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Timothy P. Padera, Ph.D.

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Department
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Biography
2010
Martin Research Prize for Excellence in Clinical Research
2011
NIH Director's New Innovator Award

Overview
As part of the Edwin L. Steele Laboratories for Tumor Biology, the Padera Laboratory examines the function of lymphatic vessels in health and disease, with an emphasis on the pathophysiology of tumor associated lymphatic vessels and lymphatic metastasis. Lymphatic vessels are responsible for draining interstitial fluid from tissues and for transporting immune cells to lymph nodes to maintain the body's immune surveillance. Lymphatic vessels also facilitate the dissemination of cancer cells from a primary tumor to regional lymph nodes. The mechanisms used by cancer cells to form lymph node metastasis are starting to be understood, with the hope of identifying treatment strategies to lower mortality due to disseminated cancer. In contrast to hematogenous metastasis, in which the primary tumor has functional blood vessels for cancer cells to invade, the story for lymphatic metastasis is likely more complicated as solid tumors seem to lack functional intratumor lymphatic vessels. Functional lymphatic vessels in the margin of tumors, however, seem sufficient for lymphatic metastasis to occur.

Using intravital microscopy, we have investigated the individual steps of lymphatic metastasis. We can monitor lymphatic vessels in the tumor margin, observe tumor cells moving in lymphatic vessels, measure lymph flow and quantify the number of tumor cells that arrive in the draining lymph node. Our studies have shown that VEGF-C, which is associated with lymphatic metastasis in patients, increases the size of the tumor margin lymphatic vessels, making them more vulnerable to invasion. Our data suggests that VEGF-C needs to be blocked very early in the metastatic process to be able to reduce VEGF-C enhanced lymphatic metastasis.

In addition to our work on metastasis, we have studied the molecular mechanisms that regulate the autonomous lymphatic contractions that drive lymph flow. Using novel animal models and intravital microscopy, we have shown that normal lymphatic contractions are reliant upon nitric oxide that is produced in specific locations at specific times. When the spatial and temporal control is lost during inflammation, the contractions stop and lymph function is impaired.

Our future studies will continue to dissect the physical and molecular determinants of lymphatic vessel function and lymphangiogenesis in both normal and disease states. In addition we will continue to understand the mechanisms of cancer dissemination through lymphatic vessels and subsequent growth in lymph nodes. Through the use of our novel imaging technologies and animal models, we will answer timely questions that can lead to the development of treatments for lymphatic metastasis and lymphedema.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI135092 (PADERA, TIMOTHY P) Jun 1, 2018 - May 31, 2020
    NIH
    Mechanism of methicillin-resistant Staphylococcus aureus induced lymphatic dysfunction
    Role: Principal Investigator
  2. R01CA214913 (PADERA, TIMOTHY P) Mar 2, 2017 - Feb 28, 2022
    NIH
    Targeting lymph node metastases to prevent cancer progression
    Role: Principal Investigator
  3. R01HL128168 (MUNN, LANCE L) Aug 1, 2015 - Nov 30, 2020
    NIH
    Systems biology of lymphatic transport
    Role: Co-Principal Investigator
  4. R21AI097745 (PADERA, TIMOTHY P) Feb 15, 2012 - Jan 31, 2015
    NIH
    Characterization of lymphatic contraction during infection
    Role: Principal Investigator
  5. DP2OD008780 (PADERA, TIMOTHY P.) Sep 30, 2011 - Jun 30, 2016
    NIH
    Characterizing lymphatic micrometastases: prognostic and therapeutic implications
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Martin JD, Lanning RM, Chauhan VP, Martin MR, Mousa AS, Kamoun WS, Han HS, Lee H, Stylianopoulos T, Bawendi MG, Duda DG, Brown EB, Padera TP, Fukumura D, Jain RK. Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. Clin Cancer Res. 2022 07 15; 28(14):3076-3090. PMID: 35584239; PMCID: PMC9355624.
    Citations: 1     Fields:    Translation:Animals
  2. van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, Borel Rinkes IHM, Hagendoorn J. Liver lymphatic drainage patterns follow segmental anatomy. Br J Surg. 2022 05 16; 109(6):559-560. PMID: 35576376.
    Citations:    Fields:    Translation:Humans
  3. van den Bent L, Frenkel NC, Poghosyan S, Molenaar IQ, Padera TP, Kranenburg O, Borel Rinkes IHM, Hagendoorn J. Liver lymphatic drainage patterns follow segmental anatomy. Br J Surg. 2022 Mar 30. PMID: 35352802.
    Citations:    Fields:    
  4. Baish JW, Padera TP, Munn LL. The effects of gravity and compression on interstitial fluid transport in the lower limb. Sci Rep. 2022 03 22; 12(1):4890. PMID: 35318426; PMCID: PMC8941011.
    Citations:    Fields:    Translation:HumansCells
  5. Silva M, Kato Y, Melo MB, Phung I, Freeman BL, Li Z, Roh K, Van Wijnbergen JW, Watkins H, Enemuo CA, Hartwell BL, Chang JYH, Xiao S, Rodrigues KA, Cirelli KM, Li N, Haupt S, Aung A, Cossette B, Abraham W, Kataria S, Bastidas R, Bhiman J, Linde C, Bloom NI, Groschel B, Georgeson E, Phelps N, Thomas A, Bals J, Carnathan DG, Lingwood D, Burton DR, Alter G, Padera TP, Belcher AM, Schief WR, Silvestri G, Ruprecht RM, Crotty S, Irvine DJ. A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity. Sci Immunol. 2021 Dec 03; 6(66):eabf1152. PMID: 34860581; PMCID: PMC8763571.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Keahey P, Si P, Razavi M, Yu S, Lippok N, Villiger M, Padera TP, de la Zerda A, Bouma B. Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography. Nano Lett. 2021 10 27; 21(20):8595-8601. PMID: 34644094; PMCID: PMC8555503.
    Citations: 2     Fields:    Translation:Animals
  7. Jones D, Wang Z, Chen IX, Zhang S, Banerji R, Lei PJ, Zhou H, Xiao V, Kwong C, van Wijnbergen JWM, Pereira ER, Vakoc BJ, Huang P, Nia HT, Padera TP. Solid stress impairs lymphocyte infiltration into lymph-node metastases. Nat Biomed Eng. 2021 12; 5(12):1426-1436. PMID: 34282290; PMCID: PMC8678215.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Nathanson SD, Detmar M, Padera TP, Yates LR, Welch DR, Beadnell TC, Scheid AD, Wrenn ED, Cheung K. Mechanisms of breast cancer metastasis. Clin Exp Metastasis. 2022 02; 39(1):117-137. PMID: 33950409; PMCID: PMC8568733.
    Citations: 4     Fields:    Translation:Humans
  9. Zhou H, Lei PJ, Padera TP. Progression of Metastasis through Lymphatic System. Cells. 2021 03 12; 10(3). PMID: 33808959; PMCID: PMC7999434.
    Citations: 8     Fields:    Translation:HumansAnimals
  10. Pereira ER, Kedrin D, Padera TP. Fate Mapping of Cancer Cells in Metastatic Lymph Nodes Using Photoconvertible Proteins. Methods Mol Biol. 2021; 2265:363-376. PMID: 33704727; PMCID: PMC8924909.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Frenkel NC, Poghosyan S, Verheem A, Padera TP, Rinkes IHMB, Kranenburg O, Hagendoorn J. Liver lymphatic drainage patterns follow segmental anatomy in a murine model. Sci Rep. 2020 12 11; 10(1):21808. PMID: 33311587.
    Citations: 2     Fields:    Translation:Animals
  12. Meijer EF, Bouta EM, Mendonca C, Skolny MN, Salama LW, Taghian AG, Padera TP. A retrospective analysis of commonly prescribed medications and the risk of developing breast cancer related lymphedema. Clin Res Trials. 2020 Feb; 6(1). PMID: 32864167; PMCID: PMC7455025.
    Citations: 2     
  13. Tamburini BAJ, Padera TP, Lund AW. Editorial: Regulation of Immune Function by the Lymphatic Vasculature. Front Immunol. 2019; 10:2597. PMID: 31781105.
    Citations: 1     Fields:    Translation:Cells
  14. Granoff MD, Johnson AR, Lee BT, Padera TP, Bouta EM, Singhal D. A Novel Approach to Quantifying Lymphatic Contractility during Indocyanine Green Lymphangiography. Plast Reconstr Surg. 2019 11; 144(5):1197-1201. PMID: 31688768.
    Citations: 1     Fields:    Translation:Humans
  15. Li H, Mei Y, Maimon N, Padera TP, Baish JW, Munn LL. The effects of valve leaflet mechanics on lymphatic pumping assessed using numerical simulations. Sci Rep. 2019 07 23; 9(1):10649. PMID: 31337769.
    Citations: 2     Fields:    Translation:Cells
  16. Ruscic KJ, Padera TP. Silence of the lymphs: some anaesthetic regimens inhibit lymphatic pumping. J Physiol. 2019 06; 597(11):2827-2828. PMID: 31032908; PMCID: PMC6995671.
    Citations:    Fields:    
  17. Johnson AR, Granoff MD, Lee BT, Padera TP, Bouta EM, Singhal D. The Impact of Taxane-based Chemotherapy on the Lymphatic System. Ann Plast Surg. 2019 04; 82(4S Suppl 3):S173-S178. PMID: 30855384.
    Citations: 4     Fields:    Translation:Humans
  18. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245. PMID: 30948807.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  19. Liao S, Bouta EM, Morris LM, Jones D, Jain RK, Padera TP. Inducible Nitric Oxide Synthase and CD11b+Gr1+ Cells Impair Lymphatic Contraction of Tumor-Draining Lymphatic Vessels. Lymphat Res Biol. 2019 06; 17(3):294-300. PMID: 30358484.
    Citations: 4     Fields:    Translation:AnimalsCells
  20. Firl DJ, Degn SE, Padera T, Carroll MC. Capturing change in clonal composition amongst single mouse germinal centers. Elife. 2018 08 01; 7. PMID: 30066671.
    Citations: 8     Fields:    Translation:AnimalsCells
  21. Nathanson SD, Krag D, Kuerer HM, Newman LA, Brown M, Kerjaschki D, Pereira ER, Padera TP. Breast cancer metastasis through the lympho-vascular system. Clin Exp Metastasis. 2018 08; 35(5-6):443-454. PMID: 29796854.
    Citations: 16     Fields:    Translation:Humans
  22. Bourquard A, Pablo-Trinidad A, Butterworth I, Sánchez-Ferro Á, Cerrato C, Humala K, Fabra Urdiola M, Del Rio C, Valles B, Tucker-Schwartz JM, Lee ES, Vakoc BJ, Padera TP, Ledesma-Carbayo MJ, Chen YB, Hochberg EP, Gray ML, Castro-González C. Non-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculation. Sci Rep. 2018 03 28; 8(1):5301. PMID: 29593221.
    Citations: 10     Fields:    Translation:HumansCells
  23. Pereira ER, Kedrin D, Seano G, Gautier O, Meijer EFJ, Jones D, Chin SM, Kitahara S, Bouta EM, Chang J, Beech E, Jeong HS, Carroll MC, Taghian AG, Padera TP. Lymph node metastases can invade local blood vessels, exit the node, and colonize distant organs in mice. Science. 2018 03 23; 359(6382):1403-1407. PMID: 29567713; PMCID: PMC6002772.
    Citations: 161     Fields:    Translation:AnimalsCells
  24. Jones D, Pereira ER, Padera TP. Growth and Immune Evasion of Lymph Node Metastasis. Front Oncol. 2018; 8:36. PMID: 29527513; PMCID: PMC5829610.
    Citations: 45     
  25. Bouta EM, Blatter C, Ruggieri TA, Meijer EF, Munn LL, Vakoc BJ, Padera TP. Lymphatic function measurements influenced by contrast agent volume and body position. JCI Insight. 2018 01 25; 3(2). PMID: 29367467.
    Citations: 2     Fields:    Translation:Animals
  26. Jones D, Meijer EFJ, Blatter C, Liao S, Pereira ER, Bouta EM, Jung K, Chin SM, Huang P, Munn LL, Vakoc BJ, Otto M, Padera TP. Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction. Sci Transl Med. 2018 01 17; 10(424). PMID: 29343625.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  27. Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10455-10460. PMID: 28900008.
    Citations: 44     Fields:    Translation:AnimalsCells
  28. Meijer EFJ, Blatter C, Chen IX, Bouta E, Jones D, Pereira ER, Jung K, Vakoc BJ, Baish JW, Padera TP. Lymph node effective vascular permeability and chemotherapy uptake. Microcirculation. 2017 08; 24(6). PMID: 28510992.
    Citations: 8     Fields:    Translation:Animals
  29. Lippok N, Villiger M, Albanese A, Meijer EFJ, Chung K, Padera TP, Bhatia SN, Bouma BE. Depolarization signatures map gold nanorods within biological tissue. Nat Photonics. 2017; 11:583-588. PMID: 29201136; PMCID: PMC5703429.
    Citations: 15     
  30. Blatter C, Meijer EFJ, Padera TP, Vakoc BJ. Simultaneous measurements of lymphatic vessel contraction, flow and valve dynamics in multiple lymphangions using optical coherence tomography. J Biophotonics. 2018 08; 11(8):e201700017. PMID: 28700145; PMCID: PMC5766440.
    Citations: 4     Fields:    Translation:Animals
  31. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. J Clin Invest. 2017 Aug 01; 127(8):3039-3051. PMID: 28691930; PMCID: PMC5531423.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  32. Meijer EFJ, Jeong HS, Pereira ER, Ruggieri TA, Blatter C, Vakoc BJ, Padera TP. Murine chronic lymph node window for longitudinal intravital lymph node imaging. Nat Protoc. 2017 Aug; 12(8):1513-1520. PMID: 28683064.
    Citations: 14     Fields:    Translation:Animals
  33. Baish JW, Kunert C, Padera TP, Munn LL. Synchronization and Random Triggering of Lymphatic Vessel Contractions. PLoS Comput Biol. 2016 12; 12(12):e1005231. PMID: 27935958.
    Citations: 13     Fields:    Translation:Animals
  34. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1. PMID: 28966873.
    Citations: 109     Fields:    
  35. Blatter C, Meijer EF, Nam AS, Jones D, Bouma BE, Padera TP, Vakoc BJ. In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. Sci Rep. 2016 07 05; 6:29035. PMID: 27377852.
    Citations: 23     Fields:    Translation:Animals
  36. Padera TP, Meijer EF, Munn LL. The Lymphatic System in Disease Processes and Cancer Progression. Annu Rev Biomed Eng. 2016 07 11; 18:125-58. PMID: 26863922.
    Citations: 61     Fields:    Translation:HumansAnimals
  37. Meijer EF, Baish JW, Padera TP, Fukumura D. Measuring Vascular Permeability In Vivo. Methods Mol Biol. 2016; 1458:71-85. PMID: 27581015; PMCID: PMC5435480.
    Citations: 6     Fields:    Translation:HumansAnimals
  38. Kunert C, Baish JW, Liao S, Padera TP, Munn LL. Reply to Davis: Nitric oxide regulates lymphatic contractions. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):E106. PMID: 26719425; PMCID: PMC4720299.
    Citations: 4     Fields:    Translation:Humans
  39. Kunert C, Baish JW, Liao S, Padera TP, Munn LL. Mechanobiological oscillators control lymph flow. Proc Natl Acad Sci U S A. 2015 Sep 01; 112(35):10938-43. PMID: 26283382; PMCID: PMC4568261.
    Citations: 33     Fields:    Translation:HumansCells
  40. Jeong HS, Jones D, Liao S, Wattson DA, Cui CH, Duda DG, Willett CG, Jain RK, Padera TP. Investigation of the Lack of Angiogenesis in the Formation of Lymph Node Metastases. J Natl Cancer Inst. 2015 Sep; 107(9). PMID: 26063793; PMCID: PMC4651102.
    Citations: 61     Fields:    Translation:HumansAnimals
  41. Kesler CT, Pereira ER, Cui CH, Nelson GM, Masuck DJ, Baish JW, Padera TP. Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation. FASEB J. 2015 Sep; 29(9):3668-77. PMID: 25977256.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Ladra MM, Mandeville HC, Niemierko A, Padera TP, Friedmann AM, MacDonald SM, Ebb D, Chen YL, Tarbell NJ, Yock TI. Local failure in parameningeal rhabdomyosarcoma correlates with poor response to induction chemotherapy. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):358-67. PMID: 25864172; PMCID: PMC5479480.
    Citations: 3     Fields:    Translation:Humans
  43. Cho JK, Hyun SH, Choi N, Kim MJ, Padera TP, Choi JY, Jeong HS. Significance of lymph node metastasis in cancer dissemination of head and neck cancer. Transl Oncol. 2015 Apr; 8(2):119-25. PMID: 25926078; PMCID: PMC4415144.
    Citations: 13     
  44. Padera TP. Editorial: rapid growth in the field of lymphatic biology. Semin Cell Dev Biol. 2015 Feb; 38:53-4. PMID: 25868083.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Pereira ER, Jones D, Jung K, Padera TP. The lymph node microenvironment and its role in the progression of metastatic cancer. Semin Cell Dev Biol. 2015 Feb; 38:98-105. PMID: 25620792; PMCID: PMC4397158.
    Citations: 66     Fields:    Translation:HumansAnimals
  46. Kuo AH, Ancukiewicz M, Kozak KR, Yock TI, Padera TP. Cardiac and inflammatory biomarkers do not correlate with volume of heart or lung receiving radiation. Radiat Oncol. 2015 Jan 09; 10:5. PMID: 25573181.
    Citations: 10     Fields:    Translation:Humans
  47. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5. PMID: 25026209.
    Citations: 82     Fields:    Translation:Animals
  48. Munn LL, Padera TP. Imaging the lymphatic system. Microvasc Res. 2014 Nov; 96:55-63. PMID: 24956510.
    Citations: 31     Fields:    Translation:HumansAnimals
  49. Liao S, Jones D, Cheng G, Padera TP. Method for the quantitative measurement of collecting lymphatic vessel contraction in mice. J Biol Methods. 2014; 1(2). PMID: 25512945; PMCID: PMC4264607.
    Citations: 9     
  50. Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP. Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Angiogenesis. 2014 Apr; 17(2):419-27. PMID: 24201897.
    Citations: 8     Fields:    Translation:HumansCells
  51. Hagendoorn J, Yock TI, Borel Rinkes IH, Padera TP, Ebb DH. Novel molecular pathways in Gorham disease: implications for treatment. Pediatr Blood Cancer. 2014 Mar; 61(3):401-6. PMID: 24214028.
    Citations: 12     Fields:    Translation:Humans
  52. Liao S, Padera TP. Lymphatic function and immune regulation in health and disease. Lymphat Res Biol. 2013 Sep; 11(3):136-43. PMID: 24024577.
    Citations: 29     Fields:    Translation:HumansAnimals
  53. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst. 2013 Aug 21; 105(16):1188-201. PMID: 23899555.
    Citations: 55     Fields:    Translation:AnimalsCells
  54. Kesler CT, Liao S, Munn LL, Padera TP. Lymphatic vessels in health and disease. Wiley Interdiscip Rev Syst Biol Med. 2013 Jan-Feb; 5(1):111-24. PMID: 23209022.
    Citations: 35     Fields:    Translation:HumansAnimals
  55. Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK. Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 2012; 1(1). PMID: 24353926.
    Citations: 20     
  56. Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9. PMID: 22065738; PMCID: PMC3219138.
    Citations: 136     Fields:    Translation:AnimalsCells
  57. Liao S, Padera TP, Jain RK. Notch leads lymphatics and links them to blood vessels. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1682-3. PMID: 20720193.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Mounzer RH, Svendsen OS, Baluk P, Bergman CM, Padera TP, Wiig H, Jain RK, McDonald DM, Ruddle NH. Lymphotoxin-alpha contributes to lymphangiogenesis. Blood. 2010 Sep 23; 116(12):2173-82. PMID: 20566898; PMCID: PMC2951858.
    Citations: 38     Fields:    Translation:AnimalsCellsPHPublic Health
  59. Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009 Oct; 15(10):1219-23. PMID: 19749772.
    Citations: 308     Fields:    Translation:HumansAnimals
  60. Plotkin SR, Stemmer-Rachamimov AO, Barker FG, Halpin C, Padera TP, Tyrrell A, Sorensen AG, Jain RK, di Tomaso E. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med. 2009 Jul 23; 361(4):358-67. PMID: 19587327; PMCID: PMC4816642.
    Citations: 160     Fields:    Translation:Humans
  61. Chauhan VP, Lanning RM, Diop-Frimpong B, Mok W, Brown EB, Padera TP, Boucher Y, Jain RK. Multiscale measurements distinguish cellular and interstitial hindrances to diffusion in vivo. Biophys J. 2009 Jul 08; 97(1):330-6. PMID: 19580771.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  62. Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK. Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol. 2009 May; 219(2):430-7. PMID: 19170073.
    Citations: 20     Fields:    Translation:AnimalsCells
  63. Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009 Apr 01; 69(7):2801-8. PMID: 19318557.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  64. Perentes JY, McKee TD, Ley CD, Mathiew H, Dawson M, Padera TP, Munn LL, Jain RK, Boucher Y. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5. PMID: 19151720.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  65. Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol Cancer Ther. 2008 Aug; 7(8):2272-9. PMID: 18687659; PMCID: PMC2664998.
    Citations: 50     Fields:    Translation:AnimalsCells
  66. Padera TP, Jain RK. VEGFR3: a new target for antiangiogenesis therapy? Dev Cell. 2008 Aug; 15(2):178-9. PMID: 18694556.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  67. Nelson GM, Padera TP, Garkavtsev I, Shioda T, Jain RK. Differential gene expression of primary cultured lymphatic and blood vascular endothelial cells. Neoplasia. 2007 Dec; 9(12):1038-45. PMID: 18084611.
    Citations: 22     Fields:    Translation:HumansCells
  68. Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK. Anti-VEGFR-3 therapy and lymph node metastasis [corrected]. Cancer Res. 2007 May 15; 67(10):5055; author reply 5056. PMID: 17510438.
    Citations:    Fields:    Translation:Animals
  69. Hagendoorn J, Padera TP, Yock TI, Nielsen GP, di Tomaso E, Duda DG, Delaney TF, Gaissert HA, Pearce J, Rosenberg AE, Jain RK, Ebb DH. Platelet-derived growth factor receptor-beta in Gorham's disease. Nat Clin Pract Oncol. 2006 Dec; 3(12):693-7. PMID: 17139320.
    Citations: 22     Fields:    Translation:Humans
  70. Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res. 2006 Aug 15; 66(16):8065-75. PMID: 16912183.
    Citations: 143     Fields:    Translation:AnimalsCells
  71. Hoon DS, Kitago M, Kim J, Mori T, Piris A, Szyfelbein K, Mihm MC, Nathanson SD, Padera TP, Chambers AF, Vantyghem SA, MacDonald IC, Shivers SC, Alsarraj M, Reintgen DS, Passlick B, Sienel W, Pantel K. Molecular mechanisms of metastasis. Cancer Metastasis Rev. 2006 Jun; 25(2):203-20. PMID: 16770533.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  72. Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 01; 66(7):3360-4. PMID: 16585153.
    Citations: 61     Fields:    Translation:AnimalsCells
  73. Hagendoorn J, Padera TP, Fukumura D, Jain RK. Molecular regulation of microlymphatic formation and function: role of nitric oxide. Trends Cardiovasc Med. 2005 Jul; 15(5):169-73. PMID: 16165013.
    Citations: 6     Fields:    Translation:HumansAnimals
  74. Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res. 2004 Jul 01; 64(13):4400-4. PMID: 15231646.
    Citations: 52     Fields:    Translation:Animals
  75. Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res. 2004 Jul 23; 95(2):204-9. PMID: 15192027.
    Citations: 49     Fields:    Translation:Animals
  76. Padera TP, Stoll BR, Tooredman JB, Capen D, di Tomaso E, Jain RK. Pathology: cancer cells compress intratumour vessels. Nature. 2004 Feb 19; 427(6976):695. PMID: 14973470.
    Citations: 272     Fields:    Translation:HumansAnimals
  77. Padera TP, Boucher Y, Jain RK. Correspondence re: S. Maula et al., intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinoma of the head and neck. Cancer Res., 63: 1920-1926, 2003. Cancer Res. 2003 Dec 01; 63(23):8555-6; author reply 8558. PMID: 14679026.
    Citations: 2     Fields:    Translation:Humans
  78. Jain RK, Padera TP. Development. Lymphatics make the break. Science. 2003 Jan 10; 299(5604):209-10. PMID: 12522236.
    Citations: 7     Fields:    Translation:AnimalsCells
  79. Jain RK, Padera TP. Prevention and treatment of lymphatic metastasis by antilymphangiogenic therapy. J Natl Cancer Inst. 2002 Jun 05; 94(11):785-7. PMID: 12048260.
    Citations: 7     Fields:    Translation:HumansAnimals
  80. Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, Choi NC, Mathisen D, Wain J, Mark EJ, Munn LL, Jain RK. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6. PMID: 11976409.
    Citations: 281     Fields:    Translation:HumansAnimalsCells
  81. Padera TP, Stoll BR, So PT, Jain RK. Conventional and high-speed intravital multiphoton laser scanning microscopy of microvasculature, lymphatics, and leukocyte-endothelial interactions. Mol Imaging. 2002 Jan-Mar; 1(1):9-15. PMID: 12920856.
    Citations: 32     Fields:    Translation:AnimalsCells
  82. Mouta Carreira C, Nasser SM, di Tomaso E, Padera TP, Boucher Y, Tomarev SI, Jain RK. LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis. Cancer Res. 2001 Nov 15; 61(22):8079-84. PMID: 11719431.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  83. Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res. 2001 Mar 15; 61(6):2404-8. PMID: 11289105.
    Citations: 25     Fields:    Translation:AnimalsCells
  84. Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res. 2000 Aug 15; 60(16):4556-60. PMID: 10969807.
    Citations: 24     Fields:    Translation:Animals
  85. Ramanujan S, Koenig GC, Padera TP, Stoll BR, Jain RK. Local imbalance of proangiogenic and antiangiogenic factors: a potential mechanism of focal necrosis and dormancy in tumors. Cancer Res. 2000 Mar 01; 60(5):1442-8. PMID: 10728711.
    Citations: 21     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.