Samuel Rabkin | Harvard Catalyst Profiles

We are developing oncolytic herpes simplex viruses (oHSVs) for cancer therapy, in particular for glioblastoma. We have isolated a spontaneously arising 'large plaque' mutant of oHSV. This mutant needs to be characterized in depth, both in vitro and in vivo. This includes bioinformatic analysis of genome sequences and RNA expression in infected cells to identify the sequence alterations responsible for the phenotype and the mechanism of action. In vitro, the biology of the mutant and its impact on cancer and normal cells will be studied. In vivo, the efficacy of the mutant in glioblastoma stem-like cell tumor models, human and mouse, that we have developed, and its 'safety' will be determined.

completed student projects

Infection Study of Human Neural Stem Cells with Oncolytic HSV

Summer, 04/02/07 - 08/03/07

Research

research activities and funding

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.

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R21CA164726 (RABKIN, SAMUEL DAVID) Jul 20, 2012 - Jun 30, 2015

NIH

Selective Differentiation of Glioblastoma Stem Cells

Role: Principal Investigator
R01CA160762 (RABKIN, SAMUEL DAVID) May 3, 2012 - Jan 31, 2025

NIH

Targeting tumorigenic pathways in glioblastoma with oncolytic HSV

Role: Principal Investigator
P30NS045776 (BREAKEFIELD, XANDRA OWENS) May 1, 2003 - May 31, 2019

NIH

Interdepartmental Neuroscience Center

Role: Co-Principal Investigator
R01NS033342 (RABKIN, SAMUEL D) Aug 1, 1994 - Apr 30, 2005

NIH

GENE DELIVERY TO THE CNS TO MODULATE EPILEPSY

Role: Principal Investigator

Bibliographic

selected publications

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