Harvard Catalyst Profiles

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Markus H. Frank, M.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R24EY028767 (FRANK, NATASHA Y) Apr 1, 2018 - Jan 31, 2023
    NIH
    Multipotent ABCB5-positive cell therapeutics for corneal disease
    Role: Principal Investigator
  2. R01EY025794 (FRANK, MARKUS H.) Apr 1, 2016 - Mar 31, 2021
    NIH
    ABCB5-positive stem cells for LSCD therapy
    Role: Principal Investigator
  3. R01CA158467 (FRANK, MARKUS H.) Sep 1, 2012 - Jun 30, 2018
    NIH
    Immunology of human malignant melanoma initiating cells
    Role: Principal Investigator
  4. R01CA138231 (FRANK, MARKUS H.) Sep 24, 2008 - Jul 31, 2013
    NIH
    Melanoma Stem Cells, Vasculogenesis and Neoplastic Progression
    Role: Principal Investigator
  5. R01CA113796 (FRANK, MARKUS H.) Apr 14, 2006 - Feb 28, 2012
    NIH
    ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kiritsi D, Dieter K, Niebergall-Roth E, Fluhr S, Daniele C, Esterlechner J, Sadeghi S, Ballikaya S, Erdinger L, Schauer F, Gewert S, Laimer M, Bauer JW, Hovnanian A, Zambruno G, El Hachem M, Bourrat E, Papanikolaou M, Petrof G, Kitzmüller S, Ebens CL, Frank MH, Frank NY, Ganss C, Martinez AE, McGrath JA, Tolar J, Kluth MA. Clinical trial of ABCB5+ mesenchymal stem cells for recessive dystrophic epidermolysis bullosa. JCI Insight. 2021 11 22; 6(22). PMID: 34665781.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Singh K, Maity P, Koroma AK, Basu A, Pandey RK, Vander Beken S, Haas P, Krug L, Hainzl A, Sindrilaru A, Pfeiffer C, Wlaschek M, Frank NY, Frank MH, Ganss C, Bánvölgyi A, Wikonkál N, Eming S, Pastar I, Tomic-Canic M, Kluth MA, Scharffetter-Kochanek K. Angiogenin Released from ABCB5+ Stromal Precursors Improves Healing of Diabetic Wounds by Promoting Angiogenesis. J Invest Dermatol. 2022 Jun; 142(6):1725-1736.e10. PMID: 34808236.
    Citations:    Fields:    
  3. Kerstan A, Dieter K, Niebergall-Roth E, Dachtler AK, Kraft K, Stücker M, Daeschlein G, Jünger M, Görge T, Meyer-Pannwitt U, Erfurt-Berge C, von Engelhardt C, Klare A, Pfeiffer C, Esterlechner J, Schröder HM, Gasser M, Waaga-Gasser AM, Goebeler M, Ballikaya S, Sadeghi S, Murphy GF, Orgill DP, Frank NY, Ganss C, Scharffetter-Kochanek K, Frank MH, Kluth MA. Allogeneic ABCB5+ mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial. JID Innov. 2022 Jan; 2(1). PMID: 34870260.
    Citations: 1     
  4. Sasamoto Y, Lee CAA, Yoshihara M, Martin G, Ksander BR, Frank MH, Frank NY. High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells. Ocul Surf. 2022 01; 23:197-200. PMID: 34653711.
    Citations:    Fields:    Translation:HumansCells
  5. Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience. 2021 Jun 25; 24(6):102688. PMID: 34195566.
    Citations: 1     
  6. Norrick A, Esterlechner J, Niebergall-Roth E, Dehio U, Sadeghi S, Schröder HM, Ballikaya S, Stemler N, Ganss C, Dieter K, Dachtler AK, Merz P, Sel S, Chodosh J, Cursiefen C, Frank NY, Auffarth GU, Ksander B, Frank MH, Kluth MA. Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency. Stem Cell Res Ther. 2021 03 19; 12(1):194. PMID: 33741066.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Riedl J, Pickett-Leonard M, Eide C, Kluth MA, Ganss C, Frank NY, Frank MH, Ebens CL, Tolar J. ABCB5+ dermal mesenchymal stromal cells with favorable skin homing and local immunomodulation for recessive dystrophic epidermolysis bullosa treatment. Stem Cells. 2021 07; 39(7):897-903. PMID: 33609408.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Frank MH, Wilson BJ, Gold JS, Frank NY. Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted Therapies. Gastroenterology. 2021 05; 160(6):1947-1960. PMID: 33617889.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Ballikaya S, Sadeghi S, Niebergall-Roth E, Nimtz L, Frindert J, Norrick A, Stemler N, Bauer N, Rosche Y, Kratzenberg V, Pieper J, Ficek T, Frank MH, Ganss C, Esterlechner J, Kluth MA. Process data of allogeneic ex vivo-expanded ABCB5+ mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP. Stem Cell Res Ther. 2020 11 16; 11(1):482. PMID: 33198791.
    Citations: 5     Fields:    Translation:HumansCells
  10. Kerstan A, Niebergall-Roth E, Esterlechner J, Schröder HM, Gasser M, Waaga-Gasser AM, Goebeler M, Rak K, Schrüfer P, Endres S, Hagenbusch P, Kraft K, Dieter K, Ballikaya S, Stemler N, Sadeghi S, Tappenbeck N, Murphy GF, Orgill DP, Frank NY, Ganss C, Scharffetter-Kochanek K, Frank MH, Kluth MA. Ex vivo-expanded highly pure ABCB5+ mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data. Cytotherapy. 2021 02; 23(2):165-175. PMID: 33011075.
    Citations: 9     Fields:    Translation:HumansCells
  11. Lee CAA, Banerjee P, Wilson BJ, Wu S, Guo Q, Berg G, Karpova S, Mishra A, Lian JW, Tran J, Emmerich M, Murphy GF, Frank MH, Frank NY. Targeting the ABC transporter ABCB5 sensitizes glioblastoma to temozolomide-induced apoptosis through a cell-cycle checkpoint regulation mechanism. J Biol Chem. 2020 05 29; 295(22):7774-7788. PMID: 32317280.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  12. Li F, Yuan CW, Xu S, Zu T, Woappi Y, Lee CAA, Abarzua P, Wells M, Ramsey MR, Frank NY, Wu X, Mandinova A, Frank MH, Lian CG, Murphy GF. Loss of the Epigenetic Mark 5-hmC in Psoriasis: Implications for Epidermal Stem Cell Dysregulation. J Invest Dermatol. 2020 06; 140(6):1266-1275.e3. PMID: 31837302.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  13. Khattak MA, Reid A, Freeman J, Pereira M, McEvoy A, Lo J, Frank MH, Meniawy T, Didan A, Spencer I, Amanuel B, Millward M, Ziman M, Gray E. PD-L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study. Oncologist. 2020 03; 25(3):e520-e527. PMID: 32162809.
    Citations: 24     Fields:    Translation:HumansCells
  14. Khattak MA, Reid A, Freeman J, Pereira M, McEvoy A, Lo J, Frank MH, Meniawy T, Didan A, Spencer I, Amanuel B, Millward M, Ziman M, Gray E. PD-L1 Expression on Circulating Tumor Cells May Be Predictive of Response to Pembrolizumab in Advanced Melanoma: Results from a Pilot Study. Oncologist. 2019 Dec 05. PMID: 31806779.
    Citations: 1     Fields:    
  15. Sasamoto Y, Sasamoto N, Tran J, Mishra A, Ksander BR, Frank MH, Frank NY. Investigation of factors associated with ABCB5-positive limbal stem cell isolation yields from human donors. Ocul Surf. 2020 01; 18(1):114-120. PMID: 31655212.
    Citations: 3     Fields:    Translation:HumansCells
  16. Vander Beken S, de Vries JC, Meier-Schiesser B, Meyer P, Jiang D, Sindrilaru A, Ferreira FF, Hainzl A, Schatz S, Muschhammer J, Scheurmann NJ, Kampilafkos P, Seitz AM, Dürselen L, Ignatius A, Kluth MA, Ganss C, Wlaschek M, Singh K, Maity P, Frank NY, Frank MH, Scharffetter-Kochanek K. Newly Defined ATP-Binding Cassette Subfamily B Member 5 Positive Dermal Mesenchymal Stem Cells Promote Healing of Chronic Iron-Overload Wounds via Secretion of Interleukin-1 Receptor Antagonist. Stem Cells. 2019 08; 37(8):1057-1074. PMID: 31002437.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  17. Tappenbeck N, Schröder HM, Niebergall-Roth E, Hassinger F, Dehio U, Dieter K, Kraft K, Kerstan A, Esterlechner J, Frank NY, Scharffetter-Kochanek K, Murphy GF, Orgill DP, Beck J, Frank MH, Ganss C, Kluth MA. In vivo safety profile and biodistribution of GMP-manufactured human skin-derived ABCB5-positive mesenchymal stromal cells for use in clinical trials. Cytotherapy. 2019 05; 21(5):546-560. PMID: 30878384.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  18. Aya-Bonilla C, Gray ES, Manikandan J, Freeman JB, Zaenker P, Reid AL, Khattak MA, Frank MH, Millward M, Ziman M. Immunomagnetic-Enriched Subpopulations of Melanoma Circulating Tumour Cells (CTCs) Exhibit Distinct Transcriptome Profiles. Cancers (Basel). 2019 Jan 30; 11(2). PMID: 30769764.
    Citations: 7     
  19. Guo Q, Grimmig T, Gonzalez G, Giobbie-Hurder A, Berg G, Carr N, Wilson BJ, Banerjee P, Ma J, Gold JS, Nandi B, Huang Q, Waaga-Gasser AM, Lian CG, Murphy GF, Frank MH, Gasser M, Frank NY. ATP-binding cassette member B5 (ABCB5) promotes tumor cell invasiveness in human colorectal cancer. J Biol Chem. 2018 07 13; 293(28):11166-11178. PMID: 29789423.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  20. Sasamoto Y, Ksander BR, Frank MH, Frank NY. Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies. Expert Opin Biol Ther. 2018 05; 18(5):505-513. PMID: 29471701.
    Citations: 16     Fields:    Translation:HumansCells
  21. Gonzalez G, Sasamoto Y, Ksander BR, Frank MH, Frank NY. Limbal stem cells: identity, developmental origin, and therapeutic potential. Wiley Interdiscip Rev Dev Biol. 2018 03; 7(2). PMID: 29105366.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  22. Webber BR, O'Connor KT, McElmurry RT, Durgin EN, Eide CR, Lees CJ, Riddle MJ, Mathews WE, Frank NY, Kluth MA, Ganss C, Moriarity BS, Frank MH, Osborn MJ, Tolar J. Rapid generation of Col7a1-/- mouse model of recessive dystrophic epidermolysis bullosa and partial rescue via immunosuppressive dermal mesenchymal stem cells. Lab Invest. 2017 10; 97(10):1218-1224. PMID: 28892093.
    Citations: 11     Fields:    Translation:AnimalsCells
  23. Aya-Bonilla CA, Marsavela G, Freeman JB, Lomma C, Frank MH, Khattak MA, Meniawy TM, Millward M, Warkiani ME, Gray ES, Ziman M. Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device. Oncotarget. 2017 Sep 15; 8(40):67355-67368. PMID: 28978038.
    Citations: 26     Fields:    
  24. Aya-Bonilla CA, Marsavela G, Freeman JB, Lomma C, Frank MH, Khattak MA, Meniawy TM, Millward M, Warkiani ME, Gray ES, Ziman M. Isolation and detection of circulating tumour cells from metastatic melanoma patients using a slanted spiral microfluidic device. Oncotarget. 2017 Jun 27. PMID: 28700326.
    Citations:    
  25. Lutz NW, Banerjee P, Wilson BJ, Ma J, Cozzone PJ, Frank MH. Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line. PLoS One. 2016; 11(8):e0161803. PMID: 27560924.
    Citations: 5     Fields:    Translation:HumansCells
  26. Jiang D, Muschhammer J, Qi Y, Kügler A, de Vries JC, Saffarzadeh M, Sindrilaru A, Beken SV, Wlaschek M, Kluth MA, Ganss C, Frank NY, Frank MH, Preissner KT, Scharffetter-Kochanek K. Suppression of Neutrophil-Mediated Tissue Damage-A Novel Skill of Mesenchymal Stem Cells. Stem Cells. 2016 09; 34(9):2393-406. PMID: 27299700.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  27. Kleffel S, Lee N, Lezcano C, Wilson BJ, Sobolewski K, Saab KR, Mueller H, Zhan Q, Posch C, Elco CP, DoRosario A, Garcia SS, Thakuria M, Wang YE, Wang LC, Murphy GF, Frank MH, Schatton T. ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth. J Invest Dermatol. 2016 Apr; 136(4):838-846. PMID: 26827764.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Schatton T, Schütte U, Frank MH. Effects of Malignant Melanoma Initiating Cells on T-Cell Activation. Methods Mol Biol. 2016 Jan 20. PMID: 26786883.
    Citations: 1     Fields:    
  29. Ma J, Frank MH. Isolation of Circulating Melanoma Cells. Methods Mol Biol. 2015 Sep 29. PMID: 26415609.
    Citations: 4     Fields:    
  30. Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015 Sep 10; 162(6):1242-56. PMID: 26359984.
    Citations: 238     Fields:    Translation:HumansAnimalsCells
  31. Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, Sharpe AH, Waaga-Gasser AM, Sayegh MH, Abdi R, Scharffetter-Kochanek K, Murphy GF, Kupper TS, Frank NY, Frank MH. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Rep. 2015 Sep 08; 12(10):1564-74. PMID: 26321644.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  32. Gray ES, Reid AL, Bowyer S, Calapre L, Siew K, Pearce R, Cowell L, Frank MH, Millward M, Ziman M. Circulating Melanoma Cell Subpopulations: Their Heterogeneity and Differential Responses to Treatment. J Invest Dermatol. 2015 Aug; 135(8):2040-2048. PMID: 25830652.
    Citations: 38     Fields:    Translation:HumansCells
  33. de Waard NE, Kolovou PE, McGuire SP, Cao J, Frank NY, Frank MH, Jager MJ, Ksander BR. Expression of Multidrug Resistance Transporter ABCB5 in a Murine Model of Human Conjunctival Melanoma. Ocul Oncol Pathol. 2015 Apr; 1(3):182-189. PMID: 25960995.
    Citations: 5     
  34. Frank MH, Frank NY. Restoring the cornea from limbal stem cells. Regen Med. 2015; 10(1):1-4. PMID: 25562345.
    Citations: 10     Fields:    Translation:HumansCells
  35. Lee CW, Zhan Q, Lezcano C, Frank MH, Huang J, Larson AR, Lin JY, Wan MT, Lin PI, Ma J, Kleffel S, Schatton T, Lian CG, Murphy GF. Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest. 2014 Dec; 94(12):1382-95. PMID: 25365206.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Ksander BR, Kolovou PE, Wilson BJ, Saab KR, Guo Q, Ma J, McGuire SP, Gregory MS, Vincent WJ, Perez VL, Cruz-Guilloty F, Kao WW, Call MK, Tucker BA, Zhan Q, Murphy GF, Lathrop KL, Alt C, Mortensen LJ, Lin CP, Zieske JD, Frank MH, Frank NY. ABCB5 is a limbal stem cell gene required for corneal development and repair. Nature. 2014 Jul 17; 511(7509):353-7. PMID: 25030174.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  37. Wilson BJ, Saab KR, Ma J, Schatton T, Pütz P, Zhan Q, Murphy GF, Gasser M, Waaga-Gasser AM, Frank NY, Frank MH. ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. Cancer Res. 2014 Aug 01; 74(15):4196-207. PMID: 24934811.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  38. Volpicelli ER, Lezcano C, Zhan Q, Girouard SD, Kindelberger DW, Frank MH, Frank NY, Crum CP, Murphy GF. The multidrug-resistance transporter ABCB5 is expressed in human placenta. Int J Gynecol Pathol. 2014 Jan; 33(1):45-51. PMID: 24300535.
    Citations: 6     Fields:    Translation:HumansCells
  39. Murphy GF, Wilson BJ, Girouard SD, Frank NY, Frank MH. Stem cells and targeted approaches to melanoma cure. Mol Aspects Med. 2014 Oct; 39:33-49. PMID: 24145241.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  40. Lin JY, Zhang M, Schatton T, Wilson BJ, Alloo A, Ma J, Qureshi AA, Frank NY, Han J, Frank MH. Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Biochem Biophys Res Commun. 2013 Jul 05; 436(3):536-42. PMID: 23770371.
    Citations: 8     Fields:    Translation:HumansCells
  41. Reid AL, Millward M, Pearce R, Lee M, Frank MH, Ireland A, Monshizadeh L, Rai T, Heenan P, Medic S, Kumarasinghe P, Ziman M. Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression. Br J Dermatol. 2013 Jan; 168(1):85-92. PMID: 23013138.
    Citations: 37     Fields:    Translation:HumansCells
  42. Nedosekin DA, Sarimollaoglu M, Galanzha EI, Sawant R, Torchilin VP, Verkhusha VV, Ma J, Frank MH, Biris AS, Zharov VP. Synergy of photoacoustic and fluorescence flow cytometry of circulating cells with negative and positive contrasts. J Biophotonics. 2013 May; 6(5):425-34. PMID: 22903924.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  43. Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb; 132(2):410-20. PMID: 22158550.
    Citations: 27     Fields:    Translation:AnimalsCells
  44. Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res. 2011 Aug 01; 71(15):5307-16. PMID: 21652540.
    Citations: 60     Fields:    Translation:HumansAnimals
  45. Wilson BJ, Schatton T, Frank MH, Frank NY. Colorectal Cancer Stem Cells: Biology and Therapeutic Implications. Curr Colorectal Cancer Rep. 2011 Jun; 7(2):128-135. PMID: 21552371.
    Citations: 22     
  46. Ho J, Pandey P, Schatton T, Sims-Lucas S, Khalid M, Frank MH, Hartwig S, Kreidberg JA. The pro-apoptotic protein Bim is a microRNA target in kidney progenitors. J Am Soc Nephrol. 2011 Jun; 22(6):1053-63. PMID: 21546576.
    Citations: 58     Fields:    Translation:AnimalsCells
  47. Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF. SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011 Apr; 20(4):339-45. PMID: 21410764.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  48. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85. PMID: 21212411.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  49. Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Stephen Hodi F, Frank NY, Frank MH. Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun. 2010 Nov 26; 402(4):711-7. PMID: 20977885.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  50. Schatton T, Frank MH. The in vitro spheroid melanoma cell culture assay: cues on tumor initiation? J Invest Dermatol. 2010 Jul; 130(7):1769-71. PMID: 20548315.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  51. Izawa A, Schatton T, Frank NY, Ueno T, Yamaura K, Pendse SS, Margaryan A, Grimm M, Gasser M, Waaga-Gasser AM, Sayegh MH, Frank MH. A novel in vivo regulatory role of P-glycoprotein in alloimmunity. Biochem Biophys Res Commun. 2010 Apr 09; 394(3):646-52. PMID: 20230790.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Ma J, Frank MH. Tumor initiation in human malignant melanoma and potential cancer therapies. Anticancer Agents Med Chem. 2010 Feb; 10(2):131-6. PMID: 20184545.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  53. Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH. Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res. 2010 Jan 15; 70(2):697-708. PMID: 20068175.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  54. Frank NY, Schatton T, Frank MH. The therapeutic promise of the cancer stem cell concept. J Clin Invest. 2010 Jan; 120(1):41-50. PMID: 20051635.
    Citations: 291     Fields:    Translation:HumansAnimalsCells
  55. Frank MH, Sayegh MH. A gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof. 2009. View Publication.
  56. Schatton T, Frank NY, Frank MH. Identification and targeting of cancer stem cells. Bioessays. 2009 Oct; 31(10):1038-49. PMID: 19708024.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  57. Schatton T, Frank MH. Antitumor immunity and cancer stem cells. Ann N Y Acad Sci. 2009 Sep; 1176:154-69. PMID: 19796244.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  58. Frank NY, Frank MH. ABCB5 gene amplification in human leukemia cells. Leuk Res. 2009 Oct; 33(10):1303-5. PMID: 19477512.
    Citations: 8     Fields:    Translation:HumansCells
  59. Gasser M, Frank MH, Schatton T, Frank NY, Grimm MW, Fertinger J, Germer CT, Waaga-Gasser AM . Identifizierung tumorinitiierender Zellen im Pankreaskarzinom: Untersuchung zur Bedeutung des MDR-Gens ABCB5. 126. Kongress der Deutschen Gesellschaft für Chirurgie, 28.04. - 01.05.2009, München. 2009; DOI: 10.3205/09dgch095.
  60. Frank N, Schatton T, Kim S, Zhan Q, Hsu MY, Widlund H, Fuhlbrigge R, Kupper T, Murphy G, Frank M. Tumour-Promoting Vasculogenic Channels of Cancer Stem Cell Origin. 7th World Congress on Melanoma, May 12 -16 2009, Vienna, Austria. 2009; 191.
  61. Schatton T, Schütte U, Zhan Q, Hörning A, Murphy GF, Frank MH. Inhibition of T cell activation by melanoma stem cells. 7th World Congress on Melanoma, May 12 -16 2009, Vienna, Austria. 2009; 191-192.
  62. Ziman M, Millward M, Frank M, Pearce R, Medic S, Slattery R, Brown M, Lazic S, Lee M, Kumarasinghe P, Heenan P. Detection and Quantification of Circulating Melanoma Cells. 7th World Congress on Melanoma, May 12 -16 2009, Vienna, Austria. 2009; 123.
  63. Schatton T, Schütte U, Zhan Q, Hörning A, Murphy GF, Frank MH. Cancer stem cell-mediated immunomodulation in human malignant melanoma. Proceedings of the American Association for Cancer Research 100th Annual Meeting 2009, Denver, Colorado. 2009; 50(April 2009):765 (Abstract #3164).
  64. Frank NY, Schatton T, Kim S, Zhan Q, Hsu MY, Widlund HR, Fuhlbrigge RC, Kupper TS, Murphy GF, Frank MH. Melanoma vasculogenesis driven by cancer stem cells. Proceedings of the American Association for Cancer Research 100th Annual Meeting 2009, Denver, Colorado. 2009; 50(April 2009):759 (Abstract #3131).
  65. Schatton T, Frank NY, Frank MH. Solid tumor stem cells – implications for cancer therapy. Regulatory Networks in Stem Cells. 2009.
  66. Schatton T, Frank NY, Frank MH. Solid tumor stem cells – implications for cancer therapy. Regulatory Networks in Stem Cells (V.K. Rajasekhar and M.C. Vemuri, Editors.). 2009; 527-543.
  67. Behjati S, Frank MH. The effects of tamoxifen on immunity. Curr Med Chem. 2009; 16(24):3076-80. PMID: 19689284.
    Citations: 39     Fields:    Translation:HumansCells
  68. Frank MH, Sayegh MH. Gene encoding a multidrug-resistance human P-glycoprotein homologue on chromosome 7p15-2 and uses thereof. 2008. View Publication.
  69. Frank MH, Sayegh MH. Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof. 2008.
  70. Frank MH, Frank NY. Therapeutic and diagnostic methods relating to cancer stem cells. 2008.
  71. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. International Investigative Dermatology 2008 Meeting. 2008; Kyoto, Japan May 14-17 2008.
  72. Schatton S, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. AACR Annual Meeting 2008. 2008; San Diego, CA, USA April 12-16.
  73. Schatton T, Frank MH. Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res. 2008 Feb; 21(1):39-55. PMID: 18353142.
    Citations: 88     Fields:    Translation:HumansCells
  74. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9. PMID: 18202660.
    Citations: 560     Fields:    Translation:HumansAnimalsCells
  75. Frank MH. ABCB5 positive mesenchymal stem cells as immunomodulators. 2007. View Publication.
  76. Frank MH, Frank NY, Sayegh MH. Targeting ABCB5 for cancer therapy. 2007. View Publication.
  77. Pendse SS, Behjati S, Schatton T, Izawa A, Sayegh MH, Frank MH. P-glycoprotein functions as a differentiation switch in antigen presenting cell maturation. Am J Transplant. 2006 Dec; 6(12):2884-93. PMID: 17083370.
    Citations: 15     Fields:    Translation:HumansCells
  78. Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. PMID: 17015616.
    Citations: 33     Fields:    Translation:HumansCells
  79. Lutz NW, Franks SE, Frank MH, Pomer S, Hull WE. Investigation of multidrug resistance in cultured human renal cell carcinoma cells by 31P-NMR spectroscopy and treatment survival assays. MAGMA. 2005 Jul; 18(3):144-61. PMID: 15977034.
    Citations: 2     Fields:    Translation:HumansCells
  80. Frank NY, Margaryan A, Huang Y, Schatton T, Waaga-Gasser AM, Gasser M, Sayegh MH, Sadee W, Frank MH. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005 May 15; 65(10):4320-33. PMID: 15899824.
    Citations: 209     Fields:    Translation:HumansCells
  81. Frank MH, Sayegh MH. A gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7p15-21 and uses thereof. 2005. View Publication.
  82. Lapchak PH, Melter M, Pal S, Flaxenburg JA, Geehan C, Frank MH, Mukhopadhyay D, Briscoe DM. CD40-induced transcriptional activation of vascular endothelial growth factor involves a 68-bp region of the promoter containing a CpG island. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F512-20. PMID: 15140761.
    Citations: 7     Fields:    Translation:HumansCells
  83. Frank MH, Sayegh MH. Immunomodulatory functions of mesenchymal stem cells. Lancet. 2004 May 01; 363(9419):1411-2. PMID: 15121399.
    Citations: 27     Fields:    Translation:HumansCells
  84. Frank NY, Pendse SS, Lapchak PH, Margaryan A, Shlain D, Doeing C, Sayegh MH, Frank MH. Regulation of progenitor cell fusion by ABCB5 P-glycoprotein, a novel human ATP-binding cassette transporter. J Biol Chem. 2003 Nov 21; 278(47):47156-65. PMID: 12960149.
    Citations: 95     Fields:    Translation:HumansCells
  85. Pendse S, Sayegh MH, Frank MH. P-glycoprotein--a novel therapeutic target for immunomodulation in clinical transplantation and autoimmunity? Curr Drug Targets. 2003 Aug; 4(6):469-76. PMID: 12866661.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  86. Pendse SS, Briscoe DM, Frank MH. P-glycoprotein and alloimmune T-cell activation. Clin Appl Immunol Rev. 2003 Jul; 4(1):3-14. PMID: 21709754.
    Citations: 3     
  87. Frank MH, Denton MD, Alexander SI, Khoury SJ, Sayegh MH, Briscoe DM. Specific MDR1 P-glycoprotein blockade inhibits human alloimmune T cell activation in vitro. J Immunol. 2001 Feb 15; 166(4):2451-9. PMID: 11160305.
    Citations: 22     Fields:    Translation:HumansCells
  88. Frank MH. Briscoe DM. Monoclonal Antibody Targeting of Adhesion Molecules. Current and Future Immunosuppressive Therapies Following Transplantation. 2001; 249-263.
  89. Frank MH, Sayegh MH. Tolerance: is it time to move to the clinic?. Current and Future Immunosuppressive Therapies Following Transplantation. 2001; 293-313.
  90. Frank MH, Pomer S. Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype. J Cancer Res Clin Oncol. 1999; 125(2):117-20. PMID: 10190320.
    Citations: 3     Fields:    Translation:HumansCells
  91. Kellner H, Liegl U, Frank M, Zoller WG. [Reversible esophageal dysfunction as a side effect of levodopa]. Bildgebung. 1996 Mar; 63(1):48-50. PMID: 8653009.
    Citations: 1     Fields:    Translation:Humans
  92. Frank MH. 31P-NMR-spektroskopische Studien zur Multidrug-Resistenz des menschlichen Nierenzellkarzinoms [Doctoral Dissertation]. 1995.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.