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Timothy P. Padera, Ph.D.


Martin Research Prize for Excellence in Clinical Research
NIH Director's New Innovator Award

As part of the Edwin L. Steele Laboratories for Tumor Biology, the Padera Laboratory examines the function of lymphatic vessels in health and disease, with an emphasis on the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis. Lymphatic vessels are responsible for draining interstitial fluid from tissues and for transporting immune cells to lymph nodes to maintain the body's immune surveillance. Lymphatic vessels also facilitate the dissemination of cancer cells from a primary tumor to regional lymph nodes. The mechanisms used by cancer cells to form lymph node metastasis are starting to be understood, with the hope of identifying treatment strategies to lower mortality due to disseminated cancer. In contrast to hematogenous metastasis, in which the primary tumor has functional blood vessels for cancer cells to invade, the story for lymphatic metastasis is likely more complicated as solid tumors seem to lack functional intratumor lymphatic vessels. Functional lymphatic vessels in the margin of tumors, however, seem sufficient for lymphatic metastasis to occur.

Using intravital microscopy, we have investigated the individual steps of lymphatic metastasis. We can monitor lymphatic vessels in the tumor margin, observe tumor cells moving in lymphatic vessels, measure lymph flow and quantify the number of tumor cells that arrive in the draining lymph node. Our studies have shown that VEGF-C, which is associated with lymphatic metastasis in patients, increases the size of the tumor margin lymphatic vessels, making them more vulnerable to invasion. Our data suggests that VEGF-C needs to be blocked very early in the metastatic process to be able to reduce VEGF-C enhanced lymphatic metastasis.

In addition to our work on metastasis, we have studied the molecular mechanisms that regulate the autonomous lymphatic contractions that drive lymph flow. Using novel animal models and intravital microscopy, we have shown that normal lymphatic contractions are reliant upon nitric oxide that is produced in specific locations at specific times. When the spatial and temporal control is lost during inflammation, the contractions stop and lymph function is impaired.

Our future studies will continue to dissect the physical and molecular determinants of lymphatic vessel function and lymphangiogenesis in both normal and disease states. In addition we will continue to understand the mechanisms of cancer dissemination through lymphatic vessels and subsequent growth in lymph nodes. Through the use of our novel imaging technologies and animal models, we will answer timely questions that can lead to the development of treatments for lymphatic metastasis and lymphedema.

Available: 09/02/19, Expires: 09/02/21

Lymph nodes are central to the generation of adaptive immune responses by bringing together antigen presenting cells and lymphocytes. The ability of lymphocytes to survey and identify foreign or dangerous antigen relies upon close contact with antigen presenting cells, which is provided by the lymph node architecture. Amongst this immune activity, metastatic cancer cells can evade immune detection in the lymph node, which is the most frequent site of metastatic cancer. Further, as metastatic lesions grow in the lymph node, they disrupt the lymph node microarchitecture that facilitates lymphocyte activation. How cancer cells evade immune detection in lymph node is not known. We are actively exploring how metastatic lesions can form in lymph nodes, how immune reactions are suppressed and the consequences of this lymph node suppression for systemic anti-tumor immune responses and immunotherapy. Students will use biochemical, cell biology and small animal techniques alongside intravital microscopy to address these questions.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI135092 (PADERA, TIMOTHY P) Jun 1, 2018 - May 31, 2020
    Mechanism of methicillin-resistant Staphylococcus aureus induced lymphatic dysfunction
    Role: Principal Investigator
  2. R01CA214913 (PADERA, TIMOTHY P) Mar 2, 2017 - Feb 28, 2022
    Targeting lymph node metastases to prevent cancer progression
    Role: Principal Investigator
  3. R01HL128168 (MUNN, LANCE L) Aug 1, 2015 - May 31, 2020
    Systems biology of lymphatic transport
    Role: Co-Principal Investigator
  4. R21AI097745 (PADERA, TIMOTHY P.) Feb 15, 2012 - Jan 31, 2015
    Characterization of lymphatic contraction during infection
    Role: Principal Investigator
  5. DP2OD008780 (PADERA, TIMOTHY P.) Sep 30, 2011 - Jun 30, 2016
    Characterizing lymphatic micrometastases: prognostic and therapeutic implications
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Meijer EF, Bouta EM, Mendonca C, Skolny MN, Salama LW, Taghian AG, Padera TP. A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema. Clin Res Trials. 2020 Feb; 6(1). PMID: 32864167.
  2. Tamburini BAJ, Padera TP, Lund AW. Editorial: Regulation of Immune Function by the Lymphatic Vasculature. Front Immunol. 2019; 10:2597. PMID: 31781105.
  3. Granoff MD, Johnson AR, Lee BT, Padera TP, Bouta EM, Singhal D. A Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography. Plast Reconstr Surg. 2019 11; 144(5):1197-1201. PMID: 31688768.
  4. Li H, Mei Y, Maimon N, Padera TP, Baish JW, Munn LL. The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations. Sci Rep. 2019 07 23; 9(1):10649. PMID: 31337769.
  5. Ruscic KJ, Padera TP. Silence of the lymphs: some anaesthetic regimens inhibit lymphatic pumping. J Physiol. 2019 06; 597(11):2827-2828. PMID: 31032908.
  6. Johnson AR, Granoff MD, Lee BT, Padera TP, Bouta EM, Singhal D. The Impact of Taxane-based Chemotherapy on the Lymphatic System. Ann Plast Surg. 2019 04; 82(4S Suppl 3):S173-S178. PMID: 30855384.
  7. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245. PMID: 30948807.
  8. Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP. Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Lymphat Res Biol. 2019 06; 17(3):294-300. PMID: 30358484.
    Citations:    Fields:    
  9. Firl DJ, Degn SE, Padera T, Carroll MC. Capturing change in clonal composition amongst single mouse germinal centers. Elife. 2018 08 01; 7. PMID: 30066671.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Nathanson SD, Krag D, Kuerer HM, Newman LA, Brown M, Kerjaschki D, Pereira ER, Padera TP. Breast cancer metastasis through the lympho-vascular system. Clin Exp Metastasis. 2018 08; 35(5-6):443-454. PMID: 29796854.
    Citations: 1     Fields:    
  11. Bourquard A, Pablo-Trinidad A, Butterworth I, Sánchez-Ferro Á, Cerrato C, Humala K, Fabra Urdiola M, Del Rio C, Valles B, Tucker-Schwartz JM, Lee ES, Vakoc BJ, Padera TP, Ledesma-Carbayo MJ, Chen YB, Hochberg EP, Gray ML, Castro-González C. Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation. Sci Rep. 2018 03 28; 8(1):5301. PMID: 29593221.
    Citations:    Fields:    
  12. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018 03 23; 359(6382):1403-1407. PMID: 29567713.
    Citations: 9     Fields:    Translation:AnimalsCells
  13. Jones D, Pereira ER, Padera TP. Growth and Immune Evasion of Lymph Node Metastasis. Front Oncol. 2018; 8:36. PMID: 29527513.
  14. Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TP. Lymphatic function measurements influenced by contrast agent volume and body position. JCI Insight. 2018 01 25; 3(2). PMID: 29367467.
    Citations:    Fields:    
  15. Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP. Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med. 2018 01 17; 10(424). PMID: 29343625.
    Citations: 1     Fields:    
  16. Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10455-10460. PMID: 28900008.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP. Lymph node effective vascular permeability and chemotherapy uptake. Microcirculation. 2017 08; 24(6). PMID: 28510992.
    Citations: 1     Fields:    Translation:Animals
  18. Blatter C, Meijer EFJ, Padera TP, Vakoc BJ. Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. J Biophotonics. 2018 08; 11(8):e201700017. PMID: 28700145.
    Citations: 2     Fields:    
  19. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE. Depolarization signatures map gold nanorods within biological tissue. Nat Photonics. 2017; 11:583-588. PMID: 29201136.
    Citations: 2     
  20. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. J Clin Invest. 2017 Aug 01; 127(8):3039-3051. PMID: 28691930.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP. Murine chronic lymph node window for longitudinal intravital lymph node imaging. Nat Protoc. 2017 Aug; 12(8):1513-1520. PMID: 28683064.
    Citations: 4     Fields:    Translation:Animals
  22. Baish JW, Kunert C, Padera TP, Munn LL. Synchronization and Random Triggering of Lymphatic Vessel Contractions. PLoS Comput Biol. 2016 12; 12(12):e1005231. PMID: 27935958.
    Citations: 2     Fields:    Translation:Animals
  23. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1. PMID: 28966873.
    Citations: 15     
  24. Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ. In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. Sci Rep. 2016 07 05; 6:29035. PMID: 27377852.
    Citations: 7     Fields:    Translation:Animals
  25. Padera TP, Meijer EF, Munn LL. The Lymphatic System in Disease Processes and Cancer Progression. Annu Rev Biomed Eng. 2016 07 11; 18:125-58. PMID: 26863922.
    Citations: 5     Fields:    Translation:HumansAnimals
  26. Meijer EF, Baish JW, Padera TP, Fukumura D. Measuring Vascular Permeability In Vivo. Methods Mol Biol. 2016; 1458:71-85. PMID: 27581015.
    Citations: 1     Fields:    Translation:HumansAnimals
  27. Kunert C, Baish JW, Liao S, Padera TP, Munn LL. Reply to Davis: Nitric oxide regulates lymphatic contractions. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E106. PMID: 26719425.
    Citations: 1     Fields:    Translation:Humans
  28. Kunert C, Baish JW, Liao S, Padera TP, Munn LL. Mechanobiological oscillators control lymph flow. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10938-43. PMID: 26283382.
    Citations: 15     Fields:    Translation:HumansCells
  29. Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP. Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. J Natl Cancer Inst. 2015 Sep; 107(9). PMID: 26063793.
    Citations: 30     Fields:    Translation:HumansAnimals
  30. Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP. Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. FASEB J. 2015 Sep; 29(9):3668-77. PMID: 25977256.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  31. Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI. Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):358-67. PMID: 25864172.
    Citations: 1     Fields:    Translation:Humans
  32. Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS. Significance of lymph node metastasis in cancer dissemination of head and neck cancer. Transl Oncol. 2015 Apr; 8(2):119-25. PMID: 25926078.
    Citations: 3     
  33. Padera TP. Editorial: rapid growth in the field of lymphatic biology. Semin Cell Dev Biol. 2015 Feb; 38:53-4. PMID: 25868083.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Pereira ER, Jones D, Jung K, Padera TP. The lymph node microenvironment and its role in the progression of metastatic cancer. Semin Cell Dev Biol. 2015 Feb; 38:98-105. PMID: 25620792.
    Citations: 22     Fields:    Translation:HumansAnimals
  35. Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP. Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation. Radiat Oncol. 2015 Jan 09; 10:5. PMID: 25573181.
    Citations: 4     Fields:    Translation:Humans
  36. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5. PMID: 25026209.
    Citations: 35     Fields:    Translation:Animals
  37. Munn LL, Padera TP. Imaging the lymphatic system. Microvasc Res. 2014 Nov; 96:55-63. PMID: 24956510.
    Citations: 9     Fields:    Translation:HumansAnimals
  38. Liao S, Jones D, Cheng G, Padera TP. Method for the quantitative measurement of collecting lymphatic vessel contraction in mice. J Biol Methods. 2014; 1(2). PMID: 25512945.
    Citations: 6     
  39. Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH. Novel molecular pathways in Gorham disease: implications for treatment. Pediatr Blood Cancer. 2014 Mar; 61(3):401-6. PMID: 24214028.
    Citations: 2     Fields:    Translation:Humans
  40. Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP. Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Angiogenesis. 2014 Apr; 17(2):419-27. PMID: 24201897.
    Citations: 5     Fields:    Translation:HumansCells
  41. Liao S, Padera TP. Lymphatic function and immune regulation in health and disease. Lymphat Res Biol. 2013 Sep; 11(3):136-43. PMID: 24024577.
    Citations: 11     Fields:    Translation:HumansAnimals
  42. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst. 2013 Aug 21; 105(16):1188-201. PMID: 23899555.
    Citations: 31     Fields:    Translation:AnimalsCells
  43. Kesler CT, Liao S, Munn LL, Padera TP. Lymphatic vessels in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb; 5(1):111-24. PMID: 23209022.
    Citations: 18     Fields:    Translation:HumansAnimals
  44. Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK. Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 2012; 1(1). PMID: 24353926.
    Citations: 10     
  45. Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9. PMID: 22065738.
    Citations: 80     Fields:    Translation:AnimalsCells
  46. Liao S, Padera TP, Jain RK. Notch leads lymphatics and links them to blood vessels. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1682-3. PMID: 20720193.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010 Sep 23; 116(12):2173-82. PMID: 20566898.
    Citations: 31     Fields:    Translation:AnimalsCellsPHPublic Health
  48. Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009 Oct; 15(10):1219-23. PMID: 19749772.
    Citations: 207     Fields:    Translation:HumansAnimals
  49. Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med. 2009 Jul 23; 361(4):358-67. PMID: 19587327.
    Citations: 100     Fields:    Translation:Humans
  50. Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 2009 Jul 08; 97(1):330-6. PMID: 19580771.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  51. Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK. Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol. 2009 May; 219(2):430-7. PMID: 19170073.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009 Apr 01; 69(7):2801-8. PMID: 19318557.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  53. Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5. PMID: 19151720.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  54. Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol Cancer Ther. 2008 Aug; 7(8):2272-9. PMID: 18687659.
    Citations: 39     Fields:    Translation:AnimalsCells
  55. Padera TP, Jain RK. VEGFR3: a new target for antiangiogenesis therapy? Dev Cell. 2008 Aug; 15(2):178-9. PMID: 18694556.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  56. Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia. 2007 Dec; 9(12):1038-45. PMID: 18084611.
    Citations: 14     Fields:    Translation:HumansCells
  57. Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK. Anti-VEGFR-3 therapy and lymph node metastasis [corrected]. Cancer Res. 2007 May 15; 67(10):5055; author reply 5056. PMID: 17510438.
    Citations:    Fields:    Translation:Animals
  58. Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH. Platelet-derived growth factor receptor-beta in Gorham's disease. Nat Clin Pract Oncol. 2006 Dec; 3(12):693-7. PMID: 17139320.
    Citations: 18     Fields:    Translation:Humans
  59. Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res. 2006 Aug 15; 66(16):8065-75. PMID: 16912183.
    Citations: 116     Fields:    Translation:AnimalsCells
  60. Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K. Molecular mechanisms of metastasis. Cancer Metastasis Rev. 2006 Jun; 25(2):203-20. PMID: 16770533.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  61. Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 01; 66(7):3360-4. PMID: 16585153.
    Citations: 43     Fields:    Translation:AnimalsCells
  62. Hagendoorn J, Padera TP, Fukumura D, Jain RK. Molecular regulation of microlymphatic formation and function: role of nitric oxide. Trends Cardiovasc Med. 2005 Jul; 15(5):169-73. PMID: 16165013.
    Citations: 6     Fields:    Translation:HumansAnimals
  63. Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res. 2004 Jul 01; 64(13):4400-4. PMID: 15231646.
    Citations: 46     Fields:    Translation:Animals
  64. Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res. 2004 Jul 23; 95(2):204-9. PMID: 15192027.
    Citations: 35     Fields:    Translation:Animals
  65. Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Pathology: cancer cells compress intratumour vessels. Nature. 2004 Feb 19; 427(6976):695. PMID: 14973470.
    Citations: 171     Fields:    Translation:HumansAnimals
  66. Padera TP, Boucher Y, Jain RK. Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003. Cancer Res. 2003 Dec 01; 63(23):8555-6; author reply 8558. PMID: 14679026.
    Citations: 2     Fields:    Translation:Humans
  67. Jain RK, Padera TP. Development. Lymphatics make the break. Science. 2003 Jan 10; 299(5604):209-10. PMID: 12522236.
    Citations: 6     Fields:    Translation:AnimalsCells
  68. Jain RK, Padera TP. Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy. J Natl Cancer Inst. 2002 Jun 05; 94(11):785-7. PMID: 12048260.
    Citations: 7     Fields:    Translation:HumansAnimals
  69. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6. PMID: 11976409.
    Citations: 226     Fields:    Translation:HumansAnimalsCells
  70. Padera TP, Stoll BR, So PT, Jain RK. Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions. Mol Imaging. 2002 Jan-Mar; 1(1):9-15. PMID: 12920856.
    Citations: 25     Fields:    Translation:AnimalsCells
  71. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001 Nov 15; 61(22):8079-84. PMID: 11719431.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  72. Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res. 2001 Mar 15; 61(6):2404-8. PMID: 11289105.
    Citations: 20     Fields:    Translation:AnimalsCells
  73. Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res. 2000 Aug 15; 60(16):4556-60. PMID: 10969807.
    Citations: 19     Fields:    Translation:Animals
  74. Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK. Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors. Cancer Res. 2000 Mar 01; 60(5):1442-8. PMID: 10728711.
    Citations: 18     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.