Harvard Catalyst Profiles

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Amy Kathleen Barczak, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI150762 (BARCZAK, AMY K) Apr 1, 2021 - Mar 31, 2026
    NIH
    Elucidating the path to type I IFNs in TB infection
    Role: Principal Investigator
  2. R21AI146836 (BARCZAK, AMY K) Mar 2, 2020 - Feb 28, 2022
    NIH
    A proteomic approach to understanding phagosome composition in TB infection
    Role: Principal Investigator
  3. R21AI146813 (BARCZAK, AMY K) Aug 7, 2019 - Jul 31, 2021
    NIH
    Targeting MT1-MMP to inhibit pathologic inflammation in TB
    Role: Principal Investigator
  4. R21AI133309 (BARCZAK, AMY K) Feb 12, 2018 - Jan 31, 2020
    NIH
    Targeting type I interferon production in TB infection.
    Role: Principal Investigator
  5. K08AI080944 (BARCZAK, AMY K) Sep 29, 2010 - Aug 31, 2016
    NIH
    Chemical genetic approach to cellular mechanisms of M. tuberculosis virulence.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews JI, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine breakthrough infection leads to distinct profiles of neutralizing antibody responses by SARS-CoV-2 variant. JCI Insight. 2022 10 10; 7(19). PMID: 36214224; PMCID: PMC9675445.
    Citations: 1     Fields:    Translation:HumansCells
  2. Dai EY, Lee KA, Nathanson AB, Leonelli AT, Petros BA, Brock-Fisher T, Dobbins ST, MacInnis BL, Capone A, Littlehale N, Boucau J, Marino C, Barczak AK, Sabeti PC, Springer M, Stephenson KE. Viral Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Omicron Infection in mRNA-Vaccinated Individuals Treated and Not Treated with Nirmatrelvir-Ritonavir. medRxiv. 2022 Aug 04. PMID: 35982651; PMCID: PMC9387148.
    Citations:    
  3. Jani C, Barczak AK. Tag you're it: A phosphatase inhibitor changes the fate of intracellular mycobacteria. Cell Chem Biol. 2022 07 21; 29(7):1065-1067. PMID: 35868234.
    Citations:    Fields:    Translation:HumansCells
  4. Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Lipiner T, Kittilson A, Melberg M, Li Y, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Goldberg MB, Vyas JM, Li JZ, Lemieux JE, Siedner MJ, Barczak AK. Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection. N Engl J Med. 2022 07 21; 387(3):275-277. PMID: 35767428; PMCID: PMC9258747.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Boucau J, Uddin R, Marino C, Regan J, Flynn JP, Choudhary MC, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Turbett SE, Li JZ, Lemieux JE, Barczak AK, Siedner MJ. Characterization of virologic rebound following nirmatrelvir-ritonavir treatment for COVID-19. Clin Infect Dis. 2022 Jun 23. PMID: 35737946; PMCID: PMC9384370.
    Citations: 3     Fields:    
  6. Boucau J, Chew KW, Choudhary MC, Deo R, Regan J, Flynn JP, Crain CR, Hughes MD, Ritz J, Moser C, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Coombs RW, Fischer WA, Daar ES, Wohl DA, Eron JJ, Currier JS, Smith DM, Li JZ, Barczak AK. Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection. Cell Rep Med. 2022 07 19; 3(7):100678. PMID: 35793677; PMCID: PMC9213028.
    Citations:    Fields:    Translation:HumansCellsCTClinical Trials
  7. North CM, Barczak A, Goldstein RH, Healy BC, Finkelstein DM, Ding DD, Kim A, Boucau J, Shaw B, Gilbert RF, Vyas T, Reynolds Z, Siddle KJ, MacInnis BL, Regan J, Flynn JP, Choudhary MC, Vyas JM, Laskowski K, Dighe AS, Lemieux JE, Li JZ, Baden LR, Siedner MJ, Woolley AE, Sacks CA. Determining the Incidence of Asymptomatic SARS-CoV-2 Among Early Recipients of COVID-19 Vaccines (DISCOVER-COVID-19): A Prospective Cohort Study of Healthcare Workers Before, During and After Vaccination. Clin Infect Dis. 2022 04 09; 74(7):1275-1278. PMID: 34363462; PMCID: PMC8436402.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  8. Seaman MS, Siedner MJ, Boucau J, Lavine CL, Ghantous F, Liew MY, Mathews J, Singh A, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Lipiner T, Kittilson A, Melberg M, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Vyas JM, Goldberg MB, Luban J, Li JZ, Barczak AK, Lemieux JE. Vaccine Breakthrough Infection with the SARS-CoV-2 Delta or Omicron (BA.1) Variant Leads to Distinct Profiles of Neutralizing Antibody Responses. medRxiv. 2022 Mar 03. PMID: 35262094; PMCID: PMC8902886.
    Citations: 1     
  9. Boucau J, Marino C, Regan J, Uddin R, Choudhary MC, Flynn JP, Chen G, Stuckwisch AM, Mathews J, Liew MY, Singh A, Lipiner T, Kittilson A, Melberg M, Li Y, Gilbert RF, Reynolds Z, Iyer SL, Chamberlin GC, Vyas TD, Goldberg MB, Vyas JM, Li JZ, Lemieux JE, Siedner MJ, Barczak AK. Duration of viable virus shedding in SARS-CoV-2 omicron variant infection. medRxiv. 2022 Mar 02. PMID: 35262089; PMCID: PMC8902872.
    Citations:    
  10. Regan J, Flynn JP, Choudhary MC, Uddin R, Lemieux J, Boucau J, Bhattacharyya RP, Barczak AK, Li JZ, Siedner MJ. Detection of the Omicron Variant Virus With the Abbott BinaxNow SARS-CoV-2 Rapid Antigen Assay. Open Forum Infect Dis. 2022 Mar; 9(3):ofac022. PMID: 35169591; PMCID: PMC8842316.
    Citations: 7     
  11. Siedner MJ, Boucau J, Gilbert RF, Uddin R, Luu J, Haneuse S, Vyas T, Reynolds Z, Iyer S, Chamberlin GC, Goldstein RH, North CM, Sacks CA, Regan J, Flynn JP, Choudhary MC, Vyas JM, Barczak AK, Lemieux JE, Li JZ. Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections. JCI Insight. 2022 01 25; 7(2). PMID: 34871181; PMCID: PMC8855795.
    Citations: 10     Fields:    Translation:HumansCells
  12. Boucau J, Chew KW, Choudhary M, Deo R, Regan J, Flynn JP, Crain CR, Hughes MD, Ritz J, Moser C, Dragavon JA, Javan AC, Nirula A, Klekotka P, Greninger AL, Coombs RW, Fischer WA, Daar ES, Wohl DA, Eron JJ, Currier JS, Smith DM, Li JZ, Barczak AK. Monoclonal antibody treatment drives rapid culture conversion in SARS-CoV-2 infection. medRxiv. 2021 Dec 30. PMID: 35018382; PMCID: PMC8750705.
    Citations: 1     
  13. Yonker LM, Boucau J, Regan J, Choudhary MC, Burns MD, Young N, Farkas EJ, Davis JP, Moschovis PP, Bernard Kinane T, Fasano A, Neilan AM, Li JZ, Barczak AK. Virologic Features of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Children. J Infect Dis. 2021 12 01; 224(11):1821-1829. PMID: 34647601; PMCID: PMC8643403.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  14. Hinman AE, Jani C, Pringle SC, Zhang WR, Jain N, Martinot AJ, Barczak AK. Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response. Elife. 2021 11 10; 10. PMID: 34755600; PMCID: PMC8610422.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Yonker LM, Boucau J, Regan J, Choudhary MC, Burns MD, Young N, Farkas EJ, Davis JP, Moschovis PP, Kinane TB, Fasano A, Neilan AM, Li JZ, Barczak AK. Virologic features of SARS-CoV-2 infection in children. medRxiv. 2021 Aug 17. PMID: 34124714; PMCID: PMC8193793.
    Citations:    
  16. Bebell LM, Gonzalez RG, Barczak AK, Anahtar MN. Case 1-2021: A 76-Year-Old Woman with Lethargy and Altered Mental Status. N Engl J Med. 2021 Jan 14; 384(2):166-176. PMID: 33497551.
    Citations:    Fields:    Translation:HumansCells
  17. Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293. PMID: 33176080; PMCID: PMC7673303.
    Citations: 363     Fields:    Translation:HumansCells
  18. Lazarus JE, Branda JA, Gandhi RG, Barshak MB, Zachary KC, Barczak AK. Disseminated Intravascular Infection Caused by Paecilomyces variotii: Case Report and Review of the Literature. Open Forum Infect Dis. 2020 Jun; 7(6):ofaa166. PMID: 32617367; PMCID: PMC7314584.
    Citations:    
  19. Oberfeld B, Achanta A, Carpenter K, Chen P, Gilette NM, Langat P, Said JT, Schiff AE, Zhou AS, Barczak AK, Pillai S. SnapShot: COVID-19. Cell. 2020 May 14; 181(4):954-954.e1. PMID: 32413300; PMCID: PMC7190493.
    Citations: 58     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  20. Libardo MDJ, de la Fuente-Nuñez C, Anand K, Krishnamoorthy G, Kaiser P, Pringle SC, Dietz C, Pierce S, Smith MB, Barczak A, Kaufmann SHE, Singh A, Angeles-Boza AM. Phagosomal Copper-Promoted Oxidative Attack on Intracellular Mycobacterium tuberculosis. ACS Infect Dis. 2018 11 09; 4(11):1623-1634. PMID: 30141623.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Lu LL, Kwon DS, Barczak AK. Introduction: Physician-Scientists in the Evolving Landscape of Biomedical Research. J Infect Dis. 2018 08 14; 218(suppl_1):S1-S2. PMID: 30124978; PMCID: PMC7191613.
    Citations: 1     Fields:    Translation:Humans
  22. Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT. Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence. PLoS Pathog. 2017 May; 13(5):e1006363. PMID: 28505176; PMCID: PMC5444860.
    Citations: 40     Fields:    Translation:AnimalsCells
  23. Dragset MS, Barczak AK, Kannan N, Mærk M, Flo TH, Valla S, Rubin EJ, Steigedal M. Benzoic Acid-Inducible Gene Expression in Mycobacteria. PLoS One. 2015; 10(9):e0134544. PMID: 26348349.
    Citations: 3     Fields:    Translation:HumansCells
  24. Kieser KJ, Boutte CC, Kester JC, Baer CE, Barczak AK, Meniche X, Chao MC, Rego EH, Sassetti CM, Fortune SM, Rubin EJ. Phosphorylation of the Peptidoglycan Synthase PonA1 Governs the Rate of Polar Elongation in Mycobacteria. PLoS Pathog. 2015 Jun; 11(6):e1005010. PMID: 26114871.
    Citations: 42     Fields:    Translation:Cells
  25. Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 2014 Feb; 10(2):e1003946. PMID: 24586159.
    Citations: 134     Fields:    Translation:AnimalsCells
  26. Barczak AK, Gomez JE, Kaufmann BB, Hinson ER, Cosimi L, Borowsky ML, Onderdonk AB, Stanley SA, Kaur D, Bryant KF, Knipe DM, Sloutsky A, Hung DT. RNA signatures allow rapid identification of pathogens and antibiotic susceptibilities. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6217-22. PMID: 22474362.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  27. Barczak AK, Hung DT. Productive steps toward an antimicrobial targeting virulence. Curr Opin Microbiol. 2009 Oct; 12(5):490-6. PMID: 19631578.
    Citations: 35     Fields:    Translation:HumansCells
  28. Manca C, Tsenova L, Freeman S, Barczak AK, Tovey M, Murray PJ, Barry C, Kaplan G. Hypervirulent M. tuberculosis W/Beijing strains upregulate type I IFNs and increase expression of negative regulators of the Jak-Stat pathway. J Interferon Cytokine Res. 2005 Nov; 25(11):694-701. PMID: 16318583.
    Citations: 158     Fields:    Translation:AnimalsCells
  29. Barczak AK, Domenech P, Boshoff HI, Reed MB, Manca C, Kaplan G, Barry CE. In vivo phenotypic dominance in mouse mixed infections with Mycobacterium tuberculosis clinical isolates. J Infect Dis. 2005 Aug 15; 192(4):600-6. PMID: 16028128.
    Citations: 33     Fields:    Translation:AnimalsCells
  30. Reed MB, Domenech P, Manca C, Su H, Barczak AK, Kreiswirth BN, Kaplan G, Barry CE. A glycolipid of hypervirulent tuberculosis strains that inhibits the innate immune response. Nature. 2004 Sep 02; 431(7004):84-7. PMID: 15343336.
    Citations: 307     Fields:    Translation:AnimalsCells
  31. Dudman JT, Eaton ME, Rajadhyaksha A, Macías W, Taher M, Barczak A, Kameyama K, Huganir R, Konradi C. Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897-NR1. J Neurochem. 2003 Nov; 87(4):922-34. PMID: 14622123; PMCID: PMC4203348.
    Citations: 63     Fields:    Translation:AnimalsCells
  32. Barthel R, Tsytsykova AV, Barczak AK, Tsai EY, Dascher CC, Brenner MB, Goldfeld AE. Regulation of tumor necrosis factor alpha gene expression by mycobacteria involves the assembly of a unique enhanceosome dependent on the coactivator proteins CBP/p300. Mol Cell Biol. 2003 Jan; 23(2):526-33. PMID: 12509451.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  33. Macías W, Carlson R, Rajadhyaksha A, Barczak A, Konradi C. Potassium chloride depolarization mediates CREB phosphorylation in striatal neurons in an NMDA receptor-dependent manner. Brain Res. 2001 Feb 02; 890(2):222-32. PMID: 11164788; PMCID: PMC4203340.
    Citations: 12     Fields:    Translation:AnimalsCells
  34. Tsai EY, Falvo JV, Tsytsykova AV, Barczak AK, Reimold AM, Glimcher LH, Fenton MJ, Gordon DC, Dunn IF, Goldfeld AE. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor alpha promoter in vivo. Mol Cell Biol. 2000 Aug; 20(16):6084-94. PMID: 10913190.
    Citations: 98     Fields:    Translation:AnimalsCells
  35. Leveque JC, Macías W, Rajadhyaksha A, Carlson RR, Barczak A, Kang S, Li XM, Coyle JT, Huganir RL, Heckers S, Konradi C. Intracellular modulation of NMDA receptor function by antipsychotic drugs. J Neurosci. 2000 Jun 01; 20(11):4011-20. PMID: 10818136; PMCID: PMC4203343.
    Citations: 43     Fields:    Translation:AnimalsCells
  36. Rajadhyaksha A, Barczak A, Macías W, Leveque JC, Lewis SE, Konradi C. L-Type Ca(2+) channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal neurons. J Neurosci. 1999 Aug 01; 19(15):6348-59. PMID: 10414964; PMCID: PMC4204489.
    Citations: 57     Fields:    Translation:AnimalsCells
  37. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Molecular characterization of human brain N-acetylated alpha-linked acidic dipeptidase (NAALADase). J Pharmacol Exp Ther. 1998 Aug; 286(2):1020-5. PMID: 9694964.
    Citations: 23     Fields:    Translation:HumansCells
  38. Luthi-Carter R, Barczak AK, Speno H, Coyle JT. Hydrolysis of the neuropeptide N-acetylaspartylglutamate (NAAG) by cloned human glutamate carboxypeptidase II. Brain Res. 1998 Jun 08; 795(1-2):341-8. PMID: 9622670.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  39. Luthi-Carter R, Berger UV, Barczak AK, Enna M, Coyle JT. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):3215-20. PMID: 9501243; PMCID: PMC19722.
    Citations: 13     Fields:    Translation:AnimalsCells
  40. Rajadhyaksha A, Leveque J, Macías W, Barczak A, Konradi C. Molecular components of striatal plasticity: the various routes of cyclic AMP pathways. Dev Neurosci. 1998; 20(2-3):204-15. PMID: 9691194; PMCID: PMC4205584.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.