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Robert Neil Husson, M.D.

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Overview
My laboratory is interested in the pathogenesis of Mycobacterium tuberculosis infection. Our research has focused on the mechanisms by which the bacterium adapts to its environment. Our investigations have centered on analysis of transcription regulation by alternative sigma factors of M. tuberculosis, and characterization of signal transduction in this organism mediated by serine/threonine protein kinases.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI130407 (HUSSON, ROBERT N) Jan 23, 2017 - Dec 31, 2018
    NIH/NIAID
    Protein labeling with engineered kinases to identify substrates of M. tuberculosis PknA and PknB
    Role: Principal Investigator
  2. R03AI113281 (HUSSON, ROBERT N) Jul 1, 2014 - Jun 30, 2016
    NIH/NIAID
    Development of a CRISPR interference system for mycobacteria
    Role: Principal Investigator
  3. R21AI097881 (HUSSON, ROBERT N) Jul 1, 2012 - Jun 30, 2014
    NIH/NIAID
    Stress-potentiated screening to identify novel inhibitors of M. tuberculosis
    Role: Principal Investigator
  4. R01AI099204 (HUSSON, ROBERT N) Apr 16, 2012 - Mar 31, 2017
    NIH/NIAID
    Chemical Inhibitors to Define an Essential M. Tuberculosis Signaling Network
    Role: Principal Investigator
  5. R21AI082000 (HUSSON, ROBERT N) May 22, 2009 - Apr 30, 2012
    NIH/NIAID
    Proteome-wide screen for M. tuberculosis antigens
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Carette X, Platig J, Young DC, Helmel M, Young AT, Wang Z, Potluri LP, Moody CS, Zeng J, Prisic S, Paulson JN, Muntel J, Madduri AVR, Velarde J, Mayfield JA, Locher C, Wang T, Quackenbush J, Rhee KY, Moody DB, Steen H, Husson RN. Multisystem Analysis of Mycobacterium tuberculosis Reveals Kinase-Dependent Remodeling of the Pathogen-Environment Interface. MBio. 2018 03 06; 9(2). PMID: 29511081.
    Citations:    Fields:    Translation:Cells
  2. Wang Q, Marchetti R, Prisic S, Ishii K, Arai Y, Ohta I, Inuki S, Uchiyama S, Silipo A, Molinaro A, Husson RN, Fukase K, Fujimoto Y. A Comprehensive Study of the Interaction between Peptidoglycan Fragments and the Extracellular Domain of Mycobacterium tuberculosis Ser/Thr Kinase PknB. Chembiochem. 2017 11 02; 18(21):2094-2098. PMID: 28851116.
    Citations:    Fields:    Translation:Cells
  3. Singh AK, Carette X, Potluri LP, Sharp JD, Xu R, Prisic S, Husson RN. Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system. Nucleic Acids Res. 2016 Oct 14; 44(18):e143. PMID: 27407107.
    Citations: 11     Fields:    Translation:Cells
  4. Sharp JD, Singh AK, Park ST, Lyubetskaya A, Peterson MW, Gomes AL, Potluri LP, Raman S, Galagan JE, Husson RN. Comprehensive Definition of the SigH Regulon of Mycobacterium tuberculosis Reveals Transcriptional Control of Diverse Stress Responses. PLoS One. 2016; 11(3):e0152145. PMID: 27003599.
    Citations: 3     Fields:    Translation:Cells
  5. Schifano JM, Cruz JW, Vvedenskaya IO, Edifor R, Ouyang M, Husson RN, Nickels BE, Woychik NA. tRNA is a new target for cleavage by a MazF toxin. Nucleic Acids Res. 2016 Feb 18; 44(3):1256-70. PMID: 26740583.
    Citations: 16     Fields:    Translation:Cells
  6. Cruz JW, Sharp JD, Hoffer ED, Maehigashi T, Vvedenskaya IO, Konkimalla A, Husson RN, Nickels BE, Dunham CM, Woychik NA. Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase. Nat Commun. 2015 Jul 09; 6:7480. PMID: 26158745; PMCID: PMC4620994.
    Citations: 17     Fields:    Translation:Cells
  7. Prisic S, Hwang H, Dow A, Barnaby O, Pan TS, Lonzanida JA, Chazin WJ, Steen H, Husson RN. Zinc regulates a switch between primary and alternative S18 ribosomal proteins in Mycobacterium tuberculosis. Mol Microbiol. 2015 Jul; 97(2):263-80. PMID: 25858183; PMCID: PMC4548965.
    Citations: 9     Fields:    Translation:Cells
  8. Prisic S, Husson RN. Mycobacterium tuberculosis Serine/Threonine Protein Kinases. Microbiol Spectr. 2014 Oct; 2(5). PMID: 25429354.
    Citations: 12     Fields:    Translation:CellsPHPublic Health
  9. Anandan T, Han J, Baun H, Nyayapathy S, Brown JT, Dial RL, Moltalvo JA, Kim MS, Yang SH, Ronning DR, Husson RN, Suh J, Kang CM. Phosphorylation regulates mycobacterial proteasome. J Microbiol. 2014 Sep; 52(9):743-54. PMID: 25224505.
    Citations: 6     Fields:    Translation:Cells
  10. Mir M, Prisic S, Kang CM, Lun S, Guo H, Murry JP, Rubin EJ, Husson RN. Mycobacterial gene cuvA is required for optimal nutrient utilization and virulence. Infect Immun. 2014 Oct; 82(10):4104-17. PMID: 25047842; PMCID: PMC4187881.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Schifano JM, Edifor R, Sharp JD, Ouyang M, Konkimalla A, Husson RN, Woychik NA. Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rRNA at the ribosomal A site. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8501-6. PMID: 23650345; PMCID: PMC3666664.
    Citations: 36     Fields:    Translation:Cells
  12. Chou MF, Prisic S, Lubner JM, Church GM, Husson RN, Schwartz D. Using bacteria to determine protein kinase specificity and predict target substrates. PLoS One. 2012; 7(12):e52747. PMID: 23300758; PMCID: PMC3530509.
    Citations: 10     Fields:    Translation:HumansCells
  13. Sharp JD, Cruz JW, Raman S, Inouye M, Husson RN, Woychik NA. Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin. J Biol Chem. 2012 Apr 13; 287(16):12835-47. PMID: 22354968; PMCID: PMC3339977.
    Citations: 22     Fields:    Translation:Cells
  14. Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012; 7(2):e31307. PMID: 22359585.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Peters JM, Madhavan VL, Kazacos KR, Husson RN, Dangoudoubiyam S, Soul JS. Good outcome with early empiric treatment of neural larva migrans due to Baylisascaris procyonis. Pediatrics. 2012 Mar; 129(3):e806-11. PMID: 22311989.
    Citations: 4     Fields:    Translation:HumansAnimals
  16. Mir M, Asong J, Li X, Cardot J, Boons GJ, Husson RN. The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog. 2011 Jul; 7(7):e1002182. PMID: 21829358; PMCID: PMC3145798.
    Citations: 38     Fields:    Translation:Cells
  17. Kang CM, Jahng WJ, Husson RN, Lee SH. A modified immunoblot method to identify substrates of protein kinases. J Microbiol. 2011 Jun; 49(3):499-501. PMID: 21717339.
    Citations:    Fields:    Translation:Cells
  18. Prisic S, Dankwa S, Schwartz D, Chou MF, Locasale JW, Kang CM, Bemis G, Church GM, Steen H, Husson RN. Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7521-6. PMID: 20368441; PMCID: PMC2867705.
    Citations: 71     Fields:    Translation:Cells
  19. Pandey AK, Raman S, Proff R, Joshi S, Kang CM, Rubin EJ, Husson RN, Sassetti CM. Nitrile-inducible gene expression in mycobacteria. Tuberculosis (Edinb). 2009 Jan; 89(1):12-6. PMID: 18801704; PMCID: PMC2845969.
    Citations: 27     Fields:    Translation:AnimalsCells
  20. Park ST, Kang CM, Husson RN. Regulation of the SigH stress response regulon by an essential protein kinase in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13105-10. PMID: 18728196; PMCID: PMC2529121.
    Citations: 41     Fields:    Translation:Cells
  21. Zhu L, Phadtare S, Nariya H, Ouyang M, Husson RN, Inouye M. The mRNA interferases, MazF-mt3 and MazF-mt7 from Mycobacterium tuberculosis target unique pentad sequences in single-stranded RNA. Mol Microbiol. 2008 Aug; 69(3):559-69. PMID: 18485066.
    Citations:    
  22. Kang CM, Nyayapathy S, Lee JY, Suh JW, Husson RN. Wag31, a homologue of the cell division protein DivIVA, regulates growth, morphology and polar cell wall synthesis in mycobacteria. Microbiology. 2008 Mar; 154(Pt 3):725-35. PMID: 18310019.
    Citations: 76     Fields:    Translation:Cells
  23. Song T, Song SE, Raman S, Anaya M, Husson RN. Critical role of a single position in the -35 element for promoter recognition by Mycobacterium tuberculosis SigE and SigH. J Bacteriol. 2008 Mar; 190(6):2227-30. PMID: 18192397; PMCID: PMC2258898.
    Citations: 15     Fields:    Translation:Cells
  24. Williams DL, Pittman TL, Deshotel M, Oby-Robinson S, Smith I, Husson R. Molecular basis of the defective heat stress response in Mycobacterium leprae. J Bacteriol. 2007 Dec; 189(24):8818-27. PMID: 17933896; PMCID: PMC2168617.
    Citations: 7     Fields:    Translation:Cells
  25. Husson RN. Leaving on the lights: host-specific derepression of Mycobacterium tuberculosis gene expression by anti-sigma factor gene mutations. Mol Microbiol. 2006 Dec; 62(5):1217-9. PMID: 17064363.
    Citations: 1     Fields:    Translation:HumansCells
  26. Raman S, Puyang X, Cheng TY, Young DC, Moody DB, Husson RN. Mycobacterium tuberculosis SigM positively regulates Esx secreted protein and nonribosomal peptide synthetase genes and down regulates virulence-associated surface lipid synthesis. J Bacteriol. 2006 Dec; 188(24):8460-8. PMID: 17028284; PMCID: PMC1698216.
    Citations: 21     Fields:    Translation:HumansCells
  27. Hahn MY, Raman S, Anaya M, Husson RN. The Mycobacterium tuberculosis extracytoplasmic-function sigma factor SigL regulates polyketide synthases and secreted or membrane proteins and is required for virulence. J Bacteriol. 2005 Oct; 187(20):7062-71. PMID: 16199577; PMCID: PMC1251616.
    Citations: 40     Fields:    Translation:AnimalsCells
  28. Kang CM, Abbott DW, Park ST, Dascher CC, Cantley LC, Husson RN. The Mycobacterium tuberculosis serine/threonine kinases PknA and PknB: substrate identification and regulation of cell shape. Genes Dev. 2005 Jul 15; 19(14):1692-704. PMID: 15985609; PMCID: PMC1176007.
    Citations: 115     Fields:    Translation:Cells
  29. Kovacs A, Cowles MK, Britto P, Capparelli E, Fowler MG, Moye J, McIntosh K, Rathore MH, Pitt J, Husson RN. Pharmacokinetics of didanosine and drug resistance mutations in infants exposed to zidovudine during gestation or postnatally and treated with didanosine or zidovudine in the first three months of life. Pediatr Infect Dis J. 2005 Jun; 24(6):503-9. PMID: 15933559.
    Citations: 2     Fields:    Translation:HumansCellsCTClinical Trials
  30. Raman S, Hazra R, Dascher CC, Husson RN. Transcription regulation by the Mycobacterium tuberculosis alternative sigma factor SigD and its role in virulence. J Bacteriol. 2004 Oct; 186(19):6605-16. PMID: 15375142; PMCID: PMC516600.
    Citations: 40     Fields:    Translation:AnimalsCells
  31. Lerman SJ, Bernardo J, Daly JS, Husson R. Tuberculosis prevention in college students. J Am Coll Health. 2004 Sep-Oct; 53(2):53-8. PMID: 15495880.
    Citations:    Fields:    Translation:HumansPHPublic Health
  32. Malley R, Stack AM, Husson RN, Thompson CM, Fleisher GR, Saladino RA. Development of a model of focal pneumococcal pneumonia in young rats. J Immune Based Ther Vaccines. 2004 Jan 23; 2(1):2. PMID: 14741053.
    Citations: 2     
  33. Song T, Dove SL, Lee KH, Husson RN. RshA, an anti-sigma factor that regulates the activity of the mycobacterial stress response sigma factor SigH. Mol Microbiol. 2003 Nov; 50(3):949-59. PMID: 14617153.
    Citations: 45     Fields:    Translation:Cells
  34. Raman S, Song T, Puyang X, Bardarov S, Jacobs WR, Husson RN. The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. J Bacteriol. 2001 Oct; 183(20):6119-25. PMID: 11567012; PMCID: PMC99691.
    Citations: 86     Fields:    Translation:Cells
  35. Hazra R, Floyd MM, Sloutsky A, Husson RN. Novel mycobacterium related to Mycobacterium triplex as a cause of cervical lymphadenitis. J Clin Microbiol. 2001 Apr; 39(4):1227-30. PMID: 11283032; PMCID: PMC87915.
    Citations: 5     Fields:    Translation:HumansCells
  36. Hazra R, Lee SH, Maslow JN, Husson RN. Related strains of Mycobacterium avium cause disease in children with AIDS and in children with lymphadenitis. J Infect Dis. 2000 Apr; 181(4):1298-303. PMID: 10753729.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  37. Robson CD, Hazra R, Barnes PD, Robertson RL, Jones D, Husson RN. Nontuberculous mycobacterial infection of the head and neck in immunocompetent children: CT and MR findings. AJNR Am J Neuroradiol. 1999 Nov-Dec; 20(10):1829-35. PMID: 10588104.
    Citations: 13     Fields:    Translation:Humans
  38. DeVincenzo JP, Berning SE, Peloquin CA, Husson RN. Multidrug-resistant tuberculosis meningitis: clinical problems and concentrations of second-line antituberculous medications. Ann Pharmacother. 1999 Nov; 33(11):1184-8. PMID: 10573317.
    Citations: 9     Fields:    Translation:HumansCells
  39. Fernandes ND, Wu QL, Kong D, Puyang X, Garg S, Husson RN. A mycobacterial extracytoplasmic sigma factor involved in survival following heat shock and oxidative stress. J Bacteriol. 1999 Jul; 181(14):4266-74. PMID: 10400584; PMCID: PMC93928.
    Citations: 36     Fields:    Translation:Cells
  40. Rubin EJ, Akerley BJ, Novik VN, Lampe DJ, Husson RN, Mekalanos JJ. In vivo transposition of mariner-based elements in enteric bacteria and mycobacteria. Proc Natl Acad Sci U S A. 1999 Feb 16; 96(4):1645-50. PMID: 9990078; PMCID: PMC15546.
    Citations: 151     Fields:    Translation:Cells
  41. Hazra R, Robson CD, Perez-Atayde AR, Husson RN. Lymphadenitis due to nontuberculous mycobacteria in children: presentation and response to therapy. Clin Infect Dis. 1999 Jan; 28(1):123-9. PMID: 10028082.
    Citations: 26     Fields:    Translation:HumansCells
  42. Chong CY, Husson RN. Lack of acceptance of guidelines for prevention of disseminated Mycobacterium avium complex infection in infants and children infected with human immunodeficiency virus. Pediatr Infect Dis J. 1998 Dec; 17(12):1131-5. PMID: 9877361.
    Citations:    Fields:    Translation:HumansPHPublic Health
  43. Husson RN. Homologous recombination in Mycobacterium smegmatis. Screening methods for detection of gene replacement. Methods Mol Biol. 1998; 101:199-206. PMID: 9921479.
    Citations:    Fields:    Translation:Cells
  44. Wu QL, Kong D, Lam K, Husson RN. A mycobacterial extracytoplasmic function sigma factor involved in survival following stress. J Bacteriol. 1997 May; 179(9):2922-9. PMID: 9139909; PMCID: PMC179055.
    Citations: 42     Fields:    Translation:Cells
  45. Husson RN, Lan Y, Kojima E, Venzon D, Mitsuya H, McIntosh K. Vertical transmission of human immunodeficiency virus type 1: autologous neutralizing antibody, virus load, and virus phenotype. J Pediatr. 1995 Jun; 126(6):865-71. PMID: 7776085.
    Citations: 10     Fields:    Translation:HumansCells
  46. Mueller BU, Butler KM, Stocker VL, Balis FM, Brouwers P, Jarosinski P, Husson RN, Lewis LL, Venzon D, Pizzo PA. Clinical and pharmacokinetic evaluation of long-term therapy with didanosine in children with HIV infection. Pediatrics. 1994 Nov; 94(5):724-31. PMID: 7936903.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  47. Mueller BU, Pizzo PA, Farley M, Husson RN, Goldsmith J, Kovacs A, Woods L, Ono J, Church JA, Brouwers P, et al. Pharmacokinetic evaluation of the combination of zidovudine and didanosine in children with human immunodeficiency virus infection. J Pediatr. 1994 Jul; 125(1):142-6. PMID: 8021765.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  48. Husson RN, Ross LA, Sandelli S, Inderlied CB, Venzon D, Lewis LL, Woods L, Conville PS, Witebsky FG, Pizzo PA. Orally administered clarithromycin for the treatment of systemic Mycobacterium avium complex infection in children with acquired immunodeficiency syndrome. J Pediatr. 1994 May; 124(5 Pt 1):807-14. PMID: 8176574.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  49. Husson RN, Mueller BU, Farley M, Woods L, Kovacs A, Goldsmith JC, Ono J, Lewis LL, Balis FM, Brouwers P, et al. Zidovudine and didanosine combination therapy in children with human immunodeficiency virus infection. Pediatrics. 1994 Feb; 93(2):316-22. PMID: 7907174.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  50. Aldovini A, Husson RN, Young RA. The uraA locus and homologous recombination in Mycobacterium bovis BCG. J Bacteriol. 1993 Nov; 175(22):7282-9. PMID: 8226675; PMCID: PMC206871.
    Citations: 25     Fields:    Translation:Cells
  51. Husson RN, Shirasaka T, Butler KM, Pizzo PA, Mitsuya H. High-level resistance to zidovudine but not to zalcitabine or didanosine in human immunodeficiency virus from children receiving antiretroviral therapy. J Pediatr. 1993 Jul; 123(1):9-16. PMID: 8391570.
    Citations: 5     Fields:    Translation:HumansCells
  52. Butler KM, Venzon D, Henry N, Husson RN, Mueller BU, Balis FM, Jacobsen F, Lewis LL, Pizzo PA. Pancreatitis in human immunodeficiency virus-infected children receiving dideoxyinosine. Pediatrics. 1993 Apr; 91(4):747-51. PMID: 7681940.
    Citations: 13     Fields:    Translation:Humans
  53. Robert-Guroff M, Roilides E, Muldoon R, Venzon D, Husson R, Marshall D, Gallo RC, Pizzo PA. Human immunodeficiency virus (HIV) type 1 strain MN neutralizing antibody in HIV-infected children: correlation with clinical status and prognostic value. J Infect Dis. 1993 Mar; 167(3):538-46. PMID: 7680059.
    Citations: 4     Fields:    Translation:HumansCells
  54. Shirasaka T, Yarchoan R, O'Brien MC, Husson RN, Anderson BD, Kojima E, Shimada T, Broder S, Mitsuya H. Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):562-6. PMID: 8380641; PMCID: PMC45703.
    Citations: 33     Fields:    Translation:HumansCells
  55. Husson RN, Saini R, Lewis LL, Butler KM, Patronas N, Pizzo PA. Cerebral artery aneurysms in children infected with human immunodeficiency virus. J Pediatr. 1992 Dec; 121(6):927-30. PMID: 1447659.
    Citations: 10     Fields:    Translation:HumansCells
  56. Lewis LL, Butler KM, Husson RN, Mueller BU, Fowler CL, Steinberg SM, Pizzo PA. Defining the population of human immunodeficiency virus-infected children at risk for Mycobacterium avium-intracellulare infection. J Pediatr. 1992 Nov; 121(5 Pt 1):677-83. PMID: 1432413.
    Citations: 3     Fields:    Translation:HumansCells
  57. Mueller BU, Jacobsen F, Butler KM, Husson RN, Lewis LL, Pizzo PA. Combination treatment with azidothymidine and granulocyte colony-stimulating factor in children with human immunodeficiency virus infection. J Pediatr. 1992 Nov; 121(5 Pt 1):797-802. PMID: 1279153.
    Citations: 5     Fields:    Translation:HumansCells
  58. Husson RN, Chung Y, Mordenti J, Butler KM, Chen S, Duliege AM, Brouwers P, Jarosinski P, Mueller BU, Ammann A, et al. Phase I study of continuous-infusion soluble CD4 as a single agent and in combination with oral dideoxyinosine therapy in children with symptomatic human immunodeficiency virus infection. J Pediatr. 1992 Oct; 121(4):627-33. PMID: 1357124.
    Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
  59. Mueller BU, Butler KM, Higham MC, Husson RN, Montrella KA, Pizzo PA, Feuerstein IM, Manjunath K. Smooth muscle tumors in children with human immunodeficiency virus infection. Pediatrics. 1992 Sep; 90(3):460-3. PMID: 1518708.
    Citations: 7     Fields:    Translation:Humans
  60. Butler KM, Husson RN, Lewis LL, Mueller BU, Venzon D, Pizzo PA. CD4 status and P24 antigenemia. Are they useful predictors of survival in HIV-infected children receiving antiretroviral therapy? Am J Dis Child. 1992 Aug; 146(8):932-6. PMID: 1353299.
    Citations: 1     Fields:    Translation:HumansCells
  61. Roilides E, Butler KM, Husson RN, Mueller BU, Lewis LL, Pizzo PA. Pseudomonas infections in children with human immunodeficiency virus infection. Pediatr Infect Dis J. 1992 Jul; 11(7):547-53. PMID: 1528645.
    Citations: 11     Fields:    Translation:HumansCells
  62. Husson RN, Pizzo PA. The use of nucleoside analogues in the treatment of HIV-infected children. AIDS Res Hum Retroviruses. 1992 Jun; 8(6):1059-64. PMID: 1323984.
    Citations: 1     Fields:    Translation:Humans
  63. Butler KM, De Smet MD, Husson RN, Mueller B, Manjunath K, Montrella K, Lovato G, Jarosinski P, Nussenblatt RB, Pizzo PA. Treatment of aggressive cytomegalovirus retinitis with ganciclovir in combination with foscarnet in a child infected with human immunodeficiency virus. J Pediatr. 1992 Mar; 120(3):483-6. PMID: 1311378.
    Citations: 9     Fields:    Translation:Humans
  64. Whitcup SM, Butler KM, Caruso R, de Smet MD, Rubin B, Husson RN, Lopez JS, Belfort R, Pizzo PA, Nussenblatt RB. Retinal toxicity in human immunodeficiency virus-infected children treated with 2',3'-dideoxyinosine. Am J Ophthalmol. 1992 Jan 15; 113(1):1-7. PMID: 1728133.
    Citations: 9     Fields:    Translation:HumansCellsCTClinical Trials
  65. Balis FM, Pizzo PA, Butler KM, Hawkins ME, Brouwers P, Husson RN, Jacobsen F, Blaney SM, Gress J, Jarosinski P, et al. Clinical pharmacology of 2',3'-dideoxyinosine in human immunodeficiency virus-infected children. J Infect Dis. 1992 Jan; 165(1):99-104. PMID: 1727902.
    Citations: 28     Fields:    Translation:HumansCellsCTClinical Trials
  66. Mueller BU, Butler KM, Husson RN, Pizzo PA. Pneumocystis carinii pneumonia despite prophylaxis in children with human immunodeficiency virus infection. J Pediatr. 1991 Dec; 119(6):992-4. PMID: 1960625.
    Citations: 2     Fields:    Translation:Humans
  67. Roilides E, Marshall D, Venzon D, Butler K, Husson R, Pizzo PA. Bacterial infections in human immunodeficiency virus type 1-infected children: the impact of central venous catheters and antiretroviral agents. Pediatr Infect Dis J. 1991 Nov; 10(11):813-9. PMID: 1661003.
    Citations: 3     Fields:    Translation:HumansCells
  68. Butler KM, Husson RN, Balis FM, Brouwers P, Eddy J, el-Amin D, Gress J, Hawkins M, Jarosinski P, Moss H, et al. Dideoxyinosine in children with symptomatic human immunodeficiency virus infection. N Engl J Med. 1991 Jan 17; 324(3):137-44. PMID: 1670591.
    Citations: 34     Fields:    Translation:HumansCellsCTClinical Trials
  69. Butler KM, Husson RN, Balis FM. Drug trial benefited HIV children. Nurs Times. 1991 Jan 30-Feb 5; 87(5):10. PMID: 1899723.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  70. Pizzo PA, Butler K, Balis F, Brouwers E, Hawkins M, Eddy J, Einloth M, Falloon J, Husson R, Jarosinski P, et al. Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infection. J Pediatr. 1990 Nov; 117(5):799-808. PMID: 2172501.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  71. Husson RN, Comeau AM, Hoff R. Diagnosis of human immunodeficiency virus infection in infants and children. Pediatrics. 1990 Jul; 86(1):1-10. PMID: 2193299.
    Citations: 13     Fields:    Translation:HumansCells
  72. Husson RN, James BE, Young RA. Gene replacement and expression of foreign DNA in mycobacteria. J Bacteriol. 1990 Feb; 172(2):519-24. PMID: 2153655; PMCID: PMC208472.
    Citations: 51     Fields:    Translation:Cells
  73. Boom WH, Husson RN, Young RA, David JR, Piessens WF. In vivo and in vitro characterization of murine T-cell clones reactive to Mycobacterium tuberculosis. Infect Immun. 1987 Sep; 55(9):2223-9. PMID: 3114149; PMCID: PMC260682.
    Citations: 19     Fields:    Translation:AnimalsCells
  74. Husson RN, Young RA. Genes for the major protein antigens of Mycobacterium tuberculosis: the etiologic agents of tuberculosis and leprosy share an immunodominant antigen. Proc Natl Acad Sci U S A. 1987 Mar; 84(6):1679-83. PMID: 3104901; PMCID: PMC304500.
    Citations: 30     Fields:    Translation:AnimalsCells
  75. Oftung F, Mustafa AS, Husson R, Young RA, Godal T. Human T cell clones recognize two abundant Mycobacterium tuberculosis protein antigens expressed in Escherichia coli. J Immunol. 1987 Feb 01; 138(3):927-31. PMID: 2433335.
    Citations: 39     Fields:    Translation:HumansCells
  76. Orkin SH, Kolodner R, Michelson A, Husson R. Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3558-62. PMID: 6251466; PMCID: PMC349656.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.