Harvard Catalyst Profiles

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Amy Kathleen Barczak, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI133309 (BARCZAK, AMY K) Feb 12, 2018 - Jan 31, 2020
    NIH/NIAID
    Targeting type I interferon production in TB infection.
    Role: Principal Investigator
  2. K08AI080944 (BARCZAK, AMY K) Sep 29, 2010 - Aug 31, 2015
    NIH/NIAID
    Chemical genetic approach to cellular mechanisms of M. tuberculosis virulence.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Libardo MDJ, de la Fuente-Nuñez C, Anand K, Krishnamoorthy G, Kaiser P, Pringle SC, Dietz C, Pierce S, Smith MB, Barczak A, Kaufmann SHE, Singh A, Angeles-Boza AM. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018 Nov 09; 4(11):1623-1634. PMID: 30141623.
    Citations:    Fields:    
  2. Lu LL, Kwon DS, Barczak AK. Introduction: Physician-Scientists in the Evolving Landscape of Biomedical Research. J Infect Dis. 2018 Aug 14; 218(suppl_1):S1-S2. PMID: 30124978.
    Citations:    Fields:    
  3. Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. PLoS Pathog. 2017 May; 13(5):e1006363. PMID: 28505176.
    Citations: 6     Fields:    Translation:AnimalsCells
  4. Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M. Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLoS One. 2015; 10(9):e0134544. PMID: 26348349.
    Citations: 1     Fields:    Translation:HumansCells
  5. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871.
    Citations: 8     Fields:    Translation:Cells
  6. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159.
    Citations: 61     Fields:    Translation:AnimalsCells
  7. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362; PMCID: PMC3341018.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  8. Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009 Oct; 12(5):490-6. PMID: 19631578; PMCID: PMC2763366.
    Citations: 27     Fields:    Translation:HumansCells
  9. Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res. 2005 Nov; 25(11):694-701. PMID: 16318583.
    Citations: 102     Fields:    Translation:AnimalsCells
  10. Barczak AK, Domenech P, Boshoff HI, Reed MB, Manca C, Kaplan G, Barry CE. In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis. 2005 Aug 15; 192(4):600-6. PMID: 16028128.
    Citations: 27     Fields:    Translation:AnimalsCells
  11. Reed MB, Domenech P, Manca C, Su H, Barczak AK, Kreiswirth BN, Kaplan G, Barry CE. A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature. 2004 Sep 02; 431(7004):84-7. PMID: 15343336.
    Citations: 247     Fields:    Translation:AnimalsCells
  12. Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem. 2003 Nov; 87(4):922-34. PMID: 14622123; PMCID: PMC4203348.
    Citations: 51     Fields:    Translation:AnimalsCells
  13. Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE. Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300. Mol Cell Biol. 2003 Jan; 23(2):526-33. PMID: 12509451; PMCID: PMC151551.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  14. Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 02; 890(2):222-32. PMID: 11164788; PMCID: PMC4203340.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Tsai EY, Falvo JV, Tsytsykova AV, Barczak AK, Reimold AM, Glimcher LH, Fenton MJ, Gordon DC, Dunn IF, Goldfeld AE. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol. 2000 Aug; 20(16):6084-94. PMID: 10913190; PMCID: PMC86084.
    Citations: 85     Fields:    Translation:AnimalsCells
  16. Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J Neurosci. 2000 Jun 01; 20(11):4011-20. PMID: 10818136; PMCID: PMC4203343.
    Citations: 34     Fields:    Translation:AnimalsCells
  17. Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C. L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J Neurosci. 1999 Aug 01; 19(15):6348-59. PMID: 10414964; PMCID: PMC4204489.
    Citations: 40     Fields:    Translation:AnimalsCells
  18. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J Pharmacol Exp Ther. 1998 Aug; 286(2):1020-5. PMID: 9694964.
    Citations: 15     Fields:    Translation:HumansCells
  19. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II. Brain Res. 1998 Jun 08; 795(1-2):341-8. PMID: 9622670.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3215-20. PMID: 9501243; PMCID: PMC19722.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Rajadhyaksha A, Leveque J, Macías W, Barczak A, Konradi C. Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Dev Neurosci. 1998; 20(2-3):204-15. PMID: 9691194.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.