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Francis W. Luscinskas, Ph.D.

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Iberdrola Visiting Professor
A.H.A. Established Investigator Award
Excellence in Tutorial Award

My interests are in the cell biology of leukocytes and vascular endothelial cells and their adhesive interactions in the context of the pathophysiology of the inflammatory response. Prior to closing my lab in December 2021, my lab employed mouse and human models to understand the molecular mechanisms involved leukocyte recruitment and in regulating vascular permeability, focusing on the role of vascular endothelial expressed adhesion molecules (e.g., ICAM-1 and CD47, and the adherens junction protein, Vascular Endothelial-cadherin (VE-cadherin, cadherin-5). My lab team combined expertise in endothelial cell biochemistry, immunology and live cell fluorescence microscopy techniques with my collaborators, Drs. Kevin Croce, Andrew Lichtman, and Tanya Mayadas from BWH (MGB) and Charles Parkos, Chairman of Pathology, University of Michigan, who have significant expertise in intravital microscopy of the microcirculation and have established several in vivo experimental models and in vitro models of inflammation and vascular permeability. My laboratory was located in the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital (Mass General Brigham).

Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
Summer, 05/25/05 - 09/02/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL125780 (LUSCINSKAS, FRANCIS W.) May 1, 2016 - Sep 30, 2020
    CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking
    Role: Principal Investigator
  2. R13CA186413 (LUSCINSKAS, FRANCIS W.) Apr 24, 2014 - Apr 23, 2015
    2014 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  3. R13CA177075 (LUSCINSKAS, FRANCIS W.) Apr 1, 2013 - Mar 31, 2014
    2013 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  4. R01HL065090 (LUSCINSKAS, FRANCIS W.) Sep 30, 1999 - Jul 31, 2005
    Role: Principal Investigator
  5. R01HL053993 (LUSCINSKAS, FRANCIS W.) Aug 1, 1996 - Jun 30, 2011
    Endothelial Regulation of Leukocyte Transmigration
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.