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Hacohen, Nir
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Nir Hacohen, Ph.D.
Title
Professor of Medicine
Institution
Massachusetts General Hospital
Department
Medicine
Address
Massachusetts General Hospital
149-7th floor, Cancer Center
149 13th Street
Charlestown MA 02129
Phone
617/724-3768
Fax
617/726-5651
vCard
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completed student projects
|
research activities and funding
|
selected publications
|
Mentoring
completed student projects
In vitro validation of immune resistant genetic changes in cancer
Summer, 06/05/15 - 08/15/15
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01AI158495
(HACOHEN, NIR)
Sep 17, 2021 - Aug 31, 2026
NIH
Factors regulating strength and duration of STING signaling
Role: Principal Investigator
R01AI153142
(GOLDBERG, MARCIA B)
Mar 3, 2021 - Feb 28, 2026
NIH
Single-cell genomic profiling to identify immune signatures of bacterial sepsis in humans
Role: Co-Principal Investigator
R56AI137244
(MERAD, MIRIAM)
Sep 1, 2018 - Aug 31, 2021
NIH
The Immune Cell Atlas â A Robust Framework to Map the Entire Human Immune System
Role: Co-Principal Investigator
UH3DK114907
(KRETZLER, MATTHIAS)
Sep 15, 2017 - Jun 30, 2022
NIH
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)
Role: Co-Principal Investigator
UG3DK114907
(KRETZLER, MATTHIAS)
Sep 15, 2017 - Jun 30, 2019
NIH
PREcision Medicine through IntErrogation of Rna in the kidnEy (PREMIERE)
Role: Co-Principal Investigator
R01CA208756
(HACOHEN, NIR)
Aug 26, 2016 - Jul 31, 2021
NIH
(PQ3) The role of damaged DNA in inter-individual variation of tumor immunity
Role: Principal Investigator
U24AI118668
(HACOHEN, NIR)
Jun 26, 2015 - May 31, 2021
NIH
Low-input multiplex isolation and profiling of human immune cell subsets using an integrated microfluidics device
Role: Principal Investigator
R01HG008131
(HACOHEN, NIR)
Apr 15, 2015 - Mar 31, 2019
NIH
Non-coding genetic variants that impact immune phenotypes and diseases
Role: Principal Investigator
RM1HG006193
(HACOHEN, NIR)
Jul 9, 2011 - Apr 30, 2021
NIH
Center for Cell Circuits
Role: Principal Investigator
S10RR026688
(HACOHEN, NIR)
Nov 20, 2009 - Nov 19, 2010
NIH
nCounter Analysis System
Role: Principal Investigator
DP2OD002230
(HACOHEN, NIR)
Sep 30, 2007 - Aug 31, 2012
NIH
Revealing pathogen-sensing pathways using RNAi libraries
Role: Principal Investigator
R21AI071060
(HACOHEN, NIR)
Jul 15, 2006 - Jun 30, 2008
NIH
Genetic dissection of dendritic cells using RNAi libraries
Role: Principal Investigator
R21AI063081
(HACOHEN, NIR)
Mar 15, 2005 - Feb 28, 2008
NIH
Synthetic oligosaccharides for dendritic cell targeting
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Sun Y,
Revach OY
, Anderson S, Kessler EA, Wolfe CH, Jenney A,
Mills CE
, Robitschek EJ, Davis TGR, Kim S, Fu A,
Ma X
, Gwee J, Tiwari P, Du PP, Sindurakar P,
Tian J
,
Mehta A
, Schneider AM, Yizhak K,
Sade-Feldman M
, LaSalle T, Sharova T,
Xie H
, Liu S, Michaud WA, Saad-Beretta R, Yates KB, Iracheta-Vellve A,
Spetz JKE
,
Qin X
,
Sarosiek KA
, Zhang G, Kim JW, Su MY, Cicerchia AM, Rasmussen MQ,
Klempner SJ
,
Juric D
,
Pai SI
, Miller DM, Giobbie-Hurder A,
Chen JH
, Pelka K, Frederick DT, Stinson S,
Ivanova E
, Aref AR,
Paweletz CP
,
Barbie DA
,
Sen DR
,
Fisher DE
,
Corcoran RB
,
Hacohen N
,
Sorger PK
,
Flaherty KT
,
Boland GM
,
Manguso RT
,
Jenkins RW
. Targeting TBK1 to overcome resistance to cancer immunotherapy. Nature. 2023 Jan 12.
PMID:
36634707
.
Citations:
Fields:
Sci
Science
Cohn O
, Yankovitz G, Peshes-Yaloz N, Steuerman Y, Frishberg A, Brandes R, Mandelboim M, Hamilton JR, Hagai T, Amit I, Netea MG,
Hacohen N
, Iraqi FA, Bacharach E, Gat-Viks I. Distinct gene programs underpinning disease tolerance and resistance in influenza virus infection. Cell Syst. 2022 Dec 21; 13(12):1002-1015.e9.
PMID:
36516834
.
Citations:
Fields:
Cel
Cell Biology
Com
Computational Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
LaSalle TJ, Gonye ALK, Freeman SS,
Kaplonek P
, Gushterova I, Kays KR, Manakongtreecheep K, Tantivit J,
Rojas-Lopez M
, Russo BC, Sharma N, Thomas MF, Lavin-Parsons KM, Lilly BM, Mckaig BN, Charland NC, Khanna HK, Lodenstein CL, Margolin JD, Blaum EM, Lirofonis PB,
Revach OY
,
Mehta A
,
Sonny A
,
Bhattacharyya RP
, Parry BA,
Goldberg MB
,
Alter G
,
Filbin MR
,
Villani AC
,
Hacohen N
,
Sade-Feldman M
. Longitudinal characterization of circulating neutrophils uncovers phenotypes associated with severity in hospitalized COVID-19 patients. Cell Rep Med. 2022 10 18; 3(10):100779.
PMID:
36208629
; PMCID:
PMC9510054
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Dubrot J, Du PP, Lane-Reticker SK, Kessler EA, Muscato AJ,
Mehta A
, Freeman SS, Allen PM, Olander KE, Ockerman KM, Wolfe CH, Wiesmann F, Knudsen NH,
Tsao HW
, Iracheta-Vellve A, Schneider EM, Rivera-Rosario AN, Kohnle IC, Pope HW, Ayer A, Mishra G, Zimmer MD, Kim SY, Mahapatra A, Ebrahimi-Nik H, Frederick DT,
Boland GM
, Haining WN, Root DE, Doench JG,
Hacohen N
, Yates KB,
Manguso RT
. In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nat Immunol. 2022 10; 23(10):1495-1506.
PMID:
36151395
.
Citations:
1
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
Wang C, Li Y,
Kaplonek P
, Gentili M, Fischinger S,
Bowman KA
,
Sade-Feldman M
, Kays KR, Regan J, Flynn JP,
Goldberg MB
,
Hacohen N
,
Filbin MR
, Lauffenburger DA,
Alter G
,
Li JZ
. The Kinetics of SARS-CoV-2 Antibody Development Is Associated with Clearance of RNAemia. mBio. 2022 08 30; 13(4):e0157722.
PMID:
35762593
; PMCID:
PMC9426503
.
Citations:
Fields:
Mic
Microbiology
Dahlqvist J, Fulco CP, Ray JP, Liechti T, de Boer CG, Lieb DJ, Eisenhaure TM, Engreitz JM, Roederer M,
Hacohen N
. Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease. Hum Mol Genet. 2022 06 22; 31(12):1946-1961.
PMID:
34970970
; PMCID:
PMC9239749
.
Citations:
Fields:
Gen
Genetics
Mol
Molecular Biology
Translation:
Humans
Cells
Leisman DE
,
Mehta A
, Thompson BT,
Hacohen N
,
Filbin MR
,
Goldberg MB
. Reply to Akin et al.: High Renin Concentrations in Severe COVID-19 Are Indicative for a Hypo-Renin-Angiotensin-System State. Am J Respir Crit Care Med. 2022 05 15; 205(10):1253-1254.
PMID:
35348420
; PMCID:
PMC9872805
.
Citations:
Fields:
Cri
Critical Care
Pul
Pulmonary Medicine
Translation:
Humans
Cells
Mouri K, Guo MH, de Boer CG, Lissner MM, Harten IA, Newby GA, DeBerg HA, Platt WF, Gentili M, Liu DR, Campbell DJ,
Hacohen N
, Tewhey R, Ray JP. Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells. Nat Genet. 2022 05; 54(5):603-612.
PMID:
35513721
; PMCID:
PMC9793778
.
Citations:
Fields:
Gen
Genetics
Translation:
Animals
Cells
Oliveira G
, Stromhaug K,
Cieri N
,
Iorgulescu JB
, Klaeger S, Wolff JO, Rachimi S, Chea V,
Krause K
, Freeman SS, Zhang W, Li S, Braun DA,
Neuberg D
, Carr SA, Livak KJ, Frederick DT,
Fritsch EF
, Wind-Rotolo M,
Hacohen N
,
Sade-Feldman M
,
Yoon CH
,
Keskin DB
,
Ott PA
,
Rodig SJ
,
Boland GM
,
Wu CJ
. Landscape of helper and regulatory antitumour CD4+ T cells in melanoma. Nature. 2022 05; 605(7910):532-538.
PMID:
35508657
; PMCID:
PMC9815755
.
Citations:
1
Fields:
Sci
Science
Translation:
Humans
Cells
Fava A, Rao DA, Mohan C, Zhang T, Rosenberg A, Fenaroli P, Belmont HM, Izmirly P, Clancy R, Trujillo JM, Fine D, Arazi A, Berthier CC, Davidson A, James JA, Diamond B,
Hacohen N
, Wofsy D,
Raychaudhuri S
, Apruzzese W, Buyon J, Petri M. Urine Proteomics and Renal Single-Cell Transcriptomics Implicate Interleukin-16 in Lupus Nephritis. Arthritis Rheumatol. 2022 05; 74(5):829-839.
PMID:
34783463
; PMCID:
PMC9050800
.
Citations:
2
Fields:
Rhe
Rheumatology
Translation:
Humans
Cells
Leisman DE
,
Mehta A
,
Thompson BT
, Charland NC, Gonye ALK, Gushterova I, Kays KR, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF, Parry BA,
Villani AC
,
Sade-Feldman M
,
Hacohen N
,
Filbin MR
,
Goldberg MB
. Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19. Am J Respir Crit Care Med. 2022 03 01; 205(5):507-519.
PMID:
34878969
; PMCID:
PMC8906476
.
Citations:
5
Fields:
Cri
Critical Care
Pul
Pulmonary Medicine
Translation:
Humans
Cells
Freeman SS,
Sade-Feldman M
, Kim J, Stewart C, Gonye ALK,
Ravi A
, Arniella MB, Gushterova I, LaSalle TJ, Blaum EM, Yizhak K, Frederick DT, Sharova T, Leshchiner I, Elagina L, Spiro OG, Livitz D, Rosebrock D, Aguet F, Carrot-Zhang J, Ha G, Lin Z,
Chen JH
, Barzily-Rokni M, Hammond MR, Vitzthum von Eckstaedt HC, Blackmon SM, Jiao YJ, Gabriel S, Lawrence DP,
Duncan LM
,
Stemmer-Rachamimov AO
, Wargo JA,
Flaherty KT
, Sullivan RJ,
Boland GM
,
Meyerson M
,
Getz G
,
Hacohen N
. Combined tumor and immune signals from genomes or transcriptomes predict outcomes of checkpoint inhibition in melanoma. Cell Rep Med. 2022 02 15; 3(2):100500.
PMID:
35243413
; PMCID:
PMC8861826
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Chao S, Brenner MP,
Hacohen N
. Identifying Cell Type-Specific Chemokine Correlates with Hierarchical Signal Extraction from Single-Cell Transcriptomes. Pac Symp Biocomput. 2022; 27:254-265.
PMID:
34890154
.
Citations:
Fields:
Com
Computational Biology
Translation:
Humans
Cells
Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M,
Chen JH
, Sarkizova S, Ng K,
Giannakis M
,
Boland GM
,
Aguirre AJ
,
Anderson AC
, Rozenblatt-Rosen O, Regev A,
Hacohen N
, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS. Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell. 2021 12 22; 184(26):6262-6280.e26.
PMID:
34910928
; PMCID:
PMC8941949
.
Citations:
11
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Maciag K, Raychowdhury R, Smith K, Schneider AM, Coers J, Mumbach MR, Schwartz S,
Hacohen N
. IRF3 inhibits IFN-?-mediated restriction of intracellular pathogens in macrophages independently of IFNAR. J Leukoc Biol. 2022 08; 112(2):257-271.
PMID:
34826345
; PMCID:
PMC9550582
.
Citations:
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Wang C, Cui A, Bukenya M, Aung A, Pradhan D, Whittaker CA, Agarwal Y, Thomas A, Liang S, Amlashi P, Suh H, Spranger S,
Hacohen N
, Irvine DJ. Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade. Cell Rep. 2021 11 23; 37(8):110021.
PMID:
34818534
; PMCID:
PMC8653865
.
Citations:
2
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Parikh AR
, Szabolcs A, Allen JN,
Clark JW
,
Wo JY
, Raabe M, Thel H, Hoyos D,
Mehta A
, Arshad S, Lieb DJ, Drapek LC,
Blaszkowsky LS
, Giantonio BJ,
Weekes CD
, Zhu AX,
Goyal L
,
Nipp RD
, Dubois JS, Van Seventer EE, Foreman BE, Matlack LE, Ly L, Meurer JA,
Hacohen N
,
Ryan DP
,
Yeap BY
,
Corcoran RB
, Greenbaum BD, Ting DT,
Hong TS
. Radiation therapy enhances immunotherapy response in microsatellite stable colorectal and pancreatic adenocarcinoma in a phase II trial. Nat Cancer. 2021 11; 2(11):1124-1135.
PMID:
35122060
; PMCID:
PMC8809884
.
Citations:
9
Translation:
Humans
Cells
CT
Clinical Trials
Raychowdhury R, Gentili M, Cui A, Schweitzer LD, Li B,
Hacohen N
. Macrophages from Rosa26-Integrated Cas9-Expressing C57BL/6J Mice Have a Putative TRIF-Mediated Defect in the TLR-3/4 Signaling. Immunohorizons. 2021 10 19; 5(10):818-829.
PMID:
34667099
.
Citations:
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Ouspenskaia T, Law T, Clauser KR, Klaeger S, Sarkizova S, Aguet F, Li B, Christian E, Knisbacher BA, Le PM, Hartigan CR, Keshishian H, Apffel A,
Oliveira G
, Zhang W, Chen S, Chow YT, Ji Z, Jungreis I, Shukla SA, Justesen S, Bachireddy P, Kellis M,
Getz G
,
Hacohen N
,
Keskin DB
, Carr SA,
Wu CJ
, Regev A. Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer. Nat Biotechnol. 2022 02; 40(2):209-217.
PMID:
34663921
.
Citations:
11
Fields:
Bio
Biotechnology
Translation:
Humans
Fenyves BG,
Mehta A
, Kays KR, Beakes C, Margolin J,
Goldberg MB
,
Hacohen N
,
Filbin MR
. Plasma P-selectin is an early marker of thromboembolism in COVID-19. Am J Hematol. 2021 12 01; 96(12):E468-E471.
PMID:
34622480
.
Citations:
2
Fields:
Hem
Hematology
Translation:
Humans
Cells
Kaplonek P
, Wang C,
Bartsch Y
, Fischinger S,
Gorman MJ
, Bowman K, Kang J, Dayal D, Martin P,
Nowak RP
,
Villani AC
, Hsieh CL, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF,
Sade-Feldman M
, Feldman J, Julg B,
Nilles EJ
, Musk ER, Menon AS,
Fischer ES
, McLellan JS,
Schmidt A
,
Goldberg MB
,
Filbin MR
,
Hacohen N
, Lauffenburger DA,
Alter G
. Early cross-coronavirus reactive signatures of humoral immunity against COVID-19. Sci Immunol. 2021 Oct 15; 6(64):eabj2901.
PMID:
34652962
; PMCID:
PMC8943686
.
Citations:
23
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
LaSalle TJ, Gonye ALK, Freeman SS,
Kaplonek P
, Gushterova I, Kays KR, Manakongtreecheep K, Tantivit J,
Rojas-Lopez M
, Russo BC, Sharma N, Thomas MF, Lavin-Parsons KM, Lilly BM, Mckaig BN, Charland NC, Khanna HK, Lodenstein CL, Margolin JD, Blaum EM, Lirofonis PB,
Sonny A
,
Bhattacharyya RP
, Parry BA,
Goldberg MB
,
Alter G
,
Filbin MR
,
Villani AC
,
Hacohen N
,
Sade-Feldman M
. Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with disease severity in hospitalized COVID-19 patients. bioRxiv. 2021 Oct 05.
PMID:
34642692
; PMCID:
PMC8509090
.
Citations:
1
Ward RA, Aghaeepour N,
Bhattacharyya RP
, Clish CB, Gaudillière B,
Hacohen N
,
Mansour MK
, Mudd PA, Pasupneti S, Presti RM,
Rhee EP
,
Sen P
, Spec A,
Tam JM
,
Villani AC
,
Woolley AE
, Hsu JL,
Vyas JM
. Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease. Open Forum Infect Dis. 2021 Nov; 8(11):ofab483.
PMID:
34805429
; PMCID:
PMC8598922
.
Citations:
Chen X, Gentili M,
Hacohen N
, Regev A. A cell-free nanobody engineering platform rapidly generates SARS-CoV-2 neutralizing nanobodies. Nat Commun. 2021 09 17; 12(1):5506.
PMID:
34535642
; PMCID:
PMC8448731
.
Citations:
8
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Pelka K, Hofree M,
Chen JH
, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, Hoang ML, Delorey T, Nguyen LT, Waldman J, Klapholz M, Wakiro I,
Cohen O
, Albers J,
Smillie CS
, Cuoco MS, Wu J, Su MJ, Yeung J, Vijaykumar B, Magnuson AM, Asinovski N, Moll T, Goder-Reiser MN, Applebaum AS, Brais LK, DelloStritto LK, Denning SL, Phillips ST, Hill EK, Meehan JK, Frederick DT, Sharova T, Kanodia A, Todres EZ, Jané-Valbuena J, Biton M, Izar B, Lambden CD,
Clancy TE
,
Bleday R
,
Melnitchouk N
,
Irani J
,
Kunitake H
,
Berger DL
,
Srivastava A
,
Hornick JL
,
Ogino S
,
Rotem A
, Vigneau S,
Johnson BE
,
Corcoran RB
,
Sharpe AH
,
Kuchroo VK
,
Ng K
,
Giannakis M
, Nieman LT,
Boland GM
,
Aguirre AJ
,
Anderson AC
, Rozenblatt-Rosen O, Regev A,
Hacohen N
. Spatially organized multicellular immune hubs in human colorectal cancer. Cell. 2021 09 02; 184(18):4734-4752.e20.
PMID:
34450029
; PMCID:
PMC8772395
.
Citations:
24
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Klaeger S, Apffel A, Clauser KR, Sarkizova S,
Oliveira G
, Rachimi S, Le PM, Tarren A, Chea V, Abelin JG, Braun DA,
Ott PA
, Keshishian H,
Hacohen N
,
Keskin DB
,
Wu CJ
, Carr SA. Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples. Mol Cell Proteomics. 2021; 20:100133.
PMID:
34391888
; PMCID:
PMC8724927
.
Citations:
2
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Tonnerre P, Wolski D,
Subudhi S
, Aljabban J, Hoogeveen RC, Damasio M,
Drescher HK
,
Bartsch LM
, Tully DC,
Sen DR
, Bean DJ, Brown J, Torres-Cornejo A, Robidoux M, Kvistad D,
Alatrakchi N
, Cui A, Lieb D, Cheney JA, Gustafson J, Lewis-Ximenez LL, Massenet-Regad L, Eisenhaure T, Aneja J, Haining WN,
Chung RT
,
Hacohen N
,
Allen TM
,
Kim AY
,
Lauer GM
. Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory. Nat Immunol. 2021 08; 22(8):1030-1041.
PMID:
34312544
; PMCID:
PMC8323980
.
Citations:
8
Fields:
All
Allergy and Immunology
Translation:
Humans
Cells
Oliveira G
, Stromhaug K, Klaeger S,
Kula T
, Frederick DT, Le PM, Forman J, Huang T, Li S, Zhang W, Xu Q,
Cieri N
, Clauser KR, Shukla SA,
Neuberg D
, Justesen S, MacBeath G, Carr SA,
Fritsch EF
,
Hacohen N
,
Sade-Feldman M
, Livak KJ,
Boland GM
,
Ott PA
,
Keskin DB
,
Wu CJ
. Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma. Nature. 2021 08; 596(7870):119-125.
PMID:
34290406
; PMCID:
PMC9187974
.
Citations:
34
Fields:
Sci
Science
Translation:
Humans
Cells
Lemieux JE
, Li A, Gentili M,
Perugino CA
, Weiss ZF,
Bowman K
,
Ankomah P
, Liu H,
Lewis GD
, Bitar N, Lipiner T,
Hacohen N
,
Pillai SS
,
Goldberg MB
. Vaccine serologic responses among transplant patients associate with COVID-19 infection and T peripheral helper cells. medRxiv. 2021 Jul 14.
PMID:
34282426
; PMCID:
PMC8288159
.
Citations:
1
Fenyves BG,
Mehta A
, Kays KR,
Goldberg MB
,
Hacohen N
,
Filbin MR
. Plasma P-selectin is an early marker of thromboembolism in COVID-19. medRxiv. 2021 Jul 14.
PMID:
34282425
.
Citations:
Li Y, Schneider AM,
Mehta A
,
Sade-Feldman M
, Kays KR, Gentili M, Charland NC, Gonye AL, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Parry BA,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF, Regan J, Flynn JP,
Villani AC
,
Hacohen N
,
Goldberg MB
,
Filbin MR
,
Li JZ
. SARS-CoV-2 viremia is associated with distinct proteomic pathways and predicts COVID-19 outcomes. J Clin Invest. 2021 07 01; 131(13).
PMID:
34196300
; PMCID:
PMC8245177
.
Citations:
25
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
PH
Public Health
Reyes M,
Filbin MR
,
Bhattacharyya RP
,
Sonny A
,
Mehta A
, Billman K, Kays KR, Pinilla-Vera M, Benson ME,
Cosimi LA
,
Hung DT
, Levy BD,
Villani AC
,
Sade-Feldman M
,
Baron RM
,
Goldberg MB
, Blainey PC,
Hacohen N
. Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro. Sci Transl Med. 2021 06 16; 13(598).
PMID:
34103408
; PMCID:
PMC8432955
.
Citations:
15
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY,
Gallagher KME
, Bauer MR, Taylor HB, Dunn WA, Tarr C, Sidney J, Rachimi S, Conway HL, Katsis K, Wang Y, Leistritz-Edwards D, Durkin MR, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD, Carulli IP, Chea VA, Chandrashekar A, Bozkus CC, Carrington M, Bhardwaj N,
Barouch DH
, Sette A,
Maus MV
, Rice CM, Clauser KR,
Keskin DB
, Pregibon DC,
Hacohen N
, Carr SA, Abelin JG, Saeed M,
Sabeti PC
. Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs. Cell. 2021 07 22; 184(15):3962-3980.e17.
PMID:
34171305
; PMCID:
PMC8173604
.
Citations:
15
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Kaplonek P
, Wang C,
Bartsch Y
, Fischinger S,
Gorman MJ
,
Bowman K
, Kang J, Dayal D, Martin P, Nowak R, Hsieh CL, Feldman J, Julg B,
Nilles EJ
, Musk ER, Menon AS,
Fischer ES
, McLellan JS,
Schmidt A
,
Goldberg MB
,
Filbin M
,
Hacohen N
, Lauffenburger DA,
Alter G
. Early cross-coronavirus reactive signatures of protective humoral immunity against COVID-19. bioRxiv. 2021 May 12.
PMID:
34013263
.
Citations:
1
Filbin MR
,
Mehta A
, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF,
Gerszten RE
, Heimberg GS,
Hoover PJ
, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M,
Smillie CS
,
Waghray A
,
Wood TE
, Zajac AS, Jennings LL, Grundberg I,
Bhattacharyya RP
, Parry BA,
Villani AC
,
Sade-Feldman M
,
Hacohen N
,
Goldberg MB
. Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions. Cell Rep Med. 2021 05 18; 2(5):100287.
PMID:
33969320
; PMCID:
PMC8091031
.
Citations:
38
Fields:
Med
Medicine (General)
Delorey TM, Ziegler CGK, Heimberg G,
Normand R
, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ,
Subramanian A
, Montoro DT,
Jagadeesh KA
,
Dey KK
,
Sen P
, Slyper M, Pita-Juárez YH, Phillips D, Biermann J,
Bloom-Ackermann Z
, Barkas N,
Ganna A
,
Gomez J
, Melms JC,
Katsyv I
, Normandin E,
Naderi P
,
Popov YV
, Raju SS, Niezen S,
Tsai LT
, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J,
Brook OR
,
Chen J
, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R,
Gazal S
, Gould J, Grzyb J, Harvey T,
Hecht J
, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M,
Padera R
, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E,
Waghray A
, Warren S,
Zhang S
, Zollinger DR,
Cosimi L
,
Gupta RM
,
Hacohen N
, Hibshoosh H,
Hide W
,
Price AL
,
Rajagopal J
, Tata PR,
Riedel S
,
Szabo G
, Tickle TL,
Ellinor PT
,
Hung D
,
Sabeti PC
, Novak R, Rogers R,
Ingber DE
,
Jiang ZG
,
Juric D
, Babadi M, Farhi SL, Izar B,
Stone JR
,
Vlachos IS
,
Solomon IH
, Ashenberg O, Porter CBM, Li B,
Shalek AK
, et al. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113.
PMID:
33915569
; PMCID:
PMC8919505
.
Citations:
104
Fields:
Sci
Science
Translation:
Humans
Cells
Regan J, Flynn JP, Rosenthal A, Jordan H, Li Y, Chishti R, Giguel F, Corry H, Coxen K, Fajnzylber J, Gillespie E,
Kuritzkes DR
,
Hacohen N
,
Goldberg MB
,
Filbin MR
, Yu XG,
Baden L
, Ribeiro RM, Perelson AS, Conway JM,
Li JZ
. Viral Load Kinetics of Severe Acute Respiratory Syndrome Coronavirus 2 in Hospitalized Individuals With Coronavirus Disease 2019. Open Forum Infect Dis. 2021 Aug; 8(8):ofab153.
PMID:
34430669
; PMCID:
PMC8083268
.
Citations:
8
Nasser J
, Bergman DT, Fulco CP, Guckelberger P, Doughty BR, Patwardhan TA, Jones TR, Nguyen TH, Ulirsch JC, Lekschas F, Mualim K, Natri HM, Weeks EM, Munson G, Kane M, Kang HY, Cui A, Ray JP, Eisenhaure TM,
Collins RL
,
Dey K
, Pfister H,
Price AL
, Epstein CB, Kundaje A,
Xavier RJ
,
Daly MJ
, Huang H,
Finucane HK
,
Hacohen N
,
Lander ES
, Engreitz JM. Genome-wide enhancer maps link risk variants to disease genes. Nature. 2021 05; 593(7858):238-243.
PMID:
33828297
; PMCID:
PMC9153265
.
Citations:
42
Fields:
Sci
Science
Translation:
Humans
Cells
Hajaj E, Zisman E, Tzaban S, Merims S, Cohen J, Klein S, Frankenburg S,
Sade-Feldman M
, Tabach Y, Yizhak K, Navon A, Stepensky P,
Hacohen N
, Peretz T, Veillette A, Karni R, Eisenberg G, Lotem M. Alternative Splicing of the Inhibitory Immune Checkpoint Receptor SLAMF6 Generates a Dominant Positive Form, Boosting T-cell Effector Functions. Cancer Immunol Res. 2021 06; 9(6):637-650.
PMID:
33762352
.
Citations:
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Gentili M,
Hacohen N
. Some antibodies can dampen antiviral defences in people with severe COVID. Nature. 2021 03; 591(7848):37-39.
PMID:
33654298
.
Citations:
1
Fields:
Sci
Science
Translation:
Humans
Cells
de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP,
Hacohen N
, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O'Toole JF, Palevsky PM, Parikh CR, Poggio ED,
Rosas SE
, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA,
Waikar SS
, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J. Rationale and design of the Kidney Precision Medicine Project. Kidney Int. 2021 03; 99(3):498-510.
PMID:
33637194
; PMCID:
PMC8330551
.
Citations:
22
Fields:
Nep
Nephrology
Translation:
Humans
Li Y, Schneider AM,
Mehta A
,
Sade-Feldman M
, Kays KR, Gentili M, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Parry BA,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF, Regan J, Flynn JP,
Villani AC
,
Hacohen N
,
Goldberg MB
,
Filbin MR
,
Li JZ
. SARS-CoV-2 Viremia is Associated with Distinct Proteomic Pathways and Predicts COVID-19 Outcomes. medRxiv. 2021 Feb 26.
PMID:
33655257
; PMCID:
PMC7924277
.
Citations:
Delorey TM, Ziegler CGK, Heimberg G,
Normand R
, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ,
Subramanian A
, Montoro DT,
Jagadeesh KA
,
Dey KK
, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N,
Ganna A
, Gomez J, Normandin E,
Naderi P
,
Popov YV
, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J,
Brook OR
, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R,
Gazal S
, Gould J, Grzyb J, Harvey T,
Hecht J
, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M,
Padera R
, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E,
Waghray A
, Warren S, Zhang S, Zollinger DR,
Cosimi L
,
Gupta RM
,
Hacohen N
,
Hide W
,
Price AL
,
Rajagopal J
, Tata PR,
Riedel S
,
Szabo G
, Tickle TL,
Hung D
,
Sabeti PC
, Novak R, Rogers R,
Ingber DE
, Gordon Jiang Z,
Juric D
, Babadi M, Farhi SL,
Stone JR
, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B,
Shalek AK
, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25.
PMID:
33655247
.
Citations:
4
Choi JE, Sebastian C,
Ferrer CM
, Lewis CA,
Sade-Feldman M
, LaSalle T, Gonye A, Lopez BGC, Abdelmoula WM, Regan MS,
Cetinbas M
, Pascual G, Wojtkiewicz GR, Silveira GG, Boon R,
Ross KN
, Tirosh I,
Saladi SV
,
Ellisen LW
,
Sadreyev RI
, Benitah SA, Agar NYR,
Hacohen N
,
Mostoslavsky R
. A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma. Nat Metab. 2021 02; 3(2):182-195.
PMID:
33619381
; PMCID:
PMC7954080
.
Citations:
3
Fields:
Met
Metabolism
Translation:
Humans
Animals
Cells
Lo JA
, Kawakubo M, Juneja VR,
Su MY
,
Erlich TH
,
LaFleur MW
,
Kemeny LV
, Rashid M, Malehmir M, Rabi SA, Raghavan R, Allouche J, Kasumova G, Frederick DT, Pauken KE, Weng QY, Pereira da Silva M, Xu Y, van der Sande AAJ, Silkworth W,
Roider E
, Browne EP, Lieb DJ, Wang B, Garraway LA,
Wu CJ
,
Flaherty KT
, Brinckerhoff CE, Mullins DW, Adams DJ,
Hacohen N
,
Hoang MP
,
Boland GM
,
Freeman GJ
,
Sharpe AH
,
Manstein D
,
Fisher DE
. Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses. Sci Transl Med. 2021 02 17; 13(581).
PMID:
33597266
.
Citations:
20
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Hu Z, Leet DE, Allesøe RL,
Oliveira G
, Li S, Luoma AM, Liu J, Forman J, Huang T,
Iorgulescu JB
, Holden R, Sarkizova S, Gohil SH, Redd RA, Sun J, Elagina L, Giobbie-Hurder A, Zhang W, Peter L, Ciantra Z,
Rodig S
, Olive O, Shetty K, Pyrdol J, Uduman M, Lee PC, Bachireddy P,
Buchbinder EI
,
Yoon CH
,
Neuberg D
, Pentelute BL,
Hacohen N
, Livak KJ, Shukla SA, Olsen LR,
Barouch DH
,
Wucherpfennig KW
,
Fritsch EF
,
Keskin DB
,
Wu CJ
,
Ott PA
. Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 03; 27(3):515-525.
PMID:
33479501
; PMCID:
PMC8273876
.
Citations:
53
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Desai N, Neyaz A, Szabolcs A,
Shih AR
,
Chen JH
, Thapar V, Nieman LT, Solovyov A,
Mehta A
, Lieb DJ, Kulkarni AS, Jaicks C, Xu KH, Raabe MJ, Pinto CJ,
Juric D
,
Chebib I
,
Colvin RB
,
Kim AY
, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD,
Hacohen N
, Lagana SM,
Rivera MN
,
Sholl LM
,
Stone JR
, Ting DT,
Deshpande V
. Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection. Nat Commun. 2020 12 09; 11(1):6319.
PMID:
33298930
.
Citations:
67
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Fritsch EF
, Burkhardt UE,
Hacohen N
,
Wu CJ
. Personal Neoantigen Cancer Vaccines: A Road Not Fully Paved. Cancer Immunol Res. 2020 12; 8(12):1465-1469.
PMID:
33262163
.
Citations:
7
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
PH
Public Health
Hong X, Roh W, Sullivan RJ, Wong KHK,
Wittner BS
, Guo H, Dubash TD,
Sade-Feldman M
, Wesley B,
Horwitz E
,
Boland GM
, Marvin DL, Bonesteel T, Lu C, Aguet F,
Burr R
, Freeman SS, Parida L, Calhoun K, Jewett MK, Nieman LT,
Hacohen N
, Näär AM, Ting DT, Toner M,
Stott SL
,
Getz G
,
Maheswaran S
, Haber DA. The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis. Cancer Discov. 2021 03; 11(3):678-695.
PMID:
33203734
; PMCID:
PMC7933049
.
Citations:
26
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Filbin MR
,
Mehta A
, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN,
Rojas-Lopez M
, Russo BC, Sharma N, Tantivit J, Thomas MF,
Gerszten RE
, Heimberg GS,
Hoover PJ
, Lieb DJ, Lin B, Ngo D, Pelka K, Reyes M,
Smillie CS
,
Waghray A
,
Wood TE
, Zajac AS, Jennings LL, Grundberg I,
Bhattacharyya RP
, Parry BA,
Villani AC
,
Sade-Feldman M
,
Hacohen N
,
Goldberg MB
. Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients. bioRxiv. 2020 Nov 03.
PMID:
33173871
; PMCID:
PMC7654866
.
Citations:
1
Chen X, Gentili M,
Hacohen N
, Regev A. A cell-free antibody engineering platform rapidly generates SARS-CoV-2 neutralizing antibodies. bioRxiv. 2020 Oct 30.
PMID:
33140055
; PMCID:
PMC7605568
.
Citations:
Chia BS, Li B, Cui A, Eisenhaure T, Raychowdhury R, Lieb D,
Hacohen N
. Loss of the Nuclear Protein RTF2 Enhances Influenza Virus Replication. J Virol. 2020 10 27; 94(22).
PMID:
32878895
.
Citations:
2
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
Weingarten-Gabbay S, Klaeger S, Sarkizova S, Pearlman LR, Chen DY, Bauer MR, Taylor HB, Conway HL, Tomkins-Tinch CH, Finkel Y, Nachshon A, Gentili M, Rivera KD,
Keskin DB
, Rice CM, Clauser KR,
Hacohen N
, Carr SA, Abelin JG, Saeed M,
Sabeti PC
. SARS-CoV-2 infected cells present HLA-I peptides from canonical and out-of-frame ORFs. bioRxiv. 2020 Oct 26.
PMID:
33024965
; PMCID:
PMC7536868
.
Citations:
5
Wells DK, van Buuren MM, Dang KK, Hubbard-Lucey VM, Sheehan KCF, Campbell KM, Lamb A, Ward JP, Sidney J, Blazquez AB, Rech AJ, Zaretsky JM, Comin-Anduix B, Ng AHC, Chour W, Yu TV, Rizvi H, Chen JM, Manning P, Steiner GM, Doan XC, Merghoub T, Guinney J, Kolom A, Selinsky C, Ribas A, Hellmann MD,
Hacohen N
, Sette A, Heath JR, Bhardwaj N, Ramsdell F, Schreiber RD, Schumacher TN, Kvistborg P, Defranoux NA. Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction. Cell. 2020 10 29; 183(3):818-834.e13.
PMID:
33038342
.
Citations:
78
Fields:
Cel
Cell Biology
Translation:
Humans
Shrock E, Fujimura E,
Kula T
, Timms RT, Lee IH, Leng Y, Robinson ML, Sie BM, Li MZ, Chen Y, Logue J, Zuiani A, McCulloch D, Lelis FJN, Henson S, Monaco DR, Travers M, Habibi S, Clarke WA, Caturegli P, Laeyendecker O, Piechocka-Trocha A,
Li JZ
,
Khatri A
, Chu HY,
Villani AC
, Kays K,
Goldberg MB
,
Hacohen N
,
Filbin MR
, Yu XG,
Walker BD
,
Wesemann DR
, Larman HB,
Lederer JA
,
Elledge SJ
. Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity. Science. 2020 11 27; 370(6520).
PMID:
32994364
; PMCID:
PMC7857405
.
Citations:
204
Fields:
Sci
Science
Translation:
Humans
Cells
Myers SA, Rhoads A, Cocco AR, Peckner R,
Haber AL
, Schweitzer LD, Krug K, Mani DR, Clauser KR, Rozenblatt-Rosen O,
Hacohen N
, Regev A, Carr SA. Streamlined Protocol for Deep Proteomic Profiling of FAC-sorted Cells and Its Application to Freshly Isolated Murine Immune Cells. Mol Cell Proteomics. 2019 May; 18(5):995-1009.
PMID:
33451796
.
Citations:
Miller PG
,
Gibson CJ
,
Mehta A
,
Sperling AS
, Frederick DT, Manos MP, Miao B,
Hacohen N
,
Hodi FS
,
Boland GM
,
Ebert BL
. Fitness Landscape of Clonal Hematopoiesis Under Selective Pressure of Immune Checkpoint Blockade. JCO Precis Oncol. 2020; 4.
PMID:
33015529
; PMCID:
PMC7529531
.
Citations:
4
Fields:
Neo
Neoplasms
Reyes M,
Filbin MR
,
Bhattacharyya RP
,
Sonny A
,
Mehta A
, Billman K, Kays KR, Pinilla-Vera M, Benson ME,
Cosimi LA
,
Hung DT
, Levy BD,
Villani AC
,
Sade-Feldman M
,
Baron RM
,
Goldberg MB
, Blainey PC,
Hacohen N
. Induction of a regulatory myeloid program in bacterial sepsis and severe COVID-19. bioRxiv. 2020 Sep 02.
PMID:
32908980
; PMCID:
PMC7480031
.
Citations:
Johnstone SE
, Reyes A, Qi Y,
Adriaens C
, Hegazi E, Pelka K,
Chen JH
, Zou LS, Drier Y, Hecht V, Shoresh N, Selig MK, Lareau CA, Iyer S, Nguyen SC, Joyce EF,
Hacohen N
,
Irizarry RA
, Zhang B,
Aryee MJ
,
Bernstein BE
. Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer. Cell. 2020 09 17; 182(6):1474-1489.e23.
PMID:
32841603
.
Citations:
25
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Lareau CA, Ludwig LS, Muus C, Gohil SH, Zhao T, Chiang Z, Pelka K, Verboon JM, Luo W, Christian E, Rosebrock D,
Getz G
,
Boland GM
, Chen F,
Buenrostro JD
,
Hacohen N
,
Wu CJ
,
Aryee MJ
, Regev A,
Sankaran VG
. Massively parallel single-cell mitochondrial DNA genotyping and chromatin profiling. Nat Biotechnol. 2021 04; 39(4):451-461.
PMID:
32788668
.
Citations:
38
Fields:
Bio
Biotechnology
Translation:
Humans
Cells
Desai N, Neyaz A, Szabolcs A,
Shih AR
,
Chen JH
, Thapar V, Nieman LT, Solovyov A,
Mehta A
, Lieb DJ, Kulkarni AS, Jaicks C, Pinto CJ,
Juric D
,
Chebib I
,
Colvin RB
,
Kim AY
, Monroe R, Warren SE, Danaher P, Reeves JW, Gong J, Rueckert EH, Greenbaum BD,
Hacohen N
, Lagana SM,
Rivera MN
,
Sholl LM
,
Stone JR
, Ting DT,
Deshpande V
. Temporal and Spatial Heterogeneity of Host Response to SARS-CoV-2 Pulmonary Infection. medRxiv. 2020 Aug 02.
PMID:
32766600
.
Citations:
1
Li B, Gould J, Yang Y, Sarkizova S, Tabaka M, Ashenberg O, Rosen Y, Slyper M, Kowalczyk MS,
Villani AC
, Tickle T,
Hacohen N
, Rozenblatt-Rosen O, Regev A. Cumulus provides cloud-based data analysis for large-scale single-cell and single-nucleus RNA-seq. Nat Methods. 2020 08; 17(8):793-798.
PMID:
32719530
.
Citations:
27
Fields:
Cli
Clinical Laboratory Techniques
Marigo I, Trovato R, Hofer F, Ingangi V, Desantis G, Leone K, De Sanctis F, Ugel S, Canè S, Simonelli A, Lamolinara A, Iezzi M, Fassan M, Rugge M, Boschi F, Borile G, Eisenhaure T, Sarkizova S, Lieb D,
Hacohen N
, Azzolin L, Piccolo S, Lawlor R, Scarpa A, Carbognin L, Bria E, Bicciato S, Murray PJ, Bronte V. Disabled Homolog 2 Controls Prometastatic Activity of Tumor-Associated Macrophages. Cancer Discov. 2020 11; 10(11):1758-1773.
PMID:
32651166
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Fava A, Buyon J, Mohan C, Zhang T, Belmont HM, Izmirly P, Clancy R, Trujillo JM, Fine D, Zhang Y, Magder L, Rao DA, Arazi A, Berthier CC, Davidson A, Diamond B,
Hacohen N
, Wofsy D, Apruzzese W,
Raychaudhuri S
, Petri M. Integrated urine proteomics and renal single-cell genomics identify an IFN-? response gradient in lupus nephritis. JCI Insight. 2020 06 18; 5(12).
PMID:
32396533
.
Citations:
14
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
de Boer CG, Ray JP,
Hacohen N
, Regev A. MAUDE: inferring expression changes in sorting-based CRISPR screens. Genome Biol. 2020 06 03; 21(1):134.
PMID:
32493396
.
Citations:
3
Fields:
Gen
Genetics
Translation:
Cells
Ding J, Adiconis X, Simmons SK, Kowalczyk MS, Hession CC, Marjanovic ND, Hughes TK, Wadsworth MH, Burks T, Nguyen LT,
Kwon JYH
, Barak B, Ge W, Kedaigle AJ, Carroll S, Li S,
Hacohen N
, Rozenblatt-Rosen O,
Shalek AK
,
Villani AC
, Regev A, Levin JZ. Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods. Nat Biotechnol. 2020 06; 38(6):756.
PMID:
32341567
.
Citations: