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Francis W. Luscinskas, Ph.D.

Title
Institution
Department
Address
Phone
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Biography
awards and honors
1997
Iberdrola Visiting Professor
2000
A.H.A. Established Investigator Award
2007
Excellence in Tutorial Award

Overview
overview
My interests are in the cell biology of leukocytes and vascular endothelial cells and their adhesive interactions in the context of the pathophysiology of the inflammatory response. Prior to closing my lab in December 2021, my lab employed mouse and human models to understand the molecular mechanisms involved leukocyte recruitment and in regulating vascular permeability, focusing on the role of vascular endothelial expressed adhesion molecules (e.g., ICAM-1 and CD47, and the adherens junction protein, Vascular Endothelial-cadherin (VE-cadherin, cadherin-5). My lab team combined expertise in endothelial cell biochemistry, immunology and live cell fluorescence microscopy techniques with my collaborators, Drs. Kevin Croce, Andrew Lichtman, and Tanya Mayadas from BWH (MGB) and Charles Parkos, Chairman of Pathology, University of Michigan, who have significant expertise in intravital microscopy of the microcirculation and have established several in vivo experimental models and in vitro models of inflammation and vascular permeability. My laboratory was located in the Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital (Mass General Brigham).

Mentoring
completed student projects
Role of Endothelial JAM-C in Leukocyte Recruitment Under Shear Flow in vitro
Summer, 05/25/05 - 09/02/05

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL125780 (LUSCINSKAS, FRANCIS W.) May 1, 2016 - Sep 30, 2020
    NIH
    CD47 Regulation of Leukocyte Integrins during Leukocyte Trafficking
    Role: Principal Investigator
  2. R13CA186413 (LUSCINSKAS, FRANCIS W.) Apr 24, 2014 - Apr 23, 2015
    NIH
    2014 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  3. R13CA177075 (LUSCINSKAS, FRANCIS W.) Apr 1, 2013 - Mar 31, 2014
    NIH
    2013 Annual Meeting of the American Society for Investigative Pathology
    Role: Principal Investigator
  4. R01HL065090 (LUSCINSKAS, FRANCIS W.) Sep 30, 1999 - Jul 31, 2005
    NIH
    ENDOTHELIAL CELL DYSFUNCTION IN CHRONIC IMMUNE DISEASES
    Role: Principal Investigator
  5. R01HL053993 (LUSCINSKAS, FRANCIS W.) Aug 1, 1996 - Jun 30, 2011
    NIH
    Endothelial Regulation of Leukocyte Transmigration
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Autio A, Wang H, Velázquez F, Newton G, Parkos CA, Engel P, Engelbertsen D, Lichtman AH, Luscinskas FW. SIRPa - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen. PLoS One. 2022; 17(4):e0266566. PMID: 35413056; PMCID: PMC9004769.
    Citations:    Fields:    Translation:AnimalsCells
  2. Wang H, Newton G, Wu L, Lin LL, Miracco AS, Natesan S, Luscinskas FW. CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE. JCI Insight. 2021 11 08; 6(21). PMID: 34591795; PMCID: PMC8663579.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Anastasiou M, Newton GA, Kaur K, Carrillo-Salinas FJ, Smolgovsky SA, Bayer AL, Ilyukha V, Sharma S, Poltorak A, Luscinskas FW, Alcaide P. Endothelial STING controls T cell transmigration in an IFNI-dependent manner. JCI Insight. 2021 08 09; 6(15). PMID: 34156982; PMCID: PMC8410041.
    Citations: 8     Fields:    Translation:AnimalsCells
  4. Liu J, Yang C, Liu T, Deng Z, Fang W, Zhang X, Li J, Huang Q, Liu C, Wang Y, Yang D, Sukhova GK, Lindholt JS, Diederichsen A, Rasmussen LM, Li D, Newton G, Luscinskas FW, Liu L, Libby P, Wang J, Guo J, Shi GP. Eosinophils improve cardiac function after myocardial infarction. Nat Commun. 2020 12 16; 11(1):6396. PMID: 33328477.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  5. Chakraborty A, Staudinger C, King SL, Erickson FC, Lau LS, Bernasconi A, Luscinskas FW, Perlyn C, Dimitroff CJ. Galectin-9 bridges human B cells to vascular endothelium while programming regulatory pathways. J Autoimmun. 2021 02; 117:102575. PMID: 33285511; PMCID: PMC7856191.
    Citations: 5     Fields:    Translation:HumansCells
  6. Janssen E, Tohme M, Butts J, Giguere S, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS. DOCK8 is essential for LFA-1-dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 08 06; 5(15). PMID: 32573493.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Azcutia V, Kelm M, Luissint AC, Boerner K, Flemming S, Quiros M, Newton G, Nusrat A, Luscinskas FW, Parkos CA. Neutrophil expressed CD47 regulates CD11b/CD18-dependent neutrophil transepithelial migration in the intestine in vivo. Mucosal Immunol. 2021 03; 14(2):331-341. PMID: 32561828; PMCID: PMC7749029.
    Citations: 9     Fields:    Translation:AnimalsCells
  8. Jain S, Van Scoyk A, Morgan EA, Matthews A, Stevenson K, Newton G, Powers F, Autio A, Louissaint A, Pontini G, Aster JC, Luscinskas FW, Weinstock DM. Targeted inhibition of CD47-SIRPa requires Fc-Fc?R interactions to maximize activity in T-cell lymphomas. Blood. 2019 10 24; 134(17):1430-1440. PMID: 31383641; PMCID: PMC6839960.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  9. Engelbertsen D, Autio A, Verwilligen RAF, Depuydt MAC, Newton G, Rattik S, Levinsohn E, Saggu G, Jarolim P, Wang H, Velazquez F, Lichtman AH, Luscinskas FW. Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Sci Rep. 2019 07 23; 9(1):10608. PMID: 31337788.
    Citations: 21     Fields:    Translation:AnimalsCells
  10. Folco EJ, Mawson TL, Vromman A, Bernardes-Souza B, Franck G, Persson O, Nakamura M, Newton G, Luscinskas FW, Libby P. Neutrophil Extracellular Traps Induce Endothelial Cell Activation and Tissue Factor Production Through Interleukin-1a and Cathepsin G. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1901-1912. PMID: 29976772; PMCID: PMC6202190.
    Citations: 117     Fields:    Translation:HumansCells
  11. Miyabe Y, Miyabe C, Murooka TT, Kim EY, Newton GA, Kim ND, Haribabu B, Luscinskas FW, Mempel TR, Luster AD. Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan; 2(7). PMID: 28529998.
    Citations: 38     Fields:    
  12. Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW. Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017 02; 101(2):493-505. PMID: 27965383; PMCID: PMC6608006.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  13. Janssen E, Tohme M, Hedayat M, Leick M, Kumari S, Ramesh N, Massaad MJ, Ullas S, Azcutia V, Goodnow CC, Randall KL, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine DJ, Luscinskas FW, Geha RS. A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest. 2016 10 03; 126(10):3837-3851. PMID: 27599296; PMCID: PMC5096816.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  14. Zahr A, Alcaide P, Yang J, Jones A, Gregory M, dela Paz NG, Patel-Hett S, Nevers T, Koirala A, Luscinskas FW, Saint-Geniez M, Ksander B, D'Amore PA, Argüeso P. Endomucin prevents leukocyte-endothelial cell adhesion and has a critical role under resting and inflammatory conditions. Nat Commun. 2016 Feb 02; 7:10363. PMID: 26831939.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  15. Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015 Dec 18; 6:10182. PMID: 26680259.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Wang G, van Driel BJ, Liao G, O'Keeffe MS, Halibozek PJ, Flipse J, Yigit B, Azcutia V, Luscinskas FW, Wang N, Terhorst C. Migration of myeloid cells during inflammation is differentially regulated by the cell surface receptors Slamf1 and Slamf8. PLoS One. 2015; 10(3):e0121968. PMID: 25799045.
    Citations: 23     Fields:    Translation:AnimalsCells
  17. Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep. 2015 Mar 17; 10(10):1655-1664. PMID: 25772353; PMCID: PMC4567551.
    Citations: 31     Fields:    
  18. Luscinskas FW, Leick M, Newton G, Nusrat A. Introduction for the special issue on "Tissue Barriers in Inflammation". Tissue Barriers. 2015; 3(1-2):e1015825. PMID: 25927017.
    Citations: 2     Fields:    
  19. Brown JD, Lin CY, Duan Q, Griffin G, Federation A, Paranal RM, Bair S, Newton G, Lichtman A, Kung A, Yang T, Wang H, Luscinskas FW, Croce K, Bradner JE, Plutzky J. NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell. 2014 Oct 23; 56(2):219-231. PMID: 25263595.
    Citations: 293     Fields:    Translation:HumansAnimalsCells
  20. Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54. PMID: 25246631.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Luscinskas FW, Imhof BA. Introduction for the special issue on new paradigms in leukocyte trafficking, lessons for therapeutics. Semin Immunopathol. 2014 Mar; 36(2):133-6. PMID: 24715029.
    Citations:    Fields:    Translation:HumansAnimalsCells
  22. Leick M, Azcutia V, Newton G, Luscinskas FW. Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies. Cell Tissue Res. 2014 Mar; 355(3):647-56. PMID: 24562377.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  23. Luscinskas FW. Neutrophil recruitment: perivascular macrophages 'duke it out' with Staphylococcus aureus. Nat Immunol. 2014 Jan; 15(1):10-1. PMID: 24352318.
    Citations:    Fields:    Translation:AnimalsCells
  24. Luscinskas FW. CXCL1 excess stops neutrophils in their tracks. Blood. 2013 Nov 28; 122(23):3708-10. PMID: 24288409; PMCID: PMC3843234.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Azcutia V, Routledge M, Williams MR, Newton G, Frazier WA, Manica A, Croce KJ, Parkos CA, Schmider AB, Turman MV, Soberman RJ, Luscinskas FW. CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions. Mol Biol Cell. 2013 Nov; 24(21):3358-68. PMID: 24006483.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  26. Martinelli R, Newton G, Carman CV, Greenwood J, Luscinskas FW. Novel role of CD47 in rat microvascular endothelium: signaling and regulation of T-cell transendothelial migration. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2566-76. PMID: 23990210.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  27. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13. PMID: 24052946.
    Citations: 86     Fields:    Translation:HumansCells
  28. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. PMID: 23623383.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  29. Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. 2012 Dec; 122(12):4424-38. PMID: 23187125; PMCID: PMC3533553.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  30. van Driel B, Liao G, Romero X, O'Keeffe MS, Wang G, Faubion WA, Berger SB, Magelky EM, Manocha M, Azcutia V, Grisham M, Luscinskas FW, Mizoguchi E, de Waal Malefyt R, Reinecker HC, Bhan AK, Wang N, Terhorst C. Signaling lymphocyte activation molecule regulates development of colitis in mice. Gastroenterology. 2012 Dec; 143(6):1544-1554.e7. PMID: 22960654; PMCID: PMC3578298.
    Citations: 12     Fields:    Translation:AnimalsCells
  31. Zheng C, Azcutia V, Aikawa E, Figueiredo JL, Croce K, Sonoki H, Sacks FM, Luscinskas FW, Aikawa M. Statins suppress apolipoprotein CIII-induced vascular endothelial cell activation and monocyte adhesion. Eur Heart J. 2013 Feb; 34(8):615-24. PMID: 22927557.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  32. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62. PMID: 22815286; PMCID: PMC3424398.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Alcaide P, Martinelli R, Newton G, Williams MR, Adam A, Vincent PA, Luscinskas FW. p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C385-95. PMID: 22648953.
    Citations: 18     Fields:    Translation:HumansCells
  34. Griffin GK, Newton G, Tarrio ML, Bu DX, Maganto-Garcia E, Azcutia V, Alcaide P, Grabie N, Luscinskas FW, Croce KJ, Lichtman AH. IL-17 and TNF-a sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation. J Immunol. 2012 Jun 15; 188(12):6287-99. PMID: 22566565; PMCID: PMC3370121.
    Citations: 153     Fields:    Translation:AnimalsCells
  35. Luscinskas FW. FAK and PAX-illin get involved in leukocyte diapedesis. Eur J Immunol. 2012 Feb; 42(2):296-8. PMID: 22266717.
    Citations: 1     Fields:    Translation:HumansCells
  36. Alcaide P, Maganto-Garcia E, Newton G, Travers R, Croce KJ, Bu DX, Luscinskas FW, Lichtman AH. Difference in Th1 and Th17 lymphocyte adhesion to endothelium. J Immunol. 2012 Feb 01; 188(3):1421-30. PMID: 22219321; PMCID: PMC3262911.
    Citations: 31     Fields:    Translation:AnimalsCells
  37. Maganto-García E, Bu DX, Tarrio ML, Alcaide P, Newton G, Griffin GK, Croce KJ, Luscinskas FW, Lichtman AH, Grabie N. Foxp3+-inducible regulatory T cells suppress endothelial activation and leukocyte recruitment. J Immunol. 2011 Oct 01; 187(7):3521-9. PMID: 21873519; PMCID: PMC3217244.
    Citations: 37     Fields:    Translation:AnimalsCells
  38. Williams MR, Azcutia V, Newton G, Alcaide P, Luscinskas FW. Emerging mechanisms of neutrophil recruitment across endothelium. Trends Immunol. 2011 Oct; 32(10):461-9. PMID: 21839681.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  39. Williams MR, Luscinskas FW. Leukocyte rolling and adhesion via ICAM-1 signals to endothelial permeability. Focus on "Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1". Am J Physiol Cell Physiol. 2011 Oct; 301(4):C777-9. PMID: 21775704.
    Citations: 9     Fields:    Translation:AnimalsCells
  40. Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One. 2011 Jan 14; 6(1):e14525. PMID: 21264293.
    Citations: 70     Fields:    Translation:AnimalsCells
  41. Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6. PMID: 20805498.
    Citations: 19     Fields:    Translation:AnimalsCells
  42. Luscinskas FW. Neutrophil CD44 rafts and rolls. Blood. 2010 Jul 22; 116(3):314-5. PMID: 20651082.
    Citations: 1     Fields:    
  43. Azcutia V, Abu-Taha M, Romacho T, Vázquez-Bella M, Matesanz N, Luscinskas FW, Rodríguez-Mañas L, Sanz MJ, Sánchez-Ferrer CF, Peiró C. Inflammation determines the pro-adhesive properties of high extracellular d-glucose in human endothelial cells in vitro and rat microvessels in vivo. PLoS One. 2010 Apr 08; 5(4):e10091. PMID: 20386708.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  44. Alcaide P, Lim YC, Luscinskas FW, Fresno M. Mucin AgC10 from Trypanosoma cruzi Interferes with L-selectin-mediated monocyte adhesion. Infect Immun. 2010 Mar; 78(3):1260-8. PMID: 20065025.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  45. Alcaide P, Auerbach S, Luscinskas FW. Neutrophil recruitment under shear flow: it's all about endothelial cell rings and gaps. Microcirculation. 2009 Jan; 16(1):43-57. PMID: 18720226.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  46. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 2008 Oct 01; 112(7):2770-9. PMID: 18641366; PMCID: PMC2556612.
    Citations: 61     Fields:    Translation:HumansCells
  47. Stefanidakis M, Newton G, Lee WY, Parkos CA, Luscinskas FW. Endothelial CD47 interaction with SIRPgamma is required for human T-cell transendothelial migration under shear flow conditions in vitro. Blood. 2008 Aug 15; 112(4):1280-9. PMID: 18524990; PMCID: PMC2515120.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  48. Noma K, Rikitake Y, Oyama N, Yan G, Alcaide P, Liu PY, Wang H, Ahl D, Sawada N, Okamoto R, Hiroi Y, Shimizu K, Luscinskas FW, Sun J, Liao JK. ROCK1 mediates leukocyte recruitment and neointima formation following vascular injury. J Clin Invest. 2008 May; 118(5):1632-44. PMID: 18414683; PMCID: PMC2293333.
    Citations: 82     Fields:    Translation:AnimalsCells
  49. Rabodzey A, Alcaide P, Luscinskas FW, Ladoux B. Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J. 2008 Aug; 95(3):1428-38. PMID: 18390614.
    Citations: 51     Fields:    Translation:HumansCells
  50. Muller WA, Luscinskas FW. Assays of transendothelial migration in vitro. Methods Enzymol. 2008; 443:155-76. PMID: 18772016.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  51. Rabodzey A, Yao Y, Luscinskas FW, Shaw SK, Dewey CF. Early response of endothelial cells to flow is mediated by VE-cadherin. Cell Commun Adhes. 2007 Sep-Oct; 14(5):195-209. PMID: 18163230.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  52. Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood. 2007 Nov 15; 110(10):3682-90. PMID: 17702895; PMCID: PMC2077316.
    Citations: 59     Fields:    Translation:HumansCells
  53. Rao RM, Yang L, Garcia-Cardena G, Luscinskas FW. Endothelial-dependent mechanisms of leukocyte recruitment to the vascular wall. Circ Res. 2007 Aug 03; 101(3):234-47. PMID: 17673684.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  54. Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M, Imhof BA. JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood. 2007 Oct 01; 110(7):2545-55. PMID: 17625065; PMCID: PMC1988941.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  55. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87. PMID: 17442972.
    Citations: 18     Fields:    Translation:AnimalsCells
  56. Alcaide P, King SL, Dimitroff CJ, Lim YC, Fuhlbrigge RC, Luscinskas FW. The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo. J Invest Dermatol. 2007 Aug; 127(8):1964-72. PMID: 17392823.
    Citations: 33     Fields:    Translation:AnimalsCells
  57. Alcaide P, Jones TG, Lord GM, Glimcher LH, Hallgren J, Arinobu Y, Akashi K, Paterson AM, Gurish MA, Luscinskas FW. Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue. J Exp Med. 2007 Feb 19; 204(2):431-9. PMID: 17296784; PMCID: PMC2118716.
    Citations: 21     Fields:    Translation:AnimalsCells
  58. Lou O, Alcaide P, Luscinskas FW, Muller WA. CD99 is a key mediator of the transendothelial migration of neutrophils. J Immunol. 2007 Jan 15; 178(2):1136-43. PMID: 17202377.
    Citations: 74     Fields:    Translation:HumansCells
  59. Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205. PMID: 17200719; PMCID: PMC1716211.
    Citations: 595     Fields:    Translation:AnimalsCells
  60. Yang L, Kowalski JR, Yacono P, Bajmoczi M, Shaw SK, Froio RM, Golan DE, Thomas SM, Luscinskas FW. Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration. J Immunol. 2006 Nov 01; 177(9):6440-9. PMID: 17056576.
    Citations: 59     Fields:    Translation:HumansCells
  61. Kawakami A, Aikawa M, Alcaide P, Luscinskas FW, Libby P, Sacks FM. Apolipoprotein CIII induces expression of vascular cell adhesion molecule-1 in vascular endothelial cells and increases adhesion of monocytic cells. Circulation. 2006 Aug 15; 114(7):681-7. PMID: 16894036.
    Citations: 111     Fields:    Translation:HumansCells
  62. Cai YH, Alvarez A, Alcaide P, Duramad P, Lim YC, Jarolim P, Lowe JB, Luscinskas FW, Lichtman AH. Abrogation of functional selectin-ligand expression reduces migration of pathogenic CD8+ T cells into heart. J Immunol. 2006 Jun 01; 176(11):6568-75. PMID: 16709814.
    Citations: 9     Fields:    Translation:AnimalsCells
  63. Xie C, Alcaide P, Geisbrecht BV, Schneider D, Herrmann M, Preissner KT, Luscinskas FW, Chavakis T. Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus. J Exp Med. 2006 Apr 17; 203(4):985-94. PMID: 16585266; PMCID: PMC2118278.
    Citations: 26     Fields:    Translation:AnimalsCells
  64. Harari OA, Alcaide P, Ahl D, Luscinskas FW, Liao JK. Absence of TRAM restricts Toll-like receptor 4 signaling in vascular endothelial cells to the MyD88 pathway. Circ Res. 2006 May 12; 98(9):1134-40. PMID: 16574902; PMCID: PMC2701732.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  65. Kawakami A, Aikawa M, Libby P, Alcaide P, Luscinskas FW, Sacks FM. Apolipoprotein CIII in apolipoprotein B lipoproteins enhances the adhesion of human monocytic cells to endothelial cells. Circulation. 2006 Feb 07; 113(5):691-700. PMID: 16461842.
    Citations: 78     Fields:    Translation:HumansCells
  66. Lim YC, Luscinskas FW. Isolation and culture of murine heart and lung endothelial cells for in vitro model systems. Methods Mol Biol. 2006; 341:141-54. PMID: 16799196.
    Citations: 35     Fields:    Translation:AnimalsCells
  67. Yang L, Kowalski JR, Zhan X, Thomas SM, Luscinskas FW. Endothelial cell cortactin phosphorylation by Src contributes to polymorphonuclear leukocyte transmigration in vitro. Circ Res. 2006 Feb 17; 98(3):394-402. PMID: 16385081.
    Citations: 51     Fields:    Translation:HumansCells
  68. Lord GM, Rao RM, Choe H, Sullivan BM, Lichtman AH, Luscinskas FW, Glimcher LH. T-bet is required for optimal proinflammatory CD4+ T-cell trafficking. Blood. 2005 Nov 15; 106(10):3432-9. PMID: 16014561; PMCID: PMC1895048.
    Citations: 138     Fields:    Translation:AnimalsCells
  69. Yang L, Froio RM, Sciuto TE, Dvorak AM, Alon R, Luscinskas FW. ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-alpha-activated vascular endothelium under flow. Blood. 2005 Jul 15; 106(2):584-92. PMID: 15811956; PMCID: PMC1635241.
    Citations: 297     Fields:    Translation:HumansCells
  70. Rao RM, Shaw SK, Kim M, Luscinskas FW. Emerging topics in the regulation of leukocyte transendothelial migration. Microcirculation. 2005 Jan-Feb; 12(1):83-9. PMID: 15804976.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  71. Shaw SK, Ma S, Kim MB, Rao RM, Hartman CU, Froio RM, Yang L, Jones T, Liu Y, Nusrat A, Parkos CA, Luscinskas FW. Coordinated redistribution of leukocyte LFA-1 and endothelial cell ICAM-1 accompany neutrophil transmigration. J Exp Med. 2004 Dec 20; 200(12):1571-80. PMID: 15611287; PMCID: PMC2212000.
    Citations: 106     Fields:    Translation:HumansCells
  72. Rao RM, Betz TV, Lamont DJ, Kim MB, Shaw SK, Froio RM, Baleux F, Arenzana-Seisdedos F, Alon R, Luscinskas FW. Elastase release by transmigrating neutrophils deactivates endothelial-bound SDF-1alpha and attenuates subsequent T lymphocyte transendothelial migration. J Exp Med. 2004 Sep 20; 200(6):713-24. PMID: 15381727; PMCID: PMC2211969.
    Citations: 26     Fields:    Translation:HumansCells
  73. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 01; 105(5):1950-5. PMID: 15374886.
    Citations: 181     Fields:    Translation:HumansCells
  74. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15. PMID: 15136591; PMCID: PMC2211816.
    Citations: 274     Fields:    Translation:HumansCells
  75. Alon R, Luscinskas FW. Crawling and INTEGRating apical cues. Nat Immunol. 2004 Apr; 5(4):351-3. PMID: 15052260.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  76. Liu Y, Shaw SK, Ma S, Yang L, Luscinskas FW, Parkos CA. Regulation of leukocyte transmigration: cell surface interactions and signaling events. J Immunol. 2004 Jan 01; 172(1):7-13. PMID: 14688302.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  77. Kolesnikova TV, Stipp CS, Rao RM, Lane WS, Luscinskas FW, Hemler ME. EWI-2 modulates lymphocyte integrin alpha4beta1 functions. Blood. 2004 Apr 15; 103(8):3013-9. PMID: 15070678.
    Citations: 25     Fields:    Translation:HumansCells
  78. Ehlers R, Ustinov V, Chen Z, Zhang X, Rao R, Luscinskas FW, Lopez J, Plow E, Simon DI. Targeting platelet-leukocyte interactions: identification of the integrin Mac-1 binding site for the platelet counter receptor glycoprotein Ibalpha. J Exp Med. 2003 Oct 06; 198(7):1077-88. PMID: 14530377; PMCID: PMC2194217.
    Citations: 43     Fields:    Translation:HumansCells
  79. Ancuta P, Rao R, Moses A, Mehle A, Shaw SK, Luscinskas FW, Gabuzda D. Fractalkine preferentially mediates arrest and migration of CD16+ monocytes. J Exp Med. 2003 Jun 16; 197(12):1701-7. PMID: 12810688; PMCID: PMC2193954.
    Citations: 201     Fields:    Translation:HumansCells
  80. Lim YC, Garcia-Cardena G, Allport JR, Zervoglos M, Connolly AJ, Gimbrone MA, Luscinskas FW. Heterogeneity of endothelial cells from different organ sites in T-cell subset recruitment. Am J Pathol. 2003 May; 162(5):1591-601. PMID: 12707043; PMCID: PMC1851196.
    Citations: 75     Fields:    Translation:AnimalsCells
  81. Grabie N, Delfs MW, Lim YC, Westrich JR, Luscinskas FW, Lichtman AH. Beta-galactoside alpha2,3-sialyltransferase-I gene expression during Th2 but not Th1 differentiation: implications for core2-glycan formation on cell surface proteins. Eur J Immunol. 2002 Oct; 32(10):2766-72. PMID: 12355428.
    Citations: 8     Fields:    Translation:AnimalsCells
  82. Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK. The role of endothelial cell lateral junctions during leukocyte trafficking. Immunol Rev. 2002 Aug; 186:57-67. PMID: 12234362.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  83. Allport JR, Lim YC, Shipley JM, Senior RM, Shapiro SD, Matsuyoshi N, Vestweber D, Luscinskas FW. Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J Leukoc Biol. 2002 May; 71(5):821-8. PMID: 11994507.
    Citations: 48     Fields:    Translation:AnimalsCells
  84. Boyce JA, Mellor EA, Perkins B, Lim YC, Luscinskas FW. Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions. Blood. 2002 Apr 15; 99(8):2890-6. PMID: 11929779.
    Citations: 19     Fields:    Translation:HumansCells
  85. Luscinskas FW, Ma S, Nusrat A, Parkos CA, Shaw SK. Leukocyte transendothelial migration: a junctional affair. Semin Immunol. 2002 Apr; 14(2):105-13. PMID: 11978082.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  86. Shaw SK, Perkins BN, Lim YC, Liu Y, Nusrat A, Schnell FJ, Parkos CA, Luscinskas FW. Reduced expression of junctional adhesion molecule and platelet/endothelial cell adhesion molecule-1 (CD31) at human vascular endothelial junctions by cytokines tumor necrosis factor-alpha plus interferon-gamma Does not reduce leukocyte transmigration under flow. Am J Pathol. 2001 Dec; 159(6):2281-91. PMID: 11733377; PMCID: PMC1850595.
    Citations: 26     Fields:    Translation:HumansCells
  87. Lim YC, Xie H, Come CE, Alexander SI, Grusby MJ, Lichtman AH, Luscinskas FW. IL-12, STAT4-dependent up-regulation of CD4(+) T cell core 2 beta-1,6-n-acetylglucosaminyltransferase, an enzyme essential for biosynthesis of P-selectin ligands. J Immunol. 2001 Oct 15; 167(8):4476-84. PMID: 11591774.
    Citations: 23     Fields:    Translation:AnimalsCells
  88. Shaw SK, Bamba PS, Perkins BN, Luscinskas FW. Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium. J Immunol. 2001 Aug 15; 167(4):2323-30. PMID: 11490021.
    Citations: 113     Fields:    Translation:HumansCells
  89. Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun; 14(6):693-704. PMID: 11420040.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  90. Luscinskas FW, Shaw SK. The biology of endothelial cell-cell lateral junctions. Microcirculation. 2001 Jun; 8(3):141-2. PMID: 11498777.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  91. Luscinskas FW, Lim YC, Lichtman AH. Wall shear stress: the missing step for T cell transmigration? Nat Immunol. 2001 Jun; 2(6):478-80. PMID: 11376329.
    Citations: 4     Fields:    Translation:HumansCells
  92. Lim YC, Wakelin MW, Henault L, Goetz DJ, Yednock T, Cabañas C, Sánchez-Madrid F, Lichtman AH, Luscinskas FW. Alpha4beta1-integrin activation is necessary for high-efficiency T-cell subset interactions with VCAM-1 under flow. Microcirculation. 2000 Jun; 7(3):201-14. PMID: 10901499.
    Citations: 21     Fields:    Translation:HumansCells
  93. Luscinskas FW, Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Rosenzweig A. C-C and C-X-C chemokines trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Ann N Y Acad Sci. 2000 May; 902:288-93. PMID: 10865849.
    Citations: 17     Fields:    Translation:HumansCells
  94. Barouch FC, Miyamoto K, Allport JR, Fujita K, Bursell SE, Aiello LP, Luscinskas FW, Adamis AP. Integrin-mediated neutrophil adhesion and retinal leukostasis in diabetes. Invest Ophthalmol Vis Sci. 2000 Apr; 41(5):1153-8. PMID: 10752954.
    Citations: 105     Fields:    Translation:AnimalsCells
  95. Allport JR, Muller WA, Luscinskas FW. Monocytes induce reversible focal changes in vascular endothelial cadherin complex during transendothelial migration under flow. J Cell Biol. 2000 Jan 10; 148(1):203-16. PMID: 10629229; PMCID: PMC2156206.
    Citations: 57     Fields:    Translation:HumansCells
  96. Xie H, Lim YC, Luscinskas FW, Lichtman AH. Acquisition of selectin binding and peripheral homing properties by CD4(+) and CD8(+) T cells. J Exp Med. 1999 Jun 07; 189(11):1765-76. PMID: 10359580; PMCID: PMC2193075.
    Citations: 37     Fields:    Translation:AnimalsCells
  97. Montoya MC, Holtmann K, Snapp KR, Borges E, Sánchez-Madrid F, Luscinskas FW, Kansas G, Vestweber D, de Landázuri MO. Memory B lymphocytes from secondary lymphoid organs interact with E-selectin through a novel glycoprotein ligand. J Clin Invest. 1999 May; 103(9):1317-27. PMID: 10225975; PMCID: PMC408468.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  98. Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA, Luster AD, Luscinskas FW, Rosenzweig A. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature. 1999 Apr 22; 398(6729):718-23. PMID: 10227295.
    Citations: 330     Fields:    Translation:HumansCells
  99. Lim YC, Henault L, Wagers AJ, Kansas GS, Luscinskas FW, Lichtman AH. Expression of functional selectin ligands on Th cells is differentially regulated by IL-12 and IL-4. J Immunol. 1999 Mar 15; 162(6):3193-201. PMID: 10092770.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  100. Tu L, Delahunty MD, Ding H, Luscinskas FW, Tedder TF. The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells. J Exp Med. 1999 Jan 18; 189(2):241-52. PMID: 9892607; PMCID: PMC2192992.
    Citations: 19     Fields:    Translation:HumansCells
  101. Kiely JM, Luscinskas FW, Gimbrone MA. Leukocyte-endothelial monolayer adhesion assay (static conditions). Methods Mol Biol. 1999; 96:131-6. PMID: 10098130.
    Citations: 6     Fields:    Translation:HumansCells
  102. Goetz DJ, Greif DM, Shen J, Luscinskas FW. Cell-cell adhesive interactions in an in vitro flow chamber. Methods Mol Biol. 1999; 96:137-45. PMID: 10098131.
    Citations: 3     Fields:    Translation:Humans
  103. Lim YC, Snapp K, Kansas GS, Camphausen R, Ding H, Luscinskas FW. Important contributions of P-selectin glycoprotein ligand-1-mediated secondary capture to human monocyte adhesion to P-selectin, E-selectin, and TNF-alpha-activated endothelium under flow in vitro. J Immunol. 1998 Sep 01; 161(5):2501-8. PMID: 9725249.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  104. Gerszten RE, Lim YC, Ding HT, Snapp K, Kansas G, Dichek DA, Cabañas C, Sánchez-Madrid F, Gimbrone MA, Rosenzweig A, Luscinskas FW. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: implications for atherogenesis. Circ Res. 1998 May 04; 82(8):871-8. PMID: 9580553.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  105. Allport JR, Ding H, Collins T, Gerritsen ME, Luscinskas FW. Endothelial-dependent mechanisms regulate leukocyte transmigration: a process involving the proteasome and disruption of the vascular endothelial-cadherin complex at endothelial cell-to-cell junctions. J Exp Med. 1997 Aug 18; 186(4):517-27. PMID: 9254650; PMCID: PMC2199034.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  106. Allport JR, Ding HT, Ager A, Steeber DA, Tedder TF, Luscinskas FW. L-selectin shedding does not regulate human neutrophil attachment, rolling, or transmigration across human vascular endothelium in vitro. J Immunol. 1997 May 01; 158(9):4365-72. PMID: 9127000.
    Citations: 28     Fields:    Translation:HumansCells
  107. Goetz DJ, Greif DM, Ding H, Camphausen RT, Howes S, Comess KM, Snapp KR, Kansas GS, Luscinskas FW. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. J Cell Biol. 1997 Apr 21; 137(2):509-19. PMID: 9128259; PMCID: PMC2139768.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  108. Lichtman AH, Ding H, Henault L, Vachino G, Camphausen R, Cumming D, Luscinskas FW. CD45RA-RO+ (memory) but not CD45RA+RO- (naive) T cells roll efficiently on E- and P-selectin and vascular cell adhesion molecule-1 under flow. J Immunol. 1997 Apr 15; 158(8):3640-50. PMID: 9103426.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  109. Gerszten RE, Luscinskas FW, Ding HT, Dichek DA, Stoolman LM, Gimbrone MA, Rosenzweig A. Adhesion of memory lymphocytes to vascular cell adhesion molecule-1-transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ Res. 1996 Dec; 79(6):1205-15. PMID: 8943959.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  110. Goetz DJ, Ding H, Atkinson WJ, Vachino G, Camphausen RT, Cumming DA, Luscinskas FW. A human colon carcinoma cell line exhibits adhesive interactions with P-selectin under fluid flow via a PSGL-1-independent mechanism. Am J Pathol. 1996 Nov; 149(5):1661-73. PMID: 8909255; PMCID: PMC1865285.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  111. Lichtman AH, Cybulsky M, Luscinskas FW. Immunology of atherosclerosis: the promise of mouse models. Am J Pathol. 1996 Aug; 149(2):351-7. PMID: 8701975; PMCID: PMC1865310.
    Citations: 5     Fields:    Translation:Animals
  112. Luscinskas FW, Ding H, Tan P, Cumming D, Tedder TF, Gerritsen ME. L- and P-selectins, but not CD49d (VLA-4) integrins, mediate monocyte initial attachment to TNF-alpha-activated vascular endothelium under flow in vitro. J Immunol. 1996 Jul 01; 157(1):326-35. PMID: 8683134.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  113. Pierce JW, Read MA, Ding H, Luscinskas FW, Collins T. Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration. J Immunol. 1996 May 15; 156(10):3961-9. PMID: 8621937.
    Citations: 69     Fields:    Translation:HumansCells
  114. Luscinskas FW, Gimbrone MA. Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment. Annu Rev Med. 1996; 47:413-21. PMID: 8712792.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  115. Kiely JM, Cybulsky MI, Luscinskas FW, Gimbrone MA. Immunoselective targeting of an anti-thrombin agent to the surface of cytokine-activated vascular endothelial cells. Arterioscler Thromb Vasc Biol. 1995 Aug; 15(8):1211-8. PMID: 7542999.
    Citations: 11     Fields:    Translation:HumansCells
  116. Gerritsen ME, Shen CP, McHugh MC, Atkinson WJ, Kiely JM, Milstone DS, Luscinskas FW, Gimbrone MA. Activation-dependent isolation and culture of murine pulmonary microvascular endothelium. Microcirculation. 1995 Aug; 2(2):151-63. PMID: 7497167.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  117. Read MA, Neish AS, Luscinskas FW, Palombella VJ, Maniatis T, Collins T. The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression. Immunity. 1995 May; 2(5):493-506. PMID: 7538441.
    Citations: 71     Fields:    Translation:HumansCells
  118. Luscinskas FW, Ding H, Lichtman AH. P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow. J Exp Med. 1995 Mar 01; 181(3):1179-86. PMID: 7532680; PMCID: PMC2191919.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  119. Luscinskas FW, Lawler J. Integrins as dynamic regulators of vascular function. FASEB J. 1994 Sep; 8(12):929-38. PMID: 7522194.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  120. Pizcueta P, Luscinskas FW. Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo. Am J Pathol. 1994 Aug; 145(2):461-9. PMID: 7519828; PMCID: PMC1887404.
    Citations: 15     Fields:    Translation:AnimalsCells
  121. Luscinskas FW, Kansas GS, Ding H, Pizcueta P, Schleiffenbaum BE, Tedder TF, Gimbrone MA. Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol. 1994 Jun; 125(6):1417-27. PMID: 7515891; PMCID: PMC2290931.
    Citations: 98     Fields:    Translation:HumansCells
  122. Shen J, Luscinskas FW, Gimbrone MA, Dewey CF. Fluid flow modulates vascular endothelial cytosolic calcium responses to adenine nucleotides. Microcirculation. 1994 Apr; 1(1):67-78. PMID: 8790579.
    Citations: 5     Fields:    Translation:AnimalsCells
  123. Ley K, Baker JB, Cybulsky MI, Gimbrone MA, Luscinskas FW. Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling. J Immunol. 1993 Dec 01; 151(11):6347-57. PMID: 7504019.
    Citations: 26     Fields:    Translation:AnimalsCells
  124. Shen J, Gimbrone MA, Luscinskas FW, Dewey CF. Regulation of adenine nucleotide concentration at endothelium-fluid interface by viscous shear flow. Biophys J. 1993 Apr; 64(4):1323-30. PMID: 8494987; PMCID: PMC1262450.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  125. Luscinskas FW, Kiely JM, Ding H, Obin MS, Hébert CA, Baker JB, Gimbrone MA. In vitro inhibitory effect of IL-8 and other chemoattractants on neutrophil-endothelial adhesive interactions. J Immunol. 1992 Sep 15; 149(6):2163-71. PMID: 1381398.
    Citations: 27     Fields:    Translation:HumansCells
  126. Spertini O, Luscinskas FW, Gimbrone MA, Tedder TF. Monocyte attachment to activated human vascular endothelium in vitro is mediated by leukocyte adhesion molecule-1 (L-selectin) under nonstatic conditions. J Exp Med. 1992 Jun 01; 175(6):1789-92. PMID: 1375271; PMCID: PMC2119244.
    Citations: 42     Fields:    Translation:HumansCells
  127. Schleimer RP, Sterbinsky SA, Kaiser J, Bickel CA, Klunk DA, Tomioka K, Newman W, Luscinskas FW, Gimbrone MA, McIntyre BW, Bochner BS. IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol. 1992 02 15; 148(4):1086-92. PMID: 1371130.
    Citations: 142     Fields:    Translation:HumansCells
  128. Shen J, Luscinskas FW, Connolly A, Dewey CF, Gimbrone MA. Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol. 1992 Feb; 262(2 Pt 1):C384-90. PMID: 1539628.
    Citations: 63     Fields:    Translation:AnimalsCells
  129. Denton MD, Marsden PA, Luscinskas FW, Brenner BM, Brady HR. Cytokine-induced phagocyte adhesion to human mesangial cells: role of CD11/CD18 integrins and ICAM-1. Am J Physiol. 1991 Dec; 261(6 Pt 2):F1071-9. PMID: 1721495.
    Citations: 13     Fields:    Translation:HumansCells
  130. Spertini O, Luscinskas FW, Kansas GS, Munro JM, Griffin JD, Gimbrone MA, Tedder TF. Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol. 1991 Oct 15; 147(8):2565-73. PMID: 1717567.
    Citations: 110     Fields:    Translation:HumansCells
  131. Bochner BS, Luscinskas FW, Gimbrone MA, Newman W, Sterbinsky SA, Derse-Anthony CP, Klunk D, Schleimer RP. Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med. 1991 Jun 01; 173(6):1553-7. PMID: 1709678; PMCID: PMC2190849.
    Citations: 128     Fields:    Translation:HumansCells
  132. Hébert CA, Luscinskas FW, Kiely JM, Luis EA, Darbonne WC, Bennett GL, Liu CC, Obin MS, Gimbrone MA, Baker JB. Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol. 1990 Nov 01; 145(9):3033-40. PMID: 2212672.
    Citations: 49     Fields:    Translation:HumansCells
  133. Nigam S, Fiore S, Luscinskas FW, Serhan CN. Lipoxin A4 and lipoxin B4 stimulate the release but not the oxygenation of arachidonic acid in human neutrophils: dissociation between lipid remodeling and adhesion. J Cell Physiol. 1990 Jun; 143(3):512-23. PMID: 2162850.
    Citations: 13     Fields:    Translation:HumansCells
  134. Luscinskas FW, Nicolaou KC, Webber SE, Veale CA, Gimbrone MA, Serhan CN. Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils. Biochem Pharmacol. 1990 Jan 15; 39(2):355-65. PMID: 2154229.
    Citations: 5     Fields:    Translation:HumansCells
  135. Luscinskas FW, Brock AF, Arnaout MA, Gimbrone MA. Endothelial-leukocyte adhesion molecule-1-dependent and leukocyte (CD11/CD18)-dependent mechanisms contribute to polymorphonuclear leukocyte adhesion to cytokine-activated human vascular endothelium. J Immunol. 1989 Apr 01; 142(7):2257-63. PMID: 2564407.
    Citations: 80     Fields:    Translation:HumansCells
  136. Wheeler ME, Luscinskas FW, Bevilacqua MP, Gimbrone MA. Cultured human endothelial cells stimulated with cytokines or endotoxin produce an inhibitor of leukocyte adhesion. J Clin Invest. 1988 Oct; 82(4):1211-8. PMID: 3049673; PMCID: PMC442671.
    Citations: 16     Fields:    Translation:HumansCells
  137. Newburger PE, Luscinskas FW, Ryan T, Beard CJ, Wright J, Platt OS, Simons ER, Tauber AI. Variant chronic granulomatous disease: modulation of the neutrophil defect by severe infection. Blood. 1986 Oct; 68(4):914-9. PMID: 3019454.
    Citations: 5     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.