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Helen A. Christou, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EY024114 (INDER, TERRIE E) Jan 1, 2015 - Jun 30, 2015
    NIH
    The Pathomechanistic Role of Endothelial IDO in proliferative Retinopathy
    Role: Principal Investigator
  2. R01HL116573 (CHRISTOU, HELEN) Sep 1, 2014 - Jul 31, 2019
    NIH
    Vascular smooth muscle cell phenotypic switching in Pulmonary Hypertension
    Role: Principal Investigator
  3. K08HL003917 (CHRISTOU, HELEN) Jan 15, 2000 - Dec 31, 2005
    NIH
    THE ROLE OF CARBON MONOXIDE IN VASCULAR HOMEOSTASIS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Spyropoulos F, Michael Z, Finander B, Vitali S, Kosmas K, Zymaris P, Kalish BT, Kourembanas S, Christou H. Acetazolamide Improves Right Ventricular Function and Metabolic Gene Dysregulation in Experimental Pulmonary Arterial Hypertension. Front Cardiovasc Med. 2021; 8:662870. PMID: 34222363.
    Citations:    
  2. Hansmann G, Christou H, Koestenberger M, Sallmon H. Off-label use of PAH-targeted medications approved for adults and their financial coverage by health insurances are vital for children with pulmonary hypertension. Eur J Clin Invest. 2021 Aug; 51(8):e13571. PMID: 33834481.
    Citations:    Fields:    
  3. Christou H, Michael Z, Spyropoulos F, Chen Y, Rong D, Khalil RA. Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol. 2021 06 01; 320(6):R835-R850. PMID: 33826428.
    Citations:    Fields:    Translation:Animals
  4. Niccum M, Spyropoulos F, Levin JC, Petty CR, Mullen MP, Christou H. Lower oxygen saturation targets in preterm infants are not associated with increased rates of pulmonary hypertension. J Neonatal Perinatal Med. 2021 Mar 11. PMID: 33720854.
    Citations:    Fields:    
  5. Papathanasiou AE, Spyropoulos F, Michael Z, Joung KE, Briana DD, Malamitsi-Puchner A, Mantzoros CS, Christou H. Adipokines and Metabolic Regulators in Human and Experimental Pulmonary Arterial Hypertension. Int J Mol Sci. 2021 Feb 01; 22(3). PMID: 33535425.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Spyropoulos F, Vitali SH, Touma M, Rose CD, Petty CR, Levy P, Kourembanas S, Christou H. Echocardiographic markers of pulmonary hemodynamics and right ventricular hypertrophy in rat models of pulmonary hypertension. Pulm Circ. 2020 Apr-Jun; 10(2):2045894020910976. PMID: 32537128.
    Citations: 2     
  7. Joung KE, Clausen D, Herdt A, Presti A, Snyder R, Peters C, Christou H, Mantzoros CS. Association of circulating FGF-21 levels in the first week of life and postnatal growth in hospitalized preterm infants. Metabol Open. 2020 Mar; 5:100030. PMID: 32812922.
    Citations:    
  8. Basak A, Munschauer M, Lareau CA, Montbleau KE, Ulirsch JC, Hartigan CR, Schenone M, Lian J, Wang Y, Huang Y, Wu X, Gehrke L, Rice CM, An X, Christou HA, Mohandas N, Carr SA, Chen JJ, Orkin SH, Lander ES, Sankaran VG. Control of human hemoglobin switching by LIN28B-mediated regulation of BCL11A translation. Nat Genet. 2020 02; 52(2):138-145. PMID: 31959994.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  9. DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou AE, Christou H, Mantzoros CS. GLYCOSYLATED FIBRONECTIN AND INHIBIN ARE LOWER AND ANTI-MÜLLERIAN HORMONE IS HIGHER IN UMBILICAL CORD BLOOD WHEN MOTHERS HAVE PREECLAMPSIA. Endocr Pract. 2020 Mar; 26(3):318-327. PMID: 31859547.
    Citations:    Fields:    Translation:Humans
  10. Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H. Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 10; 61(4):512-524. PMID: 30951642.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. DiPrisco B, Kumar A, Kalra B, Savjani GV, Michael Z, Farr O, Papathanasiou AE, Christou H, Mantzoros C. Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: Levels in umbilical cord blood and associations with birth weight and length. Metabolism. 2019 11; 100:153959. PMID: 31401027.
    Citations: 6     Fields:    Translation:HumansCells
  12. Lithoxopoulou M, Rallis D, Christou H, Goutsiou E, Varaklioti A, Karagianni P, Tsakalidis C, Domeyer P, Kuriakeli G, Soubasi V. Early caloric deprivation in preterm infants affects Bayley-III scales performance at 18-24 months of corrected age. Res Dev Disabil. 2019 Aug; 91:103429. PMID: 31272067.
    Citations:    Fields:    Translation:Humans
  13. Michael Z, Spyropoulos F, Ghanta S, Christou H. Bronchopulmonary Dysplasia: An Update of Current Pharmacologic Therapies and New Approaches. Clin Med Insights Pediatr. 2018; 12:1179556518817322. PMID: 30574005.
    Citations: 13     
  14. Liang X, Gupta K, Quintero JR, Cernadas M, Kobzik L, Christou H, Pier GB, Owen CA, Çataltepe S. Macrophage FABP4 is required for neutrophil recruitment and bacterial clearance in Pseudomonas aeruginosa pneumonia. FASEB J. 2019 03; 33(3):3562-3574. PMID: 30462529.
    Citations: 7     Fields:    Translation:AnimalsCells
  15. Scheid A, Borriello F, Pietrasanta C, Christou H, Diray-Arce J, Pettengill MA, Joshi S, Li N, Bergelson I, Kollmann T, Dowling DJ, Levy O. Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. Front Immunol. 2018; 9:29. PMID: 29416539.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  16. Angelidou A, Michael Z, Hotz A, Friedman K, Emani S, LaRovere K, Christou H. Is There More to Zika? Complex Cardiac Disease in a Case of Congenital Zika Syndrome. Neonatology. 2018; 113(2):177-182. PMID: 29248924.
    Citations: 7     Fields:    Translation:HumansCells
  17. Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 02; 364(2):258-274. PMID: 29212831.
    Citations: 4     Fields:    Translation:AnimalsCells
  18. Joung KE, Cataltepe SU, Michael Z, Christou H, Mantzoros CS. Cord Blood Adipocyte Fatty Acid-Binding Protein Levels Correlate With Gestational Age and Birth Weight in Neonates. J Clin Endocrinol Metab. 2017 05 01; 102(5):1606-1613. PMID: 28324040.
    Citations: 4     Fields:    Translation:Humans
  19. Christou H, Dookeran N, Haas A, Di Frances C, Emans SJ, Milstein ME, Kram KE, Seely EW. Establishing Effective Mentoring Networks: Rationale and Strategies. MedEdPORTAL. 2017 Apr 18; 13:10571. PMID: 30800773.
    Citations:    Fields:    
  20. Joung KE, Burris HH, Van Marter LJ, McElrath TF, Michael Z, Tabatabai P, Litonjua AA, Weiss ST, Christou H. Vitamin D and bronchopulmonary dysplasia in preterm infants. J Perinatol. 2016 10; 36(10):878-82. PMID: 27467562.
    Citations: 8     Fields:    Translation:Humans
  21. Christou H, Dizon ML, Farrow KN, Jadcherla SR, Leeman KT, Maheshwari A, Rubin LP, Stansfield BK, Rowitch DH. Sustaining careers of physician-scientists in neonatology and pediatric critical care medicine: formulating supportive departmental policies. Pediatr Res. 2016 11; 80(5):635-640. PMID: 27434118.
    Citations: 1     Fields:    Translation:Humans
  22. Joung KE, Park KH, Filippaios A, Dincer F, Christou H, Mantzoros CS. Cord blood irisin levels are positively correlated with birth weight in newborn infants. Metabolism. 2015 Nov; 64(11):1507-14. PMID: 26303870.
    Citations: 8     Fields:    Translation:Humans
  23. Lin T, Maita D, Thundivalappil SR, Riley FE, Hambsch J, Van Marter LJ, Christou HA, Berra L, Fagan S, Christiani DC, Warren HS. Hemopexin in severe inflammation and infection: mouse models and human diseases. Crit Care. 2015 Apr 15; 19:166. PMID: 25888135.
    Citations: 12     Fields:    Translation:HumansAnimals
  24. Tsoyi K, Geldart AM, Christou H, Liu X, Chung SW, Perrella MA. Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol. 2015 Jan; 97(1):171-80. PMID: 25351511.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Joung KE, Christou H, Park KH, Mantzoros CS. Cord blood levels of osteopontin as a phenotype marker of gestational age and neonatal morbidities. Obesity (Silver Spring). 2014 May; 22(5):1317-24. PMID: 24123979.
    Citations: 1     Fields:    Translation:Humans
  26. Burris HH, Van Marter LJ, McElrath TF, Tabatabai P, Litonjua AA, Weiss ST, Christou H. Vitamin D status among preterm and full-term infants at birth. Pediatr Res. 2014 Jan; 75(1-1):75-80. PMID: 24121425.
    Citations: 25     Fields:    Translation:Humans
  27. Xiao Y, Christou H, Liu L, Visner G, Mitsialis SA, Kourembanas S, Liu H. Endothelial indoleamine 2,3-dioxygenase protects against development of pulmonary hypertension. Am J Respir Crit Care Med. 2013 Aug 15; 188(4):482-91. PMID: 23822766.
    Citations: 22     Fields:    Translation:AnimalsCells
  28. Ghanta S, Leeman KT, Christou H. An update on pharmacologic approaches to bronchopulmonary dysplasia. Semin Perinatol. 2013 Apr; 37(2):115-23. PMID: 23582966.
    Citations: 12     Fields:    Translation:Humans
  29. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. . 2012 May 01; 302(9):L875-90. PMID: 22287610.
    Citations: 10     Translation:AnimalsCells
  30. Tropea K, Christou H. Current pharmacologic approaches for prevention and treatment of bronchopulmonary dysplasia. Int J Pediatr. 2012; 2012:598606. PMID: 22262977.
    Citations: 4     
  31. Brenninkmeijer L, Kuehl C, Geldart AM, Arons E, Christou H. Heme oxygenase-1 does not mediate the effects of extracellular acidosis on vascular smooth muscle cell proliferation, migration, and susceptibility to apoptosis. J Vasc Res. 2011; 48(4):285-96. PMID: 21273783.
    Citations: 8     Fields:    Translation:AnimalsCells
  32. Christou HA, Khalil RA. Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol. 2010 Nov; 56(5):471-4. PMID: 20881609.
    Citations: 4     Fields:    Translation:HumansAnimals
  33. Mam V, Tanbe AF, Vitali SH, Arons E, Christou HA, Khalil RA. Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther. 2010 Feb; 332(2):455-62. PMID: 19915069.
    Citations: 28     Fields:    Translation:Animals
  34. Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009 Jun 19; 4(6):e5978. PMID: 19543386.
    Citations: 14     Fields:    Translation:AnimalsCells
  35. Aslam M, Christou HA. Intrauterine closure of the ductus arteriosus: implications for the neonatologist. Am J Perinatol. 2009 Aug; 26(7):473-8. PMID: 19263336.
    Citations: 1     Fields:    Translation:Humans
  36. Guan J, Wu X, Arons E, Christou H. The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells. J Cell Biochem. 2008 Dec 01; 105(5):1298-306. PMID: 18846504.
    Citations: 11     Fields:    Translation:AnimalsCells
  37. Waisbren SE, Bowles H, Hasan T, Zou KH, Emans SJ, Goldberg C, Gould S, Levine D, Lieberman E, Loeken M, Longtine J, Nadelson C, Patenaude AF, Quinn D, Randolph AG, Solet JM, Ullrich N, Walensky R, Weitzman P, Christou H. Gender differences in research grant applications and funding outcomes for medical school faculty. J Womens Health (Larchmt). 2008 Mar; 17(2):207-14. PMID: 18321172.
    Citations: 30     Fields:    Translation:Humans
  38. Baveja R, Christou H. Pharmacological strategies in the prevention and management of bronchopulmonary dysplasia. Semin Perinatol. 2006 Aug; 30(4):209-18. PMID: 16860161.
    Citations: 15     Fields:    Translation:Humans
  39. Anttila V, Christou H, Hagino I, Iwata Y, Mettler BA, Fernandez-Gonzalez A, Zurakowski D, Jonas RA. Cerebral endothelial nitric oxide synthase expression is reduced after very-low-flow bypass. Ann Thorac Surg. 2006 Jun; 81(6):2202-6. PMID: 16731155.
    Citations: 3     Fields:    Translation:Animals
  40. Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S. PMID: 16373841.
    Citations: 2     Fields:    Translation:Animals
  41. Christou H, Brodsky D. Lung injury and bronchopulmonary dysplasia in newborn infants. J Intensive Care Med. 2005 Mar-Apr; 20(2):76-87. PMID: 15855220.
    Citations: 7     Fields:    Translation:HumansAnimals
  42. Christou H, Bailey N, Kluger MS, Mitsialis SA, Kourembanas S. Extracellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells. . 2005 Jun; 288(6):H2647-52. PMID: 15681695.
    Citations: 9     Translation:AnimalsCells
  43. Brodsky D, Christou H. Current concepts in intrauterine growth restriction. J Intensive Care Med. 2004 Nov-Dec; 19(6):307-19. PMID: 15523117.
    Citations: 61     Fields:    Translation:Humans
  44. Hossain T, Kappelman MD, Perez-Atayde AR, Young GJ, Huttner KM, Christou H. Primary ciliary dyskinesia as a cause of neonatal respiratory distress: implications for the neonatologist. J Perinatol. 2003 Dec; 23(8):684-7. PMID: 14647169.
    Citations: 8     Fields:    Translation:HumansCells
  45. Christou H, Serdy S, Mantzoros CS. Leptin in relation to growth and developmental processes in the fetus. Semin Reprod Med. 2002 May; 20(2):123-30. PMID: 12087497.
    Citations: 7     Fields:    Translation:HumansAnimals
  46. Minamino T, Christou H, Hsieh CM, Liu Y, Dhawan V, Abraham NG, Perrella MA, Mitsialis SA, Kourembanas S. Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8798-803. PMID: 11447290.
    Citations: 116     Fields:    Translation:HumansAnimals
  47. Christou H, Connors JM, Ziotopoulou M, Hatzidakis V, Papathanassoglou E, Ringer SA, Mantzoros CS. Cord blood leptin and insulin-like growth factor levels are independent predictors of fetal growth. J Clin Endocrinol Metab. 2001 Feb; 86(2):935-8. PMID: 11158070.
    Citations: 40     Fields:    Translation:Humans
  48. Christou H, Van Marter LJ, Wessel DL, Allred EN, Kane JW, Thompson JE, Stark AR, Kourembanas S. Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. Crit Care Med. 2000 Nov; 28(11):3722-7. PMID: 11098980.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  49. Christou H, Morita T, Hsieh CM, Koike H, Arkonac B, Perrella MA, Kourembanas S. Prevention of hypoxia-induced pulmonary hypertension by enhancement of endogenous heme oxygenase-1 in the rat. Circ Res. 2000 Jun 23; 86(12):1224-9. PMID: 10864912.
    Citations: 63     Fields:    Translation:Animals
  50. Yet SF, Perrella MA, Layne MD, Hsieh CM, Maemura K, Kobzik L, Wiesel P, Christou H, Kourembanas S, Lee ME. Hypoxia induces severe right ventricular dilatation and infarction in heme oxygenase-1 null mice. J Clin Invest. 1999 Apr; 103(8):R23-9. PMID: 10207174.
    Citations: 119     Fields:    Translation:Animals
  51. Christou H, Magnani B, Morse DS, Allred EN, Van Marter LJ, Wessel DL, Kourembanas S. Inhaled nitric oxide does not affect adenosine 5'-diphosphate-dependent platelet activation in infants with persistent pulmonary hypertension of the newborn. Pediatrics. 1998 Dec; 102(6):1390-3. PMID: 9832574.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  52. Kourembanas S, Morita T, Christou H, Liu Y, Koike H, Brodsky D, Arthur V, Mitsial SA. Hypoxic responses of vascular cells. Chest. 1998 Jul; 114(1 Suppl):25S-28S. PMID: 9676610.
    Citations: 7     Fields:    Translation:HumansAnimals
  53. Liu Y, Christou H, Morita T, Laughner E, Semenza GL, Kourembanas S. Carbon monoxide and nitric oxide suppress the hypoxic induction of vascular endothelial growth factor gene via the 5' enhancer. J Biol Chem. 1998 Jun 12; 273(24):15257-62. PMID: 9614141.
    Citations: 31     Fields:    Translation:AnimalsCells
  54. Christou H, Yoshida A, Arthur V, Morita T, Kourembanas S. Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension. Am J Respir Cell Mol Biol. 1998 Jun; 18(6):768-76. PMID: 9618381.
    Citations: 36     Fields:    Translation:Animals
  55. Christou H, Adatia I, Van Marter LJ, Kane JW, Thompson JE, Stark AR, Wessel DL, Kourembanas S. Effect of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5'-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J Pediatr. 1997 Apr; 130(4):603-11. PMID: 9108859.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  56. Kourembanas S, Morita T, Liu Y, Christou H. Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature. Kidney Int. 1997 Feb; 51(2):438-43. PMID: 9027718.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.