Harvard Catalyst Profiles

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Tatjana Claudia Jakobs, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY031708 (RIZZO, JOSEPH F.) Sep 30, 2021 - Aug 31, 2024
    NIH
    Cross-species vascular anatomy and sensitivity to intraocular pressure in glaucoma
    Role: Co-Principal Investigator
  2. R01EY019703 (JAKOBS, TATJANA CLAUDIA) Sep 30, 2009 - Feb 29, 2024
    NIH
    Cell Biology of Astrocyte-Ganglion Cell Interactions in the Retina and Optic Nerve
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. Loss of epigenetic information as a cause of mammalian aging. Cell. 2023 Jan 19; 186(2):305-326.e27. PMID: 36638792.
    Citations:    Fields:    
  2. Li S, Jakobs TC. Secreted phosphoprotein 1 slows neurodegeneration and rescues visual function in mouse models of aging and glaucoma. Cell Rep. 2022 12 27; 41(13):111880. PMID: 36577373; PMCID: PMC9847489.
    Citations:    Fields:    Translation:AnimalsCells
  3. Hu B, Huang Y, Jakobs TC, Kang Q, Lv Z, Liu W, Wang R. Viability of mitochondria-labeled retinal ganglion cells in organotypic retinal explant cultures by two methods. Exp Eye Res. 2023 Jan; 226:109311. PMID: 36403849.
    Citations:    Fields:    Translation:AnimalsCells
  4. Tan Z, Guo Y, Shrestha M, Sun D, Gregory-Ksander M, Jakobs TC. Microglia depletion exacerbates retinal ganglion cell loss in a mouse model of glaucoma. Exp Eye Res. 2022 12; 225:109273. PMID: 36206859.
    Citations:    Fields:    Translation:AnimalsCells
  5. Waxman S, Brazile BL, Yang B, Lee PY, Hua Y, Gogola AL, Lam P, Voorhees AP, Rizzo JF, Jakobs TC, Sigal IA. Lamina cribrosa vessel and collagen beam networks are distinct. Exp Eye Res. 2022 02; 215:108916. PMID: 34973204; PMCID: PMC8923914.
    Citations: 2     Fields:    Translation:HumansCells
  6. Brazile BL, Yang B, Waxman S, Lam P, Voorhees AP, Hua Y, Loewen RT, Loewen NA, Rizzo JF, Jakobs T, Sigal IA. Lamina Cribrosa Capillaries Straighten as Intraocular Pressure Increases. Invest Ophthalmol Vis Sci. 2020 10 01; 61(12):2. PMID: 33001158.
    Citations: 6     Fields:    Translation:Animals
  7. Zhu Y, Pappas AC, Wang R, Seifert P, Sun D, Jakobs TC. Ultrastructural Morphology of the Optic Nerve Head in Aged and Glaucomatous Mice. Invest Ophthalmol Vis Sci. 2018 08 01; 59(10):3984-3996. PMID: 30098187; PMCID: PMC6082327.
    Citations: 9     Fields:    Translation:AnimalsCells
  8. Choi HJ, Wang R, Jakobs TC. Single-Cell Dissociation and Characterization in the Murine Retina and Optic Nerve. Methods Mol Biol. 2018; 1695:311-334. PMID: 29190033.
    Citations: 1     Fields:    Translation:Animals
  9. Sun D, Moore S, Jakobs TC. Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries. J Exp Med. 2017 05 01; 214(5):1411-1430. PMID: 28416649; PMCID: PMC5413323.
    Citations: 49     Fields:    Translation:AnimalsCells
  10. Tamm ER, Ethier CR. Biological aspects of axonal damage in glaucoma: A brief review. Exp Eye Res. 2017 04; 157:5-12. PMID: 28223179; PMCID: PMC6545378.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  11. Jakobs TC. Ex Vivo Imaging of the Murine Optic Nerve Head. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):734. PMID: 28152143.
    Citations:    Fields:    Translation:HumansAnimals
  12. Wang R, Seifert P, Jakobs TC. Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype. Invest Ophthalmol Vis Sci. 2017 02 01; 58(2):924-932. PMID: 28170536; PMCID: PMC5300248.
    Citations: 31     Fields:    Translation:AnimalsCells
  13. Gao S, Jakobs TC. Mice Homozygous for a Deletion in the Glaucoma Susceptibility Locus INK4 Show Increased Vulnerability of Retinal Ganglion Cells to Elevated Intraocular Pressure. Am J Pathol. 2016 Apr; 186(4):985-1005. PMID: 26883755; PMCID: PMC5848263.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  14. Berry RH, Qu J, John SW, Howell GR, Jakobs TC. Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma. PLoS One. 2015; 10(12):e0144341. PMID: 26637126.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Choi HJ, Sun D, Jakobs TC. Astrocytes in the optic nerve head express putative mechanosensitive channels. Mol Vis. 2015; 21:749-66. PMID: 26236150; PMCID: PMC4502055.
    Citations: 46     Fields:    Translation:AnimalsCells
  16. Choi HJ, Sun D, Jakobs TC. Isolation of intact astrocytes from the optic nerve head of adult mice. Exp Eye Res. 2015 Aug; 137:103-10. PMID: 26093274; PMCID: PMC4523456.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Jakobs TC. Differential gene expression in glaucoma. Cold Spring Harb Perspect Med. 2014 Jul 01; 4(7):a020636. PMID: 24985133.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  18. Qu J, Jakobs TC. The Time Course of Gene Expression during Reactive Gliosis in the Optic Nerve. PLoS One. 2013; 8(6):e67094. PMID: 23826199.
    Citations: 56     Fields:    Translation:AnimalsCells
  19. Sun D, Qu J, Jakobs TC. Reversible reactivity by optic nerve astrocytes. Glia. 2013 Aug; 61(8):1218-35. PMID: 23650091.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  20. Lye-Barthel M, Sun D, Jakobs TC. Morphology of astrocytes in a glaucomatous optic nerve. Invest Ophthalmol Vis Sci. 2013 Feb 01; 54(2):909-17. PMID: 23322566.
    Citations: 55     Fields:    Translation:AnimalsCells
  21. Sun D, Jakobs TC. Structural remodeling of astrocytes in the injured CNS. Neuroscientist. 2012 Dec; 18(6):567-88. PMID: 21982954.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  22. Koizumi A, Jakobs TC, Masland RH. Regular mosaic of synaptic contacts among three retinal neurons. J Comp Neurol. 2011 Feb 01; 519(2):341-57. PMID: 21165978.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. Structural remodeling of fibrous astrocytes after axonal injury. J Neurosci. 2010 Oct 20; 30(42):14008-19. PMID: 20962222.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  24. Sun D, Lye-Barthel M, Masland RH, Jakobs TC. The morphology and spatial arrangement of astrocytes in the optic nerve head of the mouse. J Comp Neurol. 2009 Sep 01; 516(1):1-19. PMID: 19562764.
    Citations: 87     Fields:    Translation:AnimalsCells
  25. Jakobs TC, Koizumi A, Masland RH. The spatial distribution of glutamatergic inputs to dendrites of retinal ganglion cells. J Comp Neurol. 2008 Sep 10; 510(2):221-36. PMID: 18623177.
    Citations: 31     Fields:    Translation:AnimalsCells
  26. Howell GR, Libby RT, Jakobs TC, Smith RS, Phalan FC, Barter JW, Barbay JM, Marchant JK, Mahesh N, Porciatti V, Whitmore AV, Masland RH, John SW. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol. 2007 Dec 31; 179(7):1523-37. PMID: 18158332; PMCID: PMC2373494.
    Citations: 304     Fields:    Translation:AnimalsCells
  27. Jakobs TC, Ben Y, Masland RH. Expression of mRNA for glutamate receptor subunits distinguishes the major classes of retinal neurons, but is less specific for individual cell types. Mol Vis. 2007 Jun 18; 13:933-48. PMID: 17653033; PMCID: PMC2774459.
    Citations: 30     Fields:    Translation:AnimalsCells
  28. Lye MH, Jakobs TC, Masland RH, Koizumi A. Organotypic culture of adult rabbit retina. J Vis Exp. 2007; (3):190. PMID: 18978996.
    Citations: 6     Fields:    Translation:Animals
  29. Koizumi A, Zeck G, Ben Y, Masland RH, Jakobs TC. Organotypic culture of physiologically functional adult mammalian retinas. PLoS One. 2007 Feb 21; 2(2):e221. PMID: 17311097.
    Citations: 24     Fields:    Translation:AnimalsCells
  30. Enoki R, Jakobs TC, Koizumi A. Horizontal slice preparation of the retina. J Vis Exp. 2006 Nov 20; (1):108. PMID: 18704185.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Jakobs TC, Libby RT, Ben Y, John SW, Masland RH. Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice. J Cell Biol. 2005 Oct 24; 171(2):313-25. PMID: 16247030; PMCID: PMC2171185.
    Citations: 206     Fields:    Translation:AnimalsCells
  32. Lin B, Jakobs TC, Masland RH. Different functional types of bipolar cells use different gap-junctional proteins. J Neurosci. 2005 Jul 13; 25(28):6696-701. PMID: 16014731; PMCID: PMC6725416.
    Citations: 22     Fields:    Translation:AnimalsCells
  33. Koizumi A, Jakobs TC, Masland RH. Inward rectifying currents stabilize the membrane potential in dendrites of mouse amacrine cells: patch-clamp recordings and single-cell RT-PCR. Mol Vis. 2004 May 13; 10:328-40. PMID: 15152185.
    Citations: 16     Fields:    Translation:AnimalsCells
  34. Jakobs TC, Ben Y, Masland RH. CD15 immunoreactive amacrine cells in the mouse retina. J Comp Neurol. 2003 Oct 20; 465(3):361-71. PMID: 12966561.
    Citations: 16     Fields:    Translation:AnimalsCells
  35. Sugawara H, Egashira M, Harada N, Jakobs TC, Yoshiura K, Kishino T, Ohta T, Niikawa N, Matsumoto N. Breakpoint analysis of a familial balanced translocation t(2;8)(q31;p21) associated with mesomelic dysplasia. J Med Genet. 2002 Jul; 39(7):E34. PMID: 12114491; PMCID: PMC1735173.
    Citations: 1     Fields:    Translation:HumansCells
  36. Jakobs TC, Mentrup B, Schmutzler C, Dreher I, Köhrle J. Proinflammatory cytokines inhibit the expression and function of human type I 5'-deiodinase in HepG2 hepatocarcinoma cells. Eur J Endocrinol. 2002 Apr; 146(4):559-66. PMID: 11916626.
    Citations: 20     Fields:    Translation:HumansCells
  37. Winzer R, Schmutzler C, Jakobs TC, Ebert R, Rendl J, Reiners C, Jakob F, Köhrle J. Reverse transcriptase-polymerase chain reaction analysis of thyrocyte-relevant genes in fine-needle aspiration biopsies of the human thyroid. Thyroid. 1998 Nov; 8(11):981-7. PMID: 9848710.
    Citations: 4     Fields:    Translation:HumansCells
  38. schmutzler C, Brtko J, Winzer R, Jakobs TC, Meissner-Weigl J, Simon D, Goretzki PE, Köhrle J. Functional retinoid and thyroid hormone receptors in human thyroid-carcinoma cell lines and tissues. Int J Cancer. 1998 May 04; 76(3):368-76. PMID: 9579574.
    Citations: 6     Fields:    Translation:HumansCells
  39. Dreher I, Jakobs TC, Köhrle J. Cloning and characterization of the human selenoprotein P promoter. Response of selenoprotein P expression to cytokines in liver cells. J Biol Chem. 1997 Nov 14; 272(46):29364-71. PMID: 9361018.
    Citations: 27     Fields:    Translation:HumansCells
  40. Jakobs TC, Schmutzler C, Meissner J, Köhrle J. The promoter of the human type I 5'-deiodinase gene--mapping of the transcription start site and identification of a DR+4 thyroid-hormone-responsive element. Eur J Biochem. 1997 Jul 01; 247(1):288-97. PMID: 9249039.
    Citations: 18     Fields:    Translation:HumansCells
  41. Jakobs TC, Koehler MR, Schmutzler C, Glaser F, Schmid M, Köhrle J. Structure of the human type I iodothyronine 5'-deiodinase gene and localization to chromosome 1p32-p33. Genomics. 1997 Jun 01; 42(2):361-3. PMID: 9192862.
    Citations: 2     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.