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profileScott Brian Snapper, M.D.,Ph.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressChildren's Hospital
Gastroenterology
300 Longwood Ave
Boston MA 02115
Fax617/730-0498
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Collapse Mentoring 
Collapse completed student projects
Characterizing Colitis in WASP-deficient Mice as a Murine Model of Inflammatory Bowel Disease
Full Time/Year Long, 09/01/99 - 08/01/00
Characterizing Colitis in WASP-deficient Mice as a Murine Model of Inflammatory Bowel Disease
Part Time/Continuation, 09/01/00 - 01/31/01

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56AI125766     (SNAPPER, SCOTT B)Aug 8, 2017 - Jul 31, 2018
NIH/NIAID
Employing novel humanized murine strains to develop hematopoietic stem cell gene therapeutic approaches for very early-onset inflammatory bowel disease due to IL10-receptor deficiency.
Role: Principal Investigator

R01DK115217     (SNAPPER, SCOTT B)Aug 1, 2017 - Jul 31, 2021
NIH/NIDDK
Type III interferon Control of Mucosal Immunity
Role: Principal Investigator

R01AI052354     (SNAPPER, SCOTT B)Sep 15, 2003 - Dec 31, 2009
NIH/NIAID
Cytoskeletal-Pathogen Interactions in Shigella Infection
Role: Principal Investigator

R01AI050950     (SNAPPER, SCOTT B)Apr 5, 2002 - Jan 31, 2015
NIH/NIAID
Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis
Role: Principal Investigator

R56AI050950     (SNAPPER, SCOTT B)Apr 5, 2002 - Feb 14, 2009
NIH/NIAID
Exploring Regulatory T Cell Dysfunction in a Murine Model of Colitis
Role: Principal Investigator
Collapse research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Epithelial Cell Biology Core (BCH) - Core services (6) and Instruments (21)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li K, Strauss R, Ouahed J, Chan D, Telesco SE, Shouval DS, Canavan JB, Brodmerkel C, Snapper SB, Friedman JR. Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. J Pediatr Gastroenterol Nutr. 2018 Feb 03. PMID: 29401083.
    View in: PubMed
  2. Haberman Y, BenShoshan M, Di Segni A, Dexheimer PJ, Braun T, Weiss B, Walters TD, Baldassano RN, Noe JD, Markowitz J, Rosh J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Kellermayer R, Patel A, Otley A, Steiner SJ, Gulati AS, Guthery SL, LeLeiko N, Moulton D, Kirschner BS, Snapper S, Avivi C, Barshack I, Oliva-Hemker M, Cohen SA, Keljo DJ, Ziring D, Anikster Y, Aronow B, Hyams JS, Kugathasan S, Denson LA. Long ncRNA Landscape in the Ileum of Treatment-Naive Early-Onset Crohn Disease. Inflamm Bowel Dis. 2018 Jan 18; 24(2):346-360. PMID: 29361088.
    View in: PubMed
  3. Sallis BF, Erkert L, Moñino-Romero S, Acar U, Wu R, Konnikova L, Lexmond WS, Hamilton MJ, Dunn WA, Szepfalusi Z, Vanderhoof JA, Snapper SB, Turner JR, Goldsmith JD, Spencer LA, Nurko S, Fiebiger E. An algorithm for the classification of mRNA patterns in eosinophilic esophagitis: Integration of machine learning. J Allergy Clin Immunol. 2017 Dec 19. PMID: 29273402.
    View in: PubMed
  4. Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB. Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm Bowel Dis. 2017 Nov; 23(11):1950-1961. PMID: 29023267.
    View in: PubMed
  5. Kuznetsov NV, Almuzzaini B, Kritikou JS, Baptista MAP, Oliveira MMS, Keszei M, Snapper SB, Percipalle P, Westerberg LS. Nuclear Wiskott-Aldrich syndrome protein co-regulates T cell factor 1-mediated transcription in T cells. Genome Med. 2017 Oct 27; 9(1):91. PMID: 29078804.
    View in: PubMed
  6. Han L, Maciejewski M, Brockel C, Gordon W, Snapper SB, Korzenik JR, Afzelius L, Altman RB. A PRObabilistic Pathway Score (PROPS) for Classification with Applications to Inflammatory Bowel Disease. Bioinformatics. 2017 Oct 18. PMID: 29048458.
    View in: PubMed
  7. Lexmond WS, Goettel JA, Sallis BF, McCann K, Rings EHHM, Jensen-Jarolim E, Nurko S, Snapper SB, Fiebiger E. Spontaneous food allergy in Was-/- mice occurs independent of FceRI-mediated mast cell activation. Allergy. 2017 Dec; 72(12):1916-1924. PMID: 28600891.
    View in: PubMed
  8. Redhu NS, Bakthavatchalu V, Conaway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang C, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017 Jul 05; 6. PMID: 28678006.
    View in: PubMed
  9. Ozen A, Comrie WA, Ardy RC, Domínguez Conde C, Dalgic B, Beser ÖF, Morawski AR, Karakoc-Aydiner E, Tutar E, Baris S, Ozcay F, Serwas NK, Zhang Y, Matthews HF, Pittaluga S, Folio LR, Unlusoy Aksu A, McElwee JJ, Krolo A, Kiykim A, Baris Z, Gulsan M, Ogulur I, Snapper SB, Houwen RHJ, Leavis HL, Ertem D, Kain R, Sari S, Erkan T, Su HC, Boztug K, Lenardo MJ. CD55 Deficiency, Early-Onset Protein-Losing Enteropathy, and Thrombosis. N Engl J Med. 2017 07 06; 377(1):52-61. PMID: 28657829.
    View in: PubMed
  10. Zitomersky NL, Demers M, Martinod K, Gallant M, Cifuni SM, Biswas A, Snapper S, Wagner DD. ADAMTS13 Deficiency Worsens Colitis and Exogenous ADAMTS13 Administration Decreases Colitis Severity in Mice. TH Open. 2017 Jun; 1(1):e11-e23. PMID: 29376146.
    View in: PubMed
  11. Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 05 25; 545(7655):432-438. PMID: 28514439.
    View in: PubMed
  12. Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017 05 05; 356(6337):513-519. PMID: 28473584.
    View in: PubMed
  13. Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet. 2017 Apr 29; 389(10080):1710-1718. PMID: 28259484.
    View in: PubMed
  14. Conaway EA, de Oliveira DC, McInnis CM, Snapper SB, Horwitz BH. Inhibition of Inflammatory Gene Transcription by IL-10 Is Associated with Rapid Suppression of Lipopolysaccharide-Induced Enhancer Activation. J Immunol. 2017 04 01; 198(7):2906-2915. PMID: 28213503.
    View in: PubMed
  15. Mrakotsky C, Augustine DW, Watson C, Canavan J, Rivkin M, Snapper S. O-003 The Brain as Extraintestinal IBD Manifestation: Are Brain and Cognitive Differences in Pediatric Crohn's Disease Associated with Immune Gene Expression? Inflamm Bowel Dis. 2017 Feb; 23 Suppl 1:S1-S2. PMID: 28125551.
    View in: PubMed
  16. Goettel J, Kotlarz D, Illig D, Canavan J, Allegretti J, Hamilton M, Kelly R, Griffith A, Carellas M, Nelina A, Bousvaros A, Korzenik J, Snapper S. O-011 Low-dose IL-2 Administration Expands Human Regulatory T Cells in Patients with UC and Humanized Mice and Protects Against Experimental Colitis. Inflamm Bowel Dis. 2017 Feb; 23 Suppl 1:S4. PMID: 28125559.
    View in: PubMed
  17. Li J, Shouval DS, Doty AL, Snapper SB, Glover SC. Erratum to: Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing. J Clin Immunol. 2017 Feb; 37(2):108. PMID: 28127684.
    View in: PubMed
  18. Li J, Shouval D, Doty A, Snapper S, Glover S. P356 Treatment with anakinra induces T cell production of IL22 and GI mucosal healing in an IL-10RA mutation patient. J Crohns Colitis. 2017 Feb 01; 11(suppl_1):S258. PMID: 28172748.
    View in: PubMed
  19. Shouval D, Konnikova L, Werner L, Nunberg M, Weiss B, Glover S, Snapper S. DOP082 Enhanced TH17 responses in patients with IL10 receptor deficiency and history of infantile-onset IBD. J Crohns Colitis. 2017 Feb 01; 11(suppl_1):S75. PMID: 28172704.
    View in: PubMed
  20. Schoellhammer CM, Lauwers GY, Goettel JA, Oberli MA, Cleveland C, Park JY, Minahan D, Chen Y, Anderson DG, Jaklenec A, Snapper SB, Langer R, Traverso G. Ultrasound-Mediated Delivery of RNA to Colonic Mucosa of Live Mice. Gastroenterology. 2017 Apr; 152(5):1151-1160. PMID: 28088460.
    View in: PubMed
  21. Li J, Shouval DS, Doty AL, Snapper SB, Glover SC. Increased Mucosal IL-22 Production of an IL-10RA Mutation Patient Following Anakinra Treatment Suggests Further Mechanism for Mucosal Healing. J Clin Immunol. 2017 Feb; 37(2):104-107. PMID: 28064389.
    View in: PubMed
  22. Poholek AC, Jankovic D, Villarino AV, Petermann F, Hettinga A, Shouval DS, Snapper SB, Kaech SM, Brooks SR, Vahedi G, Sher A, Kanno Y, O'Shea JJ. IL-10 induces a STAT3-dependent autoregulatory loop in TH2 cells that promotes Blimp-1 restriction of cell expansion via antagonism of STAT5 target genes. Sci Immunol. 2016 Oct; 1(5). PMID: 28713870.
    View in: PubMed
  23. Goettel JA, Gandhi R, Kenison JE, Yeste A, Murugaiyan G, Sambanthamoorthy S, Griffith AE, Patel B, Shouval DS, Weiner HL, Snapper SB, Quintana FJ. AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice. Cell Rep. 2016 10 25; 17(5):1318-1329. PMID: 27783946.
    View in: PubMed
  24. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735.
    View in: PubMed
  25. Shouval DS, Biswas A, Kang YH, Griffith AE, Konnikova L, Mascanfroni ID, Redhu NS, Frei SM, Field M, Doty AL, Goldsmith JD, Bhan AK, Loizides A, Weiss B, Yerushalmi B, Yanagi T, Lui X, Quintana FJ, Muise AM, Klein C, Horwitz BH, Glover SC, Bousvaros A, Snapper SB. Interleukin 1ß Mediates Intestinal Inflammation in Mice and Patients With Interleukin 10 Receptor Deficiency. Gastroenterology. 2016 Dec; 151(6):1100-1104. PMID: 27693323.
    View in: PubMed
  26. Lexmond WS, Goettel JA, Lyons JJ, Jacobse J, Deken MM, Lawrence MG, DiMaggio TH, Kotlarz D, Garabedian E, Sackstein P, Nelson CC, Jones N, Stone KD, Candotti F, Rings EH, Thrasher AJ, Milner JD, Snapper SB, Fiebiger E. FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. J Clin Invest. 2016 Oct 03; 126(10):4030-4044. PMID: 27643438.
    View in: PubMed
  27. Baptista MA, Keszei M, Oliveira M, Sunahara KK, Andersson J, Dahlberg CI, Worth AJ, Liedén A, Kuo IC, Wallin RP, Snapper SB, Eidsmo L, Scheynius A, Karlsson MC, Bouma G, Burns SO, Forsell MN, Thrasher AJ, Nylén S, Westerberg LS. Deletion of Wiskott-Aldrich syndrome protein triggers Rac2 activity and increased cross-presentation by dendritic cells. Nat Commun. 2016 Jul 18; 7:12175. PMID: 27425374; PMCID: PMC4960314.
  28. Wang ZB, Ma XS, Hu MW, Jiang ZZ, Meng TG, Dong MZ, Fan LH, Ouyang YC, Snapper SB, Schatten H, Sun QY. Oocyte-specific deletion of N-WASP does not affect oocyte polarity, but causes failure of meiosis II completion. Mol Hum Reprod. 2016 Sep; 22(9):613-21. PMID: 27401749.
    View in: PubMed
  29. Shouval DS, Ebens CL, Murchie R, McCann K, Rabah R, Klein C, Muise AM, Snapper SB. Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 2016 07; 63(1):e15-7. PMID: 27336593; PMCID: PMC4605893.
  30. Wagener BM, Hu M, Zheng A, Zhao X, Che P, Brandon A, Anjum N, Snapper S, Creighton J, Guan JL, Han Q, Cai GQ, Han X, Pittet JF, Ding Q. Neuronal Wiskott-Aldrich syndrome protein regulates TGF-ß1-mediated lung vascular permeability. FASEB J. 2016 07; 30(7):2557-69. PMID: 27025963; PMCID: PMC4904290 [Available on 07/01/17].
  31. Redhu N, Shouval D, Bakthavatchalu V, Wang C, Conaway E, Goettel J, Mack M, Bleich A, Bry L, Fox J, Snapper S, Horwitz B. O-005 YI Microbiota Drives Inflammation by Altering Intestinal Lamina Propria Macrophage Phenotype in a Novel IL10R-Deficient Model of Very Early Onset IBD. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S2-3. PMID: 26849723.
    View in: PubMed
  32. Koroleva E, Muraoka W, Spencer C, Gubernatorova E, Halperin S, Snapper S, Tumanov A. O-009 Lymphotoxin Links Microbiota and Group 3 Innate Lymphoid Cells to Protect Against Intestinal Inflammation. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S3-4. PMID: 26849727.
    View in: PubMed
  33. Mrakotsky C, Anand R, Watson C, Vu C, Matos A, Friel S, Rivkin M, Snapper S. O-018 New Evidence for Structural Brain Differences in Pediatric Crohn's Disease: Impact of Underlying Disease Factors. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S6-7. PMID: 26849735.
    View in: PubMed
  34. Biswas A, Shouval D, Goettel J, Field M, Griffith A, Pai SY, Notarangelo L, Geha R, Snapper S. O-008 Aberrant Anti-inflammatory Macrophage Function and Differentiation in Wiskott-Aldrich Syndrome Protein-Deficient Mice and Humans. Inflamm Bowel Dis. 2016 Mar; 22 Suppl 1:S3. PMID: 26849726.
    View in: PubMed
  35. Li Q, Lee CH, Peters LA, Mastropaolo LA, Thoeni C, Elkadri A, Schwerd T, Zhu J, Zhang B, Zhao Y, Hao K, Dinarzo A, Hoffman G, Kidd BA, Murchie R, Al Adham Z, Guo C, Kotlarz D, Cutz E, Walters TD, Shouval DS, Curran M, Dobrin R, Brodmerkel C, Snapper SB, Klein C, Brumell JH, Hu M, Nanan R, Snanter-Nanan B, Wong M, Le Deist F, Haddad E, Roifman CM, Deslandres C, Griffiths AM, Gaskin KJ, Uhlig HH, Schadt EE, Muise AM. Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease. Gastroenterology. 2016 05; 150(5):1196-1207. PMID: 26836588; PMCID: PMC4842103 [Available on 05/01/17].
  36. Yanagi T, Mizuochi T, Takaki Y, Eda K, Mitsuyama K, Ishimura M, Takada H, Shouval DS, Griffith AE, Snapper SB, Yamashita Y, Yamamoto K. Novel exonic mutation inducing aberrant splicing in the IL10RA gene and resulting in infantile-onset inflammatory bowel disease: a case report. BMC Gastroenterol. 2016 Jan 28; 16:10. PMID: 26822028; PMCID: PMC4730728.
  37. Volpi S, Santori E, Abernethy K, Mizui M, Dahlberg CI, Recher M, Capuder K, Csizmadia E, Ryan D, Mathew D, Tsokos GC, Snapper S, Westerberg LS, Thrasher AJ, Candotti F, Notarangelo LD. N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome. Blood. 2016 Jan 14; 127(2):216-20. PMID: 26468226; PMCID: PMC4713162.
  38. Hayes P, Dhillon S, O'Neill K, Thoeni C, Hui KY, Elkadri A, Guo CH, Kovacic L, Aviello G, Alvarez LA, Griffiths AM, Snapper SB, Brant SR, Doroshow JH, Silverberg MS, Peter I, McGovern DP, Cho J, Brumell JH, Uhlig HH, Bourke B, Muise AA, Knaus UG. Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease. Cell Mol Gastroenterol Hepatol. 2015 Sep 01; 1(5):489-502. PMID: 26301257.
    View in: PubMed
  39. Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. MUCOSAL IMMUNOLOGY. Individual intestinal symbionts induce a distinct population of ROR?? regulatory T cells. Science. 2015 Aug 28; 349(6251):993-7. PMID: 26272906; PMCID: PMC4700932.
  40. Snapper SB. Very-Early-Onset Inflammatory Bowel Disease. Gastroenterol Hepatol (N Y). 2015 Aug; 11(8):554-6. PMID: 27118953; PMCID: PMC4843045.
  41. Dahlberg CI, Torres ML, Petersen SH, Baptista MA, Keszei M, Volpi S, Grasset EK, Karlsson MC, Walter JE, Snapper SB, Notarangelo LD, Westerberg LS. Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies. J Autoimmun. 2015 Aug; 62:81-92. PMID: 26143192.
    View in: PubMed
  42. Moran CJ, Klein C, Muise AM, Snapper SB. Very early-onset inflammatory bowel disease: gaining insight through focused discovery. Inflamm Bowel Dis. 2015 May; 21(5):1166-75. PMID: 25895007.
    View in: PubMed
  43. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. PMID: 25833964; PMCID: PMC4473116.
  44. Uhlig HH, Schwerd T, Koletzko S, Shah N, Kammermeier J, Elkadri A, Ouahed J, Wilson DC, Travis SP, Turner D, Klein C, Snapper SB, Muise AM. The diagnostic approach to monogenic very early onset inflammatory bowel disease. Gastroenterology. 2014 Nov; 147(5):990-1007.e3. PMID: 25058236.
    View in: PubMed
  45. Wurbel MA, Le Bras S, Ibourk M, Pardo M, McIntire MG, Coco D, Geha RS, Fiebiger E, Snapper SB. CCL25/CCR9 interactions are not essential for colitis development but are required for innate immune cell protection from chronic experimental murine colitis. Inflamm Bowel Dis. 2014 Jul; 20(7):1165-76. PMID: 24874458.
    View in: PubMed
  46. Xiao X, Mruk DD, Tang EI, Massarwa R, Mok KW, Li N, Wong CK, Lee WM, Snapper SB, Shilo BZ, Schejter ED, Cheng CY. N-wasp is required for structural integrity of the blood-testis barrier. PLoS Genet. 2014 Jun; 10(6):e1004447. PMID: 24967734; PMCID: PMC4072540.
  47. Benchimol EI, Mack DR, Nguyen GC, Snapper SB, Li W, Mojaverian N, Quach P, Muise AM. Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease. Gastroenterology. 2014 Oct; 147(4):803-813.e7; quiz e14-5. PMID: 24951840.
    View in: PubMed
  48. Dhillon SS, Fattouh R, Elkadri A, Xu W, Murchie R, Walters T, Guo C, Mack D, Huynh HQ, Baksh S, Silverberg MS, Griffiths AM, Snapper SB, Brumell JH, Muise AM. Variants in nicotinamide adenine dinucleotide phosphate oxidase complex components determine susceptibility to very early onset inflammatory bowel disease. Gastroenterology. 2014 Sep; 147(3):680-689.e2. PMID: 24931457.
    View in: PubMed
  49. Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM. The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cell Microbiol. 2014 Sep; 16(9):1405-24. PMID: 24780054; PMCID: PMC4146666.
  50. Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB. Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity. 2014 May 15; 40(5):706-19. PMID: 24792912; PMCID: PMC4513358.
  51. Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Müller W, Snapper SB, Schreiber S, Kaser A, Zeissig S, Blumberg RS. Protective mucosal immunity mediated by epithelial CD1d and IL-10. Nature. 2014 May 22; 509(7501):497-502. PMID: 24717441; PMCID: PMC4132962.
  52. Murugan D, Albert MH, Langemeier J, Bohne J, Puchalka J, Järvinen PM, Hauck F, Klenk AK, Prell C, Schatz S, Diestelhorst J, Sciskala B, Kohistani N, Belohradsky BH, Müller S, Kirchner T, Walter MR, Bufler P, Muise AM, Snapper SB, Koletzko S, Klein C, Kotlarz D. Very early onset inflammatory bowel disease associated with aberrant trafficking of IL-10R1 and cure by T cell replete haploidentical bone marrow transplantation. J Clin Immunol. 2014 Apr; 34(3):331-9. PMID: 24519095.
    View in: PubMed
  53. Dhillon SS, Mastropaolo LA, Murchie R, Griffiths C, Thöni C, Elkadri A, Xu W, Mack A, Walters T, Guo C, Mack D, Huynh H, Baksh S, Silverberg MS, Brumell JH, Snapper SB, Muise AM. Higher activity of the inducible nitric oxide synthase contributes to very early onset inflammatory bowel disease. Clin Transl Gastroenterol. 2014 Jan 16; 5:e46. PMID: 24430113; PMCID: PMC3912315.
  54. Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM. Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease. Gastroenterology. 2014 Apr; 146(4):1028-39. PMID: 24417819; PMCID: PMC4002656.
  55. Shouval DS, Ouahed J, Biswas A, Goettel JA, Horwitz BH, Klein C, Muise AM, Snapper SB. Interleukin 10 receptor signaling: master regulator of intestinal mucosal homeostasis in mice and humans. Adv Immunol. 2014; 122:177-210. PMID: 24507158; PMCID: PMC4741283.
  56. Liu C, Bai X, Wu J, Sharma S, Upadhyaya A, Dahlberg CI, Westerberg LS, Snapper SB, Zhao X, Song W. N-wasp is essential for the negative regulation of B cell receptor signaling. PLoS Biol. 2013 Nov; 11(11):e1001704. PMID: 24223520; PMCID: PMC3818172.
  57. Nguyen DD, Muthupalani S, Goettel JA, Eston MA, Mobley M, Taylor NS, McCabe A, Marin R, Snapper SB, Fox JG. Colitis and colon cancer in WASP-deficient mice require helicobacter species. Inflamm Bowel Dis. 2013 Sep; 19(10):2041-50. PMID: 23820270; PMCID: PMC4082694.
  58. Lexmond WS, Pardo M, Rooney K, Goettel JA, Snapper SB, Yen EH, Dehlink E, Nurko S, Fiebiger E. Elevated levels of leukotriene C4 synthase mRNA distinguish a subpopulation of eosinophilic oesophagitis patients. Clin Exp Allergy. 2013 Aug; 43(8):902-13. PMID: 23889244; PMCID: PMC3728707.
  59. Zitomersky NL, Atkinson BJ, Franklin SW, Mitchell PD, Snapper SB, Comstock LE, Bousvaros A. Characterization of adherent bacteroidales from intestinal biopsies of children and young adults with inflammatory bowel disease. PLoS One. 2013; 8(6):e63686. PMID: 23776434; PMCID: PMC3679120.
  60. Schell C, Baumhakl L, Salou S, Conzelmann AC, Meyer C, Helmstädter M, Wrede C, Grahammer F, Eimer S, Kerjaschki D, Walz G, Snapper S, Huber TB. N-wasp is required for stabilization of podocyte foot processes. J Am Soc Nephrol. 2013 Apr; 24(5):713-21. PMID: 23471198; PMCID: PMC3636796.
  61. Moran CJ, Walters TD, Guo CH, Kugathasan S, Klein C, Turner D, Wolters VM, Bandsma RH, Mouzaki M, Zachos M, Langer JC, Cutz E, Benseler SM, Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM. IL-10R polymorphisms are associated with very-early-onset ulcerative colitis. Inflamm Bowel Dis. 2013 Jan; 19(1):115-23. PMID: 22550014; PMCID: PMC3744177.
  62. Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. PMID: 22966049; PMCID: PMC3497443.
  63. Kumar S, Xu J, Perkins C, Guo F, Snapper S, Finkelman FD, Zheng Y, Filippi MD. Cdc42 regulates neutrophil migration via crosstalk between WASp, CD11b, and microtubules. Blood. 2012 Oct 25; 120(17):3563-74. PMID: 22932798; PMCID: PMC3482864.
  64. Gruenbaum-Cohen Y, Harel I, Umansky KB, Tzahor E, Snapper SB, Shilo BZ, Schejter ED. The actin regulator N-WASp is required for muscle-cell fusion in mice. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11211-6. PMID: 22736793; PMCID: PMC3396508.
  65. Muise AM, Snapper SB, Kugathasan S. The age of gene discovery in very early onset inflammatory bowel disease. Gastroenterology. 2012 Aug; 143(2):285-8. PMID: 22727850.
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  66. Nguyen DD, Wurbel MA, Goettel JA, Eston MA, Ahmed OS, Marin R, Boden EK, Villablanca EJ, Paidassi H, Ahuja V, Reinecker HC, Fiebiger E, Lacy-Hulbert A, Horwitz BH, Mora JR, Snapper SB. Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology. 2012 Sep; 143(3):719-729.e2. PMID: 22710191; PMCID: PMC3760724.
  67. Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C. Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol. 2012 Apr 16; 13(9):R79. PMID: 23013615; PMCID: PMC3506950.
  68. Westerberg LS, Dahlberg C, Baptista M, Moran CJ, Detre C, Keszei M, Eston MA, Alt FW, Terhorst C, Notarangelo LD, Snapper SB. Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function. Blood. 2012 Apr 26; 119(17):3966-74. PMID: 22411869; PMCID: PMC3350364.
  69. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28. PMID: 22302739; PMCID: PMC3327460.
  70. Hamilton MJ, Snapper SB, Blumberg RS. Update on biologic pathways in inflammatory bowel disease and their therapeutic relevance. J Gastroenterol. 2012 Jan; 47(1):1-8. PMID: 22215058; PMCID: PMC4592148.
  71. Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Gut-tropic T cells that express integrin a4ß7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011 Dec; 141(6):2109-18. PMID: 21925467; PMCID: PMC3222333.
  72. Li A, Ma Y, Yu X, Mort RL, Lindsay CR, Stevenson D, Strathdee D, Insall RH, Chernoff J, Snapper SB, Jackson IJ, Larue L, Sansom OJ, Machesky LM. Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell. 2011 Oct 18; 21(4):722-34. PMID: 21924960; PMCID: PMC3464460.
  73. Rotkopf S, Hamberg Y, Aigaki T, Snapper SB, Shilo BZ, Schejter ED. The WASp-based actin polymerization machinery is required in somatic support cells for spermatid maturation and release. Development. 2011 Jul; 138(13):2729-39. PMID: 21652648.
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  74. Wang S, Villablanca EJ, De Calisto J, Gomes DC, Nguyen DD, Mizoguchi E, Kagan JC, Reinecker HC, Hacohen N, Nagler C, Xavier RJ, Rossi-Bergmann B, Chen YB, Blomhoff R, Snapper SB, Mora JR. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol. 2011 Jul 01; 187(1):141-50. PMID: 21646294; PMCID: PMC3119749.
  75. Ramasamy S, Nguyen DD, Eston MA, Alam SN, Moss AK, Ebrahimi F, Biswas B, Mostafa G, Chen KT, Kaliannan K, Yammine H, Narisawa S, Millán JL, Warren HS, Hohmann EL, Mizoguchi E, Reinecker HC, Bhan AK, Snapper SB, Malo MS, Hodin RA. Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis. Inflamm Bowel Dis. 2011 Feb; 17(2):532-42. PMID: 20645323; PMCID: PMC3154118.
  76. Novak N, Bar V, Sabanay H, Frechter S, Jaegle M, Snapper SB, Meijer D, Peles E. N-WASP is required for membrane wrapping and myelination by Schwann cells. J Cell Biol. 2011 Jan 24; 192(2):243-50. PMID: 21263026; PMCID: PMC3172181.
  77. Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM. Enterohemorrhagic E. coli requires N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation. PLoS Pathog. 2010 Aug 19; 6(8):e1001056. PMID: 20808845; PMCID: PMC2924363.
  78. Westerberg LS, Meelu P, Baptista M, Eston MA, Adamovich DA, Cotta-de-Almeida V, Seed B, Rosen MK, Vandenberghe P, Thrasher AJ, Klein C, Alt FW, Snapper SB. Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes. J Exp Med. 2010 Jun 07; 207(6):1145-52. PMID: 20513746; PMCID: PMC2882832.
  79. Lyubimova A, Garber JJ, Upadhyay G, Sharov A, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. J Clin Invest. 2010 Feb; 120(2):446-56. PMID: 20071778; PMCID: PMC2810069.
  80. Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009 Nov 19; 361(21):2033-45. PMID: 19890111; PMCID: PMC2787406.
  81. Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ. Phosphorylation of WASp is a key regulator of activity and stability in vivo. Proc Natl Acad Sci U S A. 2009 Sep 15; 106(37):15738-43. PMID: 19805221; PMCID: PMC2736139.
  82. Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology. 2009 Oct; 137(4):1380-90.e1-3. PMID: 19596011; PMCID: PMC2757440.
  83. Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB. Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys Res Commun. 2009 Jul 03; 384(3):284-9. PMID: 19379711; PMCID: PMC2697925.
  84. Nguyen DD, Snapper SB. Targeting Smads to restore transforming growth factor-beta signaling and regulatory T-cell function in inflammatory bowel disease. Gastroenterology. 2009 Apr; 136(4):1161-4. PMID: 19236965.
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  85. Westerberg LS, Klein C, Snapper SB. Breakdown of T cell tolerance and autoimmunity in primary immunodeficiency--lessons learned from monogenic disorders in mice and men. Curr Opin Immunol. 2008 Dec; 20(6):646-54. PMID: 18955138; PMCID: PMC2605935.
  86. Boden EK, Snapper SB. Regulatory T cells in inflammatory bowel disease. Curr Opin Gastroenterol. 2008 Nov; 24(6):733-41. PMID: 19125486.
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  87. Westerberg LS, de la Fuente MA, Wermeling F, Ochs HD, Karlsson MC, Snapper SB, Notarangelo LD. WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function. Blood. 2008 Nov 15; 112(10):4139-47. PMID: 18772454; PMCID: PMC2581999.
  88. Stenson WF, Snapper SB. Challenges in IBD research: Assessing progress and rethinking the research agenda. Inflamm Bowel Dis. 2008 May; 14(5):687-708. PMID: 18260124.
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  89. Zou Z, Horowitz LF, Montmayeur JP, Snapper S, Buck LB. Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. Nature. 2008 Mar 06; 452(7183):120. PMID: 18322536.
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  90. Cotta-de-Almeida V, Westerberg L, Maillard MH, Onaldi D, Wachtel H, Meelu P, Chung UI, Xavier R, Alt FW, Snapper SB. Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15424-9. PMID: 17878299; PMCID: PMC2000553.
  91. Maillard MH, Snapper SB. Teaching tolerance with a probiotic antigen delivery system. Gastroenterology. 2007 Aug; 133(2):706-9. PMID: 17681187.
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  92. Nguyen DD, Maillard MH, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB. Lymphocyte-dependent and Th2 cytokine-associated colitis in mice deficient in Wiskott-Aldrich syndrome protein. Gastroenterology. 2007 Oct; 133(4):1188-97. PMID: 17764675; PMCID: PMC2048975.
  93. Maillard MH, Cotta-de-Almeida V, Takeshima F, Nguyen DD, Michetti P, Nagler C, Bhan AK, Snapper SB. The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells. J Exp Med. 2007 Feb 19; 204(2):381-91. PMID: 17296786; PMCID: PMC2118715.
  94. Dewey RA, Avedillo Díez I, Ballmaier M, Filipovich A, Greil J, Güngör T, Happel C, Maschan A, Noyan F, Pannicke U, Schwarz K, Snapper S, Welte K, Klein C. Retroviral WASP gene transfer into human hematopoietic stem cells reconstitutes the actin cytoskeleton in myeloid progeny cells differentiated in vitro. Exp Hematol. 2006 Sep; 34(9):1161-9. PMID: 16939809.
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  95. Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE. Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival. Mol Cell Biol. 2005 Dec; 25(24):11145-55. PMID: 16314534; PMCID: PMC1316981.
  96. Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB, Illges H. A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis. Eur J Immunol. 2005 Oct; 35(10):3064-73. PMID: 16180250.
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  97. Stamm LM, Pak MA, Morisaki JH, Snapper SB, Rottner K, Lommel S, Brown EJ. Role of the WASP family proteins for Mycobacterium marinum actin tail formation. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14837-42. PMID: 16199520; PMCID: PMC1239894.
  98. Gallego MD, de la Fuente MA, Anton IM, Snapper S, Fuhlbrigge R, Geha RS. WIP and WASP play complementary roles in T cell homing and chemotaxis to SDF-1alpha. Int Immunol. 2006 Feb; 18(2):221-32. PMID: 16141245.
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  99. Snapper SB, Meelu P, Nguyen D, Stockton BM, Bozza P, Alt FW, Rosen FS, von Andrian UH, Klein C. WASP deficiency leads to global defects of directed leukocyte migration in vitro and in vivo. J Leukoc Biol. 2005 Jun; 77(6):993-8. PMID: 15774550.
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  100. Manchanda N, Lyubimova A, Ho HY, James MF, Gusella JF, Ramesh N, Snapper SB, Ramesh V. The NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function. J Biol Chem. 2005 Apr 01; 280(13):12517-22. PMID: 15699051.
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  101. Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA. A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell. 2005 Jan 21; 17(2):181-91. PMID: 15664188.
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  102. Kowalski JR, Egile C, Gil S, Snapper SB, Li R, Thomas SM. Cortactin regulates cell migration through activation of N-WASP. J Cell Sci. 2005 Jan 01; 118(Pt 1):79-87. PMID: 15585574.
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  103. Hokama A, Mizoguchi E, Sugimoto K, Shimomura Y, Tanaka Y, Yoshida M, Rietdijk ST, de Jong YP, Snapper SB, Terhorst C, Blumberg RS, Mizoguchi A. Induced reactivity of intestinal CD4(+) T cells with an epithelial cell lectin, galectin-4, contributes to exacerbation of intestinal inflammation. Immunity. 2004 Jun; 20(6):681-93. PMID: 15189734.
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  104. Ally S, Sauer NJ, Loureiro JJ, Snapper SB, Gertler FB, Goldberg MB. Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Cell Microbiol. 2004 Apr; 6(4):355-66. PMID: 15009027.
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  105. Rivera GM, Briceño CA, Takeshima F, Snapper SB, Mayer BJ. Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization. Curr Biol. 2004 Jan 06; 14(1):11-22. PMID: 14711409.
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  106. Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40. PMID: 14645152.
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  107. Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP. Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology. 2003 Dec; 110(4):519-26. PMID: 14632651; PMCID: PMC1783078.
  108. Cotta-de-Almeida V, Schonhoff S, Shibata T, Leiter A, Snapper SB. A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res. 2003 Sep; 13(9):2190-4. PMID: 12915491; PMCID: PMC403727.
  109. Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15; 22(14):3602-12. PMID: 12853475; PMCID: PMC165620.
  110. Lacout C, Haddad E, Sabri S, Svinarchouk F, Garçon L, Capron C, Foudi A, Mzali R, Snapper SB, Louache F, Vainchenker W, Duménil D. A defect in hematopoietic stem cell migration explains the nonrandom X-chromosome inactivation in carriers of Wiskott-Aldrich syndrome. Blood. 2003 Aug 15; 102(4):1282-9. PMID: 12730112.
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  111. Snapper SB, Rosen FS. A family of WASPs. N Engl J Med. 2003 Jan 23; 348(4):350-1. PMID: 12540651.
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  112. Klein C, Nguyen D, Liu CH, Mizoguchi A, Bhan AK, Miki H, Takenawa T, Rosen FS, Alt FW, Mulligan RC, Snapper SB. Gene therapy for Wiskott-Aldrich syndrome: rescue of T-cell signaling and amelioration of colitis upon transplantation of retrovirally transduced hematopoietic stem cells in mice. Blood. 2003 Mar 15; 101(6):2159-66. PMID: 12433691.
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  113. Krawczyk C, Oliveira-dos-Santos A, Sasaki T, Griffiths E, Ohashi PS, Snapper S, Alt F, Penninger JM. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002 Mar; 16(3):331-43. PMID: 11911819.
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  114. Shibata T, Takeshima F, Chen F, Alt FW, Snapper SB. Cdc42 facilitates invasion but not the actin-based motility of Shigella. Curr Biol. 2002 Feb 19; 12(4):341-5. PMID: 11864577.
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  115. Zou Z, Horowitz LF, Montmayeur JP, Snapper S, Buck LB. Genetic tracing reveals a stereotyped sensory map in the olfactory cortex. Nature. 2001 Nov 08; 414(6860):173-9. PMID: 11700549.
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  116. Alrutz MA, Srivastava A, Wong KW, D'Souza-Schorey C, Tang M, Ch'Ng LE, Snapper SB, Isberg RR. Efficient uptake of Yersinia pseudotuberculosis via integrin receptors involves a Rac1-Arp 2/3 pathway that bypasses N-WASP function. Mol Microbiol. 2001 Nov; 42(3):689-703. PMID: 11722735.
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  117. Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904. PMID: 11584271.
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  118. Westerberg L, Greicius G, Snapper SB, Aspenström P, Severinson E. Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes. Blood. 2001 Aug 15; 98(4):1086-94. PMID: 11493455.
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  119. Dao T, Exley M, Mehal WZ, Tahir SM, Snapper S, Taniguchi M, Balk SP, Crispe IN. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol. 2001 Mar 01; 166(5):3090-7. PMID: 11207260.
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  120. Krawczyk C, Bachmaier K, Sasaki T, Jones RG, Snapper SB, Bouchard D, Kozieradzki I, Ohashi PS, Alt FW, Penninger JM. Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. Immunity. 2000 Oct; 13(4):463-73. PMID: 11070165.
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  121. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28. PMID: 10889161.
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  122. Bauch A, Alt FW, Crabtree GR, Snapper SB. The cytoskeleton in lymphocyte signaling. Adv Immunol. 2000; 75:89-114. PMID: 10879282.
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  123. Zeng D, Gazit G, Dejbakhsh-Jones S, Balk SP, Snapper S, Taniguchi M, Strober S. Heterogeneity of NK1.1+ T cells in the bone marrow: divergence from the thymus. J Immunol. 1999 Nov 15; 163(10):5338-45. PMID: 10553057.
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  124. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med. 1999 Nov 01; 190(9):1215-26. PMID: 10544194; PMCID: PMC2195676.
  125. Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans. 1999 Aug; 27(4):624-9. PMID: 10917654.
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  126. Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15; 283(5400):393-7. PMID: 9888855.
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  127. Snapper SB, Rosen FS. The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. Annu Rev Immunol. 1999; 17:905-29. PMID: 10358777.
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  128. Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity. 1998 Jul; 9(1):81-91. PMID: 9697838.
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  129. Snapper SB, Syngal S, Friedman LS. Ulcerative colitis and colon cancer: more controversy than clarity. Dig Dis. 1998 Mar-Apr; 16(2):81-7. PMID: 9571373.
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  130. Barletta RG, Kim DD, Snapper SB, Bloom BR, Jacobs WR. Identification of expression signals of the mycobacteriophages Bxb1, L1 and TM4 using the Escherichia-Mycobacterium shuttle plasmids pYUB75 and pYUB76 designed to create translational fusions to the lacZ gene. J Gen Microbiol. 1992 Jan; 138(1):23-30. PMID: 1556552.
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  131. Jacobs WR, Kalpana GV, Cirillo JD, Pascopella L, Snapper SB, Udani RA, Jones W, Barletta RG, Bloom BR. Genetic systems for mycobacteria. Methods Enzymol. 1991; 204:537-55. PMID: 1658570.
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  132. Snapper SB, Melton RE, Mustafa S, Kieser T, Jacobs WR. Isolation and characterization of efficient plasmid transformation mutants of Mycobacterium smegmatis. Mol Microbiol. 1990 Nov; 4(11):1911-9. PMID: 2082148.
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  133. Jacobs WR, Snapper SB, Lugosi L, Bloom BR. Development of BCG as a recombinant vaccine vehicle. Curr Top Microbiol Immunol. 1990; 155:153-60. PMID: 2407431.
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  134. Jacobs WR, Snapper SB, Tuckman M, Bloom BR. Mycobacteriophage vector systems. Rev Infect Dis. 1989 Mar-Apr; 11 Suppl 2:S404-10. PMID: 2652256.
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  135. Bloom BR, Salgame P, Mehra V, Kato H, Modlin R, Rea T, Brennan P, Convit J, Lugozi L, Snapper S, et al. Vaccine development. On relating immunology to the Third World: some studies on leprosy. Immunol Suppl. 1989; 2:87-9; discussion 91-2. PMID: 2680926.
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  136. Jacobs WR, Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR. Development of genetic systems for the mycobacteria. Acta Leprol. 1989; 7 Suppl 1:203-7. PMID: 2503991.
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  137. Snapper SB, Lugosi L, Jekkel A, Melton RE, Kieser T, Bloom BR, Jacobs WR. Lysogeny and transformation in mycobacteria: stable expression of foreign genes. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):6987-91. PMID: 2842799; PMCID: PMC282104.
  138. Davidson A, Chien N, Frank L, Halpern R, Snapper S, Zupko K, Diamond B. Use of anti-idiotypic antibodies to explore genetic mechanisms of production of anti-DNA antibodies. Cell Immunol. 1986 Apr 15; 99(1):44-52. PMID: 3489565.
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  139. Lechan RM, Snapper SB, Jacobson S, Jackson IM. The distribution of thyrotropin-releasing hormone (TRH) in the rhesus monkey spinal cord. Peptides. 1984; 5 Suppl 1:185-94. PMID: 6435101.
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  140. Lechan RM, Snapper SB, Jackson IM. Evidence that spinal cord thyrotropin-releasing hormone is independent of the paraventricular nucleus. Neurosci Lett. 1983 Dec 23; 43(1):61-5. PMID: 6199695.
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