oct 01; 106(10):2759-2762.
    View in: PubMed
    Score: 0.998
  2. Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010 Jan 15; 5(1):e8732.
    View in: PubMed
    Score: 0.443
  3. Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides. Novartis Found Symp. 2006; 273:107-19; discussion 119-25, 261-4.
    View in: PubMed
    Score: 0.335
  4. Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiol Genomics. 2002 Feb 28; 8(2):87-98.
    View in: PubMed
    Score: 0.257
  5. The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channel. J Biol Chem. 2001 Feb 09; 276(6):4093-101.
    View in: PubMed
    Score: 0.234
  6. Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells. . 2019 08 01; 317(2):C287-C302.
    View in: PubMed
    Score: 0.212
  7. Increased Red Cell KCNN4 Activity in Sporadic Hereditary Xerocytosis Associated With Enhanced Single Channel Pressure Sensitivity of PIEZO1 Mutant V598M. Hemasphere. 2018 10; 2(5):e55.
    View in: PubMed
    Score: 0.203
  8. cDNA cloning and functional characterization of the mouse Ca2+-gated K+ channel, mIK1. Roles in regulatory volume decrease and erythroid differentiation. J Biol Chem. 1998 Aug 21; 273(34):21542-53.
    View in: PubMed
    Score: 0.201
  9. Erythrocytes from hereditary xerocytosis patients heterozygous for KCNN4 V282M exhibit increased spontaneous Gardos channel-like activity inhibited by senicapoc. Am J Hematol. 2017 06; 92(6):E108-E110.
    View in: PubMed
    Score: 0.184
  10. Extracellular Cl(-) regulates human SO4 (2-)/anion exchanger SLC26A1 by altering pH sensitivity of anion transport. Pflugers Arch. 2016 08; 468(8):1311-32.
    View in: PubMed
    Score: 0.171
  11. BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins. . 2015 Sep 01; 309(5):C332-47.
    View in: PubMed
    Score: 0.162
  12. Dehydrated stomatocytic anemia due to the heterozygous mutation R2456H in the mechanosensitive cation channel PIEZO1: a case report. Blood Cells Mol Dis. 2014 Jan; 52(1):53-4.
    View in: PubMed
    Score: 0.142
  13. Cation-leak stomatocytosis in standard schnauzers does not cosegregate with coding mutations in the RhAG, SLC4A1, or GLUT1 genes associated with human disease. Blood Cells Mol Dis. 2012 Apr 15; 48(4):219-25.
    View in: PubMed
    Score: 0.129
  14. Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem. 2011; 28(3):435-50.
    View in: PubMed
    Score: 0.126
  15. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. . 2011 Dec; 301(6):C1325-43.
    View in: PubMed
    Score: 0.124
  16. SLC26 anion exchangers of guinea pig pancreatic duct: molecular cloning and functional characterization. . 2011 Aug; 301(2):C289-303.
    View in: PubMed
    Score: 0.122
  17. Functional characterization and modified rescue of novel AE1 mutation R730C associated with overhydrated cation leak stomatocytosis. . 2011 May; 300(5):C1034-46.
    View in: PubMed
    Score: 0.119
  18. Native and recombinant Slc26a3 (downregulated in adenoma, Dra) do not exhibit properties of 2Cl-/1HCO3- exchange. . 2011 Feb; 300(2):C276-86.
    View in: PubMed
    Score: 0.117
  19. Regulated transport of sulfate and oxalate by SLC26A2/DTDST. . 2010 Jun; 298(6):C1363-75.
    View in: PubMed
    Score: 0.112
  20. The GPA-dependent, spherostomatocytosis mutant AE1 E758K induces GPA-independent, endogenous cation transport in amphibian oocytes. . 2010 Feb; 298(2):C283-97.
    View in: PubMed
    Score: 0.109
  21. Molecular characterization of Slc26a3 and Slc26a6 anion transporters in guinea pig pancreatic duct. J Med Invest. 2009; 56 Suppl:329-31.
    View in: PubMed
    Score: 0.103
  22. Reduced DIDS-sensitive chloride conductance in Ae1-/- mouse erythrocytes. Blood Cells Mol Dis. 2008 Jul-Aug; 41(1):22-34.
    View in: PubMed
    Score: 0.097
  23. Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. J Physiol. 2008 Mar 01; 586(5):1291-306.
    View in: PubMed
    Score: 0.096
  24. Increased sulfate uptake by E. coli overexpressing the SLC26-related SulP protein Rv1739c from Mycobacterium tuberculosis. Comp Biochem Physiol A Mol Integr Physiol. 2008 Mar; 149(3):255-66.
    View in: PubMed
    Score: 0.096
  25. Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. . 2008 Mar; 294(3):R1081-91.
    View in: PubMed
    Score: 0.096
  26. Apparent receptor-mediated activation of Ca2+-dependent conductive Cl- transport by shark-derived polyaminosterols. . 2005 Dec; 289(6):R1644-58.
    View in: PubMed
    Score: 0.082
  27. Expression of the polycystin-1 C-terminal cytoplasmic tail increases Cl channel activity in Xenopus oocytes. Kidney Int. 2005 Aug; 68(2):632-41.
    View in: PubMed
    Score: 0.081
  28. Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F835-49.
    View in: PubMed
    Score: 0.080
  29. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 04; 280(9):8564-80.
    View in: PubMed
    Score: 0.077
  30. Role of JNK in hypertonic activation of Cl(-)-dependent Na(+)/H(+) exchange in Xenopus oocytes. . 2001 Dec; 281(6):C1978-90.
    View in: PubMed
    Score: 0.063
  31. Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology. Nat Commun. 2020 08 28; 11(1):4328.
    View in: PubMed
    Score: 0.058
  32. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6. J Biol Chem. 2019 08 23; 294(34):12655-12669.
    View in: PubMed
    Score: 0.053
  33. The antifungal imidazole clotrimazole and its major in vivo metabolite are potent blockers of the calcium-activated potassium channel in murine erythroleukemia cells. J Membr Biol. 1997 May 15; 157(2):177-91.
    View in: PubMed
    Score: 0.046
  34. Electrogenic sulfate/chloride exchange in Xenopus oocytes mediated by murine AE1 E699Q. J Gen Physiol. 1997 Mar; 109(3):345-60.
    View in: PubMed
    Score: 0.045
  35. Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6.
    View in: PubMed
    Score: 0.038
  36. Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1. Blood. 2013 May 09; 121(19):3925-35, S1-12.
    View in: PubMed
    Score: 0.034
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.