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Last Name

profileTimothy William Clark, Ph.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Room 219
65 Landsdowne St
Cambridge MA 02139
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U01HG009452     (CLARK, TIMOTHY W)Sep 28, 2016 - Jun 30, 2019
Argumentation and linked-metadata services for reproducible target validation
Role: Principal Investigator
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 Feb 06; 115(6):E1289-E1298. PMID: 29358399.
    View in: PubMed
  2. Hsu MC, Weber CN, Stavropoulos SW, Clark TW, Trerotola SO, Shlansky-Goldberg RD, Soulen MC, Nadolski GJ. Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes. World J Hepatol. 2017 Apr 28; 9(12):603-612. PMID: 28515846.
    View in: PubMed
  3. Gade TPF, Tucker E, Nakazawa MS, Hunt SJ, Wong W, Krock B, Weber CN, Nadolski GJ, Clark TWI, Soulen MC, Furth EE, Winkler JD, Amaravadi RK, Simon MC. Ischemia Induces Quiescence and Autophagy Dependence in Hepatocellular Carcinoma. Radiology. 2017 Jun; 283(3):702-710. PMID: 28253108.
    View in: PubMed
  4. Vesey AT, Jenkins WS, Irkle A, Moss A, Sng G, Forsythe RO, Clark T, Roberts G, Fletcher A, Lucatelli C, Rudd JH, Davenport AP, Mills NL, Al-Shahi Salman R, Dennis M, Whiteley WN, van Beek EJ, Dweck MR, Newby DE. 18F-Fluoride and 18F-Fluorodeoxyglucose Positron Emission Tomography After Transient Ischemic Attack or Minor Ischemic Stroke: Case-Control Study. Circ Cardiovasc Imaging. 2017 Mar; 10(3). PMID: 28292859.
    View in: PubMed
  5. Clark K, Chick JF, Reddy SN, Shin BJ, Nadolski GJ, Clark TW, Trerotola SO. Concurrent Central Venous Stent and Central Venous Access Device Placement Does Not Compromise Stent Patency or Catheter Function in Patients with Malignant Central Venous Obstruction. J Vasc Interv Radiol. 2017 Apr; 28(4):602-607. PMID: 28238580.
    View in: PubMed
  6. Clark TW, Watts MM, Kwan TW. Percutaneous Femoropopliteal Recanalization Using a Completely Transpedal/Transtibial Approach. Cardiovasc Intervent Radiol. 2016 Dec; 39(12):1750-1758. PMID: 27439623.
    View in: PubMed
  7. Chen JX, Maass D, Guzzo TJ, Bruce Malkowicz S, Wein AJ, Soulen MC, Clark TWI, Nadolski GJ, William Stavropoulos S. Tumor Growth Kinetics and Oncologic Outcomes of Patients Undergoing Active Surveillance for Residual Renal Tumor following Percutaneous Thermal Ablation. J Vasc Interv Radiol. 2016 Sep; 27(9):1397-1406. PMID: 27234485.
    View in: PubMed
  8. Hsu MC, Weber CN, Mohammed MA, Gade TP, Hunt S, Nadolski GJ, Clark TW. Thermal Changes during Rheolytic Mechanical Thrombectomy. J Vasc Interv Radiol. 2016 Jun; 27(6):905-12. PMID: 27103145.
    View in: PubMed
  9. Allen GI, Amoroso N, Anghel C, Balagurusamy V, Bare CJ, Beaton D, Bellotti R, Bennett DA, Boehme KL, Boutros PC, Caberlotto L, Caloian C, Campbell F, Chaibub Neto E, Chang YC, Chen B, Chen CY, Chien TY, Clark T, Das S, Davatzikos C, Deng J, Dillenberger D, Dobson RJ, Dong Q, Doshi J, Duma D, Errico R, Erus G, Everett E, Fardo DW, Friend SH, Fröhlich H, Gan J, St George-Hyslop P, Ghosh SS, Glaab E, Green RC, Guan Y, Hong MY, Huang C, Hwang J, Ibrahim J, Inglese P, Iyappan A, Jiang Q, Katsumata Y, Kauwe JS, Klein A, Kong D, Krause R, Lalonde E, Lauria M, Lee E, Lin X, Liu Z, Livingstone J, Logsdon BA, Lovestone S, Ma TW, Malhotra A, Mangravite LM, Maxwell TJ, Merrill E, Nagorski J, Namasivayam A, Narayan M, Naz M, Newhouse SJ, Norman TC, Nurtdinov RN, Oyang YJ, Pawitan Y, Peng S, Peters MA, Piccolo SR, Praveen P, Priami C, Sabelnykova VY, Senger P, Shen X, Simmons A, Sotiras A, Stolovitzky G, Tangaro S, Tateo A, Tung YA, Tustison NJ, Varol E, Vradenburg G, Weiner MW, Xiao G, Xie L, Xie Y, Xu J, Yang H, Zhan X, Zhou Y, Zhu F, Zhu H, Zhu S. Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease. Alzheimers Dement. 2016 Jun; 12(6):645-53. PMID: 27079753.
    View in: PubMed
  10. Wilkinson MD, Dumontier M, Aalbersberg IJ, Appleton G, Axton M, Baak A, Blomberg N, Boiten JW, da Silva Santos LB, Bourne PE, Bouwman J, Brookes AJ, Clark T, Crosas M, Dillo I, Dumon O, Edmunds S, Evelo CT, Finkers R, Gonzalez-Beltran A, Gray AJ, Groth P, Goble C, Grethe JS, Heringa J, 't Hoen PA, Hooft R, Kuhn T, Kok R, Kok J, Lusher SJ, Martone ME, Mons A, Packer AL, Persson B, Rocca-Serra P, Roos M, van Schaik R, Sansone SA, Schultes E, Sengstag T, Slater T, Strawn G, Swertz MA, Thompson M, van der Lei J, van Mulligen E, Velterop J, Waagmeester A, Wittenburg P, Wolstencroft K, Zhao J, Mons B. The FAIR Guiding Principles for scientific data management and stewardship. Sci Data. 2016 Mar 15; 3:160018. PMID: 26978244; PMCID: PMC4792175.
  11. Madoff DC, Gaba RC, Weber CN, Clark TW, Saad WE. Portal Venous Interventions: State of the Art. Radiology. 2016 Feb; 278(2):333-53. PMID: 26789601.
    View in: PubMed
  12. Ge BH, Guzzo TJ, Nadolski GJ, Soulen MC, Clark TW, Malkowicz SB, Wein AJ, Hunt SJ, Stavropoulos SW. Percutaneous Renal Cryoablation: Short-Axis Ice-Ball Margin as a Predictor of Outcome. J Vasc Interv Radiol. 2016 Mar; 27(3):403-9. PMID: 26755344.
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  13. Dariushnia SR, Haskal ZJ, Midia M, Martin LG, Walker TG, Kalva SP, Clark TW, Ganguli S, Krishnamurthy V, Saiter CK, Nikolic B. Quality Improvement Guidelines for Transjugular Intrahepatic Portosystemic Shunts. J Vasc Interv Radiol. 2016 Jan; 27(1):1-7. PMID: 26614596.
    View in: PubMed
  14. Chen JX, Guzzo TJ, Malkowicz SB, Soulen MC, Wein AJ, Clark TW, Nadolski GJ, Stavropoulos SW. Complication and Readmission Rates following Same-Day Discharge after Percutaneous Renal Tumor Ablation. J Vasc Interv Radiol. 2016 Jan; 27(1):80-6. PMID: 26547122.
    View in: PubMed
  15. Tom LM, Palevsky HI, Holsclaw DS, Trerotola SO, Dagli M, Mondschein JI, Stavropoulos SW, Soulen MC, Clark TW. Recurrent Bleeding, Survival, and Longitudinal Pulmonary Function following Bronchial Artery Embolization for Hemoptysis in a U.S. Adult Population. J Vasc Interv Radiol. 2015 Dec; 26(12):1806-13.e1. PMID: 26481824.
    View in: PubMed
  16. Clark TW, Redmond JW, Mantell MP, Nadolski GJ, Mondschein JI, Dowd MF, Dagli MS, Sudheendra D, Shlansky-Goldberg RD, Cohen RD. Initial Clinical Experience: Symmetric-Tip Dialysis Catheter with Helical Flow Characteristics Improves Patient Outcomes. J Vasc Interv Radiol. 2015 Oct; 26(10):1501-8. PMID: 26239895.
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  17. Weber CN, Nadolski GJ, White SB, Clark TW, Mondschein JI, Stavropoulos SW, Shlansky-Goldberg RD, Trerotola SO, Soulen MC. Long-Term Patency and Clinical Analysis of Expanded Polytetrafluoroethylene-Covered Transjugular Intrahepatic Portosystemic Shunt Stent Grafts. J Vasc Interv Radiol. 2015 Sep; 26(9):1257-65; quiz 1265. PMID: 25990133.
    View in: PubMed
  18. Yan Y, Sudheendra D, Dagli MS, William Stavropoulos S, Clark TW, Soulen MC, Mondschein JI, Shlansky-Goldberg RD, Trerotola SO. Effect of central venous angioplasty on hemodialysis access circuit flow: prospective study of 25 symptomatic patients. J Vasc Interv Radiol. 2015 Jul; 26(7):984-91. PMID: 25890685.
    View in: PubMed
  19. DePietro DM, Shlansky-Goldberg RD, Soulen MC, Stavropoulos SW, Mondschein JI, Dagli MS, Itkin M, Clark TW, Trerotola SO. Long-term outcomes of a benign biliary stricture protocol. J Vasc Interv Radiol. 2015 Jul; 26(7):1032-9. PMID: 25890686.
    View in: PubMed
  20. Clark TW, Isu G, Gallo D, Verdonck P, Morbiducci U. Comparison of symmetric hemodialysis catheters using computational fluid dynamics. J Vasc Interv Radiol. 2015 Feb; 26(2):252-9.e2. PMID: 25645414.
    View in: PubMed
  21. Starr J, Castro E, Crosas M, Dumontier M, Downs RR, Duerr R, Haak LL, Haendel M, Herman I, Hodson S, Hourclé J, Kratz JE, Lin J, Nielsen LH, Nurnberger A, Proell S, Rauber A, Sacchi S, Smith A, Taylor M, Clark T. Achieving human and machine accessibility of cited data in scholarly publications. PeerJ Comput Sci. 2015; 1. PMID: 26167542.
    View in: PubMed
  22. Clark T, Ciccarese PN, Goble CA. Micropublications: a semantic model for claims, evidence, arguments and annotations in biomedical communications. J Biomed Semantics. 2014; 5:28. PMID: 26261718; PMCID: PMC4530550.
  23. Merrill E, Corlosquet S, Ciccarese P, Clark T, Das S. Semantic Web repositories for genomics data using the eXframe platform. J Biomed Semantics. 2014; 5(Suppl 1 Proceedings of the Bio-Ontologies Spec Interest G):S3. PMID: 25093072; PMCID: PMC4108874.
  24. Das S, McCaffrey PG, Talkington MW, Andrews NA, Corlosquet S, Ivinson AJ, Clark T. Pain Research Forum: application of scientific social media frameworks in neuroscience. Front Neuroinform. 2014; 8:21. PMID: 24653693; PMCID: PMC3949323.
  25. Leontiev O, Shlansky-Goldberg RD, Stavropoulos SW, Mondschein JI, Itkin M, Clark TW, Trerotola SO. Should all inflow stenoses be treated in failing autogenous hemodialysis fistulae? J Vasc Interv Radiol. 2014 Apr; 25(4):542-7. PMID: 24508347.
    View in: PubMed
  26. Clark TW, McCann JW, Salsamendi J, Dowd MF, Hajdu CH. Optimizing needle direction during transjugular liver biopsy provides superior biopsy specimens. Cardiovasc Intervent Radiol. 2014 Dec; 37(6):1540-5. PMID: 24352863.
    View in: PubMed
  27. Agarwal A, Mantell M, Cohen R, Yan Y, Trerotola S, Clark TW. Outcomes of single-stage compared to two-stage basilic vein transposition fistulae. Semin Dial. 2014 May-Jun; 27(3):298-302. PMID: 24320222.
    View in: PubMed
  28. Yan Y, Clark TW, Mondschein JI, Shlansky-Goldberg RD, Dagli MS, Soulen MC, Stavropoulos SW, Sudheendra D, Mantell MP, Cohen RD, Kobrin S, Chittams JL, Trerotola SO. Outcomes of percutaneous interventions in transposed hemodialysis fistulas compared with nontransposed fistulas and grafts. J Vasc Interv Radiol. 2013 Dec; 24(12):1765-72; quiz 1773. PMID: 24409470.
    View in: PubMed
  29. Ciccarese P, Soiland-Reyes S, Belhajjame K, Gray AJ, Goble C, Clark T. PAV ontology: provenance, authoring and versioning. J Biomed Semantics. 2013 Nov 22; 4(1):37. PMID: 24267948; PMCID: PMC4177195.
  30. Nadolski G, Mondschein JI, Shlansky-Goldberg RD, Stavropoulos SW, Soulen MC, Dagli MS, Clark TW, Trerotola SO. Diagnostic yield of transjugular liver biopsy samples to evaluate for infectious etiology of liver dysfunction in bone marrow transplant recipients. Cardiovasc Intervent Radiol. 2014 Apr; 37(2):471-5. PMID: 23760757.
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  31. McFarland KN, Das S, Sun TT, Leyfer D, Kim MO, Xia E, Sangrey GR, Kuhn A, Luthi-Carter R, Clark TW, Sadri-Vakili G, Cha JH. Genome-wide increase in histone H2A ubiquitylation in a mouse model of Huntington's disease. J Huntingtons Dis. 2013; 2(3):263-77. PMID: 25062675.
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  32. Clark T and Goble C. Encyclopedia of Systems Biology, Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho & Hiroki Yokota eds. The World-Wide Web. 2013.
  33. Clark T. Encyclopedia of Systems Biology. Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho & Hiroki Yokota (eds.),. Collaborative and distributed biomedical application. 2013.
  34. Cases M, Furlong LI, Albanell J, Altman RB, Bellazzi R, Boyer S, Brand A, Brookes AJ, Brunak S, Clark T, Gea J, Ghazal P, Graf N, Guigó R, Klein TE, López-Bigas N, Maojo V, Mons B, Musen M, Oliveira JL, Rowe A, Ruch P, Shabo A, Shortliffe EH, Valencia A, van der Lei J, Mayer MA, Sanz F. Improving data and knowledge management to better integrate health care and research. Journal of Internal Medicine. 2013; 4(274):321-8.
  35. Ciccarese P, Soiland-Reyes S, Clark T . Web Annotation as a First-Class Object. IEEE Internet Computing. 2013; (Nov/Dec).
  36. McFarland KN, Das S, Sun TT, Leyfer D, Xia E, Sangrey GR, Kuhn A, Luthi-Carter R, Clark TW, Sadri-Vakili G, Cha JH. Genome-wide histone acetylation is altered in a transgenic mouse model of Huntington's disease. PLoS One. 2012; 7(7):e41423. PMID: 22848491; PMCID: PMC3407195.
  37. Ciccarese P, Ocana M, Clark T. Open semantic annotation of scientific publications using DOMEO. J Biomed Semantics. 2012 Apr 24; 3 Suppl 1:S1. PMID: 22541592; PMCID: PMC3337259.
  38. Bandrowski AE, Cachat J, Li Y, Müller HM, Sternberg PW, Ciccarese P, Clark T, Marenco L, Wang R, Astakhov V, Grethe JS, Martone ME. A hybrid human and machine resource curation pipeline for the Neuroscience Information Framework. Database (Oxford). 2012; 2012:bas005. PMID: 22434839; PMCID: PMC3308161.
  39. Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H, Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G, Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL, Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A, Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA, Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W. Toward interoperable bioscience data. Nat Genet. 2012 Jan 27; 44(2):121-6. PMID: 22281772; PMCID: PMC3428019.
  40. Bourne P, Clark T, Dale R, de Waard A, Herman I, Hovy E, Shotton D. Improving Future Research Communication and e-Scholarship: A Summary of Findings. Informatik Spectrum. 2012; 1(35):56-57.
  41. Ciccarese P, Shotton S, Peroni S, Clark T . CITO+SWAN: The Web Semantics of Bibliographic Records, Citations, Evidence and Discourse Relationships. Semantic Web Journal. 2012.
  42. Sinha AU, Merrill E, Armstrong SA, Clark TW, Das S. eXframe: reusable framework for storage, analysis and visualization of genomics experiments. BMC Bioinformatics. 2011 Nov 21; 12:452. PMID: 22103807; PMCID: PMC3235155.
  43. Ciccarese P, Ocana M, Garcia Castro LJ, Das S, Clark T. An open annotation ontology for science on web 3.0. J Biomed Semantics. 2011 May 17; 2 Suppl 2:S4. PMID: 21624159; PMCID: PMC3102893.
  44. Luciano JS, Andersson B, Batchelor C, Bodenreider O, Clark T, Denney CK, Domarew C, Gambet T, Harland L, Jentzsch A, Kashyap V, Kos P, Kozlovsky J, Lebo T, Marshall SM, McCusker JP, McGuinness DL, Ogbuji C, Pichler E, Powers RL, Prud'hommeaux E, Samwald M, Schriml L, Tonellato PJ, Whetzel PL, Zhao J, Stephens S, Dumontier M. The Translational Medicine Ontology and Knowledge Base: driving personalized medicine by bridging the gap between bench and bedside. J Biomed Semantics. 2011 May 17; 2 Suppl 2:S1. PMID: 21624155; PMCID: PMC3102889.
  45. Bourne P, Clark T, Dale R, de Waard A, Herman I, Hovy E, Shotton D. The Future of Research Communication and e-Scholarship. Dagstuhl Reports. 2011; 8(1).
  46. Clark T, De Waard A, Herman I, Hovy E. The Future of Research Communication. Dagstuhl Rep. 2011; 1(8):29-52. PMID: 26317061.
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  47. Das S, Girard L, Green T, Weitzman L, Lewis-Bowen A, Clark T. Building biomedical web communities using a semantically aware content management system. Brief Bioinform. 2009 Mar; 10(2):129-38. PMID: 19060302.
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  48. Benn CL, Sun T, Sadri-Vakili G, McFarland KN, DiRocco DP, Yohrling GJ, Clark TW, Bouzou B, Cha JH. Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner. J Neurosci. 2008 Oct 15; 28(42):10720-33. PMID: 18923047; PMCID: PMC2586288.
  49. Ciccarese P, Wu E, Wong G, Ocana M, Kinoshita J, Ruttenberg A, Clark T. The SWAN biomedical discourse ontology. J Biomed Inform. 2008 Oct; 41(5):739-51. PMID: 18583197; PMCID: PMC4536833.
  50. Clark T. Knowledge Integration in Biomedicine: Technology and Community. Brief Bioinform. 2007 May 25. PMID: 17526592.
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  51. Clark T, Kinoshita J. Alzforum and SWAN: the present and future of scientific web communities. Brief Bioinform. 2007 May; 8(3):163-71. PMID: 17510163.
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  52. Lam HY, Marenco L, Clark T, Gao Y, Kinoshita J, Shepherd G, Miller P, Wu E, Wong GT, Liu N, Crasto C, Morse T, Stephens S, Cheung KH. AlzPharm: integration of neurodegeneration data using RDF. BMC Bioinformatics. 2007 May 09; 8 Suppl 3:S4. PMID: 17493287; PMCID: PMC1892101.
  53. Ruttenberg A, Clark T, Bug W, Samwald M, Bodenreider O, Chen H, Doherty D, Forsberg K, Gao Y, Kashyap V, Kinoshita J, Luciano J, Marshall MS, Ogbuji C, Rees J, Stephens S, Wong GT, Wu E, Zaccagnini D, Hongsermeier T, Neumann E, Herman I, Cheung KH. Advancing translational research with the Semantic Web. BMC Bioinformatics. 2007 May 09; 8 Suppl 3:S2. PMID: 17493285; PMCID: PMC1892099.
  54. Sadri-Vakili G, Bouzou B, Benn CL, Kim MO, Chawla P, Overland RP, Glajch KE, Xia E, Qiu Z, Hersch SM, Clark TW, Yohrling GJ, Cha JH. Histones associated with downregulated genes are hypo-acetylated in Huntington's disease models. Hum Mol Genet. 2007 Jun 01; 16(11):1293-306. PMID: 17409194.
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  55. Cantuti-Castelvetri I, Keller-McGandy C, Bouzou B, Asteris G, Clark TW, Frosch MP, Standaert DG. Effects of gender on nigral gene expression and parkinson disease. Neurobiol Dis. 2007 Jun; 26(3):606-14. PMID: 17412603; PMCID: PMC2435483.
  56. Kinoshita J, Clark T. Alzforum. Methods Mol Biol. 2007; 401:365-81. PMID: 18368375.
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  57. Gao Y, Kinoshita J, Wu E, Miller E, Lee R, Seaborne A, Cayzer S, Clark T. SWAN: A Distributed Knowledge Infrastructure for Alzheimer Disease Research. Journal of Web Semantics. 2006; 3(4):222-228.
  58. Clark T, Martin S, Liefeld T. Globally distributed object identification for biological knowledgebases. Brief Bioinform. 2004 Mar; 5(1):59-70. PMID: 15153306.
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  59. Ficenec D, Osborne M, Pradines J, Richards D, Felciano R, Cho RJ, Chen RO, Liefeld T, Owen J, Ruttenberg A, Reich C, Horvath J, Clark T. Computational knowledge integration in biopharmaceutical research. Brief Bioinform. 2003 Sep; 4(3):260-78. PMID: 14582520.
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  60. Clark T. Identity and interoperability in bioinformatics. Brief Bioinform. 2003 Mar; 4(1):4-6. PMID: 12715829.
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  61. Zhou G, Chen J, Lee S, Clark T, Rowley JD, Wang SM. The pattern of gene expression in human CD34(+) stem/progenitor cells. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13966-71. PMID: 11717454; PMCID: PMC61150.
  62. Chen J, Rowley DA, Clark T, Lee S, Zhou G, Beck C, Rowley JD, Wang SM. The pattern of gene expression in mouse Gr-1(+) myeloid progenitor cells. Genomics. 2001 Oct; 77(3):149-62. PMID: 11597140.
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  63. Lee S, Zhou G, Clark T, Chen J, Rowley JD, Wang SM. The pattern of gene expression in human CD15+ myeloid progenitor cells. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3340-5. PMID: 11248080; PMCID: PMC30655.
  64. Preisser EL, Kefer JY, Lawrence JD, Clark TW. Vernal pool conservation in connecticut: an assessment and recommendations. Environ Manage. 2000 Nov; 26(5):503-13. PMID: 10982728.
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  65. Clark TW, Elsom KO, Montgomery EH, Ipsen J. Clinical and biological observations on working men. Arch Environ Health. 1969 Nov; 19(5):700-11. PMID: 5350441.
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  66. Das S, McCaffrey PG, Talkington MWT, Andrews NA, Corlosquet S, Ivinson AJ, Clark T. Pain Research Forum: Application of Scientific Social Media Frameworks in Neuroscience. Frontiers in Neuroinformatics.
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