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Amy Kathleen Barczak, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI133309 (BARCZAK, AMY K) Feb 12, 2018 - Jan 31, 2020
    NIH/NIAID
    Targeting type I interferon production in TB infection.
    Role: Principal Investigator
  2. K08AI080944 (BARCZAK, AMY K) Sep 29, 2010 - Aug 31, 2015
    NIH/NIAID
    Chemical genetic approach to cellular mechanisms of M. tuberculosis virulence.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Libardo MDJ, de la Fuente-Nuñez C, Anand K, Krishnamoorthy G, Kaiser P, Pringle SC, Dietz C, Pierce S, Smith MB, Barczak A, Kaufmann SHE, Singh A, Angeles-Boza AM. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018 Sep 06. PMID: 30141623.
    View in: PubMed
  2. Lu LL, Kwon DS, Barczak AK. Introduction: Physician-Scientists in the Evolving Landscape of Biomedical Research. J Infect Dis. 2018 Aug 14; 218(suppl_1):S1-S2. PMID: 30124978.
    View in: PubMed
  3. Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. PLoS Pathog. 2017 May; 13(5):e1006363. PMID: 28505176.
    View in: PubMed
  4. Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M. Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLoS One. 2015; 10(9):e0134544. PMID: 26348349; PMCID: PMC4562662.
  5. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871; PMCID: PMC4483258.
  6. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159; PMCID: PMC3930586.
  7. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362; PMCID: PMC3341018.
  8. Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009 Oct; 12(5):490-6. PMID: 19631578; PMCID: PMC2763366.
  9. Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res. 2005 Nov; 25(11):694-701. PMID: 16318583.
    View in: PubMed
  10. Barczak AK, Domenech P, Boshoff HI, Reed MB, Manca C, Kaplan G, Barry CE. In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis. 2005 Aug 15; 192(4):600-6. PMID: 16028128.
    View in: PubMed
  11. Reed MB, Domenech P, Manca C, Su H, Barczak AK, Kreiswirth BN, Kaplan G, Barry CE. A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature. 2004 Sep 02; 431(7004):84-7. PMID: 15343336.
    View in: PubMed
  12. Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem. 2003 Nov; 87(4):922-34. PMID: 14622123; PMCID: PMC4203348.
  13. Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE. Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300. Mol Cell Biol. 2003 Jan; 23(2):526-33. PMID: 12509451; PMCID: PMC151551.
  14. Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 02; 890(2):222-32. PMID: 11164788; PMCID: PMC4203340.
  15. Tsai EY, Falvo JV, Tsytsykova AV, Barczak AK, Reimold AM, Glimcher LH, Fenton MJ, Gordon DC, Dunn IF, Goldfeld AE. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol. 2000 Aug; 20(16):6084-94. PMID: 10913190; PMCID: PMC86084.
  16. Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J Neurosci. 2000 Jun 01; 20(11):4011-20. PMID: 10818136; PMCID: PMC4203343.
  17. Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C. L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J Neurosci. 1999 Aug 01; 19(15):6348-59. PMID: 10414964; PMCID: PMC4204489.
  18. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J Pharmacol Exp Ther. 1998 Aug; 286(2):1020-5. PMID: 9694964.
    View in: PubMed
  19. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II. Brain Res. 1998 Jun 08; 795(1-2):341-8. PMID: 9622670.
    View in: PubMed
  20. Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3215-20. PMID: 9501243; PMCID: PMC19722.
  21. Rajadhyaksha A, Leveque J, Macías W, Barczak A, Konradi C. Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Dev Neurosci. 1998; 20(2-3):204-15. PMID: 9691194.
    View in: PubMed
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