Harvard Catalyst Profiles

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Nan Chiang, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chiang N, Libreros S, Norris PC, de la Rosa X, Serhan CN. Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. J Clin Invest. 2019 12 02; 129(12):5294-5311. PMID: 31657786.
  2. Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV. Addendum: Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3?DPA. Chemistry. 2019 11 27; 25(66):15212. PMID: 31774939.
  3. Tungen JE, Gerstmann L, Vik A, De Matteis R, Colas RA, Dalli J, Chiang N, Serhan CN, Kalesse M, Hansen TV. Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3?DPA. Chemistry. 2019 Jan 28; 25(6):1476-1480. PMID: 30511787.
    Citations:    Fields:    
  4. Chiang N, Barnaeva E, Hu X, Marugan J, Southall N, Ferrer M, Serhan CN. Identification of Chemotype Agonists for Human Resolvin D1 Receptor DRV1 with Pro-Resolving Functions. Cell Chem Biol. 2019 02 21; 26(2):244-254.e4. PMID: 30554914.
  5. Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):9252-9257. PMID: 30139917.
    Citations:    Fields:    Translation:AnimalsCells
  6. de la Rosa X, Norris PC, Chiang N, Rodriguez AR, Spur BW, Serhan CN. Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration. Am J Pathol. 2018 04; 188(4):950-966. PMID: 29571326.
    Citations: 2     Fields:    
  7. Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 09; 138(9):2051-2060. PMID: 29559341.
    Citations:    Fields:    
  8. Chiang N, Riley IR, Dalli J, Rodriguez AR, Spur BW, Serhan CN. New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses. FASEB J. 2018 07; 32(7):4043-4052. PMID: 29490167.
    Citations: 1     Fields:    
  9. Winkler JW, Libreros S, De La Rosa X, Sansbury BE, Norris PC, Chiang N, Fichtner D, Keyes GS, Wourms N, Spite M, Serhan CN. Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation. J Leukoc Biol. 2018 Jan 29. PMID: 29377345.
    Citations: 3     Fields:    
  10. Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CN. Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity. Nat Commun. 2018 01 04; 9(1):59. PMID: 29302056.
    Citations: 2     Fields:    Translation:HumansCells
  11. Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA. THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017 Dec; 174 Suppl 1:S1-S16. PMID: 29055037.
    Citations: 37     Fields:    Translation:Humans
  12. Serhan CN, Chiang N, Dalli J. New pro-resolving n-3 mediators bridge resolution of infectious inflammation to tissue regeneration. Mol Aspects Med. 2018 12; 64:1-17. PMID: 28802833.
    Citations: 11     Fields:    
  13. Norris PC, Libreros S, Chiang N, Serhan CN. A cluster of immunoresolvents links coagulation to innate host defense in human blood. Sci Signal. 2017 Aug 01; 10(490). PMID: 28765512.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Chiang N, Serhan CN. Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol Aspects Med. 2017 Dec; 58:114-129. PMID: 28336292.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  15. Chiang N, de la Rosa X, Libreros S, Serhan CN. Novel Resolvin D2 Receptor Axis in Infectious Inflammation. J Immunol. 2017 01 15; 198(2):842-851. PMID: 27994074.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Colas RA, Dalli J, Chiang N, Vlasakov I, Sanger JM, Riley IR, Serhan CN. Identification and Actions of the Maresin 1 Metabolome in Infectious Inflammation. J Immunol. 2016 12 01; 197(11):4444-4452. PMID: 27799313.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  17. Dalli J, Vlasakov I, Riley IR, Rodriguez AR, Spur BW, Petasis NA, Chiang N, Serhan CN. Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages. Proc Natl Acad Sci U S A. 2016 10 25; 113(43):12232-12237. PMID: 27791009.
    Citations: 8     Fields:    Translation:HumansCells
  18. Elajami TK, Colas RA, Dalli J, Chiang N, Serhan CN, Welty FK. Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling. FASEB J. 2016 08; 30(8):2792-801. PMID: 27121596.
    Citations: 21     Fields:    Translation:Humans
  19. Dalli J, Sanger JM, Rodriguez AR, Chiang N, Spur BW, Serhan CN. Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3. PLoS One. 2016; 11(2):e0149319. PMID: 26881986.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  20. Winkler JW, Orr SK, Dalli J, Cheng CY, Sanger JM, Chiang N, Petasis NA, Serhan CN. Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance. Sci Rep. 2016 Jan 08; 6:18972. PMID: 26743932.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  21. Wang CW, Colas RA, Dalli J, Arnardottir HH, Nguyen D, Hasturk H, Chiang N, Van Dyke TE, Serhan CN. Maresin 1 Biosynthesis and Proresolving Anti-infective Functions with Human-Localized Aggressive Periodontitis Leukocytes. Infect Immun. 2015 Dec 14; 84(3):658-65. PMID: 26667839.
    Citations: 9     Fields:    Translation:HumansCells
  22. Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN. The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide. Am J Respir Cell Mol Biol. 2015 Sep; 53(3):314-25. PMID: 25568926.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Dalli J, Chiang N, Serhan CN. Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med. 2015 Sep; 21(9):1071-5. PMID: 26236990.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  24. Chiang N, Dalli J, Colas RA, Serhan CN. Identification of resolvin D2 receptor mediating resolution of infections and organ protection. J Exp Med. 2015 Jul 27; 212(8):1203-17. PMID: 26195725.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  25. Serhan CN, Chiang N, Dalli J. The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution. Semin Immunol. 2015 May; 27(3):200-15. PMID: 25857211.
    Citations: 85     Fields:    Translation:HumansAnimals
  26. Orr SK, Colas RA, Dalli J, Chiang N, Serhan CN. Proresolving actions of a new resolvin D1 analog mimetic qualifies as an immunoresolvent. Am J Physiol Lung Cell Mol Physiol. 2015 May 01; 308(9):L904-11. PMID: 25770181.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  27. Shelnut EL, Nikas SP, Finnegan DF, Chiang N, Serhan CN, Makriyannis A. Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s). Tetrahedron Lett. 2015 Mar 11; 56(11):1411-1415. PMID: 25960577.
    Citations: 1     Fields:    
  28. Finnegan DF, Shelnut EL, Nikas SP, Chiang N, Serhan CN, Makriyannis A. Novel tail and head group prostamide probes. Bioorg Med Chem Lett. 2015 Mar 15; 25(6):1228-31. PMID: 25701254.
    Citations:    Fields:    Translation:HumansAnimalsCells
  29. Serhan CN, Chiang N, Dalli J, Levy BD. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 2014 Oct 30; 7(2):a016311. PMID: 25359497.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  30. Dalli J, Chiang N, Serhan CN. Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):E4753-61. PMID: 25324525.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  31. Shinohara M, Kibi M, Riley IR, Chiang N, Dalli J, Kraft BD, Piantadosi CA, Choi AM, Serhan CN. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15; 307(10):L746-57. PMID: 25217660.
    Citations: 16     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  32. Serhan CN, Dalli J, Colas RA, Winkler JW, Chiang N. Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta. 2015 Apr; 1851(4):397-413. PMID: 25139562.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  33. McCauley LK, Dalli J, Koh AJ, Chiang N, Serhan CN. Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2. J Immunol. 2014 Jul 01; 193(1):26-9. PMID: 24890726.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  34. Colas RA, Shinohara M, Dalli J, Chiang N, Serhan CN. Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol. 2014 Jul 01; 307(1):C39-54. PMID: 24696140.
    Citations: 113     Fields:    Translation:HumansCells
  35. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M. The Concise Guide to PHARMACOLOGY 2013/14: overview. Br J Pharmacol. 2013 Dec; 170(8):1449-58. PMID: 24528237.
    Citations: 111     Fields:    Translation:Humans
  36. Li Y, Dalli J, Chiang N, Baron RM, Quintana C, Serhan CN. Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators. Immunity. 2013 Nov 14; 39(5):885-98. PMID: 24238341.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  37. Zhong C, Wang J, Li B, Xiang H, Ultsch M, Coons M, Wong T, Chiang NY, Clark S, Clark R, Quintana L, Gribling P, Suto E, Barck K, Corpuz R, Yao J, Takkar R, Lee WP, Damico-Beyer LA, Carano RD, Adams C, Kelley RF, Wang W, Ferrara N. Development and preclinical characterization of a humanized antibody targeting CXCL12. Clin Cancer Res. 2013 Aug 15; 19(16):4433-45. PMID: 23812669.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  38. Serhan CN, Chiang N. Resolution phase lipid mediators of inflammation: agonists of resolution. Curr Opin Pharmacol. 2013 Aug; 13(4):632-40. PMID: 23747022.
    Citations: 71     Fields:    Translation:HumansAnimals
  39. Chiang N, Shinohara M, Dalli J, Mirakaj V, Kibi M, Choi AM, Serhan CN. Inhaled carbon monoxide accelerates resolution of inflammation via unique proresolving mediator-heme oxygenase-1 circuits. J Immunol. 2013 Jun 15; 190(12):6378-88. PMID: 23650615.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  40. Li D, Hodges RR, Jiao J, Carozza RB, Shatos MA, Chiang N, Serhan CN, Dartt DA. Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion. Mucosal Immunol. 2013 Nov; 6(6):1119-30. PMID: 23462912.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  41. Dalli J, Winkler JW, Colas RA, Arnardottir H, Cheng CY, Chiang N, Petasis NA, Serhan CN. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents. Chem Biol. 2013 Feb 21; 20(2):188-201. PMID: 23438748.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  42. Gao L, Faibish D, Fredman G, Herrera BS, Chiang N, Serhan CN, Van Dyke TE, Gyurko R. Resolvin E1 and chemokine-like receptor 1 mediate bone preservation. J Immunol. 2013 Jan 15; 190(2):689-94. PMID: 23241890.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  43. Fredman G, Li Y, Dalli J, Chiang N, Serhan CN. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. Sci Rep. 2012; 2:639. PMID: 22957142.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  44. Chiang N, Fredman G, Bäckhed F, Oh SF, Vickery T, Schmidt BA, Serhan CN. Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature. 2012 Apr 25; 484(7395):524-8. PMID: 22538616.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  45. Krishnamoorthy S, Recchiuti A, Chiang N, Fredman G, Serhan CN. Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May; 180(5):2018-27. PMID: 22449948.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  46. Yang R, Chiang N, Oh SF, Serhan CN. Metabolomics-lipidomics of eicosanoids and docosanoids generated by phagocytes. Curr Protoc Immunol. 2011 Nov; Chapter 14:Unit 14.26. PMID: 22048801.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  47. Serhan CN, Krishnamoorthy S, Recchiuti A, Chiang N. Novel anti-inflammatory--pro-resolving mediators and their receptors. Curr Top Med Chem. 2011; 11(6):629-47. PMID: 21261595.
    Citations: 74     Fields:    Translation:HumansAnimals
  48. Recchiuti A, Krishnamoorthy S, Fredman G, Chiang N, Serhan CN. MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits. FASEB J. 2011 Feb; 25(2):544-60. PMID: 20956612.
    Citations: 91     Fields:    Translation:Animals
  49. Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN. Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1660-5. PMID: 20080636.
    Citations: 201     Fields:    Translation:HumansCells
  50. Jin Y, Arita M, Zhang Q, Saban DR, Chauhan SK, Chiang N, Serhan CN, Dana R. Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4743-52. PMID: 19407006.
    Citations: 50     Fields:    Translation:AnimalsCells
  51. Dona M, Fredman G, Schwab JM, Chiang N, Arita M, Goodarzi A, Cheng G, von Andrian UH, Serhan CN. Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood. 2008 Aug 01; 112(3):848-55. PMID: 18480426.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  52. Serhan CN, Chiang N, Van Dyke TE. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 2008 May; 8(5):349-61. PMID: 18437155.
    Citations: 704     Fields:    Translation:HumansAnimalsCells
  53. Chiang N, Schwab JM, Fredman G, Kasuga K, Gelman S, Serhan CN. Anesthetics impact the resolution of inflammation. PLoS One. 2008 Apr 02; 3(4):e1879. PMID: 18382663.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  54. Serhan CN, Chiang N. Endogenous pro-resolving and anti-inflammatory lipid mediators: a new pharmacologic genus. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S200-15. PMID: 17965751.
    Citations: 118     Fields:    Translation:HumansAnimals
  55. Schwab JM, Chiang N, Arita M, Serhan CN. Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature. 2007 Jun 14; 447(7146):869-74. PMID: 17568749.
    Citations: 352     Fields:    Translation:AnimalsCells
  56. Arita M, Ohira T, Sun YP, Elangovan S, Chiang N, Serhan CN. Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol. 2007 Mar 15; 178(6):3912-7. PMID: 17339491.
    Citations: 155     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  57. Chiang N, Serhan CN, Dahlén SE, Drazen JM, Hay DW, Rovati GE, Shimizu T, Yokomizo T, Brink C. The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev. 2006 Sep; 58(3):463-87. PMID: 16968948.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  58. Chiang N, Serhan CN. Cell-cell interaction in the transcellular biosynthesis of novel omega-3-derived lipid mediators. Methods Mol Biol. 2006; 341:227-50. PMID: 16799203.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  59. Chiang N, Serhan CN. New mechanism for an old drug: aspirin triggers anti-inflammatory lipid mediators with gender implications. Compr Ther. 2006; 32(3):150-7. PMID: 17435267.
    Citations: 5     Fields:    Translation:HumansCells
  60. Hasturk H, Kantarci A, Ohira T, Arita M, Ebrahimi N, Chiang N, Petasis NA, Levy BD, Serhan CN, Van Dyke TE. RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. FASEB J. 2006 Feb; 20(2):401-3. PMID: 16373400.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  61. Chiang N, Hurwitz S, Ridker PM, Serhan CN. Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: a randomized human trial. Arterioscler Thromb Vasc Biol. 2006 Feb; 26(2):e14-7. PMID: 16293793.
    Citations: 19     Fields:    Translation:HumansCells
  62. Chiang N, Arita M, Serhan CN. Anti-inflammatory circuitry: lipoxin, aspirin-triggered lipoxins and their receptor ALX. Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct; 73(3-4):163-77. PMID: 16125378.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  63. Bannenberg GL, Chiang N, Ariel A, Arita M, Tjonahen E, Gotlinger KH, Hong S, Serhan CN. Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol. 2005 Apr 01; 174(7):4345-55. PMID: 15778399.
    Citations: 212     Fields:    Translation:AnimalsCells
  64. Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med. 2005 Mar 07; 201(5):713-22. PMID: 15753205.
    Citations: 239     Fields:    Translation:HumansAnimalsCells
  65. Chiang N, Serhan CN. Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. Discov Med. 2004 Dec; 4(24):470-5. PMID: 20704950.
    Citations: 6     Fields:    
  66. Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN. Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A. 2004 Oct 19; 101(42):15178-83. PMID: 15471991.
    Citations: 65     Fields:    Translation:HumansCTClinical Trials
  67. Serhan CN, Chiang N. Novel endogenous small molecules as the checkpoint controllers in inflammation and resolution: entrée for resoleomics. Rheum Dis Clin North Am. 2004 Feb; 30(1):69-95. PMID: 15061569.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  68. Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, Chiang N, Serhan CN, Bazan NG. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem. 2003 Oct 31; 278(44):43807-17. PMID: 12923200.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
  69. Ariel A, Chiang N, Arita M, Petasis NA, Serhan CN. Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. J Immunol. 2003 Jun 15; 170(12):6266-72. PMID: 12794159.
    Citations: 48     Fields:    Translation:HumansCells
  70. Chiang N, Takano T, Arita M, Watanabe S, Serhan CN. A novel rat lipoxin A4 receptor that is conserved in structure and function. Br J Pharmacol. 2003 May; 139(1):89-98. PMID: 12746227.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  71. Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN. Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med. 2002 Nov; 8(11):1296-302. PMID: 12368905.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  72. Serhan CN, Chiang N. Lipid-derived mediators in endogenous anti-inflammation and resolution: lipoxins and aspirin-triggered 15-epi-lipoxins. ScientificWorldJournal. 2002 Jan 22; 2:169-204. PMID: 12806051.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  73. Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària J. Aspirin-triggered 15-epi-lipoxin A4 biosynthesis in rat liver cells. Adv Exp Med Biol. 2002; 507:199-209. PMID: 12664586.
    Citations:    Fields:    Translation:AnimalsCells
  74. Serhan CN, Fierro IM, Chiang N, Pouliot M. Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. J Immunol. 2001 Mar 15; 166(6):3650-4. PMID: 11238602.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  75. Gronert K, Martinsson-Niskanen T, Ravasi S, Chiang N, Serhan CN. Selectivity of recombinant human leukotriene D(4), leukotriene B(4), and lipoxin A(4) receptors with aspirin-triggered 15-epi-LXA(4) and regulation of vascular and inflammatory responses. Am J Pathol. 2001 Jan; 158(1):3-9. PMID: 11141472.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Serhan CN, Clish CB, Brannon J, Colgan SP, Gronert K, Chiang N. Anti-microinflammatory lipid signals generated from dietary N-3 fatty acids via cyclooxygenase-2 and transcellular processing: a novel mechanism for NSAID and N-3 PUFA therapeutic actions. J Physiol Pharmacol. 2000 Dec; 51(4 Pt 1):643-54. PMID: 11192938.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  77. Serhan CN, Clish CB, Brannon J, Colgan SP, Chiang N, Gronert K. Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med. 2000 Oct 16; 192(8):1197-204. PMID: 11034610.
    Citations: 295     Fields:    Translation:HumansAnimalsCells
  78. Clish CB, Levy BD, Chiang N, Tai HH, Serhan CN. Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-onoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation. J Biol Chem. 2000 Aug 18; 275(33):25372-80. PMID: 10837478.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  79. Sanak M, Levy BD, Clish CB, Chiang N, Gronert K, Mastalerz L, Serhan CN, Szczeklik A. Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J. 2000 Jul; 16(1):44-9. PMID: 10933083.
    Citations: 38     Fields:    Translation:Humans
  80. Chiang N, Fierro IM, Gronert K, Serhan CN. Activation of lipoxin A(4) receptors by aspirin-triggered lipoxins and select peptides evokes ligand-specific responses in inflammation. J Exp Med. 2000 Apr 03; 191(7):1197-208. PMID: 10748237.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  81. Serhan CN, Takano T, Chiang N, Gronert K, Clish CB. Formation of endogenous "antiinflammatory" lipid mediators by transcellular biosynthesis. Lipoxins and aspirin-triggered lipoxins inhibit neutrophil recruitment and vascular permeability. Am J Respir Crit Care Med. 2000 Feb; 161(2 Pt 2):S95-S101. PMID: 10673235.
    Citations: 16     Fields:    Translation:Animals
  82. Serhan CN, Levy BD, Clish CB, Gronert K, Chiang N. Lipoxins, aspirin-triggered 15-epi-lipoxin stable analogs and their receptors in anti-inflammation: a window for therapeutic opportunity. Ernst Schering Res Found Workshop. 2000; (31):143-85. PMID: 10943332.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  83. Titos E, Chiang N, Serhan CN, Romano M, Gaya J, Pueyo G, Clària J. Hepatocytes are a rich source of novel aspirin-triggered 15-epi-lipoxin A(4). Am J Physiol. 1999 11; 277(5):C870-7. PMID: 10564079.
    Citations: 11     Fields:    Translation:AnimalsCells
  84. Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN. Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999 Aug; 104(3):309-16. PMID: 10430612.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  85. Serhan CN, Takano T, Gronert K, Chiang N, Clish CB. Lipoxin and aspirin-triggered 15-epi-lipoxin cellular interactions anti-inflammatory lipid mediators. Clin Chem Lab Med. 1999 Mar; 37(3):299-309. PMID: 10353476.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  86. Chiang N, Takano T, Clish CB, Petasis NA, Tai HH, Serhan CN. Aspirin-triggered 15-epi-lipoxin A4 (ATL) generation by human leukocytes and murine peritonitis exudates: development of a specific 15-epi-LXA4 ELISA. J Pharmacol Exp Ther. 1998 Nov; 287(2):779-90. PMID: 9808710.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  87. Chiang N, Tai HH. The role of N-glycosylation of human thromboxane A2 receptor in ligand binding. Arch Biochem Biophys. 1998 Apr 15; 352(2):207-13. PMID: 9587408.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  88. Taylor MF, Wang M, Bhattacharyya AK, Chiang N, Tai HH, Collins DC. Expression of rat steroid 5 alpha-reductase (isozyme-1) in Spodoptera frugiperda, SF21, insect cells: expression of rat steroid 5 alpha-reductase. Steroids. 1997 Apr; 62(4):373-8. PMID: 9090798.
    Citations: 1     Fields:    Translation:AnimalsCells
  89. Tai HH, Huang C, Chiang N. Structure and function of prostanoid receptors as revealed by site-directed mutagenesis. Adv Exp Med Biol. 1997; 407:205-9. PMID: 9321954.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  90. Chiang N, Kan WM, Tai HH. Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells. Arch Biochem Biophys. 1996 Oct 01; 334(1):9-17. PMID: 8837733.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.